keyword
MENU ▼
Read by QxMD icon Read
search

Autophagy and laryngeal carcinoma

keyword
https://www.readbyqxmd.com/read/28761177/analysis-of-autophagy-gene-polymorphisms-in-spanish-patients-with-head-and-neck-squamous-cell-carcinoma
#1
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira Del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713931/downregulation-of-mirna-26b-inhibits-cancer-proliferation-of-laryngeal-carcinoma-through-autophagy-by-targeting-ulk2-and-inactivation-of-the-pten-akt-pathway
#2
Shujing Wang, Dandan Guo, Congying Li
Laryngeal carcinoma is one of the most common tumors of the head and neck cancers, the pathogenesis of which remains yet unclear. It has been discovered through research that microRNAs (miRNAs) play an important role during the genesis of laryngeal carcinoma. In the present study we investigated the effect of miRNA-26b on the proliferation of laryngeal carcinoma and elucidated the potential underlying mechanisms in order to provide new targets for laryngeal carcinoma. Firstly, we found that miRNA-26b expression was significantly increased in patients with laryngeal carcinoma, compared with normal volunteers...
July 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28677816/galangin-suppresses-human-laryngeal-carcinoma-via-modulation-of-caspase-3-and-akt-signaling-pathways
#3
Hai-Xu Wang, Chen Tang
Laryngeal cancers are mostly squamous cell carcinomas. Although targeting radio-resistant cancer cells is important for improving the treatmental efficiency, the signaling pathway- and therapeutic strategy-related to laryngeal carcinoma still require further study. Galangin is an active pharmacological ingredient, isolated from propolis and Alpinia officinarum Hance, and has been reported to have anticancer and anti-oxidative properties through regulation of cell cycle, resulting in angiogenesis, apoptosis, invasion and migration without triggering any toxicity in normal cells...
August 2017: Oncology Reports
https://www.readbyqxmd.com/read/28352997/deprivation-of-asparagine-triggers-cytoprotective-autophagy-in-laryngeal-squamous-cell-carcinoma
#4
Yunxiang Ji, Li Li, Qilei Tao, Xuyao Zhang, Jingyun Luan, Shuwei Zhao, Huanhai Liu, Dianwen Ju
Laryngeal squamous cell carcinoma (LSCC), one of the most common malignancies in the head and neck, has poor prognosis and high mortality. The need of novel and effective treatment for LSCC is urgent. Asparaginase, an enzyme-depriving asparagine, has been employed for the treatment of various cancers. In this study, we reported for the first time that asparaginase could induce remarkable cytotoxicity and caspase-dependent apoptosis in human LSCC Tu212 and Tu686 cells. Meanwhile, autophagy was triggered by asparaginase in LSCC cells, which was confirmed by accumulation of autophagosomes and the conversion of light chain 3-I (LC3-I) to LC3-II...
March 28, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27551764/fisetin-inhibits-laryngeal-carcinoma-through-regulation-of-akt-nf-%C3%AE%C2%BAb-mtor-and-erk1-2-signaling-pathways
#5
Xi-Jun Zhang, Shen-Shan Jia
Targeting cancer cells is crucial for improving the efficiency of laryngeal cancer treatment. However, the signaling pathway and therapeutic strategy, related to the tumor, still need further research. Dietary flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) found in many fruits and vegetables has been shown in preclinical studies to inhibit cancer growth through regulating cell cycle, apoptosis, angiogenesis, invasion and metastasis without causing any toxicity to normal cells. PI3K/AKT and ERK1/2 have been known as essential signaling pathways to modulate cell proliferation, apoptosis as well as autophagy via mTOR, Caspase-3 and NF-κB signals...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27211910/ascorbic-acid-induces-necrosis-in-human-laryngeal-squamous-cell-carcinoma-via-ros-pkc-and-calcium-signaling
#6
Min-Woo Baek, Heui-Seung Cho, Sun-Hun Kim, Won-Jae Kim, Ji-Yeon Jung
Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochrome c. Hep2 cells exposed to ascorbic acid exhibited membrane rupture and swelling, the morphological characteristics of necrotic cell death. The generation of reactive oxygen species (ROS) was increased in Hep2 cells treated with ascorbic acid, and pretreatment with N-acetylcysteine blocked ascorbic acid-induced cell death...
February 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25904129/the-role-of-autophagy-in-the-cytotoxicity-induced-by-recombinant-human-arginase-in-laryngeal-squamous-cell-carcinoma
#7
Chen Lin, Ziyu Wang, Li Li, Yong He, Jiajun Fan, Zhongyu Liu, Shuwei Zhao, Dianwen Ju
Laryngeal squamous cell carcinoma (LSCC), one of the most common malignant solid tumors in the world, has a high rate of mortality, recurrence, and metastasis. Recombinant human arginase (rhArg) recently has been developed in arginine deprivation therapy for a number of malignant tumors. In the present study, we observed that rhArg triggered significant cytotoxicity in human laryngeal squamous cell carcinoma Tu212 cells. Meanwhile, we observed that rhArg simultaneously activated autophagic flux in Tu212 cells, which was demonstrated by the accumulation of autophagosome and light chain 3 II (LC3-II)...
October 2015: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/24838151/autophagy-interplays-with-apoptosis-and-cell-cycle-regulation-in-the-growth-inhibiting-effect-of-trisenox-in-hep-2-a-laryngeal-squamous-cancer
#8
Débora Lima Pereira, Ana Carolina Dos Santos Ferreira, Giselle Pinto de Faria, Jolie Kiemlian Kwee
Laryngeal squamous cell carcinoma (LSCC) is the most common among several types of head and neck cancers. Current treatments have a poor effect on early and advanced cases, and further investigations for novel agents against LSCCs are desirable. In this study, we elucidate the cytotoxic enhancing effect of arsenic trioxide (As2O3) combined with L-buthionine sulfoximine (BSO) in LSCC. The effect of BSO with As2O3 or Cisplatin (CDDP) on cell viability was examined using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...
January 2015: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/24751611/chloroquine-synergizes-sunitinib-cytotoxicity-via-modulating-autophagic-apoptotic-and-angiogenic-machineries
#9
Amal Kamal Abdel-Aziz, Samia Shouman, Ebtehal El-Demerdash, Mohamed Elgendy, Ashraf B Abdel-Naim
Tyrosine kinases play a pivotal role in oncogenesis. Although tyrosine kinase inhibitors as sunitinib malate are used in cancer therapy, emerging studies report compromised cytotoxicity when used as monotherapy and thus combinations with other anti-cancer agents is recommended. Chloroquine is a clinically available anti-malarial agent which has been shown to exhibit anti-cancer activity. In the current study, we questioned whether chloroquine can modulate sunitinib cytotoxicity. We found that chloroquine synergistically augmented sunitinib cytotoxicity on human breast (MCF-7 and T-47D), cervical (Hela), colorectal (Caco-2 and HCT116), hepatocellular (HepG2), laryngeal (HEp-2) and prostate (PC3) cancer cell lines as indicated by combination and concentration reduction indices...
June 25, 2014: Chemico-biological Interactions
https://www.readbyqxmd.com/read/24682729/combined-treatment-with-quercetin-and-imperatorin-as-a-potent-strategy-for-killing-hela-and-hep-2-cells
#10
Dorota Bądziul, Joanna Jakubowicz-Gil, Roman Paduch, Kazimierz Głowniak, Antoni Gawron
The aim of the present study was to assess the effect of quercetin and imperatorin administered separately and in combination on apoptosis and autophagy induction in human cervical carcinoma HeLa cells and laryngeal carcinoma Hep-2 cells cultured in vitro. Conducted MTT measurements proved that quercetin and imperatorin displayed a strong antiproliferative activity manifested in markedly reduction of HeLa and Hep-2 cells viability as a result of treatment with 50 μM of each compound. Further cell staining assays revealed that concentration mentioned above generated the highest percentage of apoptotic cells especially in the case of application of both drugs for 48 h...
July 2014: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/24600487/mtor-inhibitor-azd8055-inhibits-proliferation-and-induces-apoptosis-in-laryngeal-carcinoma
#11
Lijing Zhao, Bo Teng, Lianji Wen, Qingjie Feng, Hebin Wang, Na Li, Yafang Wang, Zuowen Liang
The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth, survival, and autophagy. Allosteric inhibitors of mTORC1, such as rapamycin, have been extensively used to study tumor cell growth, proliferation, and autophagy but have shown only limited clinical utility. Here, we describe AZD8055, a novel ATP-competitive inhibitor of mTOR kinase activity, against all class I phosphatidylinositol3-kinase (PI3K) and other members of the PI3K-like kinase family...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/23686476/prognostic-significance-of-beclin-1-expression-in-laryngeal-squamous-cell-carcinoma
#12
Li Huang, Shuang Wang, Shi-Sheng Li, Xin-Ming Yang
Beclin-1 plays a critical role in the regulation of autophagy, apoptosis, differentiation and the development and progression of cancer. The aim of the present investigation was to analyze the Beclin-1 protein expression and to assess its prognostic significance in tissue of laryngeal squamous cell carcinoma (LSCC). Beclin-1 protein expression in 82 primary laryngeal squamous cell carcinoma and 40 paracarcinoma non-tumor tissue samples was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' outcome...
October 2013: Pathology Oncology Research: POR
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"