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https://www.readbyqxmd.com/read/29653129/delivering-drugs-to-the-lungs-the-history-of-repurposing-in-the-treatment-of-respiratory-diseases
#1
Stephen P Newman
The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects...
April 10, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29652518/discoidin-domain-receptor-2-signaling-regulates-fibroblast-apoptosis-through-pdk1-akt
#2
Shijing Jia, Manisha Agarwal, Jibing Yang, Jeffrey C Horowitz, Eric S White, Kevin K Kim
Progressive fibrosis is a complication of many chronic diseases and collectively, organ fibrosis is the leading cause of death in the US. Fibrosis is characterized by accumulation of activated fibroblasts and excessive deposition of extracellular matrix proteins, especially type I collagen. Extensive research has supported a role for matrix signaling in propagating fibrosis but type I collagen itself is often considered an end product of fibrosis rather than an important regulator of continued collagen deposition...
April 13, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29649237/bronchoalveolar-lavage-bal-cells-in-idiopathic-pulmonary-fibrosis-express-a-complex-pro-inflammatory-pro-repair-angiogenic-activation-pattern-likely-associated-with-macrophage-iron-accumulation
#3
Jungnam Lee, Ivan Arisi, Ermanno Puxeddu, Lazarus K Mramba, Massimo Amicosante, Carmen M Swaisgood, Marco Pallante, Mark L Brantly, C Magnus Sköld, Cesare Saltini
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause characterized by alveolar epithelial damage, patchy interstitial fibrosis and diffuse microvascular abnormalities. In IPF, alveolar clustering of iron-laden alveolar macrophages-a common sign of microhemorrhage, has been associated with vascular abnormalities and worsening of pulmonary hypertension. As iron-dependent ROS generation has been shown to induce unrestrained macrophage activation in disease models of vascular damage, we explored alveolar macrophage activation phenotype in IPF patients (n = 16) and healthy controls (CTR, n = 7) by RNA sequencing of bronchoalveolar lavage (BAL) cells...
2018: PloS One
https://www.readbyqxmd.com/read/29642520/melatonin-protects-against-lung-fibrosis-by-regulating-the-hippo-yap-pathway
#4
Xiaoguang Zhao, Jian Sun, Wei Su, Huitong Shan, Bowen Zhang, Yining Wang, Azaliia Shabanova, Hongli Shan, Haihai Liang
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not been elucidated to date. This study was designed to evaluate the anti-fibrotic role of melatonin in pulmonary fibrosis and to elucidate the potential mechanisms. We observed that melatonin markedly attenuated bleomycin (BLM)-induced experimental lung fibrosis in mice and inhibited TGF-β1-induced fibrogenesis in lung fibroblasts...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29625570/the-inhibition-of-human-lung-fibroblast-proliferation-and-differentiation-by-gs-coupled-receptors-is-not-predicted-by-the-magnitude-of-camp-response
#5
Maxine J Roberts, Rebecca E Broome, Toby C Kent, Steven J Charlton, Elizabeth M Rosethorne
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to explore alternative, novel treatment options. There is increasing evidence that the 3', 5' cyclic adenosine monophosphate (cAMP) pathway is an important modulator in the development of fibrosis, with increasing levels of cAMP able to inhibit cellular processes associated with IPF...
April 7, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29625182/idiopathic-pulmonary-fibrosis-epithelial-mesenchymal-interactions-and-emerging-therapeutic-targets
#6
REVIEW
Justin C Hewlett, Jonathan A Kropski, Timothy S Blackwell
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by progressive decline in pulmonary function and ultimately respiratory failure. Genetic and environmental risk factors have been identified that indicate injury to, and dysfunction of the lung epithelium is central to initiating the pathogenic process. Following injury to the lung epithelium, growth factors, matrikines and extracellular matrix driven signaling together activate a variety of repair pathways that lead to inflammatory cell recruitment, fibroblast proliferation and expansion of the extracellular matrix, culminating in tissue fibrosis...
April 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29621459/perverse-effects-how-insufficient-guidance-to-ipfs-can-undermine-both-research-and-health-outcomes-of-clinical-trials
#7
John W Frye
No abstract text is available yet for this article.
April 2018: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29616220/the-role-of-immune-and-inflammatory-cells-in-idiopathic-pulmonary-fibrosis
#8
REVIEW
Omkar Desai, Julia Winkler, Maksym Minasyan, Erica L Herzog
The contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly understood. While most sources agree that IPF does not result from a primary immunopathogenic mechanism, evidence gleaned from animal modeling and human studies suggests that innate and adaptive immune processes can orchestrate existing fibrotic responses. This review will synthesize the available data regarding the complex role of professional immune cells in IPF. The role of innate immune populations such as monocytes, macrophages, myeloid suppressor cells, and innate lymphoid cells will be discussed, as will the activation of these cells via pathogen-associated molecular patterns derived from invading or commensural microbes, and danger-associated molecular patterns derived from injured cells and tissues...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29616048/tnfsf14-light-exhibits-inflammatory-activities-in-lung-fibroblasts-complementary-to-il-13-and-tgf-%C3%AE
#9
Ricardo da Silva Antunes, Amit K Mehta, Lisa Madge, Joel Tocker, Michael Croft
The cytokine TNFSF14 [homologous to Lymphotoxin, exhibits Inducible expression and competes with HSV Glycoprotein D for binding to HVEM, a receptor expressed on T lymphocytes (LIGHT)] has been shown in mouse models to be important for development of lung tissue remodeling that is characteristic of asthma, idiopathic pulmonary fibrosis (IPF), and systemic sclerosis (SSc). However, its cellular targets are not fully delineated. In the present report, we show that LTβR and HVEM, the receptors for LIGHT, are constitutively expressed in primary human lung fibroblasts (HLFs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29611244/s100a12-as-a-marker-of-worse-cardiac-output-and-mortality-in-pulmonary-hypertension
#10
Argyrios Tzouvelekis, Jose D Herazo-Maya, Changwan Ryu, Jen-Hwa Chu, Yingze Zhang, Kevin F Gibson, Percy K Adonteng-Boateng, Qin Li, Hongyi Pan, Benjamin Cherry, Ferhaan Ahmad, Hubert J Ford, Erica L Herzog, Naftali Kaminski, Wassim H Fares
BACKGROUND AND OBJECTIVE: Molecular biomarkers are needed to refine prognostication and phenotyping of pulmonary hypertension (PH) patients. S100A12 is an emerging biomarker of various inflammatory diseases. This study aims to determine the prognostic value of S100A12 in PH. METHODS: Exploratory microarray analysis performed on peripheral blood mononuclear cells (PBMC) collected from idiopathic pulmonary fibrosis (IPF) patients suggested an association between S100A12 and both PH and mortality...
April 2, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29609658/sulforaphane-attenuates-pulmonary-fibrosis-by-inhibiting-the-epithelial-mesenchymal-transition
#11
Sun Young Kyung, Dae Young Kim, Jin Young Yoon, Eun Suk Son, Yu Jin Kim, Jeong Woong Park, Sung Hwan Jeong
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective treatment. The epithelial-mesenchymal transition (EMT) is a critical stage during the development of fibrosis. To assess the effect of sulforaphane (SFN) on the EMT and fibrosis using an in vitro transforming growth factor (TGF)-β1-induced model and an in vivo bleomycin (BLM)-induced model. METHODS: In vitro studies, cell viability, and cytotoxicity were measured using a Cell Counting Kit-8...
April 2, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29608882/diagnostic-ability-of-a-dynamic-multidisciplinary-discussion-in-interstitial-lung-diseases-a-retrospective-observational-study-of-938-cases
#12
Laurens J De Sadeleer, Caressa Meert, Jonas Yserbyt, Hans Slabbynck, Johny A Verschakelen, Eric K Verbeken, Birgit Weynand, Ellen De Langhe, Jan L Lenaerts, Benoit Nemery, Dirk Van Raemdonck, Geert M Verleden, Athol U Wells, Wim A Wuyts
BACKGROUND: The advice of a dynamic multidisciplinary discussion (MDD) is believed to be important in the diagnosis of interstitial lung diseases (ILD). However, to what extent MDD diagnoses differ from the preliminary diagnoses before formal work-up and MDD (preMDD diagnoses), is still insufficiently studied. METHODS: We compared preMDD and MDD diagnoses in patients discussed at the Leuven University Hospitals MDD between January 2005 and December 2015. RESULTS: Of 938 consecutive patients discussed in MDD, 755 (80...
March 30, 2018: Chest
https://www.readbyqxmd.com/read/29607163/clinico-radiological-features-and-efficacy-of-anti-fibrotic-agents-in-atypical-idiopathic-pulmonary-fibrosis
#13
Keishi Sugino, Hiroshige Shimizu, Yasuhiko Nakamura, Takuma Isshiki, Keiko Matsumoto, Sakae Homma
Background: Atypical idiopathic pulmonary fibrosis (IPF) including multiple cysts or markedly atelectatic induration in upper lung predominance occasionally can confirm the diagnosis of IPF through a multidisciplinary discussion (MDD) between clinician, radiologist and, pathologist in clinical practice. The aim of this study was to clarify the differences in clinico-radiological characteristics and the efficacy of anti-fibrotic agents between atypical IPF and typical IPF. Methods: We retrospectively evaluated the differences in clinico-radiological characteristics between patients with atypical IPF (n=44) and those with typical IPF (n=87) and examined efficacy of anti-fibrotic agents in atypical IPF...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606857/the-reliability-of-lung-ultrasound-in-assessment-of-idiopathic-pulmonary-fibrosis
#14
REVIEW
Diana Manolescu, Lavinia Davidescu, Daniel Traila, Cristian Oancea, Voicu Tudorache
Idiopathic pulmonary fibrosis (IPF) is the severest form of idiopathic interstitial pneumonia, with a median survival time estimated at 2-5 years from the time of diagnosis. It occurs mainly in elderly adults, suggesting a strong link between the fibrosis process and aging. Although chest high-resolution computed tomography (HRCT) is currently the method of choice in IPF assessment, diagnostic imaging with typical usual interstitial pneumonia (UIP) provides definitive results in only 55%, requiring an invasive surgical procedure such as lung biopsy or cryobiopsy for the final diagnostic analysis...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29605201/distinctive-characteristics-and-prognostic-significance-of-interstitial-pneumonia-with-autoimmune-features-in-patients-with-chronic-fibrosing-interstitial-pneumonia
#15
Katsuhiro Yoshimura, Masato Kono, Yasunori Enomoto, Koji Nishimoto, Yoshiyuki Oyama, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hiromitsu Sumikawa, Takeshi Johkoh, Thomas V Colby, Haruhiko Sugimura, Takafumi Suda
BACKGROUND: Interstitial lung diseases are heterogeneous, and patients with chronic fibrosing interstitial pneumonia (CFIP) often have clinical, serologic, and morphologic features suggestive but not diagnostic of connective tissue disease. Recently, the concept of interstitial pneumonia with autoimmune features (IPAF) has been proposed as a platform for such patients. However, the prognostic role of IPAF, including the cumulative incidence of acute exacerbations (AEs), is not fully clear...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29604596/submicron-emulsion-of-cinnamaldehyde-ameliorates-bleomycin-induced-idiopathic-pulmonary-fibrosis-via-inhibition-of-inflammation-oxidative-stress-and-epithelial-mesenchymal-transition
#16
Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-Yan He, Di Zhang, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao, Si-Wang Wang
AIMS: Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. The pathogenesis is associated with inflammation and oxidative stress and epithelial-mesenchymal transition (EMT). Cinnamaldehyde exhibits antiinflammatory and antioxidant properties, but its effect on IPF is unknown. The present study is to investigate the anti-fibrotic effect and action mechanism of cinnamaldehyde on IPF. MATERIALS AND METHODS: IPF was induced by intratracheal bleomycin in mice...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29601568/-hypersensitivity-pneumonitis-and-idiopathic-pulmonary-fibrosis-case-report
#17
Barbara Mackiewicz, Jan Siwiec, Elżbieta Czekajska-Chehab, Janusz Milanowski
Hypersensitivity pneumonitis (HP), called extrinsic allergic alveolitis, is a syndrome characterized by diffuse inflammation of lung parenchyma and airways in response to the inhalation of antigens to witch the patient has been previously sensitized. The clinical presentation of HP have been categorized as acute, subacute and chronic. The patient with chronic HP may lack a history of acute episodes and usually reports the insidious onset of cough, dyspnoea, fatigue, and weight los. Idiopathic pulmonary fibrosis (IPF) is a type of lung disease that results in scarring (fibrosis) of the lungs for an unknown reason...
March 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29598007/aav6-mediated-il-10-expression-in-the-lung-ameliorates-bleomycin-induced-pulmonary-fibrosis-in-mice
#18
Fumio Kurosaki, Ryosuke Uchibori, Yoshihide Sehara, Yasushi Saga, Masashi Urabe, Hiroaki Mizukami, Koichi Hagiwara, Akihiro Kume
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder with limited therapeutic options. An aberrant wound healing process in response to repetitive lung injury has been suggested for its pathogenesis, and a number of cytokines including transforming growth factor (TGF)-β1 play pivotal roles in the induction and progression of fibrosis. Thus, the regulation of these pro-inflammatory conditions may reduce the progression of IPF and ameliorate its symptoms in patients. Interleukin-10 (IL-10), a pleiotropic cytokine, exerts anti-inflammatory and anti-fibrotic effects in numerous biological settings...
March 29, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29590152/clinical-spectrum-and-prognostic-factors-of-possible-uip-pattern-on-high-resolution-ct-in-patients-who-underwent-surgical-lung-biopsy
#19
Yasuhiro Kondoh, Hiroyuki Taniguchi, Kensuke Kataoka, Taiki Furukawa, Ayumi Shintani, Tomoyuki Fujisawa, Takafumi Suda, Machiko Arita, Tomohisa Baba, Kazuya Ichikado, Yoshikazu Inoue, Kazuma Kishi, Tomoo Kishaba, Osamu Nishiyama, Takashi Ogura, Keisuke Tomii, Sakae Homma
BACKGROUND: Few studies have reported the diagnostic variability in patients with a possible usual interstitial pneumonia (UIP) pattern on high-resolution CT (HRCT) who underwent surgical lung biopsy (SLB), and the prognostic factors for these patients have not been fully evaluated. We retrospectively investigated the frequency of idiopathic pulmonary fibrosis (IPF) and prognostic factors in patients with possible UIP pattern on HRCT. METHODS: Consecutive patients who had a possible UIP pattern on HRCT, underwent SLB, and had a diagnosis of IIPs before SLB were retrospectively recruited from 10 hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29587761/evaluation-of-oxidative-stress-biomarkers-in-idiopathic-pulmonary-fibrosis-and-therapeutic-applications-a-systematic-review
#20
REVIEW
Alessandro G Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF. METHODS: We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017...
March 27, 2018: Respiratory Research
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