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Jennifer Abbasi
No abstract text is available yet for this article.
October 25, 2016: JAMA: the Journal of the American Medical Association
Decio Brunoni, Silvana Maria Blascovi-Assis, Ana Alexandra Caldas Osório, Alessandra Gotuzo Seabra, Cibelle Albuquerque de la Higuera Amato, Maria Cristina Triguero Veloz Teixeira, Marina Monzani da Rocha, Luiz Renato Rodrigues Carreiro
The present study aimed to present an overview of recent national and international research on the Zika virus (ZIKV), as well as to explore possible action plans focused on children, their families and the health teams involved.Therefore, the study proposes the implementation of tracking systems in order to identify, describe and characterize the potential correlates of prenatal exposure to ZIKV, divided into three lines of action: 1. Diagnostic and etiological evaluation as well as screening of developmental problems in children confirmed or suspected of prenatal ZIKV infection...
October 2016: Ciência & Saúde Coletiva
Andrew D Haddow, Farooq Nasar, Hilda Guzman, Alongkot Ponlawat, Richard G Jarman, Robert B Tesh, Scott C Weaver
BACKGROUND: Zika virus (ZIKV) has extended its known geographic distribution to the New World and is now responsible for severe clinical complications in a subset of patients. While substantial genetic and vector susceptibility data exist for ZIKV, less is known for the closest related flavivirus, Spondweni virus (SPONV). Both ZIKV and SPONV have been known to circulate in Africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. Furthermore, the susceptibility of peridomestic mosquito species incriminated or suspected in the transmission of ZIKV to SPONV was unknown...
October 2016: PLoS Neglected Tropical Diseases
James Weger-Lucarelli, Claudia Rückert, Nunya Chotiwan, Chilinh Nguyen, Selene M Garcia Luna, Joseph R Fauver, Brian D Foy, Rushika Perera, William C Black, Rebekah C Kading, Gregory D Ebel
In 2015, Zika virus (ZIKV; Flaviviridae; Flavivirus) emerged in the Americas, causing millions of infections in dozens of countries. The rapid spread of the virus and the association with disease outcomes such as Guillain-Barré syndrome and microcephaly make understanding transmission dynamics essential. Currently, there are no reports of vector competence (VC) of American mosquitoes for ZIKV isolates from the Americas. Further, it is not clear whether ZIKV strains from other genetic lineages can be transmitted by American Aedes aegypti populations, and whether the scope of the current epidemic is in part facilitated by viral factors such as enhanced replicative fitness or increased vector competence...
October 2016: PLoS Neglected Tropical Diseases
Jaime A Cardona-Ospina, Juan C Sepúlveda-Arias, L Mancilla, Luis G Gutierrez-López
Plant expression systems could be used as biofactories of heterologous proteins that have the potential to be used with biopharmaceutical aims and vaccine design. This technology is scalable, safe and cost-effective and it has been previously proposed as an option for vaccine and protein pharmaceutical development in developing countries. Here we present a proposal of how plant expression systems could be used to address Zika and chikungunya outbreaks through development of vaccines and rapid diagnostic kits...
2016: F1000Research
Hong Liu, Liang Shen, Xiao-Lin Zhang, Xiao-Long Li, Guo-Dong Liang, Hong-Fang Ji
No abstract text is available yet for this article.
October 26, 2016: Emerging Microbes & Infections
Christian L Althaus, Nicola Low
Christian Althaus and Nicola Low reflect on the contribution of sexual transmission to the spread of Zika virus.
October 2016: PLoS Medicine
Radha V Patel, Kristy M Shaeer, Pooja Patel, Aleksey Garmaza, Kornwalee Wiangkham, Rachel B Franks, Olivia Pane, Nicholas W Carris
In many parts of the United States, mosquitoes were previously nuisance pests. However, they now represent a potential threat in the spread of viral diseases. The Aedes aegypti, Aedes albopictus, and Culex species mosquitoes are endemic to the United States and together may transmit a variety of viral diseases of growing concern including West Nile Virus, chikungunya, dengue fever, and Zika virus. The Centers for Disease Control and Prevention (CDC) and the Environmental Protection Agency (EPA) recommend N,N-diethyl-meta-toluamide (DEET) as a first-line mosquito repellent, but for patients refusing DEET or other conventional repellents, guidance is limited to any EPA-registered product...
October 25, 2016: Pharmacotherapy
Emilio Dirlikov, Krista Kniss, Chelsea Major, Dana Thomas, Cesar A Virgen, Marrielle Mayshack, Jason Asher, Luis Mier-Y-Teran-Romero, Jorge L Salinas, Daniel M Pastula, Tyler M Sharp, James Sejvar, Michael A Johansson, Brenda Rivera-Garcia
To assist with public health preparedness activities, we estimated the number of expected cases of Zika virus in Puerto Rico and associated healthcare needs. Estimated annual incidence is 3.2-5.1 times the baseline, and long-term care needs are predicted to be 3-5 times greater than in years with no Zika virus.
January 15, 2017: Emerging Infectious Diseases
Megha Sharma, Kapil Yadav, Nitika Yadav, Keith C Ferdinand
The arrival of Zika virus in the United States has generated a lot of activity on social media focusing on the algorithmic increase in the spread of the disease and its concerning complications. Accurate and credible dissemination of correct information about the arbovirus could help in decreasing the pandemic spread and associated apprehension in the population. Our study examined the effective use of the social media site Facebook (Facebook Inc, Menlo Park, CA) as an information source for the Zika virus pandemic...
October 21, 2016: American Journal of Infection Control
Richard Lindqvist, Filip Mundt, Jonathan D Gilthorpe, Silke Wölfel, Nelson O Gekara, Andrea Kröger, Anna K Överby
BACKGROUND: Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined...
October 24, 2016: Journal of Neuroinflammation
Jan M Kriebs
No abstract text is available yet for this article.
October 2016: Journal of Perinatal & Neonatal Nursing
Jin-Na Wang, Feng Ling
Zika virus (ZIKV) is a flavivirus related to the Dengue, yellow fever and West Nile viruses. Since the explosive outbreaks of ZIKV in Latin America in 2015, a sudden increase in the number of microcephaly cases has been observed in infants of women who were pregnant when they contracted the virus. The severity of this condition raises grave concerns, and extensive studies on the possible link between ZIKV infection and microcephaly have been conducted. There is substantial evidence suggesting that there is a causal link between ZIKV and microcephaly, however, future studies are warranted to solidify this association...
October 20, 2016: International Journal of Environmental Research and Public Health
A Bennouna, T Balenghien, H El Rhaffouli, F Schaffner, C Garros, L Gardès, Y Lhor, S Hammoumi, G Chlyeh, O Fassi Fihri
The Asian tiger mosquito Stegomyia albopicta (= Aedes albopictus) (Diptera: Culicidae), native to Asian forests, is a nuisance mosquito and is responsible for the transmission of arboviruses of public health importance, such as dengue, chikungunya and Zika viruses. It has colonized parts of all continents, except Antarctica, over the past 30-40 years. However, to date, the only records of S. albopicta in North Africa refer to occasional collections in 2010 and 2014 in Algeria. In early September 2015, S...
October 24, 2016: Medical and Veterinary Entomology
Biao Tang, Yanni Xiao, Jianhong Wu
Zika virus co-circulates with dengue in tropical and sub-tropical regions. Cases of co-infection by dengue and Zika have been reported, the implication of this co-infection for an integrated intervention program for controlling both dengue and Zika must be addressed urgently. Here, we formulate a mathematical model to describe the transmission dynamics of co-infection of dengue and Zika with particular focus on the effects of Zika outbreak by vaccination against dengue among human hosts. Our analysis determines specific conditions under which vaccination against dengue can significantly increase the Zika outbreak peak, and speed up the Zika outbreak peak timing...
October 24, 2016: Scientific Reports
Gianluigi Lichinchi, Boxuan Simen Zhao, Yinga Wu, Zhike Lu, Yue Qin, Chuan He, Tariq M Rana
Infection with the flavivirus Zika (ZIKV) causes neurological, immunological, and developmental defects through incompletely understood mechanisms. We report that ZIKV infection affects viral and human RNAs by altering the topology and function of N(6)-adenosine methylation (m(6)A), a modification affecting RNA structure and function. m(6)A nucleosides are abundant in ZIKV RNA, with twelve m(6)A peaks identified across full-length ZIKV RNA. m(6)A in ZIKV RNA is controlled by host methyltransferases METTL3 and METTL14 and demethylases ALKBH5 and FTO, and knockdown of methyltransferases increases, while silencing demethylases decreases, ZIKV production...
October 18, 2016: Cell Host & Microbe
Nandan S Gokhale, Alexa B R McIntyre, Michael J McFadden, Allison E Roder, Edward M Kennedy, Jorge A Gandara, Sharon E Hopcraft, Kendra M Quicke, Christine Vazquez, Jason Willer, Olga R Ilkayeva, Brittany A Law, Christopher L Holley, Mariano A Garcia-Blanco, Matthew J Evans, Mehul S Suthar, Shelton S Bradrick, Christopher E Mason, Stacy M Horner
The RNA modification N6-methyladenosine (m(6)A) post-transcriptionally regulates RNA function. The cellular machinery that controls m(6)A includes methyltransferases and demethylases that add or remove this modification, as well as m(6)A-binding YTHDF proteins that promote the translation or degradation of m(6)A-modified mRNA. We demonstrate that m(6)A modulates infection by hepatitis C virus (HCV). Depletion of m(6)A methyltransferases or an m(6)A demethylase, respectively, increases or decreases infectious HCV particle production...
October 18, 2016: Cell Host & Microbe
Sineewanlaya Wichit, Pauline Ferraris, Valérie Choumet, Dorothée Missé
Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components...
October 19, 2016: Current Opinion in Virology
Maggy T Sikulu-Lord, Masabho P Milali, Michael Henry, Robert A Wirtz, Leon E Hugo, Floyd E Dowell, Gregor J Devine
Estimating the age distribution of mosquito populations is crucial for assessing their capacity to transmit disease and for evaluating the efficacy of available vector control programs. This study reports on the capacity of the near-infrared spectroscopy (NIRS) technique to rapidly predict the ages of the principal dengue and Zika vector, Aedes aegypti. The age of wild-type males and females, and males and females infected with wMel and wMelPop strains of Wolbachia pipientis were characterized using this method...
October 2016: PLoS Neglected Tropical Diseases
Antonio Augusto Moura da Silva, Jucelia Sousa Santos Ganz, Patricia da Silva Sousa, Maria Juliana Rodvalho Doriqui, Marizelia Rodrigues Costa Ribeiro, Maria Dos Remédios Freitas Carvalho Branco, Rejane Christine de Sousa Queiroz, Maria de Jesus Torres Pacheco, Flavia Regina Vieira da Costa, Francelena de Sousa Silva, Vanda Maria Ferreira Simões, Marcos Antonio Barbosa Pacheco, Fernando Lamy-Filho, Zeni Carvalho Lamy, Maria Teresa Seabra Soares de Britto E Alves
We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1-8 months. Most of these infants had microcephaly (86.7%) and craniofacial disproportion (95.8%). The clinical pattern included poor head growth with increasingly negative z-scores, pyramidal/extrapyramidal symptoms, and epilepsy.
November 2016: Emerging Infectious Diseases
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