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https://www.readbyqxmd.com/read/27914016/ms-ms-assisted-design-of-sequence-controlled-synthetic-polymers-for-improved-reading-of-encoded-information
#1
Laurence Charles, Gianni Cavallo, Valérie Monnier, Laurence Oswald, Roza Szweda, Jean-François Lutz
In order to improve their MS/MS sequencing, structure of sequence-controlled synthetic polymers can be optimized based on considerations regarding their fragmentation behavior in collision-induced dissociation conditions, as demonstrated here for two digitally encoded polymer families. In poly(triazole amide)s, the main dissociation route proceeded via cleavage of the amide bond in each monomer, hence allowing the chains to be safely sequenced. However, a competitive cleavage of an ether bond in a tri(ethylene glycol) spacer placed between each coding moiety complicated MS/MS spectra while not bringing new structural information...
December 2, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27907856/cdna-aflp-analysis-of-transcripts-induced-in-chickpea-plants-by-tio2-nanoparticles-during-cold-stress
#2
Saeed Amini, Reza Maali-Amiri, Rahmat Mohammadi, Seyyedeh-Sanam Kazemi-Shahandashti
We evaluated the effect of TiO2 nanoparticles (NPs) on cold tolerance (CT) development in two chickpea (Cicer arietinum L.) genotypes (Sel96Th11439, cold tolerant, and ILC533, cold susceptible) by using cDNA-amplified fragment length polymorphism (cDNA-AFLP) technique during the first and sixth days of cold stress (CS) at 4 °C. Selective amplification by primer combinations generated 4200 transcript-derived fragments (TDFs) while 100 of them (2.62%) were differentially expressed. During CS, 60 differentially expressed TDFs of TiO2 NPs-treated plants were cloned and 10 of them produced successfully readable sequences...
November 22, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27903952/how-readable-is-bph-treatment-information-on-the-internet-assessing-barriers-to-literacy-in-prostate-health
#3
Kevin Koo, Ronald L Yap
Information about benign prostatic hyperplasia (BPH) has become increasingly accessible on the Internet. Though the ability to find such material is encouraging, its readability and impact on informing patient decision making are not known. To evaluate the readability of Internet-based information about BPH in the context of website ownership and Health on the Net certification, three search engines were queried daily for 1 month with BPH-related keywords. Website ownership data and Health on the Net certification status were verified...
November 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27882823/the-transparency-of-published-health-technology-assessment-based-recommendations-on-pharmaceutical-reimbursement-in-poland
#4
Tomasz Bochenek, Ewa Kocot, Marcin Rodzinka, Brian Godman, Katarzyna Maciejewska, Susan Kamal, Andrzej Pilc
BACKGROUND: The appropriate access to public information is very important for healthcare system stakeholders. OBJECTIVE: The goal of this study was to examine how the execution of the formally existing right to public information on the HTA-based recommendations on reimbursement of new health technologies from public funds has been changing in Poland. METHODS: All recommendations published within two predefined equal periods of time between 2013 and 2015 were analyzed...
November 24, 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27878059/assessment-of-online-patient-education-materials-from-major-dermatologic-associations
#5
Ann M John, Elizabeth S John, David R Hansberry, William Clark Lambert
Objective: Patients increasingly use the internet to find medical information regarding their conditions and treatments. Physicians often supplement visits with written education materials. Online patient education materials from major dermatologic associations should be written at appropriate reading levels to optimize utility for patients. The purpose of this study is to assess online patient education materials from major dermatologic associations and determine if they are written at the fourth to sixth grade level recommended by the American Medical Association and National Institutes of Health...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27875175/proact-iterative-design-of-a-patient-centered-visualization-for-effective-prostate-cancer-health-risk-communication
#6
Anzu Hakone, Lane Harrison, Alvitta Ottley, Nathan Winters, Caitlin Gutheil, Paul K J Han, Remco Chang
Prostate cancer is the most common cancer among men in the US, and yet most cases represent localized cancer for which the optimal treatment is unclear. Accumulating evidence suggests that the available treatment options, including surgery and conservative treatment, result in a similar prognosis for most men with localized prostate cancer. However, approximately 90% of patients choose surgery over conservative treatment, despite the risk of severe side effects like erectile dysfunction and incontinence. Recent medical research suggests that a key reason is the lack of patient-centered tools that can effectively communicate personalized risk information and enable them to make better health decisions...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27874913/metal-on-metal-total-hip-arthroplasty-quality-of-online-patient-information
#7
Geoff Crozier-Shaw, Joseph M Queally, John F Quinlan
Metal-on-metal total hip arthroplasty (THA) has generated much attention in the media because of early failure of certain implant systems. This study assessed the quality, accuracy, and readability of online information on metal-on-metal THA. The search terms "metal-on-metal hip replacement" and "metal hip replacement" were entered into the 3 most popular search engines. Information quality was assessed with the DISCERN score and a specific metal-on-metal THA content score. Accuracy of information was assessed with a customized score...
November 22, 2016: Orthopedics
https://www.readbyqxmd.com/read/27874852/a-global-gas-flaring-black-carbon-emission-rate-dataset-from-1994-to-2012
#8
Kan Huang, Joshua S Fu
Global flaring of associated petroleum gas is a potential emission source of particulate matters (PM) and could be notable in some specific regions that are in urgent need of mitigation. PM emitted from gas flaring is mainly in the form of black carbon (BC), which is a strong short-lived climate forcer. However, BC from gas flaring has been neglected in most global/regional emission inventories and is rarely considered in climate modeling. Here we present a global gas flaring BC emission rate dataset for the period 1994-2012 in a machine-readable format...
November 22, 2016: Scientific Data
https://www.readbyqxmd.com/read/27868070/adaptation-and-feasibility-study-of-a-digital-health-program-to-prevent-diabetes-among-low-income-patients-results-from-a-partnership-between-a-digital-health-company-and-an-academic-research-team
#9
Valy Fontil, Kelly McDermott, Lina Tieu, Christina Rios, Eliza Gibson, Cynthia Castro Sweet, Mike Payne, Courtney R Lyles
Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We conducted focus groups to assess patient perspectives, revised lessons for improved readability and cultural relevance to low-income and Hispanic patients, conducted a feasibility study of the adapted program in English and Spanish speaking cohorts, and implemented real-time adaptations to the program for commercial use and for a larger trial of in multiple safety net clinics...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27862739/variability-of-respiratory-rate-measurements-in-children-suspected-with-non-severe-pneumonia-in-north-east-tanzania
#10
Florida Muro, Neema Mosha, Helena Hildenwall, Frank Mtei, Nicole Harrison, David Schellenberg, Raimos Olomi, Hugh Reyburn, Jim Todd
OBJECTIVE: Measurement of respiratory rate is an important clinical sign in the diagnosis of pneumonia but suffers from inter-observer variation. Here we assess the use of video recordings as a quality assurance tool that could be useful both in research and in training of staff. METHODS: Respiratory rates (RR) were recorded in children aged 2 - 59 months presenting with cough or difficulty breathing at two busy outpatient clinics in Tanzania. Measurements were repeated at 10-minute intervals in a quiet environment with simultaneous video recordings that were independently reviewed by two paediatricians...
November 14, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27860316/prevalence-of-myopic-retinopathy-in-rural-central-india
#11
Jost B Jonas, Vinay Nangia, Rajesh Gupta, Krishna Bhojwani, Prabhat Nangia, Songhomitra Panda-Jonas
PURPOSE: The aim of this study was to determine the prevalence of myopic retinopathy (MR) in rural Central India. METHODS: The population-based Central India Eye and Medical Study included 4711 subjects (aged 30+ years). The participants underwent a detailed eye examination, including fundus photography. Myopic retinopathy was defined according to the Pathologic Myopia Study Group. RESULTS: Readable fundus photographs were available on 4561 (96...
November 17, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27832406/electrophysiological-testing-of-visual-function-after-mirror-telescope-implantation-a-case-report
#12
Jan Kremláček, Naďa Jirásková, Jana Nekolová, Radovan Šikl, Miroslav Kuba
PURPOSE: The implantation of an intraocular telescope increases life quality in patients with end-stage age-related macular degeneration (AMD). The present study monitored changes in electrophysiological markers of visual processing before and during seventeen months after a novel mirror telescope implantation in two patients (OV-male 90 years, MZ-female 70 years) with the final-stage form of AMD. METHODS: Visual evoked potentials were recorded to high-contrast pattern-reversal (PR-VEP for check size 40' and 10'), low-contrast motion-onset stimuli (in visual periphery M-VEP M20°, and in central part M-VEP C8°), and event-related potentials (ERPs) in the oddball visual paradigm...
November 10, 2016: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/27822565/teleconsent-a-novel-approach-to-obtain-informed-consent-for-research
#13
Brandon M Welch, Elizabeth Marshall, Suparna Qanungo, Ayesha Aziz, Marilyn Laken, Leslie Lenert, Jihad Obeid
Lack of recruitment of qualified research participants continues to be a significant bottleneck in clinical trials, often resulting in costly time extensions, underpowered results, and in some cases early termination. Some of the reasons for suboptimal recruitment include laborious consent processes and access to participants at remote locations. While new electronic consents technologies (eConsent) help overcome challenges related to readability and consent management, they do not adequately address challenges related to remote access...
August 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27818214/-what-do-patients-want-tailoring-medicines-information-to-meet-patients-needs
#14
Amber Young, June Tordoff, Alesha Smith
Medicines information leaflets can equip patients to be in control of their own healthcare and support the safe and effective use of medicines. The design and content of leaflets influences patients' willingness to read them, and poor examples can cause patient confusion and anxiety. Researchers examined the literature over the past 8 years to determine the content and design of medicine information leaflets that patients prefer in order to read, understand, and use them effectively. It was found that existing leaflets do not meet patients' needs and appear ineffective...
October 26, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27814775/a-metal-artifact-reduction-method-for-a-dental-ct-based-on-adaptive-local-thresholding-and-prior-image-generation
#15
Mohamed A A Hegazy, Min Hyoung Cho, Soo Yeol Lee
BACKGROUND: Metal artifacts appearing as streaks and shadows often compromise readability of computed tomography (CT) images. Particularly in a dental CT in which high resolution imaging is crucial for precise preparation of dental implants or orthodontic devices, reduction of metal artifacts is very important. However, metal artifact reduction algorithms developed for a general medical CT may not work well in a dental CT since teeth themselves also have high attenuation coefficients...
November 4, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27812680/critical-analysis-of-the-quality-readability-and-technical-aspects-of-online-information-provided-for-neck-lifts
#16
Hani Rayess, Giancarlo F Zuliani, Amar Gupta, Peter F Svider, Adam J Folbe, Jean Anderson Eloy, Michael A Carron
Importance: The number of patients using the internet to obtain health information is growing. This material is unregulated and heterogeneous and can influence patient decisions. Objective: To compare the quality, readability, and technical aspects of online information about neck-lifts provided by private practice websites vs academic medical centers and reference sources. Design, Setting, and Participants: In this cross-sectional analysis conducted between November 2015 and January 2016, a Google search of the term neck-lift was performed, and the first 45 websites were evaluated...
November 3, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27794197/readability-analysis-of-online-health-information-about-overactive-bladder
#17
Kevin Koo, Kevin Shee, Ronald L Yap
AIMS: Despite the prevalence of overactive bladder (OAB) and the widespread accessibility of patient education information on the Internet, the readability of this information and its potential impact on patient decision-making are not known. This study evaluates the readability of OAB material online in the context of website ownership and the Health on the Net standard for information reliability. METHODS: Three Internet search platforms were queried daily with OAB-related keywords for 30 days...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27786409/the-quality-of-information-about-sickle-cell-disease-on-the-internet-for-youth
#18
Vicky R Breakey, Lauren Harris, Omar Davis, Arnav Agarwal, Carley Ouellette, Elizabeth Akinnawo, Jennifer Stinson
BACKGROUND: Adolescence is a vulnerable time for teens with sickle cell disease (SCD). Although there is evidence to support the use of web-based education to promote self-management skills in patients with chronic illnesses, the quality of SCD-related information on the Internet has not been assessed. PROCEDURE: A website review was conducted to appraise the quality, content, accuracy, readability, and desirability of online information for the adolescents with SCD...
October 27, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27780259/doing-it-your-way-how-individual-movement-styles-affect-action-prediction
#19
Atesh Koul, Andrea Cavallo, Caterina Ansuini, Cristina Becchio
Individuals show significant variations in performing a motor act. Previous studies in the action observation literature have largely ignored this ubiquitous, if often unwanted, characteristic of motor performance, assuming movement patterns to be highly similar across repetitions and individuals. In the present study, we examined the possibility that individual variations in motor style directly influence the ability to understand and predict others' actions. To this end, we first recorded grasping movements performed with different intents and used a two-step cluster analysis to identify quantitatively 'clusters' of movements performed with similar movement styles (Experiment 1)...
2016: PloS One
https://www.readbyqxmd.com/read/27779619/a-database-of-human-exposomes-and-phenomes-from-the-us-national-health-and-nutrition-examination-survey
#20
Chirag J Patel, Nam Pho, Michael McDuffie, Jeremy Easton-Marks, Cartik Kothari, Isaac S Kohane, Paul Avillach
The National Health and Nutrition Examination Survey (NHANES) is a population survey implemented by the Centers for Disease Control and Prevention (CDC) to monitor the health of the United States whose data is publicly available in hundreds of files. This Data Descriptor describes a single unified and universally accessible data file, merging across 255 separate files and stitching data across 4 surveys, encompassing 41,474 individuals and 1,191 variables. The variables consist of phenotype and environmental exposure information on each individual, specifically (1) demographic information, physical exam results (e...
October 25, 2016: Scientific Data
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