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https://www.readbyqxmd.com/read/28929594/epicardial-collateral-channel-for-retrograded-recanalization-of-chronic-total-occlusion-percutaneous-coronary-intervention-predictors-of-failure-and-procedural-outcome
#1
Zehan Huang, Dunliang Ma, Bin Zhang, Aba A Folson, Jingye Lin, Kaize Wu, Hongtao Liao, Zhian Zhong
OBJECTIVES: This study set out to identify significant lesion features of chronic total occlusion (CTO) that predict successful retrograde recanalization via epicardial collateral channels (CCs). BACKGROUND: Epicardial CCs remain essential in retrograde percutaneous coronary intervention (PCI) of CTO. However, the unpredictability of success and occurrence of complications limit the application of epicardial CCs for retrograde PCI technique for CTO. METHODS: 103 retro-recanalization cases were analyzed using epicardial CCs with successful recanalization as an end point...
September 19, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28928921/an-unusual-cause-of-genu-valgum-and-persistent-instability
#2
Edward Holloway, Paul Sutton, Robert Cooper
We present the case of a professional adolescent footballer who attended our clinic with ongoing instability symptoms and valgus knee deformity after conservative management of an medial collateral ligament injury. The patient was found to have sustained a contra-coup Salter Harris Type V injury to his lateral distal femur physis resulting in premature growth arrest and deformity. Salter Harris Type V injuries are rare, and often not diagnosed until growth has arrest has occurred due to lack of identifiable features on initial plain radiographs...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28927919/results-of-conservative-follow-up-or-surgical-treatment-of-mayamoya-patients-who-present-without-hemorrhage-tia-or-stroke
#3
Rutao Luo, Faliang Gao, Xiaofeng Deng, Dong Zhang, Yan Zhang
OBJECTIVE: The epidemiology of asymptomatic Moyamoya disease (MMD) is still unclear, and the best management remains controversial. The aim of this study is to evaluate the prognosis of these patients with different management, conservative follow-up or surgical treatment. METHODS: This prospective cohort study screened a series of 696 consecutive MMD patients from 2009 to 2015. Patients with any episodes of hemorrhage and ischemic stroke or TIA were excluded. Finally, 61 patients who were followed up for at least 12 months were included, with 52 patients underwent surgical treatment and 9 patients underwent conservative follow-up...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28927669/are-the-hamstrings-from-the-drive-leg-or-landing-leg-more-active-in-baseball-pitchers-an-electromyographic-study
#4
Brandon J Erickson, Antonia Zaferiou, Peter N Chalmers, Deana Ruby, Phillip Malloy, Timothy J Luchetti, Nikhil N Verma, Anthony A Romeo
BACKGROUND: Ulnar collateral ligament reconstruction (UCLR) has become a common procedure among baseball players of all levels. There are several graft choices in performing UCLR, one of which is a hamstring (gracilis or semitendinosus) autograft. It is unclear whether the hamstring muscle from a pitcher's drive leg (ipsilateral side of the UCLR) or landing leg (contralateral side of the UCLR) is more active during the pitching motion. We hypothesized that the landing leg semitendinosus will be more electromyographically active than the drive leg...
September 15, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28927123/diagnosis-and-surgical-treatment-of-carotid-body-tumor-a-retrospective-analysis-of-58-patients
#5
Qingquan Hua, Zhen Xu, Yang Jiang
The aim of the present study was to illustrate the diagnosis and treatment of carotid body tumor (CBT) based on our experience of previous patients. A total of 58 patients (62 lesions) with CBT who received surgery between October 2003 and October 2013 were included. In total, 17 lesions were categorized into Shamblin grade I, 33 were grade II, and 12 were grade III. Surgical resection of CBT was performed for 52 lesions, resection of CBT and the external carotid artery was performed for 9 lesions, and resection of CBT and the internal carotid artery was performed for 1 lesion...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925377/applied-upper-airway-resistance-instantly-affects-breath-components-a-unique-insight-into-pulmonary-medicine
#6
Pritam Sukul, Jochen Schubert, Svend Kamysek, Phillip Trefz, Wolfram Miekisch
Respiratory parameters such as flow or rate have complex effects onto exhalation of volatile substances and can hamper clinical interpretation of breath biomarkers. We investigated effects of progressively applied upper-airway resistances onto exhalation of volatile organic compounds (VOCs) in healthy humans. We performed real-time mass-spectrometric determination of breath volatiles in 50 subjects with parallel non-invasive hemodynamic monitoring, breath-resolved spirometry and capnometry during controlled tidal breathing (12 breaths/min)...
September 19, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28925313/hemodynamics-and-oxygen-extraction-in-chronic-large-artery-steno-occlusive-disease-clinical-applications-for-predicting-stroke-risk
#7
Colin P Derdeyn
Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined compensatory mechanisms to reduced pressure or flow - autoregulatory vasodilation and increased oxygen extraction fraction. Other changes, such as metabolic downregulation, are likely. The positive identification of autoregulatory vasodilation and increased oxygen extraction fraction in humans is an established risk factor for future ischemic stroke in some disease states such as atherosclerotic carotid stenosis and occlusion...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28924998/pulmonary-vein-stenosis-with-collateralization-via-esophageal-varices-long-term-follow-up-after-successful-treatment-with-drug-eluting-stent
#8
Jason F Goldberg, Craig L Jensen, Rajesh Krishnamurthy, Nidhy P Varghese, Henri Justino
OBJECTIVE: We describe the long-term follow-up of a child with recurrent hemoptysis due to severe pulmonary vein stenosis decompressing via collaterals to esophageal varices. DESIGN: Case report SETTING: Tertiary children's hospital PATIENT: Single child through ages 2- to 11-year old INTERVENTIONS: The child underwent cutting balloon angioplasty, bare metal stenting, and implantation of a PTFE-covered stent, all of which failed rapidly. Only after placement of a paclitaxel drug eluting stent did he have prolonged relief from hemoptysis and long-term patency of the treated vein...
September 18, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28924100/acquired-collateral-venous-pathways-in-a-dog-with-cranial-vena-cava-obstruction
#9
Mario Ricciardi, Marcello Lanci
An 8-year-old neutered female Yorkshire terrier with mediastinal neoplasm and subsequent cranial vena cava invasion developed multiple venous collaterals from the brachiocephalic venous trunks to the caudal vena cava. Collateral venous pathways have been described in dogs with obstruction or increased blood flow resistance of the caudal vena cava but cranial vena cava collaterals have not been reported until now in veterinary patients. In this report, the CTA characteristics of such peculiar vascular routes are described and compared to similar findings reported in human medical literature...
September 15, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28924068/-endovascular-treatment-for-carotid-blowout-syndrome-after-radiation-for-esophageal-cancer-a-case-report
#10
Shigefumi Takahashi, Tomohiro Kawaguchi, Kuniyasu Niizuma, Atsuhiro Nakagawa, Miki Fujimura, Takenori Ogawa, Yukio Katori, Teiji Tominaga
Here, we discuss a case of carotid blowout syndrome successfully treated with endovascular parent artery occlusion. A 71-year-old woman underwent treatment for esophageal cancer resection, followed by 50-Gy radiotherapy, 19 years prior. Due to local recurrence, she underwent 66- and 72-Gy radiation treatments at 2 and 4 years after the initial treatment, respectively. Afterward, tracheostomy and enterostomy were performed. This time, she was transported to our emergency department because of acute eruptive bleeding from the tracheal tube...
September 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28924012/inhibition-of-il-1%C3%AE-signaling-normalizes-nmda-dependent-neurotransmission-and-reduces-seizure-susceptibility-in-a-mouse-model-of-creutzfeldt-jakob-disease
#11
Ilaria Bertani, Valentina Iori, Massimo Trusel, Mattia Maroso, Claudia Foray, Susanna Mantovani, Raffaella Tonini, Annamaria Vezzani, Roberto Chiesa
Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein (PrP) misfolding, clinically recognized by cognitive and motor deficits, electroencephalographic (EEG) abnormalities and seizures. Its neurophysiological bases are not known. To assess the potential involvement of N-methyl-D-aspartate receptor (NMDAR) dysfunction, we analyzed NMDA-dependent synaptic plasticity in hippocampal slices from Tg(CJD) mice, which model a genetic form of CJD. Because PrP depletion may result in functional upregulation of NMDARs, we also analyzed PrP knockout (KO) mice...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923629/multidetector-computed-tomography-findings-of-splenic-artery-aneurysms-associated-with-liver-involvement-in-wilson-s-disease
#12
M Özdemir, R S Ökten, F Küçükay, M Ereren, F A E Özdemir, M Akdoğan, S Kaçar, E B Bostancı
PURPOSE: The purposed of this study was to examine the incidence and multidetector computed tomography (MDCT) findings of splenic artery aneurysms (SAAs) in patients with liver involvement related to Wilson's disease. METHODS: Eighteen patients with clinically and/or pathologically proven Wilson's disease underwent triphasic MDCT. Arterial, portal, and equilibrium phase images were obtained. The analysis of the CT features included the presence and characteristics of the SAA, splenic artery (SA) diameter, the presence and size of the portosystemic collateral vessels, and spleen volume...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923531/hippocampal-infarction-identification-of-three-new-types
#13
A Förster, M Al-Zghloul, P Eisele, H Wenz, J Böhme, C Groden, E Neumaier-Probst
BACKGROUND AND PURPOSE: Hippocampal infarction (HI) is common but yet still not comprehensively studied. In the present study, we aimed to identify novel HI patterns and to describe additional ischemic lesions outside the hippocampus to draw conclusions regarding the underlying vessel occlusion. METHODS: In 222 patients (mean age 69.9 (±13.6) years; 129 (58.1%) male, 93 (41.9%) female) with HI, diffusion-weighted images were analyzed with emphasis on HI patterns and associated ischemic lesions outside the hippocampus...
September 15, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28922902/from-directed-donation-to-kidney-sale-does-the-argument-hold-up
#14
James Stacey Taylor
The UCLA Medical Center has initiated a "voucher program" under which a person who donated a kidney would receive a voucher that she could provide to someone of her choosing who could then use it to move to the top of the renal transplantation waiting list. If the use of such vouchers as incentives for donors is morally permissible, then cash payments for kidneys are also morally permissible. But, that argument faces five objections. First, there are some goods whose nature allows them to be exchanged for similar goods but renders them monetarily inalienable...
October 1, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28920170/meniscal-extrusion-seen-on-ultrasonography-affects-the-development-of-radiographic-knee-osteoarthritis-a-3-year-prospective-cohort-study
#15
Daisuke Chiba, Shugo Maeda, Eiji Sasaki, Seiya Ota, Shigeyuki Nakaji, Eiichi Tsuda, Yasuyuki Ishibashi
The objective of this study is to determine whether meniscal extrusion (ME) of the medial meniscus on ultrasonography affects knee osteoarthritis (KOA) progression during 3-year follow-up. Two hundred seventy volunteers (70 men, 200 women; mean age 60.5 years) participated. Weight-bearing radiographs were evaluated. All subjects had medial radiographic KOA (Kellgren-Lawrence grade [KLG], ≥ 2) in at least one knee at baseline (BL). KLG 2 was defined as moderate KOA (MKOA); KLG 3 and 4 were defined as severe KOA (SKOA)...
September 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28920103/existence-of-brain-5-ht1a-5-ht2a-isoreceptor-complexes-with-antagonistic-allosteric-receptor-receptor-interactions-regulating-5-ht1a-receptor-recognition
#16
Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are targets for treatment. The therapeutic action of serotonin-selective reuptake inhibitors is of proven effectiveness, but the mechanisms underlying their effect are still unclear. There are many 5-HT subtypes involved; some need to be blocked (e.g., 5-HT2A, 5-HT3, and 5-HT7), whereas others need to be activated (e...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28918822/a-theoretical-model-to-explain-the-smart-technology-adoption-behaviors-of-elder-consumers-elderadopt
#17
Stephen M Golant
A growing global population of older adults is potential consumers of a category of products referred to as smart technologies, but also known as telehealth, telecare, information and communication technologies, robotics, and gerontechnology. This paper constructs a theoretical model to explain whether older people will adopt smart technology options to cope with their discrepant individual or environmental circumstances, thereby enabling them to age in place. Its proposed constructs and relationships are drawn from multiple academic disciplines and professional specialties, and an extensive literature focused on the factors influencing the acceptance of these smart technologies...
August 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28917976/low-molecular-weight-fucoidan-ameliorates-hindlimb-ischemic-injury-in-type-2-diabetic-rats
#18
Zhiqiang Wang, Tiantian Liu, Xiaoping Chen, Hongjie You, Quanbin Zhang, Jingyi Xue, Yuanyuan Zheng, Dali Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional Chinese medicine, commonly used to alleviate edema, particularly for feet with numbness and pain. AIM OF THE STUDY: Diabetic mellitus (DM) patients are at high risk of developing peripheral arterial disease (PAD). Individuals with DM and PAD co-morbidity have a much higher risk of critical limb ischemia. LMWF showed several beneficial effects, such as anti-inflammation, anti-thrombosis, and enhancing revascularization...
September 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28917580/the-influence-of-ligament-modelling-strategies-on-the-predictive-capability-of-finite-element-models-of-the-human-knee-joint
#19
Hamid Naghibi Beidokhti, Dennis Janssen, Sebastiaan van de Groes, Javad Hazrati, Ton Van den Boogaard, Nico Verdonschot
In finite element (FE) models knee ligaments can represented either by a group of one-dimensional springs, or by three-dimensional continuum elements based on segmentations. Continuum models closer approximate the anatomy, and facilitate ligament wrapping, while spring models are computationally less expensive. The mechanical properties of ligaments can be based on literature, or adjusted specifically for the subject. In the current study we investigated the effect of ligament modelling strategy on the predictive capability of FE models of the human knee joint...
September 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28916520/rubrocerebellar-feedback-loop-isolates-the-interposed-nucleus-as-an-independent-processor-of-corollary-discharge-information-in-mice
#20
Christy S Beitzel, Brenda D Houck, Samantha M Lewis, Abigail L Person
Understanding cerebellar contributions to motor coordination requires deeper insight into how the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence downstream motor pathways. The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes...
September 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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