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https://www.readbyqxmd.com/read/27864668/unproven-therapies-for-diabetes-and-their-implications
#1
REVIEW
Jothydev Kesavadev, Banshi Saboo, Shaukat Sadikot, Ashok Kumar Das, Shashank Joshi, Rajeev Chawla, Hemant Thacker, Arun Shankar, Lakshmy Ramachandran, Sanjay Kalra
Diabetes is a chronic disease and is one of the leading causes of morbidity and mortality worldwide. Being an ancient disease, many individuals follow complementary and alternative medicinal (CAM) therapies for either the cure or prevention of the disease. The popularity of these practices among the general public is in no way a testimony to their safety and efficacy. Due to the possibility of undesirable interactions with conventional medicines, it is imperative that patients are asked about CAM use during patient assessment...
November 18, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27461338/home-enteral-nutrition-therapy-difficulties-satisfactions-and-support-needs-of-caregivers-assisting-older-patients
#2
Nikolina Jukic P, Cristina Gagliardi, Donata Fagnani, Claudia Venturini, Paolo Orlandoni
BACKGROUND & AIMS: The purpose of this study was to comprehend and describe the views, experiences and adaptations of caregivers who assist older patients treated with Home Enteral Nutrition. The objective was to gather empirical evidence to improve the delivery of Home Enteral Nutrition for old patients taking into account the caregivers' support needs. METHODS: A qualitative methodology with focus groups as data collection method was used to collect the testimonies of 30 informal and formal caregivers of older patients treated with Home Enteral Nutrition by the Clinical Nutrition Service of INRCA (Ancona) during 2014...
July 9, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27424423/-brca-mutations-from-angelina-jolie-to-specific-therapies
#3
Veronica Aedo Lopez, Athina Stravodimou, Sheila Unger, Lucien Perey, Khalil Zaman
While mutations in BRCA1 and BRCA2 are found in only a minority of breast cancer patients, their impact for those patients is important. It is a powerful risk factor for this disease with respectively 65% and 45% of the women developing breast cancer. It requires a specific screening program starting at age of 25 that includes magnetic resonance imaging and risk reduction measures such as bilateral mastectomy and oophorectomy can be proposed. The psychological impacts of the mutation and its implications are not negligible...
May 18, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27346664/behaviour-that-underpins-non-pathological-criminal-incapacity-and-automatism-toward-clarity-for-psychiatric-testimony
#4
Pierre Mauritz Joubert, Cornelius Werdie van Staden
Psychiatric expert testimony is challenging in cases of violence when the accused person submits a defence that he or she was so overwhelmed by emotions triggered by an upsetting event that his or her violent behaviour was an uncontrollable consequence of the emotions. This defence is usually presented in terms of an automatism particularly not attributed to a mental disorder. Clouding testimony in these cases is the various definitions of both automatism and mental disorder-definitions by which the jurisprudential distinction is made between a sane and an insane automatism, or pathological and non-pathological incapacity (NPCI)...
September 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27330026/healing-through-giving-testimony-an-empirical-study-with-sri-lankan-torture-survivors
#5
Teresa S Puvimanasinghe, Ian R Price
Sri Lanka has recently emerged from a three decade long civil war between government forces and the Liberation Tigers of Tamil Eelam. Behind the actual arena of conflict, forms of organised violence were often perpetrated on ordinary Sri Lankans who came into contact with law enforcement officials and other state authorities. The effects of these encounters on mental health, well-being, and community participation can be severe and long-lasting. Considering the generally poor availability of mental health services in many low-income countries, brief efficient interventions are required to enhance the lives of individuals and their families affected by torture, trauma, or displacement...
October 2016: Transcultural Psychiatry
https://www.readbyqxmd.com/read/27279455/social-media-patient-testimonials-in-implant-dentistry-information-or-misinformation
#6
Adrian Ho, Colman McGrath, Nikos Mattheos
OBJECTIVES: This study aims to assess the educational value of YouTube patient testimonial videos in implant dentistry and qualitatively analyse the themes mentioned. METHODS: Videos were sampled consecutively on YouTube, using the keywords "dental implant patients' testimonials experience," sorted "by relevance." Patient testimonials on dental implant treatment were examined. Inaudible or non-English videos were excluded. Four calibrated investigators scored the videos for educational content, using a matrix derived from the European Association for Osseointegration information booklet, and demographic details were recorded...
June 8, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27132280/chronic-myeloid-leukemia-reminiscences-and-dreams
#7
REVIEW
Tariq I Mughal, Jerald P Radich, Michael W Deininger, Jane F Apperley, Timothy P Hughes, Christine J Harrison, Carlo Gambacorti-Passerini, Giuseppe Saglio, Jorge Cortes, George Q Daley
With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards...
May 2016: Haematologica
https://www.readbyqxmd.com/read/27069080/biomarker-tests-for-molecularly-targeted-therapies-laying-the-foundation-and-fulfilling-the-dream
#8
Gary H Lyman, Harold L Moses
Precision medicine focuses on the management of individual patients on the basis of biomarkers and other distinguishing characteristics, with the overarching objective of improving clinical outcomes. The rapid proliferation of biomarker tests and targeted therapies has revolutionized patient care in a variety of serious disorders. Targeted cancer therapies interrupt oncogenic molecular pathways driven by mutations, overexpression, or translocation of specific genes. However, there is concern that the emergence of large-scale genomic data is exceeding our capacity to appropriately analyze and interpret the results...
June 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26988243/biosimilars-a-multidisciplinary-perspective
#9
Majed Khraishi, David Stead, Milan Lukas, Florian Scotte, Holger Schmid
A biosimilar is an officially regulated and approved copy of an originator biologic therapy. Improved affordability and consequent wider patient access compared with biologics are a significant appeal of biosimilars. Regulatory guidelines for biosimilar development and approval are rigorous and undergoing constant refinement. The process of licensing approval for all biosimilars requires demonstration of comparability in quality, efficacy, and safety between the biosimilar and reference (originator) product, which is undertaken in a stepwise procedure of nonclinical and clinical evaluation...
May 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26963178/improving-psychology-students-attitudes-toward-people-with-schizophrenia-a-quasi-randomized-controlled-study
#10
Lorenza Magliano, Angela Rinaldi, Regina Costanzo, Renata De Leo, Giustina Schioppa, Miriam Petrillo, John Read
Despite scientific evidence that the majority of people with schizophrenia (PWS) have personal histories of traumatic life events and adversities, their needs for psychological support often remain unmet. Poor availability of nonpharmacological therapies in schizophrenia may be partly because of professionals' attitudes toward people diagnosed with this disorder. As future health professionals, psychology students represent a target population for efforts to increase the probability that PWS will be offered effective psychological therapies...
2016: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/26418479/update-on-medical-and-regulatory-issues-pertaining-to-compounded-and-fda-approved-drugs-including-hormone-therapy
#11
REVIEW
JoAnn V Pinkerton, James H Pickar
OBJECTIVE: We review the historical regulation of drug compounding, concerns about widespread use of non-Food and Drug Admiistration (FDA)-approved compounded bioidentical hormone therapies (CBHTs), which do not have proper labeling and warnings, and anticipated impact of the 2013 Drug Quality and Security Act (DQSA) on compounding. METHODS: US government websites were searched for documents concerning drug compounding regulation and oversight from 1938 (passage of Federal Food, Drug, and Cosmetic Act [FDCA]) through 2014, including chronologies, Congressional testimony, FDA guidelines and enforcements, and reports...
February 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/26201257/nurses-as-therapeutic-agents-in-the-extreme-environment-of-the-desert%C3%A2-war-1940-44
#12
Jane Brooks
AIMS: The purpose of this article is to explore therapeutic nursing with combatants in the extreme environment of the desert in World War II. BACKGROUND: The notion of nursing as therapy gained credence in the 1990s and is currently experiencing resurgence, as nurses seek to find meaning in their work and improve patient care in the post-Francis environment. DESIGN: This discussion paper will use the hostile space of the desert war zone in World War II to explore nurses' therapeutic engagement with their combatant patients...
November 2015: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/26179129/turning-regenerative-medicine-breakthrough-ideas-and-innovations-into-commercial-products
#13
REVIEW
Yves Bayon, Alain A Vertès, Vincent Ronfard, Emily Culme-Seymour, Chris Mason, Paul Stroemer, Mustapha Najimi, Etienne Sokal, Clayton Wilson, Joe Barone, Rahul Aras, Andrea Chiesi
The TERMIS-Europe (EU) Industry committee intended to address the two main critical issues in the clinical/commercial translation of Advanced Therapeutic Medicine Products (ATMP): (1) entrepreneurial exploitation of breakthrough ideas and innovations, and (2) regulatory market approval. Since January 2012, more than 12,000 publications related to regenerative medicine and tissue engineering have been accepted for publications, reflecting the intense academic research activity in this field. The TERMIS-EU 2014 Industry Symposium provided a reflection on the management of innovation and technological breakthroughs in biotechnology first proposed to contextualize the key development milestones and constraints of allocation of financial resources, in the development life-cycle of radical innovation projects...
December 2015: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/25942755/%C3%AF-%C3%AF-relevance-of-animal-models-for-wound-healing
#14
Roberto Perez, Stephen C Davis
Animal models and in-vitro assays have become indispensable tools for researchers in nearly every scientific discipline. Although definitive studies, which are conducted on human subjects, are the final testimonial of product efficacy, such studies can present several practical, ethical, and moral concerns. In-vitro assays are extremely useful when examining the effect of agents on particular cell types or specific environmental factors that could be influential during repair or infection. Some of the attractive benefits of these studies include: 1) relatively inexpensive, 2) fast, 3) convenient, and 4) provide important information on their potential cell to cell function...
January 2008: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/25852124/unorthodox-alternative-therapies-marketed-to-treat-lyme-disease
#15
REVIEW
Paul M Lantos, Eugene D Shapiro, Paul G Auwaerter, Phillip J Baker, John J Halperin, Edward McSweegan, Gary P Wormser
BACKGROUND: Some patients with medically unexplained symptoms or alternative medical diagnoses suspect that they chronically suffer from the tick-borne infection Lyme disease. These patients are commonly targeted by providers of alternative therapies. This study was designed to identify and characterize the range of unorthodox alternative therapies advertised to patients with a diagnosis of Lyme disease. METHODS: Internet searches using the Google search engine were performed to identify the websites of clinics and services that marketed nonantimicrobial therapies for Lyme disease...
June 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/25732030/diagnosis-and-management-of-diabetes-and-the-relationship-of-dglucose-to-kidney-function
#16
REVIEW
Anil K Mandal, Linda Hiebert
This article reviews different glycemic parameters and is aimed to clarify the most dependable glycemic parameter that predicts renal preservation. Glycosylated hemoglobin (HbA1c) and fasting blood glucose (FBG) are the most commonly ordered tests for the diagnosis of diabetes and are also used to indicate prevention of microvascular complications associated with diabetes. Some experts have concluded that HbA1c remains the only test that can predict microvascular complications but HbA1c is misleading with anemia...
2015: Current Diabetes Reviews
https://www.readbyqxmd.com/read/25511727/narrative-exposure-therapy-an-evidence-based-treatment-for-multiple-and-complex-trauma
#17
Ruud A Jongedijk
Narrative exposure therapy (NET) is a recently developed, short-term treatment for patients with a posttraumatic stress disorder (PTSD) as a result of multiple trauma. NET can be applied very successfully in patients with complex trauma complaints (Jongedijk, 2014; Schauer, Neuner, & Elbert, 2011). An important feature of NET is that trauma processing is never an isolated event but is always embedded in the context of a traumatic event and in the life history as a whole. At the start, the lifeline is laid. The lifeline is made up of a rope, with flowers (happy events), stones (traumatic events), sometimes candles (grief), or recently also sticks for aggressive acts (NET for offenders; see Stenmark, Cuneyt Guzey, Elbert, & Holen, 2014)...
2014: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/25409939/-legal-aspects-of-spondylosis
#18
H Bratzke, P W Gaidzik
Prior to a medical intervention (and also when omitted) it is important to implement the prerequisites for medical treatment as formulated by the legislation during the last decades. Essential points are the timely and comprehensive clarification and informed consent of the patient on diagnosis, therapy, complications and aftercare. The case described here substantiates the essential points which must be considered with respect to operative activities in the interests of the patient as well as the treating physicians...
December 2014: Der Orthopäde
https://www.readbyqxmd.com/read/25284896/psychotherapy-and-moralising-rhetoric-in-galen-s-newly-discovered-avoiding-distress-peri-alypias
#19
Sophia Xenophontos
In this article, I examine Galen's credentials as an ethical philosopher on the basis of his recently discovered essay Avoiding Distress (Peri alypias). As compensation for the scholarly neglect from which Galen's ethics suffers, I argue that his moral agenda is an essential part of his philosophical discourse, one that situates him firmly within the tradition of practical ethics of the Roman period. Galen's engagement with Stoic psychotherapy and the Platonic-Aristotelian educational model affirms his ethical authority; on the other hand, his distinctive moralising features such as the autobiographical perspective of his narrative and the intimacy between author and addressee render his Avoiding Distress exceptional among other essays, Greek or Latin, treating anxiety...
October 2014: Medical History
https://www.readbyqxmd.com/read/25284892/-recharge-my-exhausted-batteries-overbeck-s-rejuvenator-patenting-and-public-medical-consumers-1924-37
#20
James F Stark
Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device - the Overbeck Rejuvenator - a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority...
October 2014: Medical History
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