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https://www.readbyqxmd.com/read/28317445/a-sociobiological-extension-of-the-interpersonal-theory-of-suicide
#1
Thomas E Joiner, Jennifer M Buchman-Schmitt, Carol Chu, Melanie A Hom
No abstract text is available yet for this article.
March 2017: Crisis
https://www.readbyqxmd.com/read/28276506/modulation-of-p-eif2%C3%AE-cellular-levels-and-stress-granule-assembly-disassembly-by-trehalose
#2
Pasquale Dimasi, Annamaria Quintiero, Tatyana A Shelkovnikova, Vladimir L Buchman
Stress granules (SGs) are an important component of cellular stress response. Compromised assembly of SGs as well as their premature or delayed disassembly affect physiology and survival of cells under stress or during recovery from stress. Consequently, abnormal turnover of SGs has been implicated in the development of various pathologies, including neurodegeneration. We found that pretreatment of cells with a natural disaccharide trehalose, a known autophagy enhancer, delays SG assembly and facilitates their premature post-stress disassembly...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28243144/a-double-blind-randomized-comparative-study-of-the-use-of-a-combination-of-uridine-triphosphate-trisodium-cytidine-monophosphate-disodium-and-hydroxocobalamin-versus-isolated-treatment-with-hydroxocobalamin-in-patients-presenting-with-compressive-neuralgias
#3
Henrique Goldberg, Marco Antonio Mibielli, Carlos Pereira Nunes, Stephanie Wrobel Goldberg, Luiz Buchman, Spyros Ge Mezitis, Helio Rzetelna, Lisa Oliveira, Mauro Geller, Fernanda Wajnsztajn
CONTEXT: This paper reports on the results of treatment of compressive neuralgia using a combination of nucleotides (uridine triphosphate trisodium [UTP] and cytidine monophosphate disodium [CMP]) and vitamin B12. OBJECTIVES: To assess the safety and efficacy of the combination of nucleotides (UTP and CMP) and vitamin B12 in patients presenting with neuralgia arising from neural compression associated with degenerative orthopedic alterations and trauma, and to compare these effects with isolated administration of vitamin B12...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28242853/author-response-incident-parkinsonism-in-older-adults-without-parkinson-disease
#4
Aron S Buchman, David A Bennett
No abstract text is available yet for this article.
February 28, 2017: Neurology
https://www.readbyqxmd.com/read/28242851/author-response-incident-parkinsonism-in-older-adults-without-parkinson-disease
#5
Aron S Buchman, David A Bennett
No abstract text is available yet for this article.
February 28, 2017: Neurology
https://www.readbyqxmd.com/read/28219011/inhibition-of-the-aldehyde-dehydrogenase-1-2-family-by-psoralen-and-coumarin-derivatives
#6
Cameron D Buchman, Thomas D Hurley
Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD(+)-dependent oxidation of aldehydes to their respective carboxylic acids. In this study, we further characterized the inhibition of four psoralen and coumarin derivatives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes. Compound 2 (Ki = 19 nM) binds within the aldehyde-binding site of the free enzyme species of ALDH2. Thirty-three structural analogs were examined to develop a stronger SAR profile...
March 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28207468/significant-differences-in-the-bone-of-an-isogenic-inbred-versus-nonisogenic-outbred-murine-mandible-a-study-in-rigor-and-reproducibility
#7
Edward G Carey, Sagar S Deshpande, Kevin M Urlaub, Alexander R Zheutlin, Noah S Nelson, Alexis Donneys, Stephen Y Kang, Kathleen K Gallagher, Peter A Felice, Catherine N Tchanque-Fossuo, Steven R Buchman
Inattention to differences between animal strains is a potential cause of irreproducibility of basic science investigations. Accordingly, the authors' laboratory sought to ensure that cross-comparisons of results generated from studies of mandibular physiology utilizing the Sprague Dawley and Lewis rat strains are valid. The authors specifically investigated baseline histomorphometrics, bone mineral density, and biomechanical strength of the unaltered endogenous mandibles of the inbred, isogenic Lewis rat, and the outbred, nonisogenic Sprague Dawley rat to determine if they are indeed equal...
February 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28201847/the-differentiation-of-intestinal-failure-associated-liver-disease-from-nonalcoholic-fatty-liver-and-nonalcoholic-steatohepatitis
#8
Alan L Buchman, Bita V Naini, Bert Spilker
Intestinal failure-associated liver disease (IFALD), formerly known as parenteral nutrition-associated liver disease has often been listed in textbooks as an example of nonalcoholic fatty liver disease (NAFLD). However, the etiology, pathophysiology, epidemiology, histology, and progression differ substantially between the conditions defined as NAFLD and the disease, IFALD. Therefore, IFALD should not be defined or considered as a type or a cause of nonalcoholic fatty liver or nonalcoholic steatohepatitis, but rather as a distinct disease...
February 2017: Seminars in Liver Disease
https://www.readbyqxmd.com/read/28190560/filtering-authentic-sepsis-arising-in-the-icu-using-administrative-codes-coupled-to-a-sirs-screening-protocol
#9
Christopher L Sudduth, Elizabeth C Overton, Peter F Lyu, Ramzy H Rimawi, Timothy G Buchman
PURPOSE: Using administrative codes and minimal physiologic and laboratory data, we sought a high-specificity identification strategy for patients whose sepsis initially appeared during their ICU stay. MATERIALS AND METHODS: We studied all patients discharged from an academic hospital between September 1, 2013 and October 31, 2014. Administrative codes and minimal physiologic and laboratory criteria were used to identify patients at high risk of developing the onset of sepsis in the ICU...
February 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28101606/practice-guidelines-as-implementation-science-the-journal-editors-perspective
#10
EDITORIAL
Timothy G Buchman, Elie Azoulay
No abstract text is available yet for this article.
March 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28099221/practice-guidelines-as-implementation-science-the-journal-editors-perspective
#11
Timothy G Buchman, Elie Azoulay
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28098625/innovative-interdisciplinary-strategies-to-address-the-intensivist-shortage
#12
Timothy G Buchman, Craig M Coopersmith, Heather W Meissen, W Robert Grabenkort, Vishal Bakshi, Cheryl A Hiddleson, Sara R Gregg
No abstract text is available yet for this article.
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28078889/quantification-of-free-polyelectrolytes-present-in-colloidal-suspension-revealing-a-source-of-toxic-responses-for-polyelectrolyte-wrapped-gold-nanoparticles
#13
Tian A Qiu, Marco D Torelli, Ariane M Vartanian, Nathan B Rackstraw, Joseph T Buchman, Lisa M Jacob, Catherine J Murphy, Robert J Hamers, Christy L Haynes
Polyelectrolyte (PE) wrapping of colloidal nanoparticles (NPs) is a standard method to control NP surface chemistry and charge. Because excess polyelectrolytes are usually employed in the surface modification process, it is critical to evaluate different purification strategies to obtain a clean final product and thus avoid ambiguities in the source of effects on biological systems. In this work, 4 nm diameter gold nanoparticles (AuNPs) were wrapped with 15 kDa poly(allylamine hydrochloride) (PAH), and three purification strategies were applied: (a) diafiltration or either (b) one round or (c) two rounds of centrifugation...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28078707/commentary-on-mcauley-et-al-2017-naloxone-programs-must-reduce-marginalization-and-improve-access-to-comprehensive-emergency-care
#14
Aaron M Orkin, Daniel Z Buchman
No abstract text is available yet for this article.
February 2017: Addiction
https://www.readbyqxmd.com/read/28077804/the-complex-genetics-of-gait-speed-genome-wide-meta-analysis-approach
#15
Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L Lunetta, Jennifer A Smith, John D Eicher, Rotem Vered, Joris Deelen, Alice M Arnold, Aron S Buchman, Toshiko Tanaka, Jessica D Faul, Maria Nethander, Myriam Fornage, Hieab H Adams, Amy M Matteini, Michele L Callisaya, Albert V Smith, Lei Yu, Philip L De Jager, Denis A Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J Launer, Davis S Knopman, Neeta Parimi, Stephen T Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P Mooijaart, David C Liewald, Jeanine J Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J Verlinden, Dan Mellström, Jos N van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J Tranah, Andre G Uitterlinden, David R Weir, Wei Zhao, John M Starr, Andrew D Johnson, M Arfan Ikram, David A Bennett, Steven R Cummings, Ian J Deary, Tamara B Harris, Sharon L R Kardia, Thomas H Mosley, Velandai K Srikanth, Beverly G Windham, Ann B Newman, Jeremy D Walston, Gail Davies, Daniel S Evans, Eline P Slagboom, Luigi Ferrucci, Douglas P Kiel, Joanne M Murabito, Gil Atzmon
Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues...
January 10, 2017: Aging
https://www.readbyqxmd.com/read/28045810/the-protruding-premaxilla-is-our-current-approach-the-right-answer
#16
Katelyn G Bennett, Heather M Hendricks, Todd E Thurston, Steven J Kasten, Christian J Vercler, Steven R Buchman
BACKGROUND: In bilateral cleft patients, surgeons usually attempt to move the premaxillary segment posteriorly. These patients almost always develop maxillary hypoplasia, rendering our current algorithms questionable. The authors sought to determine if the lateral segments are in an appropriate position to serve as a target for movement of the premaxilla. METHODS: Bilateral cleft lip and palate patients treated at the University of Michigan from 1997 to 2015 were reviewed...
March 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28035346/diet-induced-weight-loss-is-sufficient-to-reduce-senescent-cell-number-in-white-adipose-tissue-of-weight-cycled-mice
#17
Edward O List, Elizabeth Jensen, Jesse Kowalski, Mathew Buchman, Darlene E Berryman, John J Kopchick
Previously, our laboratory reported that weight-cycled mice outlive their obese counterparts. To gain a better mechanistic understanding of these results, we evaluated cellular senescence in white adipose tissue (WAT) of lean, obese, and weight cycled mice. Our results show that at the end of a 28 day weight loss cycle cellular senescence is significantly reduced in multiple WAT depots compared to obese mice, which also corresponds to a reduction in circulating activin A (a marker of senescence). These findings suggest that a previously undescribed benefit to weight loss may be a reduction of cellular senescence in WAT...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28031006/catheter-salvage-during-infections-in-patients-receiving-home-parenteral-nutrition
#18
Alan L Buchman
No abstract text is available yet for this article.
January 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28009754/public-solicitation-of-anonymous-organ-donors-a-position-paper-by-the-canadian-society-of-transplantation
#19
Marie-Chantal Fortin, Daniel Buchman, Linda Wright, Jennifer Chandler, Sean Delaney, Todd Fairhead, Rob Gallaher, David Grant, Rebecca Greenberg, David Hartell, Sandra Holdsworth, David Landsberg, Steven Paraskevas, Lee Anne Tibbles, Kimberly Young, Lori West, Atul Humar
No abstract text is available yet for this article.
January 2017: Transplantation
https://www.readbyqxmd.com/read/28005251/investigating-trust-expertise-and-epistemic-injustice-in-chronic-pain
#20
Daniel Z Buchman, Anita Ho, Daniel S Goldberg
Trust is central to the therapeutic relationship, but the epistemic asymmetries between the expert healthcare provider and the patient make the patient, the trustor, vulnerable to the provider, the trustee. The narratives of pain sufferers provide helpful insights into the experience of pain at the juncture of trust, expert knowledge, and the therapeutic relationship. While stories of pain sufferers having their testimonies dismissed are well documented, pain sufferers continue to experience their testimonies as being epistemically downgraded...
December 22, 2016: Journal of Bioethical Inquiry
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