keyword
MENU ▼
Read by QxMD icon Read
search

Combined Elements Therapy

keyword
https://www.readbyqxmd.com/read/28227837/progressive-abduction-loading-therapy-targeting-flexion-synergy-to-regain-reaching-function-in-chronic-stroke-preliminary-results-from-an-rct
#1
Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Stuart Traxel, Michael D Ellis, Carolina Carmona, Julius P A Dewald, Justin Drogos
Reaching function is impaired following stroke due to abnormal coupling of shoulder abduction and elbow flexion. This phenomenon is commonly referred to as flexion synergy, loss of independent joint control, or impaired joint individuation. We have been successful in treating individuals with chronic stroke with moderate to severe motor impairments through the employment of targeted rehabilitation robotics and identified progressive abduction loading as a key element to the rehabilitation of reaching. Here we expand upon the investigation of progressive abduction loading therapy by testing two variants of the exercise in a larger sample and including a 3-month follow-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220928/malt-combined-motor-and-language-therapy-tool-for-brain-injury-patients-using-kinect
#2
Maitreyee Wairagkar, Rachel McCrindle, Holly Robson, Lotte Meteyard, Malcom Sperrin, Andy Smith, Moyra Pugh
BACKGROUND: The functional connectivity and structural proximity of elements of the language and motor systems result in frequent co-morbidity post brain injury. Although rehabilitation services are becoming increasingly multidisciplinary and "integrated", treatment for language and motor functions often occurs in isolation. Thus, behavioural therapies which promote neural reorganisation do not reflect the high intersystem connectivity of the neurologically intact brain. As such, there is a pressing need for rehabilitation tools which better reflect and target the impaired cognitive networks...
February 21, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28209726/therapeutic-targeting-of-the-pathological-triad-of-extrasynaptic-nmda-receptor-signaling-in-neurodegenerations
#3
REVIEW
Hilmar Bading
Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation-transcription coupling caused by CREB (cyclic adenosine monophosphate-responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone deacetylases. Interdependency within the triad fuels an accelerating disease progression that culminates in failure of mitochondrial energy production and cell loss...
February 16, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28206750/synthetic-riboswitches-from-plug-and-pray-towards-plug-and-play
#4
Maja Etzel, Mario Mörl
In synthetic biology, metabolic engineering as well as gene therapy there is a strong demand for orthogonal or externally controlled regulation of gene expression. Here, RNA-based regulatory devices represent a promising emerging alternative to proteins, allowing a fast and direct control of gene expression, as no synthesis of regulatory proteins is required. Besides programmable ribozyme elements controlling mRNA stability, regulatory RNA structures in untranslated regions are highly interesting for engineering approaches...
February 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/28197626/kdm6a-and-kdm6b-altered-expression-in-malignant-pleural-mesothelioma
#5
Sian Cregan, Maeve Breslin, Gerard Roche, Sigrid Wennstedt, Lauren MacDonagh, Cinaria Albadri, Yun Gao, Kenneth J O'Byrne, Sinead Cuffe, Stephen P Finn, Steven G Gray
Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The current standard of care for patients suffering from MPM is a combination of cisplatin and pemetrexed (or alternatively cisplatin and raltitrexed). Most patients, however, die within 24 months of diagnosis. New therapies are therefore urgently required for this disease. Inflammation is thought to be a key element in the pathogenesis of MPM, and recently Kdm6 family members (Kdm6a and Kdm6b) have been identified as playing important roles in inflammatory processes...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28179601/regulation-of-ras-signaling-and-function-by-plasma-membrane-microdomains
#6
Lawrence E Goldfinger, James V Michael
Together H-, N- and KRAS mutations are major contributors to ~30% of all human cancers. Thus, Ras inhibition remains an important anti-cancer strategy. The molecular mechanisms of isotypic Ras oncogenesis are still not completely understood. Monopharmacological therapeutics have not been successful in the clinic. These disappointing outcomes have led to attempts to target elements downstream of Ras, mainly targeting either the Phosphatidylinositol 3-Kinase (PI3K) or Mitogen-Activated Protein Kinase (MAPK) pathways...
February 7, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28164122/conservative-nonhormonal-options-for-the-treatment-of-male-infertility-antibiotics-anti-inflammatory-drugs-and-antioxidants
#7
REVIEW
Aldo E Calogero, Rosita A Condorelli, Giorgio Ivan Russo, Sandro La Vignera
The nonhormonal medical treatment can be divided into empirical, when the cause has not been identified, and nonempirical, if the pathogenic mechanism causing male infertility can be solved or ameliorated. The empirical nonhormonal medical treatment has been proposed for patients with idiopathic or noncurable oligoasthenoteratozoospermia and for normozoospermic infertile patients. Anti-inflammatory, fibrinolytic, and antioxidant compounds, oligo elements, and vitamin supplementation may be prescribed. Infection, inflammation, and/or increased oxidative stress often require a specific treatment with antibiotics, anti-inflammatory drugs, and/or antioxidants...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28161546/evaluation-of-changes-in-promoters-use-of-ucoes-and-chain-order-to-improve-the-antibody-production-in-cho-cells
#8
Maria Del Refugio Rocha-Pizaña, Guadalupe Ascencio-Favela, Brenda Maribell Soto-García, Margarita de la Luz Martinez-Fierro, Mario Moisés Alvarez
Therapy with biopharmaceuticals, mainly recombinant antibodies, offers patients higher life expectancy and better life quality than pharmacologic therapy. Countries with the highest scientific development are investing in this kind of therapy, and this is why the optimization of the production of these recombinant proteins would lead to their higher production and lower costs of the final product. Modifications in the use of promoters, the use of recombination regions, and the change in the order of the chains, are some of the genetic engineering changes that can increase the production of recombinant antibodies...
February 2, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28148287/intraoperative-irradiation-precision-medicine-for-quality-cancer-control-promotion
#9
EDITORIAL
Felipe A Calvo
Intraoperative irradiation was implemented 4 decades ago, pioneering the efforts to improve precision in local cancer therapy by combining real-time surgical exploration/resection with high single dose radiotherapy (Gunderson et al., Intraoperative irradiation: techniques and results, 2011). Clinical and technical developments have led to very precise radiation dose deposit. The ability to deliver a very precise dose of radiation is an essential element of contemporary multidisciplinary individualized oncology...
February 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28134800/immune-modulation-by-androgen-deprivation-and-radiation-therapy-implications-for-prostate-cancer-immunotherapy
#10
REVIEW
Jennifer L Kalina, David S Neilson, Alexandra P Comber, Jennifer M Rauw, Abraham S Alexander, Joanna Vergidis, Julian J Lum
Prostate cancer patients often receive androgen deprivation therapy (ADT) in combination with radiation therapy (RT). Recent evidence suggests that both ADT and RT have immune modulatory properties. First, ADT can cause infiltration of lymphocytes into the prostate, although it remains unclear whether the influx of lymphocytes is beneficial, particularly with the advent of new classes of androgen blockers. Second, in rare cases, radiation can elicit immune responses that mediate regression of metastatic lesions lying outside the field of radiation, a phenomenon known as the abscopal response...
January 27, 2017: Cancers
https://www.readbyqxmd.com/read/28133516/evaluation-of-estrogenic-activity-of-extract-from-the-herbal-mixture-cynanchum-wilfordii-hemsley-phlomis-umbrosa-turczaninow-and-angelica-gigas-nakai
#11
Se Jong Kim, Sun Woo Jin, Gi-Ho Lee, Yong An Kim, Hye Gwang Jeong
Hormone replacement therapy (HRT) consists of highly effective prescription medications for treating menopausal symptoms; however, these agents have exhibited side effects including the risk of estrogen-induced carcinogenesis. Therefore, interest in phytotherapy-based materials as a natural source of alternatives to estrogen therapy has increased. However, some of these herbal medicines have been reported to increase the risk of estrogen-induced cancer. Herbal formulations composed of a combination of Cynanchum wilfordii Hemsley (CW), Phlomis umbrosa Turczaninow (PU), and Angelica gigas Nakai (AG) extracts (CPAE) have been used for treating menopausal symptoms...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28130159/tandem-application-of-ligand-based-virtual-screening-and-g4-oas-assay-to-identify-novel-g-quadruplex-targeting-chemotypes
#12
Domenica Musumeci, Jussara Amato, Pasquale Zizza, Chiara Platella, Sandro Cosconati, Chiara Cingolani, Annamaria Biroccio, Ettore Novellino, Antonio Randazzo, Concetta Giancola, Bruno Pagano, Daniela Montesarchio
BACKGROUND: G-quadruplex (G4) structures are key elements in the regulation of cancer cell proliferation and their targeting is deemed to be a promising strategy in anticancer therapy. METHODS: A tandem application of ligand-based virtual screening (VS) calculations together with the experimental G-quadruplex on Oligo Affinity Support (G4-OAS) assay was employed to discover novel G4-targeting compounds. The interaction of the selected compounds with the investigated G4 in solution was analysed through a series of biophysical techniques and their biological activity investigated by immunofluorescence and MTT assays...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28129106/a-synthetic-mammalian-therapeutic-gene-circuit-for-sensing-and-suppressing-inflammation
#13
Anže Smole, Duško Lainšček, Urban Bezeljak, Simon Horvat, Roman Jerala
Inflammation, which is a highly regulated host response against danger signals, may be harmful if it is excessive and deregulated. Ideally, anti-inflammatory therapy should autonomously commence as soon as possible after the onset of inflammation, should be controllable by a physician, and should not systemically block beneficial immune response in the long term. We describe a genetically encoded anti-inflammatory mammalian cell device based on a modular engineered genetic circuit comprising a sensor, an amplifier, a "thresholder" to restrict activation of a positive-feedback loop, a combination of advanced clinically used biopharmaceutical proteins, and orthogonal regulatory elements that linked modules into the functional device...
January 4, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28125901/onebac-2-0-sf9-cell-lines-for-production-of-aav1-aav2-and-aav8-vectors-with-minimal-encapsidation-of-foreign-dna
#14
Mario Mietzsch, Henrik Hering, Eva-Maria Hammer, Mavis Agbandje-McKenna, Sergei Zolotukhin, Regine Heilbronn
Recombinant adeno-associated viral (rAAV) vectors for human gene therapy require efficient and economical production methods to keep pace with the rapidly increasing clinical demand. In addition, the manufacturing process must ensure high vector quality and biological safety. The OneBac system offers easily scalable rAAV vector production in insect Sf9-derived AAV rep/cap-expressing producer cell lines infected with a single baculovirus that carries the rAAV backbone. For most AAV serotypes high burst sizes per cell were achieved, combined with high infectivity rates...
February 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28121069/a-stiff-extracellular-matrix-is-associated-with-malignancy-in-peripheral-neuroblastic-tumors
#15
Irene Tadeo, Ana P Berbegall, Samuel Navarro, Victoria Castel, Rosa Noguera
PURPOSE AND OBJECTIVE: Improved prognosis for patients with peripheral neuroblastic tumors (PNB) depends on enhanced pretreatment risk stratification combined with research into new therapeutic targets. This study investigated the potential contribution of extracellular matrix (ECM) elements toward this endeavor. METHODS: We characterized certain elements such as reticulin fibers, collagen type I fibers, and elastic fibers by digital pathology in almost 400 untreated PNB...
January 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28116455/-dermatophyte-current-situation
#16
REVIEW
P Mayser
Currently, a mycid is defined as hyperergic reaction that develops from a remote localized infection and in which no fungus is detectable. Criteria for a mycid caused by a dermatophyte (dermatophytid) are (1) proven dermatophytosis elsewhere, (2) no evidence for fungal elements in the lesions of the -id reaction, (3) initially often worsening of the lesions under therapy with highly potent systemic antimycotics, and (4) clearing after the dermatophytosis has been treated sufficiently. The most common dermatophytid is a symmetrical dyshidrotic mycid of the hands in connection with an often highly inflammatory mycotic infection of the feet especially by Trichophyton mentagrophytes...
January 23, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28115275/current-knowledge-and-priorities-for-future-research-in-late-effects-after-hematopoietic-cell-transplantation-for-inherited-bone-marrow-failure-syndromes-consensus-statement-from-the-second-pediatric-blood-and-marrow-transplant-consortium-international-conference
#17
REVIEW
Andrew C Dietz, Parinda A Mehta, Adrianna Vlachos, Sharon A Savage, Dorine Bresters, Jakub Tolar, Farid Boulad, Jean Hugues Dalle, Carmem Bonfim, Josu de la Fuente, Christine N Duncan, K Scott Baker, Michael A Pulsipher, Jeffrey M Lipton, John E Wagner, Blanche P Alter
Fanconi anemia (FA), dyskeratosis congenita (DC), and Diamond Blackfan anemia (DBA) are 3 of the most common inherited bone marrow failure syndromes (IBMFS), in which the hematologic manifestations can be cured with hematopoietic cell transplantation (HCT). Later in life, these patients face a variety of medical conditions, which may be a manifestation of underlying disease or due to pre-HCT therapy, the HCT, or a combination of all these elements. Very limited long-term follow-up data exist in these populations, with FA the only IBMFS that has specific published data...
January 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28113565/hypoxia-stress-response-pathways-modeling-and-targeted-therapy
#18
Sriram Vakulabaranam, Rajani Varghese, Jijayanagaram Venkatraj, Aniruddha Datta
Hypoxia is a consequence of the decrease in the oxygen reaching the tissues of the body. It is a prominent feature of most solid tumors and is known to promote malignant progression, metastatic capacity, resistance to chemotherapy and leads to poor patient prognosis. When a cell is under hypoxic stress, a cascade of cell signals are initiated through a family of transcription factors named as Hypoxia Inducible Factors (HIFs). During hypoxia, HIF stabilizes and enters the nucleus and binds to the DNA via the Hypoxia Response Element (HRE) and leads to the translation of downstream genes...
April 27, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28105952/movement-visualisation-in-virtual-reality-rehabilitation-of-the-lower-limb-a-systematic-review
#19
REVIEW
Luara Ferreira Dos Santos, Oliver Christ, Kedar Mate, Henning Schmidt, Jörg Krüger, Christian Dohle
BACKGROUND: Virtual reality (VR) based applications play an increasing role in motor rehabilitation. They provide an interactive and individualized environment in addition to increased motivation during motor tasks as well as facilitating motor learning through multimodal sensory information. Several previous studies have shown positive effect of VR-based treatments for lower extremity motor rehabilitation in neurological conditions, but the characteristics of these VR applications have not been systematically investigated...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28090811/antibacterial-combination-therapy-using-co-3-cu-2-zn-2-and-pd-2-complexes-their-calf-thymus-dna-binding-studies
#20
Fatemeh Khosravi, Hassan Mansouri-Torshizi
Four Co(III)-, Cu(II)-, Zn(II)- and Pd(II)- based potent antibacterial complexes of formula K3[Co(ox)3].3H2O (I), [Cu(bpy)2Cl]Cl.5H2O (II), [Zn(bpy)3]Cl2 (III) and [Pd(bpy)2](NO3)2 (IV) (where ox is oxalate and bpy is 2,2'-bipyridine) were synthesized. They were characterized by elemental analyses, molar conductance measurements, UV-Vis, FT-IR, (1)H NMR and (13)C NMR spectra. These metal complexes were ordered in three combination series of I+II, I+II+III and I+II+III+IV. Antibacterial activity was tested for each of these four metal complexes and their combinations against gram positive and gram negative bacteria...
January 16, 2017: Journal of Biomolecular Structure & Dynamics
keyword
keyword
70610
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"