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Candida tropicalis

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https://www.readbyqxmd.com/read/28527284/-new-multiplex-pcr-for-species-specific-diagnosis-of-human-candidiasis
#1
Liliana Torcoroma García, Liany Johanna Luna, Tania Katherine Velasco, Beatriz Elena Guerra
INTRODUCTION: Candidiases is a group of opportunistic infections caused by yeasts belonging to the genus Candida. Candida albicans is the most prevalent species in both superficial and deep infections, however, the clinical importance of non-albicans Candida has increased during the last decade, driving an urgent need for diagnostic tests that allow for species-level resolution and selection of the optimum therapeutic approach. OBJECTIVE: To design and to optimize a new multiplex PCR assay for the simultaneous identification of the five most relevant species of Candida involved in human candidiasis etiology...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527136/factors-influencing-non-albicans-candidemia-a-case-case-control-study
#2
Diamantis P Kofteridis, Antonis Valachis, Dimitra Dimopoulou, Angeliki M Andrianaki, Athanasia Christidou, Sofia Maraki, Nikolaos A Spernovasilis, George Samonis
The study identified factors predisposing to non-albicans candidemia with special interest to prior antimicrobial treatment. A retrospective, case-case-control study was performed at the University Hospital of Heraklion, Greece, from November 2007 through September 2011 including adult patients. The study had three groups. The first included 58 patients with non-albicans candidemia, the second 48 with C. albicans candidemia, while the third (control) 104 without candidemia. Each of the two candidemia groups was compared with the control using multivariate logistic regression model...
May 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28525644/risk-factors-and-clinical-outcomes-of-breakthrough-yeast-bloodstream-infections-in-patients-with-hematological-malignancies-in-the-era-of-newer-antifungal-agents
#3
Si-Hyun Kim, Jae-Ki Choi, Sung-Yeon Cho, Hyo-Jin Lee, Sun Hee Park, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo, Jong-Wook Lee
Although yeast bloodstream infections (BSIs) are increasingly being reported in patients with hematological malignancies undergoing antifungal therapy, clinical information regarding breakthrough infections is scarce. The aim of this study was to determine the risk factors for and clinical outcomes of breakthrough yeast BSIs in patients with hematological malignancies in the era of newer antifungal agents. Between 2011 and 2014, all consecutive patients with hematological malignancies who developed yeast BSIs were included in a case-control study wherein breakthrough infections (cases) and de novo infections (controls) were compared...
May 19, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28507109/erg11-gene-mutations-and-mdr1-up-regulation-confer-pan-azole-resistance-in-candida-tropicalis-causing-disseminated-candidiasis-while-on-posaconazole-prophylaxis-in-an-acute-lymphoblastic-leukemia-patient
#4
Liangshun You, Wenbin Qian, Qing Yang, Liping Mao, Li Zhu, Xianbo Huang, Jie Jin, Haitao Meng
In this study, we presented a rare case of fatal breakthrough Candida tropicalis in a patient with acute lymphoblastic leukemia (ALL) while on posaconazole prophylaxis. And then we explored the mechanisms underlying azole resistance by focusing on enhanced efflux pumps and changes in the azole target enzyme Erg11p, which was encoded by the ERG11 gene. Our study demonstrates that Y132C substitution of Erg11p combined with MDR1 overexpression may be the pan-azole-resistance mechanisms in Candida tropicalis.
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28506251/diversity-in-vitro-virulence-traits-and-antifungal-susceptibility-pattern-of-gastrointestinal-yeast-flora-of-healthy-poultry-gallus-gallus-domesticus
#5
Supram Hosuru Subramanya, Nawal Kishor Sharan, Bharat Prasad Baral, Deependra Hamal, Niranjan Nayak, Peralam Yegneswaran Prakash, Brijesh Sathian, Indira Bairy, Shishir Gokhale
BACKGROUND: Poultry farming and consumption of poultry (Gallus gallus domesticus) meat and eggs are common gastronomical practices worldwide. Till now, a detailed understanding about the gut colonisation of Gallus gallus domesticus by yeasts and their virulence properties and drug resistance patterns in available literature remain sparse. This study was undertaken to explore this prevalent issue. RESULTS: A total of 103 specimens of fresh droppings of broiler chickens (commercial G domesticus) and domesticated chickens (domesticated G domesticus) were collected from the breeding sites...
May 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28486529/ag-i-camphorimine-complexes-with-antimicrobial-activity-towards-clinically-important-bacteria-and-species-of-the-candida-genus
#6
João M S Cardoso, Soraia I Guerreiro, Andreia Lourenço, Marta M Alves, M Fátima Montemor, Nuno P Mira, Jorge H Leitão, M Fernanda N N Carvalho
The present work follows a previous report describing the antibacterial activity of silver camphorimine complexes of general formula [Ag(NO3)L]. The synthesis and demonstration of the antifungal and antibacterial activity of three novel [Ag(NO3)L] complexes (named 1, 2 and 3) is herein demonstrated. This work also shows for the first time that the previously studied complexes (named 4 to 8) also exert antifungal activity. The antibacterial activity of complexes was evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia contaminans and Escherichia coli strains, while antifungal activity was tested against the Candida species C...
2017: PloS One
https://www.readbyqxmd.com/read/28479680/an-in-vitro-study-of-isolation-of-candidal-strains-in-oral-squamous-cell-carcinoma-patients-undergoing-radiation-therapy-and-quantitative-analysis-of-the-various-strains-using-chromagar
#7
Mohammad Mohsin Abdul Razak Ainapur, Pushpalatha Mahesh, K Vinod Kumar, A Deepak, Ujjwal Mrinal, P Sharada
BACKGROUND: Patients undergoing radiation therapy for oral squamous cell carcinoma (OSCC) have an increased risk of developing oral candidiasis. Radiation-induced hyposalivation is thought to be a major predisposing factor for it. Radiation therapy for 2-3 weeks leads to increase in the number of candidal species in the oral cavity, eventually leading to oral candidiasis. OBJECTIVE: To evaluate and correlate the prevalence of candidal species in the oral cavity of OSCC patients and to compare with radiation dosage at 3(rd) and 6(th) week following radiotherapy...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479098/synthesis-cytotoxicity-and-antifungal-activity-of-5-nitro-thiophene-thiosemicarbazones-derivatives
#8
Luiz Nascimento de Araújo Neto, Maria do Carmo Alves de Lima, Jamerson Ferreira de Oliveira, Edson Rubhens de Souza, Maria Daniela Silva Buonafina, Mayara Nunes Vitor Anjos, Fábio André Brayner, Luiz Carlos Alves, Rejane Pereira Neves, Francisco Jaime Bezerra Mendonça-Junior
In the present work, twelve N-substituted 2-(5-nitro-thiophene)-thiosemicarbazones derivatives (L1-12) were synthesized, characterized and their cytotoxic and antifungal activity in vitro were evaluated against Candida sp., and Cryptococcus neoformans. The probable mechanisms of action have been investigated in cell walls (Sorbitol 0.8 M) and in the binding to ergosterol in the fungal membrane. Additionally, ultrastructural study by Scanning Electron Microscopy was performed. All compounds were obtained in good yield and their chemical structures were characterized on basis of their physico-chemical and Nuclear Magnetic Resonance - NMR, Spectrophotometric Absorption in the Infrared - IR and High-resolution Mass Spectrometry - HRMS data...
May 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28460978/pichia-kudrazevii-and-candida-nitrativorans-are-the-most-well-adapted-and-relevant-yeast-species-fermenting-cocoa-in-agneby-tiassa-a-local-ivorian-cocoa-producing-region
#9
Lamine Samagaci, Honoré Ouattara, Sébastien Niamké, Marc Lemaire
Cocoa bean fermentation is a spontaneous and still poorly controlled process that very often leads to end-products of heterogeneous quality. This fermentation is driven by a succession of complex microbial communities where yeasts play key roles during the first stages of the process. In this study, we identified and analyzed the growth dynamics of yeasts involved in cocoa bean fermentation from the Ivorian region called Agneby-Tiassa. The results showed that Pichia kudriazevii and Candida nitrativorans were the dominant yeasts in fermented cocoa from Agneby-Tiassa...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28460934/bioactive-properties-and-functional-constituents-of-hypericum-androsaemum-l-a-focus-on-the-phenolic-profile
#10
Inés Jabeur, Flávia Tobaldini, Natália Martins, Lillian Barros, Ivone Martins, Ricardo C Calhelha, Mariana Henriques, Sónia Silva, Lotfi Achour, Celestino Santos-Buelga, Isabel C F R Ferreira
Hypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. A marked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lines was also observed, whereas no toxicity was shown against non-tumor porcine liver cells (>400μg/mL). The extract was also effective in inhibiting nitric oxide production, as an indicator of the anti-inflammatory potential. The anti-Candida effects varied among different strains of the same species, C...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28459966/efficacy-of-anidulafungin-in-539-patients-with-invasive-candidiasis-a-patient-level-pooled-analysis-of-six-clinical-trials
#11
Bart Jan Kullberg, José Vasquez, Piroon Mootsikapun, Marcio Nucci, José-Artur Paiva, Jorge Garbino, Jean Li Yan, Jalal Aram, Maria Rita Capparella, Umberto Conte, Haran Schlamm, Robert Swanson, Raoul Herbrecht
Objectives: To evaluate the efficacy of anidulafungin for the treatment of candidaemia and invasive candidiasis in a large dataset, including patients with deep-seated tissue candidiasis, neutropenia and infection due to non- albicans Candida species. Methods: Data were pooled from six prospective, multicentre, multinational studies: four open-label, non-comparative studies of anidulafungin and two double-blind, double-dummy, randomized studies of anidulafungin versus caspofungin (clinical trial registrations: NCT00496197, NCT00548262, NCT00537329, NCT00689338, NCT00806351 and NCT00805740; ClinicalTrials...
April 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28454680/healing-potential-of-zerumbone-ointment-on-experimental-full-thickness-excision-cutaneous-wounds-in-rat
#12
Wayne Young Liu, Thing-Fong Tzeng, I-Min Liu
Zerumbone is a monocyclic sesquiterpene compound. Based on report, it is the predominant bioactive compound from the rhizomes of Zingiber zerumbet. The study was undertaken to evaluate the therapeutic effects of topical zerumbone on excision wounds in rats. A 1% (w/w) simple ointment containing zerumbone was applied topically (100 mg ointment per rat) once a day on full-thickness excision wounds created on rats. The wound tissue was removed and used for estimation of antioxidant activity and to observe histopathological changes...
April 15, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28452022/xylitol-production-from-non-detoxified-and-non-sterile-lignocellulosic-hydrolysate-using-low-cost-industrial-media-components
#13
Tatyaso Yewale, Shruti Panchwagh, Shaileshkumar Sawale, Rishi Jain, Pradip B Dhamole
Immobilized Candida tropicalis cells in freeze dried calcium alginate beads were used for production of xylitol from lignocellulosic waste like corn cob hydrolysate without any detoxification and sterilization of media. Media components for xylitol fermentation were screened by statistical methods. Urea, KH2PO4 and initial pH were identified as significant variables by Plackett-Burman (PB) design. Significant medium components were optimized by response surface methodology (RSM). Predicted xylitol yield by RSM model and experimental yield was 0...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28427664/ultrasonic-irradiation-of-low-intensity-with-a-mode-of-sweeping-frequency-enhances-the-membrane-permeability-and-cell-growth-rate-of-candida-tropicalis
#14
Guoping Huang, Yingxiu Tang, Ling Sun, Huan Xing, Haile Ma, Ronghai He
Here we report the enhancement of both cellular permeability and cell growth rate of Candida tropicalis after treatment with the ultrasonic irradiation of low intensity using a mode of sweeping frequency (UILS) generated by a self-developed ultrasonic device in our lab. After the ultrasonic treatment, remarkable biomass enhancement of the yeast was observed; the hyphae became significantly longer; the seeped cellular protein and nucleic acid from the yeast increased and the cellular Ca(2+) content became lower...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28419092/a-multi-centric-study-of-candida-bloodstream-infection-in-lima-callao-peru-species-distribution-antifungal-resistance-and-clinical-outcomes
#15
MULTICENTER STUDY
Lourdes Rodriguez, Beatriz Bustamante, Luz Huaroto, Cecilia Agurto, Ricardo Illescas, Rafael Ramirez, Alberto Diaz, Jose Hidalgo
BACKGROUND: The incidence of candidemia is increasing in developing countries. Very little is known about the epidemiology of candidemia in Peru. The aim of this study is to describe the incidence, microbiology, clinical presentation and outcomes of Candida bloodstream infections in three Lima-Callao hospitals. METHODS: Candida spp. isolates were identified prospectively at participant hospitals between November 2013 and January 2015. Susceptibility testing for amphotericin B, fluconazole, posaconazole, voriconazole and anidulafungin was performed using broth microdilution method...
2017: PloS One
https://www.readbyqxmd.com/read/28417524/biofilms-of-candida-spp-from-the-ocular-conjunctiva-of-horses-with-reduced-azole-susceptibility-a-complicating-factor-for-the-treatment-of-keratomycosis
#16
Raimunda Sâmia Nogueira Brilhante, Paula Vago Bittencourt, Débora de Souza Collares Castelo-Branco, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Lucas Pereira Alencar, Rossana de Aguiar Cordeiro, Mariana Pinheiro, Evilázio Fernandes Nogueira-Filho, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
OBJECTIVES: This study aimed to assess the biofilm-forming ability of Candida spp. from the ocular conjunctiva of horses and to investigate the antifungal susceptibility of these biofilms. PROCEDURES: Initially, the biofilm-forming ability of 15 strains was assessed by crystal violet staining, which reveals the fungal biomass adhered to the polystyrene plates, and scanning electron microscopy. Then, the minimum inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole, and caspofungin were initially determined against strains in planktonic form...
April 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28402525/antifungal-mechanism-of-ruiii-nh3-4catechol-complex-on-fluconazole-resistant-candida-tropicalis
#17
Rafael Araújo Gomes-Junior, Roberto Santana da Silva, Renata Galvão de Lima, Marcos A Vannier-Santos
Candidiasis, a major opportunistic mycosis caused by Candida sp., may comprise life-threatening systemic infections. The incidence of non-albicans species is rising, particularly in South America and they are frequently drug resistant, causing unresponsive cases. Thus, novel antimycotic agents are required. Here we tested the antifungal activity of [RuIII(NH3)4catechol]+ complex (RuCat), approaching possible action mechanisms on fluconazole-resistant Candida tropicalis. RuCat significantly (P < 0.05) inhibited the growth and viability of C...
May 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28394977/-clinical-and-epidemiological-changes-of-candidemia-among-adult-patients-from-2000-to-2013
#18
Leonardo Siri, Paulette Legarraga, Patricia García, Tamara González, Ricardo Rabagliati
BACKGROUND: Invasive Candida spp. infections have been described more frequently. AIM: To characterize the epidemiological data of candidemia in recent years. METHODS: A retrospective study of adult patients in a University Hospital in Santiago, Chile, with 1 or more documented episodes of candidemia, from January 2000 to December 2013. RESULTS: One hundred and twenty episodes of candidemia were identified in 120 patients, annual incidence of 0...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28384860/fungal-opportunistic-pneumonias-in-hiv-aids-patients-an-indian-tertiary-care-experience
#19
Ravinder Kaur, Bhanu Mehra, Megh Singh Dhakad, Ritu Goyal, Preena Bhalla, Richa Dewan
INTRODUCTION: Opportunistic pneumonias are a major cause of mortality and morbidity in Human Immunodeficiency Virus (HIV) reactive patients. Despite the significant role that fungi play in causation of this opportunistic mycoses, very few Indian studies have attempted to investigate the burden and aetiological spectrum of HIV/AIDS-associated fungal pneumonias. AIM: To document the prevalence of fungal aetiology in HIV/AIDS-related opportunistic pneumonias in an Indian setting; and to elucidate the various fungal opportunists responsible for the same...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382028/notable-increasing-trend-in-azole-non-susceptible-candida-tropicalis-causing-invasive-candidiasis-in-china-august-2009-to-july-2014-molecular-epidemiology-and-clinical-azole-consumption
#20
Xin Fan, Meng Xiao, Kang Liao, Timothy Kudinha, He Wang, Li Zhang, Xin Hou, Fanrong Kong, Ying-Chun Xu
Objectives: To report the notable increasing trends of C. tropicalis antifungal resistance in the past 5 years, and explore molecular epidemiology, and the relationship between clinical azoles consumption and increased resistance rate. Methods: Between August 2009 and July 2014, 507 non-duplicated C. tropicalis isolates causing invasive candidiasis were collected from 10 hospitals in China. The in vitro antifungal susceptibility of nine common agents was determined by Sensititre YeastOne™ using current available species-specific clinical breakpoint (CBPs) or epidemiological cut-off values (ECVs)...
2017: Frontiers in Microbiology
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