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https://www.readbyqxmd.com/read/29776626/insomnia-symptoms-and-their-association-with-workplace-productivity-cross-sectional-and-pre-post-intervention-analyses-from-a-large-multinational-manufacturing-company
#1
Colin A Espie, Brent Pawlecki, Dickon Waterfield, Kit Fitton, Michael Radocchia, Annemarie I Luik
BACKGROUND: Symptoms of insomnia are common and might impact work productivity. We investigated the relationship between insomnia symptoms and workplace productivity in a global manufacturing company. METHODS: Within an uncontrolled, cross-sectional study, employees from a US-based company were invited to participate in an online evaluation comprising the Sleep Condition Indicator (SCI) measuring symptoms of insomnia (high score indicating better sleep), 2 items of the Work Productivity and Impairment Index (WPAI) measuring 'presenteeism' and 'absenteeism' (high score indicating loss of work productivity) and 1 item of the Perceived Stress Scale (PSS) from January 2015 onwards...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29768112/-marvin-the-paranoid-android-the-case-of-an-alpha-pvp-user-in-the-expanding-galaxy-of-nps
#2
Simonato Pierluigi, Bulsis Laura, Negri Attilio, Bansal Gurjeet K, Pessa Gloria, Mioni Davide, Giuseppe Borgherini, Martinotti Giovanni, Schifano Fabrizio, Giulia Perini, Corazza Ornella
Alpha-PVP can be defined as a novel psychoactive substance (NPS)-more specifically, a novel synthetic cathinone with unpredictable stimulant effects in humans. "Marvin" arrived at a Dual Diagnosis Unit at Parco dei Tigli, Italy. He underwent a 30-day rehabilitation program to overcome his problematic Alpha-PVP use as a psychonaut. We conducted an online search to understand the properties of Alpha-PVP and its presence in scientific literature, reviewing official reports and the online drug market (e...
May 16, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29767825/-palliative-sedation-development-and-consensus-of-a-german-language-documentation-template
#3
C Klein, C Wittmann, K N Wendt, C Ostgathe, S Stiel
BACKGROUND: Palliative sedation (PS) serves as a therapeutic option in cases of otherwise intractable suffering. As the use of sedative and hypnotic medication in many diverse situations is a core competency of anesthesiology, anesthesiologists are confronted with questions of sedative therapy at the end of life in institutions for specialized palliative care, in intensive care units and intermediate care wards. In recent years a number of guidelines have been published internationally but so far no official guidelines exist in Germany...
May 16, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#4
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29763767/to-deliver-or-not-to-deliver-cognitive-behavioral-therapy-for-eating-disorders-replication-and-extension-of-our-understanding-of-why-therapists-fail-to-do-what-they-should-do
#5
Sandra Mulkens, Chloé de Vos, Anastacia de Graaff, Glenn Waller
OBJECTIVE: This study investigated the extent to which therapists fail to apply empirically supported treatments in a sample of clinicians in The Netherlands, delivering cognitive behavioral therapy for eating disorders (CBT-ED). It aimed to replicate previous findings, and to extend them by examining other potential intra-individual factors associated with the level of (non-)use of core CBT-ED techniques. METHOD: Participants were 139 clinicians (127 women; mean age 41...
May 4, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29761486/treatment-of-atopic-eczema-treat-registry-taskforce-an-international-delphi-exercise-to-identify-a-core-set-of-domains-and-domain-items-for-national-atopic-eczema-photo-and-systemic-therapy-registries
#6
L A A Gerbens, C J Apfelbacher, A D Irvine, S Barbarot, R J de Booij, A E Boyce, M Deleuran, L F Eichenfield, M H Hof, M A Middelkamp-Hup, A Roberts, J Schmitt, C Vestergaard, D Wall, S Weidinger, P R Williamson, C Flohr, P I Spuls
BACKGROUND: Evidence of immunomodulatory therapies to guide clinical management for atopic eczema (AE) is scarce, despite frequent and often off-label use. Patient registries provide valuable evidence for the effects of treatments under real world conditions which can inform treatment guidelines, give the opportunity for health economic evaluation and the evaluation of quality of care, as well as pharmacogenetic and -dynamic research which cannot be adequately addressed in clinical trials...
May 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29756556/mapping-the-scope-of-occupational-therapy-practice-in-palliative-care-a-european-association-for-palliative-care-cross-sectional-survey
#7
Gail Eva, Deidre Morgan
BACKGROUND: Occupational therapists play an integral role in the care of people with life-limiting illnesses. However, little is known about the scope of occupational therapy service provision in palliative care across Europe and factors influencing service delivery. AIM: This study aimed to map the scope of occupational therapy palliative care interventions across Europe and to explore occupational therapists' perceptions of opportunities and challenges when delivering and developing palliative care services...
May 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29753489/short-communication-drying-off-practices-and-use-of-dry-cow-therapy-in-finnish-dairy-herds
#8
M J Vilar, M Hovinen, H Simojoki, P J Rajala-Schultz
The objective of this study was to survey drying-off practices and use of dry cow therapy (DCT) in Finland through an online questionnaire. The questionnaire was accessible to all dairy farmers of the Finnish dairy herd recording system in 2016 (approximately 5,400 farms). In total, 715 dairy producers across the country, representative of the Finnish dairy industry, participated in the survey. Cows were dried off gradually in most of the farms. Most farms (78%) reported using selective DCT, whereas 9% of farms did not use any DCT, and 13% of farms applied blanket DCT...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29753112/patients-with-chronic-spinal-pain-benefit-from-pain-neuroscience-education-regardless-the-self-reported-signs-of-central-sensitization-secondary-analysis-of-a-randomized-controlled-multicentre-trial
#9
Anneleen Malfliet, Jeroen Kregel, Mira Meeus, Lieven Danneels, Barbara Cagnie, Nathalie Roussel, Jo Nijs
BACKGROUND: Pain neuroscience education is effective in chronic pain management. Central sensitization (i.e. generalized hypersensitivity) is often explained as underlying mechanism for chronic pain, because of its clinical relevance and influence on pain severity, prognosis, and treatment outcome. OBJECTIVES: To examine whether patients with more or fewer symptoms of central sensitization respond differently to pain neuroscience education. DESIGN: A secondary analysis of a multicentre, triple-blind randomized controlled trial SETTING: University hospital Ghent and University Hospital Brussels, Belgium...
May 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29750955/the-comparing-options-for-management-patient-centered-results-for-uterine-fibroids-compare-uf-registry-rationale-and-design
#10
Elizabeth A Stewart, Barbara L Lytle, Laine Thomas, Ganesa R Wegienka, Vanessa Jacoby, Michael P Diamond, Wanda K Nicholson, Raymond M Anchan, Sateria Venable, Kedra Wallace, Erica E Marsh, George L Maxwell, Bijan J Borah, William H Catherino, Evan R Myers
OBJECTIVE: To design and establish a uterine fibroid (UF) registry based in the United States (US) to provide comparative effectiveness data regarding UF treatment. STUDY DESIGN: We report here the design and initial recruitment for the Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) registry (Clinicaltrials.gov, NCT02260752), funded by the Agency for Healthcare Research and Quality (AHRQ) in collaboration with the-Patient-Centered Outcomes Research Institute (PCORI)...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29749482/a-panel-of-7-prognosis-related-long-non-coding-rnas-to-improve-platinum-based-chemoresistance-prediction-in-ovarian-cancer
#11
Jing Song, Wanfeng Zhang, Sen Wang, Kun Liu, Fangzhou Song, Longke Ran
In order to study the role of long non-coding RNAs (lncRNAs) in predicting platinum-based chemoresistance in patients with high-grade serous ovarian carcinoma (HGS-OvCa), a=7-lncRNA signature was developed by analyzing 561 microarrays and 136 specimens from RNA-sequencing (RNA-seq) obtained from online databases [odds ratio (OR), 2.859; P<0.0001]. The upregulated lncRNAs (RP11-126K1.6, ZBED3-AS1, RP11-439E19.10 and RP11‑348N5.7) and downregulated lncRNAs [RNF144A-AS1, growth arrest specific 5 (GAS5) and F11-AS1] exhibited high sensitivity and specificity in predicting chemoresistance in the Gene Expression Omnibus and the Cancer Genome Atlas (area under curve >0...
May 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29749287/a-qualitative-exploration-of-weight-bias-and-quality-of-health-care-among-health-care-professionals-using-hypothetical-patient-scenarios
#12
Justine Seymour, Jennifer L Barnes, Julie Schumacher, Rachel L Vollmer
The purpose of this study was to determine whether weight bias exhibited by health care professionals (HCPs) impacts quality of health care provided to individuals with obesity. HCPs (n = 220; 88% female, 87% nurses) in the Midwest region of the United States were recruited to complete an online survey. In this within-subjects study design, participants completed the Attitudes Towards Obese Persons (ATOP) scale to assess weight bias and responded to 2 (1 person with obesity and 1 person without obesity) hypothetical patient scenarios to evaluate quality of care...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29749112/technology-enhanced-writing-therapy-for-people-with-aphasia-results-of-a-quasi-randomized-waitlist-controlled-study
#13
Jane Marshall, Anna Caute, Katie Chadd, Madeline Cruice, Katie Monnelly, Stephanie Wilson, Celia Woolf
BACKGROUND: Acquired writing impairment, or dysgraphia, is common in aphasia. It affects both handwriting and typing, and may recover less well than other aphasic symptoms. Dysgraphia is an increasing priority for intervention, particularly for those wishing to participate in online written communication. Effective dysgraphia treatment studies have been reported, but many did not target, or did not achieve, improvements in functional writing. Functional outcomes might be promoted by therapies that exploit digital technologies, such as voice recognition and word prediction software...
May 10, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29749101/understanding-patient-adherence-and-concerns-with-statins-and-medication-discussions-with-physicians-action-a-survey-on-the-patient-perspective-of-dialogue-with-healthcare-providers-regarding-statin-therapy
#14
Eliot A Brinton
BACKGROUND: Statin therapy is used first-line for cholesterol lowering and prevention of atherosclerotic cardiovascular disease (CVD), but side effects and the potential for drug-drug interactions may complicate its use. Provider-patient communication is essential for shared decision-making, which, in turn, is recommended by guidelines to reduce or overcome these challenges. Unfortunately, relatively little is known about provider-patient communication surrounding statin use. METHOD: We conducted an online survey of 5,014 patients, U...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29748073/pyoderma-gangrenosum-after-breast-surgery-a-systematic-review
#15
REVIEW
Denis C Ehrl, Paul I Heidekrueger, P Niclas Broer
BACKGROUND: Post-surgical pyoderma gangrenosum (PSPG) is a rare inflammatory skin disorder of unknown aetiology. Given its similar presentation to wound infection and lack of reliable diagnostic tests as well as pathognomonic clinical features, PSPG is difficult to diagnose. The aim of this review was to identify factors contributing to PSPG to aid with timely diagnosis and appropriate therapy. METHODS: A systematic literature review was performed by following PRISMA guidelines, focusing on PSPG after reconstructive and aesthetic breast surgery...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29747787/preferred-exercise-modalities-in-patients-with-intermittent-claudication
#16
Amy Elizabeth Harwood, Louise Helen Hitchman, Lee Ingle, Patrick Doherty, Ian Clifford Chetter
Conventional supervised exercise programs (SEPs) for claudicants are traditionally based on time-constrained, group-based structured programs usually at a hospital site. Uptake of an SEP is poor, despite the high-level evidence demonstrating its clinical effectiveness; therefore, alternative forms of exercise programs are needed which are more acceptable to patients. This study aimed to explore a range of exercise modalities to determine patient preferences for exercise delivery on a national level. This was a questionnaire survey to identify and incorporate patient preferences when designing a multicenter nationwide health-service evaluation of patient preference to exercise in the United Kingdom's National Health Service (the PREFER study)...
June 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29747706/does-online-insomnia-treatment-reduce-depressive-symptoms-a-randomized-controlled-trial-in-individuals-with-both-insomnia-and-depressive-symptoms
#17
T van der Zweerde, A van Straten, M Effting, S D Kyle, J Lancee
BACKGROUND: Insomnia is effectively treated with online Cognitive Behavioral Therapy for Insomnia (CBT-I). Previous research has suggested the effects might not be limited to sleep and insomnia severity, but also apply to depressive symptoms. Results, however, are mixed. METHODS: In this randomized controlled trial we investigated the effects of guided online CBT-I on depression and insomnia in people suffering from symptoms of both. Participants (n = 104) with clinical insomnia and at least subclinical depression levels were randomized to (1) guided online CBT-I and sleep diary monitoring (i-Sleep) or (2) control group (sleep diary monitoring only)...
May 11, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29745472/advanced-practice-radiation-therapists-an-australian-context
#18
REVIEW
Bronwyn Hilder, Pieter VanDam, Kathleen Doherty
The purpose of this scoping review is to examine the literature regarding the development, implementation, scope and extent of Advanced Practice Radiation Therapist (APRT) roles in Australia in peer reviewed journals, government reports, conference proceedings and reports. A search was undertaken of PubMed, Web of Science and CINAHL, the ASMIRT website and, and Google Scholar to identify relevant documents. Combinations of keywords with Boolean operators ((advanced practice) OR (advanced practitioner) OR (specialist)) AND ((radiation therapist) OR (radiation therapy)) were used...
May 10, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29742587/exploratory-application-of-neuropharmacometabolomics-in-severe-childhood-traumatic-brain-injury
#19
Fanuel T Hagos, Philip E Empey, Pengcheng Wang, Xiaochao Ma, Samuel M Poloyac, Hülya Bayır, Patrick M Kochanek, Michael J Bell, Robert S B Clark
OBJECTIVES: To employ metabolomics-based pathway and network analyses to evaluate the cerebrospinal fluid metabolome after severe traumatic brain injury in children and the capacity of combination therapy with probenecid and N-acetylcysteine to impact glutathione-related and other pathways and networks, relative to placebo treatment. DESIGN: Analysis of cerebrospinal fluid obtained from children enrolled in an Institutional Review Board-approved, randomized, placebo-controlled trial of a combination of probenecid and N-acetylcysteine after severe traumatic brain injury (Trial Registration NCT01322009)...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29741110/vaginal-health-insights-views-attitudes-viva-latam-results-from-a-survey-in-latin-america
#20
R E Nappi, N R de Melo, M Martino, C Celis-González, P Villaseca, S Röhrich, S Palacios
OBJECTIVE: To investigate awareness in Latin America, knowledge of postmenopausal vaginal atrophy was evaluated in a sample of women from this region. METHODS: A total of 2509 postmenopausal women aged 55-65 years, resident in Argentina, Brazil, Chile, Colombia and Mexico, completed a structured online questionnaire. RESULTS: Over half the surveyed population (57%) reported experiencing symptoms of vaginal atrophy. Only 6% of the overall cohort attributed symptoms of vaginal atrophy directly to the condition, and 71% did not consider the condition to be chronic, resulting in many women not accessing effective therapy...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
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