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JOURNAL ARTICLE
Piers Klein, Liqi Shu, Erik Lindgren, Maria A de Winter, James E Siegler, Alexis N Simpkins, Satareh Salehi Omran, Mirjam R Heldner, Adam de Havenon, Mohamad Abdalkader, Sami Al Kasab, Christoph Stretz, Teddy Y Wu, Duncan Wilson, Syed Daniyal Asad, Eyad Almallouhi, Jennifer Frontera, Lindsey Kuohn, Aaron Rothstein, Ekaterina Bakradze, Nils Henninger, Adeel S Zubair, Richa Sharma, Deborah Kerrigan, Yasmin Aziz, Eva A Mistry, Mayte Sanchez van Kammen, Turgut Tatlisumak, Katarzyna Krzywicka, Diana Aguiar de Sousa, Katarina Jood, Thalia S Field, Shadi Yaghi, Jonathan M Coutinho, Thanh N Nguyen
OBJECTIVES: Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2 NCAL2 C score in an international cohort. MATERIALS AND METHODS: The SI2 NCAL2 C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2 NCAL2 C score uses 9 variables: the absence of any female-sex-specific risk factors, intracerebral hemorrhage, central nervous system infection, focal neurological deficits, coma, age, lower level of hemoglobin, higher level of glucose, and cancer...
April 11, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#2
JOURNAL ARTICLE
James E Siegler, Luciano A Sposato, Shadi Yaghi
No abstract text is available yet for this article.
April 8, 2024: JAMA Neurology
#3
JOURNAL ARTICLE
Olivia Sirpilla, R Leo Sakemura, Mehrdad Hefazi, Truc N Huynh, Ismail Can, James H Girsch, Erin E Tapper, Michelle J Cox, Kendall J Schick, Claudia Manriquez-Roman, Kun Yun, Carli M Stewart, Ekene J Ogbodo, Brooke L Kimball, Long K Mai, Omar L Gutierrez-Ruiz, Makena L Rodriguez, Martina Gluscevic, Daniel P Larson, Alex M Abel, Wesley A Wierson, Gloria Olivier, Elizabeth L Siegler, Saad S Kenderian
Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown inconsistent therapeutic efficacy, mostly owing to MSCs providing insufficient immunosuppression in target tissues. Here we show that antigen-specific immunosuppression can be enhanced by genetically modifying MSCs with chimaeric antigen receptors (CARs), as we show for E-cadherin-targeted CAR-MSCs for the treatment of graft-versus-host disease in mice...
April 1, 2024: Nature Biomedical Engineering
#4
JOURNAL ARTICLE
Mudassir Farooqui, Milagros Galecio-Castillo, Ameer E Hassan, Afshin A Divani, Mouhammad Jumaa, Marc Ribo, Nils H Petersen, Michael G Abraham, Johanna T Fifi, Waldo R Guerrero, Amer Malik, James E Siegler, Thanh N Nguyen, Sunil A Sheth, Albert J Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe-Orozco, Wondwossen G Tekle, Sara Y Sabbagh, Syed F Zaidi, Marta Olive Gadea, Ayush Prasad, Abid Qureshi, Reade Andrew De Leacy, Mohamad Abdalkader, Sergio Salazar-Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Aaron Rodriguez-Calienes, Juan Vivanco-Suarez, Maxim Mokin, Dileep R Yavagal, Tudor G Jovin, Santiago Ortega-Gutierrez
BACKGROUND: Endovascular therapy (EVT) stands as an established and effective intervention for acute ischemic stroke in patients harboring tandem lesions (TLs). However, the optimal anesthetic strategy for EVT in TL patients remains unclear. This study aims to evaluate the impact of distinct anesthetic techniques on outcomes in acute ischemic stroke patients presenting with TLs. METHODS: Patient-level data, encompassing cases from 16 diverse centers, were aggregated for individuals with anterior circulation TLs treated between January 2015 and December 2020...
March 1, 2024: Journal of Neurointerventional Surgery
#5
JOURNAL ARTICLE
Adam A Dmytriw, Basel Musmar, Hamza Salim, Sherief Ghozy, James E Siegler, Hassan Kobeissi, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Nicole M Cancelliere, Joshua D Bernstock, Kareem El Naamani, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Thomas R Marotta, Christopher J Stapleton, James D Rabinov, Takahiro Ota, Shogo Dofuku, Leonard Ll Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina Chervak, Achala Vagal, Nimer Adeeb, Hugo H Cuellar-Saenz, Stavropoula I Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Ramanathan Kadirvel, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Ajith J Thomas, Cheng-Yang Hsieh, David S Liebeskind, Răzvan Alexandru Radu, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Robert Fahed, Charlotte Weyland, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego
BACKGROUND: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO. METHODS: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021...
February 26, 2024: European Stroke Journal
#6
JOURNAL ARTICLE
Piers Klein, Liqi Shu, Muhammad M Qureshi, Mohamad Abdalkader, Thalia S Field, James E Siegler, Lily W Zhou, Karan Patel, Sami Al Kasab, Adam de Havenon, Shadi Yaghi, Adnan I Qureshi, Thanh N Nguyen
OBJECTIVES: We sought to provide updated incidence and trend data for cerebral venous thrombosis (CVT) in the United States from 2016-2020, examine the impact of the COVID-19 pandemic on CVT, and identify predictors of in-hospital mortality. MATERIALS AND METHODS: Validated ICD-10 codes were used to identify discharges with CVT in the National Inpatient Sample (NIS). Sample weights were applied to generate nationally representative estimates, and census data were used to compute incidence rates...
February 24, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#7
JOURNAL ARTICLE
Maud Wang, Hans Henkes, Sherief Ghozy, James E Siegler, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Ahmad Sweid, Kareem El Naamani, Robert W Regenhardt, Jose Danilo Bengzon Diestro, Nicole M Cancelliere, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Charlotte Weyland, Thomas R Marotta, Christopher J Stapleton, James D Rabinov, Takahiro Ota, Shogo Dofuku, Leonard Ll Yeo, Benjamin Y Q Tan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Stavropoula I Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M Chervak, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Ajith J Thomas, Cheng-Yang Hsieh, David S Liebeskind, Răzvan Alexandru Radu, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Aman B Patel, Vitor Mendes Pereira, Robert Fahed, Boris Lubicz, Adam A Dmytriw, Adrien Guenego
PURPOSE: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. METHODS: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO...
February 21, 2024: Neuroradiology
#8
JOURNAL ARTICLE
Shadi Yaghi, Liqi Shu, Daniel M Mandel, Christopher R Leon Guerrero, Nils Henninger, Jayachandra Muppa, Muhammad Affan, Omair Ul Haq Lodhi, Mirjam R Heldner, Kateryna Antonenko, David J Seiffge, Marcel Arnold, Setareh Salehi Omran, Ross Curtiss Crandall, Evan Lester, Diego Lopez Mena, Antonio Arauz, Ahmad Nehme, Marion Boulanger, Emmanuel Touzé, João André Sousa, Joao Sargento-Freitas, Vasco Barata, Paulo Castro-Chaves, Maria Teresa Álvares Pereira Brito, Muhib Khan, Dania Mallick, Aaron Rothstein, Ossama Khazaal, Josefin Kaufmann, Stefan T Engelter, Christopher Traenka, Diana Aguiar de Sousa, Mafalda Soares, Sara Db Rosa, Lily W Zhou, Preet Gandhi, Thalia S Field, Steven Mancini, Issa Metanis, Ronen R Leker, Kelly Pan, Vishnu Dantu, Karl Viktor Baumgartner, Tina M Burton, Regina Freiin von Rennenberg, Christian H Nolte, Richard K Choi, Jason A MacDonald, Reza Bavarsad Shahripour, Xiaofan Guo, Malik Ghannam, Mohammad AlMajali, Edgar A Samaniego, Sebastian Sanchez, Bastien Rioux, Faycal Zine-Eddine, Alexandre Y Poppe, Ana Catarina Fonseca, Maria Baptista, Diana Cruz, Michele Romoli, Giovanna De Marco, Marco Longoni, Zafer Keser, Kim J Griffin, Lindsey Kuohn, Jennifer A Frontera, Jordan Amar, James A Giles, Marialuisa Zedde, Rosario Pascarella, Ilaria Grisendi, Hipólito Nzwalo, David S Liebeskind, Amir M Molaie, Annie Cavalier, Wayneho Kam, Brian Mac Grory, Sami Al Kasab, Mohammad Anadani, Kimberly P Kicielinski, Ali Rada Eltatawy, Lina M Chervak, Roberto Chulluncuy-Rivas, Yasmin Ninette Aziz, Ekaterina Bakradze, Thanh Lam Tran, Marc Rodrigo-Gisbert, Manuel Requena, Faddi Ghassan Saleh Velez, Jorge G Ortiz Garcia, Varsha Muddasani, Adam de Havenon, Venugopalan Y Vishnu, Sridhara S Yaddanapudi, Latasha Adams, Abigail Browngoehl, Tamra Ranasinghe, Randy Dunston, Zachary Lynch, Mary Penckofer, James E Siegler, Silvia V Mayer, Joshua Z Willey, Adeel S Zubair, Yee Kuang Cheng, Richa Sharma, João Pedro Marto, Vitor Mendes Ferreira, Piers Klein, Thanh N Nguyen, Syed Daniyal Asad, Zoha Sarwat, Anvesh Balabhadra, Shivam Patel, Thais Leite Secchi, Sheila Co Martins, Gabriel Paulo Mantovani, Young Dae Kim, Balaji Krishnaiah, Cheran Elangovan, Sivani Lingam, Abid Y Qureshi, Sebastian Fridman, Alonso Alvarado-Bolaños, Farid Khasiyev, Guillermo Linares, Marina Mannino, Valeria Terruso, Sofia Vassilopoulou, Vasileios Tentolouris-Piperas, Manuel Martínez-Marino, Víctor A Carrasco Wall, Fransisca Indraswari, Sleiman El Jamal, Shilin Liu, Muhammad Alvi, Farman Ali, Mohammed Madani Sarvath, Rami Z Morsi, Tareq Kass-Hout, Feina Shi, Jinhua Zhang, Dilraj Sokhi, Jamil Said, Alexis N Simpkins, Roberto Gomez, Shayak Sen, Mohammad Ravi Ghani, Marwa Elnazeir, Han Xiao, Narendra Sharma Kala, Farhan Khan, Christoph Stretz, Nahid Mohammadzadeh, Eric D Goldstein, Karen L Furie
Background: Small, randomized trials of cervical artery dissection (CAD) patients showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in patients with CAD treated with antiplatelets versus anticoagulation. Methods: This is a multi-center observational retrospective international study (16 countries, 63 sites) that included CAD patients without major trauma. The exposure was antithrombotic treatment type (anticoagulation vs. antiplatelets) and outcomes were subsequent ischemic stroke and major hemorrhage (intracranial or extracranial hemorrhage)...
February 9, 2024: Stroke; a Journal of Cerebral Circulation
#9
JOURNAL ARTICLE
James E Siegler, Steven Galetta
No abstract text is available yet for this article.
March 12, 2024: Neurology
#10
JOURNAL ARTICLE
James E Siegler, Shyam Prabhakaran
No abstract text is available yet for this article.
February 8, 2024: JAMA
#11
JOURNAL ARTICLE
Thanh N Nguyen, Muhammad M Qureshi, Piers Klein, Hiroshi Yamagami, Mohamad Abdalkader, Robert Mikulik, Anvitha Sathya, Ossama Yassin Mansour, Anna Czlonkowska, Hannah Lo, Thalia S Field, Andreas Charidimou, Soma Banerjee, Shadi Yaghi, James E Siegler, Petra Sedova, Joseph Kwan, Diana Aguiar de Sousa, Jelle Demeestere, Violiza Inoa, Setareh Salehi Omran, Liqun Zhang, Patrik Michel, Davide Strambo, João Pedro Marto, Raul G Nogueira
No abstract text is available yet for this article.
January 2024: Journal of Stroke
#12
JOURNAL ARTICLE
Umika Paul, Manisha Koneru, James E Siegler, Mary Penckofer, Thanh N Nguyen, Jane Khalife, Renato Oliveira, Mohamad Abdalkader, Piers Klein, Nicholas Vigilante, Scott Kamen, Justin Gold, Ajith Thomas, Pratit Patel
OBJECTIVES: Individual subcortical infarct scoring for the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) can be difficult and is subjected to higher inter-reader variability. This study compares performance of the 10-point ASPECTS with a new 7-point cortically-weighted score in predicting post-thrombectomy functional outcomes. MATERIALS AND METHODS: PROSPECTIVE REGISTRY DATA FROM TWO COMPREHENSIVE STROKE CENTERS (SITE 1: 2016-2021; Site 2: 2019-2021) included patients with either M1 segment of middle cerebral artery or internal carotid artery occlusions who underwent thrombectomy...
January 27, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#13
JOURNAL ARTICLE
Nicholas Vigilante, Jane Khalife, Clint A Badger, Hamza Shaikh, Ajith J Thomas, Brian Swendseid, Tudor G Jovin, James E Siegler, Daniel A Tonetti
BACKGROUND: Eagle syndrome is characterized by an elongated styloid process, which can cause acute neurological symptoms when the projection impinges on local structures. One method by which Eagle syndrome can cause acute stroke is via internal carotid artery dissection. OBSERVATIONS: A patient presented with acute aphasia and right-arm weakness. Imaging revealed a left internal carotid artery dissection, which was treated with stenting. Three years later, the patient presented with left-sided weakness, and imaging revealed a new right internal carotid artery dissection...
January 29, 2024: J Neurosurg Case Lessons
#14
JOURNAL ARTICLE
James E Siegler, Steven Galetta
No abstract text is available yet for this article.
February 27, 2024: Neurology
#15
MULTICENTER STUDY
Mohamad Abdalkader, Shen Ning, Muhammad M Qureshi, Diogo C Haussen, Daniel Strbian, Simon Nagel, Jelle Demeestere, Volker Puetz, Mahmoud H Mohammaden, Marta Olive Gadea, Simon Winzer, Hiroshi Yamagami, Kanta Tanaka, João Pedro Marto, Liisa Tomppo, Hilde Henon, Sunil A Sheth, Santiago Ortega-Gutierrez, Nicolas Martinez-Majander, Francois Caparros, Robin Lemmens, Anne Dusart, Flavio Bellante, Syed F Zaidi, James E Siegler, Stefania Nannoni, Johannes Kaesmacher, Tomas Dobrocky, Mudassir Farooqui, Sergio Salazar-Marioni, Pekka Virtanen, Lieselotte Vandewalle, Anke Wouters, Jessica Jesser, Rita Ventura, Alicia C Castonguay, Kazutaka Uchida, Ajit S Puri, Hesham E Masoud, Piers Klein, Zain Mansoor, Jenny Bui, Matthew Kang, Adnan Mujanovic, Federica Rizzo, Tatu Kokkonen, João Nuno Ramos, Davide Strambo, Patrik Michel, Markus A Möhlenbruch, Eugene Lin, Daniel P O Kaiser, Shinichi Yoshimura, Nobuyuki Sakai, Charlotte Cordonnier, Peter A Ringleb, Daniel Roy, Osama O Zaidat, Urs Fischer, Marc Ribo, Jean Raymond, Raul G Nogueira, Thanh N Nguyen
BACKGROUND: The association between sex and outcome after endovascular thrombectomy of acute ischemic stroke is unclear. The aim of this study was to compare the clinical and safety outcomes between men and women treated with endovascular thrombectomy in the late 6-to-24-hour window period. METHODS: This multicenter, retrospective observational cohort study included consecutive patients who underwent endovascular thrombectomy of anterior circulation stroke in the late window from 66 clinical sites in 10 countries from January 2014 to May 2022...
February 2024: Stroke; a Journal of Cerebral Circulation
#16
JOURNAL ARTICLE
Rami Z Morsi, Sonam Thind, Ahmad Chahine, Jehad Zakaria, Harsh Desai, Sachin A Kothari, Atman P Shah, Sandeep Nathan, Elisheva Coleman, Scott Mendelson, James E Siegler, Shyam Prabhakaran, Ali Mansour, Tareq Kass-Hout
BACKGROUND: The use of covered stent grafts for the treatment of carotid rupture is increasingly being used given their ability to preserve the parent artery while simultaneously occluding the fistula or rupture point. METHODS: This case series describes the technical feasibility of using, and the performance of, the PK Papyrus covered coronary stent (Biotronik, Inc., Lake Oswego, Oregon, USA) in six patients with carotid rupture, including carotid cavernous fistulas, between July 2021 and October 2023 in a single-center institution in the USA...
January 3, 2024: Journal of Neurointerventional Surgery
#17
REVIEW
James E Siegler, Steven Galetta
Despite decades of striving to simplify the diagnosis of human death according to irreversible cessation of function of a single organ system-the brain-we are relentlessly plagued by disagreement between experts spanning disciplines from medicine to philosophy. Dr. Bernat summarizes the current state of this controversy in their narrative summary, recently published in Neurology . In this review, the first of a planned series on the Uniform Determination of Death Act (UDDA) and brain death determination in Neurology , Dr...
January 9, 2024: Neurology
#18
JOURNAL ARTICLE
Milagros Galecio-Castillo, Michael Abraham, Mudassir Farooqui, Ameer E Hassan, Afshin A Divani, Mouhammad A Jumaa, Marc Ribo, Nils Petersen, Johanna Fifi, Waldo R Guerrero, Amer M Malik, James E Siegler, Thanh N Nguyen, Sunil A Sheth, Albert J Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe-Orozco, Abid Qureshi, Wondwossen G Tekle, Asad Ikram, Syed F Zaidi, Cynthia B Zevallos, Belen Taborda, Alex Devarajan, Linda Zhang, Mohamad Abdalkader, Sergio Salazar-Marioni, Jazba Soomro, Weston Gordon, Aaron Rodriguez-Calienes, Juan Vivanco-Suarez, Katrina Woolfolk, Maxim Mokin, Dileep R Yavagal, Santiago Ortega-Gutierrez
OBJECTIVE: The optimal technique for treating tandem lesions (TLs) with endovascular therapy is debatable. The authors evaluated the functional, safety, and procedural outcomes of different approaches in a multicenter study. METHODS: Anterior circulation TL patients treated from January 2015 to December 2020 were divided on the basis of antegrade versus retrograde approach and included. The evaluated outcomes were favorable modified Rankin Scale (mRS) score (mRS score 0-2) at 3 months, ordinal shift in mRS score, successful recanalization, excellent recanalization, first-pass effect (FPE), time from groin puncture to successful recanalization, symptomatic intracranial hemorrhage (sICH), and 90-day mortality...
December 29, 2023: Journal of Neurosurgery
#19
JOURNAL ARTICLE
Rami Z Morsi, Yuan Zhang, Meng Zhu, Shitong Xie, Julián Carrión-Penagos, Harsh Desai, Elie Tannous, Sachin A Kothari, Assem Khamis, Andrea J Darzi, Ammar Tarabichi, Reena Bastin, Layal Hneiny, Sonam Thind, James E Siegler, Elisheva R Coleman, Scott J Mendelson, Ali Mansour, Shyam Prabhakaran, Tareq Kass-Hout
Background There is unclear added benefit of intravenous thrombolysis (IVT) with endovascular thrombectomy (EVT). We performed a cost-effectiveness analysis to assess the cost-effectiveness comparing EVT with IVT versus EVT alone. Methods We used a decision tree to examine the short-term costs and outcomes at 90 days after the occurrence of index stroke to compare the cost-effectiveness of EVT alone with EVT plus IVT for patients with stroke. Subsequently, we developed a Markov state transition model to assess the costs and outcomes over 1-year, 5-year, and 20-year time horizons...
December 21, 2023: Neuroepidemiology
#20
JOURNAL ARTICLE
Harsh Desai, Mohammed Maan Al-Salihi, Rami Z Morsi, Omar R Vayani, Sachin A Kothari, Sonam Thind, Julián Carrión-Penagos, Archit Baskaran, Ammar Tarabichi, Veronica A Bonderski, James E Siegler, Mary Hahn, Elisheva R Coleman, James R Brorson, Scott J Mendelson, Ali Mansour, Guilherme Dabus, Michael Hurley, Shyam Prabhakaran, Italo Linfante, Tareq Kass-Hout
BACKGROUND: The optimal antiplatelet therapy regimen for certain neuroendovascular procedures remains unclear. This study investigates the safety and feasibility of intravenous dose-adjusted cangrelor in patients undergoing acute neuroendovascular interventions. METHODS: We conducted a retrospective chart review of all consecutive patients on intravenous cangrelor for neuroendovascular procedures between September 1, 2020, and March 13, 2022. We also conducted an updated systematic review and meta-analysis using PubMed, Scopus, Web of Science, Embase and the Cochrane Library up to February 22, 2023...
2023: Frontiers in Neurology
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