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JOURNAL ARTICLE
Line Kessel, Hanne Jensen, Ann-Cathrine Larsen, Thomas Rosenberg, Kamilla Rothe Nissen
PURPOSE: The aim of the study was to describe the temporal changes in causes and prevalence of childhood visual impairment in Denmark based on the National Danish Registry of Children with Visual Impairment (NDRCVI). METHODS: Annual reports on the NDRCVI since its establishment in 1979 were reviewed and data on the number of registered children and the causes for registration with a visual impairment were evaluated. RESULTS: The average annual incidence of childhood visual impairment in Denmark is 2...
April 25, 2024: Acta Ophthalmologica
#2
REVIEW
Luis F Andrade, Parsa Abdi, Kayla D Mashoudy, Amritpal Kooner, Ashley Egler, Rebecca Urbonas, Aaron Smith, Gil Yosipovitch
Patient education in atopic dermatitis (AD) has worked in parallel to the gold standard of pharmacological treatment as a foundational component of therapeutic regimens. In addition to improving patient education, past investigations of educational interventions have demonstrated profound reductions in disease severity for patients living with AD. However, prior meta-analytical work has focused mostly on comparing in-person interventions, and thus the need to determine the effectiveness of virtual methodologies in the current post-COVID era remains...
April 25, 2024: Archives of Dermatological Research
#3
JOURNAL ARTICLE
Yankun Song, Shangbin Li, Ling Hao, Yiwei Han, Wenhui Wu, Yuqing Fan, Xiong Gao, Xueying Li, Changjun Ren, Yuan Chen
UNLABELLED: Given the persistent ambiguity regarding the etiology of neonatal stroke across diverse origins, our objective was to conduct a comprehensive evaluation of both qualitative and quantitative risk factors. An exhaustive search of eight databases was executed to amass all pertinent observational studies concerning risk factors for neonatal stroke from various origins. Subsequent to independent screening, data extraction, and bias assessment by two researchers, a meta-analysis was conducted utilizing RevMan and Stata software...
April 25, 2024: European Journal of Pediatrics
#4
JOURNAL ARTICLE
Elliot H Choi, John D Hong, Susie Suh, Carolline Rodrigues Menezes, Kimberly R Walker, Joseph Bui, Annabelle Storch, Diana Torres, Jennifer Espinoza, Kourosh Shahraki, Iliana Molina, Donny W Suh
PURPOSE: To analyze referral rates, patient demographics, referral indications, and the impact of socioeconomic factors on ocular health from the University of California Irvine (UCI) Eye Mobile for Children, particularly during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: A retrospective chart review was performed on de-identified records of children examined on the UCI Eye Mobile. GraphPad Prism 10.0.0 and Python software were used for statistical analyses...
April 25, 2024: Journal of Pediatric Ophthalmology and Strabismus
#5
REVIEW
Marjolein van der Linden, Esther S Veldhoen, Emad Arasteh, Xi Long, Thomas Alderliesten, Robbin de Goederen, Jeroen Dudink
Pediatric sleep-related breathing disorders, or sleep-disordered breathing (SDB), cover a range of conditions, including obstructive sleep apnea, central sleep apnea, sleep-related hypoventilation disorders, and sleep-related hypoxemia disorder. Pediatric SDB is often underdiagnosed, potentially due to difficulties associated with performing the gold standard polysomnography in children. This scoping review aims to: (1) provide an overview of the studies reporting on safe, noncontact monitoring of respiration in young children, (2) describe the accuracy of these techniques, and (3) highlight their respective advantages and limitations...
April 25, 2024: Pediatric Pulmonology
#6
JOURNAL ARTICLE
Alexandra Strauss Starling, Yue Ren, Hongzhe Li, Jonathan M Spergel, Amanda B Muir, Kristle L Lynch, Chris A Liacouras, Gary W Falk
OBJECTIVES: There is limited longitudinal data on the impact of chronic therapy on the natural history of eosinophilic esophagitis [EoE], a chronic allergic disease of the esophagus. The purpose of this study was to evaluate if patients with well-controlled EoE were less likely to develop fibrostenotic complications. METHODS: Subjects were identified from a database of pediatric EoE patients at the Children's Hospital of Philadelphia started in 2000. Patients were then searched in adult medical records to identify patients who transitioned care...
April 25, 2024: American Journal of Gastroenterology
#7
JOURNAL ARTICLE
Jason F Goldberg, Joseph A Spinner, Jonathan H Soslow
PURPOSE: While pediatric myocarditis incidence has increased since the coronavirus disease 2019 (COVID-19) pandemic, there remain questions regarding diagnosis, risk stratification, and optimal therapy. This review highlights recent publications and continued unanswered questions related to myocarditis in children. RECENT FINDINGS: Emergence from the COVID-19 era has allowed more accurate description of the incidence and prognosis of myocarditis adjacent to COVID-19 infection and vaccine administration as well that of multi-system inflammatory disease in children (MIS-C)...
April 25, 2024: Current Opinion in Cardiology
#8
REVIEW
Wei Peng, Ze-Ying Zhang, Yun-Bin Xiao
Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper mechanisms of pathogenesis remain to be elucidated. In recent years, bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis, artificial intelligence, and Mendelian randomization...
April 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#9
REVIEW
Nai-Chi Kuo, Yu Wang
Autism spectrum disorder (ASD) is one of the neurodevelopmental disorders in children, and there are currently no specific treatments, with the main interventions focusing on educational training and behavioral correction. Virtual reality, as an emerging technology, is a computer-based environmental simulation system that achieves interactive dynamics and immersive experiences by integrating information from multiple sources. In recent years, it has been gradually applied in intervention training for children with ASD...
April 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#10
REVIEW
Chiara Sassetti, Claudia Borrelli, Martha Mazuy, Ida Turrini, Donato Rigante, Susanna Esposito
Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy affecting children, being marked by chronic inflammation which mostly impacts on both skin and skeletal muscles; diagnostic criteria of JDM include an unforeseeable mixture of clinical features, while treatment modalities commonly require corticosteroids or immunosuppressant agents. Although the pathogenesis of JDM is not completely understood, several infectious triggers have been linked to its priming via anecdotal reports related to children...
2024: Frontiers in Immunology
#11
REVIEW
Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics.
Mayura R Dhamdhere, Vladimir S Spiegelman
Neuroblastoma (NB) is the most common extracranial solid pediatric cancer, and is one of the leading causes of cancer-related deaths in children. Despite the current multi-modal treatment regimens, majority of patients with advanced-stage NBs develop therapeutic resistance and relapse, leading to poor disease outcomes. There is a large body of knowledge on pathophysiological role of small extracellular vesicles (EVs) in progression and metastasis of multiple cancer types, however, the importance of EVs in NB was until recently not well understood...
2024: Frontiers in Immunology
#12
JOURNAL ARTICLE
Eric Simiele, Ignacio O Romero, Jen-Yeu Wang, Yizheng Chen, Yuliia Lozko, Yuliia Severyn, Lawrie Skinner, Yong Yang, Lei Xing, Iris Gibbs, Susan M Hiniker, Nataliya Kovalchuk
PURPOSE: Create a comprehensive automated solution for pediatric and adult VMAT-CSI including contouring, planning, and plan check to reduce planning time and improve plan quality. METHODS: Seventy-seven previously treated CSI patients (age, 2-67 years) were used for creation of an auto-contouring model to segment 25 organs at risk (OARs). The auto-contoured OARs were evaluated using the Dice Similarity Coefficient (DSC), 95% Hausdorff Distance (HD95), and a qualitative ranking by one physician and one physicist (scale: 1-acceptable, 2-minor edits, 3-major edits)...
2024: Frontiers in Oncology
#13
REVIEW
Sandra von Hardenberg, Isabel Klefenz, Doris Steinemann, Nataliya Di Donato, Ulrich Baumann, Bernd Auber, Christian Klemann
New technologies in genetic diagnostics have revolutionized the understanding and management of rare diseases. This review highlights the significant advances and latest developments in genetic diagnostics in inborn errors of immunity (IEI), which encompass a diverse group of disorders characterized by defects in the immune system, leading to increased susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, and malignancies. Various diagnostic approaches, including targeted gene sequencing panels, whole exome sequencing, whole genome sequencing, RNA sequencing, or proteomics, have enabled the identification of causative genetic variants of rare diseases...
2024: Frontiers in Pediatrics
#14
JOURNAL ARTICLE
B Caitlin Peters, Robin Gabriels, Arlene A Schmid, Rebecca K F Lassell, Zhaoxing Pan, Ari Hoffman, Susan Hepburn
There is a lack of peer-reviewed research on occupational therapy using Zones of Regulation™ concepts for autistic youth. The purpose of this article is to describe the feasibility of a newly-developed occupational therapy intervention using Zones of Regulation™ concepts (OT-ZOR) for autistic youth. Specifically, we aimed to evaluate: (a) participant recruitment, retention, and attendance; (b) intervention fidelity, safety, and assessment completion; (c) intervention acceptability; and (d) preliminary participant outcomes...
April 25, 2024: OTJR: Occupation, Participation and Health
#15
JOURNAL ARTICLE
Kevin J Orellana, Joshua T Bram, Morgan Batley, Susan Novotny, Hitesh Shah, Jennifer C Laine, Derek M Kelly, Benjamin Martin, Tim Schrader, Harry Kim, Wudbhav N Sankar
INTRODUCTION: One of the most popular containment procedures for Legg-Calvé-Perthes disease (LCPD) is proximal femur varus osteotomy (PFO). While generally successful in achieving containment, PFO can cause limb length discrepancy, abductor weakness, and (of most concern for families) a persistent limp. While many studies have focused on radiographic outcomes following containment surgery, none have analyzed predictors of this persistent limp. The aim of this study was to determine clinical, radiographic, and surgical risk factors for persistent limp 2 years after PFO in children with LCPD...
April 25, 2024: Journal of Pediatric Orthopedics
#16
JOURNAL ARTICLE
Muhammed Riyas K Rahmath, Akhlaque N Bhat, Reyaz A Lone, Reema Y Kamal
OBJECTIVE: A single centre experience with chylothorax in post cardiac surgical patients. METHODS: Retrospective review. RESULTS: Chylothorax developed in 55 out of 873 operated patients (6.3%). Median age of the chylothorax cohort was 95 days (range 1-995). Neonates constituted 36% and 49% were infants. Group-1(35 patients-treated during the years 2011-2015) included those who were managed with low fat diet initially with other standard measures including steroid, octreotide, pleurodesis, lymphangiogram or thoracic duct ligation whenever required...
April 24, 2024: Asian Cardiovascular & Thoracic Annals
#17
JOURNAL ARTICLE
Ceyhun Bozkurt, Volkan Hazar, Barış Malbora, Alphan Küpesiz, Utku Aygüneş, Tunç Fışgın, Musa Karakükçü, Barış Kuşkonmaz, Suar Çakı Kılıç, Derya Bayırlı, Özlem Arman Bilir, Koray Yalçın, Salih Gözmen, Vedat Uygun, Murat Elli, Hakan Sarbay, Funda Tayfun Küpesiz, Hatice İlgen Şaşmaz, Başak Adaklı Aksoy, Ebru Yılmaz, Fatma Visal Okur, Funda Tekkeşin, Fatma Demir Yenigürbüz, Gülcihan Özek, Abdullah Avni Atay, İkbal Ok Bozkaya, Suna Çelen, Seda Öztürkmen, Adalet Meral Güneş, Orhan Gürsel, Elif Güler, Alper Özcan, Duygu Uçkan Çetinkaya, Selime Aydoğdu, Namık Yaşar Özbek, Gülsün Karasu, Gülay Sezgin, Ömer Doğru, Davut Albayrak, Gülyüz Öztürk, Serap Aksoylar, Hayriye Daloğlu, Işık Odaman Al, Melike Sezgin Evim, Sinan Akbayram, Yurday Öncül, Emine Zengin, Canan Albayrak, Çetin Timur, Yeter Düzenli Kar, Hasan Fatih Çakmaklı, Özlem Tüfekçi, Ersin Töret, Bülent Antmen
BACKGROUND: Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. OBJECTIVES: The study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID-19 infection. METHOD: In this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID-19 between March 2020 and August 2022...
May 2024: Pediatric Transplantation
#18
JOURNAL ARTICLE
Kelly Pretorius, Sookja Kang, Eunju Choi
BACKGROUND: Sudden unexpected infant death (SUID) remains a leading cause of infant mortality; therefore, understanding parental practices of infant sleep at home is essential. Since social media analyses yield invaluable patient perspectives, understanding sleep practices in the context of safe sleep recommendations via a Facebook mothers' group is instrumental for policy makers, health care providers, and researchers. OBJECTIVE: This study aimed to identify photos shared by mothers discussing SUID and safe sleep online and assess their consistency with infant sleep guidelines per the American Academy of Pediatrics (AAP)...
April 23, 2024: JMIR Pediatrics and Parenting
#19
REVIEW
Yuanye Zhu, Jiahui Hu, Weibing Ye, Mallikarjuna Korivi, Yongdong Qian
The Peabody Developmental Motor Scales-2 (PDMS-2) has been used to assess the gross and fine motor skills of children (0-6 years); however, the measurement properties of the PDMS-2 are inconclusive. Here, we aimed to systematically review the measurement properties of PDMS-2, and synthesize the quality of evidence using the Consensus-based Standards for the Selection of Health Measurements Instruments (COSMIN) methodology. Electronic databases, including PubMed, EMBASE, Web of Science, CINAHL and MEDLINE, were searched for relevant studies through January 2023; these studies used PDMS-2...
April 24, 2024: Italian Journal of Pediatrics
#20
JOURNAL ARTICLE
Hasan M Isa, Masooma Mohamed, Ahmed Alsaei, Zahra Isa, Enjy Khedr, Afaf Mohamed, Haitham Jahrami
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease that causes anorexia, malabsorption, and increased energy requirements. Childhood IBD can significantly impact nutritional status and future health. OBJECTIVE: This study aimed to analyze the nutritional status of patients with pediatric IBD at presentation and during follow-up and to identify predictors of nutritional outcome. METHODS: This retrospective cohort study reviewed the medical records of children diagnosed with IBD in the Pediatric Department, Salmaniya Medical Complex, Bahrain, 1984 - 2023...
April 24, 2024: BMC Pediatrics
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