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https://www.readbyqxmd.com/read/27922176/dipeptidyl-peptidase-4-inhibitor-sitagliptin-reduces-inflammation-fibrosis-and-preserves-diastolic-function-in-a-rat-model-of-heart-failure-with-preserved-ejection-fraction
#1
Grazia Esposito, Donato Cappetta, Rosa Russo, Alessia Rivellino, Loreta Pia Ciuffreda, Fiorentina Roviezzo, Elena Piegari, L Liberato Berrino, Francesco Rossi, Antonella De Angelis, Konrad Urbanek
BACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFpEF) is a systemic syndrome driven by co-morbidities and its pathophysiology is poorly understood. Several studies suggesting that dipeptidyl peptidase 4 (DPP4) might be involved in the pathophysiology of heart failure prompted experimental and clinical investigations of DPP4 inhibitors on cardiovascular system. The aim of our study was to determine whether DPP4 inhibitor sitagliptin (SITA) affects the progression of HFpEF independently from the effects on glycaemia...
December 6, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27922048/passivation-and-characterization-of-charge-defects-in-ambipolar-silicon-quantum-dots
#2
Paul C Spruijtenburg, Sergey V Amitonov, Filipp Mueller, Wilfred G van der Wiel, Floris A Zwanenburg
In this Report we show the role of charge defects in the context of the formation of electrostatically defined quantum dots. We introduce a barrier array structure to probe defects at multiple locations in a single device. We measure samples both before and after an annealing process which uses an Al2O3 overlayer, grown by atomic layer deposition. After passivation of the majority of charge defects with annealing we can electrostatically define hole quantum dots up to 180 nm in length. Our ambipolar structures reveal amphoteric charge defects that remain after annealing with charging energies of 10 meV in both the positive and negative charge state...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921342/cross-protection-against-vibrio-cholerae-infection-by-monoclonal-antibodies-against-vibrio-vulnificus-rtxa1-martxvv
#3
Tae Hee Lee, Sun-Shin Cha, Chang-Seop Lee, Joon Haeng Rhee, Hye Ryun Woo, Kyung Min Chung
Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTXVc , inhibited CPD autocleavage in vitro; this process is involved in V...
November 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27921170/effect-of-photon-initiated-photoacoustic-streaming-passive-ultrasonic-and-sonic-irrigation-techniques-on-dentinal-tubule-penetration-of-irrigation-solution-a-confocal-microscopic-study
#4
Merve Akcay, Hakan Arslan, Merve Mese, Nazlı Durmus, Ismail Davut Capar
OBJECTIVES: The aim of this in vitro study was to evaluate the efficacy of different irrigation techniques including laser-activated irrigation using an erbium:yttrium-aluminum-garnet (Er:YAG) laser with a novel tip design (photon-induced photoacoustic streaming (PIPS)), Er:YAG laser with Preciso tip, sonic activation, and passive ultrasonic activation on the final irrigation solution penetration into dentinal tubules by using a laser scanning confocal microscope. MATERIAL AND METHODS: In this study, 65 extracted single-rooted human mandibular premolars were instrumented up to size 40 and randomly divided into 5 groups (n = 13) based on the activation technique of the final irrigation solution as follows: conventional irrigation (control group), sonic activation, passive ultrasonic activation, Er:YAG-PIPS tip activation, and Er:YAG-Preciso tip activation...
December 5, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27921116/-the-pressure-equalizing-function-of-the-eustachian-tube-evaluation-in-a%C3%A2-hypo-hyperbaric-pressure-chamber
#5
S Jansen, M F Meyer, K-B Hüttenbrink, D Beutner
BACKGROUND: The Eustachian tube connects the tympanic cavity (cavum tympani) and the nasopharynx, and enables pressure equalization between the middle ear and ambient pressure. Functional pressure compensation is very important for flying and diving in particular, due to non-physiologically large pressure differences. OBJECTIVE: Evaluation of the pressure-equalizing function of the Eustachian tube is still a clinical challenge. This review article evaluates the existing data...
December 5, 2016: HNO
https://www.readbyqxmd.com/read/27920822/anti-anaphylactic-effects-of-trichilia-monadelpha-thonn-j-j-de-wilde-extracts-on-rodent-models-of-anaphylaxis
#6
Inemesit Okon Ben, Eric Woode, George Asumeng Koffuor, Emmanuel Akomanin Asiamah
Effects of petroleum ether and ethanolic extracts of Trichilia monadelpha stem bark (PEE and EAE) on compound 48/80-induced systemic and passive anaphylaxis were determined. Survival rate, extravasation, degranulation of mast cells, and secretion of tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured after pre-treatment with extracts (10-100 mg/kg) and disodium chromoglycate (2.5-250 μg/kg) and induction of anaphylaxis in C57BL/6 mice or Sprague-Dawley rats with compound 48/80. Histopathological assessments were made from skin biopsies of rats...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27920177/surveillance-for-chikungunya-and-dengue-during-the-first-year-of-chikungunya-virus-circulation-in-puerto-rico
#7
Tyler M Sharp, Kyle R Ryff, Luisa Alvarado, Wun-Ju Shieh, Sherif R Zaki, Harold S Margolis, Brenda Rivera-Garcia
After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance, 6472 were tested for evidence of CHIKV infection, and results for 4399 (68%) were positive. Of 250 participants in household cluster investigations, 70 (28%) had evidence of recent CHIKV infection. Enhanced surveillance for chikungunya at 2 hospitals identified 1566 patients who tested positive for CHIKV, of whom 10...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#8
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over the conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses, greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
December 2, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27919226/molar-loss-and-powder-diet-leads-to-memory-deficit-and-modifies-the-mrna-expression-of-brain-derived-neurotrophic-factor-in-the-hippocampus-of-adult-mice
#9
Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa, Kazuhiro Tsuga
BACKGROUND: It is known that tooth loss is known to be a risk factor for Alzheimer's disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with tooth loss or soft diet in young animal model, and that BDNF expression is decreased in patients with Alzheimer's disease. However, single or combined effect of tooth loss and/or soft diet on brain function has not fully understood. Here we examined the effect of molar loss and powder diet on memory ability and the expression of BDNF mRNA in the hippocampus of adult C57BL/6J mice...
December 5, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27918654/cold-water-immersion-and-contrast-water-therapy-do-not-improve-short-term-recovery-following-resistance-training
#10
Christos K Argus, James R Broatch, Aaron C Petersen, Remco Polman, David J Bishop, Shona Halson
PURPOSE: An athlete's ability to recover quickly is important when there is limited time between training and competition. As such, recovery strategies are commonly used to expedite the recovery process. The purpose of this study was to determine the effectiveness of both cold water immersion (CWI) and contrast water therapy (CWT) compared to control on short-term recovery (<4h) following a single full-body resistance training session. METHODS: Thirteen males (age, 26 ± 5 years; weight, 79 ± 7 kg; height, 177 ± 5 cm) were assessed for perceptual (fatigue and soreness) and performance measures (maximal voluntary isometric contraction (MVC) of the knee extensors, weighted and unweighted countermovement jumps) prior to and immediately following the training session...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918567/topologically-protected-bound-states-in-photonic-parity-time-symmetric-crystals
#11
S Weimann, M Kremer, Y Plotnik, Y Lumer, S Nolte, K G Makris, M Segev, M C Rechtsman, A Szameit
Parity-time (PT)-symmetric crystals are a class of non-Hermitian systems that allow, for example, the existence of modes with real propagation constants, for self-orthogonality of propagating modes, and for uni-directional invisibility at defects. Photonic PT-symmetric systems that also support topological states could be useful for shaping and routing light waves. However, it is currently debated whether topological interface states can exist at all in PT-symmetric systems. Here, we show theoretically and demonstrate experimentally the existence of such states: states that are localized at the interface between two topologically distinct PT-symmetric photonic lattices...
December 5, 2016: Nature Materials
https://www.readbyqxmd.com/read/27918416/a-touch-sensing-technique-using-the-effects-of-extremely-low-frequency-fields-on-the-human-body
#12
Hatem Elfekey, Hany Ayad Bastawrous, Shogo Okamoto
Touch sensing is a fundamental approach in human-to-machine interfaces, and is currently under widespread use. Many current applications use active touch sensing technologies. Passive touch sensing technologies are, however, more adequate to implement low power or energy harvesting touch sensing interfaces. This paper presents a passive touch sensing technique based on the fact that the human body is affected by the surrounding extremely low frequency (ELF) electromagnetic fields, such as those of AC power lines...
December 2, 2016: Sensors
https://www.readbyqxmd.com/read/27918261/indoor-development-of-aedes-aegypti-in-germany-2016
#13
Helge Kampen, Stephanie Jansen, Jonas Schmidt-Chanasit, Doreen Walther
In spring 2016, a German traveller returning from Martinique cultivated imported plant offsets in her home, and accidentally bred Aedes aegypti. Thirteen adult mosquito specimens submitted for identification and the traveller were tested for Zika, dengue and chikungunya virus infections, with negative results. The detection of Ae. aegypti by the 'Mueckenatlas' project demonstrates the value of this passive surveillance scheme for potential public health threats posed by invasive mosquitoes in Germany.
November 24, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27918033/investigating-the-behavior-of-various-cocatalysts-on-lataon2-photoanode-for-visible-light-water-splitting
#14
Wenping Si, Daniele Pergolesi, Fatima Haydous, Aline Fluri, Alexander Wokaun, Thomas Lippert
We performed a comparative study on the photoelectrochemical performance of LaTaON2 loaded with NiOx, Ni0.7Fe0.3Ox, CoOx and IrOx as cocatalysts. Ni-based oxides lead to the highest improvement on the photoelectrochemical performance, while CoOx and IrOx also enhance the performance though to a lower extent, but they simultaneously introduce more pseudocapacitive current thus resulting in an inefficient utilization of the photo-generated holes. Repetitive voltage cycling between 1.0 VRHE and 1.6 VRHE transforms the NiOx and Ni0...
December 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27918030/solvation-behavior-of-carbonate-based-electrolytes-in-sodium-ion-batteries
#15
Arthur V Cresce, Selena M Russell, Oleg Borodin, Joshua A Allen, Marshall A Schroeder, Michael Dai, Jing Peng, Mallory P Gobet, Steven G Greenbaum, Reginald E Rogers, Kang Xu
Sodium ion batteries are on the cusp of being a commercially available technology. Compared to lithium ion batteries, sodium ion batteries can potentially offer an attractive dollar-per-kilowatt-hour value, though at the penalty of reduced energy density. As a materials system, sodium ion batteries present a unique opportunity to apply lessons learned in the study of electrolytes for lithium ion batteries; specifically, the behavior of the sodium ion in an organic carbonate solution and the relationship of ion solvation with electrode surface passivation...
December 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27917938/high-quality-and-large-size-topological-insulator-bi2te3-gold-saturable-absorber-mirror-for-mode-locking-fiber-laser
#16
Hou-Ren Chen, Chih-Ya Tsai, Hsin-Ming Cheng, Kuei-Huei Lin, Po-Hsiu Yen, Chyong-Hua Chen, Wen-Feng Hsieh
A novel high-quality, large-size, reflection-type topological insulator Bi2Te3-Gold (BG) film-based nonlinear optical modulator has been successfully fabricated as a two-dimensional saturable absorber mirror (SAM) by pulsed laser deposition (PLD). This BG-SAM possesses saturation fluence of 108.3 μJ/cm(2), modulation depth (ΔR) of 6.5%, non-saturable loss of 38.4%, high damage threshold above 1.354 mJ/cm(2) and excellent uniformity providing for the generation of passive mode-locked (ML) pulses for erbium-doped fiber lasers (EDFLs) on a large sample area...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917775/the-mass-miniature-chest-radiography-programme-in-cape-town-south-africa-1948-1994-the-impact-of-active-tuberculosis-case-finding
#17
S M Hermans, J R Andrews, L-G Bekker, R Wood
BACKGROUND: Tuberculosis (TB) control programmes rely mainly on passive detection of symptomatic individuals. The resurgence of TB has rekindled interest in active case finding. Cape Town (South Africa) had a mass miniature radiography (MMR) screening programme from 1948 to 1994. OBJECTIVE: To evaluate screening coverage, yield and secular trends in TB notifications during the MMR programme. METHODS: We performed an ecological analysis of the MMR programme and TB notification data from the City of Cape Town Medical Officer of Health reports for 1948 - 1994...
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27917161/the-interaction-between-plants-and-bacteria-in-the-remediation-of-petroleum-hydrocarbons-an-environmental-perspective
#18
REVIEW
Panagiotis Gkorezis, Matteo Daghio, Andrea Franzetti, Jonathan D Van Hamme, Wouter Sillen, Jaco Vangronsveld
Widespread pollution of terrestrial ecosystems with petroleum hydrocarbons (PHCs) has generated a need for remediation and, given that many PHCs are biodegradable, bio- and phyto-remediation are often viable approaches for active and passive remediation. This review focuses on phytoremediation with particular interest on the interactions between and use of plant-associated bacteria to restore PHC polluted sites. Plant-associated bacteria include endophytic, phyllospheric, and rhizospheric bacteria, and cooperation between these bacteria and their host plants allows for greater plant survivability and treatment outcomes in contaminated sites...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27917117/training-on-working-memory-and-inhibitory-control-in-young-adults
#19
Maria J Maraver, M Teresa Bajo, Carlos J Gomez-Ariza
Different types of interventions have focused on trying to improve Executive Functions (EFs) due to their essential role in human cognition and behavior regulation. Although EFs are thought to be diverse, most training studies have targeted cognitive processes related to working memory (WM), and fewer have focused on training other control mechanisms, such as inhibitory control (IC). In the present study, we aimed to investigate the differential impact of training WM and IC as compared with control conditions performing non-executive control activities...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27916920/dielectrically-loaded-cylindrical-resonator-based-wireless-passive-high-temperature-sensor
#20
Jijun Xiong, Guozhu Wu, Qiulin Tan, Tanyong Wei, Dezhi Wu, Sanmin Shen, Helei Dong, Wendong Zhang
The temperature sensor presented in this paper is based on a microwave dielectric resonator, which uses alumina ceramic as a substrate to survive in harsh environments. The resonant frequency of the resonator is determined by the relative permittivity of the alumina ceramic, which monotonically changes with temperature. A rectangular aperture etched on the surface of the resonator works as both an incentive and a coupling device. A broadband slot antenna fed by a coplanar waveguide is utilized as an interrogation antenna to wirelessly detect the sensor signal using a radio-frequency backscattering technique...
December 1, 2016: Sensors
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