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https://www.readbyqxmd.com/read/27904076/amorphous-amorphous-phase-separation-of-freeze-concentrated-protein-and-amino-acid-excipients-for-lyophilized-formulations
#1
Ken-Ichi Izutsu, Hiroyuki Yoshida, Hiroko Shibata, Yukihiro Goda
The objective of this study was to elucidate the mixing state of proteins and amino acid excipients concentrated in the amorphous non-ice region of frozen solutions. Thermal analysis of frozen aqueous solutions was performed in heating scans before and after a heat treatment. Frozen aqueous solutions containing a protein (e.g., recombinant human albumin, gelatin) or a polysaccharide (dextran) and an amino acid excipient (e.g., L-arginine, L-arginine hydrochloride, L-arginine monophosphate, sodium L-glutamate) at varied mass ratios showed single or double Tg' (glass transition temperature of maximally freeze-concentrated solutes)...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27901119/how-does-the-spin-state-of-co-ions-affect-the-insulator-metal-transition-in-bi2a2co2o8-a%C3%A2-%C3%A2-ca-sr-ba
#2
Xiaokun Huang, Weiyi Zhang
The misfit layered Bi2A2Co2O8 (A = Ca, Sr, Ba) compounds experience an insulator to metal transition as A's ionic radius increases. This feature is contradictory to the conventional wisdom that larger lattice constant favors insulating rather than metallic state, and is also difficult to be reconciled using the Anderson weak localization theory. In this paper, we show from the first-principles calculation that an insulator-metal transition takes place from a nonmagnetic low-spin state of Co(3+) ions to a hexagonally arranged intermediate-spin low-spin mixed-state in CoO2 plane when ionic radius increases from Ca to Ba...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27883083/refractive-index-and-absorption-attribution-of-highly-absorbing-brown-carbon-aerosols-from-an-urban-indian-city-kanpur
#3
P M Shamjad, S N Tripathi, Navaneeth M Thamban, Heidi Vreeland
Atmospheric aerosols influence Earth's radiative balance, having both warming and cooling effects. Though many aerosols reflect radiation, carbonaceous aerosols such as black carbon and certain organic carbon species known as brown carbon have the potential to warm the atmosphere by absorbing light. Black carbon absorbs light over the entire solar spectrum whereas brown carbon absorbs near-UV wavelengths and, to a lesser extent, visible light. In developing countries, such as India, where combustion sources are prolific, the influence of brown carbon on absorption may be significant...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869049/exclusion-of-overlapping-symptoms-in-dsm-5-mixed-features-specifier-heuristic-diagnostic-and-treatment-implications
#4
Gin S Malhi, Yulisha Byrow, Tim Outhred, Kristina Fritz
This article focuses on the controversial decision to exclude the overlapping symptoms of distractibility, irritability, and psychomotor agitation (DIP) with the introduction of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) mixed features specifier. In order to understand the placement of mixed states within the current classification system, we first review the evolution of mixed states. Then, using Kraepelin's original classification of mixed states, we compare and contrast his conceptualization with modern day definitions...
November 21, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27866502/dysphoric-mania-mixed-states-and-mania-with-mixed-features-specifier-are-we-mixing-things-up
#5
Susan L McElroy, Paul E Keck
Various terms have been used to describe mania when it is accompanied by depressive symptoms. In this article, we attempt to define and discuss 3 of these terms: dysphoric mania, mixed state, and mania with mixed features specifier. We conclude that whatever term is used, it is important to be aware that mania is more often unpleasant than pleasant, and that the unpleasantness is not limited to depression.
November 21, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27858444/quantifying-entanglement-of-maximal-dimension-in-bipartite-mixed-states
#6
Gael Sentís, Christopher Eltschka, Otfried Gühne, Marcus Huber, Jens Siewert
The Schmidt coefficients capture all entanglement properties of a pure bipartite state and therefore determine its usefulness for quantum information processing. While the quantification of the corresponding properties in mixed states is important both from a theoretical and a practical point of view, it is considerably more difficult, and methods beyond estimates for the concurrence are elusive. In particular this holds for a quantitative assessment of the most valuable resource, the forms of entanglement that can only exist in high-dimensional systems...
November 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27831463/what-is-the-role-of-conventional-antidepressants-in-the-treatment-of-major-depressive-episodes-with-mixed-features-specifier
#7
Gianni L Faedda, Ciro Marangoni
The newly introduced Mixed Features Specifier of Major Depressive Episode and Disorder (MDE/MDD) is especially challenging in terms of pharmacological management. Prior to the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of the mixed features specifier were intradepressive hypomanic symptoms, always and only associated with bipolar disorder (BD). Intradepressive hypomanic symptoms, mostly referred to as depressive mixed states (DMX), have been poorly characterized, and their treatment offers significant challenges...
November 10, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27780355/the-development-of-visible-wavelength-maldi-cell-mass-spectrometry-cms-for-high-efficiency-single-cell-analysis
#8
Caiqiao Xiong, Xiaoyu Zhou, Qing He, Xi Huang, Jiyun Wang, Wen-Ping Peng, Huan-Cheng Chang, Zongxiu Nie
Mass is a fundamental physical property of individual cell, from which reveals the cell growth, cycle, and activity. Taking advantage of the cell mass spectrometry (CMS), accurate mass measurement of charged single cell has been achieved. However, with the increasing demand for high-efficiency single-cell analysis in biology, the limited throughput and inefficient cell desorption/ionization of the CMS inevitably becomes an important issue. To address the challenge, a state of the art visible-wavelength matrix assisted laser desorption/ionization (MALDI) CMS was developed...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27758708/the-role-of-electroconvulsive-therapy-ect-in-bipolar-disorder-effectiveness-in-522-patients-with-bipolar-depression-mixed-state-mania-and-catatonic-features
#9
Giulio Perugi, Pierpaolo Medda, Cristina Toni, Michela Giorgi Mariani, Chiara Socci, Mauro Mauri
We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. <p> Method: 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features. <p> Results: Of the original sample only 22 patients were excluded for the occurrence of side effects or consent withdrawal...
October 17, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27740786/experimental-test-of-residual-error-disturbance-uncertainty-relations-for-mixed-spin-%C3%A2-states
#10
Bülent Demirel, Stephan Sponar, Georg Sulyok, Masanao Ozawa, Yuji Hasegawa
The indeterminacy inherent in quantum measurements is an outstanding character of quantum theory, which manifests itself typically in the uncertainty principle. In the last decade, several universally valid forms of error-disturbance uncertainty relations were derived for completely general quantum measurements for arbitrary states. Subsequently, Branciard established a form that is optimal for spin measurements for some pure states. However, the bound in his inequality is not stringent for mixed states. One of the present authors recently derived a new bound tight in the corresponding mixed state case...
September 30, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27739757/comparing-classical-and-quantum-equilibration
#11
Artur S L Malabarba, Terry Farrelly, Anthony J Short
By using a physically relevant and theory independent definition of measurement-based equilibration, we show quantitatively that equilibration is easier for quantum systems than for classical systems, in the situation where the initial state of the system is completely known (a pure state). This shows that quantum equilibration is a fundamental aspect of many quantum systems, while classical equilibration relies on experimental ignorance. When the state is not completely known (a mixed state), this framework also shows that quantum equilibration requires weaker conditions...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27715136/quantum-correlations-separability-and-quantum-coherence-length-in-equilibrium-many-body-systems
#12
Daniele Malpetti, Tommaso Roscilde
Nonlocality is a fundamental trait of quantum many-body systems, both at the level of pure states, as well as at the level of mixed states. Because of nonlocality, mixed states of any two subsystems are correlated in a stronger way than what can be accounted for by considering the correlated probabilities of occupying some microstates. In the case of equilibrium mixed states, we explicitly build two-point quantum correlation functions, which capture the specific, superior correlations of quantum systems at finite temperature, and which are directly accessible to experiments when correlating measurable properties...
September 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27708572/drifting-states-and-synchronization-induced-chaos-in-autonomous-networks-of-excitable-neurons
#13
Rodrigo Echeveste, Claudius Gros
The study of balanced networks of excitatory and inhibitory neurons has led to several open questions. On the one hand it is yet unclear whether the asynchronous state observed in the brain is autonomously generated, or if it results from the interplay between external drivings and internal dynamics. It is also not known, which kind of network variabilities will lead to irregular spiking and which to synchronous firing states. Here we show how isolated networks of purely excitatory neurons generically show asynchronous firing whenever a minimal level of structural variability is present together with a refractory period...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27689255/direct-measurement-of-the-density-matrix-of-a-quantum-system
#14
G S Thekkadath, L Giner, Y Chalich, M J Horton, J Banker, J S Lundeen
One drawback of conventional quantum state tomography is that it does not readily provide access to single density matrix elements since it requires a global reconstruction. Here, we experimentally demonstrate a scheme that can be used to directly measure individual density matrix elements of general quantum states. The scheme relies on measuring a sequence of three observables, each complementary to the last. The first two measurements are made weak to minimize the disturbance they cause to the state, while the final measurement is strong...
September 16, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27663797/an-approach-to-treat-bipolar-disorders-mixed-states
#15
Giuseppe Tavormina
Very often clinicians meet great difficulties in making a correct diagnosis of mood disorders which they are assessing, above all when mixed states are present: this because the patients mainly focus on their own symptoms of depressive uneasiness; mixed symptoms can insidiously infiltrate into the mood and life of the patients causing a chronic and worsening clinical state. It is essential not to forget that the depression is only one phase of a broader bipolar mood disorder, and this has to be the illness to be treated by psychiatrists and, generally, by clinicians managing an appropriate polytherapy with mood-stabilisers and antidepressants...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27618746/treatment-of-mixed-features-in-bipolar-disorder
#16
Joshua D Rosenblat, Roger S McIntyre
Mood episodes with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-defined mixed features are highly prevalent in bipolar disorder (BD), affecting ~40% of patients during the course of illness. Mixed states are associated with poorer clinical outcomes, greater treatment resistance, higher rates of comorbidity, more frequent mood episodes, and increased rates of suicide. The objectives of the current review are to identify, summarize, and synthesize studies assessing the efficacy of treatments specifically for BD I and II mood episodes (ie, including manic, hypomanic, and major depressive episodes) with DSM-5-defined mixed features...
September 13, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27607977/two-photon-tomography-using-on-chip-quantum-walks
#17
James G Titchener, Alexander S Solntsev, Andrey A Sukhorukov
We present an approach to quantum tomography based on first expanding a quantum state across extra degrees of freedom and then exploiting the introduced sparsity to perform reconstruction. We formulate its application to photonic circuits and show that measured spatial photon correlations at the output of a specially tailored discrete-continuous quantum walk can enable full reconstruction of any two-photon spatially entangled and mixed state at the input. This approach does not require any tunable elements, so it is well suited for integration with on-chip superconducting photon detectors...
September 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27607359/affective-temperaments-and-emotional-traits-are-associated-with-a-positive-screening-for-premenstrual-dysphoric-disorder
#18
Rachel A Câmara, Cristiano A Köhler, Michael Maes, Paulo R Nunes-Neto, André R Brunoni, João Quevedo, Brisa S Fernandes, Giulio Perugi, Thomas N Hyphantis, André F Carvalho
OBJECTIVES: Preliminary evidence indicates that premenstrual dysphoric disorder (PMDD) may be frequently co-morbid with bipolar spectrum disorders. In addition, the manifestations of PMDD seem similar to a subthreshold depressive mixed state. Nevertheless, the associations between PMDD and affective temperaments and emotional traits have not been previously investigated. METHODS: A consecutive sample of 514 drug-free Brazilian women (mean age: 22.8; SD=5.4years) took part in this cross-sectional study...
August 18, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27599057/characterization-mixing-state-and-evolution-of-urban-single-particles-in-xi-an-china-during-wintertime-haze-days
#19
Yang Chen, Junji Cao, Rujin Huang, Fumo Yang, Qiyuan Wang, Yichen Wang
A Single Particle Aerosol Mass Spectrometer (SPAMS) was deployed in the urban area of Xi'an to investigate size-resolved chemical composition and mixing state of single particles during the heavy haze episode occurred from January 13 to January 27 in 2013. Nine major single particle types were resolved with ART-2a algorithm including biomass burning (BB), Potassium-Secondary (KSec), elemental and organic Carbon (ECOC), sodium-potassium-rich ECOC (NaKECOC), sodium-potassium-rich-secondary (NaKSec), EC, OC, and Dust...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27559486/effectiveness-of-simple-individual-psychoeducation-for-bipolar-ii-disorder
#20
Yuka Saito-Tanji, Emi Tsujimoto, Reiko Taketani, Ami Yamamoto, Hisae Ono
Several studies have proven the effectiveness of psychoeducation in bipolar II disorder patients; however, simpler psychoeducation is needed in daily medical practice. Therefore, we devised a simple individual psychoeducation program, which involved 20-minute sessions spent reading a textbook aloud in the waiting time before examination. Here, we report a successful case of simple individual psychoeducation with a patient with bipolar II disorder, a 64-year-old woman who had misconceptions surrounding her mood due to 24 years of treatment for depression...
2016: Case Reports in Psychiatry
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