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James Griffith

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https://www.readbyqxmd.com/read/28805827/transcriptional-risk-scores-link-gwas-to-eqtls-and-predict-complications-in-crohn-s-disease
#1
Urko M Marigorta, Lee A Denson, Jeffrey S Hyams, Kajari Mondal, Jarod Prince, Thomas D Walters, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Joel R Rosh, David R Mack, Richard Kellermayer, Melvin B Heyman, Susan S Baker, Michael C Stephens, Robert N Baldassano, James F Markowitz, Mi-Ok Kim, Marla C Dubinsky, Judy Cho, Bruce J Aronow, Subra Kugathasan, Greg Gibson
Gene expression profiling can be used to uncover the mechanisms by which loci identified through genome-wide association studies (GWAS) contribute to pathology. Given that most GWAS hits are in putative regulatory regions and transcript abundance is physiologically closer to the phenotype of interest, we hypothesized that summation of risk-allele-associated gene expression, namely a transcriptional risk score (TRS), should provide accurate estimates of disease risk. We integrate summary-level GWAS and expression quantitative trait locus (eQTL) data with RNA-seq data from the RISK study, an inception cohort of pediatric Crohn's disease...
August 14, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28802313/aoac-smpr-%C3%A2-2017-010
#2
Prashant Ingle, Brad Barrett, Joseph M Betz, Clyde Don, Nour Eddine Es-Safi, James Griffiths, George Joseph, David C Kennedy, Elizabeth Mudge, Melissa Meaney Phillips, Tom Phillips, Lanette D Richards, Catherine A Rimmer, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, James Traub, Yanjun Zhang, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802312/aoac-smpr-%C3%A2-2017-009
#3
Prashant Ingle, Brad Barrett, Joseph M Betz, Clyde Don, Nour Eddine Es-Safi, James Griffiths, George Joseph, David C Kennedy, Elizabeth Mudge, Melissa Meaney Phillips, Tom Phillips, Lanette D Richards, Catherine A Rimmer, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, James Traub, Yanjun Zhang, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28802311/aoac-smpr-%C3%A2-2015-016
#4
John Austad, Brad Barrett, Joseph M Betz, Carolyn Quarles Burdette, Clyde Don, Andy Erickson, James Griffiths, Jana B Hildreth, Prashant Ingle, Martha Jennens, David Ji, George Joseph, David C Kennedy, Elizabeth Mudge, Matthew Noestheden, Melissa Meaney Phillips, Curtis S Phinney, Mitzi Rettinger, Lanette D Richards, Catherine A Rimmer, Nandakumara Sarma, Berenice Sauza, Brian T Schaneberg, Aniko M Solyom, Darryl M Sullivan, John Szpylka, James Traub, Denise Lowe Walters, J P Woods, Jinchuan Yang, Seong-Jae Yoo, Troy Zhang, Weiguo Zhang, Yanjun Zhang, Joyce Zhu, Garrett Zielinski, Scott G Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28801403/equipping-community-pharmacy-workers-as-agents-for-health-behaviour-change-developing-and-testing-a-theory-based-smoking-cessation-intervention
#5
Liz Steed, Ratna Sohanpal, Wai-Yee James, Carol Rivas, Sandra Jumbe, Angel Chater, Adam Todd, Elizabeth Edwards, Virginia Macneil, Fraser Macfarlane, Trisha Greenhalgh, Chris Griffiths, Sandra Eldridge, Stephanie Taylor, Robert Walton
OBJECTIVE: To develop a complex intervention for community pharmacy staff to promote uptake of smoking cessation services and to increase quit rates. DESIGN: Following the Medical Research Council framework, we used a mixed-methods approach to develop, pilot and then refine the intervention. METHODS: Phase I: We used information from qualitative studies in pharmacies, systematic literature reviews and the Capability, Opportunity, Motivation-Behaviour framework to inform design of the initial version of the intervention...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799909/inflammation-antibiotics-and-diet-as-environmental-stressors-of-the-gut-microbiome-in-pediatric-crohn-s-disease
#6
James D Lewis, Eric Z Chen, Robert N Baldassano, Anthony R Otley, Anne M Griffiths, Dale Lee, Kyle Bittinger, Aubrey Bailey, Elliot S Friedman, Christian Hoffmann, Lindsey Albenberg, Rohini Sinha, Charlene Compher, Erin Gilroy, Lisa Nessel, Amy Grant, Christel Chehoud, Hongzhe Li, Gary D Wu, Frederic D Bushman
No abstract text is available yet for this article.
August 9, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28776130/erratum-to-changes-in-dural-sac-caliber-with-standing-mri-improve-correlation-with-symptoms-of-lumbar-spinal-stenosis
#7
Yvonne Yan On Lau, Ryan Ka Lok Lee, James Francis Griffith, Carol Lai Yee Chan, Sheung Wai Law, Kin On Kwok
No abstract text is available yet for this article.
August 3, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28772310/development-and-initial-validation-of-a-consumer-questionnaire-to-predict-the-presence-of-ear-disease
#8
Samantha J Kleindienst, David A Zapala, Donald W Nielsen, James W Griffith, Dania Rishiq, Larry Lundy, Sumitrajit Dhar
Importance: The already large population of individuals with age- or noise-related hearing loss in the United States is increasing, yet hearing aids remain largely inaccessible. The recent decision by the US Food and Drug Administration to not enforce the medical examination prior to hearing aid fitting highlights the need to reengineer consumer protections when increasing accessibility. A self-administered tool to estimate ear disease risk would provide disease surveillance without posing an unreasonable barrier to hearing aid procurement...
August 3, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28767142/prognostic-significance-of-tumor-length-in-patients-receiving-esophagectomy-for-esophageal-cancer
#9
Alexander C Hollis, Lauren M Quinn, James Hodson, Emily Evans, James Plowright, Ruksana Begum, Harriet Mitchell, Mike T Hallissey, John L Whiting, Ewen A Griffiths
AIMS: We investigated the prognostic value of tumor length measurements acquired both from pre-operative imaging and post-operative pathology in esophageal cancer. METHODS: Tumor lengths were examined retrospectively for 389 esophagectomy patients with respect to Endoscopy, EUS (Endoscopic Ultrasound), CT and PET-CT, and pathology. Correlations between the measurements on the different approaches were assessed, and associations between tumor length and survival were analyzed...
August 2, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28765059/bing-neel-syndrome-bilateral-cavernous-sinus-lymphoma-causing-visual-failure
#10
Chengde Pham, James D Griffiths, Anthony Kam, Martin K Hunn
We report the case of a 68-year-old male with right eye vision loss secondary to a compressive optic neuropathy from Waldenstrom macroglobulinaemia relapse in both cavernous sinuses. Central nervous system involvement is extremely uncommon in lymphoplasmacytic lymphoma. Known as Bing-Neel syndrome, this has not been previously reported to present simultaneously in bilateral cavernous sinuses. We discuss the pathophysiology, diagnostic and neuroradiological features of Bing-Neel syndrome. In this case, there was marked clinical and radiological response to chemotherapy...
July 29, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28752229/hope-modules-brief-psychotherapeutic-interventions-to-counter-demoralization-from-daily-stressors-of-chronic-illness
#11
James L Griffith
No abstract text is available yet for this article.
July 27, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28747295/motivate-a-pretreatment-web-based-program-to-improve-attendance-at-uk-outpatient-services-among-adults-with-eating-disorders
#12
Sarah Muir, Ciarán Newell, Jess Griffiths, Kathy Walker, Holly Hooper, Sarah Thomas, Peter W Thomas, Jon Arcelus, James Day, Katherine M Appleton
BACKGROUND: In the UK, eating disorders affect upward of 725,000 people per year, and early assessment and treatment are important for patient outcomes. Around a third of adult outpatients in the UK who are referred to specialist eating disorder services do not attend, which could be related to patient factors related to ambivalence, fear, and a lack of confidence about change. This lack of engagement has a negative impact on the quality of life of patients and has implications for service costs...
July 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28734938/hepatitis-e-virus-infection-and-acute-non-traumatic-neurological-injury-a-prospective-multicentre-study
#13
Harry R Dalton, Jeroen J J van Eijk, Pascal Cintas, Richie G Madden, Catherine Jones, Glynn W Webb, Benjamin Norton, Julie Pique, Suzanne Lutgens, Nikki Devooght-Johnson, Kathy Woolson, John Baker, Maria Saunders, Liz Househam, James Griffiths, Florence Abravanel, Jacques Izopet, Nassim Kamar, Nens van Alfen, Baziel G M van Engelen, Jeremy G Hunter, Annemiek A van der Eijk, Richard P Bendall, Brendan N Mclean, Bart C Jacobs
BACKGROUND AND AIMS: HEV has been associated with a number of neurological syndromes, but causality has not yet been established. AIM: to explore the relationship between HEV and neurological illness by prospective HEV-testing of patients presenting with acute non-traumatic neurological injury. METHODS: 464 consecutive patients presenting to hospital with acute non-traumatic neurological illnesses were tested for HEV by serology and PCR from 4 centres in the UK, France and the Netherlands...
July 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28734864/reasons-for-seeking-clinical-care-for-lower-urinary-tract-symptoms-a-mixed-methods-study
#14
James W Griffith, Emily E Messersmith, Brenda W Gillespie, Jonathan B Wiseman, Kathryn E Flynn, Ziya Kirkali, John W Kusek, Tamara Bavendam, David Cella, Karl J Kreder, Jasmine J Nero, Maria E Corona, Catherine S Bradley, Kimberly S Kenton, Brian T Helfand, Robert M Merion, Kevin P Weinfurt
PURPOSE: The primary objective of this study was to evaluate reasons for seeking care among men and women with lower urinary tract symptoms (LUTS). METHODS: Participants were recruited from urology and urogynecology clinics, and the community. The sample was enriched with persons expected to have abnormal or diminished bladder sensations (e.g., participants with lower back surgery, participants aged 65+). In-person interviews were conducted, beginning with an open-ended assessment of urinary symptoms and associated bother, followed by more directed questions, including reasons for seeking or not seeking treatment...
July 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28723333/enhanced-prophylaxis-plus-antiretroviral-therapy-for-advanced-hiv-infection-in-africa
#15
RANDOMIZED CONTROLLED TRIAL
James Hakim, Victor Musiime, Alex J Szubert, Jane Mallewa, Abraham Siika, Clara Agutu, Simon Walker, Sarah L Pett, Mutsa Bwakura-Dangarembizi, Abbas Lugemwa, Symon Kaunda, Mercy Karoney, Godfrey Musoro, Sheila Kabahenda, Kusum Nathoo, Kathryn Maitland, Anna Griffiths, Margaret J Thomason, Cissy Kityo, Peter Mugyenyi, Andrew J Prendergast, A Sarah Walker, Diana M Gibb
BACKGROUND: In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%. METHODS: In this factorial open-label trial conducted in Uganda, Zimbabwe, Malawi, and Kenya, we enrolled HIV-infected adults and children 5 years of age or older who had not received previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter...
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28711096/an-elderly-woman-with-painful-annular-erythematous-plaques
#16
Ben J Friedman, James L Griffith, Marsha L Chaffins
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28705062/ankle-traction-during-mri-of-talar-dome-osteochondral-lesions
#17
Ryan Ka Lok Lee, James F Griffith, Eric K C Law, Alex W H Ng, David K W Yeung
OBJECTIVE: The objective of our study was to assess the impact of axial traction during MRI of talar dome osteochondral lesions using a small-FOV coil. SUBJECTS AND METHODS: A prospective study of 33 patients undergoing high-resolution MRI of the ankle using a microscopy coil with and without axial traction was performed. Two radiologists independently measured the tibiotalar joint space width and semiquantitatively graded intraarticular joint fluid dispersion, cartilage surface visibility of the osteochondral lesion, and cartilage surface visibility elsewhere in the tibiotalar joint before and after traction...
July 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28702785/changes-in-dural-sac-caliber-with-standing-mri-improve-correlation-with-symptoms-of-lumbar-spinal-stenosis
#18
Yvonne Yan On Lau, Ryan Ka Lok Lee, James Francis Griffith, Carol Lai Yee Chan, Sheung Wai Law, Kin On Kwok
PURPOSE: Weight bearing does alter the dimension of lumbar spinal canal, but no study has analyzed its clinical correlation. This study aims to evaluate whether the changes in dural sac cross-sectional area (DSCA) and sagittal anteroposterior (AP) diameter on standing magnetic resonance imaging (MRI) correlate better with clinical symptoms of lumbar spinal stenosis. METHODS: Seventy consecutive patients with neurogenic claudication were prospectively recruited to undergo a 0...
July 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28655055/deep-convolutional-neural-networks-for-classifying-head-and-neck-cancer-using-hyperspectral-imaging
#19
Martin Halicek, Guolan Lu, James V Little, Xu Wang, Mihir Patel, Christopher C Griffith, Mark W El-Deiry, Amy Y Chen, Baowei Fei
No abstract text is available yet for this article.
June 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28639551/facet-joint-injections-for-people-with-persistent-non-specific-low-back-pain-facet-injection-study-a-feasibility-study-for-a-randomised-controlled-trial
#20
David R Ellard, Martin Underwood, Felix Achana, James Hl Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu
BACKGROUND: The National Institute for Health and Care Excellence (NICE) 2009 guidelines for persistent low back pain (LBP) do not recommend the injection of therapeutic substances into the back as a treatment for LBP because of the absence of evidence for their effectiveness. This feasibility study aimed to provide a stable platform that could be used to evaluate a randomised controlled trial (RCT) on the clinical effectiveness and cost-effectiveness of intra-articular facet joint injections (FJIs) when added to normal care...
May 2017: Health Technology Assessment: HTA
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