keyword
MENU ▼
Read by QxMD icon Read
search

Buchman

keyword
https://www.readbyqxmd.com/read/29757018/a-current-structural-perspective-on-pxr-and-car-in-drug-metabolism
#1
Cameron D Buchman, Sergio C Chai, Taosheng Chen
Pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that play major roles in the expression of various drug metabolism enzymes and are known for their ligand promiscuity. As with other nuclear receptors, PXR and CAR are each composed of a ligand-binding domain (LBD) and a DNA-binding domain (DBD) connected by a hinge region. Areas covered: This review focuses on the information obtained over the last 15+ years from X-ray crystallography studies of the structure of PXR and CAR...
May 14, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29752306/-apoe-%C3%AE%C2%B52%C3%AE%C2%B54-genotype-incident-ad-and-mci-cognitive-decline-and-ad-pathology-in-older-adults
#2
Shahram Oveisgharan, Aron S Buchman, Lei Yu, Jose Farfel, Vladimir Hachinski, Chris Gaiteri, Philip L De Jager, Julie A Schneider, David A Bennett
OBJECTIVE: To examine the association of the APOE ε2ε4 genotype with incident Alzheimer disease (AD), mild cognitive impairment (MCI), cognitive decline, and AD pathology in older adults. METHODS: We used data from 2,151 older adults of European ancestry who were free of dementia at baseline and underwent structured annual clinical evaluation in a longitudinal study for incident AD and MCI, and cognitive decline. Postmortem examination in decedents documented pathologic AD and quantified β-amyloid and neurofibrillary tangles...
May 11, 2018: Neurology
https://www.readbyqxmd.com/read/29735035/transplantation-of-abdominal-organs
#3
EDITORIAL
Alan L Buchman
No abstract text is available yet for this article.
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29735027/intestinal-failure-and-rehabilitation
#4
REVIEW
Alan L Buchman
The rendering of proper care for the patient with intestinal failure requires the provider to have a functional understanding of digestion and absorption, nutrient requirements, and intestinal adaptation. Inherent in those concepts is that not only is nutritional absorption compromised, but medication absorption is as well. The principles of the management of home parenteral nutrition must be mastered and then proper and controlled weaning of parenteral nutrition may be commenced by use of dietary and pharmacologic means with appropriate clinical outcome measures followed...
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29733807/fractal-regulation-and-incident-alzheimer-s-disease-in-elderly-individuals
#5
Peng Li, Lei Yu, Andrew S P Lim, Aron S Buchman, Frank A J L Scheer, Steven A Shea, Julie A Schneider, David A Bennett, Kun Hu
INTRODUCTION: Healthy physiological systems exhibit fractal regulation (FR), generating similar fluctuation patterns in physiological outputs across different time scales. FR in motor activity is degraded in dementia, and the degradation correlates to cognitive decline. We tested whether degraded FR predicts Alzheimer's disease dementia. METHODS: FR in motor activity was assessed in 1097 nondemented older adults at baseline. Cognition was assessed annually for up to 11 years...
May 4, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29732951/effects-of-cochlear-implantation-on-binaural-hearing-in-adults-with-unilateral-hearing-loss
#6
Emily Buss, Margaret T Dillon, Meredith A Rooth, English R King, Ellen J Deres, Craig A Buchman, Harold C Pillsbury, Kevin D Brown
A FDA clinical trial was carried out to evaluate the potential benefit of cochlear implant (CI) use for adults with unilateral moderate-to-profound sensorineural hearing loss. Subjects were 20 adults with moderate-to-profound unilateral sensorineural hearing loss and normal or near-normal hearing on the other side. A MED-EL standard electrode was implanted in the impaired ear. Outcome measures included: (a) sound localization on the horizontal plane (11 positions, -90° to 90°), (b) word recognition in quiet with the CI alone, and (c) masked sentence recognition with the target at 0° and the masker at -90°, 0°, or 90°...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29695600/brain-pathology-is-related-to-total-daily-physical-activity-in-older-adults
#7
Aron S Buchman, Robert J Dawe, Lei Yu, Andrew Lim, Robert S Wilson, Julie A Schneider, David A Bennett
OBJECTIVE: To test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults. METHODS: We studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with actigraphy (Actical; Philips Healthcare, Bend, OR). Multiple regression analyses controlling for age and sex were used to examine the relation of brain indexes to total daily physical activity and other clinical covariates proximate to death...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29666236/synthetically-engineered-medea-gene-drive-system-in-the-worldwide-crop-pest-drosophila-suzukii
#8
Anna Buchman, John M Marshall, Dennis Ostrovski, Ting Yang, Omar S Akbari
Synthetic gene drive systems possess enormous potential to replace, alter, or suppress wild populations of significant disease vectors and crop pests; however, their utility in diverse populations remains to be demonstrated. Here, we report the creation of a synthetic Medea gene drive system in a major worldwide crop pest, Drosophila suzukii We demonstrate that this drive system, based on an engineered maternal "toxin" coupled with a linked embryonic "antidote," is capable of biasing Mendelian inheritance rates with up to 100% efficiency...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29659683/review-of-100-fruit-juice-and-chronic-health-conditions-implications-for-sugar-sweetened-beverage-policy
#9
Brandon J Auerbach, Sepideh Dibey, Petra Vallila-Buchman, Mario Kratz, James Krieger
Whether or not drinking 100% fruit juice causes poor health is controversial. Although 100% fruit juice may contain as much sugar as regular soda, it provides needed nutrients to Americans' diets. We systematically reviewed the current evidence of the association of 100% fruit juice consumption and chronic health conditions in children and adults. We focused on data from systematic reviews and meta-analyses about cardiometabolic health outcomes, liver disease, and caries. Aside from increased risk of tooth decay in children and small amounts of weight gain in young children and adults, there is no conclusive evidence that consumption of 100% fruit juice has adverse health effects...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29624586/hidden-danger-unexpected-scenario-in-the-vector-parasite-dynamics-of-leishmaniases-in-the-brazil-side-of-triple-border-argentina-brazil-and-paraguay
#10
Vanete Thomaz-Soccol, André Luiz Gonçalves, Claudio Adriano Piechnik, Rafael Antunes Baggio, Walter Antônio Boeger, Themis Leão Buchman, Mario Sergio Michaliszyn, Demilson Rodrigues Dos Santos, Adão Celestino, José Aquino, André de Souza Leandro, Otacílio Lopes de Souza da Paz, Marcelo Limont, Alceu Bisetto, Jeffrey Jon Shaw, Zaida Estela Yadon, Oscar Daniel Salomon
Every year about 3 million tourists from around the world visit Brazil, Argentina and Paraguay´s triple border region where the Iguaçu Falls are located. Unfortunately, in recent years an increasing number of autochthonous canine and human visceral leishmaniosis (VL) cases have been reported. The parasite is Leishmania (Leishmania) infantum and it is transmitted by sand flies (Phlebotominae). To assess the risk factors favorable for the establishment and spread of potential vectors the Centers for Disease Control and Prevention light trap (CDC-light trap) collections were made in the Foz do Iguaçu (FI) and Santa Terezinha de Itaipu (STI) townships and along two transects between them...
April 6, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29608276/engineered-reciprocal-chromosome-translocations-drive-high-threshold-reversible-population-replacement-in-drosophila
#11
Anna Buchman, Tobin Ivy, John Marshall, Omar S Akbari, Bruce A Hay
Replacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions using gene drive provides a self-perpetuating method of disease prevention. Mechanisms that require the gene drive element and linked cargo to exceed a high threshold frequency in order for spread to occur are attractive because they offer several points of control: they bring about local, but not global population replacement; and transgenes can be eliminated by reintroducing wildtypes into the population so as to drive the frequency of transgenes below the threshold frequency required for drive...
April 2, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29570381/sociodemographic-predictors-of-missed-appointments-among-patients-with-cleft-lip-and-palate
#12
Jeremy V Lynn, Kavitha Ranganathan, Matthew H Bageris, Tami Hart-Johnson, Steven R Buchman, R Alexander Blackwood
OBJECTIVE: To identify disparities in compliance of and care for patients with cleft lip and/or palate (CL/P) by determining the impact of sociodemographic variables on the rate of missed appointments and Child Protective Services (CPS) involvement. DESIGN: A retrospective, noninterventional quality assessment and quality improvement study were designed. SETTING: This institutional study was performed at the University of Michigan in Ann Arbor, Michigan...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29557283/minimum-reporting-standards-for-adult-cochlear-implantation
#13
Oliver F Adunka, Bruce J Gantz, Camille Dunn, Richard K Gurgel, Craig A Buchman
This article outlines new minimum standards for reporting adult cochlear implant outcomes. These standards have been endorsed by the Implantable Hearing Devices Committee and the Hearing Committee of the American Academy of Otolaryngology-Head and Neck Surgery. The lack of a standardized method for reporting outcomes following cochlear implantation in clinical trials has hampered the ability of investigators to draw comparisons across studies. Variability in data reported in articles and presentation formats inhibits meta-analyses, making it impossible to accumulate the large patient cohorts needed for statistically significant inference...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29556791/novel-formulation-strategy-to-improve-the-feasibility-of-amifostine-administration
#14
Kavitha Ranganathan, Eric Simon, Jeremy Lynn, Alicia Snider, Yu Zhang, Noah Nelson, Alexis Donneys, Jose Rodriguez, Lauren Buchman, Dawn Reyna, Elke Lipka, Steven R Buchman
PURPOSE: Amifostine (AMF), a radioprotectant, is FDA-approved for intravenous administration in cancer patients receiving radiation therapy (XRT). Unfortunately, it remains clinically underutilized due to adverse side effects. The purpose of this study is to define the pharmacokinetic profile of an oral AMF formulation potentially capable of reducing side effects and increasing clinical feasibility. METHODS: Calvarial osteoblasts were radiated under three conditions: no drug, AMF, and WR-1065 (active metabolite)...
March 19, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29554036/response-changes-during-insertion-of-a-cochlear-implant-using-extracochlear-electrocochleography
#15
Christopher K Giardina, Tatyana E Khan, Stephen H Pulver, Oliver F Adunka, Craig A Buchman, Kevin D Brown, Harold C Pillsbury, Douglas C Fitzpatrick
OBJECTIVES: Electrocochleography is increasingly being utilized as an intraoperative monitor of cochlear function during cochlear implantation (CI). Intracochlear recordings from the advancing electrode can be obtained through the device by on-board capabilities. However, such recordings may not be ideal as a monitor because the recording electrode moves in relation to the neural and hair cell generators producing the responses. The purposes of this study were to compare two extracochlear recording locations in terms of signal strength and feasibility as intraoperative monitoring sites and to characterize changes in cochlear physiology during CI insertion...
March 16, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29437520/timing-of-furlow-palatoplasty-for-patients-with-submucous-cleft-palate
#16
Russell E Ettinger, Theodore A Kung, Natalie Wombacher, Mary Berger, M Haskell Newman, Steven R Buchman, Steven J Kasten
BACKGROUND: Submucous cleft palate (SMCP) is the most common form of cleft involving the posterior palate, resulting in variable degrees of velar dysfunction and speech disturbance. Although early surgical intervention is indicated for patients with true cleft palate, the indications for palatoplasty and timing of surgical intervention for patients with SMCP remain controversial. METHODS: Twenty-nine patients with SMCP were retrospectively reviewed. Patients treated with Furlow palatoplasty were dichotomized based on patient age at the time of surgical correction into early speech development and late speech development...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29420861/do-subjects-with-minimal-motor-features-have-prodromal-parkinson-disease
#17
Yaping Chu, Aron S Buchman, C Warren Olanow, Jeffrey H Kordower
OBJECTIVE: Understanding the pathological changes underlying mild motor features of the eldery and defining a patient population with prodromal Parkinson disease (PD) are of great clinical importance. It remains unclear, however, how to accurately and specifically diagnose prodromal PD. We examined whether older adults with minimal parkinsonian motor features have nigrostriatal degeneration and α-synuclein pathology consistent with prodromal PD. METHODS: Brain sections were obtained from older adults with a clinical diagnosis of PD (n = 21) and without a clinical diagnosis of PD (n = 27) who underwent motor examination proximate to death...
March 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29413027/nutrition-and-disease
#18
EDITORIAL
Alan L Buchman
No abstract text is available yet for this article.
March 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29412179/high-frequency-spectral-ultrasound-imaging-susi-visualizes-early-post-traumatic-heterotopic-ossification-ho-in-a-mouse-model
#19
Kavitha Ranganathan, Xiaowei Hong, David Cholok, Joe Habbouche, Caitlin Priest, Christopher Breuler, Michael Chung, John Li, Arminder Kaura, Hsiao Hsin Sung Hsieh, Jonathan Butts, Serra Ucer, Ean Schwartz, Steven R Buchman, Jan P Stegemann, Cheri X Deng, Benjamin Levi
PURPOSE: Early treatment of heterotopic ossification (HO) is currently limited by delayed diagnosis due to limited visualization at early time points. In this study, we validate the use of spectral ultrasound imaging (SUSI) in an animal model to detect HO as early as one week after burn tenotomy. METHODS: Concurrent SUSI, micro CT, and histology at 1, 2, 4, and 9weeks post-injury were used to follow the progression of HO after an Achilles tenotomy and 30% total body surface area burn (n=3-5 limbs per time point)...
April 2018: Bone
https://www.readbyqxmd.com/read/29396225/international-consensus-icon-on-assessment-of-oropharyngeal-dysphagia
#20
F Espitalier, A Fanous, J Aviv, S Bassiouny, G Desuter, N Nerurkar, G Postma, L Crevier-Buchman
OBJECTIVE: To present international recommendations regarding the proper evaluation of oropharyngeal dysphagia (OD), both objectively and subjectively (self-evaluation). METHODS: Following a thorough review of the literature, 5 experts in the field from 4 different continents answered separately a questionnaire regarding the work-up of OD. Individual answers were presented and discussed during the world ENT conference that was held in Paris in June 2017. This article will present the recommendations issued from that meeting...
February 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
keyword
keyword
70627
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"