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https://www.readbyqxmd.com/read/29131578/optically-detected-magnetic-resonance-for-selective-imaging-of-diamond-nanoparticles
#1
Margaret E Robinson, James D Ng, Huilong Zhang, Joseph T Buchman, Olga A Shenderova, Christy L Haynes, Zhenqiang Ma, Randall H Goldsmith, Robert J Hamers
While there is great interest in understanding the fate and transport of nanomaterials in the environment and in biological systems, the detection of nanomaterials in complex matrices by fluorescence methods is complicated by photodegradation, blinking, and by the presence of natural organic material and other fluorescent background signals that hamper detection of fluorescent nanomaterials of interest. Optically detected magnetic resonance (ODMR) of nitrogen-vacancy (NV) centers in diamond nanoparticles provides a pathway toward background-free fluorescence measurements, as the application of a resonant microwave field can selectively modulate the intensity from NV centers in the diamond in nanodiamonds of various diameters in complex materials systems using on-resonance and off-resonance microwave fields...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29116125/erratum-large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#2
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephen C J Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichmann, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
A correction to this article has been published and is linked from the HTML version of this article.
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29084334/association-between-brain-gene-expression-dna-methylation-and-alteration-of-ex-vivo-magnetic-resonance-imaging-transverse-relaxation-in-late-life-cognitive-decline
#3
Lei Yu, Robert J Dawe, Patricia A Boyle, Chris Gaiteri, Jingyun Yang, Aron S Buchman, Julie A Schneider, Konstantinos Arfanakis, Philip L De Jager, David A Bennett
Importance: Alteration of ex vivo magnetic resonance imaging transverse relaxation is associated with late-life cognitive decline even after controlling for common neuropathologic conditions. However, the underlying neurobiology of this association is unknown. Objective: To investigate the association between brain gene expression, DNA methylation, and alteration of magnetic resonance imaging transverse relaxation in late-life cognitive decline. Design, Setting, and Participants: Data came from 2 community-based longitudinal cohort studies of aging and dementia, the Religious Orders Study, which began in 1993, and the Rush Memory and Aging Project, which began in 1997...
October 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29082554/sleep-fragmentation-and-parkinson-s-disease-pathology-in-older-adults-without-parkinson-s-disease
#4
Shahmir Sohail, Lei Yu, Julie A Schneider, David A Bennett, Aron S Buchman, Andrew S P Lim
INTRODUCTION: Patients with Parkinson's disease (PD) frequently experience disrupted sleep, and several sleep abnormalities are associated with an increased risk of incident PD. However, there are few data concerning the relationship between objectively quantified sleep disruption and the cardinal histopathological features of PD, especially in individuals without clinical PD. METHODS: We studied 269 older adults without PD who had participated in the Rush Memory and Aging Project and undergone uniform structured neuropathologic evaluations upon death...
October 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29072480/the-interpersonal-theory-of-suicide-a-systematic-review-and-meta-analysis-of-a-decade-of-cross-national-research
#5
Carol Chu, Jennifer M Buchman-Schmitt, Ian H Stanley, Melanie A Hom, Raymond P Tucker, Christopher R Hagan, Megan L Rogers, Matthew C Podlogar, Bruno Chiurliza, Fallon B Ringer, Matthew S Michaels, Connor H G Patros, Thomas E Joiner
Over the past decade, the interpersonal theory of suicide has contributed to substantial advances in the scientific and clinical understanding of suicide and related conditions. The interpersonal theory of suicide posits that suicidal desire emerges when individuals experience intractable feelings of perceived burdensomeness and thwarted belongingness and near-lethal or lethal suicidal behavior occurs in the presence of suicidal desire and capability for suicide. A growing number of studies have tested these posited pathways in various samples; however, these findings have yet to be evaluated meta-analytically...
October 26, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29068967/surgical-hypercorrection-of-trigonocephaly-evaluation-of-surgical-outcomes
#6
Katelyn G Bennett, Fan Liang, Kavitha Ranganathan, Karin M Muraszko, Christian J Vercler, Steven R Buchman
BACKGROUND: A lasting correction of trigonocephaly is difficult to achieve, as a durable correction requires significant expansion to overcome galeal restriction and soft tissue recoil of the scalp. High rates of relapse have been reported throughout the literature. The specific aim of this study was to determine if the senior author's method of "hypercorrection" decreases relapse and the need for subsequent revisional surgery. METHODS: Patients who underwent operative correction of metopic craniosynostosis between 1988 and 2011 were reviewed...
October 24, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29064688/enantioselective-total-synthesis-of-antibiotic-cj-16-264-synthesis-and-biological-evaluation-of-designed-analogues-and-discovery-of-highly-potent-and-simpler-antibacterial-agents
#7
K C Nicolaou, Kiran Kumar Pulukuri, Stephan Rigol, Marek Buchman, Akshay A Shah, Nicholas Cen, Megan D McCurry, Kathryn Beabout, Yousif Shamoo
An improved and enantioselective total synthesis of antibiotic CJ-16,264 through a practical kinetic resolution and an iodolactonization reaction to form the iodo pyrrolizidinone fragment of the molecule is described. A series of racemic and enantiopure analogues of CJ-16,264 was designed and synthesized through the developed synthetic technologies and tested against drug-resistant bacterial strains. These studies led to interesting structure-activity relationships and the identification of a number of simpler, and yet equipotent, or even more potent, antibacterial agents than the natural product, thereby setting the foundation for further investigations in the quest for new anti-infective drugs...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29064682/total-syntheses-of-disorazoles-a1-and-b1-and-full-structural-elucidation-of-disorazole-b1
#8
K C Nicolaou, Gabriel Bellavance, Marek Buchman, Kiran Kumar Pulukuri
Described herein are the first total syntheses of naturally occurring antitumor agents disorazoles A1 and B1 and the full structural assignment of the latter. The syntheses were achieved through convergent strategies employing enantioselective constructions of the required building blocks, including a novel Sharpless epoxidation/enzymatic kinetic resolution of stannane-containing substrates that led selectively to both enantiomeric forms of an epoxy vinyl stannane, and a series of coupling reactions, including a Wittig reaction, a Suzuki coupling, a Stille coupling, a Yamaguchi esterification and a Yamaguchi macrolactonization...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29041190/differential-optical-shadow-sensor-for-sub-nanometer-displacement-measurement-and-its-application-to-drag-free-satellites
#9
Andreas Zoellner, Si Tan, Shailendhar Saraf, Abdul Alfauwaz, Dan DeBra, Sasha Buchman, John A Lipa
We present a method for 3D sub-nanometer displacement measurement using a set of differential optical shadow sensors. It is based on using pairs of collimated beams on opposite sides of an object that are partially blocked by it. Applied to a sphere, our 3-axis sensor module consists of 8 parallel beam-detector sets for redundancy. The sphere blocks half of each beam's power in the nominal centered position, and any displacement can be measured by the differential optical power changes amongst the pairs of detectors...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040146/the-role-of-preoperative-imaging-in-the-management-of-nonsyndromic-lambdoid-craniosynostosis
#10
Kavitha Ranganathan, Antonio Rampazzo, Asra Hashmi, Karin Muraszko, Jennifer Strahle, Christian J Vercler, Steven R Buchman
BACKGROUND: The necessity of imaging for patients with craniosynostosis is controversial. Lambdoid synostosis is known to be associated with additional anomalies, but the role of imaging in this setting has not been established. The purpose of this study was to evaluate the impact of preoperative imaging on intraoperative and postoperative management among patients undergoing operative intervention for lambdoid craniosynostosis. METHODS: A retrospective review of patients undergoing cranial vault remodeling for lambdoid craniosynostosis between January 2006 and 2014 was conducted...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29023243/pediatric-auditory-brainstem-implantation-surgical-electrophysiologic-and-behavioral-outcomes
#11
Holly F B Teagle, Lillian Henderson, Shuman He, Matthew G Ewend, Craig A Buchman
OBJECTIVES: The objectives of this study were to demonstrate the safety of auditory brainstem implant (ABI) surgery and document the subsequent development of auditory and spoken language skills in children without neurofibromatosis type II (NFII). DESIGN: A prospective, single-subject observational study of ABI in children without NFII was undertaken at the University of North Carolina at Chapel Hill. Five children were enrolled under an investigational device exemption sponsored by the investigators...
October 11, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28968281/the-electrically-evoked-auditory-change-complex-evoked-by-temporal-gaps-using-cochlear-implants-or-auditory-brainstem-implants-in-children-with-cochlear-nerve-deficiency
#12
Shuman He, Tyler C McFayden, Bahar S Shahsavarani, Holly F B Teagle, Matthew Ewend, Lillian Henderson, Craig A Buchman
OBJECTIVES: This study aimed to (1) establish the feasibility of measuring the electrically evoked auditory change complex (eACC) in response to temporal gaps in children with cochlear nerve deficiency (CND) who are using cochlear implants (CIs) and/or auditory brainstem implants (ABIs); and (2) explore the association between neural encoding of, and perceptual sensitivity to, temporal gaps in these patients. DESIGN: Study participants included 5 children (S1 to S5) ranging in age from 3...
September 29, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28960595/spinal-lewy-body-pathology-in-older-adults-without-an-antemortem-diagnosis-of-parkinson-s-disease
#13
Aron S Buchman, Sukriti Nag, Sue E Leurgans, Jared Miller, Veronique G J M VanderHorst, David A Bennett, Julie A Schneider
To test the hypothesis that Lewy body pathology (LBs) is present in the spinal cord of older community-dwelling adults without a clinical diagnosis of Parkinson's disease (PD). We studied 162 prospective autopsies from older adults with PD (N = 6) and without PD (N = 156). We documented the presence of LBs in cerebrum and brainstem structures from each of the six regions used for Braak PD staging and four spinal cord levels (C5/6, T7, L4/5 and S4/5). Parkinsonism proximate to death was based on a previously validated measure present if two or more of the four signs of parkinsonism were present based on a modified version of the Unified Parkinson's Disease Rating Scale (UPDRS)...
September 28, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28957994/association-between-quantitative-gait-and-balance-measures-and-total-daily-physical-activity-in-community-dwelling-older-adults
#14
Robert J Dawe, Sue E Leurgans, Jingyun Yang, Joshua M Bennett, Jeffrey M Hausdorff, Andrew S Lim, Chris Gaiteri, David A Bennett, Aron S Buchman
Background: Total daily physical activity is associated with a wide range of adverse health outcomes. We examined the extent to which quantitative measures of gait and balance abilities were associated with total daily physical activity, controlling for a variety of potential covariates. Methods: Participants (n=608) were older adults participating in the Rush Memory and Aging Project, a community-based cohort study of aging. Objective measures of total daily physical activity were derived from a wearable device...
August 30, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28931619/spinal-arteriolosclerosis-is-common-in-older-adults-and-associated-with-parkinsonism
#15
Aron S Buchman, Sue E Leurgans, Sukriti Nag, Veronique G J M VanderHorst, Alifiya Kapasi, Julie A Schneider, David A Bennett
BACKGROUND AND PURPOSE: There are few studies of spinal microvascular pathologies in older adults. We characterized spinal cord microvascular pathologies and examined their associations with other spinal and brain postmortem indices and parkinsonism in older adults. METHODS: We documented 3 features of microvascular pathologies in spinal cord and brain specimens from 165 deceased older participants. We also measured spinal white matter pallor. Parkinsonian signs were assessed with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale...
October 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28930778/radioprotection-with-amifostine-enhances-bone-strength-and-regeneration-and-bony-union-in-a-rat-model-of-mandibular-distraction-osteogenesis
#16
Catherine N Tchanque-Fossuo, Alexis Donneys, Sagar S Deshpande, Deniz Sarhaddi, Noah S Nelson, Laura A Monson, Sara E Dahle, Steve A Goldstein, Steven R Buchman
BACKGROUND: Using distraction osteogenesis (DO) to regenerate robust endogenous bone could greatly enhance postoncologic reconstruction of head and neck cancer. However, radiation (XRT) corrosive effects still preclude DO's immense potential. We posit that adjunctive pretreatment with the radioprotectant amifostine (AMF) can optimize wound healing and allow for successful DO with quantifiable enhancements in bony union and strength despite previous surgical bed irradiation. METHODS: Two groups of murine left hemimandibles were exposed to a human equivalent radiation dosage fractionated over 5 daily doses of 7 Gy...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28925929/canadian-guidelines-for-controlled-pediatric-donation-after-circulatory-determination-of-death-summary-report
#17
Matthew J Weiss, Laura Hornby, Bram Rochwerg, Michael van Manen, Sonny Dhanani, V Ben Sivarajan, Amber Appleby, Mary Bennett, Daniel Buchman, Catherine Farrell, Aviva Goldberg, Rebecca Greenberg, Ram Singh, Thomas A Nakagawa, William Witteman, Jill Barter, Allon Beck, Kevin Coughlin, Alf Conradi, Cynthia Cupido, Rosanne Dawson, Anne Dipchand, Darren Freed, Karen Hornby, Valerie Langlois, Cheryl Mack, Meagan Mahoney, Deepak Manhas, Christopher Tomlinson, Samara Zavalkoff, Sam D Shemie
OBJECTIVES: Create trustworthy, rigorous, national clinical practice guidelines for the practice of pediatric donation after circulatory determination of death in Canada. METHODS: We followed a process of clinical practice guideline development based on World Health Organization and Canadian Medical Association methods. This included application of Grading of Recommendations Assessment, Development, and Evaluation methodology. Questions requiring recommendations were generated based on 1) 2006 Canadian donation after circulatory determination of death guidelines (not pediatric specific), 2) a multidisciplinary symposium of national and international pediatric donation after circulatory determination of death leaders, and 3) a scoping review of the pediatric donation after circulatory determination of death literature...
November 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28906286/serial-daily-organ-failure-assessment-beyond-icu-day-5-does-not-independently-add-precision-to-icu-risk-of-death-prediction
#18
Andre L Holder, Elizabeth Overton, Peter Lyu, Jordan A Kempker, Shamim Nemati, Fereshteh Razmi, Greg S Martin, Timothy G Buchman, David J Murphy
OBJECTIVES: To identify circumstances in which repeated measures of organ failure would improve mortality prediction in ICU patients. DESIGN: Retrospective cohort study, with external validation in a deidentified ICU database. SETTING: Eleven ICUs in three university hospitals within an academic healthcare system in 2014. PATIENTS: Adults (18 yr old or older) who satisfied the following criteria: 1) two of four systemic inflammatory response syndrome criteria plus an ordered blood culture, all within 24 hours of hospital admission; and 2) ICU admission for at least 2 calendar days, within 72 hours of emergency department presentation...
December 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28902802/audiological-outcomes-and-map-characteristics-in-children-with-perimodiolar-and-slim-straight-array-cochlear-implants-in-opposite-ears
#19
Lisa R Park, Holly F B Teagle, Kevin D Brown, Erika B Gagnon, Jennifer S Woodard, Craig A Buchman
OBJECTIVE: To identify differences in outcomes and map characteristics in pediatric bilateral cochlear implants with modiolar conforming and lateral wall arrays in opposite ears. STUDY DESIGN: Retrospective case series. SETTING: Tertiary care pediatric referral center. PATIENTS: Fourteen children who received a perimodiolar array in one ear and a slim straight array in the opposite ear in sequential surgeries. INTERVENTIONS: None...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28891823/longitudinal-changes-in-electrically-evoked-auditory-event-related-potentials-in-children-with-auditory-brainstem-implants-preliminary-results-recorded-over-3-years
#20
Shuman He, Holly F B Teagle, Tyler C McFayden, Matthew Ewend, Lillian Henderson, Nancy He, Craig A Buchman
OBJECTIVES: This preliminary study aimed (1) to assess longitudinal changes in electrically evoked auditory event-related potentials (eERPs) in children with auditory brainstem implants (ABIs) and (2) to explore whether these changes could be accounted for by maturation in the central auditory system of these patients. DESIGN: Study participants included 5 children (S1 to S5) with an ABI in the affected ear. The stimulus was a train of electrical pulses delivered to individual ABI electrodes via a research interface...
September 7, 2017: Ear and Hearing
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