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https://www.readbyqxmd.com/read/28101606/practice-guidelines-as-implementation-science-the-journal-editors-perspective
#1
EDITORIAL
Timothy G Buchman, Elie Azoulay
No abstract text is available yet for this article.
January 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28099221/practice-guidelines-as-implementation-science-the-journal-editors-perspective
#2
Timothy G Buchman, Elie Azoulay
No abstract text is available yet for this article.
January 17, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28098625/innovative-interdisciplinary-strategies-to-address-the-intensivist-shortage
#3
Timothy G Buchman, Craig M Coopersmith, Heather W Meissen, W Robert Grabenkort, Vishal Bakshi, Cheryl A Hiddleson, Sara R Gregg
No abstract text is available yet for this article.
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28078889/quantification-of-free-polyelectrolytes-present-in-colloidal-suspension-revealing-a-source-of-toxic-responses-for-polyelectrolyte-wrapped-gold-nanoparticles
#4
Tian A Qiu, Marco D Torelli, Ariane M Vartanian, Nathan B Rackstraw, Joseph T Buchman, Lisa M Jacob, Catherine J Murphy, Robert J Hamers, Christy L Haynes
Polyelectrolyte (PE) wrapping of colloidal nanoparticles (NPs) is a standard method to control NP surface chemistry and charge. Because excess polyelectrolytes are usually employed in the surface modification process, it is critical to evaluate different purification strategies to obtain a clean final product and thus avoid ambiguities in the source of effects on biological systems. In this work, 4 nm diameter gold nanoparticles (AuNPs) were wrapped with 15 kDa poly(allylamine hydrochloride) (PAH), and three purification strategies were applied: (a) diafiltration or either (b) one round or (c) two rounds of centrifugation...
January 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28078707/commentary-on-mcauley-et-al-2017-naloxone-programs-must-reduce-marginalization-and-improve-access-to-comprehensive-emergency-care
#5
Aaron M Orkin, Daniel Z Buchman
No abstract text is available yet for this article.
February 2017: Addiction
https://www.readbyqxmd.com/read/28077804/the-complex-genetics-of-gait-speed-genome-wide-meta-analysis-approach
#6
Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L Lunetta, Jennifer A Smith, John D Eicher, Rotem Vered, Joris Deelen, Alice M Arnold, Aron S Buchman, Toshiko Tanaka, Jessica D Faul, Maria Nethander, Myriam Fornage, Hieab H Adams, Amy M Matteini, Michele L Callisaya, Albert V Smith, Lei Yu, Philip L De Jager, Denis A Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J Launer, Davis S Knopman, Neeta Parimi, Stephen T Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P Mooijaart, David C Liewald, Jeanine J Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J Verlinden, Dan Mellström, Jos N van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J Tranah, Andre G Uitterlinden, David R Weir, Wei Zhao, John M Starr, Andrew D Johnson, M Arfan Ikram, David A Bennett, Steven R Cummings, Ian J Deary, Tamara B Harris, Sharon L R Kardia, Thomas H Mosley, Velandai K Srikanth, Beverly G Windham, Ann B Newman, Jeremy D Walston, Gail Davies, Daniel S Evans, Eline P Slagboom, Luigi Ferrucci, Douglas P Kiel, Joanne M Murabito, Gil Atzmon
Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues...
January 10, 2017: Aging
https://www.readbyqxmd.com/read/28045810/the-protruding-premaxilla-is-our-current-approach-the-right-answer
#7
Katelyn G Bennett, Heather M Hendricks, Todd E Thurston, Steven J Kasten, Christian J Vercler, Steven R Buchman
BACKGROUND: In bilateral cleft patients, surgeons usually attempt to move the premaxillary segment posteriorly. These patients almost always develop maxillary hypoplasia, rendering our current algorithms questionable. The authors sought to determine if the lateral segments are in an appropriate position to serve as a target for movement of the premaxilla. METHODS: Bilateral cleft lip and palate patients treated at the University of Michigan from 1997 to 2015 were reviewed...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28035346/diet-induced-weight-loss-is-sufficient-to-reduce-senescent-cell-number-in-white-adipose-tissue-of-weight-cycled-mice
#8
Edward O List, Elizabeth Jensen, Jesse Kowalski, Mathew Buchman, Darlene E Berryman, John J Kopchick
Previously, our laboratory reported that weight-cycled mice outlive their obese counterparts. To gain a better mechanistic understanding of these results, we evaluated cellular senescence in white adipose tissue (WAT) of lean, obese, and weight cycled mice. Our results show that at the end of a 28 day weight loss cycle cellular senescence is significantly reduced in multiple WAT depots compared to obese mice, which also corresponds to a reduction in circulating activin A (a marker of senescence). These findings suggest that a previously undescribed benefit to weight loss may be a reduction of cellular senescence in WAT...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28031006/catheter-salvage-during-infections-in-patients-receiving-home-parenteral-nutrition
#9
Alan L Buchman
No abstract text is available yet for this article.
January 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28009754/public-solicitation-of-anonymous-organ-donors-a-position-paper-by-the-canadian-society-of-transplantation
#10
Marie-Chantal Fortin, Daniel Buchman, Linda Wright, Jennifer Chandler, Sean Delaney, Todd Fairhead, Rob Gallaher, David Grant, Rebecca Greenberg, David Hartell, Sandra Holdsworth, David Landsberg, Steven Paraskevas, Lee Anne Tibbles, Kimberly Young, Lori West, Atul Humar
No abstract text is available yet for this article.
January 2017: Transplantation
https://www.readbyqxmd.com/read/28005251/investigating-trust-expertise-and-epistemic-injustice-in-chronic-pain
#11
Daniel Z Buchman, Anita Ho, Daniel S Goldberg
Trust is central to the therapeutic relationship, but the epistemic asymmetries between the expert healthcare provider and the patient make the patient, the trustor, vulnerable to the provider, the trustee. The narratives of pain sufferers provide helpful insights into the experience of pain at the juncture of trust, expert knowledge, and the therapeutic relationship. While stories of pain sufferers having their testimonies dismissed are well documented, pain sufferers continue to experience their testimonies as being epistemically downgraded...
December 22, 2016: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/27993133/synthesis-and-functionalization-of-protease-activated-nanoparticles-with-tissue-plasminogen-activator-peptides-as-targeting-moiety-and-diagnostic-tool-for-pancreatic-cancer
#12
Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker, Klaus Felix
BACKGROUND: Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed delivery with a suitable target-biomarker to detect early pancreatic ductal adenocarcinoma (PDAC). Promising targets are galectins (Gal), due to their strong expression in and on PDAC-cells and occurrence at early stages in cancer precursor lesions, but not in adjacent normal tissues...
December 19, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27927762/urinary-incontinence-incident-parkinsonism-and-parkinson-s-disease-pathology-in-older-adults
#13
Noa M Buchman, Sue E Leurgans, Raj J Shah, Veronique VanderHorst, Robert S Wilson, Yaacov G Bachner, David Tanne, Julie A Schneider, David A Bennett, Aron S Buchman
OBJECTIVE: To test the hypothesis that urinary incontinence (UI) is associated with incident parkinsonism in older adults. METHODS: We used data from 2,617 older persons without dementia. Assessment included baseline self-report UI and annual structured exam which assessed parkinsonian signs, motor performances, cognitive function, and self-report disabilities. We used a series of Cox proportional hazards models to examine the association of UI with parkinsonism and adverse health outcomes and a mixed-effect model to examine the association of UI with the annual rate of cognitive decline...
December 7, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27916375/the-role-of-the-adaptive-immune-system-in-burn-induced-heterotopic-ossification-and-mesenchymal-cell-osteogenic-differentiation
#14
Kavitha Ranganathan, Shailesh Agarwal, David Cholok, Shawn Loder, Jonathan Li, Hsiao Hsin Sung Hsieh, Stewart C Wang, Steven R Buchman, Benjamin Levi
BACKGROUND: Heterotopic ossification (HO) is the pathologic process of extraskeletal bone formation. Although the exact etiology remains unknown, inflammation appears to catalyze disease progression. The goal of this study is to determine the impact of the adaptive immune system on HO. METHODS: HO was induced in 8-wk-old control C57BL/6 and immunocompromised Rag1tm1Mom (Rag1 KO) male mice deficient in B- and T-lymphocytes via combined Achilles tenotomy and burn injury...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27851067/1431-organ-failure-data-over-time-in-the-critically-ill-at-what-cost-and-to-what-benefit
#15
Andre Holder, David Murphy, Elizabeth Overton, Peter Lyu, Greg Martin, Timothy Buchman
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27779806/role-of-parathyroid-hormone-in-regeneration-of-irradiated-bone-in-a-murine-model-of-mandibular-distraction-osteogenesis
#16
Stephen Y Kang, Sagar S Deshpande, Alexander R Zheutlin, Alexis Donneys, Jose J Rodriguez, Noah S Nelson, Peter A Felice, Douglas B Chepeha, Steven R Buchman
BACKGROUND: The purpose of this study was to measure the histologic and histomorphometric effects of parathyroid hormone (PTH) treatment on irradiated bone undergoing distraction osteogenesis (DO). METHODS: Thirty-four rats were divided into 3 groups. The control group underwent DO and the radiation control group underwent radiotherapy (RT) before DO. The PTH group underwent RT and received PTH during DO. Quantitative histology and histomorphometry were performed...
October 25, 2016: Head & Neck
https://www.readbyqxmd.com/read/27773979/self-reported-sleep-in-older-african-americans-and-white-americans
#17
Arlener D Turner, Andrew S Lim, Sue E Leurgans, David A Bennett, Aron S Buchman, Lisa L Barnes
OBJECTIVE: Assess the relationship of self-reported sleep quality and possible sleep disorders with disability in a racially diverse sample of community-dwelling older adults. METHODS: Participants included 943 non-demented older African Americans (n=452) and Whites (n=491) from two cohort studies, the Minority Aging Research Study (MARS) and the Rush Memory and Aging Project (MAP). Participants completed a 32-item questionnaire assessing sleep quality and the possible presence of three sleep disorders (sleep apnea, restless leg syndrome [RLS] and REM behavior disorder [RBD])...
October 20, 2016: Ethnicity & Disease
https://www.readbyqxmd.com/read/27755078/a-glimpse-of-precision-medicine-for-multiple-organ-dysfunction-syndrome
#18
Timothy G Buchman
No abstract text is available yet for this article.
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27749750/the-compound-action-potential-in-subjects-receiving-a-cochlear-implant
#19
William C Scott, Christopher K Giardina, Andrew K Pappa, Tatyana E Fontenot, Meredith L Anderson, Margaret T Dillon, Kevin D Brown, Harold C Pillsbury, Oliver F Adunka, Craig A Buchman, Douglas C Fitzpatrick
HYPOTHESIS: The compound action potential (CAP) is a purely neural component of the cochlea's response to sound, and may provide information regarding the existing neural substrate in cochlear implant (CI) subjects that can help account for variance in speech perception outcomes. BACKGROUND: Measurement of the "total response" (TR), or sum of the magnitudes of spectral components in the ongoing responses to tone bursts across frequencies, has been shown to account for 40 to 50% of variance in speech perception outcomes...
December 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27737990/la-responsabilit%C3%A3-sociale-au-macroniveau-concr%C3%A3-tisation-%C3%A3-l%C3%A2-%C3%A3-chelle-globale
#20
Ryan Meili, Sandy Buchman, Ritika Goel, Robert Woollard
No abstract text is available yet for this article.
October 2016: Canadian Family Physician Médecin de Famille Canadien
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