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Ikuo hirano

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https://www.readbyqxmd.com/read/27920250/renal-anemia-model-mouse-established-by-transgenic-rescue-with-erythropoietin-gene-lacking-kidney-specific-regulatory-elements
#1
Ikuo Hirano, Norio Suzuki, Shun Yamazaki, Hiroki Sekine, Naoko Minegishi, Ritsuko Shimizu, Masayuki Yamamoto
The erythropoietin (Epo) gene is under tissue-specific inducible regulation. Because kidney is the primary EPO-producing tissue in adults, impaired EPO production in chronic kidney disorders results in serious renal anemia. The Epo gene contains a liver-specific enhancer in the 3' region, but the kidney-specific enhancer for gene expression in renal EPO-producing (REP) cells remains elusive. Here, we examined a Conserved-Upstream-element for Renal-Epo-regulation (CURE) region that spans 17.4 kb to 3.6 kb upstream of the Epo gene and harbors several phylogenetically conserved elements...
December 5, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27889574/budesonide-oral-suspension-improves-symptomatic-endoscopic-and-histologic-parameters-compared-with-placebo-in-patients-with-eosinophilic-esophagitis
#2
Evan S Dellon, David A Katzka, Margaret H Collins, Mohamed Hamdani, Sandeep K Gupta, Ikuo Hirano
BACKGROUND & AIMS: Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE. METHODS: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group trial, 93 EoE patients between the ages of 11 and 40 years with dysphagia and active esophageal eosinophilia were randomized to receive either BOS 2 mg or placebo twice daily for 12 weeks...
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27845336/how-i-approach-the-management-of-eosinophilic-esophagitis-in-adults
#3
Ikuo Hirano
No abstract text is available yet for this article.
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27725650/evaluation-of-esophageal-motility-utilizing-the-functional-lumen-imaging-probe
#4
Dustin A Carlson, Peter J Kahrilas, Zhiyue Lin, Ikuo Hirano, Nirmala Gonsalves, Zoe Listernick, Katherine Ritter, Michael Tye, Fraukje A Ponds, Ian Wong, John E Pandolfino
OBJECTIVES: Esophagogastric junction (EGJ) distensibility and distension-mediated peristalsis can be assessed with the functional lumen imaging probe (FLIP) during a sedated upper endoscopy. We aimed to describe esophageal motility assessment using FLIP topography in patients presenting with dysphagia. METHODS: In all, 145 patients (aged 18-85 years, 54% female) with dysphagia that completed upper endoscopy with a 16-cm FLIP assembly and high-resolution manometry (HRM) were included...
October 11, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27206583/narrow-caliber-esophagus-of-eosinophilic-esophagitis-difficult-to-define-resistant-to-remedy
#5
EDITORIAL
Dustin A Carlson, Ikuo Hirano
No abstract text is available yet for this article.
June 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27200524/severity-of-endoscopically-identified-esophageal-rings-correlates-with-reduced-esophageal-distensibility-in-eosinophilic-esophagitis
#6
Joan W Chen, John E Pandolfino, Zhiyue Lin, Jody D Ciolino, Nirmala Gonsalves, Peter J Kahrilas, Ikuo Hirano
BACKGROUND/AIMS: A grading system for the endoscopic features of eosinophilic esophagitis (EoE) has recently been validated. The EoE Endoscopic Reference Score (EREFS) incorporates both inflammatory and remodeling features of EoE. High resolution impedance planimetry using the functional luminal imaging probe (FLIP) is a technique for quantification of esophageal remodeling. The aim of this study was to evaluate the association between endoscopic severity with EREFS and esophageal distensibility as measured with the FLIP...
September 2016: Endoscopy
https://www.readbyqxmd.com/read/27155108/diagnosis-and-treatment-of-eosinophilic-esophagitis-in-adults
#7
REVIEW
Robert T Kavitt, Ikuo Hirano, Michael F Vaezi
Eosinophilic esophagitis is a relatively recently discovered disease of increasing incidence and prevalence and is a common cause of dysphagia and food bolus impaction. The definition of eosinophilic esophagitis continues to evolve, most recently with the characterization of proton pump inhibitor-responsive esophageal eosinophilia. The number of high-quality prospective, controlled trials guiding therapeutic decisions in eosinophilic esophagitis has increased steadily over the past several years. Treatment options at present focus on dietary therapy, particularly implementation of a 6-food elimination diet, and medical therapy, primarily the use of swallowed, topical corticosteroids...
September 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27112108/substantial-variability-in-biopsy-practice-patterns-among-gastroenterologists-for-suspected-eosinophilic-gastrointestinal-disorders
#8
LETTER
Evan S Dellon, Margaret H Collins, Peter A Bonis, John Leung, Kelley E Capocelli, Ranjan Dohil, Gary W Falk, Glenn T Furuta, Calies Menard-Katcher, Sandeep K Gupta, Ikuo Hirano, Girish S Hiremath, Amir F Kagalwalla, Barry K Wershil, Chris A Liacouras, Amanda B Muir, Vincent A Mukkada, Philip E Putnam, Alain M Schoepfer, Alex Straumann, John M Wo, Guang-Yu Yang, Marc E Rothenberg, Nirmala Gonsalves
No abstract text is available yet for this article.
December 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27068720/2015-david-y-graham-lecture-the-first-two-decades-of-eosinophilic-esophagitis-from-acid-reflux-to-food-allergy
#9
REVIEW
Ikuo Hirano
Collaborative efforts by pediatric and adult gastroenterologists, allergists, dieticians, and pathologists have brought about marked progress in the recognition, understanding, and management of eosinophilic esophagitis (EoE) over the past two decades. Once an esoteric diagnosis, EoE is now increasingly identified as a major cause of morbidity, afflicting both children and adults. The detection of mucosal eosinophils has evolved from a diagnostic feature of acid reflux to a biomarker of food sensitization of the esophagus...
June 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27054896/advances-in-the-endoscopic-evaluation-of-eosinophilic-esophagitis
#10
Leila Kia, Ikuo Hirano
PURPOSE OF REVIEW: Endoscopic detection of mucosal healing has emerged as a primary therapeutic endpoint in inflammatory bowel disease. Endoscopically identified esophageal features are increasingly being utilized in diagnostic and therapeutic decisions in eosinophilic esophagitis (EoE). RECENT FINDINGS: Studies over the past 5 years have demonstrated the validity, accuracy, and clinical relevance of a systematic, endoscopic assessment of esophageal abnormalities in EoE...
July 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27032682/diversity-of-lipid-distribution-in-fish-skeletal-muscle
#11
Gen Kaneko, Hirohito Shirakami, Yuki Hirano, Moemi Oba, Hazuki Yoshinaga, Anurak Khieokhajonkhet, Reiko Nagasaka, Hidehiro Kondo, Ikuo Hirono, Hideki Ushio
Adipose tissue is a lipid storage organ characterized by the pronounced accumulation of adipocytes. Although adipose tissues are found in various parts of the vertebrate body, it is unclear whether these tissues have a common ancestral origin or have evolved in several phylogenetic lineages by independent adipocyte accumulation events. To gain insight into the evolutionary history of vertebrate adipose tissues, we determined the distribution of adipocytes by oil red O staining in skeletal muscle of 10 teleost species spanning eight orders: Tetraodontiformes, Pleuronectiformes, Spariformes, Salmoniformes, Clupeiformes, Beloniformes, Osmeriformes, and Cypriniformes...
April 2016: Zoological Science
https://www.readbyqxmd.com/read/26725190/should-wheat-barley-rye-and-or-gluten-be-avoided-in-a-6-food-elimination-diet
#12
Kara L Kliewer, Carina Venter, Alison M Cassin, J Pablo Abonia, Seema S Aceves, Peter A Bonis, Evan S Dellon, Gary W Falk, Glenn T Furuta, Nirmala Gonsalves, Sandeep K Gupta, Ikuo Hirano, Amir Kagalwalla, John Leung, Vincent A Mukkada, Jonathan M Spergel, Marc E Rothenberg
Eosinophilic esophagitis (EoE), a food antigen-mediated disease, is effectively treated with the dietary elimination of 6 foods commonly associated with food allergies (milk, wheat, egg, soy, tree nuts/peanuts, and fish/shellfish). Because wheat shares homologous proteins (including gluten) with barley and rye and can also be processed with these grains, some clinicians have suggested that barley and rye might also trigger EoE as a result of cross-reaction and/or cross-contamination with wheat. In this article, we discuss the theoretical risks of cross-reactivity and cross-contamination among wheat, barley, and rye proteins (including gluten); assess common practices at EoE treatment centers; and provide recommendations for dietary treatment and future studies of EoE...
April 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26685124/proton-pump-inhibitor-responsive-oesophageal-eosinophilia-an-entity-challenging-current-diagnostic-criteria-for-eosinophilic-oesophagitis
#13
Javier Molina-Infante, Albert J Bredenoord, Edaire Cheng, Evan S Dellon, Glenn T Furuta, Sandeep K Gupta, Ikuo Hirano, David A Katzka, Fouad J Moawad, Marc E Rothenberg, Alain Schoepfer, Stuart J Spechler, Ting Wen, Alex Straumann, Alfredo J Lucendo
Consensus diagnostic recommendations to distinguish GORD from eosinophilic oesophagitis (EoE) by response to a trial of proton pump inhibitors (PPIs) unexpectedly uncovered an entity called 'PPI-responsive oesophageal eosinophilia' (PPI-REE). PPI-REE refers to patients with clinical and histological features of EoE that remit with PPI treatment. Recent and evolving evidence, mostly from adults, shows that patients with PPI-REE and patients with EoE at baseline are clinically, endoscopically and histologically indistinguishable and have a significant overlap in terms of features of Th2 immune-mediated inflammation and gene expression...
March 2016: Gut
https://www.readbyqxmd.com/read/26584601/symptoms-have-modest-accuracy-in-detecting-endoscopic-and-histologic-remission-in-adults-with-eosinophilic-esophagitis
#14
MULTICENTER STUDY
Ekaterina Safroneeva, Alex Straumann, Michael Coslovsky, Marcel Zwahlen, Claudia E Kuehni, Radoslaw Panczak, Nadine A Haas, Jeffrey A Alexander, Evan S Dellon, Nirmala Gonsalves, Ikuo Hirano, John Leung, Christian Bussmann, Margaret H Collins, Robert O Newbury, Giovanni De Petris, Thomas C Smyrk, John T Woosley, Pu Yan, Guang-Yu Yang, Yvonne Romero, David A Katzka, Glenn T Furuta, Sandeep K Gupta, Seema S Aceves, Mirna Chehade, Jonathan M Spergel, Alain M Schoepfer
BACKGROUND & AIMS: It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. METHODS: Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States...
March 2016: Gastroenterology
https://www.readbyqxmd.com/read/26582459/s6-kinase-phosphorylated-at-t229-is-involved-in-tau-and-actin-pathologies-in-alzheimer-s-disease
#15
Yuma Sonoda, Ikuo Tooyama, Hideyuki Mukai, Kiyoshi Maeda, Haruhiko Akiyama, Toshio Kawamata
The 70-kDa ribosomal protein S6 kinase (S6K), a serine/threonine kinase that modulates the phosphorylation of the 40S ribosomal protein S6, regulates cell cycle progression and is known as a tau kinase in Alzheimer's disease (AD). In AD brains, neurofibrillary tangles (NFTs) have been shown to be positively stained with antibodies against S6K proteins phosphorylated at T389 (pT389-S6K) or T421/S424 (pT421/S424-S6K) by the mammalian target of rapamycin and mitogen-activated protein kinase pathways, respectively...
August 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/26552781/therapeutic-strategies-in-eosinophilic-esophagitis-induction-maintenance-and-refractory-disease
#16
REVIEW
Jamie Sodikoff, Ikuo Hirano
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease that is increasingly recognized as one of the most common causes of dysphagia and foregut symptoms in adults and children. Topical corticosteroids, elimination diets, and esophageal dilations are effective options for both induction and maintenance therapy in EoE. Current pharmacologic options are being used off-label as no agent has yet been approved by regulatory authorities. Little is known about the natural history of EoE, however, raising controversy regarding the necessity of maintenance and therapy in asymptomatic or treatment-refractory patients...
October 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26552768/eosinophilic-esophagitis-preface
#17
Albert J Bredenoord, Ikuo Hirano
No abstract text is available yet for this article.
October 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26453777/american-gastroenterological-association-institute-guideline-on-the-management-of-acute-diverticulitis
#18
Neil Stollman, Walter Smalley, Ikuo Hirano
No abstract text is available yet for this article.
December 2015: Gastroenterology
https://www.readbyqxmd.com/read/26318073/proton-pump-inhibitor-responsive-esophageal-eosinophilia-does-not-preclude-food-responsive-eosinophilic-esophagitis
#19
LETTER
Jamie Sodikoff, Ikuo Hirano
No abstract text is available yet for this article.
February 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26220546/molecular-characterization-of-systemic-sclerosis-esophageal-pathology-identifies-inflammatory-and-proliferative-signatures
#20
Jaclyn N Taroni, Viktor Martyanov, Chiang-Ching Huang, J Matthew Mahoney, Ikuo Hirano, Brandon Shetuni, Guang-Yu Yang, Darren Brenner, Barbara Jung, Tammara A Wood, Swati Bhattacharyya, Orit Almagor, Jungwha Lee, Arlene Sirajuddin, John Varga, Rowland W Chang, Michael L Whitfield, Monique Hinchcliff
INTRODUCTION: Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no animal scleroderma esophagus models and esophageal smooth muscle cells dedifferentiate in culture prohibiting in vitro studies. Esophageal fibrosis is thought to disrupt smooth muscle function and lead to esophageal dilatation, but autopsy studies demonstrate esophageal smooth muscle atrophy and the absence of fibrosis in the majority of SSc cases...
2015: Arthritis Research & Therapy
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