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https://www.readbyqxmd.com/read/28738486/-association-between-collateral-circulation-and-myocardial-viability-evaluated-by-cardiac-magnetic-resonance-imaging-in-patients-with-coronary-artery-chronic-total-occlusion
#1
J N Li, L J Zhang, Y He, Y L Chen, R C Huang, S Z Lyu, X T Song
Objective: Late gadolinium enhancement(LGE) cardiac magnetic resonance imaging(CMR) was used to evaluate the myocardial viability of chronic total occlusion(CTO) in patients with coronary heart disease and to observe the relationship between collateral circulation and myocardium viability in these patients. Methods: This retrospective study included 40 patients with CTO diagnosed by invasive coronary angiography (CAG) from September 2015 to June 2016 in our department, all patients performed CMR examination within one week after CAG...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738083/the-influence-of-sex-and-trauma-impact-on-the-rupture-site-of-the-ulnar-collateral-ligament-of-the-thumb
#2
Sandra Boesmueller, Wolfgang Huf, Gregor Rettl, Falko Dahm, Alexander Meznik, Gabriela Muschitz, Hugo Kitzinger, Adam Bukaty, Christian Fialka, Martin Vierhapper
PURPOSE AND HYPOTHESIS: Although sex- and gender-specific analyses have been gaining more attention during the last years they have rarely been performed in orthopaedic literature. The primary purpose of this study was to investigate whether for injuries of the UCL the specific location of the rupture is influenced by sex. A secondary study question addressed the sex-independent effect of trauma intensity on the rupture site of the UCL. METHODS: This study is a retrospective analysis of all patients with either a proximal or distal bony avulsion or with a mid-substance tear or ligament avulsion of the UCL treated surgically between 1992 and 2015 at two level-I trauma centres...
2017: PloS One
https://www.readbyqxmd.com/read/28737782/ferrocene-cinchona-hybrids-with-triazolyl-chalcone-linkers-act-as-pro-oxidants-and-sensitize-human-cancer-cell-lines-to-paclitaxel
#3
Ana Podolski-Renić, Szilvia Bősze, Jelena Dinić, László Kocsis, Ferenc Hudecz, Antal Csámpai, Milica Pešić
Recently, we demonstrated that ferrocene-containing compounds with a cinchona moiety displayed marked anticancer activity. Here we report on the effects of the most promising isomers encompassing quinine- (compounds 4 and 5) and quinidine-epimers (compounds 6 and 7) - synthesized using improved methods providing controlled diastereoselectivity - in three different human multidrug resistant (MDR) cancer cell lines and their sensitive counterparts (non-small cell lung carcinoma NCI-H460/R/NCI-H460, colorectal carcinoma DLD1-TxR/DLD1 and glioblastoma U87-TxR/U87)...
July 24, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28736114/flow-diversion-within-seven-days-after-stroke-onset-is-associated-with-favorable-outcome-in-anterior-circulation-stroke
#4
Fei Wu, Wenjie Cao, Yifeng Ling, Lumeng Yang, Xin Cheng, Qiang Dong
Anterior cerebral artery (ACA) flow diversion (FD), defined as ipsilateral mean velocity (MV) of at least 30% greater than the contralateral artery, could be seen an indirect sign of leptomeningeal collateralization in the setting of middle cerebral artery occlusion. The purpose of the study was to evaluate the association between dynamic FD and functional outcome in acute anterior stroke patients with large artery occlusion. Acute middle cerebral artery (MCA) or internal carotid artery (ICA) occlusive stroke patients within 12h were recruited...
July 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28735845/anterior-and-posterior-bands-of-the-anterior-bundle-in-the-elbow-ulnar-collateral-ligament-ultrasound-anatomy
#5
Masahito Yoshida, Hideyuki Goto, Tetsuya Takenaga, Atsushi Tsuchiya, Katsumasa Sugimoto, Volker Musahl, Freddie Fu, Takanobu Otsuka
BACKGROUND: The anterior oblique bundle (AOL) of the ulnar collateral ligament (UCL) is composed of anterior and posterior bands. This study evaluated the anatomy of the anterior and posterior bands in the AOL of the UCL for their separate visualization with ultrasound (US). METHODS: We dissected 18 cadaveric elbow joints and recorded the direction of each band from the lateral view to determine the proper position for the US transducer. To determine the proper inclination of the transducer, we measured the inclinations of each band at the proximal and distal insertions from the transverse view...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28734719/coronoid-reconstruction-using-osteochondral-grafts-a-biomechanical-study
#6
Enrico Bellato, Youngbok Kim, James S Fitzsimmons, Lawrence J Berglund, Alexander W Hooke, Daniel R Bachman, Shawn W O'Driscoll
HYPOTHESIS: The purposes of this study were to test the hypothesis that coronoid deficiency in the setting of posteromedial rotatory instability (PMRI) must be reconstructed to restore articular contact pressures to normal and to compare 3 different osteochondral grafts for this purpose. METHODS: After creation of a anteromedial fracture, six cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and to passively flex the elbow...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28734533/changes-in-pitching-mechanics-after-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers
#7
Daniel A Portney, Jake M Lazaroff, Lucas T Buchler, Stephen M Gryzlo, Matthew D Saltzman
BACKGROUND: Medial ulnar collateral ligament (UCL) reconstruction is a common procedure performed on Major League Baseball pitchers. Variations in pitching mechanics before and after UCL reconstructive surgery are not well understood. METHODS: Publicly available pitch tracking data (PITCHf/x) were compared for all Major League Baseball pitchers who underwent UCL reconstruction between 2008 and 2013. Specific parameters analyzed were fastball percentage, release location, velocity, and movement of each pitch type...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28731633/australian-consumer-awareness-of-health-benefits-associated-with-vegetable-consumption
#8
Reetica Rekhy, Aila Khan, Jocelyn Eason, Hazel Mactavish-West, Carolyn Lister, Robyn Mcconchie
AIM: The present study investigated the perceived health benefits of specific vegetable consumption to guide the use of nutrition and health claims on vegetable marketing collateral. METHODS: Free elicitation and consumer ranking data were collected through an online survey of 1000 adults from across Australia and analysed for the perceived importance of vegetables in the daily diet, number of serves consumed per day, knowledge about health-related benefits of specific vegetables and perceived health benefits of vegetable consumption...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28730863/non-operative-management-of-ulnar-collateral-ligament-injuries-in-the-throwing-athlete
#9
Mia Smucny, Robert W Westermann, Matthew Winters, Mark S Schickendantz
Medial ulnar collateral ligament (UCL) injuries have become increasingly prevalent in overhead athletes. The orthopaedic literature contains a wealth of information on operative management of these injuries. However, there are few high-quality longitudinal studies on non-operative care of UCL injuries. The purpose of this review is to describe the non-operative approach to managing UCL injuries, including recommended rehabilitation strategies and predictors of successful non-operative treatment.
July 21, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28730295/incarceration-of-the-medial-collateral-ligament-in-the-intercondylar-notch-following-proximal-avulsion
#10
Edward Walton, Martin Williams, James R Robinson
Intra-articular entrapment of the medial collateral ligament (MCL) is a rare but recognised complication of traumatic injury to the posteromedial corner (PMC) of the knee. Considering the MCL is the most commonly injured ligament of the knee this complication is extremely rare with only a handful of cases describing MCL entrapment following distal avulsion of the MCL. We present the first known case of MCL entrapment following proximal avulsion of the MCL and posterior oblique ligament (POL) with the mid-substance of the MCL becoming entrapped in the joint, lying on the superior surface of the medial meniscus and extending up into the intercondylar notch...
July 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28729755/social-cognition-deficits-current-position-and-future-directions-for-neuropsychological-interventions-in-cerebrovascular-disease
#11
REVIEW
Progress Njomboro
Neuropsychological assessments of cognitive dysfunction in cerebrovascular illness commonly target basic cognitive functions involving aspects of memory, attention, language, praxis, and number processing. Here, I highlight the clinical importance of often-neglected social cognition functions. These functions recruit a widely distributed neural network, making them vulnerable in most cerebrovascular diseases. Sociocognitive deficits underlie most of the problematic social conduct observed in patients and are associated with more negative clinical outcomes (compared to nonsocial cognitive deficits)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28726678/collateral-contamination-concomitant-to-the-polonium-210-poisoning-of-mr-alexander-litvinenko
#12
John D Harrison, Tracy Smith, Tim Fell, Jenny Smith, George Ham, Richard Haylock, Alan Hodgson, George Etherington
Mr Litvinenko died on 23rd November 2006, having been poisoned with polonium-210 on 1st November, with evidence of a previous poisoning attempt during October 2006. Measurements of 210Po in urine samples were made for a large number of people to determine whether they may have been contaminated. In the majority of cases, measured levels were attributable to the presence of 210Po from normal dietary sources. For a small number of cases, elevated levels provided evidence of direct contamination associated with the poisonings...
July 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28726522/steerable-induction-of-the-thymosin-%C3%A3-4-mrtf-a-pathway-via-aav-based-overexpression-induces-therapeutic-neovascularization
#13
Tilman Ziegler, Markus Kraus, Wira Husada, Florian Gesenhues, Qui Jiang, Olaf Pinkenburg, Teresa Trenkwalder, Karl-Ludwig Laugwitz, Ferdinand le Noble, Christian Weber, Christian Kupatt, Rabea Hinkel
Viral vectors have been frequently used in a variety of preclinical animal models to deliver genetic constructs into tissues. Among the vectors used, adeno-associated viral vectors (AAVs) may be targeted to specific tissues, depending on the serotype used. Moreover, they show robust expression for prolonged periods of time and have a low immunogenic potential. Furthermore, AAVs, unlike other vector systems, only display a low rate of genomic integration. However, to ensure efficient transgene production, expression is typically driven by constitutively active promoters, such as the CMV promotor...
July 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28726308/the-collateral-venous-system-in-late-pregnancy-a-systematic-review-of-the-literature
#14
REVIEW
Aimee Humphries, Peter Stone, S Ali Mirjalili
INTRODUCTION: Recent literature has reported an association between maternal supine sleep position and stillbirth during late pregnancy. In this position the gravid uterus almost completely obstructs the inferior vena cava. A small number of women experience supine hypotension, thought to be due in part to inadequate collateral venous circulation. The aim of this paper is to review the literature describing the anatomy of the collateral venous system and in particular the azygos system, the abdominal portion of which has not been well studied...
July 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28725917/double-inter-internal-carotid-artery-communication-through-intercavernous-anastomosis-and-posterior-communicating-artery-associated-with-multiple-intracranial-artery-segmental-agenesis-aplasia
#15
Yae Won Park, Joonsang Yoo, Dong Joon Kim
Segmental internal carotid artery (ICA) and basilar artery (BA) agenesis/aplasia are rare vascular anomalies. We report an extremely rare case of combined ICA, BA, and A1 segmental absence presenting with double inter-ICA collateral communication through the intercavernous anastomosis and posterior communicating arteries. The patient presented with diplopia and transient ischemic attack. The pathogenesis of the anatomic anomalies and clinical symptoms are discussed.
July 19, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28724418/improved-recovery-of-regional-left-ventricular-function-after-pci-of-chronic-total-occlusion-in-stemi-patients-a-cardiovascular-magnetic-resonance-study-of-the-randomized-controlled-explore-trial
#16
Joëlle Elias, Ivo M van Dongen, Loes P Hoebers, Dagmar M Ouweneel, Bimmer E P M Claessen, Truls Råmunddal, Peep Laanmets, Erlend Eriksen, René J van der Schaaf, Dan Ioanes, Robin Nijveldt, Jan G Tijssen, Alexander Hirsch, José P S Henriques
BACKGROUND: The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) of the concurrent chronic total occlusion (CTO) in ST-segment elevation myocardial infarction (STEMI) patients on global left ventricular (LV) systolic function. However a possible treatment effect will be most pronounced in the CTO territory. Therefore, we aimed to study the effect of CTO PCI compared to no-CTO PCI on the recovery of regional LV function, particularly in the CTO territory...
July 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28722015/trpv1-regulates-excitatory-innervation-of-olm-neurons-in-the-hippocampus
#17
Joaquin I Hurtado-Zavala, Binu Ramachandran, Saheeb Ahmed, Rashi Halder, Christiane Bolleyer, Ankit Awasthi, Markus A Stahlberg, Robin J Wagener, Kristin Anderson, Ryan M Drenan, Henry A Lester, Julie M Miwa, Jochen F Staiger, Andre Fischer, Camin Dean
TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. However, the location and function of TRPV1 in the hippocampus is debated. We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory innervation. TRPV1 knockout mice have reduced glutamatergic innervation of OLM neurons. When activated by capsaicin, TRPV1 recruits more glutamatergic, but not GABAergic, terminals to OLM neurons in vitro...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719556/inadvertent-harvest-of-the-median-nerve-instead-of-the-palmaris-longus-tendon
#18
Bruce M Leslie, A Lee Osterman, Scott W Wolfe
BACKGROUND: The palmaris longus tendon is frequently used as a tendon graft or ligament replacement. In rare instances the median nerve has been inadvertently harvested instead of the palmaris longus for use as a tendon. METHODS: Nineteen cases in which the median nerve had been mistakenly harvested instead of the palmaris longus tendon were collected from members of the American Society for Surgery of the Hand (ASSH) Listserve. Surgeons involved in the subsequent care of the subject who had had an inadvertent harvest were contacted or the chart was reviewed...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28718336/coexistence-of-takayasu-s-arteritis-and-ankylosing-spondylitis-may-not-be-accidental-is-there-a-need-for-a-new-subgroup-in-the-spondyloarthritis-family
#19
Pawel Mielnik, Anja Myhre Hjelle, Jan Leidulv Nordeide
Aortitis of ascending aorta is a recognized complication of ankylosing spondylitis (AS). There are a few published cases of diffuse aortitis and aorta collaterals inflammation that fulfill Takayasu's arteritis (TA) criteria coexisting with AS. We have reviewed published cases from literature and present three new cases of such coexistence. We identified three patients who fulfilled definite AS New York criteria in our Takayasu's vasculitis cohort of eight patients. One of this patients had been diagnosed with Crohn's disease before AS and TA diagnosis...
July 18, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28718330/anatomic-assessment-of-k-wire-trajectory-for-transverse-percutaneous-fixation-of-small-finger-metacarpal-fractures-a-cadaveric-study
#20
Louis C Grandizio, Amy Speeckaert, Zach Kozick, Joel C Klena
BACKGROUND: The purpose of this cadaveric study is to evaluate the trajectory of percutaneous transverse Kirschner wire (K-wire) placement for fifth metacarpal fractures relative to the sagittal profile of the fifth metacarpal in order to develop a targeting strategy for the treatment of fifth metacarpal fractures. METHODS: Using 12 unmatched fresh human upper limbs, we evaluated the trajectory of percutaneous transverse K-wire placement relative to the sagittal profile of the fifth metacarpal in order to develop a targeting strategy for treatment of fifth metacarpal fractures...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
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