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Enric Contreras, Javier de la Rubia, Julio Del Río-Garma, Maribel Díaz-Ricart, José María García-Gala, Miguel Lozano
Thrombotic microangiopathies (TMA) are disorders defined by the presence of a microangiopathic hemolytic anemia (with the characteristic hallmark of schistocytes in the peripheral blood smear), thrombocytopenia and organ malfunction of variable intensity. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are the most important forms of TMA and, without the adequate treatment, they are associated with high morbimortality. In recent years, significant advances in the knowledge of the pathophysiology of TMA have occurred...
April 8, 2015: Medicina Clínica
, Stefano Passalacqua, Pietro Manuel Ferraro
We review the available literature on granulocyte-monocyte apheresis for the treatment of inflammatory bowel disease and report the outcome data of a multicenter observational study from the Italian registry for therapeutic apheresis.
January 2012: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Javier de la Rubia, Federico Moscardó, María J Gómez, Ramón Guardia, Pilar Rodríguez, Ana Sebrango, Concepción Zamora, Guillermo Debén, Rosa Goterris, Rafaela López, Francisco Peña, Misericordia Pujol, Antonio Vidaller, Julio Del Río-Garma, Miguel A Sanz
BACKGROUND: Between 30% and 60% of patients with thrombotic thrombocytopenic purpura (TTP) relapse and mortality remains at 15-20%. Limited clinical data suggest that the administration of anti-CD20 antibody (rituximab) may be useful in preventing acute refractory and chronic relapsing TTP. DESIGN AND METHODS: We studied the clinical response to rituximab in 24 adult patients (median age 42 years, range 24-72 years) from 15 Spanish centers with an acute refractory (14 patients) or acute relapsing (10 patients) episode of idiopathic TTP...
December 2010: Transfusion and Apheresis Science
J del Río-Garma, A Pereira, J L Arroyo, J Mateo, A Alvarez-Larrán, C Martínez, J Muncunill, L Barbolla
BACKGROUND AND OBJECTIVES: Methylene blue photo-inactivated plasma (MBPIP) has been reported to be less effective than fresh-frozen plasma (FFP) in the treatment of thrombotic thrombocytopenic purpura, which suggests a reduced content of the von Willebrand factor metalloprotease ADAMTS-13 in MBPIP. MATERIALS AND METHODS: ADAMTS-13 activity and von Willebrand factor antigen (vWF:Ag) levels were measured in plasma before and after photo-oxidation by either the Springe method or a commercial 'in house' system as well as in cryoprecipitate-poor plasma (CPP) and FFP (20 units each)...
August 2008: Vox Sanguinis
M N Holten-Andersen, N Brunner, I J Christensen, V Jensen, H J Nielsen
Blood transfusion during surgery for solid tumors may reduce patient survival because of various bioactive substances present in blood preparations. The anti-proteolytic protein tissue inhibitor of metalloproteinases-1 (TIMP-1) present in large quantities in platelets has been shown to stimulate cell growth and to inhibit apoptosis and may therefore be considered to influence tumor progression. We measured TIMP-1 levels in blood transfusion preparations. especially in platelet-containing preparations, before and after leucofiltration and at different time-points during storage...
2002: Scandinavian Journal of Clinical and Laboratory Investigation
A D'Amato, G Nigri, A Pronio, C Montesani, G Ferrazza, A Rusignolo, S Solinas, G Ribotta
Authors expose their experience with autotransfusion, made during several years in a general surgery university department. Discussion is made about ethic and economical aspect of the philosophy guiding the most general concept of blood sparing, and different methods of autotransfusion; attention is then focused on practical experience made during two years (1995-1997) when the program worked well. On the whole, in 94 patients, 172 blood units were collected plus 10 plasma units obtained by aferesis. No method-related complications are have been observed...
November 2000: Annali Italiani di Chirurgia
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