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William C Scott, Christopher K Giardina, Andrew K Pappa, Tatyana E Fontenot, Meredith L Anderson, Margaret T Dillon, Kevin D Brown, Harold C Pillsbury, Oliver F Adunka, Craig A Buchman, Douglas C Fitzpatrick
HYPOTHESIS: The compound action potential (CAP) is a purely neural component of the cochlea's response to sound, and may provide information regarding the existing neural substrate in cochlear implant (CI) subjects that can help account for variance in speech perception outcomes. BACKGROUND: Measurement of the "total response" (TR), or sum of the magnitudes of spectral components in the ongoing responses to tone bursts across frequencies, has been shown to account for 40 to 50% of variance in speech perception outcomes...
October 4, 2016: Otology & Neurotology
Ryan Meili, Sandy Buchman, Ritika Goel, Robert Woollard
No abstract text is available yet for this article.
October 2016: Canadian Family Physician Médecin de Famille Canadien
Ryan Meili, Sandy Buchman, Ritika Goel, Robert Woollard
No abstract text is available yet for this article.
October 2016: Canadian Family Physician Médecin de Famille Canadien
Marthe H R Ludtmann, Plamena R Angelova, Natalia N Ninkina, Sonia Gandhi, Vladimir L Buchman, Andrey Y Abramov
: Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded α-synuclein is limited. Using brains of mice lacking α-, β-, and γ-synuclein, we report that extracellular monomeric α-synuclein enters neurons and localizes to mitochondria, interacts with ATP synthase subunit α, and modulates ATP synthase function. Using a combination of biochemical, live-cell imaging and mitochondrial respiration analysis, we found that brain mitochondria of α-, β-, and γ-synuclein knock-out mice are uncoupled, as characterized by increased mitochondrial respiration and reduced mitochondrial membrane potential...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jennifer M Buchman-Schmitt, Sarah J Brislin, Noah C Venables, Thomas E Joiner, Christopher J Patrick
BACKGROUND: The RDoC matrix framework calls for investigation of mental health problems through analysis of core biobehavioral processes quantified and studied across multiple domains of measurement. Critics have raised concerns about RDoC, including overemphasis on biological concepts/measures and disregard for the principle of multifinality, which holds that identical biological predispositions can give rise to differing behavioral outcomes. The current work illustrates an ontogenetic process approach to addressing these concerns, focusing on biobehavioral traits corresponding to RDoC constructs as predictors, and suicidal behavior as the outcome variable...
October 1, 2016: Journal of Affective Disorders
Kavitha Ranganathan, Danielle Shapiro, Noelle E Carlozzi, Michaella Baker, Christian J Vercler, Steven J Kasten, Seth A Warschausky, Steven R Buchman, Jennifer F Waljee
BACKGROUND: Health-related quality of life is inconsistently captured among children with cleft lip and palate. The Patient-Reported Outcomes Measurement Information System (PROMIS) captures health-related quality of life, with the added benefit of comparability across clinical conditions. In this study, the authors define the validity and feasibility of PROMIS among children with clefts. METHODS: Children with cleft lip and palate who were at least 5 years old and able to complete instruments independently were eligible for inclusion (n = 93)...
October 2016: Plastic and Reconstructive Surgery
J Thomas Roland, Craig Buchman, Laurie Eisenberg, Lillian Henderson, Shuman He, Jill Firszt, Howard Francis, Camille Dunn, Doug Sladen, Susan Arndt, Bradford May, Daniel Zeitler, John K Niparko, Susan Emmett, Debara Tucci, Joseph Chen, Amy McConkey Robbins, Ernest Schwefler, Ann Geers, Amy Lederberg, Heather Hayes, Michelle Hughes, Julie Bierer, Erin Schafer, Donna Sorkin, Linda Kozma-Spytek, Tina Childress
No abstract text is available yet for this article.
September 2016: Cochlear Implants International
Sandy Buchman, Linda Rozmovits, Richard H Glazier
OBJECTIVE: To investigate overall colorectal cancer (CRC) screening rates, patterns in the use of types of CRC screening, and sociodemographic characteristics associated with CRC screening; and to gain insight into physicians' perceptions about and use of fecal occult blood testing [FOBT] and colonoscopy for patients at average risk of CRC. DESIGN: Mixed-methods study using cross-sectional administrative data on patient sociodemographic characteristics and semistructured telephone interviews with physicians...
April 2016: Canadian Family Physician Médecin de Famille Canadien
Natalie Connor-Robson, Owen M Peters, Steven Millership, Natalia Ninkina, Vladimir L Buchman
Synucleins are involved in multiple steps of the neurotransmitter turnover, but the largely normal synaptic function in young adult animals completely lacking synucleins suggests their roles are dispensable for execution of these processes. Instead, they may be utilized for boosting the efficiency of certain molecular mechanisms in presynaptic terminals, with a deficiency of synuclein proteins sensitizing to or exacerbating synaptic malfunction caused by accumulation of mild alterations, which are commonly associated with aging...
October 2016: Neurobiology of Aging
Tavora Buchman, Celina Cabello
CONTEXT: Tuberculosis (TB) treatment completion is in part determined by patient's adherence to long-term drug regimens. To best ensure compliance, directly observed therapy (DOT) is considered the standard of practice. Nassau County Department of Health TB Control is responsible for providing DOT to patients with TB. OBJECTIVE: Tuberculosis Control sought to use and evaluate Skype Observed Therapy (SOT) as an alternative to DOT for eligible patients. DESIGN: The evaluation included analysis of patient's acceptance and adherence to drug regimen using SOT...
September 2, 2016: Journal of Public Health Management and Practice: JPHMP
Lei Yu, Robert J Dawe, Aron S Buchman, Patricia A Boyle, Julie A Schneider, Konstantinos Arfanakis, David A Bennett
Alterations of the transverse relaxation rate, R2, measured using MRI, are observed in older persons with Alzheimer's (AD) dementia. However, the spatial pattern of these alterations and the degree to which they reflect the accumulation of common age-related neuropathologies are unknown. In this study, we characterized the profile of R2 alterations in post-mortem brains of persons with clinical diagnosis of AD dementia and investigated how the profile differs after accounting for neuropathologic indices of AD, cerebral infarcts, Lewy body disease, hippocampal sclerosis and transactive response DNA-binding protein 43...
September 2, 2016: Behavioural Brain Research
Shuman He, Tyler C McFayden, Holly F B Teagle, Matthew Ewend, Lillian Henderson, Craig A Buchman
OBJECTIVE: This study aimed to (1) characterize morphological characteristics of the electrically evoked cortical auditory event-related potentials (eERPs) and explore the potential association between onset eERP morphology and auditory versus nonauditory stimulation; (2) assess test-retest reliability of onset eERPs; (3) investigate effects of stimulation level on onset eERPs; and (4) explore the feasibility of using the onset eERP to estimate the lowest stimulation level that can be detected for individual stimulating electrodes in patients with auditory brainstem implants (ABIs)...
August 30, 2016: Ear and Hearing
Aner Weiss, Anat Mirelman, Nir Giladi, Lisa L Barnes, David A Bennett, Aron S Buchman, Jeffrey M Hausdorff
OBJECTIVE: The Timed Up and Go (TUG), one of the most widely used tests of mobility, has been validated and associated with adverse outcomes in the community, acute care, and nursing home setting. It is composed of several distinct subtasks; however, the temporal relationship when transitioning between subtasks has not been well-studied. We tested the hypothesis that longer transition durations between the final turn to the sitting subtasks are associated with worse motor and cognitive performance in older adults...
September 1, 2016: Journal of the American Medical Directors Association
Peter M Vila, Judith E C Lieu, Timothy E Hullar, Craig A Buchman
The study objective was to develop quality measures for adult cochlear implant centers. A modified Delphi design beginning with focus groups of surgeons and audiologists was used, as adapted from the American College of Cardiology / American Heart Association method for creating quality measures. Two academic cochlear implant programs and 1 private program participated. Qualitative focus group analysis yielded 58 candidate measures. An additional 5 candidate measures were added from a systematic review of the literature...
August 23, 2016: Otolaryngology—Head and Neck Surgery
Timothy G Buchman, Timothy R Billiar, Eric Elster, Allan D Kirk, Ramzy H Rimawi, Yoram Vodovotz, Barbara A Zehnbauer
No abstract text is available yet for this article.
September 2016: Critical Care Medicine
Aron S Buchman, Sue E Leurgans, Lei Yu, Robert S Wilson, Andrew S Lim, Bryan D James, Joshua M Shulman, David A Bennett
OBJECTIVE: To determine the incidence of parkinsonism in community-dwelling older adults without Parkinson disease. METHODS: Four parkinsonian signs were assessed with a modified motor portion of the Unified Parkinson's Disease Rating Scale in 2,001 older adults without parkinsonism. We used Cox proportional hazards models to determine the associations of age and sex with incident parkinsonism (2 or more signs). We calculated the number of events per 1,000 person-years of observation in 3 age strata...
September 6, 2016: Neurology
Kavitha Ranganathan, Danielle Shapiro, Oluseyi Aliu, Christian J Vercler, Michaella Baker, Steven J Kasten, Seth A Warschausky, Steven R Buchman, Jennifer F Waljee
PURPOSE: Children with cleft lip with or without palate (CLCP) require multiple reconstructive procedures, however, little is known about their desire for surgical revision. The purpose of this study was to examine the relationship between health-related quality of life (HRQOL) and the desire for revision. METHODS: The authors surveyed children with CLCP (n = 71) and their caregivers regarding general and cleft-specific HRQOL and the desire for revision surgery...
October 2016: Journal of Craniofacial Surgery
Robert J Dawe, Lei Yu, Sue E Leurgans, Julie A Schneider, Aron S Buchman, Konstantinos Arfanakis, David A Bennett, Patricia A Boyle
This study tested the hypothesis that indices of brain tissue integrity derived from postmortem magnetic resonance imaging (MRI) are associated with late life decline in cognitive function and dementia, over and above contributions from common age-related neuropathologies. Cerebral hemispheres were obtained from 425 deceased older adults who had undergone 2 or more annual cognitive assessments, which included clinical diagnosis of dementia. Specimens underwent MRI to produce maps of transverse relaxation rate, R2...
September 2016: Neurobiology of Aging
Guilherme T Valenca, Gyan P Srivastava, Jamary Oliveira-Filho, Charles C White, Lei Yu, Julie A Schneider, Aron S Buchman, Joshua M Shulman, David A Bennett, Philip L De Jager
BACKGROUND AND OBJECTIVE: Recently, we have shown that the Parkinson's disease (PD) susceptibility locus MAPT (microtubule associated protein tau) is associated with parkinsonism in older adults without a clinical diagnosis of PD. In this study, we investigated the relationship between parkinsonian signs and MAPT transcripts by assessing the effect of MAPT haplotypes on alternative splicing and expression levels of the most common isoforms in two prospective clinicopathologic studies of aging...
2016: PloS One
S Verrier, M Alini, E Alsberg, S R Buchman, D Kelly, M W Laschke, M D Menger, W L Murphy, J P Stegemann, M Schütz, T Miclau, M J Stoddart, C Evans
Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and remain a clinical challenge. Healing such defects requires the formation of large amounts of bone in an environment often rendered hostile to osteogenesis by damage to the surrounding soft tissues and vasculature. In recent years, there have been intensive research efforts directed towards tissue engineering and regenerative approaches designed to overcome this multifaceted challenge. In this paper, we describe and critically evaluate the state-of-the-art approaches to address the various components of this intricate problem...
2016: European Cells & Materials
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