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Samir gupta

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https://www.readbyqxmd.com/read/28396605/bypassing-adverse-injection-reactions-to-nanoparticles-through-shape-modification-and-attachment-to-erythrocytes
#1
Peter Pope Wibroe, Aaron C Anselmo, Per H Nilsson, Apoorva Sarode, Vivek Gupta, Rudolf Urbanics, Janos Szebeni, Alan Christy Hunter, Samir Mitragotri, Tom Eirik Mollnes, Seyed Moein Moghimi
Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust pulmonary intravascular macrophage clearance of nanoparticles in mediating adverse cardiopulmonary distress in pigs irrespective of complement activation...
April 10, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28392909/neurogenetic-analysis-of-childhood-disintegrative-disorder
#2
Abha R Gupta, Alexander Westphal, Daniel Y J Yang, Catherine A W Sullivan, Jeffrey Eilbott, Samir Zaidi, Avery Voos, Brent C Vander Wyk, Pam Ventola, Zainulabedin Waqar, Thomas V Fernandez, A Gulhan Ercan-Sencicek, Michael F Walker, Murim Choi, Allison Schneider, Tammy Hedderly, Gillian Baird, Hannah Friedman, Cara Cordeaux, Alexandra Ristow, Frederick Shic, Fred R Volkmar, Kevin A Pelphrey
BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28376229/optimizing-the-quality-of-the-colorectal-cancer-screening-continuum-a-call-to-action
#3
Samir Gupta, Jesse Nodora
No abstract text is available yet for this article.
May 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28369419/bone-mineral-density-reductions-after-tenofovir-disoproxil-fumarate-initiation-and-changes-in-phosphaturia-a-secondary-analysis-of-actg-a5224s
#4
Samir K Gupta, Eunice Yeh, Douglas W Kitch, Todd T Brown, Charles S Venuto, Gene D Morse, Belinda Ha, Kathleen Melbourne, Grace A McComsey
Background: It is unknown if the greater reductions in bone mineral density (BMD) associated with initiation of tenofovir disoproxil fumarate compared with abacavir in previously untreated HIV-infected participants in the ACTG A5224s clinical trial were associated with potentially worsening tenofovir-related phosphaturia. Methods: We correlated changes in BMD at the hip and spine with changes in phosphaturia [transtubular reabsorption of phosphorus (TRP) and tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR)] from entry through week 96 in those initiating tenofovir ( n  =   134) versus abacavir ( n  =   135) with efavirenz or atazanavir/ritonavir in A5224s...
March 20, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28329303/high-burden-of-antimicrobial-resistance-and-mortality-among-adults-and-children-with-community-onset-bacterial-infections-in-india
#5
Vidya Mave, Ajay Chandanwale, Anju Kagal, Sandhya Khadse, Dileep Kadam, Renu Bharadwaj, Vaishali Dohe, Matthew Robinson, Aarti Kinikar, Samir Joshi, Priyanka Raichur, Katie McIntire, Savita Kanade, Jonathan Sachs, Chhaya Valvi, Usha Balasubramanian, Vandana Kulkarni, Aaron M Milstone, Ivan Marbaniang, Jonathan Zenilman, Amita Gupta
Background.: In India, antimicrobial consumption is high, yet systematically collected data on the epidemiology, risk factors and outcomes of antimicrobial resistant (AMR) infections are limited. Methods.: A prospective study of adults and children hospitalized for acute febrile illness (AFI) was conducted between August 2013 and December 2015. In-hospital outcomes were recorded, and logistic regression was performed to identify independent predictors of AMR community-onset infections...
March 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28303828/high-prevalence-of-cryptococcal-antigenaemia-amongst-asymptomatic-advanced-hiv-patients-in-pune-india
#6
Dileep Kadam, Ajay Chandanwale, Renu Bharadwaj, Neetal Nevrekar, Samir Joshi, Sandesh Patil, Nikhil Gupte, Shashi Sangle, Kavita Chopade, Vandana Kulkarni, Usha Balasubramanian, Nishi Suryavanshi, Divyashri Jain, Savita Kanade, Sujata Dharmashale, Anju Kagal, Amita Gupta, Vidya Mave
BACKGROUND: The World Health Organization recommends routine cryptococcal antigen (CrAg) screening in advanced AIDS patients initiating antiretroviral treatment (ART). India has yet to adopt this strategy as the burden of cryptococcal antigenaemia is unknown. METHODS: A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28302500/development-and-evaluation-of-an-online-resource-for-hepatopulmonary-syndrome-patients-and-caregivers-www-hpscare-com
#7
Justina Marianayagam, Katherine Griffin, Jenna Sykes, Samir Gupta
No abstract text is available yet for this article.
March 14, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28217721/point-of-sale-tobacco-advertising-remains-prominent-in-mumbai-india
#8
Samir S Khariwala, Apurva Garg, Irina Stepanov, Prakash C Gupta, Jasjit S Ahluwalia, Vikram Gota, Pankaj Chaturvedi
OBJECTIVES: In India, a 2003 law ("COPTA") banned tobacco advertising with the exception of "point of sale" and "on-pack" advertising. Given substantial evidence regarding the impact of point of sale advertising (PoS), we analyzed the prevalence of encountering such advertising in Mumbai, India. METHODS: A survey was conducted of 199 current and recent former tobacco users recruited at the Tata Memorial Hospital (Mumbai). Enrollees were queried regarding their exposure to tobacco advertising in the last 30 days through multiple media sources...
July 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28214970/optimal-bowel-cleansing-for-colonoscopy-in-the-elderly-patient
#9
Samuel B Ho, Rita Hovsepians, Samir Gupta
Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks and benefits of colonoscopy procedures need to be carefully considered in these patients. Recent studies have shown that 4 L polyethylene glycol with a split preparation is safe and effective for elderly patients, and is the preferred preparation for patients with medical comorbidities...
March 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28167157/replacing-the-guaiac-fecal-occult-blood-test-with-the-fecal-immunochemical-test-increases-proportion-of-individuals-screened-in-a-large-healthcare-setting
#10
Ali Akram, Derek Juang, Ranier Bustamante, Lin Liu, Ashley Earles, Samuel B Ho, Jessica Wang-Rodriguez, James Allison, Samir Gupta
BACKGROUND & AIMS: The most commonly used noninvasive test for colorectal cancer (CRC) screening has been the guaiac fecal occult blood test (gFOBT). The fecal immunochemical test (FIT) detects CRC and colorectal polyps with higher levels of sensitivity than the gFOBT, and may be more acceptable to patients. However, the FIT has not replaced the gFOBT in many clinical settings. We analyzed data from a large healthcare system that replaced the gFOBT with the FIT to determine the effects on CRC screening...
February 4, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28114551/reevaluation-of-diagnosis-in-adults-with-physician-diagnosed-asthma
#11
MULTICENTER STUDY
Shawn D Aaron, Katherine L Vandemheen, J Mark FitzGerald, Martha Ainslie, Samir Gupta, Catherine Lemière, Stephen K Field, R Andrew McIvor, Paul Hernandez, Irvin Mayers, Sunita Mulpuru, Gonzalo G Alvarez, Smita Pakhale, Ranjeeta Mallick, Louis-Philippe Boulet
Importance: Although asthma is a chronic disease, the expected rate of spontaneous remissions of adult asthma and the stability of diagnosis are unknown. Objective: To determine whether a diagnosis of current asthma could be ruled out and asthma medications safely stopped in randomly selected adults with physician-diagnosed asthma. Design, Setting, and Participants: A prospective, multicenter cohort study was conducted in 10 Canadian cities from January 2012 to February 2016...
January 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28024865/taxonomy-for-colorectal-cancer-screening-promotion-lessons-from-recent-randomized-controlled-trials
#12
Paul Ritvo, Ronald E Myers, Mardie Serenity, Samir Gupta, John M Inadomi, Beverly B Green, Anthony Jerant, Jill Tinmouth, Lawrence Paszat, Meysam Pirbaglou, Linda Rabeneck
OBJECTIVE: To derive a taxonomy for colorectal cancer screening that advances Randomized Controlled Trials (RCTs) and screening uptake. DESIGN: Detailed publication review, multiple interviews with principal investigators (PIs) and collaboration with PIs as co-authors produced a CRCS intervention taxonomy. Semi-structured interview questions with PIs (Drs. Inadomi, Myers, Green, Gupta, Jerant and Ritvo) yielded details about trial conduct. Interview comparisons led to an iterative process informing serial interviews until a consensus was obtained on final taxonomy structure...
December 24, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27965125/structure-function-relationship-of-a-bio-pesticidal-trypsin-chymotrypsin-inhibitor-from-winged-bean
#13
Sayanika Banerjee, Ashok P Giri, Vidya S Gupta, Samir Kumar Dutta
Protease inhibitors are essential bio-molecules that serve as a model system for the study of protein structure and protease-protease inhibitor interaction. We here report a bi-functional serine protease inhibitor from winged bean (WBCTI) that completely retains its inhibitory property against trypsin and chymotrypsin even after heating at 70°C. Detailed circular dichroism and fluorescence studies at different temperatures, 30-90°C, have been performed to understand the reason behind thermal stability of the protein...
December 10, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27919915/chemoprevention-of-colorectal-cancer-in-individuals-with-previous-colorectal-neoplasia-systematic-review-and-network-meta-analysis
#14
REVIEW
Parambir S Dulai, Siddharth Singh, Evelyn Marquez, Rohan Khera, Larry J Prokop, Paul J Limburg, Samir Gupta, Mohammad Hassan Murad
OBJECTIVE:  To assess the comparative efficacy and safety of candidate agents (low and high dose aspirin, non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), calcium, vitamin D, folic acid, alone or in combination) for prevention of advanced metachronous neoplasia (that is, occurring at different times after resection of initial neoplasia) in individuals with previous colorectal neoplasia, through a systematic review and network meta-analysis. DATA SOURCES:  Medline, Embase, Web of Science, from inception to 15 October 2015; clinical trial registries...
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27916678/incidence-risk-factors-and-outcomes-of-colorectal-cancer-in-patients-with-ulcerative-colitis-with-low-grade-dysplasia-a-systematic-review-and-meta-analysis
#15
REVIEW
Mathurin Fumery, Parambir S Dulai, Samir Gupta, Larry J Prokop, Sonia Ramamoorthy, William J Sandborn, Siddharth Singh
BACKGROUND & AIMS: Little is known about outcomes of patients with ulcerative colitis with low-grade dysplasia (UC-LGD). We estimated the incidence of and risk factors for progression to colorectal cancer (CRC) in cohorts of patients with UC-LGD who underwent surveillance (surveillance cohort), and the prevalence of dysplasia-related findings among patients who underwent colectomy for UC-LGD (surgical cohort). METHODS: We performed a systematic literature review through June 1, 2016, to identify cohort studies of adults with UC-LGD...
December 1, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27864324/colorectal-cancer-is-a-leading-cause-of-cancer-incidence-and-mortality-among-adults-younger-than-50%C3%A2-years-in-the-usa-a-seer-based-analysis-with-comparison-to-other-young-onset-cancers
#16
Abhishek Bhandari, Melissa Woodhouse, Samir Gupta
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1...
November 18, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27862920/alternative-designs-for-clinical-trials-in-rare-diseases
#17
Lusine Abrahamyan, Brian M Feldman, George Tomlinson, Marie E Faughnan, Sindhu R Johnson, Ivan R Diamond, Samir Gupta
Evidence-based medicine requires strong scientific evidence upon which to base treatment. In rare diseases, study populations are often small, and thus this evidence is difficult to accrue. Investigators, though, should be creative and develop a flexible toolkit of methods to deal with the problems inherent in the study of rare disease. This narrative review presents alternative clinical trial designs for studying treatments of rare diseases, including cross-over and n-of-1 trials, randomized placebo-phase design, enriched enrollment, randomized withdrawal design, and classes of adaptive designs...
December 2016: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/27762527/post-partum-angiopathy-presenting-as-ischemic-stroke
#18
Pooja Gupta, Anshu Rohatgi, Samir Patel
Post-partum angiopathy is grouped within the category of reversible cerebral vasoconstriction syndromes. It is considered to be a rare but under-recognized cause of stroke especially in pregnancy. We present the case of a 24 year old female who presented with hemiparesis and seizure, and turned out to be a case of post partum angiopathy.
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27685535/influence-of-computer-generated-mosaic-photographs-on-retinopathy-of-prematurity-diagnosis-and-management
#19
Samir N Patel, Michael A Klufas, Christina E Douglas, Karyn E Jonas, Susan Ostmo, Audina Berrocal, Antonio Capone, Maria A Martinez-Castellanos, Felix Chau, Kimberly Drenser, Philip Ferrone, Anton Orlin, Irena Tsui, Wei-Chi Wu, Mrinali P Gupta, Michael F Chiang, R V Paul Chan
Importance: Telemedicine is becoming an increasingly important component of clinical care for retinopathy of prematurity (ROP), but little information exists regarding the role of mosaic photography for ROP telemedicine diagnosis. Objective: To examine the potential effect of computer-generated mosaic photographs on the diagnosis and management of ROP. Design, Setting, and Participants: In this prospective cohort study performed from July 12, 2011, through September 21, 2015, images were acquired from ROP screening at 8 academic institutions, and ROP experts interpreted 40 sets (20 sets with individual fundus photographs with ≥3 fields and 20 computer-generated mosaic photographs) of wide-angle retinal images from infants with ROP...
November 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27679553/colorectal-cancer-and-dysplasia-in-inflammatory-bowel-disease-a-review-of-disease-epidemiology-pathophysiology-and-management
#20
REVIEW
Parambir S Dulai, William J Sandborn, Samir Gupta
Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) characterized by recurrent episodes of mucosal inflammation. This chronic mucosal inflammation has several potential consequences, one of which is the occurrence of colitis-associated colorectal cancer. Over the past decade, our understanding of the epidemiology, pathophysiology, and overall approach to diagnosing and managing colitis-associated colorectal cancer has grown considerably. In the current review article, we outline these advancements and highlight areas in need of further research...
December 2016: Cancer Prevention Research
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