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James Griffith

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https://www.readbyqxmd.com/read/28090445/population-reference-range-for-developmental-lumbar-spinal-canal-size
#1
James F Griffith, Junbin Huang, Sheung-Wai Law, Fan Xiao, Jason Chi Shun Leung, Defeng Wang, Lin Shi
BACKGROUND: Considerable variability exists in normal developmental lumbar spinal canal size. This impacts the likelihood of neural compromise. Spinal canal development is complete by 17 years. As diseases incurred thereafter do not knowingly affect the developmental size of the spinal canal, it is reasonable to use a selected population undergoing abdominopelvic computed tomography (CT) examination to determine developmental lumbar spinal canal size. METHODS: Study approval was granted by the Clinical Research Ethics Committee...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28074851/corrigendum-dynamics-and-genetics-of-a-disease-driven-species-decline-to-near-extinction-lessons-for-conservation
#2
M A Hudson, R P Young, J D'Urban Jackson, P Orozco-terWengel, L Martin, A James, M Sulton, G Garcia, R A Griffiths, R Thomas, C Magin, M W Bruford, A A Cunningham
No abstract text is available yet for this article.
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28031787/lac-1-and-lag-1-with-ras-1-affect-aging-and-the-biological-clock-in-neurospora-crassa
#3
John K Brunson, James Griffith, Daneisha Bowles, Mary E Case, Jonathan Arnold
Using an automated cell counting technique developed previously (Case et al., Ecology and Evolution 2014; 4: 3494), we explore the lifespan effects of lac-1, a ceramide synthase gene paralogous to lag-1 in Neurospora crassa in conjunction with the band bd (ras-1) gene. We find that the replicative lifespan of a lac-1(KO)bd double mutants is short, about one race tube cycle, and this double mutant lacks a strong ~21-hr clock cycle as shown by race tube and fluorometer analysis of fluorescent strains including lac-1(KO) ...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28006694/effects-and-moderators-of-exercise-on-quality-of-life-and-physical-function-in-patients-with-cancer-an-individual-patient-data-meta-analysis-of-34-rcts
#4
REVIEW
Laurien M Buffart, Joeri Kalter, Maike G Sweegers, Kerry S Courneya, Robert U Newton, Neil K Aaronson, Paul B Jacobsen, Anne M May, Daniel A Galvão, Mai J Chinapaw, Karen Steindorf, Melinda L Irwin, Martijn M Stuiver, Sandi Hayes, Kathleen A Griffith, Alejandro Lucia, Ilse Mesters, Ellen van Weert, Hans Knoop, Martine M Goedendorp, Nanette Mutrie, Amanda J Daley, Alex McConnachie, Martin Bohus, Lene Thorsen, Karl-Heinz Schulz, Camille E Short, Erica L James, Ron C Plotnikoff, Gill Arbane, Martina E Schmidt, Karin Potthoff, Marc van Beurden, Hester S Oldenburg, Gabe S Sonke, Wim H van Harten, Rachel Garrod, Kathryn H Schmitz, Kerri M Winters-Stone, Miranda J Velthuis, Dennis R Taaffe, Willem van Mechelen, Marie-José Kersten, Frans Nollet, Jennifer Wenzel, Joachim Wiskemann, Irma M Verdonck-de Leeuw, Johannes Brug
This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications...
January 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27986344/decreased-lung-perfusion-after-breast-chest-wall-irradiation-quantitative-results-from-a-prospective-clinical-trial
#5
Adam L Liss, Robin B Marsh, Nirav S Kapadia, Daniel L McShan, Virginia E Rogers, James M Balter, Jean M Moran, Kristy K Brock, Matt J Schipper, Reshma Jagsi, Kent A Griffith, Kevin R Flaherty, Kirk A Frey, Lori J Pierce
PURPOSE: To quantify lung perfusion changes after breast/chest wall radiation therapy (RT) using pre- and post-RT single photon emission computed tomography/computed tomography (SPECT/CT) attenuation-corrected perfusion scans; and correlate decreased perfusion with adjuvant RT dose for breast cancer in a prospective clinical trial. METHODS AND MATERIALS: As part of an institutional review board-approved trial studying the impact of RT technique on lung function in node-positive breast cancer, patients received breast/chest wall and regional nodal irradiation including superior internal mammary node RT to 50 to 52...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27936082/three-molecular-markers-show-no-evidence-of-population-genetic-structure-in-the-gouldian-finch-erythrura-gouldiae
#6
Peri E Bolton, Andrea J West, Adam P A Cardilini, Jennalee A Clark, Kimberley L Maute, Sarah Legge, James Brazill-Boast, Simon C Griffith, Lee A Rollins
Assessment of genetic diversity and connectivity between regions can inform conservation managers about risk of inbreeding, potential for adaptation and where population boundaries lie. The Gouldian finch (Erythrura gouldiae) is a threatened species in northern Australia, occupying the savannah woodlands of the biogeographically complex monsoon tropics. We present the most comprehensive population genetic analysis of diversity and structure the Gouldian finch using 16 microsatellite markers, mitochondrial control region and 3,389 SNPs from genotyping-by-sequencing...
2016: PloS One
https://www.readbyqxmd.com/read/27934657/the-importance-of-quality-specifications-in-safety-assessments-of-amino-acids-the-cases-of-l-tryptophan-and-l-citrulline
#7
REVIEW
Hellen A Oketch-Rabah, Amy L Roe, Bill J Gurley, James C Griffiths, Gabriel I Giancaspro
The increasing consumption of amino acids from a wide variety of sources, including dietary supplements, natural health products, medical foods, infant formulas, athletic and work-out products, herbal medicines, and other national and international categories of nutritional and functional food products, increases the exposure to amino acids to amounts far beyond those normally obtained from the diet, thereby necessitating appropriate and robust safety assessments of these ingredients. Safety assessments of amino acids, similar to all food constituents, largely rely on the establishment of an upper limit [Tolerable Upper Intake Level (UL)] considered to be a guide for avoiding high intake, above which adverse or toxic effects might occur...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27933113/a-study-of-the-optical-and-polarisation-properties-of-ingan-gan-multiple-quantum-wells-grown-on-a-plane-and-m-plane-gan-substrates
#8
Dmytro Kundys, Danny Sutherland, Matthew J Davies, Fabrice Oehler, James Griffiths, Philip Dawson, Menno J Kappers, Colin J Humphreys, Stefan Schulz, Fengzai Tang, Rachel A Oliver
We report on a comparative study of the low temperature emission and polarisation properties of InGaN/GaN quantum wells grown on nonpolar ([Formula: see text]) a-plane and ([Formula: see text]) m-plane free-standing bulk GaN substrates where the In content varied from 0.14 to 0.28 in the m-plane series and 0.08 to 0.21 for the a-plane series. The low temperature photoluminescence spectra from both sets of samples are broad with full width at half maximum height increasing from 81 to 330 meV as the In fraction increases...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27899037/a-comparison-of-hmgb1-concentrations-between-cerebrospinal-fluid-and-blood-in-patients-with-neurological-disease
#9
Lauren Elizabeth Walker, Michael John Griffiths, Fiona McGill, Penelope Lewthwaite, Graeme John Sills, Andrea Jorgensen, Daniel James Antoine, Tom Solomon, Anthony Guy Marson, Munir Pirmohamed
AIMS: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions. METHODS: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen's encephalitis [RE]). RESULTS: Mean serum (± SD) HMGB1 levels were 1...
December 8, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27836847/human-oral-buccal-microbiomes-are-associated-with-farmworker-status-and-azinphos-methyl-agricultural-pesticide-exposure
#10
Ian B Stanaway, James C Wallace, Ali Shojaie, William C Griffith, Sungwoo Hong, Carly S Wilder, Foad H Green, Jesse Tsai, Misty Knight, Tomomi Workman, Eric M Vigoren, Jeffrey S McLean, Beti Thompson, Elaine M Faustman
: In a longitudinal agricultural community cohort sampling of 65 adult farmworkers and 52 adult nonfarmworkers, we investigated agricultural pesticide exposure-associated changes in the oral buccal microbiota. We found a seasonally persistent association between the detected blood concentration of the insecticide azinphos-methyl and the taxonomic composition of the buccal swab oral microbiome. Blood and buccal samples were collected concurrently from individual subjects in two seasons, spring/summer 2005 and winter 2006...
January 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27826775/analysis-of-lesion-localisation-at-colonoscopy-outcomes-from-a-multi-centre-u-k-study
#11
Susan J Moug, Spyridon Fountas, Mark S Johnstone, Adam S Bryce, Andrew Renwick, Lindsey J Chisholm, Kathryn McCarthy, Amy Hung, Robert H Diament, John R McGregor, Myo Khine, James D Saldanha, Khurram Khan, Graham Mackay, E Fiona Leitch, Ruth F McKee, John H Anderson, Ben Griffiths, Alan Horgan, Sonia Lockwood, Carly Bisset, Richard Molloy, Mark Vella
BACKGROUND: Colonoscopy is currently the gold standard for detection of colorectal lesions, but may be limited in anatomically localising lesions. This audit aimed to determine the accuracy of colonoscopy lesion localisation, any subsequent changes in surgical management and any potentially influencing factors. METHODS: Patients undergoing colonoscopy prior to elective curative surgery for colorectal lesion/s were included from 8 registered U.K. sites (2012-2014)...
November 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27786253/synchronizing-stochastic-circadian-oscillators-in-single-cells-of-neurospora-crassa
#12
Zhaojie Deng, Sam Arsenault, Cristian Caranica, James Griffith, Taotao Zhu, Ahmad Al-Omari, Heinz-Bernd Schüttler, Jonathan Arnold, Leidong Mao
The synchronization of stochastic coupled oscillators is a central problem in physics and an emerging problem in biology, particularly in the context of circadian rhythms. Most measurements on the biological clock are made at the macroscopic level of millions of cells. Here measurements are made on the oscillators in single cells of the model fungal system, Neurospora crassa, with droplet microfluidics and the use of a fluorescent recorder hooked up to a promoter on a clock controlled gene-2 (ccg-2). The oscillators of individual cells are stochastic with a period near 21 hours (h), and using a stochastic clock network ensemble fitted by Markov Chain Monte Carlo implemented on general-purpose graphical processing units (or GPGPUs) we estimated that >94% of the variation in ccg-2 expression was stochastic (as opposed to experimental error)...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768831/repair-of-bone-erosion-in-rheumatoid-arthritis-by-denosumab-a-high-resolution-peripheral-quantitative-computed-tomography-study
#13
Jiang Yue, James F Griffith, Fan Xiao, Lin Shi, Defeng Wang, Jiayun Shen, Priscilla Wong, Edmund K Li, Martin Li, Tena K Li, Tracy Y Zhu, Vivian W Hung, Ling Qin, Lai-Shan Tam
Objective To compare the bone healing effects of denosumab and alendronate in female rheumatoid arthritis (RA) patients by high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods This is a post-hoc analysis of a randomized-controlled trial (NCT01770106). 40 patients were randomized in a 1:1 ratio to receive either subcutaneous denosumab (60mg) once or oral alendronate (70mg) weekly for 6 months. The size of individual bone erosions and the presence and extent of erosion-associated sclerosis (marginal osteosclerosis) were measured in the second metacarpal head of the non-dominant hand at baseline, 3 and 6 months...
October 21, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27758066/the-colour-of-paternity-extra-pair-paternity-in-the-wild-gouldian-finch-does-not-appear-to-be-driven-by-genetic-incompatibility-between-morphs
#14
P E Bolton, L A Rollins, J Brazill-Boast, K-W Kim, T Burke, S C Griffith
In socially monogamous species, individuals can use extra-pair paternity and offspring sex allocation as adaptive strategies to ameliorate costs of genetic incompatibility with their partner. Previous studies on domesticated Gouldian finches (Erythrura gouldiae) demonstrated a genetic incompatibility between head colour morphs, the effects of which are more severe in female offspring. Domesticated females use differential sex allocation, and extra-pair paternity with males of compatible head colour, to reduce fitness costs associated with incompatibility in mixed-morph pairings...
October 18, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27747584/economic-evaluation-of-timely-versus-delayed-use-of-tumor-necrosis-factor-inhibitors-for-treatment-of-psoriatic-arthritis-in-the-us
#15
Vibeke Strand, Elaine Husni, Jenny Griffith, Zheng-Yi Zhou, James Signorovitch, Arijit Ganguli
INTRODUCTION: The present study aimed to evaluate clinical outcomes and costs associated with timely versus delayed use of tumor necrosis factor inhibitors (TNFis) among patients with moderately to severely active psoriatic arthritis (PsA) with and without moderate/severe psoriasis (Ps) from a US payer's perspective. METHODS: An economic model evaluated PsA patients initially treated with a TNFi (timely TNFi use) or apremilast (delayed TNFi use). Patients without joint (American College of Rheumatology 20%, [ACR20]) improvement either switched TNFis or initiated one...
December 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27735823/a-novel-large-animal-model-of-acute-respiratory-distress-syndrome-induced-by-mitochondrial-products
#16
Pablo G Sanchez, Chetan Pasrija, Matthew J Mulligan, Mandheer Wadhwa, Diana L Pratt, Tieluo Li, James S Gammie, Zachary N Kon, Si M Pham, Bartley P Griffith
OBJECTIVE: We aimed to create a reproducible lung injury model utilizing injection of mitochondrial damage-associated molecular products. Our goal was to characterize the pathophysiologic response to damage-associated molecular pattern mediated organ injury. SUMMARY BACKGROUND DATA: There remain significant gaps in our understanding of acute respiratory distress syndrome, in part due to the lack of clinically applicable animal models of this disease. Animal models of noninfectious, tissue damage-induced lung injury are needed to understand the signals and responses associated with this injury...
October 4, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27727158/repurposing-treatments-to-enhance-innate-immunity-can-statins-improve-neutrophil-functions-and-clinical-outcomes-in-copd
#17
Georgia M Walton, James A Stockley, Diane Griffiths, Charandeep S Sadhra, Thomas Purvis, Elizabeth Sapey
Drug classes used in the treatment of Chronic Obstructive Pulmonary Disease (COPD) have not changed for many years, and none to date have shown disease-modifying activity. Statins are used to help reduce cardiovascular risk, which is high in many patients with COPD. Their use has been associated with improvements in some respiratory manifestations of disease and reduction in all-cause mortality, with greatest reductions seen in patients with the highest inflammatory burden. The mechanism for these effects is poorly understood...
October 11, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27725679/imaging-biomarker-roadmap-for-cancer-studies
#18
James P B O'Connor, Eric O Aboagye, Judith E Adams, Hugo J W L Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff J M Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification...
October 11, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27708065/allergic-asthma-is-distinguished-by-sensitivity-of-allergen-specific-cd4-t-cells-and-airway-structural-cells-to-type-2-inflammation
#19
Josalyn L Cho, Morris F Ling, David C Adams, Lucas Faustino, Sabina A Islam, Roshi Afshar, Jason W Griffith, Robert S Harris, Aylwin Ng, Giorgia Radicioni, Amina A Ford, Andre K Han, Ramnik Xavier, William W Kwok, Richard Boucher, James J Moon, Daniel L Hamilos, Mehmet Kesimer, Melissa J Suter, Benjamin D Medoff, Andrew D Luster
Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) to determine whether there are differences in the airway immune response or airway structural cells that could drive the development of asthma...
October 5, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27689388/first-in-class-chemical-probes-against-poly-adp-ribose-glycohydrolase-parg-inhibit-dna-repair-with-differential-pharmacology-to-olaparib
#20
Dominic I James, Kate M Smith, Allan M Jordan, Emma E Fairweather, Louise A Griffiths, Nicola S Hamilton, James R Hitchin, Colin P Hutton, Stuart Jones, Paul Kelly, Alison E McGonagle, Helen Small, Alexandra I J Stowell, Julie Tucker, Ian D Waddell, Bohdan Waszkowycz, Donald J Ogilvie
The enzyme poly(ADP-ribose) glycohydrolase (PARG) performs a critical role in the repair of DNA single strand breaks (SSBs). However, a detailed understanding of its mechanism of action has been hampered by a lack of credible, cell-active chemical probes. Herein, we demonstrate inhibition of PARG with a small molecule, leading to poly(ADP-ribose) (PAR) chain persistence in intact cells. Moreover, we describe two advanced, and chemically distinct, cell-active tool compounds with convincing on-target pharmacology and selectivity...
November 18, 2016: ACS Chemical Biology
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