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https://www.readbyqxmd.com/read/29931806/the-polypeptide-n-acetylgalactosaminyltransferase-4-exhibits-stage-dependent-expression-in-colorectal-cancer-and-affects-tumorigenesis-invasion-and-differentiation
#1
Xialin Yan, Jishun Lu, Xia Zou, Sen Zhang, Yalu Cui, Leqi Zhou, Feng Liu, Aidong Shan, Jiaoyang Lu, Minghua Zheng, Bo Feng, Yan Zhang
The aberrant expression of mucin-type O-glycosylation plays important roles in the cancer malignancy. Polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) are a family of conserved enzymes that initiate the mucin-type O-glycosylation in cells. In human, consistent up- or down-regulation of ppGalNAc-Ts expression during the cancer development has been frequently reported. Here, we provide evidence that ppGalNAc-T4 shows a stage-dependent expression at the different stages of colorectal cancer (CRC) in the 62 pair-matched tumor/normal tissues...
June 22, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29926241/circulating-tumor-cell-phenotype-indicates-poor-survival-and-recurrence-after-surgery-for-hepatocellular-carcinoma
#2
Huohui Ou, Yu Huang, Leyang Xiang, Zhanjun Chen, Yinghao Fang, Yixiong Lin, Zhonglin Cui, Sheng Yu, Xianghong Li, Dinghua Yang
BACKGROUND: Circulating tumors cells (CTCs) may be a promising prognostic marker for patients with malignant tumors. However, there are few reports regarding its value for hepatocellular carcinoma (HCC) patients. AIMS: To investigate CTCs with epithelial and mesenchymal phenotypes as a potential prognostic biomarker for HCC patients. METHODS: Peripheral blood samples were obtained from 165 HCC patients before radical surgery. CTCs were isolated via the CanPatrol CTC enrichment technique and classified using epithelial-mesenchymal transition (EMT) markers...
June 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29921289/snai2-upregulation-is-associated-with-an-aggressive-phenotype-in-fulvestrant-resistant-breast-cancer-cells-and-is-an-indicator-of-poor-response-to-endocrine-therapy-in-estrogen-receptor-positive-metastatic-breast-cancer
#3
Carla L Alves, Daniel Elias, Maria B Lyng, Martin Bak, Henrik J Ditzel
BACKGROUND: Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the specific molecules and pathways involved in these altered features remain to be detailed, and may be promising therapeutic targets to overcome endocrine resistance. METHODS: In the present study, we evaluated altered expression of epithelial-mesenchymal transition (EMT) regulators in ER+ breast cancer cell models of tamoxifen or fulvestrant resistance, by gene expression profiling...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29915159/circulating-tumor-cells-undergoing-emt-provide-a-metric-for-diagnosis-and-prognosis-of-patients-with-hepatocellular-carcinoma
#4
Lu-Nan Qi, Bang-De Xiang, Fei-Xiang Wu, Jia-Zhou Ye, Jian-Hong Zhong, Yan-Yan Wang, Yuan-Yuan Chen, Zu-Shun Chen, Liang Ma, Jie Chen, Wen-Feng Gong, Ze-Guang Han, Yan Lu, Jin-Jie Shang, Le-Qun Li
To clarify the significance of circulating tumor cells (CTC) undergoing epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) patients, we used an advanced CanPatrol™ CTC-enrichment technique and in situ hybridization (ISH) to enrich and classify CTC from blood samples. 101 of 112 (90.18%) HCC patients were CTC-positive, even with early-stage disease. CTC were also detected in 2 of 12 hepatitis B virus (HBV) patients, both of whom had small HCC tumors detected within 5 months. CTC count ≥16 and mesenchymal-CTC (M-CTC) percentage ≥2% prior to resection were significantly associated with early recurrence, multi-intrahepatic recurrence, and lung metastasis...
June 18, 2018: Cancer Research
https://www.readbyqxmd.com/read/29914266/isolation-and-biological-characteristics-of-multipotent-mesenchymal-stromal-cells-derived-from-chick-embryo-intestine
#5
Jingjing Wang, Wenxiu Zhang, Kunfu Wang, Shuang Zhang, Xiao Han, Weijun Guan, Yuehui Ma
1. Over the past decade rapid advancement in isolation methods for identifying markers of the once elusive intestinal stem cell (ISC) populations have laid the foundation for unravelling their complex interrelationships during homeostasis. Study on ISC in avian intestinal tissue might play a pivotal foundation for further studies on the epithelial-to-mesenchymal transition (EMT) in gastrointestinal disease and cell-based therapy as well as intestinal tissue engineering. 2. The following experiment isolated a population of fibroblast-like, plastic adhering cells derived from chick embryo intestine, showing a strong self-renewing and proliferative ability, which was maintained in vitro up to passage 25...
June 19, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29906744/microrna-302c-represses-epithelial-mesenchymal-transition-and-metastasis-by-targeting-transcription-factor-ap-4-in-colorectal-cancer
#6
Wenqi Ma, Bailing Liu, Jie Li, Jue Jiang, Ru Zhou, Lili Huang, Xiaopeng Li, Xin He, Qi Zhou
MicroRNAs (miRNAs) contribute to tumorigenesis and progression via acting as tumor suppressors or oncogenes in human cancer. Aberrant expression of miR-302c has been reported in various types of cancer except colorectal cancer (CRC). Thus, our study was aimed to verify the expression of miR-302c and its functional role in CRC. We found a significant reduced expression of miR-302c in CRC tissues compared to tumor-adjacent tissues. Low miR-302c level was remarkably correlated with deeper tumor invasion, lymph node metastasis and advanced TNM stage...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29899406/lactb-a-novel-epigenetic-silenced-tumor-suppressor-inhibits-colorectal-cancer-progression-by-attenuating-mdm2-mediated-p53-ubiquitination-and-degradation
#7
Kaixuan Zeng, Xiaoxiang Chen, Xiuxiu Hu, Xiangxiang Liu, Tao Xu, Huiling Sun, Yuqin Pan, Bangshun He, Shukui Wang
Colorectal cancer (CRC) is one of the most common aggressive malignancies. Like other solid tumors, inactivation of tumor suppressor genes and activation of oncogenes occur during CRC development and progression. Recently, a novel tumor suppressor, LACTB, was proposed to inhibit tumor progression, but the functional and clinical significance of this tumor suppressor in CRC remains unexplored. Herein, we found LACTB was significantly downregulated in CRC due to promoter methylation and histone deacetylation, which was associated with metastasis and advanced clinical stage...
June 13, 2018: Oncogene
https://www.readbyqxmd.com/read/29888104/nudcd1-promotes-metastasis-through-inducing-emt-and-inhibiting-apoptosis-in-colorectal-cancer
#8
Bin Han, Yuan-Yuan Zhang, Ke Xu, Yang Bai, Li-Hong Wan, Shi-Kun Miao, Ke-Xian Zhang, Hong-Wei Zhang, Yin Liu, Li-Ming Zhou
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women. NudC domain containing 1 (NUDCD1) was identified as an oncoprotein which was activated or over-expressed in various human cancers. We aimed to investigate the effects and mechanisms of NUDCD1 in human CRC. The expression of NUDCD1 in CRC and pericarcinous tissues from 70 CRC patients were determined by real-time PCR, western blotting, and immunohistochemistry. The correlation between the expression of NUDCD1 and clinical characteristics was analyzed...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29882900/isoviolanthin-extracted-from-dendrobium-officinale-reverses-tgf-%C3%AE-1-mediated-epithelial%C3%A2-mesenchymal-transition-in-hepatocellular-carcinoma-cells-via-deactivating-the-tgf-%C3%AE-smad-and-pi3k-akt-mtor-signaling-pathways
#9
Shangping Xing, Wenxia Yu, Xiaofeng Zhang, Yingyi Luo, Zhouxi Lei, Dandan Huang, Ji Lin, Yuechun Huang, Shaowei Huang, Feifei Nong, Chunhua Zhou, Gang Wei
Dendrobium officinale is a precious medicinal herb and health food, and its pharmacological actions have been studied and proved. However, the mechanisms by which its active flavonoid glycosides affect epithelial⁻mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) cells, such as HepG2 and Bel-7402 cells, have not been previously investigated. Therefore, we investigated whether isoviolanthin extracted from the leaves of Dendrobium officinale inhibits transforming growth factor (TGF)-β1-induced EMT in HCC cells...
May 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29880891/snail-knockdown-reverses-stemness-and-inhibits-tumour-growth-in-ovarian-cancer
#10
N Hojo, A L Huisken, H Wang, E Chirshev, N S Kim, S M Nguyen, H Campos, C A Glackin, Y J Ioffe, J J Unternaehrer
To develop effective therapies for advanced high grade serous ovarian cancer (HGSOC), understanding mechanisms of recurrence and metastasis is necessary. In this study, we define the epithelial/mesenchymal status of cell lines that accurately model HGSOC, and evaluate the therapeutic potential of targeting Snai1 (Snail), a master regulator of the epithelial/mesenchymal transition (EMT) in vitro and in vivo. The ratio of Snail to E-cadherin (S/E index) at RNA and protein levels was correlated with mesenchymal morphology in four cell lines...
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29880874/the-distinct-role-of-strand-specific-mir-514b-3p-and-mir-514b-5p-in-colorectal-cancer-metastasis
#11
Lin-Lin Ren, Ting-Ting Yan, Chao-Qin Shen, Jia-Yin Tang, Xuan Kong, Ying-Chao Wang, Jinxian Chen, Qiang Liu, Jie He, Ming Zhong, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
The abnormal expression of microRNAs (miRNAs) in colorectal cancer (CRC) progression has been widely investigated. It was reported that the same hairpin RNA structure could generate mature products from each strand, termed 5p and 3p, which binds different target mRNAs. Here, we explored the expression, functions, and mechanisms of miR-514b-3p and miR-514b-5p in CRC cells and tissues. We found that miR-514b-3p was significantly down-regulated in CRC samples, and the ratio of miR-514b-3p/miR-514b-5p increased from advanced CRC, early CRC to matched normal colorectal tissues...
June 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29874556/autophagy-induced-by-overexpression-of-dctpp1-promotes-tumor-progression-and-predicts-poor-clinical-outcome-in-prostate-cancer
#12
Jian-Ming Lu, Wei-Min Dong, Hui-Chan He, Zhao-Dong Han, Yang-Jia Zhuo, Ru-Jun Mo, Ying-Ke Liang, Jian-Guo Zhu, Ruidong Li, Han Qu, Le Zhang, Shi-Bo Wang, Renyuan Ma, Zhenyu Jia, Wei-de Zhong
Although dCTP pyrophosphatase 1 (DCTPP1) has been reported to be associated with poor clinical outcomes in various cancers, whether it plays an important role in prostate cancer (PCa) remains unclear. In this study, an immunohistochemical assay showed the protein expression level of DCTPP1 was significantly higher in PCa tissues than in non-cancerous tissues. Moreover, DCTPP1 was upregulated at both protein and mRNA levels in the PCa tissues from high Gleason score patients versus low Gleason score patients...
June 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29873702/negative-regulation-of-tgf-%C3%AE-by-ampk-and-implications-in-the-treatment-of-associated-disorders
#13
Jiayu Gao, Jinhui Ye, Ying Ying, Hui Lin, Zhijun Luo
Transforming growth factor beta (TGF-β) regulates a large number of biological processes, including proliferation, differentiation, immune response, and development. In addition, TGF-β plays important roles in some pathological processes, for instance, it is upregulated and activated in fibrosis and advanced cancer. Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that is activated when cells sense shortage of ATP and increase in AMP or AMP:ATP ratio. Activation of AMPK slows down anabolic processes and stimulates catabolic processes, leading to increased production of ATP...
June 1, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29862993/b-lymphoma-moloney-murine-leukemia-virus-insertion-region-1-an-oncogenic-mediator-in-prostate-cancer
#14
REVIEW
Qipeng Liu, Qiaqia Li, Sen Zhu, Yang Yi, Qi Cao
B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial-mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation...
June 1, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29858701/epidemiology-biology-and-treatment-of-sarcomatoid-rcc-current-state-of-the-art
#15
REVIEW
Cedric Lebacle, Aydin Pooli, Thomas Bessede, Jacques Irani, Allan J Pantuck, Alexandra Drakaki
Long recognized to confer an extremely poor prognosis, sarcomatoid dedifferentiation of renal cell carcinoma (sRCC) is a tumor phenotype that is finally beginning to be better understood on the molecular and genetic levels. With an overall incidence that ranges from 1 to 32% depending on associated RCC subtype, the survival of sarcomatoid RCC patients rarely exceeds 2 years. The main reasons for its poor outcome include its aggressive biology, its tendency to present at an advanced or metastatic stage at the time of diagnosis, its high rate of tumor recurrence after nephrectomy, and its limited response to systemic therapies...
June 1, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29845254/high-mobility-group-box-1-promotes-the-epithelial-to-mesenchymal-transition-in-prostate-cancer-pc3-cells-via-the-rage-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Jingliang Zhang, Shuai Shao, Donghui Han, Yuerong Xu, Dian Jiao, Jieheng Wu, Fa Yang, Yufeng Ge, Shengjia Shi, Yu Li, Weihong Wen, Weijun Qin
High mobility group box 1 (HMGB1), a critical damage-associated molecular pattern molecule, has been implicated in several inflammatory diseases and cancer types. The overexpression of HMGB1 protein occurs in prostate cancer, and is closely associated with the proliferation and aggressiveness of tumor cells. However, the underlying mechanisms of HMGB1-induced tumor metastasis in prostate cancer remain unclear. In the present study, it was demonstrated that the expression of HMGB1 was high in prostate cancer samples, particularly in the metastatic tissues...
May 23, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29843425/functional-role-of-non-coding-rnas-during-epithelial-to-mesenchymal-transition
#17
REVIEW
Almudena Expósito-Villén, Amelia E Aránega, Diego Franco
Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading to filopodia formation and the progressive up-regulation of a mesenchymal gene expression pattern enabling cell migration. Epithelial-to-mesenchymal transition is already observed in early embryonic stages such as gastrulation, when the epiblast undergoes an EMT process and therefore leads to the formation of the third embryonic layer, the mesoderm...
May 28, 2018: Non-Coding RNA
https://www.readbyqxmd.com/read/29843220/long-non-coding-rna-ghet1-promotes-human-breast-cancer-cell-proliferation-invasion-and-migration-via-affecting-epithelial-mesenchymal-transition
#18
Rui Song, Jia Zhang, Junhua Huang, Tao Hai
OBJECTIVE: Breast cancer is a common malignancy in women and long non-coding RNAs (lncRNAs) have been shown to play key roles in the development and progression of breast cancer. In the present study, we examined the biological role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in breast cancer. METHODS: The expression of GHET1 was determined by qRT-PCR assay; CCK-8, colony formation, Transwell invasion and migration assays detected breast cancer cell proliferation, invasion and migration; cell apoptosis and cell cycle were determined by flow cytometry; protein levels were determined by western blot assay...
May 11, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29842879/oxaliplatin-and-irinotecan-induce-heterogenous-changes-in-the-emt-markers-of-metastasizing-colorectal-carcinoma-cells
#19
Skarkova Veronika, Kralova Vera, Krbal Lukas, Matouskova Petra, Soukup Jiri, Rudolf Emil
In patients with advanced colorectal cancer (CRC), surgery is complemented with systemic therapy - chemotherapy and radiochemotherapy. Although the patients' overall survival has been significantly improved, tumor resistance is still a frequent cause of chemotherapy failure. Several factors contribute to chemoresistance of tumor cells including changes related with epithelial-mesenchymal transition (EMT). The present study was designed to verify the presence of EMT markers in paired CRC primary cell lines obtained from primary tumor sites and lymph node metastases of three patients and to investigate the effect of irinotecan and oxaliplatin treatment on these markers as well...
May 26, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29805559/trim59-induces-epithelial-to-mesenchymal-transition-and-promotes-migration-and-invasion-by-pi3k-akt-signaling-pathway-in-medulloblastoma
#20
Ran Gao, Guoqing Lv, Cuicui Zhang, Xiaoli Wang, Lijing Chen
Medulloblastoma is the most common malignant brain tumor in children. Despite remarkable advances over previous decades, the long-term survival of patients with medulloblastoma remains poor due to the frequent metastatic nature of this malignancy. The aim of the present study was to examine the role of tripartite motif containing 59 (TRIM59) in cell metastasis in medulloblastoma. It was initially demonstrated that TRIM59 expression was significantly increased in clinical medulloblastoma tissues compared with adjacent non-cancerous tissues and differentially expressed in a series of medulloblastoma cell lines...
June 2018: Oncology Letters
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