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Paul Bolton

Rachael Reid, Séamus Fanning, Paul Whyte, Joe Kerry, Roland Lindqvist, Zhongyi Yu, Declan Bolton
The primary objective of this study was to characterise (microbiology and physical parameters) beef carcasses and primals during chilled storage. A minor aim was to compare observed growth of key spoilage bacteria on carcasses with that predicted by ComBase and the Food Safety Spoilage Predictor (FSSP). Total viable count (TVC), total Enterobacteriacae count (TEC), Pseudomonas spp., lactic acid bacteria (LAB), Brochothrix thermosphacta and Clostridium spp. were monitored on beef carcasses (n = 30) and primals (n = 105) during chilled storage using EC Decision 2001/471/EC and ISO sampling/laboratory procedures...
February 2017: Food Microbiology
Will T S Miles, Mark Bolton, Peter Davis, Roy Dennis, Roger Broad, Iain Robertson, Nick J Riddiford, Paul V Harvey, Roger Riddington, Deryk N Shaw, David Parnaby, Jane M Reid
Phenological changes in key seasonally expressed life-history traits occurring across periods of climatic and environmental change can cause temporal mismatches between interacting species, and thereby impact population and community dynamics. However, studies quantifying long-term phenological changes have commonly only measured variation occurring in spring, measured as the first or mean dates on which focal traits or events were observed. Few studies have considered seasonally paired events spanning spring and autumn or tested the key assumption that single convenient metrics accurately capture entire event distributions...
September 27, 2016: Global Change Biology
Jeremy C Kane, Laura K Murray, Judith Cohen, Shannon Dorsey, Stephanie Skavenski van Wyk, Jennica Galloway Henderson, Mwiya Imasiku, John Mayeya, Paul Bolton
BACKGROUND: The effectiveness of mental health interventions such as trauma-focused cognitive behavioral therapy (TF-CBT) may vary by client, caregiver, and intervention-level variables, but few randomized trials in low- and middle-income countries (LMIC) have conducted moderation analyses to investigate these characteristics. This study explores moderating factors to TF-CBT treatment response among a sample of orphans and vulnerable children (OVC) in Zambia. METHODS: Data were obtained from a completed randomized trial of TF-CBT among 257 OVC in Zambia...
October 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
John Au, Diana M Perriman, Claire Bolton, Liz Abbott, Teresa Neeman, Paul N Smith
BACKGROUND: The unstable pelvic fracture has been described as the 'killing fracture' because of the risk of significant vascular compromise. The ability to correctly classify pelvic fractures may therefore be crucial in optimizing patient outcomes. Pelvic fracture classification is difficult and previous research has indicated that ability is suboptimal in orthopaedic registrars. The objective of this study was to examine the efficacy of an educational package in improving orthopaedic registrars' ability to classify pelvic fractures...
September 14, 2016: ANZ Journal of Surgery
Judith Bass, Sarah McIvor Murray, Thikra Ahmed Mohammed, Mary Bunn, William Gorman, Ahmed Mohammed Amin Ahmed, Laura Murray, Paul Bolton
Supportive counseling type interventions are frequently provided to meet the mental health needs of populations in emergency and post-conflicts contexts, but it has seldom been rigorously evaluated. Existing evaluations from low- and middle-income countries provide mixed evidence of effectiveness. While Iraqi Kurdistan experienced relative stability following the fall of Saddam Hussein's government, the population in the northern Dohuk region has continued to experience periodic violence due to conflicts with neighboring Turkey as well as more recent ISIS-associated violence...
September 28, 2016: Global Health, Science and Practice
Emily C Stratta, David M Riding, Paul Baker
OBJECTIVES: This study sought to understand whether UK Foundation doctors perceived the phenomena of ethical erosion and empathy decline during their initial period of clinical practice, and if so, why this occurred. METHODS: This qualitative study used semi-structured interviews with nine doctors in their first year of clinical practice at Royal Bolton Hospital, UK. Participants were invited to discuss the definition of empathy, how individuals acquire and maintain empathic ability, perceptions of ethical erosion in the self and others, and how clinical experiences have influenced their empathic ability...
2016: International Journal of Medical Education
Agathe Auer, Nathan H Vande Burgt, Florence Abram, Gerald Barry, Owen Fenton, Bryan K Markey, Stephen Nolan, Karl Richards, Declan Bolton, Theo De Waal, Stephen V Gordon, Vincent O'Flaherty, Paul Whyte, Annetta Zintl
The process of anaerobic digestion (AD) is valued as a carbon-neutral energy source, while simultaneously treating organic waste, making it safer for disposal or use as a fertilizer on agricultural land. The AD process in many European nations, such as Germany, has grown from use of small, localized digesters to the operation of large-scale treatment facilities, which contribute significantly to national renewable energy quotas. However, these large AD plants are costly to run and demand intensive farming of energy crops for feedstock...
August 24, 2016: Journal of the Science of Food and Agriculture
Amanda J Nguyen, Concetta Feo, Kyuri Idrisov, Giovanni Pintaldi, Annick Lenglet, Zalina Tsatsaeva, Paul Bolton, Judith Bass
BACKGROUND: A decade of conflict in Chechnya destroyed infrastructure and resulted in widespread exposure to violence. Amidst substantial reconstruction, periodic violence has contributed to an ongoing atmosphere of insecurity. We conducted a qualitative study to understand the mental health and psychosocial problems affecting adult Chechens in this context to inform development of assessment tools for an evaluation study related to individual counseling. METHODS: Data were collected in July 2014...
2016: Conflict and Health
Ben Johnson, Gillian C Lowe, Jane Futterer, Marie Lordkipanidzé, David MacDonald, Michael A Simpson, Isabel Sanchez-Guiú, Sian Drake, Danai Bem, Vincenzo Leo, Sarah J Fletcher, Ban Dawood, José Rivera, David Allsup, Tina Biss, Paula Hb Bolton-Maggs, Peter Collins, Nicola Curry, Charlotte Grimley, Beki James, Mike Makris, Jayashree Motwani, Sue Pavord, Katherine Talks, Jecko Thachil, Jonathan Wilde, Mike Williams, Paul Harrison, Paul Gissen, Stuart Mundell, Andrew Mumford, Martina E Daly, Steve P Watson, Neil V Morgan
Inherited thrombocytopenias are a heterogeneous group of disorders characterized by abnormally low platelet counts which can be associated with abnormal bleeding. Next-generation sequencing has previously been employed in these disorders for the confirmation of suspected genetic abnormalities, and more recently in the discovery of novel disease-causing genes. However its full potential has not yet been exploited. Over the past 6 years we have sequenced the exomes from 55 patients, including 37 index cases and 18 additional family members, all of whom were recruited to the UK Genotyping and Phenotyping of Platelets study...
October 2016: Haematologica
David C Cron, Michael J Englesbe, Christian J Bolton, Melvin T Joseph, Kristen L Carrier, Stephanie E Moser, Jennifer F Waljee, Paul E Hilliard, Sachin Kheterpal, Chad M Brummett
OBJECTIVE: To explore the clinical and financial implications of preoperative opioid use in major abdominal surgery. BACKGROUND: Opioids are increasingly used to manage chronic pain, and chronic opioid users are challenging to care for perioperatively. Given the epidemic of opioid-related morbidity and mortality, it is critical to understand how preoperative opioid use impacts surgical outcomes. METHODS: This was an analysis of nonemergent, abdominopelvic surgeries from 2008 to 2014 from a single center within the Michigan Surgical Quality Collaborative clinical registry database...
July 15, 2016: Annals of Surgery
Jeremy C Kane, Laura K Murray, Judith K Bass, Renee M Johnson, Paul Bolton
BACKGROUND: Substance and alcohol misuse is a global problem that increases the risk of HIV infection. This is a concern among orphans and vulnerable children (OVC) in sub-Saharan Africa who may have elevated substance use rates. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) is a reliable and valid instrument of substance use among adults in primary care high-income settings. This study examined psychometric properties of the ASSIST among OVC in Zambia using Audio Computer Assisted Self-Interviewing (ACASI)...
September 1, 2016: Drug and Alcohol Dependence
S Nyambe, C Burgess, P Whyte, D Bolton
AIMS: Cattle are the main reservoir of verocytotoxigenic Escherichia coli (VTEC), food-borne pathogens that express verocytotoxins (vtx) encoded by temperate bacteriophage. Bovine faeces and unturned manure heaps can support the survival of VTEC and may propagate and transmit VTEC. This study investigated the survival of a vtx2 bacteriophage, φ24B ::Kan, in bovine faeces and slurry. The survival of an anti-Escherichia coli O157:H7 lytic bacteriophage, e11/2, was examined in the same matrices, as a possible bio-control option for VTEC...
October 2016: Journal of Applied Microbiology
Shaun Smith, Joseph Meade, James Gibbons, Kevina McGill, Declan Bolton, Paul Whyte
INTRODUCTION: Campylobacter jejuni is the leading bacterial food-borne pathogen within the European Union, and poultry meat is an important vehicle for its transmission to humans. However, there is limited knowledge about how this organism persists in broiler litter and faeces. The aim of this study was to assess the impact of a number of environmental parameters, such as temperature, humidity, and oxygen, on Campylobacter survival in both broiler litter and faeces. MATERIALS AND METHODS: Used litter was collected from a Campylobacter-negative broiler house after final depopulation and fresh faeces were collected from transport crates...
2016: Infection Ecology & Epidemiology
Sunghwan Kim, Paul A Thiessen, Tiejun Cheng, Bo Yu, Benjamin A Shoemaker, Jiyao Wang, Evan E Bolton, Yanli Wang, Stephen H Bryant
BACKGROUND: PubChem is an open archive consisting of a set of three primary public databases (BioAssay, Compound, and Substance). It contains information on a broad range of chemical entities, including small molecules, lipids, carbohydrates, and (chemically modified) amino acid and nucleic acid sequences (including siRNA and miRNA). Currently (as of Nov. 2015), PubChem contains more than 150 million depositor-provided chemical substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results provided from over 1 million biological assay records...
2016: Journal of Cheminformatics
J Dudziak, N Bolton, G McNeil, V Paul, A Raithatha, G Rogers, K Booker, E Lima, P Jeanrenaud, K Sim, C Wong, A Mohammed, V Mahendran, I Welters, A Tridente
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Ayal Schaffer, Mark Sinyor, Paul Kurdyak, Simone Vigod, Jitender Sareen, Catherine Reis, Diane Green, James Bolton, Anne Rhodes, Sophie Grigoriadis, John Cairney, Amy Cheung
The objective of this study was to detail the nature and correlates of mental health and non-mental health care contacts prior to suicide death. We conducted a systematic extraction of data from records at the Office of the Chief Coroner of Ontario of each person who died by suicide in the city of Toronto from 1998 to 2011. Data on 2,835 suicide deaths were linked with provincial health administrative data to identify health care contacts during the 12 months prior to suicide. Sub-populations of suicide decedents based on the presence and type of mental health care contact were described and compared across socio-demographic, clinical and suicide-specific variables...
June 2016: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Avinandan Saha, Stefan Louis Botha, Paul Weaving, Giovanni Satta
BACKGROUND: Peracetic acid sporicidal wipes have been shown to be an effective disinfectant, but in controlled test environments. Their high cost may restrict use. AIMS: This pilot study investigated the efficacy and compared the costs of routine universal use of peracetic acid sporicidal wipes versus sporicidal quaternary ammonium compound and alcohol wipes in the disinfection of a hospital environment. METHODS: The routine universal use of peracetic acid wipes (Clinell Sporicidal; GAMA Healthcare Ltd, London, UK) was allocated to a study ward, whereas the control ward continued with the use of quaternary ammonium compound wipes (Tuffie 5; Vernacare, Bolton, UK) and alcohol wipes (PDI Sani-Cloth 70; PDI, Flint, UK)...
May 26, 2016: American Journal of Infection Control
Shaun Smith, Locksley L McV Messam, Joseph Meade, James Gibbons, Kevina McGill, Declan Bolton, Paul Whyte
BACKGROUND: Campylobacter jejuni is the leading bacterial food-borne pathogen within the European Union (EU), and poultry meat is the primary route for transmission to humans. MATERIAL AND METHODS: This study examined the impact of partial depopulation (thinning), season, and farm performance (economic, hygiene, and biosecurity) on Campylobacter prevalence in Irish broilers over a 13-month period. Ten caecal samples were taken per flock, for a total of 211 flocks from 23 farms during the duration of the study...
2016: Infection Ecology & Epidemiology
Tara Battersby, Desmond Walsh, Paul Whyte, Declan J Bolton
BACKGROUND: The objective of this study was to characterise Campylobacter growth in enrichment broths (Bolton broth, brain heart infusion broth), caecal material (in vitro), and in the naturally infected live broilers (in vivo) in terms of mean lag periods and generation times as well as maximum growth rates and population (cell concentration) achieved. METHODS: Bolton and brain heart infusion broths and recovered caecal material were inoculated with 10 poultry strains of Campylobacter (eight Campylobacter jejuni and two Campylobacter coli), incubated under microaerobic conditions, and Campylobacter concentrations determined periodically using the ISO 10272:2006 method...
2016: Infection Ecology & Epidemiology
Paul D Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A Bell, Helen M Berman, Talapady N Bhat, Jeff M Blaney, Evan Bolton, Gerard Bricogne, David Brown, Stephen K Burley, David A Case, Kirk L Clark, Tom Darden, Paul Emsley, Victoria A Feher, Zukang Feng, Colin R Groom, Seth F Harris, Jorg Hendle, Thomas Holder, Andrzej Joachimiak, Gerard J Kleywegt, Tobias Krojer, Joseph Marcotrigiano, Alan E Mark, John L Markley, Matthew Miller, Wladek Minor, Gaetano T Montelione, Garib Murshudov, Atsushi Nakagawa, Haruki Nakamura, Anthony Nicholls, Marc Nicklaus, Robert T Nolte, Anil K Padyana, Catherine E Peishoff, Susan Pieniazek, Randy J Read, Chenghua Shao, Steven Sheriff, Oliver Smart, Stephen Soisson, John Spurlino, Terry Stouch, Radka Svobodova, Wolfram Tempel, Thomas C Terwilliger, Dale Tronrud, Sameer Velankar, Suzanna C Ward, Gregory L Warren, John D Westbrook, Pamela Williams, Huanwang Yang, Jasmine Young
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive, ∼75% include at least one non-polymeric ligand. Ligand geometrical and stereochemical quality, the suitability of ligand models for in silico drug discovery and design, and the goodness-of-fit of ligand models to electron-density maps vary widely across the archive...
April 5, 2016: Structure
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