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James Griffith

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https://www.readbyqxmd.com/read/27899037/a-comparison-of-hmgb1-concentrations-between-cerebrospinal-fluid-and-blood-in-patients-with-neurological-disease
#1
Lauren Elizabeth Walker, Michael Griffiths, Fiona McGill, Penelope Lewthwaite, Graeme John Sills, Andrea Jorgensen, Daniel James Antoine, Tom Solomon, Anthony Guy Marson, Munir Pirmohamed
AIMS: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, HMGB1, in different neurological conditions. METHODS: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension (IIH), 18 neurological infection/inflammation (NII) and 10 Rasmussen's encephalitis (RE)). RESULTS: Mean serum (± SD) HMGB1 levels were 1...
November 30, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27836847/human-oral-buccal-microbiomes-are-associated-with-farmworker-status-and-azinphos-methyl-agricultural-pesticide-exposure
#2
Ian B Stanaway, James C Wallace, Ali Shojaie, William C Griffith, Sungwoo Hong, Carly S Wilder, Foad H Green, Jesse Tsai, Misty Knight, Tomomi Workman, Eric M Vigoren, Jeffrey S McLean, Beti Thompson, Elaine M Faustman
: In a longitudinal agricultural community cohort sampling of 65 farmworker and 52 non-farmworker adults, we investigated agricultural pesticide exposure associated changes in the oral buccal microbiota. We found a seasonally persistent association between the detected blood concentration of the insecticide Azinphos-methyl and the taxonomic composition of the buccal swab oral microbiome. Blood and buccal samples were collected concurrently from individual subjects in two seasons, spring/summer 2005 and winter 2006...
November 11, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27826775/analysis-of-lesion-localisation-at-colonoscopy-outcomes-from-a-multi-centre-u-k-study
#3
Susan J Moug, Spyridon Fountas, Mark S Johnstone, Adam S Bryce, Andrew Renwick, Lindsey J Chisholm, Kathryn McCarthy, Amy Hung, Robert H Diament, John R McGregor, Myo Khine, James D Saldanha, Khurram Khan, Graham Mackay, E Fiona Leitch, Ruth F McKee, John H Anderson, Ben Griffiths, Alan Horgan, Sonia Lockwood, Carly Bisset, Richard Molloy, Mark Vella
BACKGROUND: Colonoscopy is currently the gold standard for detection of colorectal lesions, but may be limited in anatomically localising lesions. This audit aimed to determine the accuracy of colonoscopy lesion localisation, any subsequent changes in surgical management and any potentially influencing factors. METHODS: Patients undergoing colonoscopy prior to elective curative surgery for colorectal lesion/s were included from 8 registered U.K. sites (2012-2014)...
November 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27786253/synchronizing-stochastic-circadian-oscillators-in-single-cells-of-neurospora-crassa
#4
Zhaojie Deng, Sam Arsenault, Cristian Caranica, James Griffith, Taotao Zhu, Ahmad Al-Omari, Heinz-Bernd Schüttler, Jonathan Arnold, Leidong Mao
The synchronization of stochastic coupled oscillators is a central problem in physics and an emerging problem in biology, particularly in the context of circadian rhythms. Most measurements on the biological clock are made at the macroscopic level of millions of cells. Here measurements are made on the oscillators in single cells of the model fungal system, Neurospora crassa, with droplet microfluidics and the use of a fluorescent recorder hooked up to a promoter on a clock controlled gene-2 (ccg-2). The oscillators of individual cells are stochastic with a period near 21 hours (h), and using a stochastic clock network ensemble fitted by Markov Chain Monte Carlo implemented on general-purpose graphical processing units (or GPGPUs) we estimated that >94% of the variation in ccg-2 expression was stochastic (as opposed to experimental error)...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768831/repair-of-bone-erosion-in-rheumatoid-arthritis-by-denosumab-a-high-resolution-peripheral-quantitative-computed-tomography-study
#5
Jiang Yue, James F Griffith, Fan Xiao, Lin Shi, Defeng Wang, Jiayun Shen, Priscilla Wong, Edmund K Li, Martin Li, Tena K Li, Tracy Y Zhu, Vivian W Hung, Ling Qin, Lai-Shan Tam
Objective To compare the bone healing effects of denosumab and alendronate in female rheumatoid arthritis (RA) patients by high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods This is a post-hoc analysis of a randomized-controlled trial (NCT01770106). 40 patients were randomized in a 1:1 ratio to receive either subcutaneous denosumab (60mg) once or oral alendronate (70mg) weekly for 6 months. The size of individual bone erosions and the presence and extent of erosion-associated sclerosis (marginal osteosclerosis) were measured in the second metacarpal head of the non-dominant hand at baseline, 3 and 6 months...
October 21, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27758066/the-colour-of-paternity-extra-pair-paternity-in-the-wild-gouldian-finch-does-not-appear-to-be-driven-by-genetic-incompatibility-between-morphs
#6
P E Bolton, L A Rollins, J Brazill-Boast, K-W Kim, T Burke, S C Griffith
In socially monogamous species, individuals can use extra-pair paternity and offspring sex allocation as adaptive strategies to ameliorate costs of genetic incompatibility with their partner. Previous studies on domesticated Gouldian finches (Erythrura gouldiae) demonstrated a genetic incompatibility between head colour morphs, the effects of which are more severe in female offspring. Domesticated females use differential sex allocation, and extra-pair paternity with males of compatible head colour, to reduce fitness costs associated with incompatibility in mixed-morph pairings...
October 18, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27747584/economic-evaluation-of-timely-versus-delayed-use-of-tumor-necrosis-factor-inhibitors-for-treatment-of-psoriatic-arthritis-in-the-us
#7
Vibeke Strand, Elaine Husni, Jenny Griffith, Zheng-Yi Zhou, James Signorovitch, Arijit Ganguli
INTRODUCTION: The present study aimed to evaluate clinical outcomes and costs associated with timely versus delayed use of tumor necrosis factor inhibitors (TNFis) among patients with moderately to severely active psoriatic arthritis (PsA) with and without moderate/severe psoriasis (Ps) from a US payer's perspective. METHODS: An economic model evaluated PsA patients initially treated with a TNFi (timely TNFi use) or apremilast (delayed TNFi use). Patients without joint (American College of Rheumatology 20%, [ACR20]) improvement either switched TNFis or initiated one...
December 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27735823/a-novel-large-animal-model-of-acute-respiratory-distress-syndrome-induced-by-mitochondrial-products
#8
Pablo G Sanchez, Chetan Pasrija, Matthew J Mulligan, Mandheer Wadhwa, Diana L Pratt, Tieluo Li, James S Gammie, Zachary N Kon, Si M Pham, Bartley P Griffith
OBJECTIVE: We aimed to create a reproducible lung injury model utilizing injection of mitochondrial damage-associated molecular products. Our goal was to characterize the pathophysiologic response to damage-associated molecular pattern mediated organ injury. SUMMARY BACKGROUND DATA: There remain significant gaps in our understanding of acute respiratory distress syndrome, in part due to the lack of clinically applicable animal models of this disease. Animal models of noninfectious, tissue damage-induced lung injury are needed to understand the signals and responses associated with this injury...
October 4, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27727158/repurposing-treatments-to-enhance-innate-immunity-can-statins-improve-neutrophil-functions-and-clinical-outcomes-in-copd
#9
Georgia M Walton, James A Stockley, Diane Griffiths, Charandeep S Sadhra, Thomas Purvis, Elizabeth Sapey
Drug classes used in the treatment of Chronic Obstructive Pulmonary Disease (COPD) have not changed for many years, and none to date have shown disease-modifying activity. Statins are used to help reduce cardiovascular risk, which is high in many patients with COPD. Their use has been associated with improvements in some respiratory manifestations of disease and reduction in all-cause mortality, with greatest reductions seen in patients with the highest inflammatory burden. The mechanism for these effects is poorly understood...
October 11, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27725679/imaging-biomarker-roadmap-for-cancer-studies
#10
James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
October 11, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27708065/allergic-asthma-is-distinguished-by-sensitivity-of-allergen-specific-cd4-t-cells-and-airway-structural-cells-to-type-2-inflammation
#11
Josalyn L Cho, Morris F Ling, David C Adams, Lucas Faustino, Sabina A Islam, Roshi Afshar, Jason W Griffith, Robert S Harris, Aylwin Ng, Giorgia Radicioni, Amina A Ford, Andre K Han, Ramnik Xavier, William W Kwok, Richard Boucher, James J Moon, Daniel L Hamilos, Mehmet Kesimer, Melissa J Suter, Benjamin D Medoff, Andrew D Luster
Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) to determine whether there are differences in the airway immune response or airway structural cells that could drive the development of asthma...
October 5, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27689388/first-in-class-chemical-probes-against-poly-adp-ribose-glycohydrolase-parg-inhibit-dna-repair-with-differential-pharmacology-to-olaparib
#12
Dominic I James, Kate M Smith, Allan M Jordan, Emma E Fairweather, Louise A Griffiths, Nicola S Hamilton, James R Hitchin, Colin P Hutton, Stuart Jones, Paul Kelly, Alison E McGonagle, Helen Small, Alexandra I J Stowell, Julie Tucker, Ian D Waddell, Bohdan Waszkowycz, Donald J Ogilvie
The enzyme poly(ADP-ribose) glycohydrolase (PARG) performs a critical role in the repair of DNA single strand breaks (SSBs). However, a detailed understanding of its mechanism of action has been hampered by a lack of credible, cell-active chemical probes. Herein, we demonstrate inhibition of PARG with a small molecule, leading to poly(ADP-ribose) (PAR) chain persistence in intact cells. Moreover, we describe two advanced, and chemically distinct, cell-active tool compounds with convincing on-target pharmacology and selectivity...
October 12, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27684379/randomized-controlled-trials-to-define-viral-load-thresholds-for-cytomegalovirus-pre-emptive-therapy
#13
Paul D Griffiths, Emily Rothwell, Mohammed Raza, Stephanie Wilmore, Tomas Doyle, Mark Harber, James O'Beirne, Stephen Mackinnon, Gareth Jones, Douglas Thorburn, Frank Mattes, Gaia Nebbia, Sowsan Atabani, Colette Smith, Anna Stanton, Vincent C Emery
BACKGROUND: To help decide when to start and when to stop pre-emptive therapy for cytomegalovirus infection, we conducted two open-label randomized controlled trials in renal, liver and bone marrow transplant recipients in a single centre where pre-emptive therapy is indicated if viraemia exceeds 3000 genomes/ml (2520 IU/ml) of whole blood. METHODS: Patients with two consecutive viraemia episodes each below 3000 genomes/ml were randomized to continue monitoring or to immediate treatment (Part A)...
2016: PloS One
https://www.readbyqxmd.com/read/27679840/identifying-and-prioritizing-diseases-important-for-detection-in-adult-hearing-health-care
#14
Samantha J Kleindienst, Sumitrajit Dhar, Donald W Nielsen, James W Griffith, Larry B Lundy, Colin Driscoll, Brian Neff, Charles Beatty, David Barrs, David A Zapala
PURPOSE: The purpose of this research note is to identify and prioritize diseases important for detection in adult hearing health care delivery systems. METHOD: Through literature review and expert consultation, the authors identified 195 diseases likely to occur in adults complaining of hearing loss. Five neurotologists rated the importance of disease on 3 dimensions related to the necessity of detection prior to adult hearing aid fitting. RESULTS: Ratings of adverse health consequences, diagnostic difficulty, and presence of nonotologic symptoms associated with these diseases resulted in the identification of 104 diseases potentially important for detection prior to adult hearing aid fitting...
September 1, 2016: American Journal of Audiology
https://www.readbyqxmd.com/read/27671670/use-of-science-to-guide-city-planning-policy-and-practice-how-to-achieve-healthy-and-sustainable-future-cities
#15
James F Sallis, Fiona Bull, Ricky Burdett, Lawrence D Frank, Peter Griffiths, Billie Giles-Corti, Mark Stevenson
Land-use and transport policies contribute to worldwide epidemics of injuries and non-communicable diseases through traffic exposure, noise, air pollution, social isolation, low physical activity, and sedentary behaviours. Motorised transport is a major cause of the greenhouse gas emissions that are threatening human health. Urban and transport planning and urban design policies in many cities do not reflect the accumulating evidence that, if policies would take health effects into account, they could benefit a wide range of common health problems...
September 19, 2016: Lancet
https://www.readbyqxmd.com/read/27633679/morphological-and-functional-development-of-the-interbranchial-lymphoid-tissue-ilt-in-atlantic-salmon-salmo-salar-l
#16
Alf Seljenes Dalum, David James Griffiths, Elin Christine Valen, Karoline Skaar Amthor, Lars Austbø, Erling Olaf Koppang, Charles McLean Press, Agnar Kvellestad
The interbranchial lymphoid tissue (ILT) of Atlantic salmon originates from an embryological location that in higher vertebrates gives rise to both primary and secondary lymphoid tissues. Still much is unknown about the morphological and functional development of the ILT. In the present work a standardized method of organ volume determination was established to study its development in relation to its containing gill and the thymus. Based on morphological findings and gene transcription data, the ILT shows no signs of primary lymphoid function...
September 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27622693/a-smart-force-limiting-instrument-for-microsurgery-laboratory-and-in-vivo-validation
#17
Hani J Marcus, Christopher J Payne, Ahilan Kailaya-Vasa, Sara Griffiths, James Clark, Guang-Zhong Yang, Ara Darzi, Dipankar Nandi
Residents are required to learn a multitude of skills during their microsurgical training. One such skill is the judicious application of force when handling delicate tissue. An instrument has been developed that indicates to the surgeon when a force threshold has been exceeded by providing vibrotactile feedback. The objective of this study was to validate the use of this "smart" force-limiting instrument for microsurgery. A laboratory and an in vivo experiment were performed to evaluate the force-limiting instrument...
2016: PloS One
https://www.readbyqxmd.com/read/27610220/an-assay-to-measure-poly-adp-ribose-glycohydrolase-parg-activity-in-cells
#18
Dominic I James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D Waddell, Donald J Ogilvie
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule inhibition of PARG has been a goal for many years. To determine whether biochemical inhibitors of PARG are active in cells we have designed an immunofluorescence assay to detect nuclear PAR after DNA damage. This 384-well assay is suitable for medium throughput high-content screening and can detect cell-permeable inhibitors of PARG from nM to µM potency...
2016: F1000Research
https://www.readbyqxmd.com/read/27595324/persisting-positron-emission-tomography-lesion-activity-and-mycobacterium-tuberculosis-mrna-after-tuberculosis-cure
#19
Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov, Magdalena Kriel, Tran Van, Ray Y Chen, James Warwick, Laura E Via, Taeksun Song, Myungsun Lee, Gary Schoolnik, Gerard Tromp, David Alland, Clifton E Barry, Jill Winter, Gerhard Walzl, Lance Lucas, Gian van der Spuy, Kim Stanley, Lani Theart, Bronwyn Smith, Nelita Burger, Caroline G G Beltran, Elizna Maasdorp, Annare Ellmann, Hongjo Choi, Joonsung Joh, Lori E Dodd, Brian Allwood, Coenie Kogelenberg, Morné Vorster, Stephanie Griffith-Richards
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET-CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease...
October 2016: Nature Medicine
https://www.readbyqxmd.com/read/27591176/preoperative-risk-factors-for-conversion-from-laparoscopic-to-open-cholecystectomy-a-validated-risk-score-derived-from-a-prospective-u-k-database-of-8820-patients
#20
Robert P Sutcliffe, Marianne Hollyman, James Hodson, Glenn Bonney, Ravi S Vohra, Ewen A Griffiths
BACKGROUND: Laparoscopic cholecystectomy is commonly performed, and several factors increase the risk of open conversion, prolonging operating time and hospital stay. Preoperative stratification would improve consent, scheduling and identify appropriate training cases. The aim of this study was to develop a validated risk score for conversion for use in clinical practice. PATIENTS AND METHODS: Preoperative patient and disease-related variables were identified from a prospective cholecystectomy database (CholeS) of 8820 patients, divided into main and validation sets...
August 30, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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