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Combined Elements Therapy

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https://www.readbyqxmd.com/read/29691958/brain-based-treatment-a-new-approach-or-a-well-forgotten-old-one
#1
Vanya Matanova, Zlatomira Kostova, Martin Kolev
For a relatively long period of time, mental functioning was mainly associated with personal profile while brain functioning went by the wayside. After the 90s of the 20th century, or the so called "Decade of the Brain", today, contemporary specialists work on the boundary between fundamental science and medicine. This brings neuroscience, neuropsychology, psychiatry, and psychotherapy closer to each other. Today, we definitely know that brain structures are being built and altered thanks to experience...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29685012/evaluating-the-utility-of-autoantibodies-for-disease-activity-and-relapse-in-giant-cell-arteritis
#2
T Kuret, K Lakota, A Hočevar, B Burja, S Čučnik, S Sodin-Semrl
In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. enzyme-linked immunoassays and multiplex beadbased immunoassays, while semiquantitative assays contribute valuable data on isoforms, epitope mapping and cellular localization...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29670836/construction-and-development-of-a-cardiac-tissue-specific-and-hypoxia-inducible-expression-vector
#3
Shahrooz Ghaderi, Neda Alidadiani, Jafar Soleimani Rad, Hamid Reza Heidari, Nafi Dilaver, Behzad Mansoori, Reza Rhabarghazi, Rezayat Parvizi, Vahid Khaze Shahgoli, Behzad Baradaran
Purpose: Cardiovascular gene therapy is a sophisticated approach, thanks to the safety of vectors, stable transgene expression, delivery method, and different layers of the heart. To date, numerous expression vectors have been introduced in biotechnology and biopharmacy industries in relation to genetic manipulation. Despite the rapid growth of these modalities, they must be intelligently designed, addressing the cardiac-specific transgene expression and less side effects. Herein, we conducted a pilot project aiming to design a cardiac-specific hypoxia-inducible expression cassette...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29667598/a-random-phased-array-for-mr-guided-transcranial-ultrasound-neuromodulation-in-non-human-primates
#4
Vandiver Chaplin, Marshal A Phipps, Charles F Caskey
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29665355/combination-therapy-with-polydeoxyribonucleotide-and-proton-pump-inhibitor-enhances-therapeutic-effectiveness-for-gastric-ulcer-in-rats
#5
Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Chang-Ju Kim, Jin-Hee Han, In Taik Hong, Min Seop Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeon
AIMS: The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treatment can be enhanced. Thus, in order to improve the therapeutic effect on GU, we tried to develop combination therapy promoting regeneration in injured tissue besides suppressing gastric acid secretion. MAIN METHODS: Polydeoxyribonucleotide (PDRN) was selected to evaluate tissue regeneration, and pantoprazole was chosen as one of the PPIs...
April 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29658792/scandium-and-terbium-radionuclides-for-radiotheranostics-current-state-of-development-towards-clinical-application
#6
Cristina Müeller, Katharina A Domnanich, Christoph A Umbricht, Nicholas P van der Meulen
Currently, different radiometals are in use for imaging and therapy in nuclear medicine: 68 Ga and 111 In are examples of nuclides for positron emission tomography (PET) and single photon emission computed tomography (SPECT), respectively, while 177 Lu and 225 Ac are used for β- - and α-radionuclide therapy. The application of diagnostic and therapeutic radionuclides of the same element (radioisotopes) would utilize chemically-identical radiopharmaceuticals for imaging and subsequent treatment, thereby enabling the radiotheranostic concept...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29656075/3d-printed-scaffolds-with-bioactive-elements-induced-photothermal-effect-for-bone-tumor-therapy
#7
Yaqin Liu, Tao Li, Hongshi Ma, Dong Zhai, Cuijun Deng, Jinwu Wang, Shangjun Zhuo, Jiang Chang, Chengtie Wu
For treatment of bone tumor and regeneration of bone defects, the biomaterials should possess the ability to kill tumor cells and regenerate bone defect simultaneously. To date, there are a few biomaterials possessing such dual functions, the disadvantages, however, such as long-term toxicity and degradation, restrict their application. Although bioactive elements have been incorporated into biomaterials to improve their osteogenic activity, there is no report about elements-induced functional scaffolds for photothermal tumor therapy...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29628034/-non-pharmacological-interventions
#8
Manuel Nevado Rey
Non-pharmacological therapies are currently one of the cornerstones of the prevention of the possible causes of cognitive impairment. Among other topics, the present article discusses the importance of identifying and working with elements such as a person's life history, interests, values, beliefs, and personal tastes and preferences and of combining them with techniques with proven effectiveness.
June 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29622007/synergistic-effect-of-phytochemicals-on-cholesterol-metabolism-and-lipid-accumulation-in-hepg2-cells
#9
Ennian Leng, Yuan Xiao, Zhentao Mo, Yiqi Li, Yueyue Zhang, Xiaosi Deng, Min Zhou, Chaochao Zhou, Zengxuan He, Jingyi He, Lu Xiao, Junming Li, Wenna Li
BACKGROUND: Crocin (CRO), chlorogenic acid (CGA), geniposide (GEN), and quercetin (QUE) are all natural compounds with anti-obesity properties, in particular, hypolipidemic effects, which have been widely used for the treatment of obesity-related metabolic diseases. However, it is not yet known whether these compounds interact synergistically. Here, we investigated the effects and molecular mechanisms of CRO, CGA, GEN, QUE, and a combination of all four compounds (CCGQ), on lipid accumulation in human hepatoma (HepG2 cells)...
April 5, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29608263/revisiting-of-pd-nanoparticles-in-cancer-treatment-all-round-excellence-of-porous-pd-nanoplates-in-gene-thermo-combinational-therapy
#10
Seounghun Kang, Woojun Shin, Kyunglee Kang, Myung-Ho Choi, Young-Jin Kim, Young-Kwan Kim, Dal-Hee Min, Hongje Jang
Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd)...
April 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29607792/nutritional-strategies-to-prevent-gastrointestinal-toxicity-during-pelvic-radiotherapy
#11
Linda J Wedlake
Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. The aim of this review was to synthesise published evidence for the use of elemental formulae, low or modified fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the bowel from gastrointestinal side effects during long-course, radical pelvic radiotherapy...
April 2, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29605708/long-terminal-repeat-crispr-car-coupled-universal-t-cells-mediate-potent-anti-leukemic-effects
#12
Christos Georgiadis, Roland Preece, Lauren Nickolay, Aniekan Etuk, Anastasia Petrova, Dariusz Ladon, Alexandra Danyi, Neil Humphryes-Kirilov, Ayokunmi Ajetunmobi, Daesik Kim, Jin-Soo Kim, Waseem Qasim
Gene editing can be used to overcome allo-recognition, which otherwise limits allogeneic T cell therapies. Initial proof-of-concept applications have included generation of such "universal" T cells expressing chimeric antigen receptors (CARs) against CD19 target antigens combined with transient expression of DNA-targeting nucleases to disrupt the T cell receptor alpha constant chain (TRAC). Although relatively efficient, transgene expression and editing effects were unlinked, yields variable, and resulting T cell populations heterogeneous, complicating dosing strategies...
March 6, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29596721/substance-use-comorbidity-in-bipolar-disorder-a-qualitative-review-of-treatment-strategies-and-outcomes
#13
REVIEW
Alexandra K Gold, Michael W Otto, Thilo Deckersbach, Louisa G Sylvia, Andrew A Nierenberg, Gustavo Kinrys
BACKGROUND AND OBJECTIVES: Substance use disorders (SUDs) are present in up to 70% of patients with bipolar disorder (BD) and contribute to high rates of disability, morbidity, and treatment non-adherence. Despite this prevalence, few trials have investigated targeted psychosocial interventions for comorbid BD and SUDs. METHODS: Using PubMed and PsycINFO, we conducted a search of the literature up to January 2018 for psychosocial interventions targeted to patients with comorbid BD and SUDs...
April 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29593978/quantitative-assessments-of-mechanical-responses-upon-radial-extracorporeal-shock-wave-therapy
#14
Yajun Liu, Xiaodong Chen, Anyi Guo, Sijin Liu, Guoqing Hu
Although radial extracorporeal shock wave therapy (rESWT) has been widely used to treat orthopedic disorders with promising clinical results, rESWT largely relies on clinicians' personal experiences and arbitrary judgments, without knowing relationships between administration doses and effective doses at target sites. In fact, practitioners lack a general and reliable way to assess propagation and distribution of pressure waves inside biological tissues quantitatively. This study develops a methodology to combine experimental measurements and computational simulations to obtain pressure fields from rESWT through calibrating and validating computational models with experimental measurements...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29572783/post-progression-survival-following-second-line-chemotherapy-in-patients-with-advanced-pancreatic-cancer-previously-treated-with-gemcitabine-a-meta-analysis
#15
REVIEW
Akiyoshi Kasuga, Yasuo Hamamoto, Ayano Takeuchi, Naohiro Okano, Kazuhiro Togasaki, Yu Aoki, Takeshi Suzuki, Kenta Kawasaki, Kenro Hirata, Yasutaka Sukawa, Takanori Kanai, Hiromasa Takaishi
Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination therapy showed statistical heterogeneity for overall survival (OS) but not for progression-free survival (PFS). This study aimed to improve the understanding of the impact of PPS on OS in this setting. Methods Databases were searched to identify randomized controlled trials (RCTs) in the salvage setting...
March 23, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29568505/cutting-down-the-time-to-identify-challenging-tumor-therapeutic-targets-and-drug-combinations-using-synthetic-lethal-approaches
#16
REVIEW
John S Lazo
Cancer drug discoverers and developers are blessed and cursed with a plethora of drug targets in the tumor cells themselves and the surrounding stromal elements. This bounty of targets has, at least in part, inspired the rapid increase in the number of clinically available small-molecule, biological, and cellular therapies for solid and hematological malignancies. Among the most challenging questions in cancer therapeutics, especially for small molecules, is how to approach loss-of-function gene mutations or deletions that encode tumor suppressors...
2018: F1000Research
https://www.readbyqxmd.com/read/29544801/effect-of-hypotensive-therapy-combined-with-modified-diet-or-zinc-supplementation-on-biochemical-parameters-and-mineral-status-in-hypertensive-patients
#17
Joanna Suliburska, Katarzyna Skrypnik, Monika Szulińska, Justyna Kupsz, Paweł Bogdański
BACKGROUND: Hypotensive therapy leads to a number of trace elements metabolism disturbances. Zinc balance is frequently affected by antihypertensive treatment. AIM: To evaluate the effect of a hypotensive treatment, modified diet and zinc supplementation on mineral status and selected biochemical parameters in newly diagnosed hypertensive patients on monotherapy. METHODS: In the first stage, arterial hypertension in ninety-eight human subjects was diagnosed...
May 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29537628/a-pragmatic-approach-to-monitor-and-evaluate-implementation-and-impact-of-differentiated-art-delivery-for-global-and-national-stakeholders
#18
Peter D Ehrenkranz, Jesus Mg Calleja, Wafaa El-Sadr, Ade O Fakoya, Nathan Ford, Anna Grimsrud, Kate L Harris, Suzanne L Jed, Daniel Low-Beer, Sadhna V Patel, Miriam Rabkin, William John Reidy, Annette Reinisch, George K Siberry, Leigh A Tally, Isaac Zulu, Irum Zaidi
INTRODUCTION: The World Health Organization's (WHO) recommendation of "Treat All" has accelerated the call for differentiated antiretroviral therapy (ART) delivery, a method of care that efficiently uses limited resources to increase access to HIV treatment. WHO has further recommended that stable individuals on ART receive refills every 3 to 6 months and attend clinical visits every 3 to 6 months. However, there is not yet consensus on how to ensure that the quality of services is maintained as countries strive to meet these standards...
March 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29537384/characterization-and-evaluation-of-a-flexible-mri-receive-coil-array-for-radiation-therapy-mr-treatment-planning-using-highly-decoupled-rf-circuits
#19
Kiaran P McGee, Robert S Stormont, Scott A Lindsay, Victor Taracila, Dennis Savitskij, Fraser Robb, Robert Witte, Timothy Kaufmann, John Huston Iii, Stephen J Riederer, Eric Borisch, Phillip J Rossman
The growth in the use of magnetic resonance imaging (MRI) data for radiation therapy (RT) treatment planning has been facilitated by scanner hardware and software advances that have enabled RT patients to be imaged in treatment position while providing morphologic and functional assessment of tumor volumes and surrounding normal tissues. Despite these advances, manufacturers have been slow to develop radiofrequency (RF) coils that closely follow the contour of a RT patient undergoing MR imaging. Instead, relatively large form surface coil arrays have been adapted from diagnostic imaging...
March 14, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29536011/investigating-the-ketogenic-diet-as-treatment-for-primary-aggressive-brain-cancer-challenges-and-lessons-learned
#20
Kenneth A Schwartz, Mary Noel, Michele Nikolai, Howard T Chang
Survival of glioblastoma multiforme (GBM) with the current recommended treatment is poor. Reported median survivals are approximately 8-15 months. Based on recent publications from animal models, combining cancer drugs, radiation, and diet-metabolic treatments may be a new route to better survivals. To investigate this possibility, we have begun a clinical trial that has enrolled 15 subjects using a ketogenic diet (KD) as an addition to current standard treatments that include surgery, radiation therapy, and chemotherapy...
2018: Frontiers in Nutrition
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