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Brain tumor surgery

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https://www.readbyqxmd.com/read/29218405/multimodal-treatments-combined-with-gamma-knife-surgery-for-primary-atypical-teratoid-rhabdoid-tumor-of-the-central-nervous-system-a-single-institute-experience-of-18-patients
#1
Yan-Ming Ren, Xia Wu, Chao You, Yue-Kang Zhang, Qiang Li, Yan Ju
OBJECTIVES: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare, highly malignant tumor of the central nervous system with poor prognosis. Nowadays, multimodal management, including surgery, chemotherapy (CMT), and radiation therapy (RT), is advocated. However, AT/RT treatment with gamma knife surgery (GKS) was rarely reported. The aim of this study was to assess the efficacy and safety of GKS for the treatment of AT/RT. PATIENTS AND METHODS: Medical records of AT/RT patients who underwent surgery from 2007 to 2014 at the West China Hospital were retrospectively reviewed and statistically analyzed...
December 7, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29216530/brain-angiometastasis-from-a-non-seminomatous-germ-cell-tumor-a-case-report
#2
Alejandro Monroy-Sosa, Gervith Reyes-Soto, Bernardo Cacho-Díaz, Martín Granados-García, Allan Hernández Estrada, Ana María Cano-Valdez, Ángel Herrera-Gómez
INTRODUCTION: Brain metastasis from non-seminomatous germ cell tumors (NSGCT) is rare. Herein, we describe the second reported case of brain metastasis from a NSGCT with high-flow arteriovenous (AV) shunts, and propose a novel surgical treatment plan. CLINICAL CASE: The patient was a 34-year-old male who presented with hemiparesis and hemianesthesia. Magnetic resonance angiography revealed three vascular lesions with afferent vessels and efferent vessels. Angiography displayed two high-flow AV shunts...
December 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29209586/diffusion-tensor-imaging-and-tractography-application-in-pre-operative-planning-of-intra-axial-brain-lesions
#3
Neetu Soni, Anant Mehrotra, Sanjay Behari, Sunil Kumar, Nishant Gupta
Gliomas are the most common brain tumors that diffusely infiltrate the surrounding white matter (WM) tracts. Conventional MRI is commonly used for tumor localization and characterization. However, this does not give precise information about the WM infiltration surrounding the tumor. Diffusion-tensor imaging (DTI) is a non-invasive magnetic resonance (MR) technique that measures WM tissue integrity and tractography (fiber tracking) used to investigate the preferential directionality of diffusion. DTI allows visualization of WM tracts in the immediate vicinity of brain tumors that permit maximum tumor resection while also preserving the eloquent brain areas...
October 3, 2017: Curēus
https://www.readbyqxmd.com/read/29204523/fractionated-stereotactic-radiation-therapy-for-intact-brain-metastases
#4
Samuel R Marcrom, Andrew M McDonald, Jonathan W Thompson, Richard A Popple, Kristen O Riley, James M Markert, Christopher D Willey, Markus Bredel, John B Fiveash
Purpose: Limited data exist on fractionated stereotactic radiation therapy (FSRT) for brain metastases. We sought to evaluate the safety and efficacy of FSRT and further define its role in brain metastasis management. Methods and materials: A total of 72 patients were treated with linear accelerator-based FSRT to 182 previously untreated, intact brain metastases. Targets received 25 or 30 Gy in 5 fractions. All targets within the same course received the same prescription regardless of size...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204309/laser-application-in-neurosurgery
#5
REVIEW
Evgenii Belykh, Kaan Yagmurlu, Nikolay L Martirosyan, Ting Lei, Mohammadhassan Izadyyazdanabadi, Kashif M Malik, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
Background: Technological innovations based on light amplification created by stimulated emission of radiation (LASER) have been used extensively in the field of neurosurgery. Methods: We reviewed the medical literature to identify current laser-based technological applications for surgical, diagnostic, and therapeutic uses in neurosurgery. Results: Surgical applications of laser technology reported in the literature include percutaneous laser ablation of brain tissue, the use of surgical lasers in open and endoscopic cranial surgeries, laser-assisted microanastomosis, and photodynamic therapy for brain tumors...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29204199/clinicopathological-study-of-pediatric-posterior-fossa-tumors
#6
Kadali Satya Vara Prasad, D Ravi, Vijay Pallikonda, Bhavana Venkata Satya Raman
Context: Brain tumor is one of the most devastating forms of human illness, especially when occurring in the posterior fossa and involving the brainstem. Tumors in the posterior fossa are considered some of the most critical brain lesions. This is primarily due to the limited space within the posterior fossa, as well as the potential involvement of the vital brainstem nuclei. Aims: The aim of this study is to analyze the incidence, clinical features, surgical outcome, complications, and prognosis in a series of 37 pediatric patients with posterior fossa tumors who underwent surgery between September 2012 and January 2015 from the Department of Neurosurgery, King George Hospital, Visakhapatnam (both prospective and retrospective study)...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29204198/profile-and-outcome-of-pediatric-brain-tumors-experience-from-a-tertiary-care-pediatric-oncology-unit-in-south-india
#7
Supriya Gujjar Suresh, Arathi Srinivasan, Julius Xavier Scott, Santosh Mohan Rao, Balasubramaniam Chidambaram, Sanjay Chandrasekar
Context: Tumors of the central nervous system (CNS) constitute the second most common pediatric cancers. Unlike leukemia, management of CNS tumors requires a good multidisciplinary team. Higher rates of treatment abandonment are documented in view of complexity of the treatment with long duration, involving neurosurgery, radiation, chemotherapy, and high cost of treatment. Morbidity associated with CNS tumors may be significant in terms of physical deficits as well as neuropsychological and neuroendocrine sequelae...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29204195/magnitude-of-neurogenic-tumor-burden-in-pediatric-population-a-tertiary-care-center-study
#8
Shagufta Qadri, Mahboob Hasan, Kafil Akhtar
Objective: Progress in the diagnosis and treatment of childhood neoplasm in the past few decades is one of the most gratifying achievements in the field of oncology. This study was aimed to ascertain the burden (incidence and prevalence) and histopathologic features of neurogenic tumors occurring in the pediatric population. Materials and Methods: The study evaluated a total of 492 cases of pediatric tumors over a period of 8 years from 2007 to 2015, including patients of 0-12 years of age group; attending the out-patients and in-patients Department of Pediatrics and Pediatric Surgery at Jawaharlal Nehru Medical College, AMU, Aligarh, with the complaints of tumor or tumor associated sign and symptoms...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29200677/evaluation-of-intraoperative-cytological-smears-for-diagnosis-of-brain-tumors-with-special-reference-to-immunohistochemistry
#9
Saurav Sarkar, Moumita Sengupta, Chhanda Datta, Uttara Chatterjee, Samarendra Nath Ghosh
Context: Brain tumors are heterogeneous group of benign and malignant tumors of glial, meningeal, neuronal, embryonal, and lymphoid origin. Rapid intraoperative diagnosis of the nature of the tumor helps the surgeon to plan the extent of surgery and modify it accordingly. Aims: (1) To establish the validity and reliability of squash cytology in the intraoperative diagnosis of brain tumors. (2) To correlate with histopathological report and immunohistochemistry (IHC) profile...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29200156/sustained-response-to-targeted-therapy-in-a-patient-with-disseminated-anaplastic-pleomorphic-xanthoastrocytoma
#10
Nisreen Amayiri, Maisa Swaidan, Maysa Al-Hussaini, Hadeel Halalsheh, Anwar Al-Nassan, Awni Musharbash, Uri Tabori, Cynthia Hawkins, Eric Bouffet
Pleomorphic xanthoastrocytoma is a rare brain tumor with unique high frequency of BRAF V600E mutation which is plausible for targeted therapy. The anaplastic variant has generally worse prognosis. We present an adolescent patient with a disseminated relapse of anaplastic pleomorphic xanthoastrocytoma following surgery, radiotherapy, and chemotherapy. She had a dramatic and prolonged response to a BRAF inhibitor (Dabrafinib) and later to addition of a MEK inhibitor (Trametinib) on tumor progression. With minimal side effects and a good quality of life, the patient is alive more than 2 years after initiation of targeted therapy...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29200117/common-histologically-benign-tumors-of-the-brain
#11
Roy E Strowd, Jaishri O Blakeley
PURPOSE OF REVIEW: As a group, benign tumors account for the majority of primary neoplasms affecting the central nervous system (CNS). This article reviews the epidemiology, clinical presentation, neuroimaging features, and management of the most common of these tumors: meningiomas, schwannomas, and pituitary adenomas. RECENT FINDINGS: Awareness of the most common nonmalignant tumors of the CNS and their management guidelines is important as many of these tumors are managed conservatively, with neurologists playing a primary role in both surveillance and symptom management...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29200111/low-grade-gliomas
#12
David Schiff
PURPOSE OF REVIEW: Low-grade gliomas present vexing management issues for neuro-oncologists. The relatively long survival compared to other brain tumors makes consideration of treatment toxicity, and thus timing of potentially damaging interventions such as surgery, radiation, and chemotherapy, crucial. Moreover, the rarity of these tumors makes clinical trials to ascertain optimal care challenging. RECENT FINDINGS: The discovery that most low-grade gliomas harbor isocitrate dehydrogenase (IDH) mutations that confer a favorable prognosis has improved diagnosis and risk stratification of these tumors...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29197227/involvement-of-the-middle-frontal-gyrus-in-language-switching-as-revealed-by-electrical-stimulation-mapping-and-functional-magnetic-resonance-imaging-in-bilingual-brain-tumor-patients
#13
Joanna Sierpowska, Alejandro Fernandez-Coello, Alba Gomez-Andres, Àngels Camins, Sara Castañer, Montserrat Juncadella, Andreu Gabarrós, Antoni Rodríguez-Fornells
Neural basis of language switching and the cognitive models of bilingualism remain controversial. We explored the functional neuroanatomy of language switching implementing a new multimodal protocol assessing neuropsychological, functional magnetic resonance and intraoperative electrical stimulation mapping results. A prospective series of 9 Spanish-Catalan bilingual candidates for awake brain surgery underwent a specific language switching paradigm implemented both before and after surgery, throughout the electrical stimulation procedure and during functional magnetic resonance both pre- and postoperatively...
November 14, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29194500/eano-guidelines-for-the-diagnosis-and-treatment-of-ependymal-tumors
#14
Roberta Rudà, Guido Reifenberger, Didier Frappaz, Stefan M Pfister, Anne Laprie, Thomas Santarius, Patrick Roth, Joerg Christian Tonn, Riccardo Soffietti, Michael Weller, Elizabeth Cohen-Jonathan Moyal
Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus, the level of evidence of diagnostic and therapeutic interventions is higher in the pediatric compared with the adult patient population.The diagnosis and disease staging is performed by craniospinal MRI. Tumor classification is achieved by histological and molecular diagnostic assessment of tissue specimens according to the World Health Organization (WHO) classification 2016...
November 29, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29189177/brain-cancer-implication-to-disease-therapeutic-strategies-and-tumor-targeted-drug-delivery-approaches
#15
Viral Shah, Pratiksha Kochar
BACKGROUND: Cancer is one of the leading causes of morbidity and mortality worldwide. Brain cancer is identified as one of the most formidable forms of cancer due to several hurdles posed by the anatomy and physiology of the brain on the therapeutic strategies employed for treating brain cancer. Poor prognosis and high relapse rate further aggravate the situation leading to the high mortality rate in brain cancer. OBJECTIVE: The present review gives a brief insight on different aspects of brain cancer by elucidating its types, causative factors, associated symptoms, diagnostic techniques, treatment strategies and limitations of current treatment strategies...
November 29, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29188215/astroblastoma-in-a-young-female-patient-a-case-report-and-literature-review-of-clinicopathological-radiological-and-prognostic-characteristics-and-current-treatment-strategies
#16
Muhammad Sadiq, Iftikhar Ahmad, Jamila Shuja, Zubair Ahmad, Riyasat Ahmed, Khushnaseeb Ahmad
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm2) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i...
October 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29186607/benefits-and-limitations-of-indocyanine-green-fluorescent-image-guided-surgery-for-spinal-intramedullary-tumors
#17
Toshihiro Takami, Kentaro Naito, Toru Yamagata, Nobuyuki Shimokawa, Kenji Ohata
BACKGROUND: Intraoperative image guidance using near-infrared indocyanine green videoangiography (ICG-VA) has been used to provide real-time angiographic images during vascular or brain tumor surgery, and it is also being used for spine surgery. OBJECTIVE: To further investigate the benefits and limitations of ICG-VA image-guided surgery for spinal intramedullary tumors through retrospective study. METHODS: ICG-VA was used in 48 cases that were treated surgically over the past 5 yr...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29184710/retrospective-study-of-229-surgically-treated-patients-with-brain-metastases-prognostic-factors-outcome-and-comparison-of-recursive-partitioning-analysis-and-diagnosis-specific-graded-prognostic-assessment
#18
Mirza Pojskic, Miriam H A Bopp, Markus Schymalla, Christopher Nimsky, Barbara Carl
Background: Metastases are the most frequent tumors in the brain. Most often used scoring systems to predict the outcome are the RPA (Recursive Partitioning Analysis) classification and the DS-GPA (Diagnosis-Specific Graded Prognostic Assessment) score. The goal of our study was to determine prognostic factors which influence outcome in patients who undergo surgery for brain metastases and to compare different outcome scores. Methods: Two hundred and twenty-nine patients who underwent surgery for brain metastases in our institution between January 2005 and December 2014 were included in the study...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29179472/bcrp-expression-in-schwannoma-plexiform-neurofibroma-and-mpnst
#19
Maurits de Vries, Olaf van Tellingen, Andel G L van der Mey, Antonius M G Bunt, Inge Briaire-de Bruijn, Pancras C W Hogendoorn
Background: peripheral nerve sheath tumors comprise a broad spectrum of neoplasms. Vestibular schwannomas and plexiform neurofibromas are symptomatic albeit benign, but a subset of the latter pre-malignant lesions will transform to malignant peripheral nerve sheath tumors (MPNST). Surgery and radiotherapy are the primary strategies to treat these tumors. Intrinsic resistance to drug therapy characterizes all three tumor subtypes. The breast cancer resistance protein BCRP is a transmembrane efflux transporter considered to play a key role in various biological barriers such as the blood brain barrier...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29177595/practice-patterns-and-survival-outcomes-of-intracranial-germinoma-an-analysis-of-the-national-cancer-database
#20
Wei Gang Wang, Hong Ye, Prakash Chinnaiyan
The goal of the study is to examine the practice pattern and survival outcome of adult and pediatric patients with intracranial germinoma. Patients from the National Cancer Database (NCDB) brain tumor registry between the years 2004-2014 with intracranial germinoma were extracted for analysis. Patients who had distant metastasis, received no treatments, or only surgery/chemotherapy alone were excluded. An age cutoff of > 21 years old was used to define the pediatric population. Patients were stratified by the treatments radiation therapy alone (RT) and chemotherapy followed by radiation therapy (C + RT)...
November 25, 2017: Journal of Neuro-oncology
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