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https://www.readbyqxmd.com/read/29228673/inhibition-of-pressure-activated-cancer-cell-adhesion-by-fak-derived-peptides
#1
Bixi Zeng, Dinesh Devadoss, Shouye Wang, Emilie E Vomhof-DeKrey, Leslie A Kuhn, Marc D Basson
Forces within the surgical milieu or circulation activate cancer cell adhesion and potentiate metastasis through signaling requiring FAK-Akt1 interaction. Impeding FAK-Akt1 interaction might inhibit perioperative tumor dissemination, facilitating curative cancer surgery without global FAK or AKT inhibitor toxicity. Serial truncation and structurally designed mutants of FAK identified a seven amino acid, short helical structure within FAK that effectively competes with Akt1-FAK interaction. Adenoviral overexpression of this FAK-derived peptide inhibited pressure-induced FAK phosphorylation and AKT-FAK coimmunoprecipitation in human SW620 colon cancer cells briefly exposed to 15mmHg increased pressure, consistent with laparoscopic or post-surgical pressures...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29223633/effectiveness-of-irrigation-with-chlorhexidine-after-removal-of-mandibular-third-molars-a-randomised-controlled-trial
#2
H Cho, M C David, A J Lynham, E Hsu
To evaluate the effect of postoperative irrigation with chlorhexidine on inflammatory complications after the extraction of lower third molars under local anaesthesia, we recruited 100 patients to participate in a controlled, single-blind, randomised clinical trial. They were assigned to one of two groups: the intervention group (postoperative irrigation of the surgical site with chlorhexidine for seven days) or the control group (postoperative chlorhexidine mouth rinse for seven days). The primary outcome variables were pain, swelling, trismus, infection, and alveolar osteitis...
December 6, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29221840/a-multicenter-study-of-irrigation-and-debridement-in-total-knee-arthroplasty-periprosthetic-joint-infection-treatment-failure-is-high
#3
Kenneth L Urish, Andrew G Bullock, Alexander M Kreger, Neel B Shah, Kwonho Jeong, Scott D Rothenberger
BACKGROUND: In total knee arthroplasty (TKA) periprosthetic joint infection (PJI), irrigation and debridement (I&D) with component retention is a treatment option with a wide variation in reported failure rates. The purpose of this study was to determine failure rates, outcomes, and factors that predict failure in I&D for TKA PJI. METHODS: A multicenter observational study of patients with a TKA PJI and subsequently undergoing an I&D with retention of components was conducted...
November 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29220338/basics-of-compounding-compounding-irrigation-solutions-for-sterile-and-nonsterile-preparations
#4
Loyd V Allen
Compounding pharmacists are sometimes called upon to prepare irrigation solutions, especially in the hospital or clinical setting. Irrigations are indicated for washing or bathing surgical incisions, wounds, and body tissues, including body cavities. Some irrigation solutions coming in contact with exposed tissue, must meet stringent requirements of sterility and bacterial endotoxins. Compounded irrigation solutions may involve wound(s), the bladder, and also may be for ophthalmic, otic, and nasal application...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219787/modification-of-the-biomedicus-centrifugal-pump-to-provide-continuous-irrigation-for-neuroendoscopy-technical-note
#5
Joyce Koueik, Brandon G Rocque, Jordan Henry, Taryn Bragg, Jennifer Paul, Bermans J Iskandar
Continuous irrigation is an important adjunct for successful intraventricular endoscopy, particularly for complex cases. It allows better visualization by washing out blood and debris, improves navigation by expanding the ventricles, and assists with tissue dissection. A method of irrigation delivery using a centrifugal pump designed originally for cardiac surgery is presented. The BioMedicus centrifugal pump has the desirable ability to deliver a continuous laminar flow of fluid that excludes air from the system...
December 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29217521/laser-balloon-or-wide-area-circumferential-irrigated-radiofrequency-ablation-for-persistent-atrial-fibrillation-a-multicenter-prospective-randomized-study
#6
Boris Schmidt, Petr Neuzil, Armin Luik, Joaquin Osca Asensi, Jan Wilko Schrickel, Thomas Deneke, Stefano Bordignon, Jan Petru, Matthias Merkel, Lucie Sediva, Annemarie Klostermann, Laura Perrotta, Oscar Cano, K R Julian Chun
BACKGROUND: Pulmonary vein isolation is the cornerstone of ablation for persistent atrial fibrillation (AF). The role of balloon catheters in this patient population remains ill defined. We sought to compare efficacy and safety of the laser balloon (LB) with wide-area circumferential pulmonary vein isolation using irrigated radiofrequency current (RF) ablation and 3-dimensional mapping. METHODS AND RESULTS: In 6 European centers, patients with persistent AF were prospectively randomized...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29217304/warming-of-irrigation-fluids-for-prevention-of-perioperative-hypothermia-during-arthroscopy-a-systematic-review-and-meta-analysis
#7
REVIEW
Victoria M Steelman, Sena Chae, Jed Duff, Michael J Anderson, Adnan Zaidi
PURPOSE: To determine whether warming of irrigation fluids (32°C-40°C) compared with using room-temperature irrigation fluids (20°C-22°C) decreases the risk of perioperative hypothermia (<36°C) for patients undergoing shoulder, hip, or knee arthroscopy. METHODS: One reviewer, with the assistance of a medical librarian, searched the following databases: PubMed, Embase, Cochrane Central, SPORTDiscus, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature)...
December 4, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29206787/outpatient-total-knee-arthroplasty-is-associated-with-higher-risk-of-perioperative-complications
#8
Armin Arshi, Natalie L Leong, Anthony D'Oro, Christopher Wang, Zorica Buser, Jeffrey C Wang, Kristofer J Jones, Frank A Petrigliano, Nelson F SooHoo
BACKGROUND: As concerns regarding health-care expenditure in the U.S. remain at the national forefront, outpatient arthroplasty is an appealing option for carefully selected patient populations. The purpose of this study was to determine the nationwide trends and complication rates associated with outpatient total knee arthroplasty (TKA) in comparison with standard inpatient TKA. METHODS: We performed a retrospective review of the Humana subset of the PearlDiver Patient Record Database to identify patients who had undergone TKA (Current Procedural Terminology [CPT] code 27447) as either outpatients or inpatients from 2007 to 2015...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29205169/potential-for-thermal-damage-to-the-blood-brain-barrier-during-craniotomy-procedure-implications-for-intracortical-recording-microelectrodes
#9
Andrew Shoffstall, Jennifer Paiz, David Miller, Griffin Rial, Mitchell Willis, Dhariyat Menendez, Stephen Hostler, Jeffrey R Capadona
Our objective was to determine how readily blood-brain barrier (BBB) disruption occurred as a result of bone drilling during a craniotomy to implant microelectrodes in rat cortex. While the phenomenon of heat production during bone-drilling is well-known, practices to evade damage to the underlying brain tissue are inconsistently practiced and reported in the literature. Approach: We conducted a review of intracortical microelectrode literature to summarize typical approaches to mitigate drill heating during rodent craniotomies...
December 5, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29204500/intraoperative-chlorhexidine-irrigation-to-prevent-infection-in-total-hip-and-knee-arthroplasty
#10
Nicholas B Frisch, Omar M Kadri, Troy Tenbrunsel, Abraham Abdul-Hak, Mossub Qatu, Jason J Davis
Background: Surgical site irrigation during total hip (THA) and total knee (TKA) arthroplasty is a routine practice among orthopaedic surgeons to prevent periprosthetic joint infection. The purpose of this study was to evaluate the effect of chlorhexidine gluconate (CHG) irrigation on infection rates following THA and TKA. Methods: Arthroplasties performed before September 2014 served as controls. THA performed before September 2014 (N = 253) underwent intraoperative irrigation with 0...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29203184/a-novel-modification-of-transurethral-enucleation-and-resection-of-the-prostate-in-patients-with-prostate-glands-larger-than-80-ml-surgical-procedures-and-clinical-outcomes
#11
Ke Li, Dejuan Wang, Cheng Hu, Yunhua Mao, Maoyin Li, Jie Si-Tu, Wentao Huang, Wenhan Qiu, Jianguang Qiu
OBJECTIVES: To evaluate efficacy and safety of the modified transurethral enucleation and resection of the prostate (M-TUERP) versus conventional bipolar transurethral resection of the prostate (B-TURP) for the treatment of prostates larger than 80 ml. METHODS: From April 2012 and May 2014, 86 patients with prostate volume > 80 ml were divided into two groups to undergo M-TUERP and B-TURP. In the M-TUERP group, we proposed combining the 12-mm trocar suprapubic cystostomy, and using the techniques of "umbrella-shaped resection", "point-resection" and "segmental-enucleation" to modify TUERP procedure...
December 1, 2017: Urology
https://www.readbyqxmd.com/read/29197193/negative-pressure-therapy-alone-or-with-irrigation-in-the-management-of-severe-peritonitis
#12
Mauro Andreano, Vito D'Ambrosio, Guido Coretti, Paolo Bianco, Simona Ruggiero, Umberto Robustelli, Maurizio Castriconi
BACKGROUND: Ogilvie was the first to publish on open abdomen (OA) for the treatment of the damages caused by penetrating abdominal wounds in war events. Research improved those devices that allow a controlled, homogeneous and continuous extraction of contaminated fluids from all abdominal recesses, which are nowadays the base of the "Open Abdomen" technique. MATERIALS AND METHODS: From August 2012 to February 2016 at the Department of Emergency Surgery of Cardarelli Hospital in Naples, 40 patients affected by Severe Peritonitis have been treated with OA technique...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29189540/the-short-term-effect-of-subtenon-sponge-application-versus-subtenon-irrigation-of-mitomycin-c-on-the-outcomes-of-trabeculectomy-with-ex-press-glaucoma-filtration-device-a-randomized-trial
#13
Michael S Quist, Ninita Brown, Amanda K Bicket, Leon W Herndon
PURPOSE: Traditionally, during trabeculectomy, Mitomycin-C (MMC) is applied to the tissues using surgical sponges. However, alternate modes of application exist. This study assessed the success rates, complication rates, final intraocular pressure (IOP) and bleb characteristics between patients receiving subtenon MMC application by sponge versus irrigation. PATIENTS & METHODS: 100 patients with glaucoma were enrolled and each was randomized to one of the two treatment groups...
November 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29176480/how-does-sinus-surgery-affect-topical-irrigation-distribution
#14
Sandro H de Paiva Leite, Richard G Douglas
PURPOSE OF REVIEW: The current article reviews the literature on the distribution of nasal irrigation in the treatment of chronic sinusitis, especially in how sinus surgery and irrigation techniques affect its delivery to the nasal cavity and paranasal sinuses. RECENT FINDINGS: Nasal irrigation has become a useful tool in the treatment of chronic sinusitis. Used after endoscopic surgery of the paranasal sinuses, irrigation has shown to be effective in improving edema and removing crusts and secretions in that place...
November 14, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29167718/preparation-prerequisites-for-effective-irrigation-of-apical-root-canal-a-critical-review
#15
REVIEW
Dimitrios Tziafas, Dana Alraeesi, Reem Al Hormoodi, Maamoun Ataya, Hessa Fezai, Nausheen Aga
Background: It is well recognized that disinfection of the complex root canal system at the apical root canal remains the most critical therapeutic measure to treat apical periodontitis. Material and Methods: Observational and experimental data in relation to the anatomy of the apical root canal in different tooth types and the cross sectional diameters of the apical part of the most commonly used hand and rotary files are critically reviewed. Results: The present data analysis confirm that the challenging issue of antibacterial efficacy of modern preparation protocols in non-surgical endodontics requires more attention to apical root canal irrigation as a balance between safety and effectiveness...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#16
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29145289/mercury-poisoning-through-intravenous-administration-two-case-reports-with-literature-review
#17
Qiuying Lu, Zilong Liu, Xiaorui Chen
RATIONALE: Metallic mercury poisoning through intravenous injection is rare, especially for a homicide attempt. Diagnosis and treatment of the disease are challenging. PATIENT CONCERNS: A 34-year-old male presented with pyrexia, chill, fatigue, body aches, and pain of the dorsal aspect of right foot. Another case is that of a 29-year-old male who committed suicide by injecting himself metallic mercury 15 g intravenously and presented with dizzy, dyspnea, fatigue, sweatiness, and waist soreness...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29141384/-problems-deserving-attention-in-preventing-infection-in-cataract-surgery
#18
J Ye
Endophthalmitis is one of the most serious complications of cataract surgery. The surgeons try to reduce the incidence of endophthalmitis. In order to prevent postoperative infection, irrigation of the conjunctival sac with povidone iodine and injection of antibiotics into the anterior chamber before the end of the surgery are used. Although there are a lot of reports about the concentration, mode and duration of povidone iodine application, there is no consensus. There are many options for antibiotics, including cefuroxime, vancomycin and moxifloxacin...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122621/simple-operating-room-bundle-reduces-superficial-surgical-site-infections-after-major-urologic-surgery
#19
Sarah C Vij, Ganesh Kartha, Venkatesh Krishnamurthi, Michelle Ponziano, Howard B Goldman
OBJECTIVE: To reduce our superficial surgical site infection rate (sSSI) following major urologic surgery by implementing a simple operating room bundle. METHODS: A simple operating room bundle was applied to all major urologic cases (cystectomy, nephrectomy and prostatectomy) at a single tertiary referral center. The bundle included allowing skin prep to dry appropriately, changing gloves prior to skin closure, irrigating the wound prior to skin closure and using a new separate sterile closing instrument set for skin closure...
November 6, 2017: Urology
https://www.readbyqxmd.com/read/29113855/holospinal-epidural-abscesses-institutional-experience
#20
REVIEW
Kelly J Bridges, Khoi D Than
PURPOSE: The authors present a holospinal epidural abscesses (HEA) case series and a single institution's experience with varied surgical approaches and outcomes. METHODS: Medical records were queried and reviewed (6 years) for patients with a spinal abscess diagnosis; HEA were selected. Medical history, comorbidities, blood and epidural pathogens, presentation symptoms, abscess location, presence of mass effect, surgical procedures, treatment regimens, and neurological outcomes were collected...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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