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https://www.readbyqxmd.com/read/29319362/do-anti-epileptic-drugs-increase-suicide-in-epilepsy-10-years-after-the-fda-alert
#1
Marco Mula
No abstract text is available yet for this article.
January 10, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29317303/herbal-medicine-uses-to-treat-people-with-epilepsy-a-survey-in-rural-communities-of-northern-peru
#2
Auditeau Emilie, Moyano Luz Maria, Bourdy Geneviève, Nizard Mandy, Jost Jérémy, Ratsimbazafy Voa, Preux Pierre-Marie, Boumediene Farid
ETHNOPHARMACOLOGICAL RELEVANCE: Epilepsy affects 150,000 people in Peru, with a prevalence of 16.6/1,000 and a treatment gap of 75%. Herbal medicine (HM) is widely used in this country. AIM OF THE STUDY: We aimed to assess the use of plants in a rural community in northern Peru as part of therapeutic strategies for people with epilepsy (PWE). MATERIALS AND METHODS: The study was a cross-sectional observational and descriptive study. The inclusion criteria for people with epilepsy were 2 years of age and over, having lived in the study area for at least 3 months and a confirmed diagnosis of epilepsy by a neurologist...
January 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29317153/should-patients-with-complex-febrile-seizure-be-admitted-for-further-management
#3
Heather Olson, Tiffany Rudloe, Tobias Loddenkemper, Marvin B Harper, Amir A Kimia
BACKGROUND AND AIMS: Children with first complex febrile seizure (CFS) are often admitted for observation. The goals of this study were 1) to assess the risk of seizure recurrence during admission, 2) to determine whether early EEG affects acute management. DESIGN/METHODS: We retrospectively reviewed a cohort of children 6-60months of age admitted from a Pediatric Emergency Department for first CFS over a 15year period. We excluded children admitted for supportive care of their febrile illness...
December 28, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29314463/prevalence-and-patterns-of-anti-epileptic-medication-prescribing-in-the-treatment-of-epilepsy-in-older-adults-with-intellectual-disabilities
#4
M O'Dwyer, J Peklar, N Mulryan, P McCallion, M McCarron, M C Henman
BACKGROUND: The prevalence of epilepsy is higher in people with intellectual disability (ID) and increases with the degree of ID. Although life expectancy for people with ID is increasing, people with ID coexisting with epilepsy have a higher mortality rate, particularly those who had recent seizures. There have been few observational studies of the prevalence and patterns of anti-epileptic prescribing among older people with ID and epilepsy. The aim of this study was to investigate prevalence and patterns of anti-epileptic prescribing in the treatment of epilepsy in a representative population of older people with ID and epilepsy...
January 5, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29306976/deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-drug-resistant-epilepsy
#5
REVIEW
Tim A M Bouwens van der Vlis, Olaf E M G Schijns, Frédéric L W V J Schaper, Govert Hoogland, Pieter Kubben, Louis Wagner, Rob Rouhl, Yasin Temel, Linda Ackermans
Despite the use of first-choice anti-epileptic drugs and satisfactory seizure outcome rates after resective epilepsy surgery, a considerable percentage of patients do not become seizure free. ANT-DBS may provide for an alternative treatment option in these patients. This literature review discusses the rationale, mechanism of action, clinical efficacy, safety, and tolerability of ANT-DBS in drug-resistant epilepsy patients. A review using systematic methods of the available literature was performed using relevant databases including Medline, Embase, and the Cochrane Library pertaining to the different aspects ANT-DBS...
January 6, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29305866/novel-and-rapid-osteoporosis-model-established-in-zebrafish-using-high-iron-stress
#6
Wenjuan Zhang, Jingjin Xu, Juhui Qiu, Cencan Xing, Xiumin Li, Bo Leng, Yi Su, Jinmei Lin, Jiaofen Lin, Xuqiao Mei, Yiqun Huang, Anming Meng, Yutian Pan, Yu Xue
Osteoporosis is a global public health concern and, it can result from numerous pathogenic mechanisms, many of which are closely related with age, nutritional disorders, endocrine imbalance, or adverse drug side effects presented by glucocorticoids, heparin, and anti-epileptics. Given its wide range etiologies, it is crucial to establish an animal model of osteoporosis for use in screening potential drugs quickly and effectively. Previous research has reported that an accumulation of elevated iron in the body is an independent risk factor for osteoporosis...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29301936/mapping-two-neurosteroid-modulatory-sites-in-the-prototypic-pentameric-ligand-gated-ion-channel-glic
#7
Wayland W L Cheng, Zi-Wei Chen, John R Bracamontes, Melissa M Budelier, Kathiresan Krishnan, Daniel J Shin, Cunde Wang, Xin Jiang, Douglas F Covey, Gustav Akk, Alex S Evers
Neurosteroids are endogenous sterols that potentiate or inhibit pentameric ligand gated ion channels (pLGICs), and can be effective anesthetics, analgesics, or anti-epileptic drugs. The complex effects of neurosteroids on pLGICs suggest the presence of multiple binding sites in these receptors. Here, using a series of novel neurosteroid photolabeling reagents combined with top-down and middle-down mass spectrometry, we have determined the stoichiometry, sites and orientation of binding for 3α,5α-pregnane neurosteroids in the Gloeobacter ligand gated ion channel (GLIC), a prototypic pLGIC,...
January 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29289807/seizures-in-surgically-resected-atypical-and-malignant-meningiomas-long-term-outcome-analysis
#8
Yu-Chi Wang, Chi-Cheng Chuang, Po-Hsun Tu, Kuo-Chen Wei, Chieh-Tsai Wu, Cheng-Chi Lee, Zhuo-Hao Liu, Pin-Yuan Chen
PURPOSE: Seizures in rare atypical and malignant meningiomas were significantly under-studied. Our aim was to examine the rates, predictors, and seizure control in these meningiomas, and to analyze associations between clinical characteristics and seizure free survival (SFS) following surgical resection in an Asian population. METHODS: We retrospectively analyzed 102 patients with atypical or malignant meningiomas. Seizures occurring before and after the operation were reviewed...
December 17, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29289531/epileptic-seizures-are-reduced-by-autonomic-biofeedback-therapy-through-enhancement-of-fronto-limbic-connectivity-a-controlled-trial-and-neuroimaging-study
#9
Yoko Nagai, Julia Aram, Matthias Koepp, Louis Lemieux, Marco Mula, Hugo Critchley, Sanjay Sisodiya, Mara Cercignani
BACKGROUND: Thirty-percent of patients with epilepsy are drug-resistant, and might benefit from effective noninvasive therapeutic interventions. Evidence is accumulating on the efficacy of autonomic biofeedback therapy using galvanic skin response (GSR; an index of sympathetic arousal) in treating epileptic seizures. This study aimed to extend previous controlled clinical trials of autonomic biofeedback therapy with a larger homogeneous sample of patients with temporal lobe epilepsy. In addition, we used neuroimaging to characterize neural mechanisms of change in seizure frequency following the therapy...
December 13, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29276875/drug-reaction-with-eosinophilia-and-systemic-symptoms-in-a-child-on-multiple-antiepileptics
#10
Jyotindra Narayan Goswami, Pankaj C Vaidya, Arushi Gahlot Saini, Dipankar De, Bishan Dass Radotra, Pratibha D Singhi
Goswami JN, Vaidya PC, Saini AG, De D, Radotra BD, Singhi PD. Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics. Turk J Pediatr 2017; 59: 197-199. Drug reaction with eosinophilia and systemic symptoms (DRESS) is an adverse drug-reaction that may mimic systemic illnesses and have a fulminant presentation. We describe an 8-year-old girl with epilepsy and exposure to multiple anti-epileptics who presented with fever, extensive maculopapular rash, cervical lymphadenopathy, hepatomegaly, progressive anemia and transaminitis...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29260458/the-risk-of-thrombocytopenia-during-valproic-acid-therapy-a-critical-summary-of-available-clinical-data
#11
Massimiliano Buoli, Marta Serati, Andrea Botturi, A Carlo Altamura
Valproate is an effective anti-epileptic and mood stabilizer drug, but its prescription may be complicated by the development of thrombocytopenia. The purpose of the present manuscript is to provide a critical overview about the risk of thrombocytopenia during treatment with valproate. A search of the main database sources has been conducted to identify relevant papers about the topic. In the studies with a larger sample size (> 150 subjects), thrombocytopenia occurred in 12-18% of subjects receiving treatment with valproate...
December 19, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/29225530/two-targets-are-better-than-one-a-new-strategy-to-increase-the-specificity-of-anti-epileptic-drugs
#12
COMMENT
Matthew C Weston
No abstract text is available yet for this article.
July 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/29223050/a-simple-rapid-and-stability-indicating-validated-method-for-quantification-of-lamotrigine-in-human-plasma-and-dry-plasma-spot-using-lc-esi-ms-ms-application-in-clinical-study
#13
Kuldeep Kumar Namdev, Jaya Dwivedi, Deepak Chandra Chilkoti, Swapnil Sharma
Lamotrigine (LTZ) is a phenyltriazine derivative which belongs to anti-epileptic drugs (AEDs) class and prescribed as mono- or adjunctive-therapy in treatment of epilepsy. Therapeutic drug monitoring (TDM) of AEDs provides a valid clinical tool in optimization of overall therapy. However, TDM is challenging due to the high biological samples (plasma/blood) storage/shipment costs and the limited availability of laboratories providing TDM services. Sampling in the form of dry plasma spot (DPS) or dry blood spot (DBS) are suitable alternative to overcome these issues...
December 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29212069/cellular-effects-of-the-antiepileptic-drug-valproic-acid-in-glioblastoma
#14
Marita Eckert, Lukas Klumpp, Stephan Huber
BACKGROUND/AIMS: Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug is used to treat epileptic seizure of glioblastoma patients. Besides its antiepileptic activity, VPA has been attributed further functions that improve the clinical outcome of glioblastoma patients. Those comprise the inhibition of some histone deacetylase (HDAC) isoforms which reportedly may result in radiosensitization. Retrospective analysis of patient data, however, could not unequivocally confirm a prolonged survival of glioblastoma patients receiving VPA...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29209390/the-mechanism-of-anti-epileptogenesis-by-levetiracetam-treatment-is-similar-to-the-spontaneous-recovery-of-idiopathic-generalized-epilepsy-during-adolescence
#15
Hiroki Kikuyama, Tadahito Hanaoka, Tetsufumi Kanazawa, Yasushi Yoshida, Takafumi Mizuno, Hirotaka Toyoda, Hiroshi Yoneda
Objective: The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation of the neural network occurs, spontaneous seizures or epileptogenesis develops. This study investigated whether the anti-epileptogenic effect of levetiracetam is due to its alternate apoptotic activity...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29208197/-treatment-of-rolandic-epilepsy
#16
Maria Jose Miranda, Banoo Bakir Ahmad
Recent literature indicates, that rolandic epilepsy/epilepsy of childhood with centrotemporal spikes may not be as benign as previously assumed. This study investigates the existing evidence, which describes the treatment effects on seizure frequency as well as improvement of cognition in children with rolandic epilepsy. We conclude, that treatment with anti-epileptic drugs could be justified, if treatment reduces seizures, prevents the evolution to atypical forms, or diminishes the negative cognitive consequences associated with the disease...
November 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29207692/oxidative-stress-in-the-development-of-genetic-generalised-epilepsy-an-observational-study-in-southern-indian-population
#17
D K V Prasad, U Satyanarayana, Uzma Shaheen, T Surya Prabha, Anjana Munshi
Introduction: Oxidative stress resulting from excessive generation of Reactive Oxygen Species (ROS) plays a significant role in neurodegeneration associated with seizures/epilepsy. Aim: To evaluate oxidative stress markers and antioxidant enzymes in Genetic Generalised Epilepsy (GGE) and to know the extent of oxidative stress induced by Anti-Epileptic Drugs (AEDs) with the time duration of treatment. Materials and Methods: In this case-control study, 310 GGE patients (male:female=203:107), who were on AED treatment (n=235) and 75 untreated patients (male:female=49:26) along with 310 age and sex matched healthy controls were recruited...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202377/quantifying-the-prognostic-significance-in-glioblastoma-of-seizure-history-at-initial-presentation-a-systematic-review-and-meta-analysis
#18
REVIEW
Victor M Lu, Toni R Jue, Kevin Phan, Kerrie L McDonald
The role of prognostic factors in the management of glioblastoma (GBM) is very important given the stasis in improving its clinical outcomes. Patients who initially present with a positive seizure history at diagnosis have anecdotally experienced superior survival outcomes. The aim of this review was to perform a systematic review and meta-analysis to quantify the potential prognostic significance of positive seizure history in GBM patients. A search strategy was performed using the PRISMA guidelines for article identification, screening, eligibility and inclusion...
December 1, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29201120/long-term-video-eeg-monitoring-findings-in-children-and-adolescents-with-intractable-epilepsy
#19
Yasaman Ghazavi, Ebrahim Asayesh Zarchi, Taher Taheri, Mahdi Safiabadi, Elham Rahimian, Susan Amirsalari
Objective: Long Term Video-EEG Monitoring (LTM) may give us important information in the preoperative assessment of these patients. We performed this study for the first time in pediatric age group in Iran. Materials and Methods: In this cross-sectional study, 43 children between 4 to 18 yr, with intractable epilepsy referred to Shefa Neuroscience Research Center, Tehran, Iranfrom2007-2012, were enrolled to study in order to evaluate their long-term video EEG findings...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29198411/epileptic-spasms-secondary-to-acute-cerebral-and-cerebellar-encephalitis
#20
Tohru Okanishi, Ayataka Fujimoto, Risa Hashimoto, Mitsuyo Nishimura, Sotaro Kanai, Miho Ogawa, Takayuki Suzuki, Hirotaka Motoi, Yukitoshi Takahashi, Hideo Enoki
BACKGROUND: Patients with infection-related acute encephalitis sometimes develop epilepsy in the chronic phase of the disease. Patients with postencephalitic epilepsy usually develop partial seizures due to the lesions generated by the encephalitis. We report a case who developed late-onset epileptic spasms after acute cerebral and cerebellar encephalitis. CASE REPORT: A 5-year-old girl showed severe tremor, gait ataxia, partial or generalized tonic-clonic seizures, hyperactivity, and panic attacks after a mild enterocolitis...
November 29, 2017: Brain & Development
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