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https://www.readbyqxmd.com/read/29679899/postpartum-posttraumatic-and-acute-stress-in-mothers-and-fathers-of-infants-with-very-low-birth-weight-cross-sectional-results-from-a-controlled-multicenter-cohort-study
#1
Nadine Helle, Claus Barkmann, Stephan Ehrhardt, Carola Bindt
BACKGROUND: The birth of a preterm infant can be stressful and traumatic for parents and may cause posttraumatic stress symptoms and disorders. There is a dearth of data from controlled studies regarding level, prevalence, risk, and predictors of these symptoms in parents after preterm birth. METHODS: As part of the longitudinal HaFEn-study, data from parents of infants with very low birth weight (VLBW), and term infants were cross-sectionally analyzed. We recruited parents at the three largest perinatal care centers in Hamburg, Germany...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679622/pharmacotherapy-for-hyperglycemia-in-pregnancy-do-oral-agents-have-a-place
#2
REVIEW
Rosa Corcoy, Montserrat Balsells, Apolonia García-Patterson, Anat Shmueli, Eran Hadar
Diabetes is a frequent condition in pregnancy and achieving adequate glycemic control is of paramount importance. Insulin treatment is the gold standard, oral agents are more attractive, but their safety and efficiency should be a prerequisite for their use. We have more information regarding treatment of women with gestational diabetes mellitus where glyburide can induce a picture of fetal hyperinsulinism (higher birthweight and more neonatal hypoglycemia) whereas metformin requires supplemental insulin in a larger proportion of women but achieves satisfactory perinatal outcomes with the exception of preterm birth...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673373/chorioamnionitis-neuroinflammation-and-injury-timing-is-key-in-the-preterm-ovine-fetus
#3
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp, Suhas G Kallapur, Luc J Zimmermann, Per T Sangild, Stanislava Pankratova, Pierre Gressens, Boris W Kramer, Bobbi Fleiss, Tim G A M Wolfs
BACKGROUND: Antenatal infection (i.e., chorioamnionitis) is an important risk factor for adverse neurodevelopmental outcomes after preterm birth. Destructive and developmental disturbances of the white matter are hallmarks of preterm brain injury. Understanding the temporal effects of antenatal infection in relation to the onset of neurological injury is crucial for the development of neurotherapeutics for preterm infants. However, these dynamics remain unstudied. METHODS: Time-mated ewes were intra-amniotically injected with lipopolysaccharide at 5, 12, or 24 h or 2, 4, 8, or 15 days before preterm delivery at 125 days gestational age (term ~ 150 days)...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29672989/a-novel-model-to-study-neonatal-escherichia-coli-sepsis-and-the-effect-of-treatment-on-the-human-immune-system-using-humanized-mice
#4
Florian Schlieckau, Daniela Schulz, Sara Fill Malfertheiner, Kathrin Entleutner, Birgit Seelbach-Goebel, Wolfgang Ernst
PROBLEM: Neonatal sepsis is a serious threat especially for preterm infants. As existing in vitro and in vivo models have limitations, we generated a novel neonatal sepsis model using humanized mice and tested the effect of Betamethasone and Indomethacin which are used in the clinic in case of premature birth. METHOD OF STUDY: Humanized mice were infected with Escherichia coli (E. coli). Subsequently, the effect of the infection itself, and treatment with Betamethasone and Indomethacin on survival, recovery, bacterial burden, leukocyte populations, and cytokine production, was analyzed...
April 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29670470/maternal-plasma-metabolomic-profiles-in-spontaneous-preterm-birth-preliminary-results
#5
Barbara Lizewska, Joanna Teul, Pawel Kuc, Adam Lemancewicz, Karol Charkiewicz, Joanna Goscik, Marian Kacerovsky, Ramkumar Menon, Wojciech Miltyk, Piotr Laudanski
Objective: To profile maternal plasma metabolome in spontaneous preterm birth. Method: In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy ( n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy ( n = 49)), and with term delivery ( n = 25). Plasma samples were analysed using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) in positive and negative polarity modes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670041/comparative-evaluation-of-arabin-pessary-and-cervical-cerclage-for-the-prevention-of-preterm-labor-in-asymptomatic-women-with-high-risk-factors
#6
Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
OBJECTIVE: Preterm labor is one of the most significant obstetric problems associated with high rate of actual and long-term perinatal complications. Despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction and prevention of preterm labor is still a matter of concern. The aim of this study was to examine cervical findings for the prediction and the comparative use of Arabin pessary or cerclage for the prevention of preterm birth in asymptomatic women with high risk factors for preterm labor...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29667718/trajectories-of-psychopathology-in-extremely-low-birth-weight-survivors-from-early-adolescence-to-adulthood-a-20-year-longitudinal-study
#7
Ryan J Van Lieshout, Mark A Ferro, Louis A Schmidt, Michael H Boyle, Saroj Saigal, Katherine M Morrison, Karen J Mathewson
BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g)...
April 18, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29666202/nutritional-role-of-amniotic-fluid-clues-from-infants-with-congenital-obstruction-of-the-digestive-tract
#8
Nigel J Hall, Melanie Drewett, David Burge
AIMS: To investigate the role played by amniotic fluid in late fetal nutrition by analysis of infants born with digestive tract atresia. METHODS: Birth weight (BW), gestational age and gender of infants born with oesophageal (OA), duodenal (DA), jejunal (JA) and ileal atresia (IA) were recorded and BW Z-scores compared. Infants with incomplete obstruction (stenosis), chromosomal or syndromic conditions and multiple congenital malformations were excluded. Term infants admitted with suspected postnatal intestinal obstruction in whom no congenital malformation was found were used as a control group...
April 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29662257/17-hydroxiprogesterone-values-in-healthy-preterm-infants
#9
Víctor Clemente Mendoza-Rojas, Luis Alfonso Díaz-Martínez, Gerardo Mantilla-Mora, Gustavo Adolfo Contreras-García, Víctor Manuel Mora-Bautista, Jhon Freddy Martínez-Paredes, Alba Luz Calderón-Rojas, Carlos Augusto Gómez-Tarazona, Katherine Pinzón-Mantilla
Introduction: In preterm newborn, problems with the interpretation of 17-OHP may occur. Objective: Evaluate 17-OHP values in healthy preterm newborns until they reach the corrected gestational age. Methods: Longitudinal study of 36 preterm infants with 17-OHP evaluation using ELISA from heel blood from 3 to 5 days and thereafter every 2 weeks until the corrected gestational age. Values adjusting multiple variables such as gestational age, birth weight and sex, among others were compared...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29660514/early-life-predictors-of-brain-development-at-term-equivalent-age-in-infants-born-across-the-gestational-age-spectrum
#10
REVIEW
Deanne K Thompson, Claire E Kelly, Jian Chen, Richard Beare, Bonnie Alexander, Marc L Seal, Katherine Lee, Lillian G Matthews, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong
BACKGROUND: It is well established that preterm infants have altered brain development compared with full-term (FT; ≥37 weeks' gestational age [GA]) infants, however the perinatal factors associated with brain development in preterm infants have not been fully elucidated. In particular, perinatal predictors of brain development may differ between very preterm infants (VP; <32 weeks' GA) and infants born moderate (MP; 32-33 weeks' GA) and late (LP; 34-36 weeks' GA) preterm, but this has not been studied...
April 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29659125/extremely-preterm-children-exhibit-increased-interhemispheric-connectivity-for-language-findings-from-fmri-constrained-meg-analysis
#11
Maria E Barnes-Davis, Stephanie L Merhar, Scott K Holland, Darren S Kadis
Children born extremely preterm are at significant risk for cognitive impairment, including language deficits. The relationship between preterm birth and neurological changes that underlie cognitive deficits is poorly understood. We use a stories-listening task in fMRI and MEG to characterize language network representation and connectivity in children born extremely preterm (n = 15, <28 weeks gestation, ages 4-6 years), and in a group of typically developing control participants (n = 15, term birth, 4-6 years)...
April 16, 2018: Developmental Science
https://www.readbyqxmd.com/read/29658461/-monitoring-of-kidney-injury-in-preterm-infants
#12
Rong Zhang, Wen-Bin Dong
Acute kidney injury (AKI) is a common complication in the neonatal intensive care unit that causes a high mortality of preterm infants and various chronic kidney diseases in adulthood. Preterm infants have immature development of the kidneys at birth. The kidneys continue to develop within a specific time window after birth. However, due to various factors during pregnancy and after birth, preterm infants tend to develop AKI. At present, serum creatinine and urine volume are used for the assessment of kidney injury, and their early sensitivity and specificity have attracted increasing attention...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29658450/-influence-of-acute-pancreatitis-in-pregnancy-on-pregnancy-outcomes-and-neonates
#13
Shu-Juan Fan, Jun-Xi Xiang, Mi Xiao, Fang-Hui Wang, Xiao-Jie Lin, Xi-Hui Zhou, Ting Ai, Li Liu
OBJECTIVE: To study the influence of acute pancreatitis in pregnancy (APIP) on pregnancy outcomes and neonates. METHODS: A retrospective analysis was performed for 33 APIP patients and 31 neonates born alive. RESULTS: Of the 33 APIP patients, 26 (79%) developed APIP in the late pregnancy. Fourteen (45%) patients had hyperlipidemic APIP, 13 (42%) had biliary APIP, and 4 (13%) had other types of APIP. According to the severity, 22 (67%) were mild APIP, 5 (15%) were moderate APIP, and 6 were severe APIP...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29658448/-clinical-features-and-prognosis-of-preterm-infants-with-varying-degrees-of-bronchopulmonary-dysplasia
#14
Wen-Li Li, Fa-Lin Xu, Ming Niu, Meng-Di Liu, Hui-Fang Dong
OBJECTIVE: To study the clinical features and prognosis of preterm infants with varying degrees of bronchopulmonary dysplasia (BPD). METHODS: The clinical data of 144 preterm infants with a gestational age of <32 weeks who were admitted to the neonatal intensive care unit from March 2014 to March 2016 and were diagnosed with BPD were collected. According to the severity of BPD, these preterm infants were divided into mild group with 81 infants and moderate/severe group with 63 infants...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29651255/sex-specific-skeletal-muscle-fatigability-and-decreased-mitochondrial-oxidative-capacity-in-adult-rats-exposed-to-postnatal-hyperoxia
#15
Laura H Tetri, Gary M Diffee, Gregory P Barton, Rudolf K Braun, Hannah E Yoder, Kristin Haraldsdottir, Marlowe W Eldridge, Kara N Goss
Premature birth affects more than 10% of live births, and is characterized by relative hyperoxia exposure in an immature host. Long-term consequences of preterm birth include decreased aerobic capacity, decreased muscular strength and endurance, and increased prevalence of metabolic diseases such as type 2 diabetes mellitus. Postnatal hyperoxia exposure in rodents is a well-established model of chronic lung disease of prematurity, and also recapitulates the pulmonary vascular, cardiovascular, and renal phenotype of premature birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29649829/relation-of-retinopathy-of-prematurity-to-brain-volumes-at-term-equivalent-age-and-developmental-outcome-at-2-years-of-corrected-age-in-very-preterm-infants
#16
Kristbjörg Sveinsdóttir, David Ley, Holger Hövel, Vineta Fellman, Petra S Hüppi, Lois E H Smith, Ann Hellström, Ingrid Hansen Pupp
BACKGROUND: Retinopathy of prematurity (ROP) is a major complication of preterm birth and has been associated with later visual and nonvisual impairments. OBJECTIVES: To evaluate relationships between any stage of ROP, brain volumes, and developmental outcomes. METHODS: This study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age...
April 12, 2018: Neonatology
https://www.readbyqxmd.com/read/29649318/confined-placental-mosaicism-revisited-impact-on-pregnancy-characteristics-and-outcome
#17
Jérôme Toutain, Damien Goutte-Gattat, Jacques Horovitz, Robert Saura
OBJECTIVES: We wanted to re-evaluate the influence of confined placental mosaicism subtypes (type 2 and type 3) on pregnancy characteristics and outcome. MATERIAL AND METHODS: From July 2009 to December 2015, 5512 chorionic villus samplings were performed in our Fetal Medicine Center. Conventional karyotyping was performed after long-term and short-term cultured villi to define type 2 or type 3 confined placental mosaicisms. Karyotype after amniocentesis was performed to exclude true fetal mosaicism, when appropriate...
2018: PloS One
https://www.readbyqxmd.com/read/29649290/the-contribution-of-gestational-age-area-deprivation-and-mother-s-country-of-birth-to-ethnic-variations-in-infant-mortality-in-england-and-wales-a-national-cohort-study-using-routinely-collected-data
#18
Yangmei Li, Maria A Quigley, Nirupa Dattani, Ron Gray, Hiranthi Jayaweera, Jennifer J Kurinczuk, Alison Macfarlane, Jennifer Hollowell
OBJECTIVES: We aimed to describe ethnic variations in infant mortality and explore the contribution of area deprivation, mother's country of birth, and prematurity to these variations. METHODS: We analyzed routine birth and death data on singleton live births (gestational age≥22 weeks) in England and Wales, 2006-2012. Infant mortality by ethnic group was analyzed using logistic regression with adjustment for sociodemographic characteristics and gestational age...
2018: PloS One
https://www.readbyqxmd.com/read/29642747/elevated-maternal-serum-free-%C3%AE-human-chorionic-gonadotropin-%C3%AE-hcg-and-reduced-risk-of-spontaneous-preterm-delivery
#19
Shelly Soni, David A Krantz, Matthew J Blitz, Nidhi Vohra, Burton Rochelson
OBJECTIVE: To evaluate the relationship between first and second trimester maternal serum-free β-hCG and the risk of spontaneous preterm delivery (PTD). STUDY DESIGN: This was a case-control study of women evaluated and delivered at our institution from 2011 to 2015. Spontaneous PTD was defined as delivery before 37 weeks due to spontaneous preterm labor or premature rupture of membranes. Patient with multifetal gestation and those with medically indicated term or PTD were excluded...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29642740/maternal-periodontal-disease-and-adverse-perinatal-outcomes-is-there-an-association-a-hospital-based-case-control-study
#20
Marta Silveira da Mota Krüger, Renata Picanço Casarin, Gabriela Dos Santos Pinto, Fernanda Geraldo Pappen, Maria Beatriz Junqueira Camargo, Fernanda Oliveira Bello Correa, Ana Regina Romano
OBJECTIVES: The association between maternal periodontal disease and adverse perinatal outcomes although extensively studied remains unclear. The aim of this study was to evaluate, by a case-control study, conducted in three hospitals the association between preterm birth and/or low birth weight (PTB/LBW) and clinical parameters of maternal periodontal disease. MATERIAL AND METHODS: Postpartum women who gave birth to a newborn PTB/LBW (case group), and postpartum women who had babies at full term with normal weight (control group) were included, in 1:2 ratio...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
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