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https://www.readbyqxmd.com/read/29221766/screening-for-fetal-growth-restriction-and-placental-insufficiency
#1
REVIEW
Melanie C Audette, John C Kingdom
Fetal growth restriction (FGR) continues to be a leading cause of preventable stillbirth and poor neurodevelopmental outcomes in offspring, and furthermore is strongly associated with the obstetrical complications of iatrogenic preterm birth and pre-eclampsia. The terms small for gestational age (SGA) and FGR have, for too long, been considered equivalent and therefore used interchangeably. However, the delivery of improved clinical outcomes requires that clinicians effectively distinguish fetuses that are pathologically growth-restricted from those that are constitutively small...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29215527/long-term-trends-in-singleton-preterm-birth-in-south-australia-from-1986-to-2014
#2
Petra E Verburg, Gus A Dekker, Kamalesh Venugopal, Wendy Scheil, Jan Jaap H M Erwich, Ben W Mol, Claire T Roberts
OBJECTIVE: To describe long-term trends in the prevalence of preterm birth and rates of preterm birth in singleton pregnancies complicated by hypertensive disorders of pregnancy, small for gestational age (SGA), and preterm prelabor rupture of membranes (PROM) in South Australia. METHODS: We conducted a retrospective population study including all singleton live births in the state of South Australia from 1986 to 2014. Long-term trends for preterm birth, hypertensive disorders of pregnancy, SGA, preterm PROM as well as stillbirth were assessed using joinpoint regression analyses...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29214412/gestational-age-at-birth-and-risk-of-intellectual-disability-without-a-common-genetic-cause
#3
Hein Heuvelman, Kathryn Abel, Susanne Wicks, Renee Gardner, Edward Johnstone, Brian Lee, Cecilia Magnusson, Christina Dalman, Dheeraj Rai
Preterm birth is linked to intellectual disability and there is evidence to suggest post-term birth may also incur risk. However, these associations have not yet been investigated in the absence of common genetic causes of intellectual disability, where risk associated with late delivery may be preventable. We therefore aimed to examine risk of intellectual disability without a common genetic cause across the entire range of gestation, using a matched-sibling design to account for unmeasured confounding by shared familial factors...
December 6, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29214043/folic-acid-level-and-preterm-birth-among-sudanese-women
#4
Manal E Sharif, Ahmed Mohamedain, AbdelBagi A Ahmed, Abubakr M Nasr, Ishag Adam
Background: Preterm birth (PTB) is the major health problem world-wide; there are few published studies on PTB and folic acid. Methods: The study was conducted to assess the serum level of folic acid in PTB. A case-control study was conducted at Saad Abualila maternity hospital (Khartoum, Sudan) during the period of March through December 2015. Women who delivered live singleton babies were dived in two groups; the cases were women who had PTB "delivery before completed 37weeks but after 24 weeks of pregnancy" and the controls were women who delivered at term (37-42 weeks)...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29212618/altered-cerebral-perfusion-in-infants-born-preterm-compared-with-infants-born-full-term
#5
Marine Bouyssi-Kobar, Jonathan Murnick, Marie Brossard-Racine, Taeun Chang, Eman Mahdi, Marni Jacobs, Catherine Limperopoulos
OBJECTIVES: To compare regional cerebral cortical blood flow (CBF) in infants born very preterm at term-equivalent age (TEA) and healthy newborns born full term and to examine the impact of clinical risk factors on CBF in the cohort born preterm. STUDY DESIGN: This prospective, cross-sectional study included infants born very preterm (gestational age at birth <32 weeks; birth weight <1500 g) and healthy infants born full term. Using noninvasive 3T arterial spin labeling magnetic resonance imaging, we quantified regional CBF in the cerebral cortex: sensorimotor/auditory/visual cortex, superior medial/dorsolateral prefrontal cortex, anterior cingulate cortex (ACC)/posterior cingulate cortex, insula, and lateral posterior parietal cortex, as well as in the brainstem, and deep gray matter...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29211491/complications-and-care-related-to-pregnancy-labor-and-delivery-among-active-component-service-women-u-s-armed-forces-2012-2016
#6
Shauna Stahlman, Catherine T Witkop, Leslie L Clark, Stephen B Taubman
Diagnoses of "complications of pregnancy, childbirth, and the puerperium" include both morbid complications and indications for routine care of pregnant women. During 2012-2016, a total of 55,601 U.S. service members with live births (n=63,879) had 657,060 medical encounters with primary diagnoses of "pregnancy complications." The most frequent diagnoses were "other" specified conditions complicating pregnancy, childbirth, or the puerperium. Numbers of medical encounters with a primary (first-listed) diagnosis of any pregnancy-related complication or indication for care decreased marginally each year between 2012 (n=178,703) and 2016 (n=146,282)...
November 2017: MSMR
https://www.readbyqxmd.com/read/29210924/intraventricular-hemorrhage-in-moderate-to-severe-congenital-heart-disease
#7
Cynthia M Ortinau, Jagruti S Anadkat, Christopher D Smyser, Pirooz Eghtesady
OBJECTIVES: Determine the prevalence of intraventricular hemorrhage in infants with moderate to severe congenital heart disease, investigate the impact of gestational age, cardiac diagnosis, and cardiac intervention on intraventricular hemorrhage, and compare intraventricular hemorrhage rates in preterm infants with and without congenital heart disease. DESIGN: A single-center retrospective review. SETTING: A tertiary care children's hospital...
November 28, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29208241/increased-trophoblast-inclusions-in-placentas-from-prematurely-born-infants-a-potential-marker-of-risk-for-preterm-neurodevelopmental-outcomes
#8
Morgan R Firestein, Rosanna Abellar, Michael M Myers, Martha G Welch
Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2-8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a ∼4 fold increase in the frequency of TIs (30.5%). Frequency of TIs was inversely related to gestational age (GA); 43% of placentas <30 weeks and 20% of placentas ≥32 weeks had TIs (χ2 = 4.41, p = 0.036). This increased prevalence in preterm infants suggests that TIs may indicate adverse intrauterine processes or undetected genetic abnormalities and could identify infants at risk for poor neurodevelopment...
December 2017: Placenta
https://www.readbyqxmd.com/read/29207479/growth-and-bone-mineralization-of-very-preterm-infants-at-term-corrected-age-in-relation-to-different-nutritional-intakes-in-the-early-postnatal-period
#9
Michelle N Körnmann, Viola Christmann, Charlotte J W Gradussen, Laura Rodwell, Martin Gotthardt, Johannes B Van Goudoever, Arno F J Van Heijst
Preterm infants often have a reduced bone mineral content (BMC) with increased risk of metabolic bone disease. After birth it is difficult to supply calcium (Ca) and phosphorus (P) comparable to the high fetal accretion rate. It is not known whether high supplementation of minerals in the early postnatal period improves growth and bone mineralization. The aim of this study was to evaluate growth and bone mineralization at term corrected age (TCA) in very and extremely preterm infants who received different enteral Ca and P intakes during the first 10 days of life...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29206936/birthweight-of-singletons-born-after-cleavage-stage-or-blastocyst-transfer-in-fresh-and-warming-cycles
#10
Anick De Vos, Samuel Santos-Ribeiro, Lisbet Van Landuyt, Hilde Van de Velde, Herman Tournaye, Greta Verheyen
STUDY QUESTION: Does extended culture to the blastocyst stage affect singleton birthweight after either fresh or vitrified-warmed embryo transfer? SUMMARY ANSWER: Singleton birthweight z-scores did not vary significantly after a fresh blastocyst transfer, whereas the additional effect of vitrification remains inconclusive. WHAT IS KNOWN ALREADY: Observational studies have associated extended culture with an increased risk of preterm birth and low birthweight...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29205640/presepsin-as-a-predictor-of-positive-blood-culture-among-newborns-suspected-sepsis
#11
Yukihide Miyosawa, Yohei Akazawa, Motoko Kamiya, Chizuko Nakamura, Yusuke Takeuchi, Mai Kusakari, Tomohiko Nakamura
BACKGROUND: Although the incidence of neonatal sepsis is decreasing, neonatal sepsis remains a severe life-threatening disease. No current biochemical marker can provide perfect diagnostic accuracy for neonatal sepsis. OBJECTIVES: We evaluated the accuracy of presepsin (P-SEP) as a novel biomarker of bacterial infection for neonatal sepsis diagnosis. METHODS: We prospectively studied newborns with sepsis (sepsis group n=13) during the first 30 days after birth and compared them with control preterm newborns (control group n=18)...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29205635/cerebral-white-matter-maturation-patterns-in-preterm-infants-an-mri-t2-relaxation-anisotropy-and-diffusion-tensor-imaging-study
#12
Michael J Knight, Adam Smith-Collins, Sarah Newell, Mark Denbow, Risto A Kauppinen
BACKGROUND AND PURPOSE: Preterm birth is associated with worse neurodevelopmental outcome, but brain maturation in preterm infants is poorly characterized with standard methods. We evaluated white matter (WM) of infant brains at term-equivalent age, as a function of gestational age at birth, using multimodal magnetic resonance imaging (MRI). METHODS: Infants born very preterm (<32 weeks gestation) and late preterm (33-36 weeks gestation) were scanned at 3 T at term-equivalent age using diffusion tensor imaging (DTI) and T2 relaxometry...
December 5, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29205573/serum-relaxin-and-cervical-length-for-the-prediction-of-spontaneous-preterm-birth-in-second-trimester-symptomatic-women
#13
Athanasios Pantelis, Alexandros Sotiriadis, Kimon Chatzistamatiou, Georgios Pratilas, Konstantinos Dinas
OBJECTIVE: to investigate whether serum relaxin is associated with preterm birth in symptomatic women, either as a standalone test or in the context of a combined model. METHODS: This was a case-control study of women with singleton pregnancy, who presented between 24+0 and 26+6 weeks with threatened preterm labor and intact membranes. Cervical length, full blood count, C-reactive protein and maternal demographics were recorded at presentation. Blood samples were taken for relaxin and these parameters were compared between women who delivered <37 weeks (N=46) and women delivering at term (N=66)...
December 5, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29204660/association-of-age-with-risk-of-hospitalization-for-respiratory-syncytial-virus-in-preterm-infants-with-chronic-lung-disease
#14
Almut G Winterstein, Yoonyoung Choi, H Cody Meissner
Importance: It is unknown whether the age threshold (≤24 months) for preterm infants with chronic lung disease (CLD) to receive immunoprophylaxis for respiratory syncytial virus (RSV) as currently recommended by American Academy of Pediatrics guidelines correctly identified infants at higher risk for hospitalization for RSV. Objective: To determine the age when the risk of hospitalization for RSV among preterm infants with CLD becomes equivalent to the risk for healthy, 1-month-old term infants who do not qualify for immunoprophylaxis...
December 4, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29203503/multicentre-prospective-randomised-single-blind-controlled-study-protocol-of-the-effect-of-an-additional-parent-administered-sensorimotor-stimulation-on-neurological-development-of-preterm-infants-primebrain
#15
Karine Pelc, Irit Daniel, Bernard Wenderickx, Bernard Dan
INTRODUCTION: Preterm and very low birthweight infants are at increased risk for neurodevelopmental disorders, including cerebral palsy, sensory impairment and intellectual disability. Several early intervention approaches have been designed in the hope of optimising neurological development in this context. It seems important that the intervention takes into account parental mental health, focuses on parent-child interactions and lasts sufficiently long. This study aims to evaluate the effects of a stimulation programme administered by parents until 6 months post-term on motor and neurophysiological development of infants born preterm...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29202809/five-years-follow-up-of-dental-fear-and-anxiety-experience-of-dental-care-and-oral-health-behaviour-in-swedish-preterm-and-full-term-adolescents
#16
Susanne Brogårdh-Roth, Johanna Månsson, Karin Ridell, Lubna Alward, Kristina Hellén-Halme, EwaCarin Ekberg
BACKGROUND: There is rising concern about how preterm birth affects long-term health later in life. The various effects that preterm birth have on developmental outcomes, cognitive profiles and medical health may also affect levels of cooperation in the dental care situation in addition to general oral health and other oral health-related habits. Oral health is an integral part of one's general health and well-being; however, less is known about how prematurity affects oral health and other related areas such as dental care, and including dental fear and anxiety (DFA) in individuals during adolescence and adulthood...
December 4, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29198539/long-term-outcomes-of-hyperglycemic-preterm-infants-randomized-to-tight-glycemic-control
#17
Anna Catherine Tottman, Jane Marie Alsweiler, Frank Harry Bloomfield, Greg Gamble, Yannan Jiang, Myra Leung, Tanya Poppe, Benjamin Thompson, Trecia Ann Wouldes, Jane Elizabeth Harding
OBJECTIVE: To determine whether tight glycemic control of neonatal hyperglycemia changes neurodevelopment, growth, and metabolism at school age. STUDY DESIGN: Children born very low birth weight and randomized as hyperglycemic neonates to a trial of tight vs standard glycemic control were assessed at 7 years corrected age, including Wechsler Intelligence Scale for Children Fourth Edition, Movement Assessment Battery for Children 2, visual and neurologic examinations, growth measures, dual X-ray absorptiometry, and frequently sampled intravenous glucose tolerance test...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29197374/prevalence-and-associated-factors-of-strabismus-in-former-preterm-and-full-term-infants-between-4-and-10%C3%A2-years-of-age
#18
Achim Fieß, Ruth Kölb-Keerl, Alexander K Schuster, Markus Knuf, Bernd Kirchhof, Philipp S Muether, Jacqueline Bauer
BACKGROUND: Limited data exist collating most of the associated factors for strabismus in one analysis. The aim of this study was to assess the prevalence of strabismus and to analyse associated factors in former preterm and full-term infants. METHODS: In this cross-sectional study, 239 former preterm infants with gestational age (GA) ≤ 32 weeks and 264 former full-term born infants with GA ≥ 37 weeks underwent detailed ophthalmologic examination in the age of 4-10 years and perinatal data assessment for risk factor analysis...
December 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29197251/-the-next-generation-long-term-reproductive-outcome-of-adults-born-at-a-very-low-birth-weight
#19
Lior Drukker, Ziona Haklai, Mor Ben-Yair Schlesinger, Maayan Bas-Lando, Ethel Sherry Gordon, Arnon Samueloff, Michael S Schimmel, Sorina Grisaru-Granovsky
BACKGROUND: Preterm birth at very low birth weight (VLBW, <1500g) has a multitude of consequences that extend to various aspects of adult life. Little is known about the long-term reproductive outcome of VLBW that survive to adulthood. AIMS: To evaluate the reproductive outcome of VLBW infants who survive to adulthood (next-generation). STUDY DESIGN: Retrospective cohort. SUBJECTS: Infants born at a single tertiary center between the years 1982-1997 who survived to 18years of age (first-generation)...
November 29, 2017: Early Human Development
https://www.readbyqxmd.com/read/29196505/trends-in-executive-functioning-in-extremely-preterm-children-across-3-birth-eras
#20
Alice C Burnett, Peter J Anderson, Katherine J Lee, Gehan Roberts, Lex W Doyle, Jeanie L Y Cheong
BACKGROUND AND OBJECTIVES: To determine if executive functioning outcomes at school age are different for extremely preterm (EP; <28 weeks' gestation) or extremely low birth weight (ELBW; <1000 g birth weight) children born in 1991 to 1992, 1997, and 2005 relative to their term-born peers. METHODS: Population-based cohorts of all EP/ELBW survivors born in the state of Victoria, Australia, in 1991 to 1992, 1997, and 2005, and contemporaneous controls (matched for expected date of birth, sex, mother's country of birth [English speaking or not], and health insurance status) were recruited at birth...
December 1, 2017: Pediatrics
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