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Candida tropicalis

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https://www.readbyqxmd.com/read/29782688/oral-yeast-colonization-in-patients-with-primary-and-secondary-sj%C3%A3-gren-s-syndrome
#1
Clarissa Castro Galvão Medeiros, Luiz Gustavo Dos Anjos Borges, Karen Cherubini, Fernanda Gonçalves Salum, Renata Medina da Silva, Maria Antonia Zancanaro de Figueiredo
OBJECTIVE: The study aimed to investigate the pattern of oral yeast colonization of Sjögren's syndrome patients and its correlation to salivary flow rates, age and time of the disease progression. MATERIALS AND METHODS: Saliva and swab specimens were obtained from 45 patients (primary Sjögren's syndrome= 15/ secondary Sjögren's syndrome= 15/ healthy controls= 15). Yeast species were identified using culture method through chromogenic medium followed by polymerase chain reaction and Sanger sequencing...
May 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29778633/comparative-analysis-of-proteinase-phospholipase-hydrophobicity-and-biofilm-forming-ability-in-candida-species-isolated-from-clinical-specimens
#2
S Dabiri, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
Candida species are the commensal organisms of human and animal mucosa that cause a wide range of debilitating diseases in immunocompromised patients and other susceptible individuals. The present study aimed to investigate the ability of clinical isolates of various Candida species to produce proteinase and phospholipase, hydrophobicity and biofilm forming ability that assumed to have a vital role in Candida pathogenicity. Eighty-four Candida strains belonged to Candida albicans (44.1%), C. glabrata (5.9%), C...
May 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29774204/non-canonical-activities-of-hog1-control-sensitivity-of-candida-albicans-to-killer-toxins-from-debaryomyces-hansenii
#3
Ana Morales-Menchén, Federico Navarro-García, José P Guirao-Abad, Elvira Román, Daniel Prieto, Ioana V Coman, Jesús Pla, Rebeca Alonso-Monge
Certain yeasts secrete peptides known as killer toxins or mycocins with a deleterious effect on sensitive yeasts or filamentous fungi, a common phenomenon in environmental species. In a recent work, different Debaryomyces hansenii ( Dh ) strains isolated from a wide variety of cheeses were identified as producing killer toxins active against Candida albicans and Candida tropicalis . We have analyzed the killer activity of these toxins in C. albicans mutants defective in MAPK signaling pathways and found that the lack of the MAPK Hog1 (but not Cek1 or Mkc1) renders cells hypersensitive to Dh mycocins while mutants lacking other upstream elements of the pathway behave as the wild type strain...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29767615/relevance-of-antifungal-penetration-in-biofilm-associated-resistance-of-candida-albicans-and-non-albicans-candida-species
#4
Rachna Singh, Anjna Kumari, Karminder Kaur, Parul Sethi, Arunaloke Chakrabarti
The role of penetration limitation in Candida biofilm-associated antifungal resistance remains unclear. Most of the previous work has been done on Candida albicans, although non-albicans (NAC) species are also implicated in invasive candidiasis and the biofilm matrix has been shown to vary amongst different species. Only a few studies have evaluated clinical isolates. This study aimed to determine the relevance of penetration limitation in the antifungal resistance of biofilms formed by C. albicans and NAC clinical isolates, using an agar disk diffusion assay...
May 16, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29762861/pharmacokinetic-pharmacodynamic-analysis-of-isavuconazole-against-aspergillus-spp-and-candida-spp-in-healthy-subjects-and-patients-with-hepatic-or-renal-impairment-by-monte-carlo-simulation
#5
Xiaowei Zheng, Gaoqi Xu, Liqin Zhu, Luo Fang, Yiwen Zhang, Haiying Ding, Yinghui Tong, Jiao Sun, Ping Huang
The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study is to evaluate the efficacy of various isavuconazole dosing regimens for healthy individuals and patients with hepatic or renal impairment against Aspergillus spp. and Candida spp. Monte Carlo simulations were conducted using pharmacokinetic (PK) parameters and pharmacodynamics (PD) data to determine the probabilities of target attainment and cumulative fractions of response in terms of area under the concentration curve/minimum inhibition concentration (AUC/MIC) targets of isavuconazole...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29753529/candidemia-in-the-intensive-care-unit-a-12-year-retrospective-cohort-study-in-reunion-island
#6
G Hoarau, S Picot, J Lemant, J Peytral, P Poubeau, P Zunic, C Mohr, X Coueffe, P Gerardin, E Antok
OBJECTIVES: We aimed to describe the epidemiology of Candida bloodstream infection in an intensive care unit (ICU) in Reunion Island. METHODS: We performed a retrospective cohort study and evaluated 63 candidemia episodes, which occurred between January 2004 and December 2015 in the ICU of a University Hospital in St-Pierre. RESULTS: The incidence rate of candidemia in the ICU was estimated at 7.6%. Candida albicans was the most common yeast pathogen species recovered (54%), followed by Candida glabrata (17%), Candida tropicalis (12%) and Candida parapsilosis (10%)...
May 9, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29751075/analysis-by-uplc-ms-qtof-and-antifungal-activity-of-guava-psidium-guajava-l
#7
Camila Fonseca Bezerra, Janaína Esmeraldo Rocha, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Amanda Karine de Sousa, Antônia Thassya Lucas Dos Santos, Rafael Pereira da Cruz, Maciel Horácio Ferreira, Josefa Carolaine Pereira da Silva, Antonio Judson Targino Machado, Joara Nályda Pereira Carneiro, Débora Lima Sales, Henrique Douglas Melo Coutinho, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Maria Flaviana Bezerra Morais-Braga
Psidium guajava L. is a plant widely used for food and in folk medicine all over the world. Studies have shown that guava leaves have antifungal properties. In this study, Flavonoid and Tannic fractions were tested to investigate their chemical composition and antifungal potential in vitro.21 compounds in the two fractions, presenting a higher content of phenolic compounds. The antifungal assays were performed against Candida albicans, Candida tropicalis and Candida krusei by microdilution to determine the IC50 and the cell viability curve...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29743305/five-year-national-surveillance-of-invasive-candidiasis-species-distribution-and-azole-susceptibility-from-the-china-hospital-invasive-fungal-surveillance-net-chif-net-study
#8
Meng Xiao, Zi-Yong Sun, Mei Kang, Da-Wen Guo, Kang Liao, Sharon C-A Chen, Fanrong Kong, Xin Fan, Jing-Wei Cheng, Xin Hou, Meng-Lan Zhou, Ying Li, Shu-Ying Yu, Jing-Jing Huang, He Wang, Ying-Chun Xu
Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility of Candida isolates in China are still limited. Here we report surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. Sixty-five tertiary hospitals collected 8,829 Candida isolates from August 1, 2009 to July 31, 2014. Matrix-assisted laser desorption/ionization -time of flight mass spectrometry supplemented by rDNA sequencing was used to define species, and fluconazole and voriconazole susceptibilities determined by the Clinical and Laboratory Standards Institute disk diffusion method...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29739588/chemical-composition-antifungal-activity-and-potential-anti-virulence-evaluation-of-the-eugenia-uniflora-essential-oil-against-candida-spp
#9
Joycy Francely Sampaio Dos Santos, Janaína Esmeraldo Rocha, Camila Fonseca Bezerra, Maria Karollyna do Nascimento Silva, Yedda Maria Lobo Soares de Matos, Thiago Sampaio de Freitas, Antonia Thassya Lucas Dos Santos, Rafael Pereira da Cruz, Antonio Júdson Targino Machado, Tigressa Helena Soares Rodrigues, Edy Sousa de Brito, Dédora Lima Sales, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga
The development of fungal resistance to antifungal drugs has been worsening over the years and as a result research on new antifungal agents derived from plants has intensified. Eugenia uniflora L. (pitanga) has been studied for its various biological actions. In this study the chemical composition and antifungal effects of the E. uniflora essential oil (EULEO) were investigated against Candida albicans (CA), Candida krusei (CK) and Candida tropicalis (CT) standard strains. The essential oil obtained through hydro-distillation was analyzed by gas chromatography coupled to mass spectrometry (GC-MS)...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29738604/five-year-profile-of-candidemia-at-an-indian-trauma-center-high-rates-of-candida-auris-blood-stream-infections
#10
Purva Mathur, Fahmi Hasan, Pradeep Kumar Singh, Rajesh Malhotra, Kamini Walia, Anuradha Chowdhary
BACKGROUND: Candidemia is a potentially fatal infection with varied distribution of Candida species and their antifungal susceptibility profiles. The recent emergence of Candida auris in invasive candidiasis is a cause for concern. This study describes the profile of candidemia at an Indian tertiary care hospital and reports the emergence of Candida auris. METHODS: All patients diagnosed as having candidemia between 2012 to 2017 were studied. The isolates were identified using conventional methods, VITEK 2 and by the MALDI-TOF MS...
May 8, 2018: Mycoses
https://www.readbyqxmd.com/read/29734333/a-coupled-process-of-same-and-opposite-sex-mating-generates-polyploidy-and-genetic-diversity-in-candida-tropicalis
#11
Han Du, Qiushi Zheng, Jian Bing, Richard J Bennett, Guanghua Huang
Sexual reproduction is a universal mechanism for generating genetic diversity in eukaryotes. Fungi exhibit diverse strategies for sexual reproduction both in nature and in the laboratory. In this study, we report the discovery of same-sex (homothallic) mating in the human fungal pathogen Candida tropicalis. We show that same-sex mating occurs between two cells carrying the same mating type (MTLa/a or α/α) and requires the presence of pheromone from the opposite mating type as well as the receptor for this pheromone...
May 7, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29734032/typing-and-virulence-factors-of-food-borne-candida-spp-isolates
#12
Katarzyna Rajkowska, Alina Kunicka-Styczyńska
Food-borne yeasts, excluding yeasts used as starter cultures, are commonly considered as food spoilage microorganisms. However, the incidence of non-C. albicans Candida (NCAC) infections has increased considerably over the past two decades. Although 15 Candida species are frequently identified as pathogens, a threat to human from food-borne Candida is poorly recognized. In the present study food-borne NCAC were characterized for the virulence factors, known to be associated with yeast pathogenicity. All food-borne strains in planktonic forms and 89% in biofilm structures represented biotypes established for C...
May 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29727512/comprehending-the-influence-of-critical-cultivation-parameters-on-the-oleaginous-behavior-of-potent-rotten-fruit-yeast-isolates
#13
Batul Diwan, Pratima Gupta
AIMS: Oleaginous yeasts were isolated from five different rotten fruits and their oleaginous behaviour was characterized with varying carbon source and concentration (C/N) to pave the path for their future applicabilities. METHODS & RESULTS: Sixteen yeasts were isolated, those accumulating around 20% of their cell dry weights as lipids were screened out and identified as Candida tropicalis and Pichia kudriavzevii. Amongst glucose, maltose, and sucrose, glucose was found favorable carbon source in terms of biomass yield and lipid content...
May 4, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29725781/application-of-a-low-cost-biosurfactant-in-heavy-metal-remediation-processes
#14
Rivaldo B da Rocha Junior, Hugo M Meira, Darne G Almeida, Raquel D Rufino, Juliana M Luna, Valdemir A Santos, Leonie A Sarubbo
The industrial interest in microbial surfactants has intensified in recent years due to the characteristics of these compounds, such as biodegradability, low toxicity, and effectiveness in removing heavy metals and hydrophobic organic compounds from soil and water. This paper describes the production of a biosurfactant by the yeast Candida tropicalis grown in distilled water with 2.5% molasses, 2.5% frying oil and 4% corn steep liquor. The production of the biosurfactant reached 27 g/l in a 50-l bioreactor with a surface tension of 30 mN/m...
May 4, 2018: Biodegradation
https://www.readbyqxmd.com/read/29718196/role-of-protein-phosphomannosylation-in-the-candida-tropicalis-macrophage-interaction
#15
Marco J Hernández-Chávez, Bernardo Franco, Diana M Clavijo-Giraldo, Nahúm V Hernández, Eine Estrada-Mata, Héctor Manuel Mora-Montes
Candida tropicalis is an opportunistic fungal pathogen responsible for mucosal and systemic infections. The cell wall is the initial contact point between a fungal cell and the host immune system, and mannoproteins are important components that play key roles when interacting with host cells. In C. albicans, mannans are modified by mannosyl-phosphate moieties, named phosphomannans, which can work as molecular scaffolds to synthesize β1,2-mannooligosaccharides, and MNN4 is a positive regulator of the phosphomannosylation pathway...
April 27, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29717970/role-of-biofilm-morphology-matrix-content-and-surface-hydrophobicity-in-the-biofilm-forming-capacity-of-various-candida-species
#16
Anjna Kumari, Sakshi Mankotia, Bhawna Chaubey, Monika Luthra, Rachna Singh
The present study aimed to evaluate the role of biofilm morphology, matrix content and surface hydrophobicity in the biofilm-forming capacity of Candida albicans and non-albicans Candida (NAC) spp. Biofilm formation was determined by microtitre plate assay and bright-field and scanning electron microscopy. The matrix carbohydrates, proteins and e-DNA were quantified by phenol-sulfuric acid, bicinchoninic acid and UV spectroscopy, respectively. Specific glycosyl residues were detected by dot blot. The cell-surface hydrophobicity was determined by hydrocarbon adhesion assay...
May 2, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29707676/mycological-aspects-of-onychomycosis-in-khuzestan-province-iran-a-shift-from-dermatophytes-towards-yeasts
#17
Mahnaz Fatahinia, Sima Jafarpour, Abdollah Rafiei, Simin Taghipour, Koichi Makimura, Ali Rezaei-Matehkolaei
Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran, have not been established. In this study, we aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran. Materials and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples underwent primary direct microscopy and culture...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29707675/identification-of-candida-species-isolated-from-vulvovaginitis-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#18
Majid Alizadeh, Anna Kolecka, Teun Boekhout, Hossein Zarrinfar, Mohamad A Ghanbari Nahzag, Parisa Badiee, Ali Rezaei-Matehkolaei, Abdolmajid Fata, Somayeh Dolatabadi, Mohammad J Najafzadeh
Background and Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify Candida isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran. Materials and Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. All specimens were identified using phenotyping techniques, such as microscopy and culture on Sabouraud dextrose agar and corn meal agar...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29707672/evaluation-of-esterase-and-hemolysin-activities-of-different-candida-species-isolated-from-vulvovaginitis-cases-in-lorestan-province-iran
#19
Maryam Noori, Mohammad Dakhili, Asghar Sepahvand, Nader Davari
Background and Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of  Candida  species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency. Herein, we aimed to evaluate the esterase and hemolysin activities of the vaginal isolates of Candida and their relationship with the presence of VVC...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29696003/multilocus-sequence-typing-reveals-a-new-cluster-of-closely-related-candida-tropicalis-genotypes-in-italian-patients-with-neurological-disorders
#20
Fabio Scordino, Letterio Giuffrè, Giuseppina Barberi, Francesca Marino Merlo, Maria Grazia Orlando, Domenico Giosa, Orazio Romeo
Candida tropicalis is a pathogenic yeast that has emerged as an important cause of candidemia especially in elderly patients with hematological malignancies. Infections caused by this species are mainly reported from Latin America and Asian-Pacific countries although recent epidemiological data revealed that C. tropicalis accounts for 6-16.4% of the Candida bloodstream infections (BSIs) in Italy by representing a relevant issue especially for patients receiving long-term hospital care. The aim of this study was to describe the genetic diversity of C...
2018: Frontiers in Microbiology
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