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Jonathan terdiman

Trilokesh D Kidambi, Gabriela Schmajuk, Andrew J Gross, James W Ostroff, Jonathan P Terdiman, Jeffrey K Lee
AIM: To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODS: A cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a ten year period was performed. Chart review was performed to confirm the diagnosis of dermatomyositis. Findings on endoscopy were collected and statistical analyses stratified by age and presence of symptoms were performed...
July 14, 2017: World Journal of Gastroenterology: WJG
Trilokesh D Kidambi, Christina Pedley, Amie Blanco, Emily K Bergsland, Jonathan P Terdiman
Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally associated with hereditary GI cancer syndromes. However, with widespread implementation of colorectal cancer screening programs, lower GI NENs are being identified with increasing frequency. We report the first case series of six patients with lower GI NENs who were diagnosed with hereditary GI cancer syndromes by germline testing. Two patients presented with poorly differentiated rectal neuroendocrine carcinoma (NECs) with colonic polyposis and were found to have Familial Adenomatous Polyposis and MYH-Associated Polyposis, respectively...
October 2017: Familial Cancer
Ana Sánchez Azofra, Trilokesh D Kidambi, Rita J Jeremy, Peggy Conrad, Amie Blanco, Megan Myers, James Barkovich, Jonathan P Terdiman
BACKGROUND: Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary colon cancer syndrome caused by mutations in adenomatous polyposis coli (APC) with both colonic and extra-colonic manifestations. Case reports have noted an association with FAP and intellectual disability and animal studies have shown that APC is implicated in neural development and function, but no studies have investigated neuropsychological, behavioral, or structural brain characteristics of patients with FAP...
2016: Hereditary Cancer in Clinical Practice
Trilokesh D Kidambi, Robin Lee, Jonathan P Terdiman, Lukejohn Day
Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC), and national guidelines recommend screening patients with CRC for LS. However, there is a paucity of data related to Lynch syndrome in the underserved population, in which unique issues of access, cultural beliefs regarding cancer, language barriers, immigration status, and financial restraints exist. We performed a descriptive, retrospective review of a selective LS screening protocol at an urban safety net hospital between 2009 and 2014 with the aim of describing the detected prevalence of LS as well as reporting the high quality and suboptimal screening rates...
July 2016: Journal of Community Genetics
Trilokesh D Kidambi, Amie Blanco, Jessica Van Ziffle, Jonathan P Terdiman
At least one-third of patients meeting clinical criteria for Lynch syndrome will have no germline mutation and constitutional epimutations leading to promoter methylation of MLH1 have been identified in a subset of these patients. We report the first case of constitutional MLH1 promoter methylation associated with a colonic polyposis syndrome in a 39 year-old man with a family history of colorectal cancer (CRC) and a personal history of 21 polyps identified over 8 years as well as the development of two synchronous CRCs over 16 months who was evaluated for a hereditary cancer syndrome...
April 2016: Familial Cancer
Rodrigo Santa Cruz Guindalini, Aung Ko Win, Cassandra Gulden, Noralane M Lindor, Polly A Newcomb, Robert W Haile, Victoria Raymond, Elena Stoffel, Michael Hall, Xavier Llor, Chinedu I Ukaegbu, Ilana Solomon, Jeffrey Weitzel, Matthew Kalady, Amie Blanco, Jonathan Terdiman, Gladis A Shuttlesworth, Patrick M Lynch, Heather Hampel, Henry T Lynch, Mark A Jenkins, Olufunmilayo I Olopade, Sonia S Kupfer
BACKGROUND & AIMS: African Americans (AAs) have the highest incidence of and mortality resulting from colorectal cancer (CRC) in the United States. Few data are available on genetic and nongenetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in mismatch repair (MMR) genes in AAs with the most common inherited CRC condition, Lynch syndrome. We aimed to characterize phenotype, mutation spectrum, and risk of CRC in AAs with Lynch syndrome. METHODS: We performed a retrospective study of AAs with mutations in MMR genes (MLH1, MSH2, MSH6, and PMS2) using databases from 13 US referral centers...
November 2015: Gastroenterology
Chanda K Ho, Christy K Boscardin, Nathaniel Gleason, Don Collado, Jonathan Terdiman, Norah A Terrault, Ralph Gonzales
RATIONALE, AIMS AND OBJECTIVES: Specialty care referrals have doubled in the last decade. Optimization of the pre-referral workup by a primary care doctor can lead to a more efficient first specialty visit with the patient. Guidance regarding pre-referral laboratory testing is a first step towards improving the specialty referral process. Our aim was to establish consensus regarding appropriate pre-referral workup for common gastrointestinal and liver conditions. METHODS: The Delphi method was used to establish local consensus for recommending certain laboratory tests prior to specialty referral for 13 clinical conditions...
February 2016: Journal of Evaluation in Clinical Practice
McKinsey L Goodenberger, Brittany C Thomas, Douglas Riegert-Johnson, C Richard Boland, Sharon E Plon, Mark Clendenning, Aung Ko Win, Leigha Senter, Steven M Lipkin, Zsofia K Stadler, Finlay A Macrae, Henry T Lynch, Jeffrey N Weitzel, Albert de la Chapelle, Sapna Syngal, Patrick Lynch, Susan Parry, Mark A Jenkins, Steven Gallinger, Spring Holter, Melyssa Aronson, Polly A Newcomb, Terrilea Burnett, Loïc Le Marchand, Pavel Pichurin, Heather Hampel, Jonathan P Terdiman, Karen H Lu, Stephen Thibodeau, Noralane M Lindor
Germ-line mutations in MLH1, MSH2, MSH6, and PMS2 have been shown to cause Lynch syndrome. The penetrance of the cancer and tumor spectrum has been repeatedly studied, and multiple professional societies have proposed clinical management guidelines for affected individuals. Several studies have demonstrated a reduced penetrance for monoallelic carriers of PMS2 mutations compared with the other mismatch repair (MMR) genes, but clinical management guidelines have largely proposed the same screening recommendations for all MMR gene carriers...
January 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Trilokesh D Kidambi, Amie Blanco, Megan Myers, Peggy Conrad, Kate Loranger, Jonathan P Terdiman
BACKGROUND: Lynch syndrome is the most common cause of hereditary colorectal cancer (CRC) and confers increased risk of other cancers. Identification of patients improves morbidity and mortality. Screening tumors for absent mismatch repair (MMR) protein expression by immunohistochemistry (IHC) is a recommended approach. Despite guidelines advocating universal screening, significant variation in clinical practice exists. AIMS/METHODS: A retrospective study of two different IHC-based Lynch syndrome screening protocols at an urban, university hospital was performed...
August 2015: Digestive Diseases and Sciences
Shailja Shah, Jonathan Terdiman, Katherine Gundling, Uma Mahadevan
No abstract text is available yet for this article.
March 2014: Therapeutic Advances in Gastroenterology
Randall W Burt, Jamie A Cannon, Donald S David, Dayna S Early, James M Ford, Francis M Giardiello, Amy L Halverson, Stanley R Hamilton, Heather Hampel, Mohammad K Ismail, Kory Jasperson, Jason B Klapman, Audrey J Lazenby, Patrick M Lynch, Robert J Mayer, Reid M Ness, Dawn Provenzale, M Sambasiva Rao, Moshe Shike, Gideon Steinbach, Jonathan P Terdiman, David Weinberg, Mary Dwyer, Deborah Freedman-Cass
Mortality from colorectal cancer can be reduced by early diagnosis and by cancer prevention through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe various colorectal screening modalities and recommended screening schedules for patients at average or increased risk of developing colorectal cancer. In addition, the guidelines provide recommendations for the management of patients with high-risk colorectal cancer syndromes, including Lynch syndrome. Screening approaches for Lynch syndrome are also described...
December 1, 2013: Journal of the National Comprehensive Cancer Network: JNCCN
Jonathan P Terdiman, Claudia B Gruss, Joel J Heidelbaugh, Shahnaz Sultan, Yngve T Falck-Ytter
No abstract text is available yet for this article.
December 2013: Gastroenterology
Brindusa Truta, Dan X Li, Uma Mahadevan, Elena R Fisher, Yunn-Y Chen, Kim Grace, Fernando Velayos, Jonathan P Terdiman
BACKGROUND AND AIMS: One of the causes of pouch failure after ileal pouch anal anastomosis (IPAA) for ulcerative colitis (UC) is the development of de novo Crohn's disease (CD). Our aim was to clearly define factors associated with post-IPAA CD. METHODS: We conducted a cross-sectional study to compare demographic, clinical, and serological characteristics of patients with and without post-IPAA CD. All subjects underwent testing for anti-neutrophil cytoplasm antibodies, anti-Saccaromyces cerevisiae antibodies, anti-outer membrane porin C antibodies, and anti-CBir1 flagellin (anti-CBir1)...
January 2014: Digestive Diseases and Sciences
Matthew B Yurgelun, Rowena Mercado, Margery Rosenblatt, Monica Dandapani, Wendy Kohlmann, Peggy Conrad, Amie Blanco, Kristen M Shannon, Daniel C Chung, Jonathan Terdiman, Stephen B Gruber, Judy E Garber, Sapna Syngal, Elena M Stoffel
OBJECTIVE: Due to the increased lifetime risk of endometrial cancer (EC), guidelines recommend that women with Lynch syndrome (LS) age ≥ 35 undergo annual EC surveillance or prophylactic hysterectomy (PH). The aim of this study was to examine the uptake of these risk-reducing strategies. METHODS: The study population included women meeting clinical criteria for genetic evaluation for LS. Data on cancer risk-reducing behaviors were collected from subjects enrolled in two distinct studies: (1) a multicenter cross-sectional study involving completion of a one-time questionnaire, or (2) a single-center longitudinal study in which subjects completed questionnaires before and after undergoing genetic testing...
December 2012: Gynecologic Oncology
Miriam Kuppermann, Grace Wang, Shirley Wong, Amie Blanco, Peggy Conrad, Sanae Nakagawa, Jonathan Terdiman, Uri Ladabaum
BACKGROUND: Current guidelines recommend offering genetic testing for Lynch syndrome to individuals whose tumors suggest this condition and to relatives of affected individuals. Little is known, however, regarding how patients view the prospect of such testing. In addition, data on preferences (utilities) for the potential outcomes of testing decisions for use in cost-effectiveness analyses are lacking. METHODS: Time tradeoff utilities were elicited for 10 potential outcomes of Lynch syndrome testing decisions and 3 associated cancers from 70 participants, representing a range of knowledge about and experiences with Lynch syndrome...
January 1, 2013: Cancer
Lior Katz, Javier P Gisbert, Beth Manoogian, Kirk Lin, Casper Steenholdt, Gerassimos J Mantzaris, Ashish Atreja, Yulia Ron, Arun Swaminath, Somal Shah, Ailsa Hart, Peter Laszlo Lakatos, Pierre Ellul, Eran Israeli, Mads Naundrup Svendsen, C Janneke van der Woude, Konstantinos H Katsanos, Laura Yun, Epameinondas V Tsianos, Torben Nathan, Maria Abreu, Iris Dotan, Bret Lashner, Jorn Brynskov, Jonathan P Terdiman, Peter D R Higgins, Maria Chaparro, Shomron Ben-Horin
BACKGROUND: Intensifying infliximab therapy is often practiced in Crohn's disease (CD) patients losing response to the drug but there are no data if halving the interval is superior to doubling the dose. We aimed to assess the efficacy of infliximab dose intensification by interval-halving compared with dose-doubling. METHODS: A multicenter retrospective study of CD patients losing response to infliximab was undertaken. The clinical outcome of patients whose infusion intervals were halved (5 mg/kg/4 weeks) was compared with patients treated by dose-doubling (10 mg/kg/8 weeks)...
November 2012: Inflammatory Bowel Diseases
Michael Larsen, Nancy Hills, Jonathan Terdiman
OBJECTIVES: Published guidelines for timing of follow-up colonoscopy assume that the entire colon mucosa is visualized and provide no guidance in the case of poor preparations. We aimed to determine how preparation quality during screening colonoscopy affects gastroenterologists' recommendations on the timing of follow-up colonoscopy. METHODS: Gastroenterologists were shown representative images of four colonoscopies with differing colon-preparation quality. For each set of images they were asked to recommend when a hypothetical patient with no polyps or malignancy on screening examination should return for a subsequent colonoscopy...
December 2011: American Journal of Gastroenterology
Kirk K Lin, Fernando Velayos, Elena Fisher, Jonathan P Terdiman
BACKGROUND: Dose intensification is a common approach to treat Crohn's disease (CD) patients who lose response to infliximab maintenance therapy. Few studies have reported upon its long-term efficacy or predictors of response. AIM: The goal of this study is to investigate durability and predictors of response to dose intensification-including method of dose intensification, combination immunomodulator therapy, and premedication with intravenous hydrocortisone. METHODS: We performed a retrospective study of dose-intensified CD patients at our institution...
April 2012: Digestive Diseases and Sciences
Uri Ladabaum, Grace Wang, Jonathan Terdiman, Amie Blanco, Miriam Kuppermann, C Richard Boland, James Ford, Elena Elkin, Kathryn A Phillips
BACKGROUND: Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine. OBJECTIVE: To estimate the effectiveness and cost-effectiveness of strategies to identify the Lynch syndrome, with attention to sex, age at screening, and differential effects for probands and relatives. DESIGN: Markov model that incorporated risk for colorectal, endometrial, and ovarian cancers...
July 19, 2011: Annals of Internal Medicine
Omar Khan, Amie Blanco, Peggy Conrad, Cassandra Gulden, Tovah Z Moss, Olufunmilayo I Olopade, Sonia S Kupfer, Jonathan Terdiman
OBJECTIVES: Lynch syndrome is the most common cause of inherited colorectal cancer (CRC) and is due to germline mutations in mismatch repair (MMR) genes. Early Lynch syndrome diagnosis and appropriate CRC surveillance improves mortality. Traditional qualitative clinical criteria including Amsterdam and Bethesda guidelines may miss mutation carriers. Recently, quantitative predictive models including MMRPredict, PREMM(1,2,6), and MMRPro were developed to facilitate diagnosis. However, these models remain to be externally validated in the United States...
October 2011: American Journal of Gastroenterology
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