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preterm and term birth

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https://www.readbyqxmd.com/read/28822226/perinatal-outcomes-after-previable-preterm-premature-rupture-of-membranes-before-24-weeks-of-gestation
#1
Verena Kiver, Vinzenz Boos, Anke Thomas, Wolfgang Henrich, Alexander Weichert
OBJECTIVE: A current descriptive assessment of perinatal outcomes in pregnancies complicated by previable preterm premature rupture of membranes (pPPROM) at <24 weeks of gestation, after expectant treatment. STUDY DESIGN: Maternal and short-term neonatal data were collected for patients with pPPROM. RESULTS: Seventy-three patients with 93 fetuses were hospitalized with pPPROM at 15-24 weeks' gestation. Among these patients, 27.4% (n=20) chose pregnancy termination, 27...
August 19, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28820869/necrotizing-enterocolitis-and-high-intestinal-iron-uptake-due-to-genetic-variants
#2
Wolfgang Göpel, Josephine Drese, Tanja K Rausch, Nele Twisselmann, Bettina Bohnhorst, Andreas Müller, Axel Franz, Andreas Ziegler, Christoph Härtel, Egbert Herting
BACKGROUND: Intestinal iron is a nutritional compound, which is essential for enteric microbiota. We evaluated the hypothesis that polymorphisms which are known modifiers of intestinal iron uptake in adults are associated with necrotizing enterocolitis (NEC) in preterm infants. METHODS: Preterm infants (birth weight below 1,500 grams) were studied. Single nucleotide polymorphisms with known effects on serum iron levels (rs1800562, rs1799945, rs855791) were determined by polymerase chain reaction...
August 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28819030/estimates-of-burden-and-consequences-of-infants-born-small-for-gestational-age-in-low-and-middle-income-countries-with-intergrowth-21-st-standard-analysis-of-cherg%C3%A2-datasets
#3
Anne Cc Lee, Naoko Kozuki, Simon Cousens, Gretchen A Stevens, Hannah Blencowe, Mariangela F Silveira, Ayesha Sania, Heather E Rosen, Christentze Schmiegelow, Linda S Adair, Abdullah H Baqui, Fernando C Barros, Zulfiqar A Bhutta, Laura E Caulfield, Parul Christian, Siân E Clarke, Wafaie Fawzi, Rogelio Gonzalez, Jean Humphrey, Lieven Huybregts, Simon Kariuki, Patrick Kolsteren, John Lusingu, Dharma Manandhar, Aroonsri Mongkolchati, Luke C Mullany, Richard Ndyomugyenyi, Jyh Kae Nien, Dominique Roberfroid, Naomi Saville, Dianne J Terlouw, James M Tielsch, Cesar G Victora, Sithembiso C Velaphi, Deborah Watson-Jones, Barbara A Willey, Majid Ezzati, Joy E Lawn, Robert E Black, Joanne Katz
Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21(st) birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestational age, birth weight, and neonatal follow-up. Small for gestational age was defined as infants weighing less than the 10th centile birth weight for gestational age and sex with the multiethnic, INTERGROWTH-21(st) birth weight standard...
August 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28818072/use-of-hospital-based-health-care-services-among-children-aged-1-through-9%C3%A2-years-who-were-born-very-preterm-a-population-based-study
#4
Søren T Klitkou, Tor Iversen, Hans J Stensvold, Arild Rønnestad
BACKGROUND: Very preterm (VPT) children, with a birth weight below 1500 g or delivered before 32 weeks of gestational age, are at increased risk of poorer long-term health outcomes and higher rates of hospitalization in childhood. However, considerable variation exists in the need for in-hospital care within this population. We assessed the utilization and distribution of hospital-based care from ages 1 through 9 years for a nationwide population. METHODS: This was a population-based cohort of VPT children born in the period 2001-2009...
August 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28816393/sperm-donation-perinatal-outcomes-in-an-australian-population-cohort
#5
Damian Adams, Renae Fernandez, Vivienne Moore, Kristyn Willson, Alice Rumbold, Sheryl de Lacey, Wendy Scheil, Michael Davies
AIM: To compare perinatal outcomes for neonates conceived with donated sperm with those for neonates conceived spontaneously in an Australian population cohort. METHODS: Perinatal outcomes for all births in South Australia for the period January 1986-December 2002 were linked with assisted reproductive treatment records to determine those conceived from donated sperm. Birth outcome measures were analyzed using Student's t-test and logistic regression using generalized estimating equations to determine statistical significance...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28814550/changing-neurodevelopment-at-8-years-in-children-born-extremely-preterm-since-the-1990s
#6
Jeanie L Y Cheong, Peter J Anderson, Alice C Burnett, Gehan Roberts, Noni Davis, Leah Hickey, Elizabeth Carse, Lex W Doyle
BACKGROUND AND OBJECTIVE: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. METHODS: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28814424/hospitalisation-of-preterm-infants-with-pertussis-in-the-context-of-a-maternal-vaccination-programme-in-england
#7
Lisa Byrne, Helen Campbell, Nick Andrews, Sonia Ribeiro, Gayatri Amirthalingam
AIMS: To assess whether preterm infants are at increased risk of pertussis infection and whether this increased following introduction of a maternal pertussis vaccination in England, while examining characteristics of infants associated with more severe disease. METHODS: Infants aged <60 days admitted between 1 April 2009 and 31 March 2016 with a pertussis diagnosis code were extracted from Hospital Episode Statistics (HES) data. HES data were reconciled with existing surveillance systems to capture maternal vaccination status where available...
August 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28811513/altered-cerebellar-biochemical-profiles-in-infants-born-prematurely
#8
Marie Brossard-Racine, Jonathan Murnick, Marine Bouyssi-Kobar, Janie Coulombe, Taeun Chang, Catherine Limperopoulos
This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy ((1)H-MRS). We explore the associations between altered cerebellar metabolite profiles and brain injury topography, severity of injury, and prematurity-related clinical complications. We prospectively collected high quality (1)H-MRS in 59 premature infants born ≤32 weeks and 61 healthy full term controls. (1)H-MRS data were processed using LCModel software to calculate absolute metabolite concentration for N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811156/screening-of-congenital-hypothyroidism-in-preterm-low-birth-weight-and-very-low-birth-weight-neonates-a-systematic-review
#9
REVIEW
Mahin Hashemipour, Silva Hovsepian, Arman Ansari, Mojtaba Keikha, Pooyan Khalighinejad, Negar Niknam
Evidence from different screening programs indicated that the rate of congenital hypothyroidism (CH) was higher in pre-term and low-birth-weight (LBW) newborns than normal ones. Incomplete development of hypothalamic-pituitary axis in this group of neonates results in the delayed rise of TSH and missing cases with CH. Hence, there is a great need for a practicable systematic screening method for proper diagnosis of CH in this group of neonates. In this review, we systematically reviewed papers with the following key words ([Congenital Hypothyroidism AND Screening AND Thyroxine AND Thyroid Stimulating Hormone AND Low Birth Weight AND Premature]) in international electronic databases including PubMed, Scopus, and Google Scholar...
July 22, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28810692/resveratrol-protects-from-lipopolysaccharide-induced-inflammation-in-the-uterus-and-prevents-experimental-preterm-birth
#10
María Victoria Bariani, Fernando Correa, Emma Leishman, Ana Paula Domínguez Rubio, Andreína Arias, Aníbal Stern, Heather B Bradshaw, Ana María Franchi
STUDY QUESTION: Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? SUMMARY ANSWER: Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. WHAT IS KNOWN ALREADY: Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28807607/plasma-cell-and-serum-antibody-responses-to-influenza-vaccine-in-preterm-and-full-term-infants
#11
Carl T D'Angio, Claire P Wyman, Ravi S Misra, Jessica L Halliley, Hongyue Wang, Julianne E Hunn, Caitlin M Fallone, F Eun-Hyung Lee
BACKGROUND: Preterm (PT) infants are at greater risk for severe influenza infection and experience decrements in long-term antibody responses to vaccines. This may related to defects in antibody secreting cell (ASC) generation. OBJECTIVE: To investigate the relationships among the frequencies of influenza-specific antibody secreting cells, ASC numbers and subsets, and antibody responses to influenza vaccines (IV) among PT and full-term (FT) infants. DESIGN/METHODS: We enrolled 11 former PT (≤32weeks' gestation, ≤1500 g' birth weight) and 11FT infants, 6-17months of age, receiving their first influenza immunizations...
August 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28805261/pregnancy-outcomes-and-impact-of-pregnancy-on-graft-function-in-women-after-kidney-transplantation
#12
Fa Mohammadi, M Borg, A Gulyani, S P Mcdonald, S Jesudason
BACKGROUND: Kidney transplantation facilitates pregnancy in women with end-stage kidney disease, however impact of pregnancy on short and longer-term graft function is uncertain. METHODS: Obstetric, foetal and graft outcomes for pregnancies from a large Australian transplant unit (1976-2015) were reviewed. RESULTS: There were 56 pregnancies in 35 women with mean age at conception 30.4±0.6 years and mean transplant-pregnancy interval 5.5±0...
August 14, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28805106/measuring-fetal-brain-and-lung-transcripts-in-amniotic-fluid-supernatant-a-comparison-of-digital-pcr-and-rt-qpcr-methods
#13
Lisa Hui, Sally Beard, Natalie J Hannan
PURPOSE: Amniotic fluid (AF) cell-free RNA is a promising source of information regarding fetal physiology. Digital PCR (dPCR) is a direct approach to nucleic acid detection that reports absolute transcript copy number. The aim of this study was to compare quantification of cell-free fetal brain and lung RNA transcripts in AF by reverse transcription-qPCR and dPCR. MATERIAL AND METHODS: Prospective hospital-based study performed in 2016-2017. Pulmonary genes were quantified in term AF samples collected at elective cesarean birth; neurodevelopmental genes were measured in preterm samples (< 34 weeks) obtained from women undergoing clinically-indicated amniocentesis...
August 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28804715/former-very-preterm-infants-show-alterations-in-thyroid-function-at-a-preschool-age
#14
Anna Posod, Irena Odri Komazec, Ulrike Pupp Peglow, Dagmar Meraner, Elke Griesmaier, Ursula Kiechl-Kohlendorfer
Preterm birth is frequently associated with altered thyroid hormone levels in the newborn period. Recent data suggest a role of prematurity independent of birth size also in childhood thyroid dysfunction. Whether the high-risk population of former very preterm infants (VPI) is particularly susceptible to thyroid hormone alterations is currently unknown. The aim of the present study was to assess whether former VPI display changes in thyroid hormone status in comparison to term-born controls at a preschool age...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28799276/mode-of-delivery-for-singleton-extreme-preterm-breech-fetuses-a-10%C3%A2-year-retrospective-review-from-a-single-tertiary-obstetric-centre
#15
Frances Hills, Mandy Way, Renuka Sekar
BACKGROUND: Preterm breech delivery is associated with a higher perinatal mortality rate compared with preterm vertex delivery, and some studies suggest caesarean section leads to lower mortality rates. Few studies include infants delivered less than 26 weeks gestation, and where included, results are often not stratified by gestational age. There is also a lack of consistent reporting on neonatal and maternal morbidity outcome measures. AIMS: To determine if mode of delivery for singleton extreme preterm breech fetuses is associated with a difference in perinatal mortality, neonatal and maternal morbidity...
August 11, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28798414/comparison-of-neonatal-outcomes-following-progesterone-use-during-ovarian-stimulation-with-frozen-thawed-embryo-transfer
#16
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798147/very-preterm-birth-and-parents-quality-of-life-27-years-later
#17
Dieter Wolke, Nicole Baumann, Barbara Busch, Peter Bartmann
BACKGROUND AND OBJECTIVES: Parents of preterm children experience increased distress early in their children's lives. Whether the quality of life of parents of preterm children is comparable to that of parents of term children by the time their offspring reach adulthood is unknown. What precursors in their offspring's childhood predict parental quality of life? METHODS: A prospective whole-population study in Germany followed very preterm (VP) (<32 weeks gestation) or very low birth weight (VLBW) (<1500 g) (N = 250) and term-born individuals (N = 230) and their parents (VP or VLBW: N = 219; term: N = 227) from birth to adulthood...
August 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28797126/development-of-salivary-cortisol-circadian-rhythm-in-preterm-infants
#18
Katrin Ivars, Nina Nelson, Annette Theodorsson, Elvar Theodorsson, Jakob O Ström, Evalotte Mörelius
OBJECTIVES: To investigate at what age preterm infants develop a salivary cortisol circadian rhythm and identify whether it is dependent on gestational age and/or postnatal age. To evaluate whether salivary cortisol circadian rhythm development is related to behavioral regularity. To elucidate salivary cortisol levels in preterm infants during the first year of life. METHODS: This prospective, longitudinal study included 51 preterm infants. 130 healthy full-term infants served as controls...
2017: PloS One
https://www.readbyqxmd.com/read/28796981/-infant-and-neonatal-deaths-in-poland-in-1995-2015
#19
Katarzyna Szamotulska, Ewa Mierzejewska
AIM: The aim of the study was the analysis of trends of infant and neonatal mortality in Poland in 1995-2015, overall and by gestational age, main groups of causes and age at death. MATERIAL AND METHODS: Data from birth and death certificates from 1995, 2000, 2005, 2010, 2014 and 2015 were used. Infant, neonatal, postneonatal, perinatal and gestational age - specific mortality rates were presented. Main groups of causes of deaths were determined according to the International Classification of Diseases ICD-10...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28794133/presence-and-pattern-of-scarring-in-children-born-very-preterm
#20
Anna C Tottman, Jane M Alsweiler, Frank H Bloomfield, Jane E Harding
The long-term scarring burden of preterm infants undergoing modern neonatal intensive care is not known. This observational cohort study aimed to document the presence and pattern of scarring in children born <30 weeks' gestation or <1500 g birth weight and cared for at the National Women's Health neonatal intensive care unit, Auckland, New Zealand. Children were examined at 7 years' corrected age and the presence, size, number and distribution of scars documented. Scarring was seen in 90% of 129 children assessed, with 81% having multiple scars, 60% having large scars (85% of whom had no history of major neonatal surgery) and 75% having more than one body area scarred...
August 9, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
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