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https://www.readbyqxmd.com/read/28329627/association-of-atopic-dermatitis-with-tobacco-smoke-exposure-a-systematic-review-and-meta-analysis
#1
Robert Kantor, Ashley Kim, Jacob Thyssen, Jonathan I Silverberg
Previous studies found conflicting results about whether exposure to tobacco smoke is associated with increased atopic dermatitis (AD). We examined this association by systematic review and meta-analysis of MEDLINE, EMBASE, Scopus, and Cochrane Library and identified 86 studies, including 680,176 patients from 39 countries. A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR). Subset analyses were performed for different ages (children or adult), regions, study designs (cross-sectional vs...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329446/in-vitro-intrinsic-permeability-a-transporter-independent-measure-of-caco-2-cell-permeability-in-drug-design-and-development
#2
Linda Fredlund, Susanne Winiwarter, Constanze Hilgendorf
In-vitro permeability data have a central place in absorption risk assessments in drug discovery and development. For compounds where active efflux impacts permeability in vitro, the inherent passive membrane permeability ("intrinsic permeability"), gives a concentration-independent measure of the compound's permeability. This work describes the validation of an in-vitro intrinsic permeability assay and application of the data in a predictive in-silico model. Apparent intrinsic permeability (Papp) across Caco-2 cell monolayers is determined in presence of an optimized cocktail of chemical inhibitors towards the three major efflux transporters ABCB1, ABCC2, and ABCG2...
March 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28329427/what-drives-perceived-work-intensity-in-neonatal-intensive-care-units-empirical-evidence-from-a-longitudinal-study
#3
Sandra Sülz, Kristina Langhammer, Michael Becker-Peth, Bernhard Roth
AIM: To investigate the drivers of perceived work intensity among neonatal intensive care unit nurses. BACKGROUND: The consequences of high work intensity have been studied extensively, yet setting-specific drivers have received less attention. DESIGN: Prospective, longitudinal and monocentric study design. METHODS: The study combined data from standardized diary surveys and passive observations of study nurses. Data were collected over a period of six months in 2015...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28329137/association-of-left-atrial-structure-and-function-and-incident-cardiovascular-disease-in-patients-with-diabetes-mellitus-results-from-multi-ethnic-study-of-atherosclerosis-mesa
#4
Timothy M Markman, Mohammadali Habibi, Bharath Ambale Venketash, Mytra Zareian, Colin Wu, Susan R Heckbert, David A Bluemke, Joao A C Lima
Aims: Diabetes mellitus (DM) is associated with the development of cardiovascular disease (CVD). Morphological changes in the left atrium (LA) may appear before symptoms. We aimed to investigate the association between cardiac magnetic resonance imaging (CMR) measured LA structure and function and incident CVD in asymptomatic individuals with DM. Methods and results: Tissue tracking CMR was used to measure LA size and phasic function (emptying fractions and strain) on all 536 Multi-Ethnic Study of Atherosclerosis (MESA) participants with DM and available CMR at baseline in 2000-2002...
February 28, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28329001/experimental-demonstration-of-the-possible-role-of-acanthamoeba-polyphaga-in-the-infection-and-disease-progression-in-buruli-ulcer-bu-using-icr-mice
#5
Bright K Azumah, Phyllis G Addo, Alfred Dodoo, Gordon Awandare, Lydia Mosi, Daniel A Boakye, Michael D Wilson
The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining...
2017: PloS One
https://www.readbyqxmd.com/read/28328659/burn-hand-or-finger-goniometric-measurements-sum-of-the-isolated-parts-and-the-composite-whole
#6
Reg Richard, Ingrid S Parry, Alexis Santos, W Scott Dewey
Accurate assessment of hand function following a burn is important for patient impairment determination. Goniometric measurement of hand or finger range of motion (ROM) is typically done measuring individual finger joints with the adjacent joint in extension (isolated) or measuring the joints in a fist position (composite). The purpose of this study was to compare if the total flexion motion of the summed angles of the metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints in burned hands were equal when performed in an isolated vs a composite manner...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28328346/efficacy-of-a-low-cost-heat-stable-oral-rotavirus-vaccine-in-niger
#7
Sheila Isanaka, Ousmane Guindo, Celine Langendorf, Amadou Matar Seck, Brian D Plikaytis, Nathan Sayinzoga-Makombe, Monica M McNeal, Nicole Meyer, Eric Adehossi, Ali Djibo, Bruno Jochum, Rebecca F Grais
Background Each year, rotavirus gastroenteritis is responsible for about 37% of deaths from diarrhea among children younger than 5 years of age worldwide, with a disproportionate effect in sub-Saharan Africa. Methods We conducted a randomized, placebo-controlled trial in Niger to evaluate the efficacy of a live, oral bovine rotavirus pentavalent vaccine (BRV-PV, Serum Institute of India) to prevent severe rotavirus gastroenteritis. Healthy infants received three doses of the vaccine or placebo at 6, 10, and 14 weeks of age...
March 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28327157/factors-influencing-implementation-of-a-patient-decision-aid-in-a-developing-country-an-exploratory-study
#8
Wen Ting Tong, Yew Kong Lee, Chirk Jenn Ng, Ping Yein Lee
BACKGROUND: Most studies on barriers and facilitators to implementation of patient decision aids (PDAs) are conducted in the west; hence, the findings may not be transferable to developing countries. This study aims to use a locally developed insulin PDA as an exemplar to explore the barriers and facilitators to implementing PDAs in Malaysia, an upper middle-income country in Asia. METHODS: Qualitative methodology was adopted. Nine in-depth interviews (IDIs) and three focus group discussions (FGDs) were conducted with policymakers (n = 6), medical officers (n = 13), diabetes educators (n = 5) and a nurse, who were involved in insulin initiation management at an academic primary care clinic...
March 21, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28327133/improved-knee-biomechanics-among-patients-reporting-a-good-outcome-in-knee-related-quality-of-life-one-year-after-total-knee-arthroplasty
#9
Josefine E Naili, Per Wretenberg, Viktor Lindgren, Maura D Iversen, Margareta Hedström, Eva W Broström
BACKGROUND: It is not well understood why one in five patients report poor outcomes following knee arthroplasty. This study evaluated changes in knee biomechanics, and perceived pain among patients reporting either a good or a poor outcome in knee-related quality of life after total knee arthroplasty. METHODS: Twenty-eight patients (mean age 66 (SD 7) years) were included in this prospective study. Within one month of knee arthroplasty and one year after surgery, patients underwent three-dimensional (3D) gait analysis, completed the Knee Injury and Osteoarthritis Outcome Score (KOOS), and rated perceived pain using a visual analogue scale...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28326821/understanding-self-harm-in-older-people-a-systematic-review-of-qualitative-studies
#10
Anne Pamela Frances Wand, Carmelle Peisah, Brian Draper, Henry Brodaty
OBJECTIVE: Rates of suicide in older adults are generally higher than other age groups. Although risk factors for suicide attempts, and self-harm more generally, in this population are well-characterised, many of these vulnerabilities are common to older people and individual motivations are less well understood. Qualitative research may reveal more about the underlying thought processes, meaning and experiences of older people who self-harm. METHODS: A systematic review of qualitative studies examining the reasons why older people have self-harmed was undertaken by searching databases and screening the reference lists of articles...
March 22, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28326625/alantolactone-and-isoalantolactone-prevent-amyloid-%C3%AE-25-35-induced-toxicity-in-mouse-cortical-neurons-and-scopolamine-induced-cognitive-impairment-in-mice
#11
Ji Yeon Seo, Soon Sung Lim, Jiyoung Kim, Ki Won Lee, Jong-Sang Kim
Given the evidence for detoxifying/antioxidant enzyme-inducing activities by alantolactone (AL) and isoalantolactone (IAL), the purpose of this study was to investigate the effects of AL and IAL on Aβ25-35 -induced cell death in mouse cortical neuron cells and to determine their effects on scopolamine-induced amnesia in mice. Our data demonstrated that both compounds effectively attenuated the cytotoxicity of Aβ25-35 (10 μM) in neuronal cells derived from the mouse cerebral cortex. It was also found that the production of intracellular reactive oxygen species, including superoxide anion induced by Aβ25-35 , was inhibited...
March 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28326615/using-passive-sampling-and-zebrafish-to-identify-developmental-toxicants-in-complex-mixtures
#12
Alan J Bergmann, Robert L Tanguay, Kim A Anderson
Using effects-directed analysis (EDA), we investigate associations previously observed between PAHs and embryotoxicity in field-deployed low-density polyethylene (LDPE). We conducted EDA using a zebrafish embryo assay and iterative fractionation of extracts of LDPE that were deployed in Portland Harbor Superfund Megasite, Oregon. Whole extracts induced toxicity including mortality, edema, and notochord distortion at EC20s of approximately 100, 100, and 10 mg LDPE/mL, respectively. Through fractionation, we determined that PAHs at concentrations similar to previous research did not contribute markedly to toxicity...
March 22, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28325539/n2-gas-egress-from-patients-airways-during-ln2-spray-cryotherapy
#13
John P O'Connor, Brian M Hanley, Thomas I Mulcahey, Ellen E Sheets, Kacey W Shuey
Spray cryotherapy using liquid nitrogen (LN2) is a general surgical tool used to ablate benign or malignant lesions. Adequate egress of the gaseous nitrogen (N2) generated during this process must be provided for safe use when LN2 is used within the body rather than topically. When delivered to either the gastrointestinal tract (requiring active venting via a suction tube) or body cavities open to room barometric pressure (such as lung airways) allowing for passive venting, the N2 gas generated from the boiling process must be evacuated...
March 18, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28325477/nano-sized-soluplus%C3%A2-polymeric-micelles-enhance-the-induction-of-tetanus-toxin-neutralising-antibody-response-following-transcutaneous-immunisation-with-tetanus-toxoid
#14
Manolya Saydam, Woei Ping Cheng, Nathan Palmer, Robert Tierney, Robert Francis, Kirsty MacLellan-Gibson, Ambreen Khan, Fatme Mawas
The use of Soluplus® polymeric micelles as a novel adjuvant for tetanus toxoid (TTxd) in transcutaneous immunisation was evaluated. TTxd was added to Soluplus® polymeric micelles to form TTxd-Soluplus® nano-aggregates with a size of 68nm. Non-adjuvanted TTxd commonly induces very poor antibody response by the transcutaneous route. However, in this study, the use of TTxd-Soluplus® resulted in a significant increase in the antibody response to TTxd, which was similar to that induced in the presence of CPG-oligodeoxynucleotides (CPG-ODNs) adjuvant...
March 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28325449/tcontrol-a-mobile-app-to-follow-up-tobacco-quitting-patients
#15
Marc Pifarré, Adrián Carrera, Jordi Vilaplana, Josep Cuadrado, Sara Solsona, Francesc Abella, Francesc Solsona, Rui Alves
BACKGROUND AND OBJECTIVE: Tobacco smoking is a major risk factor for a wide range of respiratory and circulatory diseases in active and passive smokers. Well-designed campaigns are raising awareness to the problem and an increasing number of smokers seeks medical assistance to quit their habit. In this context, there is the need to develop mHealth Apps that assist and manage large smoke quitting programs in efficient and economic ways. OBJECTIVES: Our main objective is to develop an efficient and free mHealth app that facilitates the management of, and assistance to, people who want to quit smoking...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28325446/segmentation-of-elastic-fibres-in-images-of-vessel-wall-sections-stained-with-weigert-s-resorcin-fuchsin
#16
Pablo Hernández-Morera, Carlos M Travieso-González, Irene Castaño-González, Blanca Mompeó-Corredera, Francisco Ortega-Santana
BACKGROUND AND OBJECTIVE: The elastic fibres are an essential component of the extracellular matrix in blood vessel walls that allows a long-range of deformability and passive recoil without energy input. The quantitative determination of elastic fibres will provide information on the state of the vascular wall and to determine the role and behaviour of this key structural element in different physiological and pathological vascular processes. METHODS: We present a segmentation method to identify and quantify elastic fibres based on a local threshold technique and some morphological characteristics measured on the segmented objects that facilitate the discrimination between elastic fibres and other image components...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28325219/homeopathy-outperforms-antibiotics-treatment-in-juvenile-scallop-argopecten-ventricosus-effects-on-growth-survival-and-immune-response
#17
José Manuel Mazón-Suástegui, Milagro García-Bernal, Pedro Enrique Saucedo, Ángel Campa-Córdova, Fernando Abasolo-Pacheco
BACKGROUND: Mortality from vibriosis in mollusk production is attributed to pathogenic bacteria, particularly Vibrio alginolyticus. Use of increasingly potent antibiotics has led to bacterial resistance and increased pathogenicity. Alternatives in sanitation, safety, and environmental sustainability are currently under analysis. To-date, homeopathy has been investigated in aquaculture of freshwater fish, but not in marine mollusks. The effect of the homeopathic complexes in the growth, survival, and immune response of the Catarina scallop Argopecten ventricosus were assessed...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28325000/mechanomyography-signals-in-spastic-muscle-and-the-correlation-with-the-modified-ashworth-scale
#18
E L Santos, M C Santos, E Krueger, G N Nogueira-Neto, P Nohama
The modified Ashworth scale (MAS) is the most widely used measurement technique to assess levels of spasticity. In MAS, the evaluator graduates spasticity considering his/her subjective analysis of the muscular endurance during passive stretching. Therefore, it is a subjective scale. Mechanomyography (MMG) allows registering the vibrations generated by muscle contraction and stretching events that propagate through the tissue until the surface of the skin. With this in mind, this study aimed to investigate possible correlations between MMG signal and muscle spasticity levels determined by MAS...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324974/altered-viscoelastic-properties-of-stroke-affected-muscles-estimated-using-ultrasound-shear-waves-preliminary-data
#19
Ghulam Rasool, Allison B Wang, William Z Rymer, Sabrina S M Lee
As a result of a brain injury such as stroke, the skeletal muscles may undergo numerous structural and functional alterations. These abnormal changes are linked to muscle weakness, joint contracture, and abnormal muscle tone and eventually, result in motor impairment. A subset of these alterations affects passive muscle stiffness, i.e., viscoelastic properties. However, in vivo estimation of changes in viscoelastic properties is a challenging task. Here, we used the shear wave velocity, estimated through ultrasound SuperSonic imaging (SSI), as a surrogate for viscoelastic properties...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324973/force-controlled-ultrasound-to-measure-passive-mechanical-properties-of-muscle-in-duchenne-muscular-dystrophy
#20
Anne J Pigula, Jim S Wu, Matthew W Gilbertson, Basil T Darras, Seward B Rutkove, Brian W Anthony
The purpose of this study is to assess differences in skeletal muscle compressibility between patients with Duchenne muscular dystrophy (DMD) and normal subjects. The transverse passive mechanical properties of muscle, particularly those related to stiffness and elasticity, can be measured using force-controlled ultrasound. We acquired ultrasound videos of muscle compression under known pressures in the biceps and quadriceps in 23 boys with DMD and 20 age-matched healthy controls. We calculated the bulk linear spring constant, nonlinear stress-strain response, and average Young's modulus for each...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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