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https://www.readbyqxmd.com/read/28918305/single-center-experience-with-percutaneous-extraction-of-cardiac-implantable-electric-devices
#1
Ayako Okada, Morio Shoda, Hiroaki Tabata, Wataru Shoin, Hideki Kobayashi, Takahiro Okano, Koji Yoshie, Yasutaka Oguchi, Takahiro Takeuchi, Ken Kato, Koichiro Kuwahara
BACKGROUND: The estimated incidence of infected cardiac implantable electric devices (CIED) has recently increased to 1-2% in Japan. Extraction of long-term implanted devices is generally difficult. There are few reports about lead extraction in Japan. We describe our experience with and outcomes of lead extraction using excimer lasers, mechanical sheaths, and manual extraction. METHODS: We retrospectively analyzed the characteristics, types of devices, and indications for extraction in 29 patients with 67 leads who required CIED lead extraction at Shinshu University Hospital between April 2014 and October 2016...
September 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28918116/atherosclerotic-disease-and-its-relationship-to-lumbar-degenerative-disc-disease-facet-arthritis-and-stenosis-with-computed-tomography-angiography
#2
William J Beckworth, John F Holbrook, Lisa G Foster, Laura A Ward, James R Welle
BACKGROUND: The intervertebral disc is the largest avascular structure in the body. It relies on passive diffusion from arteries at the periphery of the disc for nutrition. Prior studies have suggested a correlation between vascular disease and lumbar degenerative disc disease (DDD) but the association with facet arthritis and stenosis has not been evaluated. OBJECTIVE: To evaluate the degree of lumbar artery stenosis, aortic atherosclerosis on computed tomography angiography (CTAs) and its relationship to lumbar DDD, facet arthritis and spinal canal stenosis...
September 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28917975/the-memory-ameliorating-effects-of-dhp1402-an-herbal-mixture-on-cholinergic-blockade-induced-cognitive-dysfunction-in-mice
#3
Haneul Kim, Hyung Eun Lee, In Ho Jung, Se Jin Jeon, Jiabao Zhang, Yubeen Kwon, Dae Sik Jang, Jong Hoon Ryu
ETHNOPHARMACOLOGICAL RELEVANCE: Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F Chow (rhamnaceae) and Codonopsis lanceolata (Siedbold & Zucc.) Benth. & Hook.f. ex Trautv. (campanulaceae), compositions of DHP1402, have long been used for treating anti-dementia or hypomnesia as folk medicine. AIM OF THE STUDY: It has been reported that Z. jujuba var. spinosa and C. lanceolata are effective on cognitive function with different mechanism of action. Therefore, in the present study, we evaluated the synergistic effects of Ziziphus jujuba var...
September 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28917586/dosimetric-comparison-to-the-heart-and-cardiac-substructure-in-a-large-cohort-of-esophageal-cancer-patients-treated-with-proton-beam-therapy-or-intensity-modulated-radiation-therapy
#4
Yutaka Shiraishi, Cai Xu, Jinzhong Yang, Ritsuko Komaki, Steven H Lin
PURPOSE: To compare heart and cardiac substructure radiation exposure using intensity-modulated radiotherapy (IMRT) vs. proton beam therapy (PBT) for patients with mid- to distal esophageal cancer who received chemoradiation therapy. METHODS AND MATERIALS: We identified 727 esophageal cancer patients who received IMRT (n=477) or PBT (n=250) from March 2004 to December 2015. All patients were treated to 50.4Gy with IMRT or to 50.4 cobalt Gray equivalents with PBT...
September 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28917533/nanoparticles-of-a-polyaspartamide-based-brush-copolymer-for-modified-release-of-sorafenib-in-vitro-and-in-vivo-evaluation
#5
Melchiorre Cervello, Giovanna Pitarresi, Antonella Bavuso Volpe, Barbara Porsio, Daniele Balasus, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Guido Ruggero Loria, Stefano Puleo, Gaetano Giammona
In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib for the treatment of hepatocellular carcinoma (HCC). A synthetic brush copolymer, named PHEA-BIB-ButMA (PBB), was synthesized by Atom Trasnfer Radical Polymerization (ATRP) starting from the α-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) and poly butyl methacrylate (ButMA). Empty and sorafenib loaded PBB NPs were, then, produced by using a dialysis method and showed spherical morphology, colloidal size, negative ζ potential and the ability to allow a sustained sorafenib release in physiological environment...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28917530/overcoming-key-biological-barriers-to-cancer-drug-delivery-and-efficacy
#6
Susy M Kim, Peggy H Faix, Jan E Schnitzer
Poor delivery efficiency continues to hamper the effectiveness of cancer therapeutics engineered to destroy solid tumors using different strategies such as nanocarriers, targeting agents, and matching treatments to specific genetic mutations. All contemporary anti-cancer agents are dependent upon passive transvascular mechanisms for their delivery into solid tumors. The therapeutic efficacies of our current drug arsenal could be significantly improved with an active delivery strategy. Here, we discuss how drug delivery and therapeutic efficacy is greatly hindered by barriers presented by the vascular endothelial cell layer and by the aberrant nature of tumor blood vessels in general...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28917121/a-formal-description-of-middle-ear-pressure-regulation
#7
William J Doyle
INTRODUCTION: Middle ear (ME) pressure-regulation (MEPR) is a homeostatic mechanism that maintains the ME-environment pressure-gradient (MEEPG) within a range optimized for "normal" hearing. OBJECTIVE: Describe MEPR using equations applicable to passive, inter-compartmental gas-exchange and determine if the predictions of that description include the increasing ME pressure observed under certain conditions and interpreted by some as evidencing gas-production by the ME mucosa...
August 24, 2017: Hearing Research
https://www.readbyqxmd.com/read/28916870/efficacy-and-immunogenicity-of-recombinant-swinepox-virus-expressing-the-truncated-s-protein-of-a-novel-isolate-of-porcine-epidemic-diarrhea-virus
#8
Xiaomin Yuan, Huixing Lin, Bin Li, Kongwang He, Hongjie Fan
Porcine epidemic diarrhea virus (PEDV) causes significant loss to the swine industry. The emergence of novel PEDV strains in recent years has decreased the effectiveness of PEDV vaccines. We have developed a live recombinant vaccine, a swinepox virus vector that expresses a truncated S protein (rSPV-St) from a recent PEDV strain, SQ2014, and evaluated its immunogenicity and effectiveness in a swine model. Vaccination of swine with rSPV-St elicited a robust antibody response specific for the homologous PEDV SQ2014...
September 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28916665/integrin-%C3%AE-4-overexpression-on-rat-mesenchymal-stem-cells-enhances-transmigration-and-reduces-cerebral-embolism-after-intracarotid-injection
#9
Li-Li Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina, Laura Tolppanen, Jussi Rytkönen, Tuulia Huhtala, Jing-Wei Mu, Leonard Khiroug, Johannes Boltze, Jukka Jolkkonen
BACKGROUND AND PURPOSE: Very late antigen-4 (integrin α4β1)/vascular cell adhesion molecule-1 mediates leukocyte trafficking and transendothelial migration after stroke. Mesenchymal stem cells (MSCs) typically express integrin β1 but insufficient ITGA4 (integrin α4), which limits their homing after intravascular transplantation. We tested whether ITGA4 overexpression on MSCs increases cerebral homing after intracarotid transplantation and reduces MSC-borne cerebral embolism. METHODS: Rat MSCs were lentivirally transduced to overexpress ITGA4...
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28916244/-how-do-immigrant-women-access-health-services-in-the-basque-country-perceptions-of-health-professionals
#10
Iratxe Pérez-Urdiales, Isabel Goicolea
OBJECTIVE: To determine the perception of health professionals working in alternative health centres on the barriers and facilitators in the access by immigrant women to general public health services and sexual and reproductive health in the Basque Country. LOCATION: Basque Country. DESIGN: Analysis of qualitative content based on 11 individual interviews. PARTICIPANTS: Health professionals working in alternative health centres of Primary Care and sexual and reproductive health...
September 12, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28916200/islanding-detection-scheme-based-on-adaptive-identifier-signal-estimation-method
#11
M Bakhshi, R Noroozian, G B Gharehpetian
This paper proposes a novel, passive-based anti-islanding method for both inverter and synchronous machine-based distributed generation (DG) units. Unfortunately, when the active/reactive power mismatches are near to zero, majority of the passive anti-islanding methods cannot detect the islanding situation, correctly. This study introduces a new islanding detection method based on exponentially damped signal estimation method. The proposed method uses adaptive identifier method for estimating of the frequency deviation of the point of common coupling (PCC) link as a target signal that can detect the islanding condition with near-zero active power imbalance...
September 12, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28916095/review-novel-sensing-strategies-for-bacterial-detection-based-on-active-and-passive-methods-driven-by-external-field
#12
REVIEW
Shiho Tokonami, Takuya Iida
For sustainable human life, biosensing systems for contaminants or disease-causing bacteria are crucial for food security, environmental improvement, and disease prevention. With an aim of enhancing the sensitivity and detection speed, many researchers have developed efficient detection methods for target bacteria. In this review, we discuss recent topics related to active and passive bacterial detection methods, including (1) optical approaches with unique functional nano- and micro-structures, and (2) electrical approaches involving mechanical modulation and electrochemical reactions...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916032/polymer-inclusion-membranes-pims-in-chemical-analysis-a-review
#13
REVIEW
M Inês G S Almeida, Robert W Cattrall, Spas D Kolev
This review highlights the increasing interest in polymer inclusion membranes (PIMs) in analytical chemistry as they are adapted to new and novel applications. PIMs are polymer-based liquid membranes and were first introduced 50 years ago as the sensing membranes in ion-selective electrodes and optodes. More recently however, PIMs have been used for other applications in analytical chemistry such as for sample separation, sample pre-concentration, electro-driven extraction, and passive sampling, and have also been incorporated into on-line and automated analysis systems...
September 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916001/giardia-and-cryptosporidium-infections-in-neonatal-reindeer-calves-relation-to-the-acute-phase-response
#14
Tarmo Niine, Kristel Peetsalu, Mauri Nieminen, Antti Oksanen, Timo Soveri, Toomas Orro
This longitudinal observational study was conducted to investigate the spontaneous effect of Giardia and Cryptosporidium infections on acute phase response (APR) in reindeer calves (Rangifer tarandus tarandus) in Finnish Lapland. Serum (n=609) and faecal samples (n=366) were collected from 54 reindeer calves aged zero to 33days. The samples were analysed for Giardia, Cryptosporidium, acute phase proteins (APP) and γ-globulins. Linear regression models were used to investigate associations of early Giardia infection (before 12days of life) with the response of APPs and acquiring of passive immunity...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28915917/translocation-of-molecular-chaperones-to-the-titin-springs-is-common-in-skeletal-myopathy-patients-and-affects-sarcomere-function
#15
Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O Fürst, Matthias Vorgerd, Wolfgang A Linke
Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this study, we observed increased passive tension (PT) of skinned myofibers from patients with myofibrillar myopathy (MFM) caused by FLNC mutations (MFM-filaminopathy) and limb-girdle muscular dystrophy type-2A due to CAPN3 mutations (LGMD2A), compared to healthy control myofibers. Because the giant protein titin determines myofiber PT, we measured its molecular size and the titin-to-myosin ratio, but found no differences between myopathies and controls...
September 15, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28915687/features-and-risk-factors-of-carotid-atherosclerosis-in-a-population-with-high-stroke-incidence-in-china
#16
Yanqiu Zhang, Lingling Bai, Min Shi, Hongyan Lu, Yanan Wu, Jun Tu, Jingxian Ni, Jinghua Wang, Li Cao, Ping Lei, Xianjia Ning
Epidemiological studies have reported associations between traditional cardiovascular risk factors and carotid intima-media thickness (CIMT) or carotid plaque. However, definite risk factors at different phases of carotid atherosclerosis remain controversial. We aimed to explore risk factors and characteristics of carotid atherosclerosis at different stages in a low-income population with a high incidence of stroke in China. Between April 2014 and January 2015, we recruited 3789 stroke-free and cardiovascular disease-free residents aged ≥ 45 years...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915547/persistence-mobility-and-bioavailability-of-emerging-organic-contaminants-discharged-from-sewage-treatment-plants
#17
Kristin M Blum, Patrik L Andersson, Lutz Ahrens, Karin Wiberg, Peter Haglund
Little is known about the impact of emissions of micropollutants from small and large-scale sewage treatment plants (STPs) on drinking water source areas. We investigated a populated catchment that drains into Lake Mälaren, which is the drinking water source for around 2 million people including the inhabitants of Stockholm, Sweden. To assess the persistence, mobility, bioavailability and bioaccumulation of 32 structurally diverse emerging organic contaminants, sediment, integrated passive and grab water samples were collected along the catchment of the River Fyris, Sweden...
September 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28915502/to-stop-or-not-to-stop-contrasting-compliant-and-non-compliant-driver-behaviour-at-rural-rail-level-crossings
#18
Vanessa Beanland, Paul M Salmon, Ashleigh J Filtness, Michael G Lenné, Neville A Stanton
Many rail level crossings (RLXs) have only passive protection, such as static signs instructing road users to stop, yield, or look for trains. Stop signs have been suggested as a low-cost option to improve safety at passive RLXs, as requiring drivers to stop should encourage safe behaviour. However, field observations have noted high rates of non-compliance at stop-controlled RLXs. To explore this further, we conducted an on-road study to identify factors that influence compliance at stop-controlled RLXs. Twenty-two drivers drove a 30...
September 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28914935/optical-parametric-generation-in-orientation-patterned-gallium-phosphide
#19
Hanyu Ye, S Chaitanya Kumar, Junxiong Wei, P G Schunemann, M Ebrahim-Zadeh
We report an optical parametric generator (OPG) based on the new nonlinear material, orientation-patterned gallium phosphide (OP-GaP). Pumped by a Q-switched nanosecond Nd:YAG laser at 1064 nm with 25 kHz pulse repetition rate, the OPG can be tuned across 1721-1850 nm in the signal and 2504-2787 nm in the idler. Using a 40-mm-long crystal in single-pass configuration, we have generated a total average output power of up to ∼18  mW, with ∼5  mW of idler power at 2670 nm, for 2 W of input pump power...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914930/continuous-wave-singly-resonant-parametric-oscillator-based-mid-infrared-optical-vortex-source
#20
A Aadhi, Varun Sharma, R P Singh, G K Samanta
We report on a high-power, continuous-wave source of optical vortices tunable in the mid-infrared (mid-IR) wavelength range. Using the orbital angular momentum (OAM) conservation of the parametric processes and the threshold conditions of the cavity modes of the singly resonant optical parametric oscillator (SRO), we have transferred the OAM of the pump beam at the near-infrared wavelength to the idler beam tunable in the mid-IR. Pumped with a vortex beam of order lp=1 at 1064 nm, the SRO, configured in a four curved mirror-based ring cavity with a 50 mm long MgO-doped periodically poled LiNbO3 crystal, produces an idler beam with an output power in excess of 2 W in a vortex spatial profile with the order li=1, tunable across 2217-3574 nm and corresponding signal beam in Gaussian intensity distribution across 1515-2046 nm...
September 15, 2017: Optics Letters
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