keyword
https://read.qxmd.com/read/38626588/impact-of-neoadjuvant-chemotherapy-on-short-term-outcomes-after-simple-and-complex-minimally-invasive-minor-hepatectomy-for-colorectal-liver-metastases-a-propensity-score-matched-and-coarsened-exact-matched-study
#1
JOURNAL ARTICLE
Tijs J Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L Aghayan, Andrew G R Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong Duy Long, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I Troisi, Ho Seong Han, Tan To Cheung, Atsushi Sugioka, Safi Dokmak, Kuo Hsin Chen, Rong Liu, David Fuks, Wanguang Zhang, Luca Aldrighetti, Bjørn Edwin, Brian K P Goh
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone...
April 2, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38609939/identification-and-support-of-autistic-individuals-within-the-uk-criminal-justice-system-a-practical-approach-based-upon-professional-consensus-with-input-from-lived-experience
#2
JOURNAL ARTICLE
Emma Woodhouse, Jack Hollingdale, Lisa Davies, Zainab Al-Attar, Susan Young, Luke P Vinter, Kwaku Agyemang, Carla Bartlett, Colleen Berryessa, Eddie Chaplin, Quinton Deeley, Ian Freckelton, Felicity Gerry, Gisli Gudjonsson, Katie Maras, Michelle Mattison, Jane McCarthy, Richard Mills, Peter Misch, David Murphy, Clare Allely
BACKGROUND: Autism spectrum disorder (hereafter referred to as autism) is characterised by difficulties with (i) social communication, social interaction, and (ii) restricted and repetitive interests and behaviours. Estimates of autism prevalence within the criminal justice system (CJS) vary considerably, but there is evidence to suggest that the condition can be missed or misidentified within this population. Autism has implications for an individual's journey through the CJS, from police questioning and engagement in court proceedings through to risk assessment, formulation, therapeutic approaches, engagement with support services, and long-term social and legal outcomes...
April 12, 2024: BMC Medicine
https://read.qxmd.com/read/38589621/large-scale-phenotyping-of-patients-with-long-covid-post-hospitalization-reveals-mechanistic-subtypes-of-disease
#3
JOURNAL ARTICLE
Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K Sidhu, Stephanie Ascough, Shona C Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Matthew Thorpe, A A Roger Thompson, Sarah L Rowland-Jones, Annemarie B Docherty, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S Howard, Daniel G Wootton, Jennifer K Quint, Thushan I de Silva, Antonia Ho, Christopher Chiu, Ewen M Harrison, William Greenhalf, J Kenneth Baillie, Malcolm G Semple, Lance Turtle, Rachael A Evans, Louise V Wain, Christopher Brightling, Ryan S Thwaites, Peter J M Openshaw
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment...
April 2024: Nature Immunology
https://read.qxmd.com/read/38561848/correction-to-a-double-blind-placebo-controlled-randomized-trial-of-pxt3003-for-the-treatment-of-charcot-marie-tooth-type-1a
#4
Shahram Attarian, Peter Young, Thomas H Brannagan, David Adams, Philip Van Damme, Florian P Thomas, Carlos Casanovas, Jafar Kafaie, Céline Tard, Maggie C Walter, Yann Péréon, David Walk, Amro Stino, Marianne de Visser, Camiel Verhamme, Anthony Amato, Gregory Carter, Laurent Magy, Jeffrey M Statland, Kevin Felice
No abstract text is available yet for this article.
April 1, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38506796/ticagrelor-or-clopidogrel-monotherapy-vs-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-a-systematic-review-and-patient-level-meta-analysis
#5
JOURNAL ARTICLE
Marco Valgimigli, Felice Gragnano, Mattia Branca, Anna Franzone, Bruno R da Costa, Usman Baber, Takeshi Kimura, Yangsoo Jang, Joo-Yong Hahn, Qiang Zhao, Stephan Windecker, Charles M Gibson, Hirotoshi Watanabe, Byeong-Keuk Kim, Young Bin Song, Yunpeng Zhu, Pascal Vranckx, Shamir Mehta, Kenji Ando, Sung Jin Hong, Hyeon-Cheol Gwon, Patrick W Serruys, George D Dangas, Eùgene P McFadden, Dominick J Angiolillo, Dik Heg, Paolo Calabrò, Peter Jüni, Roxana Mehran
IMPORTANCE: Among patients undergoing percutaneous coronary intervention (PCI), it remains unclear whether the treatment efficacy of P2Y12 inhibitor monotherapy after a short course of dual antiplatelet therapy (DAPT) depends on the type of P2Y12 inhibitor. OBJECTIVE: To assess the risks and benefits of ticagrelor monotherapy or clopidogrel monotherapy compared with standard DAPT after PCI. DATA SOURCES: MEDLINE, Embase, TCTMD, and the European Society of Cardiology website were searched from inception to September 10, 2023, without language restriction...
March 20, 2024: JAMA Cardiology
https://read.qxmd.com/read/38470089/the-optimal-number-of-induction-chemotherapy-cycles-in-clinically-lymph-node-positive-bladder-cancer
#6
JOURNAL ARTICLE
Markus von Deimling, Laura S Mertens, Marc Furrer, Roger Li, Guus A H Tendijck, Jacob Taylor, Felice Crocetto, Moritz Maas, Andrea Mari, Renate Pichler, Marco Moschini, Karl H Tully, David D'Andrea, Ekaterina Laukhtina, Francesco Del Giudice, Gautier Marcq, Maud Velev, Andrea Gallioli, Simone Albisinni, Keiichiro Mori, Abhinav Khanna, Michael Rink, Margit Fisch, Andrea Minervini, Peter C Black, Yair Lotan, Philippe E Spiess, Bernhard Kiss, Shahrokh F Shariat, Benjamin Pradere
OBJECTIVE: To investigate the optimal number of induction chemotherapy cycles needed to achieve a pathological response in patients with clinically lymph node-positive (cN+) bladder cancer (BCa) who received three or four cycles of induction chemotherapy followed by consolidative radical cystectomy (RC) with pelvic lymph node dissection. PATIENTS AND METHODS: We included 388 patients who received three or four cycles of cisplatin/gemcitabine or (dose-dense) methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC), followed by consolidative RC for cTanyN1-3M0 BCa...
March 12, 2024: BJU International
https://read.qxmd.com/read/38454470/correction-strategies-to-improve-care-for-older-adults-who-present-to-the-emergency-department-a-systematic-review
#7
Luke Testa, Lieke Richardson, Colleen Cheek, Theresa Hensel, Elizabeth Austin, Mariam Safi, Natália Ransolin, Ann Carrigan, Janet Long, Karen Hutchinson, Magali Goirand, Mia Bierbaum, Felicity Bleckly, Peter Hibbert, Kate Churruca, Robyn Clay-Williams
No abstract text is available yet for this article.
March 7, 2024: BMC Health Services Research
https://read.qxmd.com/read/38450913/utilising-organs-from-hepatitis-c-virus-pcr-positive-donors-in-western-australia
#8
JOURNAL ARTICLE
Peter Boan, Jagadish Jamboti, Michael Musk, Melanie Lavender, Jeremy P Wrobel, Felicity Lee, Amit Shah, Lynette A Pereira, J Owen Robinson, Ashley Irish
We transplanted six solid organs from three hepatitis C virus (HCV) polymerase chain reaction (PCR)-positive donors during 2018-2023. Recipients were treated with glecaprevir/pibrentasvir or sofosbuvir/velpatasvir for 4-12 weeks, with all six achieving sustained virological response without significant adverse events. As occurs in other jurisdictions, solid organ transplants from HCR PCR-positive donors can be safely utilised in Australia.
March 7, 2024: Internal Medicine Journal
https://read.qxmd.com/read/38398180/evaluation-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-samples-from-advanced-non-small-cell-lung-cancer-for-whole-genome-whole-exome-and-comprehensive-panel-sequencing
#9
JOURNAL ARTICLE
David Fielding, Vanessa Lakis, Andrew J Dalley, Haarika Chittoory, Felicity Newell, Lambros T Koufariotis, Ann-Marie Patch, Stephen Kazakoff, Farzad Bashirzadeh, Jung Hwa Son, Kimberley Ryan, Daniel Steinfort, Jonathan P Williamson, Michael Bint, Carl Pahoff, Phan Tien Nguyen, Scott Twaddell, David Arnold, Christopher Grainge, Andrew Pattison, David Fairbairn, Shailendra Gune, Jemma Christie, Oliver Holmes, Conrad Leonard, Scott Wood, John V Pearson, Sunil R Lakhani, Nicola Waddell, Peter T Simpson, Katia Nones
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often the only source of tumor tissue from patients with advanced, inoperable lung cancer. EBUS-TBNA aspirates are used for the diagnosis, staging, and genomic testing to inform therapy options. Here we extracted DNA and RNA from 220 EBUS-TBNA aspirates to evaluate their suitability for whole genome (WGS), whole exome (WES), and comprehensive panel sequencing. For a subset of 40 cases, the same nucleic acid extraction was sequenced using WGS, WES, and the TruSight Oncology 500 assay...
February 15, 2024: Cancers
https://read.qxmd.com/read/38380940/regional-practice-variation-and-outcomes-in-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-starrt-aki-trial-a-post-hoc-secondary-analysis
#10
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
https://read.qxmd.com/read/38370846/structural-brain-abnormalities-and-aggressive-behaviour-in-schizophrenia-mega-analysis-of-data-from-2095-patients-and-2861-healthy-controls-via-the-enigma-consortium
#11
Jelle Lamsma, Adrian Raine, Seyed M Kia, Wiepke Cahn, Dominic Arold, Nerisa Banaj, Annarita Barone, Katharina Brosch, Rachel Brouwer, Arturo Brunetti, Vince D Calhoun, Qian H Chew, Sunah Choi, Young-Chul Chung, Mariateresa Ciccarelli, Derin Cobia, Sirio Cocozza, Udo Dannlowski, Paola Dazzan, Andrea de Bartolomeis, Marta Di Forti, Alexandre Dumais, Jesse T Edmond, Stefan Ehrlich, Ulrika Evermann, Kira Flinkenflügel, Foivos Georgiadis, David C Glahn, Janik Goltermann, Melissa J Green, Dominik Grotegerd, Amalia Guerrero-Pedraza, Minji Ha, Elliot L Hong, Hilleke Hulshoff Pol, Felice Iasevoli, Stefan Kaiser, Vasily Kaleda, Andriana Karuk, Minah Kim, Tilo Kircher, Matthias Kirschner, Peter Kochunov, Jun Soo Kwon, Irina Lebedeva, Rebekka Lencer, Tiago R Marques, Susanne Meinert, Robin Murray, Igor Nenadić, Dana Nguyen, Godfrey Pearlson, Fabrizio Piras, Edith Pomarol-Clotet, Giuseppe Pontillo, Stéphane Potvin, Adrian Preda, Yann Quidé, Amanda Rodrigue, Kelly Rootes-Murdy, Raymond Salvador, Antonin Skoch, Kang Sim, Gianfranco Spalletta, Filip Spaniel, Frederike Stein, Florian Thomas-Odenthal, Andràs Tikàsz, David Tomecek, Alexander Tomyshev, Mario Tranfa, Uyanga Tsogt, Jessica A Turner, Theo G M van Erp, Neeltje E M van Haren, Jim van Os, Daniela Vecchio, Lei Wang, Adrian Wroblewski, Thomas Nickl-Jockschat
BACKGROUND: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. METHODS: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted and diffusion-weighted magnetic resonance imaging scans in a total of 2095 patients with schizophrenia and 2861 healthy controls...
February 5, 2024: medRxiv
https://read.qxmd.com/read/38336840/connectome-architecture-shapes-large-scale-cortical-alterations-in-schizophrenia-a-worldwide-enigma-study
#12
JOURNAL ARTICLE
Foivos Georgiadis, Sara Larivière, David Glahn, L Elliot Hong, Peter Kochunov, Bryan Mowry, Carmel Loughland, Christos Pantelis, Frans A Henskens, Melissa J Green, Murray J Cairns, Patricia T Michie, Paul E Rasser, Stanley Catts, Paul Tooney, Rodney J Scott, Ulrich Schall, Vaughan Carr, Yann Quidé, Axel Krug, Frederike Stein, Igor Nenadić, Katharina Brosch, Tilo Kircher, Raquel Gur, Ruben Gur, Theodore D Satterthwaite, Andriana Karuk, Edith Pomarol-Clotet, Joaquim Radua, Paola Fuentes-Claramonte, Raymond Salvador, Gianfranco Spalletta, Aristotle Voineskos, Kang Sim, Benedicto Crespo-Facorro, Diana Tordesillas Gutiérrez, Stefan Ehrlich, Nicolas Crossley, Dominik Grotegerd, Jonathan Repple, Rebekka Lencer, Udo Dannlowski, Vince Calhoun, Kelly Rootes-Murdy, Caroline Demro, Ian S Ramsay, Scott R Sponheim, Andre Schmidt, Stefan Borgwardt, Alexander Tomyshev, Irina Lebedeva, Cyril Höschl, Filip Spaniel, Adrian Preda, Dana Nguyen, Anne Uhlmann, Dan J Stein, Fleur Howells, Henk S Temmingh, Ana M Diaz Zuluaga, Carlos López Jaramillo, Felice Iasevoli, Ellen Ji, Stephanie Homan, Wolfgang Omlor, Philipp Homan, Stefan Kaiser, Erich Seifritz, Bratislav Misic, Sofie L Valk, Paul Thompson, Theo G M van Erp, Jessica A Turner, Boris Bernhardt, Matthias Kirschner
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations...
February 9, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38331778/strategies-to-improve-care-for-older-adults-who-present-to-the-emergency-department-a-systematic-review
#13
JOURNAL ARTICLE
Luke Testa, Lieke Richardson, Colleen Cheek, Theresa Hensel, Elizabeth Austin, Mariam Safi, Natália Ransolin, Ann Carrigan, Janet Long, Karen Hutchinson, Magali Goirand, Mia Bierbaum, Felicity Bleckly, Peter Hibbert, Kate Churruca, Robyn Clay-Williams
BACKGROUND: The aim of this systematic review was to examine the relationship between strategies to improve care delivery for older adults in ED and evaluation measures of patient outcomes, patient experience, staff experience, and system performance. METHODS: A systematic review of English language studies published since inception to December 2022, available from CINAHL, Embase, Medline, and Scopus was conducted. Studies were reviewed by pairs of independent reviewers and included if they met the following criteria: participant mean age of ≥ 65 years; ED setting or directly influenced provision of care in the ED; reported on improvement interventions and strategies; reported patient outcomes, patient experience, staff experience, or system performance...
February 8, 2024: BMC Health Services Research
https://read.qxmd.com/read/38251532/stratification-of-biological-therapies-by-pathobiology-in-biologic-naive-patients-with-rheumatoid-arthritis-strap-and-strap-eu-two-parallel-open-label-biopsy-driven-randomised-trials
#14
RANDOMIZED CONTROLLED TRIAL
Felice Rivellese, Alessandra Nerviani, Giovanni Giorli, Louise Warren, Edyta Jaworska, Michele Bombardieri, Myles J Lewis, Frances Humby, Arthur G Pratt, Andrew Filer, Nagui Gendi, Alberto Cauli, Ernest Choy, Iain McInnes, Patrick Durez, Christopher J Edwards, Maya H Buch, Elisa Gremese, Peter C Taylor, Nora Ng, Juan D Cañete, Sabrina Raizada, Neil D McKay, Deepak Jadon, Pier Paolo Sainaghi, Richard Stratton, Michael R Ehrenstein, Pauline Ho, Joaquim P Pereira, Bhaskar Dasgupta, Claire Gorman, James Galloway, Hector Chinoy, Désirée van der Heijde, Peter Sasieni, Anne Barton, Costantino Pitzalis
BACKGROUND: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare the response to rituximab, etanercept, and tocilizumab in biologic-naive patients with rheumatoid arthritis stratified for synovial B cell status. METHODS: STRAP and STRAP-EU were two parallel, open-label, biopsy-driven, stratified, randomised, phase 3 trials done across 26 university centres in the UK and Europe...
November 2023: Lancet Rheumatology
https://read.qxmd.com/read/38233247/standards-for-the-care-of-people-with-cystic-fibrosis-cf-recognising-and-addressing-cf-health-issues
#15
JOURNAL ARTICLE
Pierre-Régis Burgel, Kevin W Southern, Charlotte Addy, Alberto Battezzati, Claire Berry, Jean-Philippe Bouchara, Edwin Brokaar, Whitney Brown, Pilar Azevedo, Isabelle Durieu, Miquel Ekkelenkamp, Felicity Finlayson, Julian Forton, Johanna Gardecki, Pavla Hodkova, Gina Hong, Jacqueline Lowdon, Su Madge, Clémence Martin, Edward McKone, Anne Munck, Chee Y Ooi, Lucy Perrem, Amanda Piper, Andrew Prayle, Felix Ratjen, Margaret Rosenfeld, Don B Sanders, Carsten Schwarz, Giovanni Taccetti, Claire Wainwright, Natalie E West, Michael Wilschanski, Amanda Bevan, Carlo Castellani, Pavel Drevinek, Silvia Gartner, Andrea Gramegna, Elise Lammertyn, Eddie Edwina C Landau, Barry J Plant, Alan R Smyth, Silke van Koningsbruggen-Rietschel, Peter G Middleton
This is the third in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF. This paper focuses on recognising and addressing CF health issues. The guidance was produced with wide stakeholder engagement, including people from the CF community, using an evidence-based framework. Authors contributed sections, and summary statements which were reviewed by a Delphi consultation. Monitoring and treating airway infection, inflammation and pulmonary exacerbations remains important, despite the widespread availability of CFTR modulators and their accompanying health improvements...
January 16, 2024: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/38221827/the-clinical-and-genetic-landscape-of-developmental-and-epileptic-encephalopathies-in-egyptian-children
#16
JOURNAL ARTICLE
Nour Elkhateeb, Mahmoud Y Issa, Hasnaa M Elbendary, Walaa Elnaggar, Areef Ramadan, Karima Rafat, Mona Kamel, Sherif F Abdel-Ghafar, Fawzia Amer, Hebatallah M Hassaan, Roberta Trunzo, Catarina Pereira, Mohamed S Abdel-Hamid, Felice D'Arco, Peter Bauer, Aida M Bertoli-Avella, Marian Girgis, Joseph G Gleeson, Maha S Zaki, Laila Selim
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of epilepsies characterized by early-onset, refractory seizures associated with developmental regression or impairment, with a heterogeneous genetic landscape including genes implicated in various pathways and mechanisms. We retrospectively studied the clinical and genetic data of patients with genetic DEE who presented at two tertiary centers in Egypt over a 10-year period. Exome sequencing was used for genetic testing. We report 74 patients from 63 unrelated Egyptian families, with a high rate of consanguinity (58%)...
January 14, 2024: Clinical Genetics
https://read.qxmd.com/read/38134401/delayed-mucosal-anti-viral-responses-despite-robust-peripheral-inflammation-in-fatal-covid-19
#17
JOURNAL ARTICLE
Jasmin K Sidhu, Matthew K Siggins, Felicity Liew, Clark D Russell, Ashley S S Uruchurtu, Christopher Davis, Lance Turtle, Shona C Moore, Hayley E Hardwick, Wilna Oosthuyzen, Emma C Thomson, Malcolm G Semple, J Kenneth Baillie, Peter J M Openshaw, Ryan S Thwaites
BACKGROUND: While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and relate these to disease progression and peripheral inflammation. METHODS: We measured 35 cytokines and chemokines in nasal samples from 274 patients hospitalised with COVID-19...
December 22, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/38117126/temporal-integration-of-tone-signals-by-a-killer-whale-orcinus-orca
#18
JOURNAL ARTICLE
Brian K Branstetter, Kayla Nease, Alyssa W Accomando, Jennifer Davenport, Michael Felice, Ken Peters, Todd Robeck
A psychophysical procedure was used to measure pure-tone detection thresholds for a killer whale (Orcinus orca) as a function of both signal frequency and signal duration. Frequencies ranged between 1 and 100 kHz and signal durations ranged from 50 μs to 2 s, depending on the frequency. Detection thresholds decreased with an increase in signal duration up to a critical duration, which represents the auditory integration time. Integration times ranged from 4 ms at 100 kHz and increased up to 241 ms at 1 kHz...
December 1, 2023: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38093007/a-synthesis-of-evidence-for-policy-from-behavioural-science-during-covid-19
#19
JOURNAL ARTICLE
Kai Ruggeri, Friederike Stock, S Alexander Haslam, Valerio Capraro, Paulo Boggio, Naomi Ellemers, Aleksandra Cichocka, Karen M Douglas, David G Rand, Sander van der Linden, Mina Cikara, Eli J Finkel, James N Druckman, Michael J A Wohl, Richard E Petty, Joshua A Tucker, Azim Shariff, Michele Gelfand, Dominic Packer, Jolanda Jetten, Paul A M Van Lange, Gordon Pennycook, Ellen Peters, Katherine Baicker, Alia Crum, Kim A Weeden, Lucy Napper, Nassim Tabri, Jamil Zaki, Linda Skitka, Shinobu Kitayama, Dean Mobbs, Cass R Sunstein, Sarah Ashcroft-Jones, Anna Louise Todsen, Ali Hajian, Sanne Verra, Vanessa Buehler, Maja Friedemann, Marlene Hecht, Rayyan S Mobarak, Ralitsa Karakasheva, Markus R Tünte, Siu Kit Yeung, R Shayna Rosenbaum, Žan Lep, Yuki Yamada, Sa-Kiera Tiarra Jolynn Hudson, Lucía Macchia, Irina Soboleva, Eugen Dimant, Sandra J Geiger, Hannes Jarke, Tobias Wingen, Jana B Berkessel, Silvana Mareva, Lucy McGill, Francesca Papa, Bojana Većkalov, Zeina Afif, Eike K Buabang, Marna Landman, Felice Tavera, Jack L Andrews, Aslı Bursalıoğlu, Zorana Zupan, Lisa Wagner, Joaquín Navajas, Marek Vranka, David Kasdan, Patricia Chen, Kathleen R Hudson, Lindsay M Novak, Paul Teas, Nikolay R Rachev, Matteo M Galizzi, Katherine L Milkman, Marija Petrović, Jay J Van Bavel, Robb Willer
Scientific evidence regularly guides policy decisions1 , with behavioural science increasingly part of this process2 . In April 2020, an influential paper3 proposed 19 policy recommendations ('claims') detailing how evidence from behavioural science could contribute to efforts to reduce impacts and end the COVID-19 pandemic. Here we assess 747 pandemic-related research articles that empirically investigated those claims. We report the scale of evidence and whether evidence supports them to indicate applicability for policymaking...
December 13, 2023: Nature
https://read.qxmd.com/read/37984243/impact-of-liver-cirrhosis-severity-of-cirrhosis-and-portal-hypertension-on-the-difficulty-of-laparoscopic-and-robotic-minor-liver-resections-for-primary-liver-malignancies-in-the-anterolateral-segments
#20
JOURNAL ARTICLE
Junhao Zheng, Xiao Liang, Andrew G R Wu, Tousif Kabir, Olivier Scatton, Chetana Lim, Kiyoshi Hasegawa, Jasper P Sijberden, Davit L Aghayan, Tiing Foong Siow, Safi Dokmak, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqiu Yin, Zewei Chen, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Salvatore Gruttadauria, Alejandro Mejia, James O Park, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Eric C H Lai, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Federica Cipriani, Olivier Soubrane, Wanguang Zhang, Go Wakabayashi, Roberto I Troisi, Tan-To Cheung, Yutaro Kato, Atsushi Sugioka, Tran Cong Duy Long, Rong Liu, Bjørn Edwin, David Fuks, Mohammad Abu Hilal, Kuo-Hsin Chen, Luca Aldrighetti, Ho-Seong Han, Brian K P Goh
INTRODUCTION: We performed this study in order to investigate the impact of liver cirrhosis (LC) on the difficulty of minimally invasive liver resection (MILR), focusing on minor resections in anterolateral (AL) segments for primary liver malignancies. METHODS: This was an international multicenter retrospective study of 3675 patients who underwent MILR across 60 centers from 2004 to 2021. RESULTS: 1312 (35.7%) patients had no cirrhosis, 2118 (57...
November 8, 2023: European Journal of Surgical Oncology
keyword
keyword
70630
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.