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https://www.readbyqxmd.com/read/29165953/an-alternative-view-of-living-well-survival-trajectory-of-korean-patients-with-kidney-failure-on-hemodialysis
#1
Jinhyang Yang
Patients with kidney failure undergoing hemodialysis rely on a hemodialysis machine for survival. Experiences of patients going through this situation were described using a phenomenological approach. These patients experienced early and late transitions within a dual structure of despair and hope, dependence and independence, and activity and passivity. Early transitions included experiencing shock and a struggle for survival. Late transitions included facing up to the reality and maintaining a hemodialysis-life balance...
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165701/the-mechano-chemistry-of-a-monomeric-reverse-transcriptase
#2
Omri Malik, Hadeel Khamis, Sergei Rudnizky, Ariel Kaplan
Retroviral reverse transcriptase catalyses the synthesis of an integration-competent dsDNA molecule, using as a substrate the viral RNA. Using optical tweezers, we follow the Murine Leukemia Virus reverse transcriptase as it performs strand-displacement polymerization on a template under mechanical force. Our results indicate that reverse transcriptase functions as a Brownian ratchet, with dNTP binding as the rectifying reaction of the ratchet. We also found that reverse transcriptase is a relatively passive enzyme, able to polymerize on structured templates by exploiting their thermal breathing...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165619/comparison-of-response-of-passive-dosimetry-systems-in-scanning-proton-radiotherapy-a-study-using-paediatric-anthropomorphic-phantoms
#3
Ž Kneževic, I Ambrozova, C Domingo, M De Saint-Hubert, M Majer, I Martínez-Rovira, S Miljanic, N Mojzeszek, P Porwol, O Ploc, M Romero-Expósito, L Stolarczyk, S Trinkl, R M Harrison, P Olko
Proton beam therapy has advantages in comparison to conventional photon radiotherapy due to the physical properties of proton beams (e.g. sharp distal fall off, adjustable range and modulation). In proton therapy, there is the possibility of sparing healthy tissue close to the target volume. This is especially important when tumours are located next to critical organs and while treating cancer in paediatric patients. On the other hand, the interactions of protons with matter result in the production of secondary radiation, mostly neutrons and gamma radiation, which deposit their energy at a distance from the target...
November 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29165370/vitamin-e-bioavailability-mechanisms-of-intestinal-absorption-in-the-spotlight
#4
REVIEW
Emmanuelle Reboul
Vitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods. It is thus of major interest to gain deeper insight into the mechanisms of vitamin E absorption, which remain only partly understood. It was long assumed that vitamin E was absorbed by passive diffusion, but recent data has shown that this process is actually far more complex than previously thought...
November 22, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165045/determination-of-the-centre-of-resistance-during-en-masse-retraction-combined-with-corticotomy-finite-element-analysis
#5
Tanes Ouejiaraphant, Bancha Samruajbenjakun, Ekachai Chaichanasiri
OBJECTIVE: To determine the effect of corticotomy on the change in the centre of resistance of the six maxillary anterior teeth Materials and methods: Three-dimensional finite element models of the maxillary anterior teeth with and without corticotomy were constructed. Brackets (size 0.022 inch × 0.028 inch) were placed passively on all anterior teeth that were set at the centre of the labial surface in the mesio-distal dimension and 3 mm from the incisal edge to the bracket slot in the vertical direction...
November 22, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/29165022/the-behavioral-health-role-in-nursing-facility-social-work
#6
Dennis R Myers, Robin K Rogers, Harold H LeCrone, Katherine Kelley
Types of compromised resident behaviors licensed nursing facility social workers encounter, the behavioral health role they enact, and effective practices they apply have not been the subject of systematic investigation. Analyses of 20 in-depth interviews with Bachelor of Social Work (BSW)/Master of Social Work (MSW) social workers averaging 8.8 years of experience identified frequently occurring resident behaviors: physical and verbal aggression/disruption, passive disruption, socially and sexually inappropriateness...
September 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164855/surface-passivation-and-supersaturation-strategies-for-regioselective-deposition-in-seeded-syntheses
#7
Alexander N Chen, Mattea M Scanlan, Sara E Skrabalak
Crystal growth theory predicts that heterogeneous nucleation will occur preferentially at defect sites, such as the vertices rather than the faces of shape-controlled seeds. Platonic metal solids are generally assumed to have vertices with nearly identical chemical potentials, and also nearly identical faces, leading to the useful generality that heterogeneous nucleation preserves the symmetry of the original seeds in the final product. Herein, we test the limits of this generality in the extreme of low supersaturation, in an effort to expand the methods available for inducing anisotropic overgrowth...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29164814/a-thrombin-receptor-derived-imaging-agent-detects-subclinical-arthritis-in-mice
#8
Beth Friedman, Michael A Whitney, Elamprakash N Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V Hingorani, Jessica Crisp, Stephen R Adams, Michael Kenner, Csilla N Lippert, Quyen T Nguyen, Monica Guma, Roger Y Tsien, Maripat Corr
OBJECTIVE: Functional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long-term outcomes. Motivated by the intersection of inflammation with coagulation protease activation, we examine coagulation protease activities in arthritic mice with a dual fluorescent Ratiometric thrombin-Activatable Cell Penetrating Peptide (RACPPNleTPRSFL ). METHOD: Mice with chronic transgenic K/BxN arthritis, or with arthritis on Day 1 of passive serum transfer induced arthritis (STIA), were imaged in vivo for Cy5 em: Cy7 em ratiometric fluorescence from proteolytic cleavage and activation of RACPPNleTPRSFL ...
November 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29164593/immune-correlates-of-clinical-outcome-in-melanoma
#9
REVIEW
Graham Pawelec
Melanoma has long been recognized as a potentially immunogenic tumour, but only recently has it become clear that the reason for this resides in its many UV-induced mutations and expression of multiple autoantigens which can be targeted by the immune system. The first successful applications of immune-based treatments included passive immunotherapy using high-dose IL-2 and/or adoptive transfer of NK-cells, as well as active immunotherapy using whole cell-derived or peptide vaccines. In the intervening decades, it has become clear that these approaches can lead to durable responses in stage III/IV melanoma, and even to functional cures - but only in a vanishingly small fraction of patients...
November 21, 2017: Immunology
https://www.readbyqxmd.com/read/29164566/drug-related-oral-malodour-halitosis-a-literature-review
#10
M Torsten, G Gómez-Moreno, A Aguilar-Salvatierra
Dry mouth (xerostomia), is a fairly common, well-researched condition, which is an indirect cause of oral malodour. This systematic literature review looked into another cause of bad breath: adverse drug reactions in the orofacial region causing halitosis. The study focused on extraoral halitosis, and its subdivisions, particularly blood borne halitosis in which malodourous compounds in the blood stream are carried to the lungs, passively diffused across the pulmonary alveolar membrane to enter the breath. An electronic search was conducted in various databases...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164541/-the-application-of-information-and-communication-technology-ict-in-nursing-education
#11
Shwu-Fen Chiou, Hsiu-Chuan Su, Ean-Wen Huang
With the rapid development of information and communication technologies (ICT) in the 21st century, all walks of life have experienced disruptive changes, including the healthcare profession. Although nurses represent the largest number of professionals in medical institutions, it is doubtful whether nurses possess sufficient capabilities to face challenges in this era of rapid medical informatization. Currently, the courses necessary to cultivate information literacy in nursing students are insufficient in Taiwan, and traditional instruction methods are largely adopted as nursing teaching strategies...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164430/eclalbasaponin-ii-ameliorates-the-cognitive-impairment-induced-by-cholinergic-blockade-in-mice
#12
Won Yong Jung, Haneul Kim, Se Jin Jeon, Hye Jin Park, Hyuck Jai Choi, Nam Jae Kim, Dong Hyun Kim, Dae Sik Jang, Jong Hoon Ryu
Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using the passive avoidance, Y-maze, and Morris water maze tasks. Eclalbasaponin II (10 or 20 mg/kg, p.o.) significantly ameliorated the cognitive dysfunction induced by scopolamine in the passive avoidance, Y-maze, and the Morris water maze tasks...
November 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29164362/coping-and-sexual-harassment-how-victims-cope-across-multiple-settings
#13
Jennifer A Scarduzio, Sarah E Sheff, Mathew Smith
The ways sexual harassment occurs both online and in face-to-face settings has become more complicated. Sexual harassment that occurs in cyberspace or online sexual harassment adds complexity to the experiences of victims, current research understandings, and the legal dimensions of this phenomenon. Social networking sites (SNS) are a type of social media that offer unique opportunities to users and sometimes the communication that occurs on SNS can cross the line from flirtation into online sexual harassment...
November 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29164092/the-nuisance-mosquito-anopheles-plumbeus-stephens-1828-in-germany-a-questionnaire-survey-may-help-support-surveillance-and-control
#14
Eva C Heym, Jette Schröder, Helge Kampen, Doreen Walther
The mosquito species Anopheles plumbeus is an aggressive biter and a potential vector of malaria parasites and West Nile virus. It occurs naturally at low population densities, as its larval development is adapted to the specific water qualities found in tree holes. However, probably owing to environmental changes, it has recently been observed in several European countries to use increasingly often artificial breeding habitats that may lead to mass development and severe annoyance to humans living close by...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29164054/effective-drug-delivery-in-diffuse-intrinsic-pontine-glioma-a-theoretical-model-to-identify-potential-candidates
#15
Fatma E El-Khouly, Dannis G van Vuurden, Thom Stroink, Esther Hulleman, Gertjan J L Kaspers, N Harry Hendrikse, Sophie E M Veldhuijzen van Zanten
Despite decades of clinical trials for diffuse intrinsic pontine glioma (DIPG), patient survival does not exceed 10% at two years post-diagnosis. Lack of benefit from systemic chemotherapy may be attributed to an intact bloodbrain barrier (BBB). We aim to develop a theoretical model including relevant physicochemical properties in order to review whether applied chemotherapeutics are suitable for passive diffusion through an intact BBB or whether local administration via convection-enhanced delivery (CED) may increase their therapeutic potential...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29163629/high-throughput-field-phenotyping-of-leaves-leaf-sheaths-culms-and-ears-of-spring-barley-cultivars-at-anthesis-and-dough-ripeness
#16
Gero Barmeier, Urs Schmidhalter
To optimize plant architecture (e.g., photosynthetic active leaf area, leaf-stem ratio), plant physiologists and plant breeders rely on destructively and tediously harvested biomass samples. A fast and non-destructive method for obtaining information about different plant organs could be vehicle-based spectral proximal sensing. In this 3-year study, the mobile phenotyping platform PhenoTrac 4 was used to compare the measurements from active and passive spectral proximal sensors of leaves, leaf sheaths, culms and ears of 34 spring barley cultivars at anthesis and dough ripeness...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163298/the-effects-of-cognitive-reappraisal-and-expressive-suppression-on-memory-of-emotional-pictures
#17
Yan Mei Wang, Jie Chen, Ben Yue Han
In the field of emotion research, the influence of emotion regulation strategies on memory with emotional materials has been widely discussed in recent years. However, existing studies have focused exclusively on regulating negative emotion but not positive emotion. Therefore, in the present study, we investigated the influence of emotion regulation strategies for positive emotion on memory. One hundred and twenty college students were selected as participants. Emotional pictures (positive, negative and neutral) were selected from Chinese Affective Picture System (CAPS) as experimental materials...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163297/customer-orientation-and-leadership-in-the-health-service-sector-the-role-of-workplace-social-support
#18
Andreina Bruno, Giuseppina Dell'Aversana, Anna Zunino
Health care is a critical context due to unpredictable situations, demanding clients, workload, and intrinsic organizational complexity. One key to improve the quality of health services is connected to the shift in organization perspective of viewing patients as active consumers rather than passive users. Therefore, higher levels of customer orientation (CO) are expected to improve organizational service effectiveness. According to a cultural perspective to CO, the aim of the study was to explore how different leaders' behaviors (task-oriented and relationship-oriented) interact with CO of health organizations...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163261/a-sentence-repetition-task-for-catalan-speaking-typically-developing-children-and-children-with-specific-language-impairment
#19
Anna Gavarró
It is common to find that so-called minority languages enjoy fewer (if any) diagnostic tools than the so-called majority languages. This has repercussions for the detection and proper assessment of children with Specific Language Impairment (SLI) brought up in these languages. With a view to remedy this situation for Catalan, I developed a sentence repetition task to assess grammatical maturity in school-age children; in current practice, Catalan-speaking children are assessed with tests translated from Spanish, with disregard of the fact that the markers of SLI may differ substantially from one language to another, even between closely related languages...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163222/an-update-on-sec61-channel-functions-mechanisms-and-related-diseases
#20
REVIEW
Sven Lang, Stefan Pfeffer, Po-Hsien Lee, Adolfo Cavalié, Volkhard Helms, Friedrich Förster, Richard Zimmermann
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the protein translocon, which facilitates membrane integration or translocation of almost every newly synthesized polypeptide targeted to organelles of the endo- and exocytotic pathway. The translocon comprises the polypeptide-conducting Sec61 channel and several additional proteins and complexes that are permanently or transiently associated with the heterotrimeric Sec61 complex. This ensemble of proteins facilitates ER targeting of precursor polypeptides, modification of precursor polypeptides in transit through the Sec61 complex, and Sec61 channel gating, i...
2017: Frontiers in Physiology
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