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JOURNAL ARTICLE
Bao-Fu Yu, Xiao-Xue Chen, Jia Liu, Jin-Guang He, Chuang-Chang Dai, Jiao Wei
SUMMARY: Nasal reconstruction in pediatric patient is very challenging and it requires consideration of later nasal development. Herein, we introduce an innovative preauricular free flap pedicled with retrograde vascular (PFFPRV) for pediatric nasal reconstruction. In this PFFPRV technique, the retrograde superficial temporal vessels were used as the flap pedicle. The lateral alar artery and angular vein were used as vessels of the nasal recipient zone. The flap vessels were anastomosed directly to the recipient area vessels without additional vessel transplantation...
April 18, 2024: Plastic and Reconstructive Surgery
#2
JOURNAL ARTICLE
Omer Faruk Egerci, Aliekber Yapar, Fırat Dogruoz, Huseyin Selcuk, Ozkan Kose
The increasing frequency of total hip (THA) and knee arthroplasties (TKA) is marred by the rise in periprosthetic joint infections (PJIs) and surgical site infections (SSIs), with PJIs incurring costs over $1.62 billion as of 2020 and individual case management averaging $90,000. SSIs additionally burden the U.S. healthcare economy with billions in expenses annually. PJI prevalence in primary THA and TKA ranges from 0.5% to 2.4%, spiking to 20% in revisions and representing 25% of TKA revision causes. Projections estimate up to 270,000 annual PJI cases by 2030...
April 18, 2024: Archives of Orthopaedic and Trauma Surgery
#3
REVIEW
Rohun Gupta, Joseph Weisberger, Isabel Herzog, Jacquelyn Roth, Edward S Lee
PURPOSE: High-energy injuries to the knee may lead to extensive soft tissue loss, fractures, and potential loss of extensor function. The gastrocnemius flap is a prominent reconstructive option for patients with injuries involving the knee and proximal third of the lower extremity. To the best of our knowledge, there has not been an informative review that has evaluated outcomes of patients who have undergone post-traumatic knee reconstruction with a pedicled medial or lateral gastrocnemius flap...
April 18, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#4
JOURNAL ARTICLE
Monique Motta, Nikitha Garapaty, Margaret Savage, Joann Segarra, Shenae Samuels, Joshua P Parreco, Tamar Levene
Currently, there is no universally accepted, standardized protocol for pre-operative antibiotic administration in the setting of appendectomy for complicated appendicitis among pediatric patients. Strategies to mitigate surgical site infections (SSIs) must be balanced with optimal antibiotic use and exposure. We conducted a retrospective chart review to compare outcomes between patients treated pre-operatively with a single pre-operative dose of antibiotics with those who received additional antibiotics prior to laparoscopic appendectomy for complicated appendicitis between 2020 and 2022...
April 18, 2024: American Surgeon
#5
JOURNAL ARTICLE
Emine Esra Bilir, Pinar Borman, Ayşe Merve Ata, Ebru Alemdaroğlu, Hatice Bodur, Burcu Yanık, Fatma Yurdakul, Bilge Kesikburun, Tuba Güler, Bedriye Başkan, Selami Akkuş, Oznur Uzun, Evren Yaşar
BACKGROUND: This descriptive analysis examines the victims of the February 6, 2023, earthquakes in Kahramanmaraş and Elbistan, Türkiye. It aims to detail the injury profiles related to neuro-musculoskeletal trauma, assess the rehabilitation needs of patients, and propose a comprehensive rehabilitation approach. METHODS: The study included patients injured in the Kahramanmaraş-centered earthquake on February 6, 2023, who were transported to our hospital based on their rehabilitation needs...
April 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
#6
JOURNAL ARTICLE
Jung Yun Park, Kwan Mo Yang, Jae Young Kwak, Yun Tae Jung
Background: Candida species account for approximately 15% of hospital-associated infections, causing fatal consequences, especially in critically ill patients. This study aimed to evaluate invasive candidiasis (IC) risk factors in critically ill patients undergoing surgery. Patients and Methods: We retrospectively reviewed the medical records of 583 patients who underwent emergency surgery for complicated intra-abdominal infections between January 2016 and December 2021. Patients were divided into two groups according to the presence or absence of IC during their hospital stay...
April 17, 2024: Surgical Infections
#7
JOURNAL ARTICLE
R N Komarov, D A Matsuganov, M D Nuzhdin, D O Bystrov, A O Danachev
OBJECTIVE: To compare the immediate results of mini-thoracotomy and sternotomy in patients with mitral valve disease. MATERIAL AND METHODS: The study included 52 patients who underwent mitral valve surgery (25 cases - mini-thoracotomy, 27 cases - sternotomy). RESULTS: Aortic cross-clamping time was significantly longer in sternotomy compared to mini-thoracotomy group - 110 vs 94 min ( p =0.03). Ventilation time was also significantly longer in the sternotomy group (12 vs...
2024: Khirurgiia
#8
JOURNAL ARTICLE
Ruihao Yang, Haoran Zhang, Yumo Chen, Linxuan Zhang, Jing Chu, Kang Sun, Congli Yuan, Ke Tao
Excessive blood loss and infections are the prominent risks accounting for mortality and disability associated with acute wounds. Consequently, wound dressings should encompass adequate adhesive, hemostatic, and bactericidal attributes, yet their development remains challenging. This investigation presented the benefits of incorporating a perfluorocarbon nanoemulsion (PPP NE) into a silk-fibroin (SF)-based hydrogel. By stimulating the β-sheet conformation of the SF chains, PPP NEs drastically shortened the gelation time while augmenting the elasticity, mechanical stability, and viscosity of the hydrogel...
April 18, 2024: ACS Applied Materials & Interfaces
#9
JOURNAL ARTICLE
Viral Patel, Ben Mueller, Amir A Mehbod, Manuel R Pinto, James D Schwender, Timothy A Garvey, John M Dawson, Joseph H Perra
INTRODUCTION: Controversy exists regarding whether spinal implants need to be removed to treat postoperative deep wound infections (DWIs). This retrospective study aimed to determine whether the removal or retention of implants impacts the successful treatment of a DWI after spine surgery. METHODS: Postoperative spine surgery patients presenting with signs of infection who underwent irrigation and debridement (I&D) at Twin Cities Spine Surgeons at Abbott Northwestern Hospital, Minnesota, USA, were studied...
March 2024: Curēus
#10
JOURNAL ARTICLE
Tessa E Muss, Sophia Hu, Andrew R Bauder, Ines C Lin
BACKGROUND: Gunshot wounds (GSWs) create significant morbidity in the United States. Upper extremity (UE) GSWs are at high risk of combined injuries involving multiple organ systems and may require variable treatment strategies. This study details the epidemiology, management, and outcomes of civilian UE GSWs at an urban level 1 trauma center. METHODS: Using the University of Pennsylvania Trauma Registry, all adult patients with UE GSWs from 2015 to 2020 who were at least 6-months postinjury were studied for demographics, injury pattern, operative details, and postoperative outcomes...
April 2024: Plastic and Reconstructive Surgery. Global Open
#11
Atul Parashar, Chandra Singh
BACKGROUND: Mucormycosis is a rare, rapidly progressive and often fatal fungal infection. The rarity of the condition lends itself to unfamiliarity, delayed treatment, and poor outcomes. Diagnosis of fungal infections early enough to enable appropriate treatment occurs in less than half of affected patients. CASE SUMMARY: An 11-year-old girl with a history of 15% total body surface area scald burns involving both lower limbs progressed to develop angioinvasive mucormycosis...
March 9, 2024: World Journal of Critical Care Medicine
#12
JOURNAL ARTICLE
Mohammed S Saddik, Mostafa F Al-Hakkani, Ahmed M Abu-Dief, Mohamed S Mohamed, Islam A Al-Fattah, Mahmoud Makki, Mohamed A El-Mokhtar, Marwa A Sabet, M S Amin, Hoda A Ahmed, Khalaf Al-Ghamdi, Mostafa K Mohammad, Mohammad H A Hassan
Infected wounds pose a significant challenge in healthcare, requiring innovative therapeutic strategies. Therefore, there is a critical need for innovative pharmaceutical materials to improve wound healing and combat bacterial growth. This study examined the efficacy of azithromycin-loaded silver nanoparticles (AZM-AgNPs) in treating infected wounds. AgNPs synthesized using a green method with Quinoa seed extract were loaded with AZM. Characterization techniques, including X-ray Powder Diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and Uv-Vis analysis were utilized...
June 2024: International journal of pharmaceutics: X
#13
Krishna Patel, Anthony N Rizzo, John Bach, William DeVoe
We report the case of a 71-year-old male who initially presented with urosepsis and was found to have a rib fracture of his right 6th rib with a flail segment and an associated abscess. Given the concern for infection, surgical rib fixation with titanium plating was not pursued during the washout of his abscess and instead, he successfully underwent rib fracture stabilization with bilateral suture transfixation. He was continued on a prolonged course of antibiotics for Klebsiella pneumonia osteomyelitis and was discharged uneventfully with optimal pain control and adequate respiratory effort...
June 2024: Trauma Case Reports
#14
JOURNAL ARTICLE
Zhao Guangxin, Chi Liqun, Liang Lin, Liu Jiaji, Ma Xiaolong, Zhang Yuxiao, Huang Qiuyue, Kong Qingyu
BACKGROUND: conventional coronary artery bypass grafting (CCABG) tends to cause severe complications in patients with comorbid Coronary Artery Diseases (CAD) and diabetes. On the other hand, the Minimally Invasive Cardiac Surgery Coronary Artery Bypass Grafting (MICS CABG) via transthoracic incision is associated with rapid recovery and reduced complications. Adding to the limited literature, this study compares CCABG and MICS CABG in terms of efficacy and safety. METHODS: Herein, 104 CCABG and MICS CABG cases (52 cases each) were included...
April 18, 2024: Journal of Cardiothoracic Surgery
#15
JOURNAL ARTICLE
Yaozheng Han, Jun Ma, Liangliang Huang, Lintao Su, Changyu Lei, Jianfeng Jiang, Hui Kang
OBJECTIVE: To investigate the effectiveness of injured vertebra fixation with inclined-long pedicle screws combined with interbody fusion for thoracolumbar fracture dislocation with disc injury. METHODS: Between January 2017 and June 2022, 28 patients with thoracolumbar fracture dislocation with disc injury were underwent posterior depression, the injured vertebra fixation with inclined-long pedicle screws, and interbody fusion. There were 22 males and 6 females, with a mean age of 41...
April 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
#16
JOURNAL ARTICLE
Yongqiang Kang, Yongwei Wu, Yongjun Rui, Qingqing Zhang, Yunhong Ma, Xueyuan Jia, Mingyu Zhang, Ming Zhou, Fang Lin
OBJECTIVE: To explore the effectiveness of using antibiotic bone cement-coated plates internal fixation technology as a primary treatment for Gustilo type ⅢB tibiofibular open fractures. METHODS: The clinical data of 24 patients with Gustilo type ⅢB tibiofibular open fractures who were admitted between January 2018 and December 2021 and met the selection criteria was retrospectively analyzed. Among them, there were 18 males and 6 females, aged from 25 to 65 years with an average age of 45...
April 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
#17
JOURNAL ARTICLE
Burcu Tülü, Şengül Üzen Cura
AIM: This research was conducted to determine the factors affecting the development of incontinence-associated dermatitis in intensive care patients. METHODS: The sample of the study consisted of 114 intensive care patients who developed incontinence-associated dermatitis. Patients were followed for a minimum of 8 days. The 'Patient Information Form' and the 'Incontinence-Associated Dermatitis and Severity Instrument (IADSI)' were used for data collection. The data were collected between February and May 2022...
April 11, 2024: Journal of Tissue Viability
#18
JOURNAL ARTICLE
Rabi Tawil, Kathryn R Wagner, Johanna I Hamel, Doris G Leung, Jeffrey M Statland, Leo H Wang, Angela Genge, Sabrina Sacconi, Hanns Lochmüller, David Reyes-Leiva, Jordi Diaz-Manera, Jorge Alonso-Perez, Nuria Muelas, Juan J Vilchez, Alan Pestronk, Summer Gibson, Namita A Goyal, Lawrence J Hayward, Nicholas Johnson, Samantha LoRusso, Miriam Freimer, Perry B Shieh, S H Subramony, Baziel van Engelen, Joost Kools, Olof Dahlqvist Leinhard, Per Widholm, Christopher Morabito, Christopher M Moxham, Diego Cadavid, Michelle L Mellion, Adefowope Odueyungbo, William G Tracewell, Anthony Accorsi, Lucienne Ronco, Robert J Gould, Jennifer Shoskes, Luis Alejandro Rojas, John G Jiang
BACKGROUND: Facioscapulohumeral muscular dystrophy is a hereditary progressive myopathy caused by aberrant expression of the transcription factor DUX4 in skeletal muscle. No approved disease-modifying treatments are available for this disorder. We aimed to assess the safety and efficacy of losmapimod (a small molecule that inhibits p38α MAPK, a regulator of DUX4 expression, and p38β MAPK) for the treatment of facioscapulohumeral muscular dystrophy. METHODS: We did a randomised, double-blind, placebo-controlled phase 2b trial at 17 neurology centres in Canada, France, Spain, and the USA...
May 2024: Lancet Neurology
#19
JOURNAL ARTICLE
Xiaojun Zhu, Jinxin Hu, Jiaming Lin, Guohui Song, Huaiyuan Xu, Jinchang Lu, Qinglian Tang, Jin Wang
AIMS: The aim of this study was to investigate the safety and efficacy of 3D-printed modular prostheses in patients who underwent joint-sparing limb salvage surgery (JSLSS) for malignant femoral diaphyseal bone tumours. METHODS: We retrospectively reviewed 17 patients (13 males and four females) with femoral diaphyseal tumours who underwent JSLSS in our hospital. RESULTS: In all, 17 patients with locally aggressive bone tumours (Enneking stage IIB) located in the femoral shaft underwent JSLSS and reconstruction with 3D-printed modular prostheses between January 2020 and June 2022...
April 18, 2024: Bone & joint open
#20
JOURNAL ARTICLE
Liyun Zhao, Liyuan Yao, Meilan Liu, Silin Qiu, Jiani He, Jindong Lin, Zhengguo Tao, Yu Lu, Shulin Deng, Hongfeng Chen, Sheng-Xiang Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Nocardiosis is an uncommon infectious disease that bears certain similarities to tuberculosis, with a continuous increase in its incidence and a poor prognosis. In traditional Chinese medicine, the leaves of Cajanus cajan (L.) Millsp. are employed to treat wounds, malaria, coughs, and abdominal pain. AIM OF THE STUDY: In this study, we investigated the effects and mechanisms of longistylin A (LGA), a natural stilbene isolated from C...
April 15, 2024: Journal of Ethnopharmacology
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