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Harlan krumholz

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https://www.readbyqxmd.com/read/29753792/national-and-regional-trends-in-deep-vein-thrombosis-hospitalization-rates-discharge-disposition-and-outcomes-for-medicare-beneficiaries-%C3%A2-%C3%A2-%C3%A2
#1
Karl E Minges, Behnood Bikdeli, Yun Wang, Robert R Attaran, Harlan M Krumholz
INTRODUCTION: Older adults are at increased risk of developing deep vein thrombosis. Little is known about national trends of deep vein thrombosis hospitalizations in the context of primary and secondary prevention efforts. METHODS: Medicare standard analytic files were analyzed from 2015-2017 to identify Fee-For-Service patients aged ≥65 years who had a principal discharge diagnosis for deep vein thrombosis from 1999 to 2010. We reported the deep vein thrombosis hospitalization rates per 100,000 person-years as well as 30-day and 1-year mortality rates...
May 10, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29748344/the-china-patient-centered-evaluative-assessment-of-cardiac-events-china-peace-retrospective-heart-failure-study-design
#2
Yuan Yu, Hongzhao Zhang, Xi Li, Yuan Lu, Frederick A Masoudi, Harlan M Krumholz, Jing Li
INTRODUCTION: Heart failure (HF) is a leading cause of hospitalisation in China, which is experiencing a rapid increase in cardiovascular disease prevalence. Yet, little is known about current burden of disease, quality of care and treatment outcomes of HF in China. The objective of this paper is to describe the study methodology, data collection and abstraction, and progress to date of the China Patient-centered Evaluative Assessment of Cardiac Events 5 Retrospective Heart Failure Study (China PEACE 5r-HF)...
May 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29691411/analysis-of-predicted-loss-of-function-variants-in-uk-biobank-identifies-variants-protective-for-disease
#3
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted loss-of-function (pLOF) variants provide insight into effector transcript and direction of biological effect. In >400,000 UK Biobank participants, we conduct association analyses of 3759 pLOF variants with six metabolic traits, six cardiometabolic diseases, and twelve additional diseases...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#4
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29674521/screening-ecgs-in-low-risk-patients-are-associated-with-increased-risk-of-downstream-cardiac-testing
#5
REVIEW
Shiwani Mahajan, Harlan M Krumholz
No abstract text is available yet for this article.
April 19, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29617967/older-drugs-with-infantile-evidence-the-illustrative-example-of-loop-diuretics
#6
Behnood Bikdeli, Jeffrey M Testani, Joseph S Ross, Harlan M Krumholz
No abstract text is available yet for this article.
March 29, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29582081/publicly-reported-readmission-measures-and-the-hospital-readmissions-reduction-program-a-false-equivalence
#7
Rohan Khera, Leora I Horwitz, Zhenqiu Lin, Harlan M Krumholz
No abstract text is available yet for this article.
March 27, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29566340/reply-to-risk-trajectories-following-hospitalization-for-copd-don-t-short-change-non-invasive-ventilation
#8
Peter K Lindenauer, Kumar Dharmarajan, Harlan M Krumholz
No abstract text is available yet for this article.
March 22, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29562926/comparison-of-treatment-effect-sizes-from-pivotal-and-postapproval-trials-of-novel-therapeutics-approved-by-the-fda-based-on-surrogate-markers-of-disease-a-meta-epidemiological-study
#9
Joshua D Wallach, Oriana Ciani, Alison M Pease, Gregg S Gonsalves, Harlan M Krumholz, Rod S Taylor, Joseph S Ross
BACKGROUND: The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about the medical product's actual clinical effect. This study aims to compare the treatment effects among pivotal trials supporting FDA approval of novel therapeutics based on surrogate markers of disease with those observed among postapproval trials for the same indication...
March 21, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29535091/clinical-outcomes-of-plavix-and-generic-clopidogrel-for-patients-hospitalized-with-an-acute-coronary-syndrome
#10
Dennis T Ko, Harlan M Krumholz, Jack V Tu, Peter C Austin, Therese A Stukel, Maria Koh, Alice Chong, Jose Francisco de Melo, Cynthia A Jackevicius
BACKGROUND: Clopidogrel is one of the most commonly prescribed medications because of its ability to improve clinical outcomes for a broad range of cardiovascular conditions. After patent protection expired for Plavix in 2012, many healthcare systems adopted generic clopidogrel as a strategy to reduce healthcare costs. METHODS AND RESULTS: We conducted a population-based observational study to determine whether generic clopidogrel was noninferior to Plavix. Patients who were hospitalized with an acute coronary syndrome (ACS) from 2009 to 2014 in Ontario, Canada, >65 years, survived ≥7 days after discharge, were eligible for inclusion...
March 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29529049/population-well-being-and-electoral-shifts
#11
Jeph Herrin, Dan Witters, Brita Roy, Carley Riley, Diana Liu, Harlan M Krumholz
Population wellbeing, an aggregate measure of positive mental, physical, and emotional health, has previously been used as a marker of community thriving. We examined whether several community measures of wellbeing, and their change since 2012, could be used to understand electoral changes that led to the outcome of the 2016 United States presidential election. We found that areas of the US which had the largest shifts away from the incumbent party had both lower wellbeing and greater drops in wellbeing when compared with areas that did not shift...
2018: PloS One
https://www.readbyqxmd.com/read/29516100/mass-customization-for-population-health
#12
Kevin G Volpp, Harlan M Krumholz, David A Asch
No abstract text is available yet for this article.
March 7, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29514807/sex-differences-in-timeliness-of-reperfusion-in-young-patients-with-st-segment-elevation-myocardial-infarction-by-initial-electrocardiographic-characteristics
#13
Aakriti Gupta, Jose A Barrabes, Kelly Strait, Hector Bueno, Andreu Porta-Sánchez, J Gabriel Acosta-Vélez, Rosa-Maria Lidón, Erica Spatz, Mary Geda, Rachel P Dreyer, Nancy Lorenze, Judith Lichtman, Gail D'Onofrio, Harlan M Krumholz
BACKGROUND: Young women with ST-segment-elevation myocardial infarction experience reperfusion delays more frequently than men. Our aim was to determine the electrocardiographic correlates of delay in reperfusion in young patients with ST-segment-elevation myocardial infarction. METHODS AND RESULTS: We examined sex differences in initial electrocardiographic characteristics among 1359 patients with ST-segment-elevation myocardial infarction in a prospective, observational, cohort study (2008-2012) of 3501 patients with acute myocardial infarction, 18 to 55 years of age, as part of the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients) study at 103 US and 24 Spanish hospitals enrolling in a 2:1 ratio for women/men...
March 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29513365/ventricular-septal-rupture-complicating-acute-myocardial-infarction-incidence-treatment-and-outcomes-among-medicare-beneficiaries-1999-2014
#14
Andrew M Goldsweig, Yun Wang, John K Forrest, Michael W Cleman, Karl E Minges, Abeel A Mangi, Herbert D Aronow, Harlan M Krumholz, Jeptha P Curtis
OBJECTIVES: The present study was designed to assess whether the incidence and outcomes of VSR-AMI have changed in the era of timely primary PCI. BACKGROUND: Ventricular septal rupture (VSR) is a rare but frequently fatal complication of acute myocardial infarction (AMI). METHODS: We conducted a retrospective cohort study of all Medicare fee-for-service beneficiaries from 1999 to 2014 to examine trends in the incidence, surgical and percutaneous repair, and 30-day and 1-year mortality of VSR-AMI...
March 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29459463/sex-differences-in-the-presentation-and-perception-of-symptoms-among-young-patients-with-myocardial-infarction-evidence-from-the-virgo-study-variation-in-recovery-role-of-gender-on-outcomes-of-young-ami-patients
#15
Judith H Lichtman, Erica C Leifheit, Basmah Safdar, Haikun Bao, Harlan M Krumholz, Nancy P Lorenze, Mitra Daneshvar, John A Spertus, Gail D'Onofrio
BACKGROUND: Some studies report that women are less likely to present with chest pain for acute myocardial infarction (AMI). Information on symptom presentation, perception of symptoms, and care-seeking behaviors is limited for young patients with AMI. METHODS: We interviewed 2009 women and 976 men aged 18 to 55 years hospitalized for AMI at 103 US hospitals participating in the VIRGO study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients)...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29451557/biomedical-journal-speed-and-efficiency-a-cross-sectional-pilot-survey-of-author-experiences
#16
Joshua D Wallach, Alexander C Egilman, Anand D Gopal, Nishwant Swami, Harlan M Krumholz, Joseph S Ross
Background: Although the peer review process is believed to ensure scientific rigor, enhance research quality, and improve manuscript clarity, many investigators are concerned that the process is too slow, too expensive, too unreliable, and too static. In this feasibility study, we sought to survey corresponding authors of recently published clinical research studies on the speed and efficiency of the publication process. Methods: Web-based survey of corresponding authors of a 20% random sample of clinical research studies in MEDLINE-indexed journals with Ovid MEDLINE entry dates between December 1 and 15, 2016...
2018: Research Integrity and Peer Review
https://www.readbyqxmd.com/read/29450464/evaluating-readmission-need-for-more-clarity-on-methods
#17
Harlan M Krumholz, Kumar Dharmarajan, Sharon-Lise T Normand
No abstract text is available yet for this article.
March 1, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29421010/training-cardiovascular-outcomes-researchers-a-survey-of-mentees-and-mentors-to-identify-critical-training-gaps-and-needs
#18
Prateeti Khazanie, Sana M Al-Khatib, Tracy Y Wang, Matthew J Crowley, Nancy R Kressin, Harlan M Krumholz, Catarina I Kiefe, Barbara L Wells, Sean M O'Brien, Eric D Peterson, Gillian D Sanders
BACKGROUND: Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS: From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the United States. We contacted successful grantees of government agencies, members of professional organizations, and trainees in CV outcomes training programs...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29421009/how-well-does-early-career-investigators-cardiovascular-outcomes-research-training-align-with-funded-outcomes-research
#19
Matthew J Crowley, Sana M Al-Khatib, Tracy Y Wang, Prateeti Khazanie, Nancy R Kressin, Harlan M Krumholz, Catarina I Kiefe, Barbara L Wells, Sean M O'Brien, Eric D Peterson, Gillian D Sanders
BACKGROUND: Outcomes research training programs should prepare trainees to successfully compete for research funding. We examined how early-career investigators' prior and desired training aligns with recently funded cardiovascular (CV) outcomes research. METHODS: We (1) reviewed literature to identify 13 core competency areas in CV outcomes research; (2) surveyed early-career investigators to understand their prior and desired training in each competency area; (3) examined recently funded grants commonly pursued by early-career outcomes researchers to ascertain available funding in competency areas; and (4) analyzed alignment between investigator training and funded research in each competency area...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29374046/comparison-of-prevalence-awareness-treatment-and-control-of-cardiovascular-risk-factors-in-china-and-the-united-states
#20
Yuan Lu, Pei Wang, Tianna Zhou, Jiapeng Lu, Erica S Spatz, Khurram Nasir, Lixin Jiang, Harlan M Krumholz
BACKGROUND: The reasons for China's high stroke prevalence are not well understood. The cardiovascular risk factor profiles of China and the United States have not been directly compared in nationally representative population samples. METHODS AND RESULTS: Using data from the CHARLS (China Health and Retirement Longitudinal Study) and the NHANES (US National Health and Nutrition Examination Survey), we compared cardiovascular risk factors from 2011 to 2012 among people aged 45 to 75 years between the 2 countries (China, 12 654 people; United States, 2607 people): blood pressure, cholesterol, body mass index, waist circumference, fasting plasma glucose, hemoglobin A1c, and high-sensitivity C-reactive protein...
January 26, 2018: Journal of the American Heart Association
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