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MTHFR C/T memory

Can Cai, Rong Xiao, Nicholas Van Halm-Lutterodt, Jie Zhen, Xiaochen Huang, Yao Xu, Shuying Chen, Linhong Yuan
BACKGROUND/AIM: Studies have indicated a relationship between either gene polymorphism or in vivo B vitamins' nutritional status with cognition in the elderly. However, the combined effects of MTHFR and SLC19A1gene polymorphism with serum folate and vitamin B12 levels on cognition in Chinese adult population remain unclear. METHODS: Demographic information of 426 Chinese adults aged from 55 to 90 were collected by a well designed self-administered questionnaire...
October 24, 2016: Nutrients
Dimitrios Kontis, Eirini Theochari, Helen Fryssira, Spyridon Kleisas, Christalena Sofocleous, Angeliki Andreopoulou, Stamatina Kalogerakou, Anthia Gazi, Lucia Boniatsi, Alexandros Chaidemenos, Eleftheria Tsaltas
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia. In an exploratory study, we hypothesized that the MTHFR 677T allele which has been related to a hypoactive MTHFR enzyme would augment the unfavorable effects of COMT Val158 homozygosity which has been associated with COMT enzyme hyperfunction. 90 schizophrenia patients and 55 healthy volunteers were assessed on psychomotor speed, pattern and spatial recognition memory (SRM), spatial working memory (SWM), attentional flexibility and planning (Stockings of Cambridge-SOC)...
March 14, 2013: Neuroscience Letters
Shih-Jen Tsai, Chen-Jee Hong, Heng-Liang Yeh, Ying-Jay Liou, Albert C Yang, Mu-En Liu, Jen-Ping Hwang
AIMS: Aging is associated with cognitive deterioration, and genetic factors are implicated in individual cognitive differences in the aged. The C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) yields a common thermolabile variant (T) with reduced enzyme activity and consequent elevation of serum homocysteine concentrations. We designed the present study to investigate whether this functional polymorphism may affect global and specific cognitive functions in older Chinese males without dementia...
2011: Dementia and Geriatric Cognitive Disorders
O J G Schiepers, M P J van Boxtel, S E Harris, A J Gow, A Pattie, C E Brett, R H M de Groot, J Jolles, J M Starr, I J Deary
Low blood levels of B vitamins have been implicated in age-associated cognitive impairment. The present study investigated the association between genetic variation in folate metabolism and age-related cognitive decline in the ninth decade of life. Both the 677C>T (rs1801133) polymorphism and the scarcely studied 1298A>C (rs1801131) polymorphism of the MTHFR gene were assessed in relation to cognitive change over 8 years in older community-dwelling individuals. MTHFR genotype was determined in 476 participants of the Lothian Birth Cohort 1921, whose intelligence was measured in childhood in the Scottish Mental Survey of 1932...
April 2011: Genes, Brain, and Behavior
Joshua L Roffman, Randy L Gollub, Vince D Calhoun, Thomas H Wassink, Anthony P Weiss, Beng C Ho, Tonya White, Vincent P Clark, Jill Fries, Nancy C Andreasen, Donald C Goff, Dara S Manoach
Understanding how risk genes cumulatively impair brain function in schizophrenia could provide critical insights into its pathophysiology. Working memory impairment in schizophrenia has been associated with abnormal dopamine signaling in the prefrontal cortex, which is likely under complex genetic control. The catechol-O-methyltransferase (COMT) 158Val --> Met polymorphism (rs4680), which affects the availability of prefrontal dopamine signaling, consistently stratifies prefrontal activation during working memory performance...
November 11, 2008: Proceedings of the National Academy of Sciences of the United States of America
Osvaldo P Almeida, Leon Flicker, Nicola T Lautenschlager, Peter Leedman, Samuel Vasikaran, Frank M van Bockxmeer
Homocysteine (Hcy) is harmful to neurons and blood vessels, including the cerebral microvasculature. It is possible that such effects contribute to the cascade of events that leads to cognitive decline, dementia, and depression in later life. Hcy is produced during the metabolism of the essential amino-acid methionine, which also involves a methyl group transfer derived from folate and choline metabolism. Its plasma level can be influenced by factors such as age, vitamin deficiency, renal function, and a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, where cytosine is replaced by thymidine (C-->T) at nucleotide position 677...
February 2005: Neurobiology of Aging
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