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https://www.readbyqxmd.com/read/29786940/glycoinformatics-bridging-isolated-islands-in-the-sea-of-data
#1
Ksenia S Egorova, Philip V Toukach
Glycoinformatics is a young scientific branch, which assists the scientific community in carbohydrate research. In spite of fundamental roles of glycans in living organisms, the informatization of the field is significantly hindered by the lack of standards, data indices, protocols and tools widely recognized by researchers and publishers. The connection of the existing glycoinformatics projects with each other and with global life-science projects is far from complete. Moreover, in contrast to genes and proteins, there is no obligatory unique identifier for each natural carbohydrate structure...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29786871/gender-specific-effects-of-selection-for-drinking-in-the-dark-on-the-network-roles-of-coding-and-non-coding-rnas
#2
Ovidiu Dan Iancu, Alex Colville, Beth Wilmot, Robert Searles, Priscila Darakjian, Christina Zheng, Shannon McWeeney, Sunita Kawane, John C Crabbe, Pamela Metten, Denesa Oberbeck, Robert Hitzemann
BACKGROUND: Transcriptional differences between Heterogeneous stock (HS/NPT) mice and High Drinking in the Dark (HDID) selected mouse lines have previously been described based on microarray technology coupled with network based analysis (Iancu et al., 2013b). The network changes were reproducible in two independent selections and largely confined to two distinct network modules; in contrast differential expression appeared more specific to each selected line. The current study extends these results by utilizing RNA-Seq technology, allowing evaluation of the relationship between genetic risk and transcription of non-coding RNA; we additionally evaluate sex-specific transcriptional effects of selection...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786854/muffins-elaborated-with-optimized-monoglycerides-oleogels-from-solid-fat-replacer-obtention-to-product-quality-evaluation
#3
Anabella S Giacomozzi, María E Carrín, Camila A Palla
This study demonstrates the effectiveness of using oleogels from high oleic sunflower oil (HOSO) and monoglycerides as solid fat replacers in a sweet bakery product. Firstly, a methodology to obtain oleogels with desired properties based on mathematical models able to describe relationships between process and product characteristics variables followed by multi-objective optimization was applied. Later, muffins were prepared with the optimized oleogels and their physicochemical and textural properties were compared with those of muffins formulated using a commercial margarine (Control) or only HOSO...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786781/the-ejes-3d-tool-for-personalized-prescription-of-exercise-in-axial-spondyloarthritis-through-multimedia-animations-pilot-study
#4
Mariano Tomás Flórez, Raquel Almodóvar, Fernando García Pérez, Ana Belén Rodríguez Cambrón, Loreto Carmona, María Ángeles Pérez Manzanero, Juan Aboitiz Cantalapiedra, Ana Urruticoechea-Arana, Carlos J Rodríguez Lozano, Carmen Castro, Cristina Fernández-Carballido, Eugenio de Miguel, Eva Galíndez, José Luis Álvarez Vega, Juan Carlos Torre Alonso, Luis F Linares, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Pedro Zarco
To develop and evaluate a web application based on multimedia animations, combined with a training program, to improve the prescription of exercises in spondyloarthritis (SpA). After a review of exercises included in the main clinical trials and recommendations of international societies, a multidisciplinary team-rehabilitators, rheumatologists, physiotherapists, computer scientists and graphic designers-developed a web application for the prescription of exercises (EJES-3D). Once completed, this was presented to 12 pairs of rehabilitators-rheumatologists from the same hospital in a workshop...
May 21, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29786749/long-noncoding-rna-myocardial-infarction%C3%A2-associated-transcript-is-associated-with-the-microrna%C3%A2-150%C3%A2-5p-p300-pathway-in-cardiac-hypertrophy
#5
Zhao Li, Yamin Liu, Xiaofan Guo, Guozhe Sun, Qun Ma, Ying Dai, Guangshuo Zhu, Yingxian Sun
In numerous diseases, abnormal expression of myocardial infarction‑associated transcript (MIAT) has been reported to be involved in cell proliferation, apoptosis and migration. However, whether this long non‑coding RNA MIAT has a regulatory effect on heart hypertrophy requires further investigation. To this end, the present study evaluated MIAT in hypertrophic cardiomyocytes in vitro and in vivo. Neonatal rat ventricular myocytes (NRVMs) were induced by isoproterenol (ISO) to create a cell hypertrophy model, and mice were intraperitoneally injected with ISO to establish an animal model...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29786739/synthesis-of-pure-silica-mfi-zeolites-using-imidazolium-based-long-dications-a-comparative-study-of-structure-directing-effects-derived-from-a-further-spacer-length-increase
#6
Peng Lu, Luis Gómez-Hortigüela, Miguel A Camblor
Length-dependent structure direction of linear methylimidazolium-based dications towards MFI zeolite, previously known only for the tetramethylene spacer, has also been found for octamethylene and decamethylene spacers. This works only under highly concentrated conditions, whereas dilution always tends to favor TON, a default structure that is the only zeolite obtained with the other reported dications (with tri-, penta-, and hexamethylene spacers). The locations and conformations of the dications have been studied by molecular mechanics simulations...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29786475/connecting-structure-property-and-structure-function-relationships-across-the-disciplines-of-chemistry-and-biology-exploring-student-perceptions
#7
Kathryn P Kohn, Sonia M Underwood, Melanie M Cooper
While many university students take science courses in multiple disciplines, little is known about how they perceive common concepts from different disciplinary perspectives. Structure-property and structure-function relationships have long been considered important explanatory concepts in the disciplines of chemistry and biology, respectively. Fourteen university students concurrently enrolled in introductory chemistry and biology courses were interviewed to explore their perceptions regarding 1) the meaning of structure, properties, and function; 2) the presentation of these concepts in their courses; and 3) how these concepts might be related...
June 2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29786434/ion-imaging-of-mgi-photofragment-in-ultraviolet-photodissociation-of-mass-selected-mg-ich-3-complex
#8
Kenichi Okutsu, Kenichiro Yamazaki, Motoyoshi Nakano, Keijiro Ohshimo, Fuminori Misaizu
We have observed images of MgI+ fragment ions produced in ultraviolet laser photodissociation of mass-selected Mg+ ICH3 ions at 266 nm. Split distribution almost perpendicular to the polarization direction of the photolysis laser was observed in the photofragment image. Potential energy curves of Mg+ ICH3 were obtained by theoretical calculations. Among these curves, the excited complex ion dissociated along almost repulsive potentials with several avoided crossings which was connected to MgI+ + CH3 . In the ground state of Mg+ ICH3 , the CH3 I was bonded with Mg from the iodine side, and the Mg-I-C bond angle was calculated to be 101...
May 22, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29786416/zinc-oxide-enhanced-piezoelectret-polypropylene-microfiber-for-mechanical-energy-harvesting
#9
Jianxiong Zhu, Yali Zhu, Weixing Song, Hui Wang, Min Gao, Minkyu Cho, Inkyu Park
This paper reports zinc oxide (ZnO) coated piezoelectret polypropylene (PP) microfibers with a structure of two opposite arc-shaped braces for enhanced mechanical energy harvesting. The ZnO film was coated onto PP microfibers via magnetron sputtering to form a ZnO/PP compound structure. Triboelectric Nanogenerator (TENG) based on ZnO/PP microfiber compound film was carefully designed with two opposite arc-shaped braces. The results of this study demonstrated that the mechanical energy collection efficiency of TENG based on piezoelectret PP microfiber was greatly enhanced by the coated ZnO and high voltage corona charging method...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786098/syntheses-structures-and-magnetic-properties-of-three-new-mn-ii-mo-iii-cn-7-4-molecular-magnets
#10
Xiao-Qin Wei, Qian Pi, Fu-Xing Shen, Dong Shao, Hai-Yan Wei, Xin-Yi Wang
By reaction of K4[MoIII(CN)7]·2H2O, Mn(ClO4)2·6H2O and bidentate chelating ligands, three new cyano-bridged compounds, namely Mn2(3-pypz)(H2O)(CH3CN)[Mo(CN)7] (1), Mn2(1-pypz)(H2O)(CH3CN)[Mo(CN)7] (2) and Mn2(pyim)(H2O)(CH3CN)[Mo(CN)7] (3) (3-pypz = 2-(1H-pyrazol-3-yl)pyridine, 1-pypz = 2-(1H-pyrazol-1-yl)pyridine, pyim = 2-(1H-imidazol-2-yl)pyridine), have been synthesized and characterized structurally and magnetically. Single crystal X-ray analyses revealed that although the chelating ligands are different, compounds 1 to 3 are isomorphous and crystallize in the same monoclinic space group C2/m...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29785918/proteomic-analysis-of-the-effects-of-lutein-on-mammary-gland-metabolism-in-dairy-cows
#11
Caihong Wang, Chong Wang, Jianxin Liu, Hongyun Liu
The aim of the research reported in this Research Communication was to identify differentially expressed proteins in dairy cows with normal and lutein diet and to elucidate the mechanisms of lutein-induced effects on bovine mammary gland metabolism using a comparative proteomic approach. Thirty-three differentially expressed proteins were identified from mammary gland of control diet-fed and lutein diet-fed dairy cows. Among these proteins, 15 were upregulated and 18 were downregulated in the lutein group. Functional analysis of the differentially expressed proteins showed that increased blood flow, depressed glycolysis, enhanced lactose anabolism, decreased fatty acid oxidation and up-regulated beta lactoglobulin expression were connected with lutein addition...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785892/the-monogenean-paradiplozoon-ichthyoxanthon-behaves-like-a-micropredator-on-two-of-its-hosts-as-indicated-by-stable-isotopes
#12
B Sures, M Nachev, B M Gilbert, Q M Dos Santos, M A Jochmann, D Köster, T C Schmidt, A Avenant-Oldewage
The analysis of stable isotopes of carbon and nitrogen has been used as a fingerprint for understanding the trophic interactions of organisms. Most of these studies have been applied to free-living organisms, while parasites have largely been neglected. Studies dealing with parasites so far have assessed the carbon and nitrogen signatures in endoparasites or ectoparasites of different hosts, without showing general trends concerning the nutritional relationships within host-parasite associations. Moreover, in most cases such systems involved a single host and parasite species...
May 22, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29785879/blood-and-hair-mercury-concentrations-among-cree-first-nations-of-eeyou-istchee-quebec-canada-time-trends-prenatal-exposure-and-links-to-local-fish-consumption
#13
Susannah Ripley, Elizabeth Robinson, Louise Johnson-Down, Anne Andermann, Pierre Ayotte, Michel Lucas, Evert Nieboer
To describe exposure to methylmercury among Cree, focusing on women of childbearing age, we used data from 2 studies. Multiple regression was employed to examine associations between blood and hair mercury concentrations and consumption of locally harvested fish. Approximately 9.9% of non-pregnant women aged 15-44 y and 3.9% of pregnant women required follow-up according to Health Canada's blood mercury guidance value of 40 nmol/L. 8% of hair mercury observations in the non-pregnant women and 2.5% among pregnant women exceeded the equivalent threshold of 10 nmol/g...
December 2018: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29785857/a-simulation-study-on-two-analytical-techniques-for-alternating-treatments-designs
#14
Rumen Manolov
Alternating treatments designs (ATDs) are single-case experimental designs entailing the rapid alternation of conditions, and the specific sequence of conditions is usually determined at random. The visual analysis of ATD data entails comparing the data paths formed by connecting the measurements from the same condition. Apart from visual analyses, there are at least two quantitative analytical options also comparing data paths. On option is a visual structured criterion (VSC) regarding the number of comparisons for which one conditions has to be superior to the other to consider that the difference is not only due to random fluctuations...
May 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29785841/effects-of-antipsychotic-drugs-on-neurites-relevant-to-schizophrenia-treatment
#15
REVIEW
Xu-Feng Huang, Xueqin Song
Although antipsychotic drugs are mainly used for treating schizophrenia, they are widely used for treating various psychiatric diseases in adults, the elderly, adolescents and even children. Today, about 1.2% of the worldwide population suffers from psychosis and related disorders, which translates to about 7.5 million subjects potentially targeted by antipsychotic drugs. Neurites project from the cell body of neurons and connect neurons to each other to form neural networks. Deficits in neurite outgrowth and integrity are implicated in psychiatric diseases including schizophrenia...
May 22, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29785835/predicting-the-ecological-impacts-of-large-dam-removals-on-a-river-network-based-on-habitat-network-structure-and-flow-regimes
#16
Nobuo Ishiyama, Masahiro Ryo, Taiga Kataoka, Shigeya Nagayama, Masanao Sueyoshi, Akira Terui, Terutaka Mori, Takumi Akasaka, Futoshi Nakamura
Large dams have provided vital protection and services to human life and the economy. However, an increasing number of large dams worldwide have aged considerably and have thus become hazardous due to impaired functions. The removal of large dams has excellent potential to restore habitat connectivity and flow regimes; therefore, projecting the related ecological consequences is a key emerging need for water resource and ecosystem management. However, no modeling methods are currently available for such projections at the basin scale...
May 22, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29785783/silica-gelatin-hybrid-sol-gel-coatings-a-proteomic-study-with-biocompatibility-implications
#17
N Araújo-Gomes, F Romero-Gavilán, I Lara-Sáez, F Elortza, M Azkargorta, I Iloro, M Martínez-Ibañez, J J Martín de Llano, M Gurruchaga, I Goñi, J Suay, A M Sánchez-Pérez
Osseointegration, including the foreign body reaction to biomaterials, is an immune-modulated, multifactorial, and complex healing process in which various cells and mediators are involved. The buildup of the osseointegration process is immunological and inflammation-driven, often triggered by the adsorption of proteins on the surfaces of the biomaterials and complement activation. New strategies for improving osseointegration use coatings as vehicles for osteogenic biomolecules delivery from implants. Natural polymers, such as gelatin, can mimic collagen I and enhance the biocompatibility of a material...
May 21, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29785736/new-connections-between-circadian-rhythms-photosynthesis-and-environmental-adaptation
#18
Dora L Cano-Ramirez, Antony N Dodd
No abstract text is available yet for this article.
May 21, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29785723/decreased-e-cadherin-in-mcf7-human-breast-cancer-cells-forming-multicellular-spheroids-exposed-to-simulated-microgravity
#19
Jayashree Sahana, Mohamed Zakaria Nassef, Markus Wehland, Sascha Kopp, Marcus Krüger, Thomas J Corydon, Manfred Infanger, Johann Bauer, Daniela Grimm
MCF7 human breast cancer cells were cultured under normal gravity (1g) and on a random positioning machine (RPM) preventing sedimentation. After two weeks, adherent 1g-control and adherent RPM cells (AD) as well as multicellular spheroids (MCS) were harvested. AD and MCS had been exposed to the RPM in the same culture flask. In a subsequent proteome analysis, the majority of the proteins detected showed similar label-free quantification scores (LFQ) in each of the respective subpopulations, but in both AD or MCS cultures, proteins were also found whose LFQs deviated at least twofold from their counterparts in the 1g-control cells...
May 21, 2018: Proteomics
https://www.readbyqxmd.com/read/29785676/asymmetry-of-the-greater-cornua-of-the-hyoid-bone-and-the-superior-thyroid-cornua-a-case-report
#20
Miroslav Radunovic, Batric Vukcevic, Nemanja Radojevic
The hyoid bone consists of a body and two pairs of processes: the greater cornua (GC) and the lesser cornua. The GC is connected to the superior thyroid cornu (STC) by the lateral thyrohyoid ligament. The GC and the STC share a common embryological origin from the third pharyngeal arch. During anatomical dissection of a male cadaver of 56 years of age, a combined variation of the GC and the STC was found. The left GC was 27.7 mm long, and the right GC was 30 mm long. The left GC axis was in the same plane as the hyoid body, while an angle of 33° was between the right GC axis and the hyoid body plane...
May 21, 2018: Surgical and Radiologic Anatomy: SRA
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