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Penicillium marneffei

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https://www.readbyqxmd.com/read/28182077/penicillium-marneffei-infection-in-a-hiv-positive-patient-a-comparison-of-bronchial-washing-cytology-and-biopsy
#1
Chu Hyun Hee, Chong Young Pil, Kyung Ja Cho
Penicilliosis is a disseminated and progressive infection that is mainly found in immunocompromised individuals, especially those with human immunodeficiency virus (HIV) infection. Because of the high mortality of patients with disseminated Penicillium marneffei infection, rapid diagnosis and early treatment are required. Diagnosis is traditionally made by biopsy and/or culture of blood or any involved organ. Cytology offers several advantages over biopsy, including more rapid diagnosis and greater resolution of cytomorphologic details of organisms, allowing rapid initiation of treatment...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28130931/a-retrospective-analysis-of-seven-patients-with-acquired-immunodeficiency-syndrome-and-pharyngeal-and-or-laryngeal-talaromyces-marneffei-infection
#2
Ye Qiu, Yanping Tang, Jianquan Zhang, Xiang Yi, Xiaoning Zhong, Guangnan Liu, Haiguang Xu, Yan Lei
1.Talaromyces marneffei, formerly known as Penicillium marneffei, usually affects the monocyte-macrophage system and can cause fatal systemic mycosis in immunocompromised individuals. This retrospective study is the first to describe the clinical and endoscopic (nasal endoscopy, flexible endoscopy) features of penicilliosis with pharynx and/or larynx infection in patients with acquired immunodeficiency syndrome (AIDS). 2.During the study period, 126 patients were diagnosed with penicilliosis. Among them, only seven who presented with culture and/or histopathological evidence of pharyngeal and/or laryngeal T...
January 28, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28111099/talaromyces-marneffei-mp1p-is-a-virulence-factor-that-binds-and-sequesters-a-key-proinflammatory-lipid-to-dampen-host-innate-immune-response
#3
Kong-Hung Sze, Wai-Hei Lam, Hongmin Zhang, Yi-Hong Ke, Man-Kit Tse, Patrick C Y Woo, Susanna K P Lau, Candy C Y Lau, Jian-Piao Cai, Edward T K Tung, Raymond K C Lo, Simin Xu, Richard Y T Kao, Quan Hao, Kwok-Yung Yuen
Talaromyces (Penicillium) marneffei is one of the leading causes of systemic mycosis in immunosuppressed or AIDS patients in Southeast Asia. How this intracellular pathogen evades the host immune defense remains unclear. We provide evidence that T. marneffei depletes levels of a key proinflammatory lipid mediator arachidonic acid (AA) to evade the host innate immune defense. Mechanistically, an abundant secretory mannoprotein Mp1p, shown previously to be a virulence factor, does so by binding AA with high affinity via a long hydrophobic central cavity found in the LBD2 domain...
January 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28108867/administration-of-voriconazole-in-disseminated-talaromyces-penicillium-marneffei-infection-a-retrospective-study
#4
Yanyin Ouyang, Shuangqi Cai, Hao Liang, Cunwei Cao
Talaromyces (Penicillium) marneffei infection is a fatal disseminated mycosis caused by the dimorphic fungus Talaromyces marneffei; the therapeutic strategies for this infectious disease are limited. The aim of this retrospective study was to evaluate the efficacy and safety of voriconazole for treating patients with disseminated T. marneffei infection with or without HIV infection in a clinical setting. Patients who intravenously received voriconazole (6 mg/kg q12 h for the first 24 h followed by 4 mg/kg q12 h) as the initial antifungal treatment were enrolled...
January 20, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28105364/disseminated-penicillium-marneffei-infection-recurrence-in-a-non-acquired-immune-deficiency-syndrome-patient-a-case-report
#5
Zhixue Zhang, Fangxu Tao, Yining Li, Yudong Xiao, Zhishu Zhang, Jun Liu
Penicillium marneffei is a rare deep tissue fungal infection causing an endemic in Southeast Asia. This infection causes penicilliosis disease and is more common in patients who are immunocompromised. To date, no cases of P. marneffei infection relapse following treatment have been reported. A 36-year-old patient attended our hospital as a result of intermittent fever, cough, shortness of breath and multiple soft lesions located on the face, arms, neck and trunk. The medical radiological examination of the lung revealed multiple patchy exudative shadows, thick-walled hollow inner part of the visible lesions, bilateral pleural and pericardial effusion...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28104384/retrospective-analysis-of-15-cases-of-penicillium-marneffei-infection-in-hiv-positive-and-hiv-negative-patients
#6
REVIEW
Yinyin Li, Zhongyuan Lin, Xiang Shi, Lijun Mo, Wenchao Li, Wuning Mo, Zheng Yang
Penicillium marneffei (P. marneffei) causes systemic opportunistic infections in immunocompromised individuals, particularly in those infected with human immunodeficiency virus (HIV), and more rarely in HIV-negative patients. We retrospectively analyzed the cases of 15 patients infected with P. marneffei. The patients were divided into two groups: HIV-negative (n = 4) and HIV-positive (n = 11). Of the cases studied, three (75%) of the HIV-negative and six (55%) of the HIV-positive group had an accompanying lung infection...
January 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28011700/role-of-the-talaromyces-marneffei-penicillium-marneffei-saka-gene-in-nitrosative-stress-response-conidiation-and-red-pigment-production
#7
Panjaphorn Nimmanee, Emily W T Tam, Patrick C Y Woo, Pramote Vanittanakom, Nongnuch Vanittanakom
Stress-activated MAPK (SAPK) pathways are systems used to regulate the stress adaptation of most fungi. It has been shown that in Talaromyces marneffei (Penicillium marneffei), a pathogenic dimorphic fungus, the sakA gene is involved, not only in tolerance against oxidative and heat stresses, but also in playing a role in asexual development, yeast cell generation in vitro and survival inside macrophage cell lines. In this study, the role of the T. marneffei sakA gene on the nitrosative stress response, and the regulation of gene expression were investigated...
December 22, 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27984058/enhancing-melting-curve-analysis-for-the-discrimination-of-loop-mediated-isothermal-amplification-products-from-four-pathogenic-molds-use-of-inorganic-pyrophosphatase-and-its-effect-in-reducing-the-variance-in-melting-temperature-values
#8
Kazuya Tone, Ryuichi Fujisaki, Takashi Yamazaki, Koichi Makimura
Loop-mediated isothermal amplification (LAMP) is widely used for differentiating causative agents in infectious diseases. Melting curve analysis (MCA) in conjunction with the LAMP method reduces both the labor required to conduct an assay and contamination of the products. However, two factors influence the melting temperature (Tm) of LAMP products: an inconsistent concentration of Mg(2+) ion due to the precipitation of Mg2P2O7, and the guanine-cytosine (GC) content of the starting dumbbell-like structure. In this study, we investigated the influence of inorganic pyrophosphatase (PPase), an enzyme that inhibits the production of Mg2P2O7, on the Tm of LAMP products, and examined the correlation between the above factors and the Tm value using MCA...
January 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27817782/-recurrent-fever-hepatosplenomegaly-and-eosinophilia-in-a-boy
#9
Dan Liu, Li-Li Zhong, Yun Li, Min Chen
A 2-year-old boy was admitted into the hospital because of cough and fever. Lymph node tuberculosis was noted when he was 2 months old and he was subsequently hospitalized several times because of cough and fever. After hospitalization the laboratory examination showed an increased eosinophia level in blood. The immune function tests shows decreased levels of IgG, IgA, and IgM. The patient had no response to anti-tuberculosis, anti-bacterial, and anti-fungal treatment, resulting in recurrent fever and progressive enlargement of the liver and spleen...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27787346/association-of-hiv-and-opportunistic-infections-with-incident-stroke-a-nationwide-population-based-cohort-study-in-taiwan
#10
Yung-Feng Yen, Marcelo Chen, Ian Jen, Yu-Ching Lan, Pei-Hung Chuang, Yen-Ling Liu, Yun Lee, Yi-Ming Arthur Chen
BACKGROUND: HIV-associated vasculopathy and opportunistic infections (OIs) might cause vascular atherosclerosis and aneurysmal arteriopathy, which could increase the risk of incident stroke. However, few longitudinal studies have investigated the link between HIV and incident stroke. This cohort study evaluated the association of HIV and OIs with incident stroke. METHODS: We identified adults with HIV infection in 2000-2012, using the Taiwan National Health Insurance Research Database...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27706212/the-yapa-encodes-bzip-transcription-factor-involved-in-stress-tolerance-in-pathogenic-fungus-talaromyces-marneffei
#11
Wiyada Dankai, Monsicha Pongpom, Sirida Youngchim, Chester R Cooper, Nongnuch Vanittanakom
Talaromyces marneffei, formerly Penicillium marneffei, is a thermally dimorphic fungus. It causes a fatal disseminated disease in patients infected with the human immunodeficiency virus (HIV). Studies on the stress defense mechanism of T. marneffei can lead to a better understanding of the pathogenicity and the progression of the disease due to this fungus. The basic leucine-zipper (bZip) transcription factor gene in Saccharomyces cerevisiae, named yap1 (yeast activating protein-1), is known as a crucial central regulator of stress responses including those caused by oxidative agents, cadmium, and drugs...
2016: PloS One
https://www.readbyqxmd.com/read/27580558/penicillium-marneffei-infection-with-%C3%AE-d-glucan-elevation-a-case-report-and-literature-review
#12
Yukihiro Yoshimura, Yohei Sakamoto, Kwangyeol Lee, Yuichiro Amano, Natsuo Tachikawa
We herein report a case of Penicillium marneffei infection (PMI) in a Japanese man who was infected with human immunodeficiency virus-1 (HIV-1), who was diagnosed on the basis of a bone marrow culture and who was effectively treated with itraconazole. Our review of the PMI cases reported in Japan suggests that increased serum (1→3)-β-D-glucan levels are a useful diagnostic tool in cases of suspected PMI.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27560160/mp1p-is-a-virulence-factor-in-talaromyces-penicillium-marneffei
#13
Patrick C Y Woo, Susanna K P Lau, Candy C Y Lau, Edward T K Tung, Ken T K Chong, Fengjuan Yang, Hongmin Zhang, Raymond K C Lo, Jian-Pao Cai, Rex K H Au-Yeung, Wing-Fung Ng, Herman Tse, Samson S Y Wong, Simin Xu, Wai Hei Lam, Man-Kit Tse, Kong Hung Sze, Richard Y Kao, Neil E Reiner, Quan Hao, Kwok-Yung Yuen
BACKGROUND: Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homologs are virulence factors. METHODOLOGY/PRINCIPAL FINDINGS: We examined the pathogenic roles of Mp1p and its homologs in a mouse model. All mice died 21 and 30 days after challenge with wild-type T...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27535731/penicillium-keratitis-in-a-hiv-infected-patient
#14
REVIEW
Orapin Anutarapongpan, Onsiri Thanathanee, Olan Suwan-Apichon
A 36-year-old HIV-positive man presented with symptoms of redness, blurred vision and foreign body sensation in his right eye for 3 months. The slit lamp examination revealed deep stromal infiltration with a feathery margin in an otherwise minimal anterior chamber reaction. A corneal scraping was negative. Confocal microscopy demonstrated an abnormal large hyper-reflective oval shape in the corneal stroma. Corneal infiltration did not show improvement after topical, intrastromal and intracameral antifungal treatment...
August 17, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27502930/etiology-and-clinical-features-of-229-cases-of-bloodstream-infection-among-chinese-hiv-aids-patients-a-retrospective-cross-sectional-study
#15
T Qi, R Zhang, Y Shen, L Liu, D Lowrie, W Song, J Chen, Z Wang, J Shen, R Cai, L Guan, B Luo, Y Tang, H Lu
Bloodstream infections (BSIs) are prevalent among people living with HIV/AIDS. The etiology varies in different regions and different periods. We aimed to survey the etiological and clinical features of BSIs in HIV patients in mainland China. We assessed all HIV patients with a positive blood culture in a Chinese teaching hospital from September 2009 through December 2014. We excluded those with specimens likely to have been contaminated. We used Pearson's chi-squared test to measure the differences in characteristics among subgroups of different pathogens...
November 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27453379/development-and-evaluation-of-a-real-time-polymerase-chain-reaction-assay-for-the-rapid-detection-of-talaromyces-marneffei-mp1-gene-in-human-plasma
#16
Ha Thuc Ai Hien, Tran Tan Thanh, Nguyen Thi Mai Thu, Ashley Nguyen, Nguyen Tat Thanh, Nguyen Phu Huong Lan, Cameron Simmons, Cecilia Shikuma, Nguyen Van Vinh Chau, Guy Thwaites, Thuy Le
Penicilliosis caused by Talaromyces marneffei is a common AIDS-defining illness in South and Southeast Asia. Diagnosis is based on culture which can take up to 14 days for identification, leading to treatment delay and increased mortality. We developed a TaqMan real-time PCR assay targeting the MP1 gene encoding an abundant cell wall protein specific to T. marneffei. The assay's performance was evaluated in MP1-containing plasmids, clinical isolates, and plasma from HIV-infected patients with and without penicilliosis...
July 25, 2016: Mycoses
https://www.readbyqxmd.com/read/27419165/disseminated-talaromyces-marneffei-and-mycobacterium-abscessus-in-a-patient-with-anti-interferon-%C3%AE-autoantibodies
#17
Nattapol Pruetpongpun, Thana Khawcharoenporn, Pansachee Damronglerd, Worapop Suthiwartnarueput, Anucha Apisarnthanarak, Sasinuch Rujanavej, Nuntra Suwantarat
Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successfully treated with antimicrobial therapy and rituximab to control B cell-derived autoantibodies.
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27367328/pulmonary-infection-caused-by-talaromyces-purpurogenus-in-a-patient-with-multiple-myeloma
#18
Altay Atalay, Ayse Nedret Koc, Gulsah Akyol, Nuri Cakir, Leylagul Kaynar, Aysegul Ulu-Kilic
A 66-year-old female patient with multiple myeloma (MM) was admitted to the emergency service on 29.09.2014 with an inability to walk, and urinary and faecal incontinence. She had previously undergone autologous bone marrow transplantation (ABMT) twice. The patient was hospitalized at the Department of Haematology. Further investigations showed findings suggestive of a spinal mass at the T5-T6-T7 level, and a mass lesion in the iliac fossa. The mass lesion was resected and needle biopsy was performed during a colonoscopy...
June 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27273648/two-unusual-cases-of-human-immunodeficiency-virus-negative-patients-with-talaromyces-marneffei-infection
#19
Ye Qiu, Mingqi Pan, Jianquan Zhang, Xiaoning Zhong, Yu Li, Hui Zhang, Bixun Li
Talaromyces marneffei (formerly known as Penicillium marneffei) is a dimorphic fungus endemic in south and southeast Asia. It is not only commonly found in human immunodeficiency virus (HIV)-infected patients, but also among HIV-negative immunocompromised patients. The infection caused by this pathogen can disseminate hematogenously to other locations. Herein, we report for the first time two cases complicated with a rare disease or involving a rare site: in the first case, T. marneffei infection was complicated by Langerhans cell histiocytosis, whereas the second case showed clear etiological evidence of pleural nodules and pleural effusion caused by T...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27224737/talaromyces-marneffei-laccase-modifies-thp-1-macrophage-responses
#20
Ariya Sapmak, Jutikul Kaewmalakul, Joshua D Nosanchuk, Nongnuch Vanittanakom, Alex Andrianopoulos, Kritsada Pruksaphon, Sirida Youngchim
Talaromyces (Penicillium) marneffei is an emerging opportunistic pathogen associated with HIV infection, particularly in Southeast Asia and southern China. The rapid uptake and killing of T. marneffei conidia by phagocytic cells along with the effective induction of an inflammatory response by the host is essential for disease control. T. marneffei produces a number of different laccases linked to fungal virulence. To understand the role of the various laccases in T. marneffei, laccase-encoding genes were investigated...
August 17, 2016: Virulence
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