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https://www.readbyqxmd.com/read/28421980/guidelines-for-the-recognition-and-management-of-mixed-depression
#1
Stephen M Stahl, Debbi A Morrissette, Gianni Faedda, Maurizio Fava, Joseph F Goldberg, Paul E Keck, Yena Lee, Gin Malhi, Ciro Marangoni, Susan L McElroy, Michael Ostacher, Joshua D Rosenblat, Eva Solé, Trisha Suppes, Minoru Takeshima, Michael E Thase, Eduard Vieta, Allan Young, Mark Zimmerman, Roger S McIntyre
A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM-5 codified a new nosological entity, the "mixed features specifier," referring to individuals meeting threshold criteria for an MDE and subthreshold symptoms of (hypo)mania or to individuals with syndromal mania and subthreshold depressive symptoms. The mixed features specifier adds to a growing list of monikers that have been put forward to describe phenotypes characterized by the admixture of depressive and hypomanic symptoms (e...
February 28, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28417647/mixed-states-in-bipolar-disorder-changes-in-dsm-5-and-current-treatment-recommendations
#2
Felix Betzler, Laura Apollonia Stöver, Philipp Sterzer, Stephan Köhler
OBJECTIVE: Mixed states in affective disorders represent a particular challenge in clinical routine, characterized by a complicated course of treatment and a worse treatment response. METHODS: Clinical features of mixed states and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria are presented and critical discussed. We then performed a systematic review using the terms 'bipolar', 'mixed' and 'randomized' to evaluate current treatment options...
April 18, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28416033/pharmacological-treatment-of-mixed-states
#3
Alessandro Cuomo, Viktoriya L Nikolova, Nefize Yalin, Danilo Arnone, Andrea Fagiolini, Allan H Young
Mixed states in bipolar disorder have been neglected, and the data concerning treatment of these conditions have been relatively obscure. To address this, we systematically reviewed published pharmacological treatment data for "mixed states/episodes" in mood disorders, including "with mixed features" in DSM-5. We searched PubMed, MEDLINE, The Cochrane Library, clinicaltrials.gov, and controlled-trials.com (with different combinations of the following keywords: "mixed states/features," "bipolar," "depressive symptoms/bipolar depression," "manic symptoms," "treatment," "DSM-5") through to October 2016...
April 18, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28410054/chaotic-pattern-alternations-can-reproduce-properties-of-dominance-durations-in-multistable-perception
#4
Takashi Kanamaru
We propose a pulse neural network that exhibits chaotic pattern alternations among stored patterns as a model of multistable perception, which is reflected in phenomena such as binocular rivalry and perceptual ambiguity. When we regard the mixed state of patterns as a part of each pattern, the durations of the retrieved pattern obey unimodal distributions. We confirmed that no chaotic properties are observed in the time series of durations, consistent with the findings of previous psychological studies. Moreover, it is shown that our model also reproduces two properties of multistable perception that characterize the relationship between the contrast of inputs and the durations...
April 14, 2017: Neural Computation
https://www.readbyqxmd.com/read/28343051/tolerability-of-cariprazine-in-the-treatment-of-acute-bipolar-i-mania-a-pooled-post-hoc-analysis-of-3-phase-ii-iii-studies
#5
Willie Earley, Suresh Durgam, Kaifeng Lu, Marc Debelle, István Laszlovszky, Eduard Vieta, Lakshmi N Yatham
BACKGROUND: Atypical antipsychotics have broad-spectrum efficacy against core symptoms of acute mania/mixed states in bipolar disorder; however, they are associated with clinically significant adverse effects (AEs). METHODS: This post hoc analysis evaluated the safety and tolerability of the atypical antipsychotic cariprazine in the treatment of adult patients with acute manic/mixed episodes of bipolar I disorder. Data were taken from three 3-week randomized, double-blind, placebo-controlled, flexible-dose trials of cariprazine 3-12mg/d...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28330346/a-new-approach-to-molecular-dynamics-with-non-adiabatic-and-spin-orbit-effects-with-applications-to-qm-mm-simulations-of-thiophene-and-selenophene
#6
Marek Pederzoli, Jiří Pittner
We present surface hopping dynamics on potential energy surfaces resulting from the spin-orbit splitting, i.e., surfaces corresponding to the eigenstates of the total electronic Hamiltonian including the spin-orbit coupling. In this approach, difficulties arise because of random phases of degenerate eigenvectors and possibility of crossings of the resulting mixed states. Our implementation solves these problems and allows propagation of the coefficients both in the representation of the spin free Hamiltonian and directly in the "diagonal representation" of the mixed states...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28318547/a-symplectic-pseudospectral-method-for-nonlinear-optimal-control-problems-with-inequality-constraints
#7
Xinwei Wang, Haijun Peng, Sheng Zhang, Biaosong Chen, Wanxie Zhong
A symplectic pseudospectral method based on the dual variational principle and the quasilinearization method is proposed and is successfully applied to solve nonlinear optimal control problems with inequality constraints in this paper. Nonlinear optimal control problem is firstly converted into a series of constraint linear-quadratic optimal control problems with the help of quasilinearization techniques. Then a symplectic pseudospectral method based on dual variational principle for solving the converted constrained linear-quadratic optimal control problems is developed...
March 16, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28299935/effect-of-structural-heterogeneity-in-chemical-composition-on-online-single-particle-mass-spectrometry-analysis-of-sea-spray-aerosol-particles
#8
Camille M Sultana, Douglas B Collins, Kimberly A Prather
Knowledge of the surface composition of sea spray aerosols (SSA) is critical for understanding and predicting climate-relevant impacts. Offline microscopy and spectroscopy studies have shown that dry supermicron SSA tend to be spatially heterogeneous particles with sodium- and chloride-rich cores surrounded by organic enriched surface layers containing minor inorganic seawater components such as magnesium and calcium. At the same time, single-particle mass spectrometry reveals several different mass spectral ion patterns, suggesting that there may be a number of chemically distinct particle types...
March 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28264741/mixed-features-evolution-of-the-concept-past-and-current-definitions-and-future-prospects
#9
Alan C Swann
Mixed states address the relationships between episodes and the course of an illness, presenting significant clinical challenges. Recurrent affective disorders were described thousands of years ago as dimensional disturbances of the basic elements of behavior, combining the characteristics of what we would now consider manic and depressive episodes. It was recognized from the beginning that combinations of depressive and manic features are associated with a severe illness course, including increased suicide risk...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28264727/mixed-features-and-mixed-states-in-psychiatry-from-calculus-to-geometry
#10
Roger S McIntyre
No abstract text is available yet for this article.
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28219726/diagnostic-value-of-sleep-stage-dissociation-as-visualized-on-a-2-dimensional-sleep-state-space-in-human-narcolepsy
#11
Anders Vinther Olsen, Jens Stephansen, Eileen Leary, Paul E Peppard, Hong Sheungshul, Poul Jørgen Jennum, Helge Sorensen, Emmanuel Mignot
BACKGROUND: Type 1 narcolepsy (NT1) is characterized by symptoms believed to represent Rapid Eye Movement (REM) sleep stage dissociations, occurrences where features of wake and REM sleep are intermingled, resulting in a mixed state. We hypothesized that sleep stage dissociations can be objectively detected through the analysis of nocturnal Polysomnography (PSG) data, and that those affecting REM sleep can be used as a diagnostic feature for narcolepsy. NEW METHOD: A Linear Discriminant Analysis (LDA) model using 38 features extracted from EOG, EMG and EEG was used in control subjects to select features differentiating wake, stage N1, N2, N3 and REM sleep...
February 20, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28186814/optimum-mixed-state-discrimination-for-noisy-entanglement-enhanced-sensing
#12
Quntao Zhuang, Zheshen Zhang, Jeffrey H Shapiro
Quantum metrology utilizes nonclassical resources, such as entanglement or squeezed light, to realize sensors whose performance exceeds that afforded by classical-state systems. Environmental loss and noise, however, easily destroy nonclassical resources and, thus, nullify the performance advantages of most quantum-enhanced sensors. Quantum illumination (QI) is different. It is a robust entanglement-enhanced sensing scheme whose 6 dB performance advantage over a coherent-state sensor of the same average transmitted photon number survives the initial entanglement's eradication by loss and noise...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28184334/mixed-states-in-bipolar-disorder-etiology-pathogenesis-and-treatment
#13
REVIEW
Ather Muneer
Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states were narrowly defined in the context of bipolar I disorder, but with the advent of DSM-5 the term "mixed episode" was dropped and replaced by "mixed features" specifier which could be broadly applied to manic, hypomanic and depressive episodes in both the bipolar spectrum and major depressive disorders...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28176421/incidence-and-predictors-of-suicide-attempts-in-bipolar-i-and-ii-disorders-a-5-year-follow-up-study
#14
Sanna Pallaskorpi, Kirsi Suominen, Mikko Ketokivi, Hanna Valtonen, Petri Arvilommi, Outi Mantere, Sami Leppämäki, Erkki Isometsä
OBJECTIVES: Few long-term studies on bipolar disorder (BD) have investigated the incidence and risk factors of suicide attempts (SAs) specifically related to illness phases. We examined the incidence of SAs during different phases of BD in a long-term prospective cohort of bipolar I (BD-I) and bipolar II (BD-II) patients, and risk factors specifically for SAs during major depressive episodes (MDEs). METHODS: In the Jorvi Bipolar Study (JoBS), 191 BD-I and BD-II patients were followed using life-chart methodology...
February 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28155205/a-pilot-study-to-determine-whether-combinations-of-objectively-measured-activity-parameters-can-be-used-to-differentiate-between-mixed-states-mania-and-bipolar-depression
#15
Jan Scott, Arne E Vaaler, Ole Bernt Fasmer, Gunnar Morken, Karoline Krane-Gartiser
BACKGROUND: Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies that assessed activity parameters reported only mean levels rather than complexity or predictability of activity. We identified cases presenting in one of three acute phases of bipolar disorder and examined whether the application of non-linear dynamic models to the description of objectively measured activity can be used to predict case classification...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28145467/exploration-quantum-steering-nonlocality-and-entanglement-of-two-qubit-x-state-in-structured-reservoirs
#16
Wen-Yang Sun, Dong Wang, Jia-Dong Shi, Liu Ye
In this work, there are two parties, Alice on Earth and Bob on the satellite, which initially share an entangled state, and some open problems, which emerge during quantum steering that Alice remotely steers Bob, are investigated. Our analytical results indicate that all entangled pure states and maximally entangled evolution states (EESs) are steerable, and not every entangled evolution state is steerable and some steerable states are only locally correlated. Besides, quantum steering from Alice to Bob experiences a "sudden death" with increasing decoherence strength...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144880/use-of-stimulants-in-bipolar-disorder
#17
REVIEW
Giulio Perugi, Giulia Vannucchi, Fulvio Bedani, Ettore Favaretto
Several international guidelines indicate stimulants, including methylphenidate (MPH), amphetamines and derivatives, modafinil, and armodafinil among the second-third-line choices for bipolar depression. Efficacy of stimulants has been also reported for the management of residual depressive symptoms such as fatigue and sleepiness and for the management of affective, cognitive, and behavioral symptoms in children and adult bipolar patients with comorbid ADHD. Few case reports show positive results with MPH in the treatment of resistant mania...
January 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28128592/directly-measuring-the-degree-of-quantum-coherence-using-interference-fringes
#18
Yi-Tao Wang, Jian-Shun Tang, Zhi-Yuan Wei, Shang Yu, Zhi-Jin Ke, Xiao-Ye Xu, Chuan-Feng Li, Guang-Can Guo
Quantum coherence is the most distinguished feature of quantum mechanics. It lies at the heart of the quantum-information technologies as the fundamental resource and is also related to other quantum resources, including entanglement. It plays a critical role in various fields, even in biology. Nevertheless, the rigorous and systematic resource-theoretic framework of coherence has just been developed recently, and several coherence measures are proposed. Experimentally, the usual method to measure coherence is to perform state tomography and use mathematical expressions...
January 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28113920/predicting-mood-changes-in-bipolar-disorder-through-heartbeat-nonlinear-dynamics
#19
Gaetano Valenza, Mimma Nardelli, Antonio Lanata', Claudio Gentili, Gilles Bertschy, Markus Kosel, Enzo Pasquale Scilingo
Bipolar Disorder (BD) is characterized by an alternation of mood states from depression to (hypo)mania. Mixed states, i.e., a combination of depression and mania symptoms at the same time, can also be present. The diagnosis of this disorder in the current clinical practice is based only on subjective interviews and questionnaires, while no reliable objective psychophysiological markers are available. Furthermore, there are no biological markers predicting BD outcomes, or providing information about the future clinical course of the phenomenon...
April 20, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28077190/measures-of-the-dsm-5-mixed-features-specifier-of-major-depressive-disorder
#20
Mark Zimmerman
During the past two decades, a number of studies have found that depressed patients frequently have manic symptoms intermixed with depressive symptoms. While the frequency of mixed syndromes are more common in bipolar than in unipolar depressives, mixed states are also common in patients with major depressive disorder. The admixture of symptoms may be evident when depressed patients present for treatment, or they may emerge during ongoing treatment. In some patients, treatment with antidepressant medication might precipitate the emergence of mixed states...
January 12, 2017: CNS Spectrums
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