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https://www.readbyqxmd.com/read/28103309/folate-transporters-in-placentas-from-preterm-newborns-and-their-relation-to-cord-blood-folate-and-vitamin-b12-levels
#1
Erika Castaño, Lorena Caviedes, Sandra Hirsch, Miguel Llanos, Germán Iñiguez, Ana María Ronco
Folate deficiency during pregnancy has been related to low birth weight, preterm (PT) birth and other health risks in the offspring; however, it is unknown whether prematurity is related to low folate transport through the placenta due to altered expression of specific folate transporters. We determined placental expression (mRNA and protein concentrations by RT-qPCR and WB respectively) of specific folate transporters: RFC, PCFT/HCP1 and FOLR1 in chorionic (fetal) and basal (maternal) plates of placentas of PT pregnancies (PT, 32-36 weeks, n = 51)...
2017: PloS One
https://www.readbyqxmd.com/read/28102852/anthropometric-trends-from-1997-to-2012-in-infants-born-at-%C3%A2-28-weeks-gestation-or-less
#2
N Wells, T A Stokes, K Ottolini, C H Olsen, A R Spitzer, C E Hunt
OBJECTIVE: Postnatal growth failure is common after preterm birth, in particular for infants born at ⩽28 weeks' gestation, but it is unknown if growth-to-term equivalent age has improved over the years as neonatal intensive care in general, and infant nutrition in particular, have improved. The objective of the study was to evaluate anthropometric trends at NICU discharge for infants born at ⩽28 weeks' gestation using a large national database. STUDY DESIGN: Analysis of growth in weight, length, head circumference and body mass index (kg m(2)) in 23 005 infants born in 1997 to 2012 who survived to neonatal intensive care unit discharge at ⩽41 weeks' postmenstrual age...
January 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28101838/renal-consequences-of-preterm-birth
#3
REVIEW
Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch, Abhay Lodha
BACKGROUND: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viability in premature infants have been pushed to lower gestational ages, the long-term impact of prematurity on kidneys still remains a significant burden during hospital stay and beyond. OBJECTIVES: The purpose of this study is to summarize available evidence, mechanisms, and short- and long-term renal consequences of prematurity and identify nephroprotective strategies and areas of uncertainty...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28100483/electrophysiological-changes-in-12-year-old-children-born-mlp-reduced-vep-amplitude-in-mlp-children
#4
Lina H Raffa, Josefin Nilsson, Jovanna Dahlgren, Marita Andersson Grönlund
AIM: To study the electrophysiological changes in relation to fundus morphology in moderate-to-late preterm (MLP) children with no previous history of retinopathy of prematurity. METHODS: Visual acuity (VA), refraction and fundus variables measured by optical coherence tomography, pattern reversal visual evoked potentials and full-field electroretinography (ff-ERG) were obtained from 22 twelve-year-old MLP children (11 male, 11 female) and 21 full-term controls...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28100316/optimizing-nutrition-of-the-preterm-infant
#5
William W Jr Hay
The goal of nutrition of the preterm infant is to meet the growth rate of the healthy fetus of the same gestational age and to produce the same body composition of the healthy fetus in terms of organ growth, tissue components, and cell number and structure. Nutritional quantity and quality are fundamental for normal growth and development of preterm infants, including neurodevelopmental outcomes. Failure to provide the necessary amounts of all of the essential nutrients has produced not only growth failure, but also increased morbidity and less than optimal neurodevelopment...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28098735/optical-coherence-tomography-angiography-of-the-fovea-in-children-born-preterm
#6
Khalil Ghasemi Falavarjani, Nicholas A Iafe, Federico G Velez, Steven D Schwartz, Srinivas R Sadda, David Sarraf, Irena Tsui
PURPOSE: To compare the foveal avascular zone (FAZ) area measured by optical coherence tomography angiography in children who had been born preterm with age-matched controls. METHODS: In this cross-sectional observational comparative case series, 43 eyes of 26 children (28 eyes of 15 former preterm infants and 15 eyes of 11 former term infants) between the ages of 4 and 12 years old were included. Optical coherence tomography angiography with a scan size of 3 × 3 was performed for all eyes...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098724/central-macular-thickness-in-6-5-year-old-children-born-extremely-preterm-is-strongly-associated-with-gestational-age-even-when-adjusted-for-risk-factors
#7
Anna E C Molnar, Rebecka M Rosén, Maria Nilsson, Eva K B Larsson, Gerd E Holmström, Kerstin M Hellgren
PURPOSE: To assess the macular thickness in 6.5-year-old children born extremely preterm (EPT) in comparison with children born at term and to investigate risk factors associated with the macular thickness in the preterm group. METHODS: A population-based study of 6.5-year-old children born before the gestational age of 27 weeks and age-matched control subjects. Macular assessments with optical coherence tomography were performed, and the results were compared with neonatal risk factors and sex...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28095889/evolution-of-gut-microbiota-composition-from-birth-to-24-weeks-in-the-infantmet-cohort
#8
Cian J Hill, Denise B Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B Jeffery, Carol Anne O'Shea, Claire Watkins, Eugene Dempsey, Fulvio Mattivi, Kieran Touhy, R Paul Ross, C Anthony Ryan, Paul W O' Toole, Catherine Stanton
BACKGROUND: The gut is the most extensively studied niche of the human microbiome. The aim of this study was to characterise the initial gut microbiota development of a cohort of breastfed infants (n = 192) from 1 to 24 weeks of age. METHODS: V4-V5 region 16S rRNA amplicon Illumina sequencing and, in parallel, bacteriological culture. The metabolomic profile of infant urine at 4 weeks of age was also examined by LC-MS. RESULTS: Full-term (FT), spontaneous vaginally delivered (SVD) infants' microbiota remained stable at both phylum and genus levels during the 24-week period examined...
January 17, 2017: Microbiome
https://www.readbyqxmd.com/read/28094234/association-between-preterm-labor-and-genitourinary-tract-infections-caused-by-trichomonas-vaginalis-mycoplasma-hominis-gram-negative-bacilli-and-coryneforms
#9
Alaa El-Dien M S Hosny, Waleed El-Khayat, Mona T Kashef, Mohsen N Fakhry
BACKGROUND: Preterm labor (PTL) is responsible for most cases of neonatal death. In most of these cases, the causes of PTL have not been established although several risk factors have been described. Therefore, the aim of this study was to investigate risk factors for PTL before 37 gestational weeks among Egyptian women. METHODS: In this case-control study, 117 pregnant women without risk factors for PTL were chosen. The control group (n=45) had term labor (gestational weeks≥37 weeks), and the case group (n=72) had PTL (gestational weeks < 37 weeks)...
January 13, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28092917/is-fat-mass-accretion-of-late-preterm-infants-associated-with-insulin-resistance
#10
Nadia Liotto, Maria Lorella Giannì, Francesca Taroni, Paola Roggero, Chiara Cristiana Condello, Anna Orsi, Camilla Menis, Riccardo Bonfanti, Fabio Mosca
BACKGROUND: Late preterm infants show a major fat mass accretion from birth to term. The contribution of preterm birth to the development of the metabolic syndrome is still under investigation. OBJECTIVES: To evaluate body composition changes in late preterm infants during the first 3 months and to investigate their insulin sensitivity and resistance. METHODS: We conducted an observational, longitudinal study. A total of 216 late preterm infants underwent body composition assessment using an air displacement plethysmograph at term and at 3 months of corrected age...
January 17, 2017: Neonatology
https://www.readbyqxmd.com/read/28090292/a-new-look-at-bronchopulmonary-dysplasia-postcapillary-pathophysiology-and-cardiac-dysfunction
#11
Arvind Sehgal, Andra Malikiwi, Eldho Paul, Kenneth Tan, Samuel Menahem
Pulmonary hypertension (PH) and right ventricular function are the focus of cardiovascular effects of bronchopulmonary dysplasia (BPD). We assessed cardiac indexes reflecting systemic afterload and pulmonary venous back pressure as pathophysiologic factors. Cardiac parameters were measured by conventional echocardiography in 20 preterm infants with severe BPD and compared with those of 10 preterm infants with no BPD and 20 healthy term infants. In infants with severe BPD, PH was noted in 5 (25%) by tricuspid regurgitation Doppler jet ≥2...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28087725/neurodevelopmental-outcomes-of-extremely-low-birthweight-infants-randomised-to-different-pco2-targets-the-phelbi-follow-up-study
#12
Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Annett Bläser, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Harald Bode, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler
BACKGROUND: Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial. METHODS: Infants (n=359) between 400 and 1000 g birth weight and 23 0/7-28 6/7 weeks gestational age who required endotracheal intubation and mechanical ventilation within 24 hours of birth were randomly assigned to high PCO2 or to a control group with mildly elevated PCO2 targets...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28087511/invited-commentary-ambient-environment-and-the-risk-of-preterm-birth
#13
Sandie Ha, Pauline Mendola
Preterm birth is a common adverse birth outcome known to be associated with increased infant mortality, and it often results in a higher burden of offspring morbidity in both the short and long terms. The potential for environmental factors, particularly air pollution and meteorological parameters, to increase preterm birth risk has received significant attention worldwide, but the findings are generally inconsistent, with variations in study designs and methods across populations and geographic locations. In the current issue of the Journal, Giorgis-Allemand et al...
January 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28086969/multicenter-neonatal-databases-trends-in-research-uses
#14
Liza M Creel, Sean Gregory, Catherine J McNeal, Madhava R Beeram, David R Krauss
BACKGROUND: In the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight (LBW), and 1.5% are very low birth weight (VLBW). Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28079434/previous-pregnancy-outcomes-and-subsequent-pregnancy-anxiety-in-a-quebec-prospective-cohort
#15
Gabriel D Shapiro, Jean R Séguin, Gina Muckle, Patricia Monnier, William D Fraser
INTRODUCTION: Pregnancy anxiety is an important psychosocial risk factor that may be more strongly associated with adverse birth outcomes than other measures of stress. Better understanding of the upstream predictors and causes of pregnancy anxiety could help to identify high-risk women for adverse maternal and infant outcomes. The objective of the present study was to measure the associations between five past pregnancy outcomes (live preterm birth (PTB), live term birth, miscarriage at <20 weeks, stillbirth at ≥20 weeks, and elective abortion) and pregnancy anxiety at three trimesters in a subsequent pregnancy...
January 12, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28076856/mri-differences-associated-with-intrauterine-growth-restriction-in-preterm-infants
#16
Christie J Bruno, Shreyans Bengani, William A Gomes, Mariana Brewer, Melissa Vega, Xianhong Xie, Mimi Kim, Mamta Fuloria
BACKGROUND: Preterm infants are at risk for neurodevelopmental impairment. Intrauterine growth restriction (IUGR) further increases this risk. Brain imaging studies are often utilized at or near term-equivalent age to determine later prognosis. OBJECTIVE: To evaluate the association between intrauterine growth and regional brain volume on MRI scans performed in preterm infants at or near term-equivalent age. METHODS: This is a retrospective case-control study of 24 infants born at gestational age ≤30 weeks and cared for in a large, inner-city, academic neonatal intensive-care unit from 2012 to 2013...
January 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28075545/fetal-growth-and-parental-cardiovascular-risk-preterm-birth-matters
#17
Janet M Catov
It is now well established, but poorly understood, that preterm birth marks excess cardiovascular risk among mothers. The study by Morken et al. provides new and important insights into these links by integrating preterm birth and fetal growth abnormalities as metrics of long-term parental CVD mortality risk. They report that small and large infants delivered preterm are linked to excess maternal CVD risk, but these features are only weakly associated with paternal CVD. This article is protected by copyright...
January 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28072957/-a-cross-sectional-survey-on-the-patterns-of-primary-teeth-eruption-in-2-581-children
#18
R X Li, Y Hu
Objective: To investigate the patterns of primary teeth eruption by a cross-sectional survey in 0-40 months old children in Chongqing and to provide normal timetables of tooth eruption that are practical in general physical growth assessment. Method: Data of 2 581 0-40 months old healthy children were collected from January 2014 to January 2016 at Children's Hospital of Chongqing Medical University. General information was recorded by primary child health care doctors, including age, gender, gestation age, birth weight, time and sequence of first primary tooth eruption, number of teeth and age of totally primary teeth emergence...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28068927/subgroup-identification-of-early-preterm-birth-eptb-informing-a-future-prospective-enrichment-clinical-trial-design
#19
Chuanwu Zhang, Lili Garrard, John Keighley, Susan Carlson, Byron Gajewski
BACKGROUND: Despite the widely recognized association between the severity of early preterm birth (ePTB) and its related severe diseases, little is known about the potential risk factors of ePTB and the sub-population with high risk of ePTB. Moreover, motivated by a future confirmatory clinical trial to identify whether supplementing pregnant women with docosahexaenoic acid (DHA) has a different effect on the risk subgroup population or not in terms of ePTB prevalence, this study aims to identify potential risk subgroups and risk factors for ePTB, defined as babies born less than 34 weeks of gestation...
January 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28068849/maternal-serum-calponin-1-level-as-a-biomarker-for-the-short-term-prediction-of-preterm-birth-in-women-with-threatened-preterm-labor
#20
Orkun Cetin, Erbil Karaman, Baris Boza, Numan Cim, Hanım Guler Sahin
PURPOSE: To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. MATERIALS AND METHODS: Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed-up until delivery prospectively and the perinatal outcomes of the patients were recorded...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
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