Qian Zeng, Bin-Bin Wen, Xin Liu, Yong-Yu Luo, Zhen-Gang Hu, Lei Huang, Xiao-Hua Zhang, Xiao-Ting Huang, Ting-Ting Zhou, Xiao-Xue Sang, Yu-Yang Luo, Da-Yan Xiong, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
BACKGROUND: Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in pulmonary fibrosis is yet to be established. Hence, in this investigation, it was attempted to figure out the anti-pulmonary fibrosis influences of protodioscin and its pharmacological properties related to oxidative stress. METHODS: A mouse lung fibrosis model was generated using tracheal injections of bleomycin, followed by intraperitoneal injection of different concentrations of protodioscin, and the levels of oxidative stress and fibrosis were detected in the lungs...
April 8, 2024: Chinese Medicine