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James Griffith

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https://www.readbyqxmd.com/read/28919249/dosimetric-predictors-for-acute-esophagitis-during-radiation-therapy-for-lung-cancer-results-of-a-large-statewide-observational-study
#1
Peter Paximadis, Matthew Schipper, Martha Matuszak, Mary Feng, Shruti Jolly, Thomas Boike, Inga Grills, Larry Kestin, Benjamin Movsas, Kent Griffith, Gregory Gustafson, Jean Moran, Teamour Nurushev, Jeffrey Radawski, Lori Pierce, James Hayman
PURPOSE: The purpose of this study is to identify dosimetric variables that best predict for acute esophagitis in patients treated for locally advanced non-small cell lung cancer in a prospectively accrued statewide consortium. METHODS AND MATERIALS: Patients receiving definitive radiation therapy for stage II-III non-small cell lung cancer within the Michigan Radiation Oncology Quality Consortium were included in the analysis. Dose-volume histogram data were analyzed to determine absolute volumes (cc) receiving doses from 10 to 60 Gy (V10, V20, V30, V40, V50, and V60), as well as maximum dose to 2 cc (D2cc), mean dose (MD), and generalized equivalent uniform dose (gEUD)...
July 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28906549/developing-a-protocol-to-identify-and-prioritise-research-questions-for-psoriasis-a-james-lind-alliance-priority-setting-partnership
#2
R Majeed-Ariss, M McPhee, C Bundy, C E M Griffiths, H Young
BACKGROUND: Psoriasis affects over two million people in the UK. It confers a significant psychological and social impact on individuals and an associated high economic cost to the National Health Service. There are many unanswered questions about psoriasis. OBJECTIVES: 1. To develop a protocol in order to work with patients, families, carers and healthcare professionals to identify psoriasis uncertainties. 2. To agree by consensus a top ten list of psoriasis uncertainties...
September 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28903122/impact-of-ixekizumab-treatment-on-depressive-symptoms-and-systemic-inflammation-in-patients-with-moderate-to-severe-psoriasis-an-integrated-analysis-of-three-phase-3-clinical-studies
#3
Christopher E M Griffiths, Maurizio Fava, Andrew H Miller, James Russell, Susan G Ball, Wen Xu, Nayan Acharya, Mark Hyman Rapaport
BACKGROUND: Depression is a common comorbidity in psoriasis, and both conditions are associated with systemic inflammation. The efficacy of ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, was evaluated in patients with moderate-to-severe plaque psoriasis (psoriasis) and depressive symptoms that were at least moderately severe. METHODS: Data were integrated from 3 randomized, double-blind, controlled phase 3 trials. At baseline and week 12, depressive symptoms and inflammation were assessed by the 16-item Quick Inventory of Depressive Symptomology - Self-Report (QIDS-SR16) and by a high-sensitivity assay of serum C-reactive protein (hsCRP), respectively...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28891340/do-model-polymer-therapeutics-sufficiently-diffuse-through-articular-cartilage-to-be-a-viable-therapeutic-route
#4
Alison Powell, Bruce Caterson, Clare Hughes, Alison Paul, Craig James, Stephen Hopkins, Omar Mansour, Peter Griffiths
The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy, and is defined to a large part by the many and complex cellular biological and biochemical barriers such a construct must traverse. It is shown here that model dextrin conjugates are able to pass through a cartilaginous extracellular matrix into chondrocytes, with little perturbation of the matrix structure, indicating that targeting of potential therapeutics through a cartilaginous extracellular matrix should prove possible...
September 11, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28872272/understanding-low-sensitivity-of-community-based-hiv-rapid-testing-experiences-from-the-hptn-071-popart-trial-in-zambia-and-south-africa
#5
Peter Bock, Comfort Phiri, Estelle Piwowar-Manning, Barry Kosloff, Nomtha Mandla, Alicia Young, Anelet James, Ab Schaap, Michelle Scheepers, Deborah Donnell, Sam Griffith, Wafaa El-Sadr, Kwame Shanaube, Nulda Beyers, Richard Hayes, Sarah Fidler, Helen Ayles
INTRODUCTION: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care testing (HIV-POCT) is necessary but requires rigorous quality assurance (QA). This study assessed the performance of community-wide HTS in Zambia and South Africa (SA) as part of the HPTN 071 (PopART) study and explores the impact of quality improvement interventions on HTS performance...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28864516/bovine-tb-in-the-pilot-badger-cull-zone-in-gloucestershire
#6
Roger Blowey, Carl Gray, James Griffiths, Jan Rowe
No abstract text is available yet for this article.
September 2, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28864405/ischemic-cardiac-events-following-treatment-of-the-internal-mammary-nodal-region-using-contemporary-radiation-planning-techniques
#7
Robert T Dess, Adam L Liss, Kent A Griffith, Robin B Marsh, Jean M Moran, Charles Mayo, Todd M Koelling, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: Regional nodal irradiation, including radiation therapy (RT) to the internal mammary node (IMN) region, improves oncologic outcomes in patients with node-positive breast cancer. Concern remains, however, given the proximity of the IMNs to the heart and the association between cardiac RT exposure and toxicity. The objective of the study was to evaluate rates of ischemic cardiac events (ICEs) and associated risk with treatment of the IMN region. METHODS AND MATERIALS: The cardiac outcomes of 2126 patients treated with adjuvant breast RT or breast and nodal RT from 1984 to 2007 at a single institution were reviewed...
June 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28863076/histologic-correlates-of-clinical-and-endoscopic-severity-in-children-newly-diagnosed-with-ulcerative-colitis
#8
Brendan Boyle, Margaret H Collins, Zhu Wang, David Mack, Anne Griffiths, Cary Sauer, James Markowitz, Neal LeLeiko, David Keljo, Joel Rosh, Susan S Baker, Marian Pfefferkorn, Melvin Heyman, Ashish Patel, Robert Baldassano, Joshua Noe, Paul Rufo, Subra Kugathasan, Thomas Walters, Lee Denson, Jeffrey Hyams
To characterize rectal histology in an inception cohort of children newly diagnosed with ulcerative colitis (UC) and to explore its relationship with clinical indices of disease severity. The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) Study enrolled children 17 years of age and younger newly diagnosed with UC. Baseline rectal biopsies were evaluated for acute and chronic inflammation, eosinophilic inflammation (peak eosinophil count > 32 eosinophils/high powered field, eosinophilic cryptitis or abscesses), and architectural/nonarchitectural chronic changes...
August 31, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28843341/artificial-grammar-learning-in-vascular-and-progressive-non-fluent-aphasias
#9
Thomas E Cope, Benjamin Wilson, Holly Robson, Rebecca Drinkall, Lauren Dean, Manon Grube, P Simon Jones, Karalyn Patterson, Timothy D Griffiths, James B Rowe, Christopher I Petkov
Patients with non-fluent aphasias display impairments of expressive and receptive grammar. This has been attributed to deficits in processing configurational and hierarchical sequencing relationships. This hypothesis had not been formally tested. It was also controversial whether impairments are specific to language, or reflect domain general deficits in processing structured auditory sequences. Here we used an artificial grammar learning paradigm to compare the abilities of controls to participants with agrammatic aphasia of two different aetiologies: stroke and frontotemporal dementia...
August 24, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28825891/achilles-tendon-xanthomas-fat-water-separation-at-baseline-and-after-treatment
#10
James F Griffith, Miao Hu, David K W Yeung, Pei Guo, Sik Lok Lam, Fan Xiao, Defeng Wang, Brian Tomlinson
Purpose To investigate the fat-water content of Achilles tendon xanthomas at baseline and after treatment and to compare this assessment with that of ultrasonography (US) and other magnetic resonance (MR) imaging-based parameters. Materials and Methods Forty-eight Achilles tendons with clinically apparent xanthomas in 24 patients with familial hypercholesterolemia (FH) (six men, 18 women; mean age ± standard deviation, 58 years ± 9) were compared with 20 Achilles tendons in 10 control subjects without FH (two men, eight women; mean age, 62 years ± 7)...
August 21, 2017: Radiology
https://www.readbyqxmd.com/read/28819304/novel-stat-binding-elements-mediate-il-6-regulation-of-mmp-1-and-mmp-3
#11
Samuel J Cutler, James D Doecke, Ibtisam Ghazawi, Jinbo Yang, Lyn R Griffiths, Kevin J Spring, Stephen J Ralph, Albert S Mellick
Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are known to play a key role in regulating protease expression in cancer. Here we describe the identification of gamma-activated site (GAS)-like, signal transducer and activator of transcription (STAT) binding elements (SBEs) within the proximal promoters of the MMP-1 and MMP-3 genes, which in association with AP-1 components (c-Fos or Jun), bind STAT-1 in a homodimer like complex (HDLC)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808792/using-natural-language-processing-of-free-text-radiology-reports-to-identify-type-1-modic-endplate-changes
#12
Hannu T Huhdanpaa, W Katherine Tan, Sean D Rundell, Pradeep Suri, Falgun H Chokshi, Bryan A Comstock, Patrick J Heagerty, Kathryn T James, Andrew L Avins, Srdjan S Nedeljkovic, David R Nerenz, David F Kallmes, Patrick H Luetmer, Karen J Sherman, Nancy L Organ, Brent Griffith, Curtis P Langlotz, David Carrell, Saeed Hassanpour, Jeffrey G Jarvik
Electronic medical record (EMR) systems provide easy access to radiology reports and offer great potential to support quality improvement efforts and clinical research. Harnessing the full potential of the EMR requires scalable approaches such as natural language processing (NLP) to convert text into variables used for evaluation or analysis. Our goal was to determine the feasibility of using NLP to identify patients with Type 1 Modic endplate changes using clinical reports of magnetic resonance (MR) imaging examinations of the spine...
August 14, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28805827/transcriptional-risk-scores-link-gwas-to-eqtls-and-predict-complications-in-crohn-s-disease
#13
Urko M Marigorta, Lee A Denson, Jeffrey S Hyams, Kajari Mondal, Jarod Prince, Thomas D Walters, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Joel R Rosh, David R Mack, Richard Kellermayer, Melvin B Heyman, Susan S Baker, Michael C Stephens, Robert N Baldassano, James F Markowitz, Mi-Ok Kim, Marla C Dubinsky, Judy Cho, Bruce J Aronow, Subra Kugathasan, Greg Gibson
Gene expression profiling can be used to uncover the mechanisms by which loci identified through genome-wide association studies (GWAS) contribute to pathology. Given that most GWAS hits are in putative regulatory regions and transcript abundance is physiologically closer to the phenotype of interest, we hypothesized that summation of risk-allele-associated gene expression, namely a transcriptional risk score (TRS), should provide accurate estimates of disease risk. We integrate summary-level GWAS and expression quantitative trait locus (eQTL) data with RNA-seq data from the RISK study, an inception cohort of pediatric Crohn's disease...
August 14, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28802313/aoac-smpr-%C3%A2-2017-010
#14
Prashant Ingle, Brad Barrett, Joseph M Betz, Clyde Don, Nour Eddine Es-Safi, James Griffiths, George Joseph, David C Kennedy, Elizabeth Mudge, Melissa Meaney Phillips, Tom Phillips, Lanette D Richards, Catherine A Rimmer, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, James Traub, Yanjun Zhang, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802312/aoac-smpr-%C3%A2-2017-009
#15
Prashant Ingle, Brad Barrett, Joseph M Betz, Clyde Don, Nour Eddine Es-Safi, James Griffiths, George Joseph, David C Kennedy, Elizabeth Mudge, Melissa Meaney Phillips, Tom Phillips, Lanette D Richards, Catherine A Rimmer, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, James Traub, Yanjun Zhang, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802311/aoac-smpr-%C3%A2-2015-016
#16
John Austad, Brad Barrett, Joseph M Betz, Carolyn Quarles Burdette, Clyde Don, Andy Erickson, James Griffiths, Jana B Hildreth, Prashant Ingle, Martha Jennens, David Ji, George Joseph, David C Kennedy, Elizabeth Mudge, Matthew Noestheden, Melissa Meaney Phillips, Curtis S Phinney, Mitzi Rettinger, Lanette D Richards, Catherine A Rimmer, Nandakumara Sarma, Berenice Sauza, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, John Szpylka, James Traub, Denise Lowe Walters, J P Woods, Jinchuan Yang, Seong-Jae Yoo, Troy Zhang, Weiguo Zhang, Yanjun Zhang, Joyce Zhu, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28801403/equipping-community-pharmacy-workers-as-agents-for-health-behaviour-change-developing-and-testing-a-theory-based-smoking-cessation-intervention
#17
Liz Steed, Ratna Sohanpal, Wai-Yee James, Carol Rivas, Sandra Jumbe, Angel Chater, Adam Todd, Elizabeth Edwards, Virginia Macneil, Fraser Macfarlane, Trisha Greenhalgh, Chris Griffiths, Sandra Eldridge, Stephanie Taylor, Robert Walton
OBJECTIVE: To develop a complex intervention for community pharmacy staff to promote uptake of smoking cessation services and to increase quit rates. DESIGN: Following the Medical Research Council framework, we used a mixed-methods approach to develop, pilot and then refine the intervention. METHODS: Phase I: We used information from qualitative studies in pharmacies, systematic literature reviews and the Capability, Opportunity, Motivation-Behaviour framework to inform design of the initial version of the intervention...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799909/inflammation-antibiotics-and-diet-as-environmental-stressors-of-the-gut-microbiome-in-pediatric-crohn-s-disease
#18
James D Lewis, Eric Z Chen, Robert N Baldassano, Anthony R Otley, Anne M Griffiths, Dale Lee, Kyle Bittinger, Aubrey Bailey, Elliot S Friedman, Christian Hoffmann, Lindsey Albenberg, Rohini Sinha, Charlene Compher, Erin Gilroy, Lisa Nessel, Amy Grant, Christel Chehoud, Hongzhe Li, Gary D Wu, Frederic D Bushman
No abstract text is available yet for this article.
August 9, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28776130/erratum-to-changes-in-dural-sac-caliber-with-standing-mri-improve-correlation-with-symptoms-of-lumbar-spinal-stenosis
#19
Yvonne Yan On Lau, Ryan Ka Lok Lee, James Francis Griffith, Carol Lai Yee Chan, Sheung Wai Law, Kin On Kwok
No abstract text is available yet for this article.
August 3, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28772310/development-and-initial-validation-of-a-consumer-questionnaire-to-predict-the-presence-of-ear-disease
#20
Samantha J Kleindienst, David A Zapala, Donald W Nielsen, James W Griffith, Dania Rishiq, Larry Lundy, Sumitrajit Dhar
Importance: The already large population of individuals with age- or noise-related hearing loss in the United States is increasing, yet hearing aids remain largely inaccessible. The recent decision by the US Food and Drug Administration to not enforce the medical examination prior to hearing aid fitting highlights the need to reengineer consumer protections when increasing accessibility. A self-administered tool to estimate ear disease risk would provide disease surveillance without posing an unreasonable barrier to hearing aid procurement...
August 3, 2017: JAMA Otolaryngology—Head & Neck Surgery
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