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Inhalational burn

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https://www.readbyqxmd.com/read/29029861/burn-injury-outcomes-in-patients-with-pre-existing-diabetic-mellitus-risk-of-hospital-acquired-infections-and-inpatient-mortality
#1
Laquanda Knowlin, Paula D Strassle, Felicia N Williams, Richard Thompson, Samuel Jones, David J Weber, David van Duin, Bruce A Cairns, Anthony Charles
BACKGROUND: Diabetes mellitus (DM) is a major cause of illness and death in the United States, and diabetic patients are at increased risk for burn injury. We therefore sought to examine the impact of pre-existing DM on the risk of inpatient mortality and hospital acquired infections (HAI) among burn patients. METHODS: Adult patients (≥18 years old) admitted from 2004 to 2013 were analyzed. Weighted Kaplan-Meier survival curves - adjusting for patient demographics, burn mechanism, presence of inhalation injury, total body surface area, additional comorbidities, and differential lengths of stay - were used to estimate the 30-day and 60-day risk of mortality and HAIs...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29023362/glycocalyx-shedding-is-enhanced-by-age-and-correlates-with-increased-fluid-requirement-in-patients-with-major-burns
#2
Akinori Osuka, Hirofumi Kusuki, Kazuhiro Yoneda, Hiroshi Matsuura, Hisatake Matsumoto, Hiroshi Ogura, Masashi Ueyama
BACKGROUND: Massive fluid shift following severe burn injury leads to edema and intravascular fluid loss that may result in burn-induced compartment syndrome (BICS) when corrected by aggressive fluid resuscitation. Factors causing this fluid shift remain unclear. Because glycocalyx regulates endothelial permeability, we hypothesized that glycocalyx shedding would increase fluid requirements in burn patients. This prospective cohort study aimed to identify relationships between shedding of the glycocalyx and fluid requirements following burn injury...
October 11, 2017: Shock
https://www.readbyqxmd.com/read/29021726/investigating-the-relationship-between-microalbuminuria-and-prognosis-of-patients-with-severe-burns-in-the-motahari-burn-hospital
#3
M Roham, K Anbari, M J Fatemi, M Momeni
Microalbuminuria seems to be a reflection of increased vascular permeability caused by systemic inflammatory response, and is likely to be a predictor of mortality, sepsis and other outcomes of severe burn patients. We investigated the impact of microalbuminuria on the prognosis of patients with severe burns. This is a prospective study on severe burn patients (above 20%) admitted in the first 24 hours after burns to the Motahari Burn Hospital. Patients' microalbuminuria was measured at admission and 48 hours later, and its relationship with patient prognosis (sepsis, renal failure, death, inhalation injury and systemic inflammatory response syndrome) was analyzed...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29021724/inhalation-injury-in-a-burn-unit-a-retrospective-review-of-prognostic-factors
#4
D Monteiro, I Silva, P Egipto, A Magalhães, R Filipe, A Silva, A Rodrigues, J Costa
Inhalation injury (InI) is known to seriously affect the prognosis of burn patients, as it is strongly associated with high morbidity and mortality. Despite major advances in the treatment of burn patients in the past years, advances in the treatment of smoke InI have been somewhat limited; mortality reduction mostly results from improvements in critical care. It is difficult to separate the contribution of InI from other mechanisms that also affect respiratory tract and lungs. The aim of this study was to compare patients with and without InI and to identify prognostic factors among patients with smoke InI...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29020019/they-re-heating-up-internet-search-query-trends-reveal-significant-public-interest-in-heat-not-burn-tobacco-products
#5
Theodore L Caputi, Eric Leas, Mark Dredze, Joanna E Cohen, John W Ayers
Heat-not-burn tobacco products, battery powered devices that heat leaf tobacco to approximately 500 degrees Fahrenheit to produce an inhalable aerosol, are being introduced in markets around the world. Japan, where manufacturers have marketed several heat-not-burn brands since 2014, has been the focal national test market, with the intention of developing global marketing strategies. We used Google search query data to estimate, for the first time, the scale and growth potential of heat-not-burn tobacco products...
2017: PloS One
https://www.readbyqxmd.com/read/28982177/adipose-derived-stem-cells-attenuate-pulmonary-microvascular-hyperpermeability-after-smoke-inhalation
#6
Koji Ihara, Satoshi Fukuda, Baigalmaa Enkhtaivan, Raul Trujillo, Dannelys Perez-Bello, Christina Nelson, Anita Randolph, Suzan Alharbi, Hira Hanif, David Herndon, Donald Prough, Perenlei Enkhbaatar
BACKGROUND: Pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS). Smoke inhalation causes ARDS, thus significantly increasing the mortality of burn patients. Adipose-derived stem cells (ASCs) exert potent anti-inflammatory properties. The goal of the present study was to test the safety and ecfficacy of ASCs, in a well-characterized clinically relevant ovine model of ARDS. METHODS: Female sheep were surgically prepared. ARDS was induced by cooled cotton smoke inhalation...
2017: PloS One
https://www.readbyqxmd.com/read/28969436/acquired-methemoglobinemia-after-hydroxocobalamin-administration-in-a-patient-with-burns-and-inhalation-injury
#7
Alisha Z Jiwani, Vikhyat S Bebarta, Leopoldo C Cancio
CONTEXT: Hydroxocobalamin is an effective cyanide antidote. While erythema, hypertension, and chromaturia are recognized side effects, methemoglobinemia has not been reported. Methemoglobin levels are most accurately measured by co-oximetry. We describe an extensively burned patient who developed methemoglobinemia within an hour of hydroxocobalamin administration. CASE DETAILS: A 47-year old man without genetic deficiencies or abnormal hemoglobin variants presented with 61% body surface area thermal burns and grade 1 inhalation injury sustained during a tugboat engine explosion...
October 3, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28963867/management-of-head-and-neck-burns-a-15-year-review
#8
Travis J Hamilton, Jeromy Patterson, Rachael Y Williams, Walter L Ingram, Juvonda S Hodge, Shelly Abramowicz
PURPOSE: The purpose of this project was to characterize patients with isolated head and neck burns admitted to the Grady Memorial Hospital (GMH) Burn Center (Atlanta, GA). MATERIALS AND METHODS: This was a retrospective case series of patients admitted to the GMH Burn Center with the primary diagnosis of head and neck burns from 2000 through 2015. Demographic data (gender and age) were recorded. Burn details (etiology, mechanism, percentage of burned total body surface area, depth, and associated injuries) were summarized...
September 11, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28962529/editor-s-highlight-pulmonary-vascular-thrombosis-in-rats-exposed-to-inhaled-sulfur-mustard
#9
Matthew D McGraw, Christopher M Osborne, Emily J Mastej, Jorge A Di Paola, Dana R Anderson, Wesley W Holmes, Danielle C Paradiso, Rhonda B Garlick, Tara B Hendry-Hofer, Raymond C Rancourt, Russell W Smith, Carol Burns, Gates B Roe, Jacqueline S Rioux, Carl W White, Livia A Veress
Sulfur mustard (SM) is a chemical warfare agent. When inhaled, SM causes significant injury to the respiratory tract. Although the mechanism involved in acute airway injury after SM inhalation has been well described previously, the mechanism of SM's contribution to distal lung vascular injury is not well understood. We hypothesized that acute inhalation of vaporized SM causes activated systemic coagulation with subsequent pulmonary vascular thrombi formation after SM inhalation exposure. Sprague Dawley rats inhaled SM ethanolic vapor (3...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28959633/aerosol-characterization-and-pulmonary-responses-in-rats-after-short-term-inhalation-of-fumes-generated-during-resistance-spot-welding-of-galvanized-steel
#10
James M Antonini, Aliakbar Afshari, Terence G Meighan, Walter McKinney, Mark Jackson, Diane Schwegler-Berry, Dru A Burns, Ryan F LeBouf, Bean T Chen, Mohammad Shoeb, Patti C Zeidler-Erdely
Resistance spot welding is a common process to join metals in the automotive industry. Adhesives are often used as sealers to seams of metals that are joined. Anti-spatter compounds sometimes are sprayed onto metals to be welded to improve the weldability. Spot welding produces complex aerosols composed of metal and volatile compounds (VOCs) which can cause lung disease in workers. Male Sprague-Dawley rats (n = 12/treatment group) were exposed by inhalation to 25 mg/m(3) of aerosol for 4 h/day × 8 days during spot welding of galvanized zinc (Zn)-coated steel in the presence or absence of a glue or anti-spatter spray...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28953914/does-inhalation-injury-predict-mortality-in-burns-patients-or-require-redefinition
#11
Youngmin Kim, Dohern Kym, Jun Hur, Jaechul Yoon, Haejun Yim, Yong Suk Cho, Wook Chun
Inhalation injury is known to be an important factor in predicting mortality in burns patients. However, the diagnosis is complicated by the heterogeneous presentation and inability to determine the severity of inhalation injury. The purpose of this study was to identify clinical features of inhalation injury that affect mortality and the values that could predict the outcome more precisely in burns patients with inhalation injury. This retrospective observational study included 676 burns patients who were over 18 years of age and hospitalized in the Burns Intensive Care Unit between January 2012 and December 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28944866/early-anticoagulation-therapy-for-severe-burns-complicated-by-inhalation-injury-in-a-rabbit-model
#12
Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
The aim of the present study was to determine the effects of early anticoagulation treatment on severe burns complicated by inhalation injury in a rabbit model. Under anesthetization, an electrical burns instrument (100˚C) was used to scald the backs of rabbits for 15 sec, which established a 30% III severe burns model. Treatment of the rabbits with early anticoagulation effectively improved the severe burns complicated by inhalation injury‑induced lung injury, reduced PaO2, PaCO2 and SPO2 levels, suppressed the expression of tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, and increased the activity of IL‑10...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944226/a-prospective-analysis-of-risk-factors-for-pediatric-burn-mortality-at-a-tertiary-burn-center-in-north-india
#13
Amol Dhopte, Rahul Bamal, Vinay Kumar Tiwari
BACKGROUND: None of the available mortality predicting models in pediatric burns precisely predicts outcomes in every population. Mortality rates as well as their risk factors vary with regions and among different centers within the regions. The aim of this study was to identify socio-demographic and clinical risk factors for mortality in pediatric burns in an effort to decrease the mortality in these patients. METHODS: A prospective analytical study was conducted in patients up to the age of 18 years admitted for burn injuries in a tertiary care burn center in India from January to December 2014...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28933559/-parallel-investigations-of-blood-and-alveolar-air-in-the-diagnosis-of-lethal-carbon-monoxide-poisoning
#14
Miroslav Bauer, Jiřina Bauerová, Peter Očko, Jozef Šidlo
Carbon monoxide poisonings are the most frequent among fatal gas and volatile substances intoxications. The authors present diagnostic options of fatal carbon monoxide poisoning by parallel blood investigations for the content of karbonylhaemoglobin and determining of the concentration of carbon monoxide in the alveolar air. The analysis of 160 cases of lethal poisonings with carbon monoxide over a period of 20 years was carried out. The cases were divided into subgroups according to the place of death to poisonings in flats, garages, bathrooms, in fires, road traffic accidents and mining accidents...
2017: Soudní Lékarství
https://www.readbyqxmd.com/read/28926874/-multicenter-epidemiological-investigation-of-hospitalized-elderly-young-and-middle-aged-patients-with-severe-burn
#15
Y Tang, L X Wang, W G Xie, Z A Shen, G H Guo, J J Chen, C M Han, L C Ren, Z G Chu, M F Yin, Y Wang, D X Zhang, Y S Huang, J P Zhang
Objective: To compare and analyze the epidemiological characteristics of hospitalized elderly, young and middle-aged patients with severe burn in recent years, so as to provide reference for the prevention and treatment of elderly patients with severe burn. Methods: Relying on the entry system of epidemiological case data and biological sample of severe burn from multicenter in clinic, medical records of patients with severe burn, aged above 18, hospitalized in 8 burn wards from January 2012 to December 2015 were collected...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28925655/pleuritic-chest-pain-sorting-through-the-differential-diagnosis
#16
Brian V Reamy, Pamela M Williams, Michael Ryan Odom
Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling. Pulmonary embolism is the most common serious cause, found in 5% to 21% of patients who present to an emergency department with pleuritic chest pain. A validated clinical decision rule for pulmonary embolism should be employed to guide the use of additional tests such as d-dimer assays, ventilation-perfusion scans, or computed tomography angiography. Myocardial infarction, pericarditis, aortic dissection, pneumonia, and pneumothorax are other serious causes that should be ruled out using history and physical examination, electrocardiography, troponin assays, and chest radiography before another diagnosis is made...
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28900039/the-contributing-risk-of-tobacco-use-for-ards-development-in-burn-injured-adults-with-inhalation-injury
#17
Majid Afshar, Giora Netzer, Michael J Mosier, Richard S Cooper, William Adams, Ellen L Burnham, Elizabeth J Kovacs, Ramon Durazo-Arvizu, Stephanie Kliethermes
BACKGROUND: This study aims to determine the relationship between tobacco use, inhalation injury, and ARDS in burn-injured adults. METHODS: This study was an observational cohort of 2,485 primary burn admissions to a referral burn center between January 1, 2008 and March 15, 2015. Subjects were evaluated by methods used to account for mediation and traditional approaches (multivariable logistic regression and propensity score analysis). Mediation analysis examined both the (1) indirect effect of tobacco use via inhalation injury as the mediator on ARDS development and (2) the direct effect of tobacco use alone on ARDS development...
September 12, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28883446/biomass-burning-in-the-amazon-region-causes-dna-damage-and-cell-death-in-human-lung-cells
#18
Nilmara de Oliveira Alves, Alexandre Teixeira Vessoni, Annabel Quinet, Rodrigo Soares Fortunato, Gustavo Satoru Kajitani, Milena Simões Peixoto, Sandra de Souza Hacon, Paulo Artaxo, Paulo Saldiva, Carlos Frederico Martins Menck, Silvia Regina Batistuzzo de Medeiros
Most of the studies on air pollution focus on emissions from fossil fuel burning in urban centers. However, approximately half of the world's population is exposed to air pollution caused by biomass burning emissions. In the Brazilian Amazon population, over 10 million people are directly exposed to high levels of pollutants resulting from deforestation and agricultural fires. This work is the first study to present an integrated view of the effects of inhalable particles present in emissions of biomass burning...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877134/the-use-of-intravenous-and-inhaled-colistin-therapy-during-a-burn-center-outbreak-of-multidrug-resistant-acinetobacter-baumannii
#19
Tomas J Saun, Alan D Rogers, Jerome A Leis, Robert Cartotto
The authors report on the use of combination intravenous and inhaled colistin therapy in 2 patients with major burns admitted to an American Burn Association-verified burn center during a multidrug-resistant (MDR) Acinetobacter baumannii outbreak. Both patients had documented, culture-proven MDR Acinetobacter ventilator-associated pneumonia and bacteremia leading to sepsis. Both patients were successfully extubated and subsequently discharged from hospital. In this article, the authors provide the timeline of events and treatments that were used in these 2 cases...
August 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28876693/continuation-of-feeds-in-the-unstable-burns-patient
#20
A L Rooi, A Muganza, E A Ndobe, M Nel
BACKGROUND: Early enteral nutrition (EEN) and the continuation of enteral nutrition (EN) are critical factors in burn patients, who typically have higher nutritional needs due to their post-injury hypercatabolic state and their additional need for nutrients to aid in the healing of wounds and skin grafts. In the critically ill patient, EN is the preferred mode of administration; however, controversy exists regarding the concomitant use of EN and intravenous vasopressor agents in the haemodynamically unstable patient...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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