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John pandolfino

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https://www.readbyqxmd.com/read/27725650/evaluation-of-esophageal-motility-utilizing-the-functional-lumen-imaging-probe
#1
Dustin A Carlson, Peter J Kahrilas, Zhiyue Lin, Ikuo Hirano, Nirmala Gonsalves, Zoe Listernick, Katherine Ritter, Michael Tye, Fraukje A Ponds, Ian Wong, John E Pandolfino
OBJECTIVES: Esophagogastric junction (EGJ) distensibility and distension-mediated peristalsis can be assessed with the functional lumen imaging probe (FLIP) during a sedated upper endoscopy. We aimed to describe esophageal motility assessment using FLIP topography in patients presenting with dysphagia. METHODS: In all, 145 patients (aged 18-85 years, 54% female) with dysphagia that completed upper endoscopy with a 16-cm FLIP assembly and high-resolution manometry (HRM) were included...
October 11, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27698386/high-resolution-impedance-manometry-metrics-of-the-esophagogastric-junction-for-the-assessment-of-treatment-response-in-achalasia
#2
Dustin A Carlson, Zhiyue Lin, Peter J Kahrilas, Joel Sternbach, Eric S Hungness, Nathaniel J Soper, Michelle Balla, Zoe Listernick, Michael Tye, Katherine Ritter, Jenna Craft, Jody D Ciolino, John E Pandolfino
OBJECTIVES: We aimed to evaluate the value of novel high-resolution impedance manometry (HRIM) metrics, bolus flow time (BFT), and esophagogastric junction (EGJ) contractile integral (CI), as well as EGJ pressure (EGJP) and the integrated relaxation pressure (IRP), as indicators of treatment response in achalasia. METHODS: We prospectively evaluated 75 patients (ages 19-81, 32 female) with achalasia during follow-up after pneumatic dilation or myotomy with Eckardt score (ES), timed-barium esophagram (TBE), and HRIM...
October 4, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27581064/incidence-and-prevalence-of-achalasia-in-central-chicago-2004-2014-since-the-widespread-use-of-high-resolution-manometry
#3
Salih Samo, Dustin A Carlson, Dyanna L Gregory, Susan H Gawel, John E Pandolfino, Peter J Kahrilas
BACKGROUND & AIMS: Reported global incidence and prevalence values for achalasia vary widely, from 0.03 to 1.63 per 100,000 persons per year and from 1.8 to 12.6 per 100,000 persons per year, respectively. This study aimed to reconcile these low values with findings from a major referral center, in central Chicago (which began using high-resolution manometry in 2004 and used in it all clinical studies since 2005), and has determined the incidence and prevalence of achalasia to be much greater...
August 28, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27513156/per-oral-endoscopic-myotomy-poem-after-the-learning-curve-durable-long-term-results-with-a-low-complication-rate
#4
Eric S Hungness, Joel M Sternbach, Ezra N Teitelbaum, Peter J Kahrilas, John E Pandolfino, Nathaniel J Soper
OBJECTIVE: We aimed to report long-term outcomes for patients undergoing per-oral endoscopic myotomy (POEM) after our initial 15-case learning curve. BACKGROUND: POEM has become an established, natural-orifice surgical approach for treating esophageal motility disorders. To date, published outcomes and comparative-effectiveness studies have included patients from the early POEM experience. METHODS: Consecutive patients undergoing POEM after our initial 15 cases, with a minimum of 1-year postoperative follow-up, were included...
September 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27473627/a-system-to-assess-the-competency-for-interpretation-of-esophageal-manometry-identifies-variation-in-learning-curves
#5
Rena Yadlapati, Rajesh N Keswani, Jody D Ciolino, David P Grande, Zoe I Listernick, Dustin A Carlson, Donald O Castell, Kerry B Dunbar, Andrew J Gawron, C Prakash Gyawali, Philip O Katz, David Katzka, Brian E Lacy, Stuart J Spechler, Roger Tatum, Marcelo F Vela, John E Pandolfino
BACKGROUND & AIMS: Quality esophageal high-resolution manometry (HRM) studies require competent interpretation of data. However, there is little understanding of learning curves, training requirements, or measures of competency for HRM. We aimed to develop and use a competency assessment system to examine learning curves for interpretation of HRM data. METHODS: We conducted a prospective multicenter study of 20 gastroenterology trainees with no experience in HRM, from 8 centers, over an 8-month period (May through December 2015)...
July 27, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27337985/complications-of-botulinum-toxin-injections-for-treatment-of-esophageal-motility-disorders%C3%A2
#6
Froukje B van Hoeij, Jan F Tack, John E Pandolfino, Joel M Sternbach, Sabine Roman, André J P M Smout, Albert J Bredenoord
In achalasia and spastic esophageal motility disorders, botulinum toxin (botox) injection is considered an effective and low-risk procedure for short-term symptom relief. It is mainly offered to medically high-risk patients. However, no analysis of risks of botox injections has been performed. To determine the incidence and risk factors of procedure-related complications after esophageal botox injections, we analyzed the records of all patients undergoing botox injection therapy for esophageal motility disorders at four university hospitals in Europe and North America between 2008 and 2014...
June 24, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27261337/asia-pacific-consensus-on-the-management-of-gastro-oesophageal-reflux-disease-an-update-focusing-on-refractory-reflux-disease-and-barrett-s-oesophagus
#7
Kwong Ming Fock, Nicholas Talley, Khean Lee Goh, Kentaro Sugano, Peter Katelaris, Gerald Holtmann, John E Pandolfino, Prateek Sharma, Tiing Leong Ang, Michio Hongo, Justin Wu, Minhu Chen, Myung-Gyu Choi, Ngai Moh Law, Bor-Shyang Sheu, Jun Zhang, Khek Yu Ho, Jose Sollano, Abdul Aziz Rani, Chomsri Kositchaiwat, Shobna Bhatia
OBJECTIVE: Since the publication of the Asia-Pacific consensus on gastro-oesophageal reflux disease in 2008, there has been further scientific advancement in this field. This updated consensus focuses on proton pump inhibitor-refractory reflux disease and Barrett's oesophagus. METHODS: A steering committee identified three areas to address: (1) burden of disease and diagnosis of reflux disease; (2) proton pump inhibitor-refractory reflux disease; (3) Barrett's oesophagus...
September 2016: Gut
https://www.readbyqxmd.com/read/27240901/introduction-to-clinical-practice-update-committee-articles
#8
David A Katzka, Lawrence S Friedman, John M Inadomi, Anthony M Kalloo, Lawrence S Kim, Johannes Koch, David Lieberman, Gary R Lichtenstein, Joseph K Lim, John E Pandolfino, Andrea S Shin, Madelin R Siedler
No abstract text is available yet for this article.
July 2016: Gastroenterology
https://www.readbyqxmd.com/read/27200524/severity-of-endoscopically-identified-esophageal-rings-correlates-with-reduced-esophageal-distensibility-in-eosinophilic-esophagitis
#9
Joan W Chen, John E Pandolfino, Zhiyue Lin, Jody D Ciolino, Nirmala Gonsalves, Peter J Kahrilas, Ikuo Hirano
BACKGROUND/AIMS: A grading system for the endoscopic features of eosinophilic esophagitis (EoE) has recently been validated. The EoE Endoscopic Reference Score (EREFS) incorporates both inflammatory and remodeling features of EoE. High resolution impedance planimetry using the functional luminal imaging probe (FLIP) is a technique for quantification of esophageal remodeling. The aim of this study was to evaluate the association between endoscopic severity with EREFS and esophageal distensibility as measured with the FLIP...
September 2016: Endoscopy
https://www.readbyqxmd.com/read/27144625/functional-esophageal-disorders
#10
Qasim Aziz, Ronnie Fass, C Prakash Gyawali, Hiroto Miwa, John E Pandolfino, Frank Zerbib
Functional esophageal disorders consist of a disease category that present with esophageal symptoms (heartburn, chest pain, dysphagia, globus) not explained by mechanical obstruction (stricture, tumor, eosinophilic esophagitis), major motor disorders (achalasia, EGJ outflow obstruction, absent contractility, distal esophageal spasm, jackhammer esophagus), or gastroesophageal reflux disease (GERD). While mechanisms responsible are unclear, it is theorized that visceral hypersensitivity and hypervigilance play an important role in symptom generation, in the context of normal or borderline function...
February 15, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27134603/the-use-of-endoscopy-and-radiofrequency-ablation-for-the-treatment-of-gerd
#11
John E Pandolfino
No abstract text is available yet for this article.
December 2015: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27118931/high-resolution-manometry-in-clinical-practice
#12
Dustin A Carlson, John E Pandolfino
High-resolution manometry (HRM) is the primary method used to evaluate esophageal motor function. Displayed and interpreted by esophageal pressure topography (EPT), HRM/ EPT provides a detailed assessment of esophageal function that is useful in the evaluation of patients with nonobstructive dysphagia and before foregut surgery. Esophageal motility diagnoses are determined systematically by applying objective metrics of esophageal sphincter and peristaltic function to the Chicago Classification of esophageal motility disorders...
June 2015: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27091320/oropharyngeal-ph-testing-does-not-predict-response-to-proton-pump-inhibitor-therapy-in-patients-with-laryngeal-symptoms
#13
Rena Yadlapati, John E Pandolfino, Alcina K Lidder, Nadine Shabeeb, Diana-Marie Jaiyeola, Christopher Adkins, Neelima Agrawal, Andrew Cooper, Caroline P E Price, Jody D Ciolino, Andrew J Gawron, Stephanie S Smith, Michiel Bove, Bruce K Tan
OBJECTIVES: Predicting response to proton pump inhibitor (PPI) therapy in patients with laryngeal symptoms is challenging. The Restech Dx-pH probe is a transnasal catheter that measures oropharyngeal pH. In this study, we aimed to investigate the prognostic potential of oropharyngeal pH monitoring to predict responsiveness to PPI therapy in patients with laryngeal symptoms. METHODS: We conducted a physician-blinded prospective cohort study at a single academic institution between January 2013 and October 2014...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27062902/loss-of-peristaltic-reserve-determined-by-multiple-rapid-swallows-is-the-most-frequent-esophageal-motility-abnormality-in-patients-with-systemic-sclerosis
#14
Dustin A Carlson, Michael D Crowell, Jessica N Kimmel, Amit Patel, C Prakash Gyawali, Monique Hinchcliff, W Leroy Griffing, John E Pandolfino, Marcelo F Vela
We assessed peristaltic reserve using multiple rapid swallows (MRS) during esophageal high-resolution manometry (HRM) of 111 patients with systemic sclerosis (89 women; ages, 42-64 y). We performed a retrospective analysis of HRM studies that included MRS in patients with systemic sclerosis, performed at 2 tertiary referral centers, and compared data with those from 18 healthy volunteers (controls). HRM findings were analyzed according to the Chicago Classification to provide an esophageal motility diagnosis...
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26881974/development-of-the-northwestern-esophageal-quality-of-life-scale-a-hybrid-measure-for-use-across-esophageal-conditions
#15
Alyse Bedell, Tiffany H Taft, Laurie Keefer, John Pandolfino
OBJECTIVES: Measures of health-related quality of life (HRQOL) in chronic esophageal conditions such as gastroesophageal reflux disease, eosinophilic esophagitis, and achalasia are widely used to measure this important patient-reported outcome. We seek to leverage these existing measures to create a hybrid measure of esophageal illness HRQOL (the Northwestern Esophageal Quality of Life-NEQOL), allowing for broad use across diseases while maintaining sensitivity to nuances of a specific condition...
April 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26866393/novel-tools-biomarkers-and-disease-entities-in-esophageal-disorders
#16
Rena Yadlapati, John E Pandolfino
No abstract text is available yet for this article.
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/26689899/abilities-of-oropharyngeal-ph-tests-and-salivary-pepsin-analysis-to-discriminate-between-asymptomatic-volunteers-and-subjects-with-symptoms-of-laryngeal-irritation
#17
Rena Yadlapati, Christopher Adkins, Diana-Marie Jaiyeola, Alcina K Lidder, Andrew J Gawron, Bruce K Tan, Nadine Shabeeb, Caroline P E Price, Neelima Agrawal, Michael Ellenbogen, Stephanie S Smith, Michiel Bove, John E Pandolfino
BACKGROUND & AIMS: It has been a challenge to confirm the association between laryngeal symptoms and physiological reflux disease. We examined the ability of oropharyngeal pH tests (with the Restech Dx-pH system) and salivary pepsin tests (with Peptest) to discriminate between asymptomatic volunteers (controls) and subjects with a combination of laryngeal and reflux symptoms (laryngeal ± reflux). METHODS: We performed a physician-blinded prospective cohort study of 59 subjects at a single academic institution...
April 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26487213/evaluation-of-the-need-for-routine-esophagram-after-peroral-endoscopic-myotomy-poem
#18
Rym El Khoury, Ezra N Teitelbaum, Joel M Sternbach, Nathaniel J Soper, Carla B Harmath, John E Pandolfino, Peter J Kahrilas, Eric S Hungness
BACKGROUND: Peroral endoscopic myotomy (POEM) is a novel surgical option for the treatment of achalasia. Most centers perform a routine esophagram on postoperative day (POD) #1 to rule esophageal perforation and leaks. In this study, we sought to determine the clinical utility of routine contrast studies post-POEM. METHODS: POEM was performed using an anterior submucosal tunnel and selective myotomy of the circular muscle layer. A routine contrast esophagram was obtained on POD #1...
July 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26404867/biomarkers-of-reflux-disease
#19
REVIEW
Leila Kia, John E Pandolfino, Peter J Kahrilas
Gastroesophageal reflux disease (GERD) encompasses an array of disorders unified by the reflux of gastric contents. Because there are many potential disease manifestations, esophageal and extraesophageal, there is no single biomarker of the entire disease spectrum; a set of GERD biomarkers that each quantifies specific aspects of GERD-related pathology might be needed. We review recent reports of biomarkers of GERD, specifically in relation to endoscopically negative esophageal disease and excluding conventional pH-impedance monitoring...
June 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26278501/the-functional-lumen-imaging-probe-detects-esophageal-contractility-not-observed-with-manometry-in-patients-with%C3%A2-achalasia
#20
COMPARATIVE STUDY
Dustin A Carlson, Zhiyue Lin, Peter J Kahrilas, Joel Sternbach, Erica N Donnan, Laurel Friesen, Zoe Listernick, Benjamin Mogni, John E Pandolfino
BACKGROUND & AIMS: The functional lumen imaging probe (FLIP) could improve the characterization of achalasia subtypes by detecting nonocclusive esophageal contractions not observed with standard manometry. We aimed to evaluate esophageal contractions during volumetric distention in patients with achalasia using FLIP topography. METHODS: Fifty-one treatment-naive patients with achalasia, defined and subclassified by high-resolution esophageal pressure topography, and 10 asymptomatic individuals (controls) were evaluated with the FLIP during endoscopy...
December 2015: Gastroenterology
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