Dimitrios Kontis, Eirini Theochari, Helen Fryssira, Spyridon Kleisas, Christalena Sofocleous, Angeliki Andreopoulou, Stamatina Kalogerakou, Anthia Gazi, Lucia Boniatsi, Alexandros Chaidemenos, Eleftheria Tsaltas
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia. In an exploratory study, we hypothesized that the MTHFR 677T allele which has been related to a hypoactive MTHFR enzyme would augment the unfavorable effects of COMT Val158 homozygosity which has been associated with COMT enzyme hyperfunction. 90 schizophrenia patients and 55 healthy volunteers were assessed on psychomotor speed, pattern and spatial recognition memory (SRM), spatial working memory (SWM), attentional flexibility and planning (Stockings of Cambridge-SOC)...
March 14, 2013: Neuroscience Letters