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Combined Elements Therapy

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https://www.readbyqxmd.com/read/29904646/spatial-relationship-between-bone-formation-and-mechanical-stimulus-within-cortical-bone-combining-3d-fluorochrome-mapping-and-poroelastic-finite-element-modelling
#1
A Carrieroa, A F Pereirab, A J Wilson, S Castagno, B Javaheri, A A Pitsillides, M Marenzana, S J Shefelbine
Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is spatially controlled by the local mechanical environment in the murine tibia axial loading model (C57BL/6). We obtained 3D locations of new bone formation by performing 'slice and view' 3D fluorochrome mapping of the entire bone and compared these sites with the regions of high fluid velocity or strain energy density estimated using a finite element model, validated with ex-vivo bone surface strain map acquired ex-vivo using digital image correlation...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29904047/evaluation-of-independent-versus-integrated-effects-of-reciprocal-electrical-stimulation-and-botulinum-toxin-a-on-dynamic-limits-of-postural-stability-and-ankle-kinematics-in-spastic-diplegia-a-single-blinded-randomized-trial
#2
Ragab K Elnaggar, Mohammed F Elbanna
BACKGROUND: Combination of medical and physical therapy protocols are increasingly recommended for cerebral palsied children. However, the clinicians frequently choose between independent or integrated treatment delivery based on little empirical evidence. AIM: To analyze the independent versus the integrated effects of Reciprocal Electrical Stimulation (RES) and Botulinum Toxin-A (BoNT-A) in terms of dynamic limits of postural stability and ankle kinematics in spastic diplegia...
June 14, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29890024/advanced-photosensitizer-activation-strategies-for-smarter-photodynamic-therapy-beacons
#3
Benjamin M Luby, Connor D Walsh, Gang Zheng
Photodynamic therapy (PDT) is a clinical treatment in which a light-absorbing drug called a photosensitizer is combined with light and molecular oxygen to generate cytotoxic singlet oxygen. PDT provides additional tissue selectivity versus conventional chemotherapy in that singlet oxygen is generated only in areas with both accumulated PS and simultaneous illumination by a light source with sufficient irradiance and dose. Early photodynamic therapy beacons built on this concept by adding an analyte-responsive element that simultaneously "turns-on" PDT and fluorescence, providing both an additional layer of selectivity and real-time feedback of the PS's activation state...
June 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29889256/hybrid-therapy-for-metastatic-epidural-spinal-cord-compression-technique-for-separation-surgery-and-spine-radiosurgery
#4
Ori Barzilai, Ilya Laufer, Adam Robin, Ran Xu, Yoshiya Yamada, Mark H Bilsky
BACKGROUND: Despite major advances in radiation and systemic treatments, surgery remains a critical step in the multidisciplinary treatment of metastatic spinal cord tumors. OBJECTIVE: To describe the indications, rationale, and technique of "hybrid therapy" (separation surgery and concomitant spine stereotactic radiosurgery [SRS]) along with practical nuances. METHODS: Separation surgery describes a posterolateral approach for circumferential epidural decompression and stabilization...
June 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29880014/targeting-tumour-re-wiring-by-triple-blockade-of-mtorc1-epidermal-growth-factor-and-oestrogen-receptor-signalling-pathways-in-endocrine-resistant-breast-cancer
#5
Ricardo Ribas, Sunil Pancholi, Aradhana Rani, Eugene Schuster, Stephanie K Guest, Joanna Nikitorowicz-Buniak, Nikiana Simigdala, Allan Thornhill, Francesca Avogadri-Connors, Richard E Cutler, Alshad S Lalani, Mitch Dowsett, Stephen R Johnston, Lesley-Ann Martin
BACKGROUND: Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+ ) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth factor pathways, circumventing the need for steroid hormones. Previously, we reported the anti-proliferative effect of everolimus (RAD001-mTORC1 inhibitor) with endocrine therapy in resistance models; however, potential routes of escape from treatment via ERBB2/3 signalling were observed...
June 8, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29872381/at-home-transcranial-direct-current-stimulation-tdcs-with-telehealth-support-for-symptom-control-in-chronically-ill-patients-with-multiple-symptoms
#6
Alexa Riggs, Vaishali Patel, Bhaskar Paneri, Russell K Portenoy, Marom Bikson, Helena Knotkova
Transcranial direct current stimulation (tDCS) delivered in multiple sessions can reduce symptom burden, but access of chronically ill patients to tDCS studies is constrained by the burden of office-based tDCS administration. Expanded access to this therapy can be accomplished through the development of interventions that allow at-home tDCS applications. Objective: We describe the development and initial feasibility assessment of a novel intervention for the chronically ill that combines at-home tDCS with telehealth support...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29862344/bouldering-psychotherapy-reduces-depressive-symptoms-even-when-general-physical-activity-is-controlled-for-a-randomized-controlled-trial
#7
Eva-Maria Stelzer, Stephanie Book, Elmar Graessel, Benjamin Hofner, Johannes Kornhuber, Katharina Luttenberger
Background: Bouldering psychotherapy (BPT) combines psychotherapeutic elements with physical activity (PA). It might be effective for reducing symptoms of depression, but so far, no study has assessed individuals' levels of PA to control for whether positive effects on depression can also be found when adjusting for participants' levels of PA. This is important because PA itself has been proven effective in reducing depression and therefore might be an important variable to account for - especially in therapies using sport as one therapeutic mechanism...
March 2018: Heliyon
https://www.readbyqxmd.com/read/29862014/glass-half-empty-lessons-learned-about-gastroparesis
#8
REVIEW
Patrick McKenzie, Klaus Bielefeldt
Gastroparesis is defined as a combination of chronic dyspeptic symptoms and delayed emptying of a solid test meal. It remains a difficult-to-treat disorder with a significant impact on quality of life. Although gastroparesis is defined by delayed emptying, several important studies did not find a correlation between this biomarker and symptom severity or treatment success. Thus, some of the more recent trials explored strategies that ranged from antiemetics to antidepressants. Although dietary management showed benefit, most of the other interventions were barely superior to placebo or were not superior at all...
2018: F1000Research
https://www.readbyqxmd.com/read/29861061/vertical-root-fracture-in-buccal-roots-of-bifurcated-maxillary-premolars-from-condensation-of-gutta-percha
#9
Herzl Chai, Aviad Tamse
INTRODUCTION: Maxillary premolars are among the teeth most susceptible to vertical root fracture (VRF) from lateral condensation of gutta-percha. These teeth are distinguished by a complex anatomy of the buccal root including a large depression in the dentin wall facing the bifurcation. It is hypothesized that tooth sectioning coupled with 2-dimensional fracture analysis is instrumental in understanding VRF in such teeth. VRF was examined by tooth sectioning following the development of a fracture mechanics analysis to predict VRF in such roots...
June 1, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29860881/-rheumatological-manifestations-in-primary-immunodeficiency-diseases
#10
Melinda Zsuzsanna Szabó
Primary immune deficiencies (PIDs) are characterized by quantitative and/or functional abnormalities of the immune system elements. Bone and joint abnormalities are not rare in patients with immunodeficiencies. Joint manifestations, of which arthritis is the most common, occur mainly in humoral PIDs (X-linked agammaglobulinemia, common variable immunodeficiency, and IgA deficiency) and occasionally in defects of the phagocyte system (chronic granulomatous disease, glicogen storage diseases). Monoarthritis or oligoarthritis is the usual pattern, caused by Mycoplasma, Staphylococcus, Streptococcus, Pneumococcus or Haemophilus species...
June 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29851799/short-term-effects-of-minimally-invasive-dynamic-neutralization-system-for-the-treatment-of-lumbar-spinal-stenosis-an-observational-study
#11
Ji Tu, Wenbin Hua, Wentian Li, Wei Liu, Rongjin Luo, Shuai Li, Yukun Zhang, Liang Kang, Kun Wang, Yu Song, Shuahua Yang, Cao Yang
The aim of the study was to evaluate the safety and short-term effects of dynamic stabilization via minimally invasive system for degenerative lumbar spinal stenosis. Patients with degenerative lumbar spinal stenosis and treated with Transforaminal Lumbar Interbody Fusion via minimally invasive minimally system (mis-TLIF) were served as the control group.From April 2011 to March 2015, 47 patients (29 male, 18 female; mean age 47.6 [range, 26-52] years) with lumbar spinal stenosis were treated with decompression and excision of herniated disk via the minimally invasive system combined with the dynamic fixation technique, and 42 patients as control group with mis-TLIF...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29804914/electrical-impedance-imaging-of-human-muscle-at-the-microscopic-scale-using-a-multi-electrode-needle-device-a-simulation-study
#12
Seward B Rutkove, Hyeuknam Kwon, Maria Guasch, Jim S Wu, Benjamin Sanchez
OBJECTIVE: To use a standard modeling approach to evaluate the feasibility of imaging healthy and diseased skeletal muscle at the microscopic scale with a novel electrical impedance imaging (EII) needle. METHODS: We modeled an EII needle containing 16 impedance electrodes arranged circumferentially around the shaft of a non-conductive 19-gauge needle in 4 planes. We then combined the finite element method approach with a reconstruction algorithm to create imaging simulations of the electrical properties of the triceps brachii by localized intramuscular fat (as might be seen in any chronic neuromuscular disease) and by localized edema (as in inflammatory myositis or after direct muscle injury)...
May 15, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29804468/nucleolar-localization-of-hiv-1-rev-is-required-yet-insufficient-for-production-of-infectious-viral-particles
#13
Jerlisa Ann Arizala, Mayumi Takahashi, John C Burnett, Dominique L Ouellet, John J Rossi
Combination antiretroviral therapy (cART) fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs. An understudied phenomenon is the nucleolar localization of Rev phosphoprotein, which completes nucleocytoplasmic transport of unspliced/partially spliced HIV mRNA through multimerization with intronic cis-acting targets - the Rev-response element (RRE)...
May 26, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29799634/technical-note-harmonic-analysis-applied-to-mr-image-distortion-fields-specific-to-arbitrarily-shaped-volumes
#14
T Stanescu, D Jaffray
PURPOSE: Magnetic resonance imaging is expected to play a more important role in radiation therapy given the recent developments in MR-guided technologies. MR images need to consistently show high spatial accuracy to facilitate RT specific tasks such as treatment planning and in-room guidance. The present study investigates a new harmonic analysis method for the characterization of complex 3D fields derived from MR images affected by system-related distortions. METHODS: An interior Dirichlet problem based on solving the Laplace equation with boundary conditions (BCs) was formulated for the case of a 3D distortion field...
May 25, 2018: Medical Physics
https://www.readbyqxmd.com/read/29798737/a-new-music-therapy-engagement-scale-for-persons-with-dementia
#15
Jane Tan, Shiou-Liang Wee, Pei Shi Yeo, Juliet Choo, Michele Ritholz, Philip Yap
ABSTRACTObjectives:To develop and validate a new scale to assess music therapy engagement in persons with dementia (PWDs). DESIGN: A draft scale was derived from literature review and >2 years of qualitative recording of PWDs during music therapy. Content validity was attained through iterative consultations, trial sessions, and revisions. The final five-item Music Therapy Engagement scale for Dementia (MTED) assessed music and non-music related elements. Internal consistency and inter-rater reliability were assessed over 120 music therapy sessions...
May 25, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29796465/photo-induced-heat-generation-in-non-plasmonic-nanoantennas
#16
Stefano Danesi, Marco Gandolfi, Luca Carletti, Nicolò Bontempi, Costantino De Angelis, Francesco Banfi, Ivano Alessandri
Light-to-heat conversion in non-plasmonic, high refractive index nanoantennas is a key topic for many applications, including Raman sensing, laser writing, nanofabrication and photo-thermal therapy. However, heat generation and propagation in non-plasmonic antennas is increasingly debated and contradictory results have been reported so far. Here we report a finite element analysis of the steady-state temperature distribution and heat flow in SiO2/Si core/shell systems (silicon nanoshells) irradiated with different continuous wave lasers (λ = 532, 633 and 785 nm), under real working conditions...
June 6, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29794324/magnetic-responsive-cell-based-strategies-for-diagnostic-and-therapeutics
#17
Ana I Gonçalves, Margarida S Miranda, Márcia T Rodrigues, Rui Luis Reis, Manuela Gomes
The potential of magnetically assisted strategies within the remit of cell-based therapies is increasing and creates new opportunities in biomedical platforms and in the field of tissue engineering and regenerative medicine (TERM).
 Among the magnetic elements approached to build magnetically responsive strategies, superparamagnetic iron oxide nanoparticles (SPIONs) represent tunable and precise tools whose properties can be modelled for detection, diagnosis, targeting and therapy purposes. The most investigated clinical role of SPIONs is as contrast imaging agents for tracking and monitoring cells and tissues...
May 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29794249/quality-origins-and-limitations-of-common-therapeutic-drug-reference-intervals
#18
REVIEW
Christopher R McCudden
Therapeutic drug monitoring (TDM) is used to manage drugs with a narrow window between effective and toxic concentrations. TDM involves measuring blood concentrations of drugs to ensure effective therapy, avoid toxicity and monitor compliance. Common drugs for which TDM is used include aminoglycosides for infections, anticonvulsants to treat seizures, immunosuppressants for transplant patients and cardiac glycosides to regulate cardiac output and heart rate. An essential element of TDM is the provision of accurate and clinically relevant reference intervals...
June 27, 2018: Diagnosis
https://www.readbyqxmd.com/read/29785514/correlation-of-dose-with-toxicity-and-tumour-response-to-90-y-and-177-lu-prrt-provides-the-basis-for-optimization-through-individualized-treatment-planning
#19
REVIEW
Marta Cremonesi, Mahila Esmeralda Ferrari, Lisa Bodei, Carlo Chiesa, Anna Sarnelli, Cristina Garibaldi, Massimiliano Pacilio, Lidia Strigari, Paul Eugene Summers, Roberto Orecchia, Chiara Maria Grana, Francesca Botta
PURPOSE: Peptide receptor radionuclide therapy (PRRT) with 90 Y-labelled and 177 Lu-labelled peptides is an effective strategy for the treatment of metastatic/nonresectable neuroendocrine tumours (NETs). Dosimetry provides important information useful for optimizing PRRT with individualized regimens to reduce toxicity and increase tumour responses. However, this strategy is not applied in routine clinical practice, despite the fact that several dosimetric studies have demonstrated significant dose-effect correlations for normal organ toxicity and tumour response that can better guide therapy planning...
May 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29784052/the-effect-of-heart-failure-and-left-ventricular-assist-device-treatment-on-right-ventricular-mechanics-a-computational-study
#20
Jun I K Park, Aulia Khamas Heikhmakhtiar, Chang Hyun Kim, Yoo Seok Kim, Seong Wook Choi, Kwang Soup Song, Ki Moo Lim
BACKGROUND AND AIMS: Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model...
May 22, 2018: Biomedical Engineering Online
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