Sarah McCallum, Keshav B Suresh, Timothy Islam, Ann W Saustad, Oksana Shelest, Aditya Patil, David Lee, Brandon Kwon, Inga Yenokian, Riki Kawaguchi, Connor H Beveridge, Palak Manchandra, Caitlin E Randolph, Gordon P Meares, Ranjan Dutta, Jasmine Plummer, Simon R V Knott, Gaurav Chopra, Joshua E Burda
Spared regions of the damaged central nervous system undergo dynamic remodeling and exhibit a remarkable potential for therapeutic exploitation. Here, lesion-remote astrocytes (LRAs), which interact with viable neurons, glia and neural circuitry, undergo reactive transformations whose molecular and functional properties are poorly understood. Using multiple transcriptional profiling methods, we interrogated LRAs from spared regions of mouse spinal cord following traumatic spinal cord injury (SCI). We show that LRAs acquire a spectrum of molecularly distinct, neuroanatomically restricted reactivity states that evolve after SCI...
March 17, 2024: bioRxiv