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https://www.readbyqxmd.com/read/29470651/prediction-of-surgical-site-infection-in-spine-surgery-from-tests-of-nasal-mrsa-colonization-and-drain-tip-culture
#1
Kazuyoshi Kobayashi, Kei Ando, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Shiro Imagama
PURPOSE: MRSA is an organism that is a possible risk factor for postoperative SSI. The purpose of the study was to examine relationships among surgical site infection (SSI) after spinal surgery, nasal methicillin-resistant staphylococcus aureus (MRSA) colonization, and wound drain culture results. METHODS: The subjects were 132 patients who underwent spinal instrumentation surgery. A preoperative nasal swab was used to check for the presence of MRSA colonization, and a wound drain tip culture was performed for detection of SSI...
February 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29470405/gentamicin-releasing-mesoporous-zno-structures
#2
Marco Laurenti, Valentina Cauda
Among metal oxides, zinc oxide (ZnO) is one of the most attractive materials thanks to its biocompatible and biodegradable properties along with the existence of various morphologies featuring piezoelectric, semiconducting and photocatalytic activities. All of these structures were successfully prepared and tested for numerous applications, including optoelectronics, sensors and biomedical ones. In the last case, biocompatible ZnO nanomaterials positively influenced cells growth and tissue regeneration as well, promoting wound healing and new bone formation...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29469751/staphylococcus-lugdunensis-cutaneous-infection-with-sporotrichoid-distribution
#3
Nicola Di Meo, Sara Trevisini, Cecilia Noal, Katiuscia Nan, Giusto Trevisan
We report the occurrence of Staphylococcus lugdunensis cutaneous infection with sporotrichoid distribution of the left lower limb of a 60-year-old man. Recent studies have confirmed that Staphylococcus lugdunensis is a significant pathogen in causing skin and soft tissue infections that usually manifest in abscesses, surgical wound infections, and cellulitis. It used to be considered a skin commensal bacteria, but if unrecognized it can lead to  fulminant endocarditis, meningitis, skin abscesses, peritonitis, and spondylodiscitis...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468490/negative-pressure-wound-therapy-reduces-the-motility-of-pseudomonas-aeruginosa-and-enhances-wound-healing-in-a-rabbit-ear-biofilm-infection-model
#4
Wang Guoqi, Li Zhirui, Wang Song, Li Tongtong, Zhang Lihai, Zhang Licheng, Tang Peifu
Pseudomonas aeruginosa motility, virulence factors and biofilms are known to be detrimental to wound healing. The efficacy of negative pressure wound therapy (NPWT) against P. aeruginosa has been little studied, either in vitro or in vivo. The present study evaluated the effect of negative pressure (NP) on P. aeruginosa motility in vitro, and the effect of NPWT on virulence factors and biofilms in vivo. P. aeruginosa motility was quantified under different levels of NP (atmospheric pressure, - 75, - 125, - 200 mmHg) using an in vitro model...
February 21, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29468142/-helicobacter-pylori-type-iv-secretion-system-and-its-adhesin-subunit-cagl-mediate-potent-inflammatory-responses-in-primary-human-endothelial-cells
#5
Mona Tafreshi, Jyeswei Guan, Rebecca J Gorrell, Nicole Chew, Yue Xin, Virginie Deswaerte, Manfred Rohde, Roger J Daly, Richard M Peek, Brendan J Jenkins, Elizabeth M Davies, Terry Kwok
The Gram-negative bacterium, Helicobacter pylori , causes chronic gastritis, peptic ulcers, and gastric cancer in humans. Although the gastric epithelium is the primary site of H. pylori colonization, H. pylori can gain access to deeper tissues. Concurring with this notion, H. pylori has been found in the vicinity of endothelial cells in gastric submucosa. Endothelial cells play crucial roles in innate immune response, wound healing and tumorigenesis. This study examines the molecular mechanisms by which H...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29467914/comprehensive-review-and-case-study-on-the-management-of-buried-penis-syndrome-and-related-panniculectomy
#6
Hadley Burns, J Stephen Gunn, Saeed Chowdhry, Thomas Lee, Steven Schulz, Bradon J Wilhelmi
Objective: This paper discusses the various surgical techniques and outcomes associated with management of buried penis syndrome. Methods: Presented is the case of a 49-year-old man with morbid obesity, leading to massive panniculus and buried penis. We review our technique for reconstruction of the buried penis and treatment of the overlying large panniculus. Literature search was conducted to review current techniques in correcting buried penis syndrome. Results: The patient underwent a successful panniculectomy with removal of all excess skin and tissue...
2018: Eplasty
https://www.readbyqxmd.com/read/29467483/clove-bud-oil-modulates-pathogenicity-phenotypes-of-the-opportunistic-human-pathogen-pseudomonas-aeruginosa
#7
Jayalekshmi Haripriyan, Athira Omanakuttan, Nitasha D Menon, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Ross Corriden, Bipin G Nair, Victor Nizet, Geetha B Kumar
Earlier studies from our laboratory have demonstrated that clove bud oil (CBO) attenuates expression of certain virulence factors of Pseudomonas aeruginosa PAO1. Here, we probe more deeply into the effect of CBO on four pseudomonal proteases - elastase A, elastase B, protease IV and alkaline protease - each known to play key roles in disease pathogenesis. CBO inhibited the activity of these proteases present in the bacterial culture supernatant. Zymography studies indicated that these proteases can activate host matrix metalloproteases (MMPs) to establish infection, through conversion of pro-MMP-2 to active MMP-2...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466894/a-preliminary-study-on-topical-ozonated-oil-in-the-therapeutic-management-of-atopic-dermatitis-in-murine
#8
J Lu, M Chen, L Gao, Q Cheng, Y Xiang, J Huang, K Wu, J Huang, M Li
Atopic dermatitis (AD) is an inflammatory skin disease characterized as a Th2-predominant immune response. Patients are susceptible to infection. Ozone is used for wound treatment due to its anti-infection features. However, it is unclear whether ozone can recovery AD lesions. In this study, mice were repeatedly challenged with the triplex allergens of staphylococcal enterotoxin B, ovalbumin and calcipotriol ointment on the back to develop AD lesions and were treated with ozonated oil. We found that ozonated oil significantly inhibited inflammation and healed the lesions in 7 days...
February 22, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29466457/far-uvc-light-prevents-mrsa-infection-of-superficial-wounds-in-vivo
#9
Brian Ponnaiya, Manuela Buonanno, David Welch, Igor Shuryak, Gerhard Randers-Pehrson, David J Brenner
BACKGROUND: Prevention of superficial surgical wound infections from drug-resistant bacteria such as methicillin resistant Staphylococcus aureus (MRSA) currently present major health care challenges. The majority of surgical site infections (SSI) are believed to be caused by airborne transmission of bacteria alighting onto the wound during surgical procedures. We have previously shown that far-ultraviolet C light in the wavelength range of 207-222 nm is significantly harmful to bacteria, but without damaging mammalian cells and tissues...
2018: PloS One
https://www.readbyqxmd.com/read/29465036/-mycobacterium-abscessus-infection-after-cosmetic-breast-surgery-in-india
#10
Ellen Jensen, Stine Holst-Albrechtsen, Kirsten Østergaard Christensen, Lene Birk-Sørensen, Jacob Juel
A 36-year-old Danish woman underwent cosmetic breast surgery in India. Post-operatively, she presented with infection and ulcers under the breasts, and dicloxacillin was administered. The patient did not return for follow-up. Two years later the ulcer under the right breast had not healed, and the patient returned to hospital, where a wound culture was done. The result showed Mycobacterium abscessus. Hence, cephalexin administration was instituted, but the ulcer did not heal, and it was excised. The subsequent healing was rapid...
February 12, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29464424/prevalence-and-risk-factors-for-ctx-m-gram-negative-bacteria-in-hospitalized-patients-at-a-tertiary-care-hospital-in-kilimanjaro-tanzania
#11
Tolbert Sonda, Happiness Kumburu, Marco van Zwetselaar, Michael Alifrangis, Blandina T Mmbaga, Ole Lund, Frank M Aarestrup, Gibson Kibiki
Emergence and spread of extended spectrum beta-lactamase (ESBL)-producing gram-negative bacteria, mainly due to CTX-M, is a major global public health problem. Patients infected with ESBL-producing gram-negative bacteria have an increased risk of treatment failure and death. We investigated the prevalence and risk factors for CTX-M gram-negative bacteria isolated from clinical specimens of patients hospitalized at a tertiary care hospital in Kilimanjaro, Tanzania. Isolated gram-negative bacteria from inpatients admitted at Kilimanjaro Christian Medical Centre (KCMC) between August 2013 and August 2015 were fully genome sequenced...
February 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29464230/the-australian-mid-west-coastal-marine-wound-infections-study
#12
Andy Foote, Robert Henderson, Andrew Lindberg, Carolyn Grigg, Charlie Greenfield, Andrew B Kirke, Kirsten Auret
BACKGROUND: Marine organism wound infections are common in coastal regions of Western Australia. Local treatment guidelines are based on studies from elsewhere. The objective of this article was to identify the causative organisms in marine wounds sustained in the subtropical and tropical coastal waters of the Indian Ocean, Gascoyne region (north-west), Western Australia. METHODS: This was a prospective study. A single wound swab was taken from 28 consenting patients who presented with a suppurating marine wound to the emergency departments of Carnarvon and Exmouth hospitals...
December 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29464174/suture-technique-to-prevent-air-leakage-during-negative-pressure-wound-therapy-in-fournier-gangrene
#13
Feng-Shu Chang, Chieh Chou, Chuan-Yu Hu, Shu-Hung Huang
Background: The use of negative-pressure wound therapy (NPWT) for Fournier gangrene management is well documented; however, it is difficult to fixate GranuFoam dressings and maintain an airtight seal over the perineum area. We developed a simple method to facilitate GranuFoam fixation and improve airtight sealing. Methods: The Fournier's gangrene severity index (FGSI) score less than 9 was collected in from January 2015 to October 2016. All 13 patients underwent fasciotomy, and NPWT was applied directly on fasciotomy wounds after the debridement of infected tissue...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29464150/incisional-negative-pressure-wound-therapy-for-prevention-of-wound-healing-complications-following-reduction-mammaplasty
#14
Robert D Galiano, Donald Hudson, Joseph Shin, René van der Hulst, Volkan Tanaydin, Risal Djohan, Franck Duteille, John Cockwill, Sarah Megginson, Elizabeth Huddleston
Background: It has been proposed that negative pressure wound therapy (NPWT) applied prophylactically to a closed incision may decrease the incidence of wound complications. Patients undergoing reduction mammaplasty are at risk of wound complications such as delayed healing, infection, and dehiscence, and the bilateral nature of the surgery allows for a within-patient randomized study to evaluate incisional NPWT's effect in reducing healing complications. Methods: In this multicenter trial, 200 patients undergoing bilateral reduction mammaplasty were treated with PICO Single-Use NPWT System or standard wound-care dressings randomized to right or left breast for up to 14 days to enable within-patient comparison...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463436/what-is-the-impact-of-smoking-on-revision-total-hip-arthroplasty
#15
Nicholas A Bedard, S Blake Dowdle, Jessell M Owens, Kyle R Duchman, Yubo Gao, John J Callaghan
BACKGROUND: There is a literature evaluating the impact of smoking on revision total hip arthroplasty (THA) outcomes. The purpose of this study was to identify the effect of smoking on complications after revision THA. METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Program database to identify patients who underwent revision THA between 2006 and 2014. Patients were divided into current smokers and nonsmokers. Each cohort was compared in terms of demographics, preoperative comorbidities, and operative time...
January 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29463320/medialisation-thyroplasty-with-tensor-fascia-lata-a-novel-approach-for-reducing-post-thyroplasty-complications
#16
T N Chao, A Mahmoud, K Rajasekaran, N Mirza
BACKGROUND: Medialisation thyroplasty is considered the 'gold standard' treatment for unilateral vocal fold paralysis, enabling improvement of voice and swallowing function, and preventing life-threatening aspiration events. The most commonly used laryngeal implants induce some degree of local tissue inflammatory response, and carry the risk of immediate or delayed implant extrusion. METHODS: This paper describes a novel approach for medialisation thyroplasty. Specifically, it utilises a ribbon of autologous tensor fascia lata harvested at the time of surgery...
February 21, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29463211/team-up-for-quality-a-cluster-randomized-controlled-trial-protocol-focused-on-preventing-pressure-ulcers-through-repositioning-frequency-and-precipitating-factors
#17
Tracey L Yap, Susan M Kennerly, Susan D Horn, Nancy Bergstrom, Santanu Datta, Cathleen Colon-Emeric
BACKGROUND: Pressure ulcers/injuries (PrUs), a critical concern for nursing homes (NH), are responsible for chronic wounds, amputations, septic infections, and premature deaths. PrUs occur most commonly in older adults and NH residence is a risk factor for their development, with at least one of every nine U.S. NH residents experiencing a PrU and many NHs having high incidence and prevalence rates, in some instances well over 20%. PrU direct treatment costs are greater than prevention costs, making prevention-focused protocols critical...
February 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29463199/airborne-particulate-matter-impairs-corneal-epithelial-cells-migration-via-disturbing-fak-rhoa-signaling-pathway-and-cytoskeleton-organization
#18
Yu-Hong Cui, Zi-Xuan Hu, Zi-Xun Gao, Xi-Ling Song, Qing-Yang Feng, Guang Yang, Zhi-Jie Li, Hong-Wei Pan
BACKGROUND: Cornea is the outmost structure of the eye and exposed directly to the air pollution. However, little is known about the effect of PM2.5 on corneal epithelium, which is critical for maintenance of cornea homeostasis and visual function. OBJECTIVE: We investigated the influence of PM2.5 exposure on corneal epithelial migration and the possible mechanisms involved in the process. METHODS: We observed wound healing in mouse model of cornea abrasion, evaluated the migration and mobility of cultured corneal epithelial cells with wound scratch assay and Transwell migration assay, detected the phosphorylation and interaction of FAK/paxillin with immunofluorescence and immunoprecipitation, and determined the RhoA activity and actin reorganization, in response to PM2...
February 20, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29462687/recent-advances-on-antimicrobial-wound-dressing-a-review
#19
REVIEW
Déborah Simões, Sónia P Miguel, Maximiano P Ribeiro, Paula Coutinho, António G Mendonça, Ilídio J Correia
Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrobial agents emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process...
February 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29460174/management-of-closed-sternal-incision-after-bilateral-internal-thoracic-artery-grafting-with-a-single-use-negative-pressure-system
#20
Giuseppe Gatti, Miroslaw Ledwon, Laszlo Gazdag, Federica Cuomo, Aniello Pappalardo, Theodor Fischlein, Giuseppe Santarpino
Single-use, closed incision management (CIM) systems offer a practical means of delivering negative pressure wound therapy to patients. This prospective study evaluates the Prevena™ Therapy system in a cohort of coronary patients at high risk of deep sternal wound infection (DSWI). Fifty-three consecutive patients undergoing bilateral internal thoracic artery (BITA) grafting were preoperatively elected for CIM with the Prevena™ Therapy system, which was applied immediately after surgery. The actual rate of DSWI in these patients was compared with the expected risk of DSWI according to two scoring systems specifically created to predict either DSWI after BITA grafting (Gatti score) or major infections after cardiac surgery (Fowler score)...
February 19, 2018: Updates in Surgery
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