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James e siegler

Whitley W Aamodt, James E Siegler, Angela N Viaene, Michael N Rubenstein
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from infection of oligodendrocytes in the central nervous system with John Cunningham virus. Although PML is commonly diagnosed in immunocompromised patients with human immunodeficiency virus, it can also arise in other immunodeficient states. In this report, we present an unusual case of PML occurring 40years after chemoradiation therapy for Hodgkin lymphoma in a patient with normal total lymphocyte counts on annual surveillance...
May 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Whitley W Aamodt, James E Siegler, Lauren Elman
No abstract text is available yet for this article.
April 25, 2017: Neurology
James E Siegler
No abstract text is available yet for this article.
April 11, 2017: Neurology
Erin C Conrad, James E Siegler, Joanna Mattis, Nilan Schnure, Steven R Messé
No abstract text is available yet for this article.
April 4, 2017: Neurology
James E Siegler, Brenda Banwell, Rebecca N Ichord
No abstract text is available yet for this article.
December 13, 2016: Neurology
James E Siegler, Rebecca N Ichord
No abstract text is available yet for this article.
December 6, 2016: Neurology
James Anaissie, Dominique Monlezun, A Seelochan, James E Siegler, Maria Chavez-Keatts, Jonathan Tiu, Denise Pineda, Alexander George, Amir Shaban, Nidal Abi Rafeh, Laurie Schluter, Sheryl Martin-Schild, Ramy El Khoury
Background. Transesophageal echocardiogram (TEE) is superior to transthoracic echocardiogram (TTE) in detecting left atrial thrombus (LAT), a risk factor for stroke, but is costly and invasive, carrying a higher risk for complications. Aims. To determine the utility of using left atrial enlargement (LAE) on TTE to predict LAT on TEE. Methods. AIS patients who presented in 06/2008-7/2013 and underwent both TTE and TEE were identified from our prospective stroke registry. Analysis consisted of multivariate logistic regression with propensity score adjustment and receiver operating characteristic (ROC) area under the curve (AUC) analyses...
2016: BioMed Research International
James E Siegler, Sheryl Martin-Schild
INTRODUCTION: Although intravenous tissue plasminogen activator (IV tPA) is associated with neurologic deterioration (ND) caused by hemorrhage, whether it attenuates deterioration as a result of other etiologies including progressive stroke remains unexplored. The objective of this study was to determine whether IV tPA is associated with a reduced risk of ND caused by progressive stroke. METHODS: A retrospective investigation of consecutively admitted patients with acute ischemic stroke (July 2008-June 2014) within 4...
October 2016: Southern Medical Journal
James E Siegler, Sarah Flanagan Wesley
No abstract text is available yet for this article.
October 4, 2016: Neurology
James E Siegler, Christy Marcaccio, Kelsey Nawalinski, Francis Quattrone, Danielle K Sandsmark, Eileen Maloney-Wilensky, Suzanne Frangos, Joshua M Levine, Sherman C Stein, Scott E Kasner, Monisha A Kumar
BACKGROUND: Elevated red blood cell distribution width (RDW) has been associated with thrombotic disorders including myocardial infarction, venous thromboembolism, and ischemic stroke, independent of other inflammatory and coagulation biomarkers. The purpose of this study was to determine whether elevated RDW is associated with cerebral infarction and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: In this retrospective single-center cohort of aSAH patients (October 2009-September 2014), elevated RDW was defined as a mean RDW >14...
August 16, 2016: Neurocritical Care
Neha Patel, James E Siegler, Nathaniel Stromberg, Neil Ravitz, C William Hanson
BACKGROUND: In hospitals, effective and efficient communication among care providers is critical to the provision of high-quality patient care. Yet, major problems impede communications including the frequent use of interruptive and one-way communication paradigms. This is especially frustrating for frontline providers given the dynamic nature of hospital care teams in an environment that is in constant flux. METHODS: We conducted a pre-post evaluation of a commercially available secured messaging mobile application on 4 hospital units at a single institution for over one year...
August 10, 2016: Applied Clinical Informatics
James E Anaissie, Dominique J Monlezun, James E Siegler, Elizabeth D Waring, Lauren N Dowell, Alyana A Samai, Alexander J George, Tara Kimbrough, Jimmy Berthaud, Sheryl Martin-Schild
GOAL: To evaluate the safety and efficacy of intravenous (IV) tissue plasminogen activator (tPA) in the treatment of wake-up stroke (WUS) using propensity score (PS) analysis. MATERIALS AND METHODS: Consecutive acute ischemic stroke patients meeting inclusion criteria were retrospectively identified from our stroke registry between July 2008 and May 2014, and classified as stroke onset less than or equal to 4.5 hours treated with tPA (control; n = 369), tPA-treated WUS (n = 46), or nontreated WUS (n = 154)...
November 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
James E Siegler, Amber R Wang, Joshua D Vanderwerf
In this report, we present the case of a 43-year-old woman with AIDS, disseminated aspergillosis, and malnutrition who developed osmotic demyelination syndrome. AIDS-related osmotic demyelination has only been documented in a handful of cases to date, and it appears independent of the classic mechanism of rapid correction of hyponatremia. In this manuscript, we review the six prior cases of osmotic demyelination in AIDS patients and compare their circumstances to that of our own patient. It appears that complications of malnutrition, possibly related to depletion of organic osmolytes in the central nervous system, may place AIDS patients at greater risk of osmotic demyelination...
December 2016: Journal of Neurovirology
James E Siegler, Alyana Samai, Eleanor Semmes, Sheryl Martin-Schild
BACKGROUND AND PURPOSE: Early neurologic deterioration (END) occurs in up to one-third of patients with ischemic stroke and is associated with poor outcomes. The purpose of the present study was to determine which stroke etiologies and vascular distributions pose a greater threat of END in stroke patients. METHODS: Using a single-center registry of prospectively maintained clinical data, adult ischemic stroke patients admitted (July 2008 to June 2014) within 48 hours of symptom onset were evaluated according to stroke etiology and vascular distribution using diffusion-weighted MRI...
May 2016: Journal of Stroke
James E Siegler, Joseph W Kable, Anjan Chatterjee
No abstract text is available yet for this article.
May 2016: Journal of Graduate Medical Education
James E Siegler, Neha N Patel, C Jessica Dine
No abstract text is available yet for this article.
March 2015: Journal of Graduate Medical Education
James E Siegler, Dina A Jacobs, Defne Amado, Jamie L Adams, Joseph R Berger
We report a woman who presented with rapidly progressive dementia and hypoglycorrhachia and discuss the approach and differential diagnosis for her condition. Rapidly progressive dementia poses a variety of challenges to the treating clinician, not only due to the speed of disease progression, but also due to the poor prognosis if intervention is delayed. The differential diagnosis of a patient presenting with rapid cognitive and functional decline is broad and includes degenerative, infectious, toxic, and neoplastic etiologies, some of which can be identified clinically through history and physical examination...
October 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Catherine L Johnson, Roger J Phillips, Michael E Purucker, Brian J Anderson, Paul K Byrne, Brett W Denevi, Joshua M Feinberg, Steven A Hauck, James W Head, Haje Korth, Peter B James, Erwan Mazarico, Gregory A Neumann, Lydia C Philpott, Matthew A Siegler, Nikolai A Tsyganenko, Sean C Solomon
Magnetized rocks can record the history of the magnetic field of a planet, a key constraint for understanding its evolution. From orbital vector magnetic field measurements of Mercury taken by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft at altitudes below 150 kilometers, we have detected remanent magnetization in Mercury's crust. We infer a lower bound on the average age of magnetization of 3.7 to 3.9 billion years. Our findings indicate that a global magnetic field driven by dynamo processes in the fluid outer core operated early in Mercury's history...
May 22, 2015: Science
Christopher G Favilla, Erin Ingala, Jenny Jara, Emily Fessler, Brett Cucchiara, Steven R Messé, Michael T Mullen, Allyson Prasad, James Siegler, Mathew D Hutchinson, Scott E Kasner
BACKGROUND AND PURPOSE: Occult paroxysmal atrial fibrillation (AF) is found in a substantial minority of patients with cryptogenic stroke. Identifying reliable predictors of paroxysmal AF after cryptogenic stroke would allow clinicians to more effectively use outpatient cardiac monitoring and ultimately reduce secondary stroke burden. METHODS: We analyzed a retrospective cohort of consecutive patients who underwent 28-day mobile cardiac outpatient telemetry after cryptogenic stroke or transient ischemic stroke...
May 2015: Stroke; a Journal of Cerebral Circulation
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