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James Griffith

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https://www.readbyqxmd.com/read/28320831/interference-of-the-t-cell-and-antigen-presenting-cell-costimulatory-pathway-using-ctla4-ig-abatacept-prevents-staphylococcal-enterotoxin-b-pathology
#1
Sarah J C Whitfield, Chris Taylor, Jane E Risdall, Gareth D Griffiths, James T A Jones, E Diane Williamson, Sjoerd Rijpkema, Luisa Saraiva, Sandrine Vessillier, A Christopher Green, Alun J Carter
Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo. Exposure to the toxin can be lethal and cause significant pathology in humans. The lack of effective therapies for SEB exposure remains an area of concern, particularly in scenarios of acute mass casualties. We hypothesized that blockade of the T cell costimulatory signal by the CTLA4-Ig synthetic protein (abatacept) could prevent SEB-dependent pathology...
March 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28316756/photon-reabsorption-in-mixed-cspbcl3-cspbi3-perovskite-nanocrystal-films-for-light-emitting-diodes
#2
Nathaniel J L K Davis, Francisco J de la Peña, Maxim Tabachnyk, Johannes M Richter, Robin D Lamboll, Edward P Booker, Florencia Wisnivesky Rocca Rivarola, James T Griffiths, Caterina Ducati, S Matthew Menke, Felix Deschler, Neil C Greenham
Cesium lead halide nanocrystals, CsPbX3 (X = Cl, Br, I), exhibit photoluminescence quantum efficiencies approaching 100% without the core-shell structures usually used in conventional semiconductor nanocrystals. These high photoluminescence efficiencies make these crystals ideal candidates for light-emitting diodes (LEDs). However, because of the large surface area to volume ratio, halogen exchange between perovskite nanocrystals of different compositions occurs rapidly, which is one of the limiting factors for white-light applications requiring a mixture of different crystal compositions to achieve a broad emission spectrum...
February 23, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28284142/reach-scale-variation-surface-water-quality-in-a-reticular-canal-system-in-the-lower-yangtze-river-delta-region-china
#3
James Andrew Griffiths, Faith Ka Shun Chan, Fangfang Zhu, Vickie Wang, David Laurence Higgitt
The aim of this research was to assess the spatial and temporal distribution of surface water pollution within a reticular canal system typical of those found in the lower Yangtze River Delta (YRD). For this purpose, surface water quality data was collected from a drainage canal that bisected the southeast district of Ningbo Municipality (Zhejiang) from 2013 to 2015. The sampling transect was designed to represent the change in land-use from the agriculture dominated rural hinterland, to the predominantly urban city-centre...
March 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28277982/mapping-differential-cellular-protein-response-of-mouse-alveolar-epithelial-cells-to-multi-walled-carbon-nanotubes-as-a-function-of-atomic-layer-deposition-coating
#4
Gina M Hilton, Alexia J Taylor, Salik Hussain, Erinn C Dandley, Emily H Griffith, Stavros Garantziotis, Gregory N Parsons, James C Bonner, Michael S Bereman
Carbon nanotubes (CNTs), a prototypical engineered nanomaterial, have been increasingly manufactured for a variety of novel applications over the past two decades. However, since CNTs possess fiber-like shape and cause pulmonary fibrosis in rodents, there is concern that mass production of CNTs will lead to occupational exposure and associated pulmonary diseases. The aim of this study was to use contemporary proteomics to investigate the mechanisms of cellular response in E10 mouse alveolar epithelial cells in vitro after exposure to multi-walled CNTs (MWCNTs) that were functionalized by atomic layer deposition (ALD)...
March 13, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28260023/silencing-bmi1-radiosensitizes-human-breast-cancer-cells-by-inducing-dna-damage-and-autophagy
#5
James Griffith, Daniel Andrade, Meghna Mehta, William Berry, Doris M Benbrook, Natarajan Aravindan, Terence S Herman, Rajagopal Ramesh, Anupama Munshi
Overexpression of BMI1 in human cancer cells, a member of the polycomb group of repressive complexes, correlates with advanced stage of disease, aggressive clinico-pathological behavior, poor prognosis, and resistance to radiation and chemotherapy. Studies have shown that experimental reduction of BMI1 protein level in tumor cells results in inhibition of cell proliferation, induction of apoptosis and/or senescence, and increased susceptibility to cytotoxic agents and radiation therapy. Although a role for BMI1 in cancer progression and its importance as a molecular target for cancer therapy has been established, information on the impact of silencing BMI1 in triple-negative breast cancer (TNBC) and its consequence on radiotherapy have not been well studied...
February 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28259484/prediction-of-complicated-disease-course-for-children-newly-diagnosed-with-crohn-s-disease-a-multicentre-inception-cohort-study
#6
Subra Kugathasan, Lee A Denson, Thomas D Walters, Mi-Ok Kim, Urko M Marigorta, Melanie Schirmer, Kajari Mondal, Chunyan Liu, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Scott Snapper, Shervin Rabizadeh, Joel R Rosh, Jason M Shapiro, Stephen Guthery, David R Mack, Richard Kellermayer, Michael D Kappelman, Steven Steiner, Dedrick E Moulton, David Keljo, Stanley Cohen, Maria Oliva-Hemker, Melvin B Heyman, Anthony R Otley, Susan S Baker, Jonathan S Evans, Barbara S Kirschner, Ashish S Patel, David Ziring, Bruce C Trapnell, Francisco A Sylvester, Michael C Stephens, Robert N Baldassano, James F Markowitz, Judy Cho, Ramnik J Xavier, Curtis Huttenhower, Bruce J Aronow, Greg Gibson, Jeffrey S Hyams, Marla C Dubinsky
BACKGROUND: Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown. METHODS: We did a prospective inception cohort study of paediatric patients with newly diagnosed Crohn's disease at 28 sites in the USA and Canada. Genotypes, antimicrobial serologies, ileal gene expression, and ileal, rectal, and faecal microbiota were assessed...
March 1, 2017: Lancet
https://www.readbyqxmd.com/read/28196607/development-of-a-model-web-based-system-to-support-a-statewide-quality-consortium-in-radiation-oncology
#7
Jean M Moran, Mary Feng, Lisa A Benedetti, Robin Marsh, Kent A Griffith, Martha M Matuszak, Michael Hess, Matthew McMullen, Jennifer H Fisher, Teamour Nurushev, Margaret Grubb, Stephen Gardner, Daniel Nielsen, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: A database in which patient data are compiled allows analytic opportunities for continuous improvements in treatment quality and comparative effectiveness research. We describe the development of a novel, web-based system that supports the collection of complex radiation treatment planning information from centers that use diverse techniques, software, and hardware for radiation oncology care in a statewide quality collaborative, the Michigan Radiation Oncology Quality Consortium (MROQC)...
October 20, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28193515/infliximab-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#8
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates and of malignancy and HLH in pediatric patients with IBD exposed to infliximab compared with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from 2007 through 30 June 2016...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28181830/effect-of-traction-on-wrist-joint-space-and-cartilage-visibility-with-and-without-mr-arthrography
#9
Ryan K L Lee, James F Griffith, W K Tang, Alex W H Ng, David K W Yeung
OBJECTIVE: To compare the effect of traction during non-arthrographic and arthrographic MR examination of the wrist with regard to joint space width, joint fluid dispersion and cartilage surface visibility. METHODS: Prospective 3-T MRI study of 100 wrists in 96 patients. The first 50 wrists underwent MR arthrography first without traction and then with traction. The following 50 wrists underwent standard MR first without traction and then with traction. On these examinations, two radiologists independently measured (i) joint space width, semi-quantitatively graded (ii) joint fluid dispersion between opposing cartilage surfaces and (iii) articular cartilage surface visibility...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28174251/a-process-engineering-approach-to-increase-organoid-yield
#10
Natasha Arora, Jasmin Imran Alsous, Jacob W Guggenheim, Michael Mak, Jorge Munera, James M Wells, Roger D Kamm, H Harry Asada, Stanislav Y Shvartsman, Linda G Griffith
Temporal manipulation of the in vitro environment and growth factors can direct differentiation of human pluripotent stem cells into organoids, aggregates with multiple tissue-specific cell types and three-dimensional structure mimicking native organs. A mechanistic understanding of early organoid formation is essential for improving the robustness of these methods, which is necessary prior to use in drug development and regenerative medicine. We investigated intestinal organoid emergence, focusing on measurable parameters of hindgut spheroids, the intermediate step between definitive endoderm and mature organoids...
February 7, 2017: Development
https://www.readbyqxmd.com/read/28161533/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-patients-with-chronic-obstructive-pulmonary-disease-in-london-uk
#11
David A Jolliffe, Wai Yee James, Richard L Hooper, Neil C Barnes, Claire L Greiller, Kamrul Islam, Angshu Bhowmik, Peter M Timms, Raj K Rajakulasingam, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Robert T Walton, Christopher J Corrigan, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41-92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction...
February 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28160560/exosome-secretome-and-mediated-signaling-in-breast-cancer-patients-with-nontuberculous-mycobacterial-disease
#12
Julie V Philley, Anbarasu Kannan, David E Griffith, Megan S Devine, Jeana L Benwill, Richard J Wallace Jr, Barbara A Brown-Elliott, Foram Thakkar, Varsha Taskar, James G Fox, Ammar Alqaid, Hernaina Bains, Sudeep Gupta, Santanu Dasgupta
Bronchiectasis Nontuberculous mycobacterium (NTMnb) infection is an emerging health problem in breast cancer (BCa) patients. We measured sera exosome proteome in BCa-NTMnb subjects and controls by Mass Spectroscopy. Extracellular matrix protein 1 (ECM1) was detected exclusively in the circulating exosomes of 82% of the BCa-NTMnb cases. Co-culture of ECM1+ exosomes with normal human mammary epithelial cells induced epithelial to mesenchymal transition accompanied by increased Vimentin/CDH1 expression ratio and Glutamate production...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28148635/high-dose-immunosuppressive-therapy-and-autologous-hct-for-relapsing-remitting-ms
#13
Richard A Nash, George J Hutton, Michael K Racke, Uday Popat, Steven M Devine, Kaitlyn C Steinmiller, Linda M Griffith, Paolo A Muraro, Harry Openshaw, Peter H Sayre, Olaf Stuve, Douglas L Arnold, Mark H Wener, George E Georges, Annette Wundes, George H Kraft, James D Bowen
OBJECTIVE: To evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization after high-dose immunosuppressive therapy (HDIT) and autologous hematopoietic cell transplantation (HCT). METHODS: High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT-MS) is a phase II clinical trial of HDIT/HCT for patients with relapsing-remitting (RR) MS who experienced relapses with disability progression (Expanded Disability Status Scale [EDSS] 3...
February 28, 2017: Neurology
https://www.readbyqxmd.com/read/28138155/corrigendum-mutations-in-snord118-cause-the-cerebral-microangiopathy-leukoencephalopathy-with-calcifications-and-cysts
#14
Emma M Jenkinson, Mathieu P Rodero, Paul R Kasher, Carolina Uggenti, Anthony Oojageer, Laurence C Goosey, Yoann Rose, Christopher J Kershaw, Jill E Urquhart, Simon G Williams, Sanjeev S Bhaskar, James O'Sullivan, Gabriela M Baerlocher, Monika Haubitz, Geraldine Aubert, Kristin W Barañano, Angela J Barnicoat, Roberta Battini, Andrea Berger, Edward M Blair, Janice E Brunstrom-Hernandez, Johannes A Buckard, David M Cassiman, Rosaline Caumes, Duccio M Cordelli, Liesbeth M De Waele, Alexander J Fay, Patrick Ferreira, Nicholas A Fletcher, Alan E Fryer, Himanshu Goel, Cheryl A Hemingway, Marco Henneke, Imelda Hughes, Rosalind J Jefferson, Ram Kumar, Lieven Lagae, Pierre G Landrieu, Charles M Lourenço, Timothy J Malpas, Sarju G Mehta, Imke Metz, Sakkubai Naidu, Katrin Õunap, Axel Panzer, Prab Prabhakar, Gerardine Quaghebeur, Raphael Schiffmann, Elliott H Sherr, Kanaga R Sinnathuray, Calvin Soh, Helen S Stewart, John Stone, Hilde Van Esch, Christine E G Van Mol, Adeline Vanderver, Emma L Wakeling, Andrea Whitney, Graham D Pavitt, Sam Griffiths-Jones, Gillian I Rice, Patrick Revy, Marjo S van der Knaap, John H Livingston, Raymond T O'Keefe, Yanick J Crow
No abstract text is available yet for this article.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28138153/civic-is-a-community-knowledgebase-for-expert-crowdsourcing-the-clinical-interpretation-of-variants-in-cancer
#15
Malachi Griffith, Nicholas C Spies, Kilannin Krysiak, Joshua F McMichael, Adam C Coffman, Arpad M Danos, Benjamin J Ainscough, Cody A Ramirez, Damian T Rieke, Lynzey Kujan, Erica K Barnell, Alex H Wagner, Zachary L Skidmore, Amber Wollam, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Yan-Yang Feng, Nakul M Shah, Melika Bonakdar, Lee Trani, Matthew Matlock, Avinash Ramu, Katie M Campbell, Gregory C Spies, Aaron P Graubert, Karthik Gangavarapu, James M Eldred, David E Larson, Jason R Walker, Benjamin M Good, Chunlei Wu, Andrew I Su, Rodrigo Dienstmann, Adam A Margolin, David Tamborero, Nuria Lopez-Bigas, Steven J M Jones, Ron Bose, David H Spencer, Lukas D Wartman, Richard K Wilson, Elaine R Mardis, Obi L Griffith
No abstract text is available yet for this article.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28132889/mucosal-expression-of-type-2-and-type-17-immune-response-genes-distinguishes-ulcerative-colitis-from-colon-only-crohn-s-disease-in-treatment-na%C3%A3-ve-pediatric-patients
#16
Michael J Rosen, Rebekah Karns, Jefferson E Vallance, Ramona Bezold, Amanda Waddell, Margaret H Collins, Yael Haberman, Phillip Minar, Robert N Baldassano, Jeffrey S Hyams, Susan S Baker, Richard Kellermayer, Joshua D Noe, Anne M Griffiths, Joel R Rosh, Wallace V Crandall, Melvin B Heyman, David R Mack, Michael D Kappelman, James Markowitz, Dedrick E Moulton, Neal S Leleiko, Thomas D Walters, Subra Kugathasan, Keith T Wilson, Simon P Hogan, Lee A Denson
BACKGROUND & AIMS: There is controversy over the role of the type 2 immune response in pathogenesis of ulcerative colitis (UC)-few data are available from treatment-naïve patients. We investigated whether genes associated with a type 2 immune response in the intestinal mucosa are upregulated in treatment-naïve pediatric patients with UC, compared to patients with Crohn's disease (CD)-associated colitis or without inflammatory bowel disease (IBD), and whether expression levels associate with clinical outcomes...
January 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28125559/o-011-low-dose-il-2-administration-expands-human-regulatory-t-cells-in-patients-with-uc-and-humanized-mice-and-protects-against-experimental-colitis
#17
Jeremy Goettel, Daniel Kotlarz, David Illig, James Canavan, Jessica Allegretti, Matthew Hamilton, Ryan Kelly, Alexandra Griffith, Madeline Carellas, Anastasia Nelina, Athos Bousvaros, Joshua Korzenik, Scott Snapper
BACKGROUND: Treg dysfunction or deficiency results in unopposed immune activation and autoimmunity. Interleukin-2 (IL-2) is critical for the expansion, suppressive function, and maintenance of Tregs. Although conventional T cells and NK cells respond to IL-2, Tregs are more sensitive to lower concentrations of IL-2 due to constitutive expression of CD25, the high affinity IL-2 receptor. Low-dose IL-2 therapies have shown to preferentially expand Tregs and ameliorate manifestations of graft versus host disease (Koreth et al...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28125557/o-009-long-ncrna-landscape-in-the-ileum-of-treatment-na%C3%A3-ve-early-onset-crohn-disease
#18
Yael Haberman, Marina Ben-Shoshan, Ayelet Di-Segni, Phillip Dexheimer, Tzipi Klein, Batya Weiss, Thomas Walters, Robert Baldassano, Joshua Noe, James Markowitz, Mel Heyman, Joel Rosh, Anne Griffiths, Wallace Crandall, Bruce Aronow, Yair Anikster, Jeffrey Hyams, Subra Kugathasan, Lee Denson
BACKGROUND: Long non-coding RNAs (lncRNA) regulate gene transcription and diverse cellular functions. We have recently reported a core inflammatory and metabolic ileal gene signature in treatment naïve pediatric Crohn Disease (CD), but the potential role of lncRNA was not known. We hypothesized that differences in ileal lncRNA would be associated with differences in protein-coding gene expression, suggesting a role for lncRNA in regulating those gene signatures. METHODS: Poly-A selected RNA-seq and Ensembl annotation were used to define differentially expressed ileal genes with false discovery rate correction of 0...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28110066/bioactive-nutrients-time-for-tolerable-upper-intake-levels-to-address-safety
#19
REVIEW
Allison A Yates, John W Erdman, Andrew Shao, Laurie C Dolan, James C Griffiths
There is increasing interest by consumers, researchers, and regulators into the roles that certain bioactive compounds, derived from plants and other natural sources, can play in health maintenance and promotion, and even prolonging a productive quality of life. Research has rapidly emerged suggesting that a wide range of compounds and mixtures in and from plants (such as fruits and vegetables, tea and cocoa) and animals (such as fish and probiotics) may exert substantial health benefits. There is interest in exploring the possibility of establishing recommended intakes or dietary guidance for certain bioactive substances to help educate consumers...
March 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28097016/smoking-treatment-optimisation-in-pharmacies-stop-a-cluster-randomised-pilot-trial-of-a-training-intervention
#20
V W Madurasinghe, Ratna Sohanpal, Wai James, Liz Steed, Sandra Eldridge, Sjc Taylor, C Griffiths, Robert Walton
BACKGROUND: UK government policy aims to strengthen the role of community pharmacies in health promotion. Thus, we conducted feasibility studies for an intervention to enhance delivery of the NHS Smoking Cessation Service. METHODS: The overall aims were to assess acceptability and feasibility of conducting the intervention in community pharmacies and piloting this with a cluster randomised trial. Specific objectives were (1) to estimate likely participation rates of pharmacies and stop smoking advisors, (2) to establish the potential impact of the training intervention on throughput and retention of smokers in smoking services, (3) to establish potential impact on smoking cessation outcomes, (4) to optimise logistics for conducting a cluster randomised trial in the next phase of the research programme and (5) to consider the feasibility of collecting pharmacy and service user data...
2017: Pilot and Feasibility Studies
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