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Inhalational burn

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https://www.readbyqxmd.com/read/28530774/a-rare-type-of-burn-injury-due-to-butane-gas-inhalation
#1
Ergin Seven, Uğur Horoz, Elif Sarı, Hülda Rifat Özakpınar, Mert Muhittin Sandıkcı, Emre İnözü, Ali Teoman Tellioğlu
BACKGROUND: Abusive inhalation of butane gas is becoming a serious public health problem among teenagers and young adult population; however, there has been little reporting on explosion burns associated with abuse of butane cigarette lighter fluid. METHODS: Retrospective study was conducted of 22 patients who were burned in last 2 years in explosion of butane gas, a flammable, odorless, and colorless aliphatic hydrocarbon. RESULTS: Details of sociodemographic profile of the patients, any underlying psychiatric illness, alcohol abuse, depth of burn injury, any associated injury, duration of hospitalization, and percentage of burned area were recorded and analyzed...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28527873/comparison-of-xenon-with-led-illuminant-in-difficult-and-inhalation-injury-airway-scenario-a-randomized-crossover-manikin-study
#2
Andreas Moritz, Johannes Prottengeier, Joachim Schmidt
PURPOSE: The purpose of this study was to compare the effectiveness of a Xenon halogen with a light-emitting diode (LED) laryngoscope light handle in a difficult airway scenario, as well as in an inhalation injury airway scenario that combines a difficult airway and a limited view. METHODS: We recruited forty-two anesthetists into a randomized crossover trial. Each performed tracheal intubation (TI) with a Xenon halogen and a LED light handle in the two manikin scenarios...
May 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28496039/pyrolysis-of-ur-144-a-synthetic-cannabinoid-augments-an-affinity-to-human-cb1-receptor-and-cannabimimetic-effects-in-mice
#3
Asuka Kaizaki-Mitsumoto, Kyoko Hataoka, Masahiko Funada, Yuki Odanaka, Hiroki Kumamoto, Satoshi Numazawa
Drug abusers most often smoke 'herbal incense' as a cigarette or inhale it using a smoking tool. Smoking may cause pyrolysis of the drug and produce decomposed products of which biological effect has never been investigated. The synthetic cannabinoid UR-144 is known to undergo thermal degradation, giving a ring-opened isomer, so-called UR-144 degradant. The present study demonstrates by using UR-144 as a model drug that the smoke of burned UR-144 contains the UR-144 degradant. The UR-144 degradant showed approximately four fold higher agonist activity to human CB1 receptor and augmented hypothermic and akinetic actions in mice compared to UR-144...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28467581/can-we-make-an-early-do-not-resuscitate-decision-in-severe-burn-patients
#4
Yücel Yüce, Hakan Ahmet Acar, Kutlu Hakan Erkal, Erhan Tuncay
BACKGROUND: The present study was conducted to examine topic of issuing early do-not-resuscitate (DNR) order at first diagnosis of patients with severe burn injuries in light of current law in Turkey and the medical literature. DNR requires withholding cardiopulmonary resuscitation in event of respiratory or cardiac arrest and allowing natural death to occur. It is frequently enacted for terminal cancer patients and elderly patients with irreversible neurological disorders. METHODS: Between January 2009 and December 2014, 29 patients (3...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28452888/the-impact-of-patient-weight-on-burn-resuscitation
#5
Nehemiah T Liu, Craig A Fenrich, Maria L Serio-Melvin, Wylan C Peterson, Leopoldo C Cancio, José Salinas
INTRODUCTION: Optimal fluid resuscitation of burn patients with burns greater than 20% total body surface area (TBSA) is critical to prevent burn shock during the initial 24 to 48 hours post burn. Currently, most resuscitation formulas incorporate the patient's weight when estimating 24-hour fluid requirements. The objective of this study was to determine the impact of weight on fluid resuscitation requirements and outcomes during the initial 24 hours after admission. METHODS: We performed a retrospective review of patients admitted to our burn intensive care unit from December 2007 to April 2013, resuscitated with a computerized decision support system...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28452873/platelet-and-coagulation-function-before-and-after-burn-and-smoke-inhalation-injury-in-sheep
#6
Nicolas J Prat, Maryanne C Herzig, Stefan Kreyer, Robbie K Montgomery, Bijaya K Parida, Katharina Linden, Vittorio Scaravilli, Slava M Belenkiy, Leopoldo C Cancio, Andriy I Batchinsky, Andrew P Cap
BACKGROUND: Smoke inhalation and burn injury remain a major source of morbidity and mortality. There is known dysregulation of hemostasis in burn patients, but either hyper- or hypocoagulation states are reported. Sheep are an established animal model for studying burn pathology and provide robust data on hemostatic function at baseline and after injury. METHODS: Following an IACUC-approved protocol, 15 sheep were anesthetized and subjected to a 40% full thickness burn with smoke inhalation...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28443378/toxicity-resulting-from-exposure-to-oven-cleaners-as-reported-to-the-uk-national-poisons-information-service-npis-from-2009-to-2015
#7
Rachael C Day, Sally M Bradberry, Euan A Sandilands, Simon H L Thomas, John P Thompson, J Allister Vale
INTRODUCTION: Oven cleaning products contain corrosive substances, typically sodium or potassium hydroxide. OBJECTIVE: To determine the reported toxicity from exposure to oven cleaning products. METHODS: Telephone enquiries to the UK National Poisons Information Service regarding oven cleaning products were analysed retrospectively for the period January 2009 to December 2015. RESULTS: There were 796 enquiries relating to 780 patients...
April 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28438352/burns-to-the-genitalia-perineum-and-buttocks-increase-the-risk-of-death-among-u-s-service-members-sustaining-combat-related-burns-in-iraq-and-afghanistan
#8
Michael S Clemens, Judson C Janak, Julie A Rizzo, John C Graybill, Michelle F Buehner, Steven J Hudak, Charles K Thompson, Kevin K Chung
PURPOSE: Among service members injured in Iraq and Afghanistan, to determine the risk of mortality associated with combat-related burns to the genitalia, perineum, and buttocks. MATERIALS AND METHODS: The prospectively maintained burn registry from the United States Army Institute of Surgical Research was retrospectively reviewed to identify all service members with combat-related burns sustained in Iraq and Afghanistan from March 2003 to October 2013. The two primary risk factors of interest were (1) any burn to the genitals, perineum, and/or buttocks (PB) and (2) burns involving the entire perineal, genital, and buttock region (complete PB)...
April 21, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28434250/rolling-tobacco-in-banana-leaves-newspaper-or-copybook-paper-associated-with-significant-reduction-in-lung-function-in-vanuatu
#9
Charles A Weitz, Kathryn M Olszowy, Kelsey N Dancause, Cheng Sun, Alysa Pomer, Howard Silverman, G Lee, Len Tarivonda, Chim W Chan, Akira Kaneko, J K Lum, Ralph M Garruto
In addition to the widespread availability of packaged cigarettes, the inhabitants of island nations of the Southwest Pacific frequently smoke commercially available loose tobacco using manufactured rolling papers, as well as locally grown tobacco rolled in manufactured rolling paper or wrapped in leaves, copybook paper, and newspaper. In this study, Vanuatu men who smoked local tobacco rolled in leaves, copybook paper, or newspaper showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC ratios than men who smoked packaged cigarettes, store-bought tobacco rolled in manufactured rolling paper, or who smoked locally grown tobacco rolled in manufactured rolling papers...
April 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28431417/the-occurrence-of-single-and-multiple-organ-dysfunction-in-pediatric-electrical-versus-other-thermal-burns
#10
Gabriel Hundeshagen, Paul Wurzer, Abigail A Forbes, Charles D Voigt, Vanessa N Collins, Janos Cambiaso-Daniel, Celeste C Finnerty, David N Herndon, Ludwik K Branski
BACKGROUND: Multiple organ failure (MOF) is a major contributor to morbidity and mortality in burned children. While various complications induced by electrical injuries have been described, the incidence and severity of single organ failure (SOF) and MOF associated with this type of injury are unknown. The study was undertaken to compare the incidence and severity of SOF and MOF as well as other complications between electrically and thermally burned children. PATIENTS AND METHODS: Between 2001 and 2016, 288 pediatric patients with electrical burns (EB; n = 96) or thermal burns (CTR; n = 192) were analyzed in this study...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28423388/a-national-study-of-the-effect-of-race-socioeconomic-status-and-gender-on-burn-outcomes
#11
Hala Bedri, Kathleen S Romanowski, Junlin Liao, Ghassan Al-Ramahi, Jason Heard, Thomas Granchi, Lucy Wibbenmeyer
Age, burn size, and inhalation injury are the major contributing variables related to burn mortality. While the female gender has been linked to higher mortality, the impact of socioeconomic status has not been well studied. The interplay between these three factors is also unknown. This study sought to clarify the effects of these variables on outcomes in a national sample of patients with burns. A retrospective review of 172,640 patient records of the National Burn Repository (version 8, 2002-2011) data was conducted...
May 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28419893/carbon-monoxide-related-fatalities-a-60-year-single-institution-experience
#12
Martin Janík, Michaela Ublová, Štepánka Kučerová, Petr Hejna
OBJECTIVE: Though carbon monoxide (CO) poisonings account currently for a relatively small percentage of total non-natural deaths in Europe, they represent a serious public health burden and significant component of avoidable mortality in many countries. Our aim was to investigate long-term trends and to determine epidemiologic characteristics of the CO-related deaths in the Czech Republic, recorded at the Department of Forensic Medicine in Hradec Králové. METHODS: This was an autopsy-based single-centre retrospective cohort study of all fatalities caused by CO poisoning over six decades (1947-2006)...
April 13, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28412132/pre-existing-psychiatric-disorder-in-the-burn-patient-is-associated-with-worse-outcomes
#13
Alexandra Hudson, Sarah Al Youha, Osama A Samargandi, Justin Paletz
OBJECTIVE: To compare patient and burn characteristics between patients who had a pre-existing psychiatric diagnosis and patients who did not in a Burn Unit at an academic hospital. BACKGROUND: Psychosocial issues are common in patients recovering from a burn; however, little is known regarding hospital course and discharge outcomes in patients with a pre-existing psychiatric diagnosis presenting with a burn. Baseline medical comorbidities of burn patients have been shown to be a significant risk for in-hospital mortality...
April 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28410931/a-model-of-recovery-from-inhalation-injury-and-cutaneous-burn-in-ambulatory-swine
#14
David M Burmeister, Matthew K McIntyre, Brendan Beely, Bryan Jordan, Kerfoot P Walker, James K Aden, Andriy Batchinsky, Kevin K Chung, Leopoldo C Cancio, Robert J Christy
Inhalation injury commonly accompanies thermal injury, increasing the likelihood of mortality and multiple organ dysfunction (MOD). Large animal models have given important insight into the pathophysiology of this injury; however recapitulating late MOD has remained difficult. The current report describes experiments using a smoke inhalation and burn model, with follow-up of ambulatory swine for 14days with bronchoscopy, CT scanning, and bronchoalveolar lavage fluid (BALF)/blood collection. Clinically, animals cleared airway damage in the first several days after-injury...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28395264/polycyclic-aromatic-hydrocarbons-and-their-derivatives-nitro-pahs-oxygenated-pahs-and-azaarenes-in-pm2-5-from-southern-european-cities
#15
Célia A Alves, Ana M Vicente, Danilo Custódio, Mário Cerqueira, Teresa Nunes, Casimiro Pio, Franco Lucarelli, Giulia Calzolai, Silvia Nava, Evangelia Diapouli, Konstantinos Eleftheriadis, Xavier Querol, Benjamin A Musa Bandowe
Atmospheric particulate matter (PM2.5) samples were collected over two one month periods during winter and summer in three Southern European cities (Oporto - traffic site, Florence - urban background, Athens - suburban). Concentrations of 27 polycyclic aromatic hydrocarbons (PAHs), 15 nitro-PAHs (NPAHs), 15 oxygenated-PAHs (OPAHs) and 4 azaarenes (AZAs) were determined. On average, the winter-summer concentrations of ΣPAHs were 16.3-5.60, 7.75-3.02 and 3.44-0.658ngm(-3) in Oporto, Florence and Athens, respectively...
October 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28387072/-e-cigarette-and-smoking-cessation-current-situation-in-belgium
#16
REVIEW
P Bartsch, M Delvaux, E Englebert, M H Beaupain, R Louis
Because of the devastating health effect of chronic burned tobacco inhalation, smoking cessation is a public health priority. After a short review of the validated pharmacological tools for smoking cessation we have analysed the clinical data obtained with the increasingly popular e-cigarette as an aid to help current smokers to quit. Although e-cigarette has not proved its effectiveness in smoking cessation yet, the public health authorities have usually adopted a pragmatic position. They recommend trying e-cigarette when validated pharmacological tools have failed in making patients abstinent, on the basis that e-cigarette is strongly assumed to be less toxic and may still help reducing the amount of smoked cigarettes...
January 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28385809/free-actin-impairs-macrophage-bacterial-defenses-via-scavenger-receptor-marco-interaction-with-reversal-by-plasma-gelsolin
#17
Christine M Ordija, Terry Ting-Yu Chiou, Zhiping Yang, Glen M Deloid, Melina de Oliveira Valdo, Zhi Wang, Alice Bedugnis, Terry L Noah, Samuel Jones, Henry Koziel, Lester Kobzik
Lung injury can release intracellular actin into the alveolar milieu, and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated free actin release into the lung lavage fluids of mouse models of ozone injury, influenza infection and secondary pneumococcal pneumonia, and in samples from patients following burn and inhalation injury. Using levels comparable to those observed in lung injury, we found that free actin markedly inhibited murine lung macrophage binding and uptake in vitro of S...
April 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28368919/a-national-perspective-on-ecmo-utilization-in-patients-with-burn-injury
#18
Lauren B Nosanov, Melissa M McLawhorn, Mariana Vigiola Cruz, Jason H Chen, Jeffrey W Shupp
Extracorporeal membranous oxygenation (ECMO) has become an increasingly utilized strategy to support patients in cardiac and cardiopulmonary failure. The Extracorporeal Life Support Organization reports adult survival rates between 40 and 50%. Utilization and outcomes for burned patients undergoing ECMO are poorly understood. The National Burn Repository (version 8.0) was queried for patients with ICD9 procedure codes for ECMO. Demographics, comorbidities, mechanism, injury details, and clinical outcomes were recorded...
March 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28360004/outdoor-and-indoor-particle-characterization-from-a-large-and-uncontrolled-combustion-of-a-tire-landfill
#19
B Artíñano, F J Gómez-Moreno, E Díaz, F Amato, M Pandolfi, E Alonso-Blanco, E Coz, S García-Alonso, M Becerril-Valle, X Querol, A Alastuey, B L van Drooge
A large and uncontrolled fire of a tire landfill started in Seseña (Toledo, Spain) on May 13, 2016. An experimental deployment was immediately launched in the area for measuring regulated and non-standard air quality parameters to assess the potential impact of the plume at local and regional levels. Outdoor and indoor measurements of different parameters were carried out at a near school, approximately 700m downwind the burning tires. Real time measurements of ambient black carbon (BC) and total number particle concentrations were identified as good tracers of the smoke plume...
March 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28358811/alterations-in-airway-microbiota-in-patients-with-pao2-fio2-ratio-%C3%A2-300-after-burn-and-inhalation-injury
#20
Dana M Walsh, Shaun D McCullough, Scott Yourstone, Samuel W Jones, Bruce A Cairns, Corbin D Jones, Ilona Jaspers, David Diaz-Sanchez
BACKGROUND: Injury to the airways after smoke inhalation is a major mortality risk factor in victims of burn injuries, resulting in a 15-45% increase in patient deaths. Damage to the airways by smoke may induce acute respiratory distress syndrome (ARDS), which is partly characterized by hypoxemia in the airways. While ARDS has been associated with bacterial infection, the impact of hypoxemia on airway microbiota is unknown. Our objective was to identify differences in microbiota within the airways of burn patients who develop hypoxemia early after inhalation injury and those that do not using next-generation sequencing of bacterial 16S rRNA genes...
2017: PloS One
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