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https://www.readbyqxmd.com/read/29468726/immunohistochemical-expression-of-cd44-in-oral-squamous-cell-carcinoma-in-relation-to-histomorphologic-parameters-and-clinicopathological-factors
#1
Melanie Boxberg, Carolin Götz, Selgai Haidari, Christiane Dorfner, Moritz Jesinghaus, Enken Drecoll, Marko Boskov, Klaus Dietrich Wolff, Wilko Weichert, Bernhard Haller, Andreas Kolk
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is characterized by its variable clinical course. In addition to the routinely used TNM/UICC systems, patient-specific prognostic/predictive biomarkers are needed. Promising biomarkers include the determination of the cancer stem cell (CSC) compartment, which can be identified by CD44 expression (amongst others). MATERIALS AND METHODS: A well-characterized cohort of 108 therapy-naïve OSCC with complete long-term follow-up and matched lymph node metastases were evaluated for CD44 expression by immunohistochemistry...
February 22, 2018: Histopathology
https://www.readbyqxmd.com/read/29467947/metformin-inhibits-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-like-process-and-stem-like-properties-in-gbm-via-akt-mtor-zeb1-pathway
#2
Yang Song, Yong Chen, Yunqian Li, Xiaoyan Lyu, Jiayue Cui, Ye Cheng, Liyan Zhao, Gang Zhao
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. In spite of advances in diagnosis and therapy, the prognosis is still relatively poor. The invasive property of GBM is the major cause of death in patients. Epithelial-to-mesenchymal transition-like process (EMT-like process) is considered to play an important role in the invasive property. Metformin has been reported as a regulator of EMT-like process. In this study, we confirmed that metformin inhibited TGF-β1-induced EMT-like process and EMT-associated migration and invasion in LN18 and U87 GBM cells...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464030/under-expression-of-ck2%C3%AE-subunit-in-ccrcc-represents-a-complementary-biomarker-of-p-stat3-ser727-that-correlates-with-patient-survival
#3
Jordi Vilardell, Estefania Alcaraz, Eduard Sarró, Enric Trilla, Thaïs Cuadros, Inés de Torres, Maria Plana, Santiago Ramón Y Cajal, Lorenzo A Pinna, Maria Ruzzene, Juan Morote, Anna Meseguer, Emilio Itarte
Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of renal cancer. STAT3 pathway is altered in these tumors and p-STAT3 Ser727 is an independent prognostic factor for ccRCC. Protein kinase CK2 is altered in different types of tumors and overexpression of CK2α is considered predictive of bad prognosis and metastatic risk. CK2 subunits analyses in ccRCC samples showed increased CK2α/α' nuclear content in all cases, but decreased cytosolic CK2β (CK2βcyt) levels in the more advanced tumors...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464029/the-protein-kinase-sik-downregulates-the-polarity-protein-par3
#4
Michael Vanlandewijck, Mahsa Shahidi Dadras, Marta Lomnytska, Tanzila Mahzabin, Martin Lee Miller, Christer Busch, Søren Brunak, Carl-Henrik Heldin, Aristidis Moustakas
The multifunctional cytokine transforming growth factor β (TGFβ) controls homeostasis and disease during embryonic and adult life. TGFβ alters epithelial cell differentiation by inducing epithelial-mesenchymal transition (EMT), which involves downregulation of several cell-cell junctional constituents. Little is understood about the mechanism of tight junction disassembly by TGFβ. We found that one of the newly identified gene targets of TGFβ, encoding the serine/threonine kinase salt-inducible kinase 1 (SIK), controls tight junction dynamics...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29462126/plasticity-and-intratumoural-heterogeneity-of-cell-surface-antigen-expression-in-breast-cancer
#5
Ján Remšík, Radek Fedr, Jiří Navrátil, Lucia Binó, Eva Slabáková, Pavel Fabian, Marek Svoboda, Karel Souček
BACKGROUND: The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. METHODS: We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial-mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal counterparts. Using multicolour flow cytometry, we then analysed the expression of 10 most robustly changed antigens and identified a 10-molecule surface signature, in pan-cytokeratin-positive/EpCAM-positive and -negative fractions of dissociated breast tumours...
February 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29456682/l1cam-promotes-epithelial-to-mesenchymal-transition-and-formation-of-cancer-initiating-cells-in-human-endometrial-cancer
#6
Jinlong Chen, Fufeng Gao, Naifu Liu
Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT with increased formation of CICs in HEC-1A endometrial cancer cells. CICs and mesenchymal status resist chemotherapeutic drugs and may regenerate the various cell types in tumors, thereby resulting in relapse of the disease...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451178/involvement-of-epithelial-mesenchymal-transition-in-liver-fibrosis
#7
REVIEW
Kangkang Yu, Qian Li, Guangfeng Shi, Ning Li
Fibrosis of the liver is an inherent wound healing response to chronic liver injury. Regeneration of liver epithelium and restoration of normal liver structure were generally involved in this process. Although the liver has a striking capacity to adapt to damage through tissue repair, excessive accumulation of extracellular matrix during this process often leads to scar tissue formation and subsequent fibrosis. Epithelial to mesenchymal transition (EMT) enables a polarized epithelial cell to undergo multiple changes biochemically and to bear a mesenchymal cell phenotype...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29430187/the-lncrna-pcat1-is-correlated-with-poor-prognosis-and-promotes-cell-proliferation-invasion-migration-and-emt-in-osteosarcoma
#8
Xuedong Zhang, Yakui Zhang, Yong Mao, Xinlong Ma
Introduction: Osteosarcoma is a malignant primary bone cancer and is lethal to children and adolescents. Recently, the dysregulation of long noncoding RNAs (lncRNAs) has been shown in various types of cancers. Aim: The present study aimed to examine the role of the lncRNA prostate cancer-associated transcript 1 (PCAT1) in osteosarcoma progression. Materials and methods: The expression levels of relevant genes in clinical samples and cell lines were determined by quantitative real-time polymerase chain reaction...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29427302/multiple-roles-of-sim2-in-esophageal-squamous-cell-carcinoma-and-its-clinical-implications
#9
Masashi Tamaoki, Rie Komatsuzaki, Masayuki Komatsu, Keiko Minashi, Kazuhiko Aoyagi, Takao Nishimura, Fumiko Chiwaki, Tomoko Hiroki, Hiroyuki Daiko, Kazuhiro Morishita, Yoshiharu Sakai, Hiroshi Seno, Tsutomu Chiba, Manabu Muto, Teruhiko Yoshida, Hiroki Sasaki
The degree of histological differentiation is an important characteristic of cancers and may be associated with their malignant potentials. However, in squamous cell carcinomas, a key transcriptional factor to regulate tumor differentiation is largely unknown. Chemoradiotherapy (CRT) is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC); however, the survival rate is still below 40%. From microarray data, SIM2 was overexpressed in the epithelial subtype. Here, we investigated the correlation between SIM2 expression and its clinical implication and in vitro and in vivo functions of SIM2 in tumor differentiation and in CRT sensitivity...
February 10, 2018: Cancer Science
https://www.readbyqxmd.com/read/29414248/epithelial-mesenchymal-transition-in-tumor-metastasis
#10
Vivek Mittal
Metastasis is the major cause of cancer-related deaths; therefore, the prevention and treatment of metastasis are fundamental to improving clinical outcomes. Epithelial mesenchymal transition (EMT), an evolutionarily conserved developmental program, has been implicated in carcinogenesis and confers metastatic properties upon cancer cells by enhancing mobility, invasion, and resistance to apoptotic stimuli. Furthermore, EMT-derived tumor cells acquire stem cell properties and exhibit marked therapeutic resistance...
January 24, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/29412104/radiation-induced-pulmonary-epithelial-mesenchymal-transition-a-review-of-targeting-molecular-pathways-and-mediators
#11
S N Sunilgowda, Devipriya Nagarajan, Devipriya Nagarajan
Radiotherapy is the most widely used treatment method for average and advanced lung cancer patients. Moreover, the clinical toxicities caused by radiotherapy are categorized into acute radiation pneumonitis and late pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a complex physiological process involves many signaling molecules and proteins like adaptor proteins, and transcriptional factors. It was identified as a significant mechanism for fibrosis, wound healing and also cancer. A variety of biomarkers have appeared in radiation-induced lung EMT, some of which are acquired (N-cadherin, vimentin and fibronectin, etc...
February 6, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29408492/transcriptomic-analyses-of-chemokines-reveal-that-down-regulation-of-xcr1-is-associated-with-advanced-hepatocellular-carcinoma
#12
Wang Yanru, Bai Zhenyu, Niu Zhengchuan, Qi Qi, Liang Chunmin, Yao Weiqiang
Chemokines are essential coordinators of cellular migration and cell-cell interactions, therefore considerable attention has been paid to the application of chemokines to cancer immunotherapy. In this study, we screened for the expression levels of 58 human chemokines/chemokine receptors in hepatocellular carcinoma (HCC) by using samples from the TCGA LIHC cohort and found 16 consistently down-regulated and 11 up-regulated chemokine genes in HCC compared with normal samples. Furthermore, the expressions of XCR1 were verified by Western blot in liver cancer cell lines...
February 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29405291/up-regulated-n-cadherin-expression-is-associated-with-poor-prognosis-in-epithelial-derived-solid-tumors-a-meta-analysis
#13
REVIEW
Yong Luo, Ting Yu, Qiongwen Zhang, Qingyu Fu, Yuzhu Hu, Mengmeng Xiang, Haoning Peng, Tianying Zheng, Li Lu, Huashan Shi
BACKGROUND: N-cadherin is an important molecular in epithelial-mesenchymal transition (EMT), and has been reported to be associated with aggressive behaviors of tumors. However, prognostic value of N-cadherin in solid malignances remains controversially. MATERIALS AND METHODS: The Pubmed/MELINE and EMBASE databases were used for a comprehensive literature searching. Pooled risk ratio (RR) and hazard ratio (HR) with their corresponding 95% confidence intervals (CIs) were employed to quantify the prognostic role...
February 5, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29393475/fndc3b-promotes-epithelial-mesenchymal-transition-in-tongue-squamous-cell-carcinoma-cells-in-a-hypoxic-microenvironment
#14
Zhaoming Zhong, Hongxing Zhang, Min Hong, Chuanzheng Sun, Yuanyuan Xu, Xiao Chen, Change Gao, Minjie He, Weiqing Liu, Jin Liang
The primary reasons for the treatment failure of patients with oral tongue squamous cell carcinoma (OTSCC) are metastasis and tumor recurrence. Identifying the exact mechanisms underlying metastasis is a key point in improving patient prognosis. It has been reported that a hypoxic microenvironment plays an important role during the metastasis of malignancies. We found that the expression of fibronectin type III domain containing 3B (FNDC3B) is positively correlated with lymph node metastasis and advanced cTNM stage of OTSCC by IHC assay and correlation analysis...
January 24, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29393450/cullin7-promotes-epithelial%C3%A2-mesenchymal-transition-of-esophageal-carcinoma-via-the-erk%C3%A2-snai2-signaling-pathway
#15
Ping Tian, Dandan Liu, Luyi Sun, Hui Sun
Cullin7 (CUL7) is a member of Cullin protein family and exhibits a tumor‑promoting role in several types of tumors, including breast, liver and ovarian. However, its roles in esophageal carcinoma (EC) have not yet been reported. In the present study, CUL7 expression in EC tissue was revealed to be significantly higher compared with nontumoral tissues, as detected by immunohistochemistry (IHC; P=0.000). χ2 analysis confirmed that CUL7 expression was positively associated with invasion depth (P=0.000), lymph node involvement (P=0...
January 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29388209/the-role-of-the-mir-200-family-in-epithelial-mesenchymal-transition-in-colorectal-cancer-a-systematic-review
#16
Stephen J O'Brien, Jane V Carter, James F Burton, Brent G Oxford, Miranda N Schmidt, Jacob C Hallion, Susan Galandiuk
Colorectal cancer is associated with significant morbidity and mortality as many patients are diagnosed with advanced stage disease. MicroRNAs are small, non-coding RNA molecules which have a major role in gene expression regulation and are dysregulated in colorectal cancer. The miR-200 family is involved in epithelial-to-mesenchymal transition (EMT). This systematic review describes the roles of the miR-200 family in EMT in colorectal cancer. A search of electronic databases (PubMed and Embase) was conducted between January 2000 and July 2017...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29386088/phosphoglycerate-mutase-1-pgam1-promotes-pancreatic-ductal-adenocarcinoma-pdac-metastasis-by-acting-as-a-novel-downstream-target-of-pi3k-akt-mtor-pathway
#17
Xinlu Liu, Xiaodong Tan, Peng Liu, Yunhao Wu, Songying Qian, Xiaobo Zhang
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors known, with an overall 5-year survival rate of less than 6% due to early local invasion and distant metastasis. Exploring suitable therapeutic targets associated with invasion and metastasis is required for improving the prognosis of PDAC. In this study, we investigated the role of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) in PDAC. PGAM1 expression was examined in tissue samples of 54 PDAC patients using immunohistochemistry, and the correlation between clinicopathological expression and PGAM1 expression was determined...
January 31, 2018: Oncology Research
https://www.readbyqxmd.com/read/29385918/magnetic-resonance-guided-high-intensity-focused-ultrasound-sonolysis-potential-applications-for-stroke
#18
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Andrew Romeo, Thomas J Buell, Tony R Wang, M Yashar S Kalani, Min S Park
Stroke is one of the leading causes of death worldwide and a significant source of long-term morbidity. Unfortunately, a substantial number of stroke patients either are ineligible or do not significantly benefit from contemporary medical and interventional therapies. To address this void, investigators recently made technological advances to render transcranial MR-guided, high-intensity focused ultrasound (MRg-HIFU) sonolysis a potential therapeutic option for both acute ischemic stroke (AIS)-as an alternative for patients with emergent large-vessel occlusion (ELVO) who are ineligible for endovascular mechanical thrombectomy (EMT) or as salvage therapy for patients in whom EMT fails-and intracerebral hemorrhage (ICH)-as a neoadjuvant means of clot lysis prior to surgical evacuation...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29384527/bone-marrow-derived-mesenchymal-stromal-cells-promote-colorectal-cancer-cell-death-under-low-dose-irradiation
#19
Hao Feng, Jing-Kun Zhao, Tobias S Schiergens, Pu-Xiongzhi Wang, Bao-Chi Ou, Rami Al-Sayegh, Ming-Lun Li, Ai-Guo Lu, Shuai Yin, Wolfgang E Thasler
BACKGROUND: Radiotherapy remains one of the cornerstones to improve the outcome of colorectal cancer (CRC) patients. Radiotherapy of the CRC not only help to destroy cancer cells but also remodel the tumour microenvironment by enhancing tumour-specific tropism of bone marrow-derived mesenchymal stromal cell (BM-MSC) from the peripheral circulation. However, the role of local MSCs and recruited BM-MSC under radiation were not well defined. Indeed, the functions of BM-MSC without irradiation intervention remained controversial in tumour progression: BM-MSC was previously shown to modulate the immune function of major immune cells, resulting in an impaired immunological sensitivity and to induce an increased risk of tumour recurrence...
February 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29364743/comparison-of-the-i-gel-supraglottic-and-king-laryngotracheal-airways-in-a-simulated-tactical-environment
#20
Juan A March, Theresa E Tassey, Noel B Resurreccion, Roberto C Portela, Stephen E Taylor
BACKGROUND: When working in a tactical environment there are several different airway management options that exist. One published manuscript suggests that when compared to endotracheal intubation, the King LT laryngotracheal airway (KA) device minimizes time to successful tube placement and minimizes exposure in a tactical environment. However, comparison of two different blind insertion supraglottic airway devices in a tactical environment has not been performed. This study compared the I-Gel airway (IGA) to the KA in a simulated tactical environment, to determine if one device is superior in minimizing exposure and minimizing time to successful tube placement...
January 24, 2018: Prehospital Emergency Care
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