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Paul Bolton

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https://www.readbyqxmd.com/read/28402869/the-use-of-composite-pulses-for-improving-deer-signal-at-94ghz
#1
Claire L Motion, Scott L Cassidy, Paul A S Cruickshank, Robert I Hunter, David R Bolton, Hassane El Mkami, Sabine Van Doorslaer, Janet E Lovett, Graham M Smith
The sensitivity of pulsed electron paramagnetic resonance (EPR) measurements on broad-line paramagnetic centers is often limited by the available excitation bandwidth. One way to increase excitation bandwidth is through the use of chirp or composite pulses. However, performance can be limited by cavity or detection bandwidth, which in commercial systems is typically 100-200MHz. Here we demonstrate in a 94GHz spectrometer, with >800MHz system bandwidth, an increase in signal and modulation depth in a 4-pulse DEER experiment through use of composite rather than rectangular π pulses...
May 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28334554/rapid-establishment-of-the-european-bank-for-induced-pluripotent-stem-cells-ebisc-the-hot-start-experience
#2
Paul A De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, Stefanie Seltmann, Johannes Dewender, Sascha Reimann, Glyn Stacey, Orla O'Shea, Charlotte Chapman, Lyn Healy, Heiko Zimmermann, Bryan Bolton, Trisha Rawat, Isobel Atkin, Anna Veiga, Bernd Kuebler, Blanca Miranda Serano, Tomo Saric, Jürgen Hescheler, Oliver Brüstle, Michael Peitz, Cornelia Thiele, Niels Geijsen, Bjørn Holst, Christian Clausen, Majlinda Lako, Lyle Armstrong, Shailesh K Gupta, Alexander J Kvist, Ryan Hicks, Anna Jonebring, Gabriella Brolén, Andreas Ebneth, Alfredo Cabrera-Socorro, Patrik Foerch, Martine Geraerts, Tina C Stummann, Shawn Harmon, Carol George, Ian Streeter, Laura Clarke, Helen Parkinson, Peter W Harrison, Adam Faulconbridge, Luca Cherubin, Tony Burdett, Cesar Trigueros, Minal J Patel, Christa Lucas, Barry Hardy, Rok Predan, Joh Dokler, Maja Brajnik, Oliver Keminer, Ole Pless, Philip Gribbon, Carsten Claussen, Annette Ringwald, Beate Kreisel, Aidan Courtney, Timothy E Allsopp
A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was surveyed to arrive at harmonised and publically accessible Standard Operations Procedures (SOPs) for tissue procurement, bio-sample tracking, iPSC expansion, cryopreservation, qualification and distribution to the research community...
April 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28245080/the-fate-of-verocytotoxigenic-escherichia-coli-c600%C3%AF-3538-%C3%AE-vtx2-cat-and-its-vtx2-prophage-during-grass-silage-preparation
#3
S Nyambe, C Burgess, P Whyte, P O'Kiely, D Bolton
AIMS: Silage is grass, preserved by fermentation and used as winter feed for cattle. The impact of a range of current grass silage preparation practices on the survival of Escherichia coli C600φ3538(Δvtx2 ::cat) and on the induction, release and infectivity of free phage were investigated. METHODS AND RESULTS: Wilted and fresh grass samples, from plots with and without slurry application, were ensiled with or without formic acid. Each treatment combination was inoculated with approximately 6 log10 CFU per g E...
February 28, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28163196/extraction-of-left-ventricular-ejection-fraction-information-from-various-types-of-clinical-reports
#4
Youngjun Kim, Jennifer H Garvin, Mary K Goldstein, Tammy S Hwang, Andrew Redd, Dan Bolton, Paul A Heidenreich, Stéphane M Meystre
Efforts to improve the treatment of congestive heart failure, a common and serious medical condition, include the use of quality measures to assess guideline-concordant care. The goal of this study is to identify left ventricular ejection fraction (LVEF) information from various types of clinical notes, and to then use this information for heart failure quality measurement. We analyzed the annotation differences between a new corpus of clinical notes from the Echocardiography, Radiology, and Text Integrated Utility package and other corpora annotated for natural language processing (NLP) research in the Department of Veterans Affairs...
February 2, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28077613/socioeconomic-deprivation-and-the-outcome-of-pulmonary-rehabilitation-in-england-and-wales
#5
Michael C Steiner, Derek Lowe, Katy Beckford, John Blakey, Charlotte E Bolton, Sarah Elkin, William D-C Man, C Michael Roberts, Louise Sewell, Paul Walker, Sally J Singh
BACKGROUND: Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many patients assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates with rates of completion of PR or the magnitude of clinical benefits bequeathed by PR. METHODS: PR services across England and Wales enrolled patients to the National PR audit in 2015. Deprivation was assessed using Index of Multiple Deprivation (IMD) derived from postcodes...
January 11, 2017: Thorax
https://www.readbyqxmd.com/read/28075157/visual-occlusion-during-minimally-invasive-surgery-a-contemporary-review-of-methods-to-reduce-laparoscopic-and-robotic-lens-fogging-and-other-sources-of-optical-loss
#6
Todd G Manning, Marlon Perera, Daniel Christidis, Ned Kinnear, Shannon McGrath, Richard O'Beirne, Paul Zotov, Damien Bolton, Nathan Lawrentschuk
BACKGROUND: Maintenance of optimal vision during minimally invasive surgery is crucial to maintaining operative awareness, efficiency, and safety. Hampered vision is commonly caused by laparoscopic lens fogging (LLF), which has prompted the development of various antifogging fluids and warming devices. However, limited comparative evidence exists in contemporary literature. Despite technologic advancements there remains no consensus as to superior methods to prevent LLF or restore visual acuity once LLF has occurred...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28067867/germline-brca2-mutations-drive-prostate-cancers-with-distinct-evolutionary-trajectories
#7
Renea A Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G Lawrence, Lee Timms, Declan G Murphy, Mark Frydenberg, Julia F Hopkins, Damien Bolton, David Clouston, John D McPherson, Theodorus van der Kwast, Paul C Boutros, Gail P Risbridger, Robert G Bristow
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes and methylomes of localized PCa from 14 carriers of deleterious germline BRCA2 mutations (BRCA2-mutant PCa). We show that BRCA2-mutant PCa harbour increased genomic instability and a mutational profile that more closely resembles metastastic than localized disease. BRCA2-mutant PCa shows genomic and epigenomic dysregulation of the MED12L/MED12 axis, which is frequently dysregulated in metastatic castration-resistant prostate cancer (mCRPC)...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28038402/the-fate-of-salmonella-typhimurium-and-escherichia-coli-o157-on-hot-boned-versus-conventionally-chilled-beef
#8
Rachael Reid, Séamus Fanning, Paul Whyte, Joe Kerry, Declan Bolton
This study investigated the fate of Salmonella Typhimurium and Escherichia coli O157 on hot boned versus conventionally chilled beef. Beef samples were individually inoculated with S. Typhimurium ATCC 14028, S. Typhimurium 844, E. coli O157 EDL 933 or E. coli T13. Half the samples were subject to the same time-temperature chilling profile used for conventionally chilling beef carcasses while the other half was subject to hot boned conditions. The surface pH (5.5) and aw (0.95 to 0.97) were stable. S. Typhimurium and E...
April 2017: Meat Science
https://www.readbyqxmd.com/read/27981595/an-investigation-of-the-effect-of-rapid-slurry-chilling-on-blown-pack-spoilage-of-vacuum-packaged-beef-primals
#9
R Reid, S Fanning, P Whyte, J Kerry, D Bolton
The aim of this study was to investigate if rapid slurry chilling would retard or prevent blown pack spoilage (BPS) of vacuum-packaged beef primals. Beef primals were inoculated with Clostridium estertheticum subspp. estertheticum (DSMZ 8809), C. estertheticum subspp. laramenise (DSMZ 14864) and C. gasigenes (DSMZ 12272), and vacuum-packaged with and without heat shrinkage (90°C for 3 s). These packs were then subjected to immediate chilling in an ice slurry or using conventional blast chilling systems and stored at 2°C for up to 100 days...
February 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27886641/comparison-of-hot-versus-cold-boning-of-beef-carcasses-on-bacterial-growth-and-the-risk-of-blown-pack-spoilage
#10
Rachael Reid, Séamus Fanning, Paul Whyte, Joe Kerry, Declan Bolton
Primals were prepared from beef Longissimus thoracis et lumborum (LTL), psoas major (PM), quadriceps femoris (QF) and semitendinosus (S) muscles from cold and hot boned carcasses, vacuum-packaged and stored for 42 or 100days at 2°C and 7°C. Storage temperature, carcass or primal surface temperature, pH and aw were monitored. Samples were taken periodically and tested for total viable count mesophilic (TVCm), TVC psychrophilic (TVCp), total Enterobacteriaceae count (TEC), presumptive Pseudomonas spp., lactic acid bacteria (LAB), Clostridium spp...
March 2017: Meat Science
https://www.readbyqxmd.com/read/27857003/mental-health-interventions-and-priorities-for-research-for-adult-survivors-of-torture-and-systematic-violence-a-review-of-the-literature
#11
REVIEW
William M Weiss, Ana M Ugueto, Zayan Mahmooth, Laura K Murray, Brian J Hall, Maya Nadison, Andrew Rasmussen, Jennifer S Lee, Andrea Vazzano, Judy Bass, Paul Bolton
This research describes the development and findings of a literature review and analysis meant to inform the international torture and trauma treatment community. The review focuses on interventions that have been used among populations affected by torture, based on a review of journals indexed in commonly used search engines. Work on the review began in September 2008 and continued to be updated until March 2014. In total, 88 studies of interventions for torture victims were identified. Studies ranged from randomized controlled trials utilizing evidence-based treatments to case studies employing non-structured, supportive therapies...
2016: Torture: Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture
https://www.readbyqxmd.com/read/27697169/the-microbiology-of-beef-carcasses-and-primals-during-chilling-and-commercial-storage
#12
Rachael Reid, Séamus Fanning, Paul Whyte, Joe Kerry, Roland Lindqvist, Zhongyi Yu, Declan Bolton
The primary objective of this study was to characterise (microbiology and physical parameters) beef carcasses and primals during chilled storage. A minor aim was to compare observed growth of key spoilage bacteria on carcasses with that predicted by ComBase and the Food Safety Spoilage Predictor (FSSP). Total viable count (TVC), total Enterobacteriacae count (TEC), Pseudomonas spp., lactic acid bacteria (LAB), Brochothrix thermosphacta and Clostridium spp. were monitored on beef carcasses (n = 30) and primals (n = 105) during chilled storage using EC Decision 2001/471/EC and ISO sampling/laboratory procedures...
February 2017: Food Microbiology
https://www.readbyqxmd.com/read/27670638/quantifying-full-phenological-event-distributions-reveals-simultaneous-advances-temporal-stability-and-delays-in-spring-and-autumn-migration-timing-in-long-distance-migratory-birds
#13
Will T S Miles, Mark Bolton, Peter Davis, Roy Dennis, Roger Broad, Iain Robertson, Nick J Riddiford, Paul V Harvey, Roger Riddington, Deryk N Shaw, David Parnaby, Jane M Reid
Phenological changes in key seasonally expressed life-history traits occurring across periods of climatic and environmental change can cause temporal mismatches between interacting species, and thereby impact population and community dynamics. However, studies quantifying long-term phenological changes have commonly only measured variation occurring in spring, measured as the first or mean dates on which focal traits or events were observed. Few studies have considered seasonally paired events spanning spring and autumn or tested the key assumption that single convenient metrics accurately capture entire event distributions...
September 27, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27647052/moderators-of-treatment-response-to-trauma-focused-cognitive-behavioral-therapy-among-youth-in-zambia
#14
Jeremy C Kane, Laura K Murray, Judith Cohen, Shannon Dorsey, Stephanie Skavenski van Wyk, Jennica Galloway Henderson, Mwiya Imasiku, John Mayeya, Paul Bolton
BACKGROUND: The effectiveness of mental health interventions such as trauma-focused cognitive behavioral therapy (TF-CBT) may vary by client, caregiver, and intervention-level variables, but few randomized trials in low- and middle-income countries (LMIC) have conducted moderation analyses to investigate these characteristics. This study explores moderating factors to TF-CBT treatment response among a sample of orphans and vulnerable children (OVC) in Zambia. METHODS: Data were obtained from a completed randomized trial of TF-CBT among 257 OVC in Zambia...
October 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27628482/ao-pelvic-fracture-classification-can-an-educational-package-improve-orthopaedic-registrar-performance
#15
John Au, Diana M Perriman, Claire Bolton, Liz Abbott, Teresa Neeman, Paul N Smith
BACKGROUND: The unstable pelvic fracture has been described as the 'killing fracture' because of the risk of significant vascular compromise. The ability to correctly classify pelvic fractures may therefore be crucial in optimizing patient outcomes. Pelvic fracture classification is difficult and previous research has indicated that ability is suboptimal in orthopaedic registrars. The objective of this study was to examine the efficacy of an educational package in improving orthopaedic registrars' ability to classify pelvic fractures...
December 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27609624/a-randomized-controlled-trial-of-a-trauma-informed-support-skills-and-psychoeducation-intervention-for-survivors-of-torture-and-related-trauma-in-kurdistan-northern-iraq
#16
Judith Bass, Sarah McIvor Murray, Thikra Ahmed Mohammed, Mary Bunn, William Gorman, Ahmed Mohammed Amin Ahmed, Laura Murray, Paul Bolton
Supportive counseling type interventions are frequently provided to meet the mental health needs of populations in emergency and post-conflicts contexts, but it has seldom been rigorously evaluated. Existing evaluations from low- and middle-income countries provide mixed evidence of effectiveness. While Iraqi Kurdistan experienced relative stability following the fall of Saddam Hussein's government, the population in the northern Dohuk region has continued to experience periodic violence due to conflicts with neighboring Turkey as well as more recent ISIS-associated violence...
September 28, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/27608488/ethical-erosion-in-newly-qualified-doctors-perceptions-of-empathy-decline
#17
Emily C Stratta, David M Riding, Paul Baker
OBJECTIVES: This study sought to understand whether UK Foundation doctors perceived the phenomena of ethical erosion and empathy decline during their initial period of clinical practice, and if so, why this occurred. METHODS: This qualitative study used semi-structured interviews with nine doctors in their first year of clinical practice at Royal Bolton Hospital, UK. Participants were invited to discuss the definition of empathy, how individuals acquire and maintain empathic ability, perceptions of ethical erosion in the self and others, and how clinical experiences have influenced their empathic ability...
September 6, 2016: International Journal of Medical Education
https://www.readbyqxmd.com/read/27553887/agricultural-anaerobic-digestion-power-plants-in-ireland-and-germany-policy-and-practice
#18
Agathe Auer, Nathan H Vande Burgt, Florence Abram, Gerald Barry, Owen Fenton, Bryan K Markey, Stephen Nolan, Karl Richards, Declan Bolton, Theo De Waal, Stephen V Gordon, Vincent O'Flaherty, Paul Whyte, Annetta Zintl
The process of anaerobic digestion (AD) is valued as a carbon-neutral energy source, while simultaneously treating organic waste, making it safer for disposal or use as a fertilizer on agricultural land. The AD process in many European nations, such as Germany, has grown from use of small, localized digesters to the operation of large-scale treatment facilities, which contribute significantly to national renewable energy quotas. However, these large AD plants are costly to run and demand intensive farming of energy crops for feedstock...
February 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27489565/mental-health-problems-among-conflict-affected-adults-in-grozny-chechnya-a-qualitative-study
#19
Amanda J Nguyen, Concetta Feo, Kyuri Idrisov, Giovanni Pintaldi, Annick Lenglet, Zalina Tsatsaeva, Paul Bolton, Judith Bass
BACKGROUND: A decade of conflict in Chechnya destroyed infrastructure and resulted in widespread exposure to violence. Amidst substantial reconstruction, periodic violence has contributed to an ongoing atmosphere of insecurity. We conducted a qualitative study to understand the mental health and psychosocial problems affecting adult Chechens in this context to inform development of assessment tools for an evaluation study related to individual counseling. METHODS: Data were collected in July 2014...
2016: Conflict and Health
https://www.readbyqxmd.com/read/27479822/whole-exome-sequencing-identifies-genetic-variants-in-inherited-thrombocytopenia-with-secondary-qualitative-function-defects
#20
Ben Johnson, Gillian C Lowe, Jane Futterer, Marie Lordkipanidzé, David MacDonald, Michael A Simpson, Isabel Sanchez-Guiú, Sian Drake, Danai Bem, Vincenzo Leo, Sarah J Fletcher, Ban Dawood, José Rivera, David Allsup, Tina Biss, Paula Hb Bolton-Maggs, Peter Collins, Nicola Curry, Charlotte Grimley, Beki James, Mike Makris, Jayashree Motwani, Sue Pavord, Katherine Talks, Jecko Thachil, Jonathan Wilde, Mike Williams, Paul Harrison, Paul Gissen, Stuart Mundell, Andrew Mumford, Martina E Daly, Steve P Watson, Neil V Morgan
Inherited thrombocytopenias are a heterogeneous group of disorders characterized by abnormally low platelet counts which can be associated with abnormal bleeding. Next-generation sequencing has previously been employed in these disorders for the confirmation of suspected genetic abnormalities, and more recently in the discovery of novel disease-causing genes. However its full potential has not yet been exploited. Over the past 6 years we have sequenced the exomes from 55 patients, including 37 index cases and 18 additional family members, all of whom were recruited to the UK Genotyping and Phenotyping of Platelets study...
October 2016: Haematologica
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