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https://www.readbyqxmd.com/read/28938115/a-human-bi-specific-antibody-against-zika-virus-with-high-therapeutic-potential
#1
Jiaqi Wang, Marco Bardelli, Diego A Espinosa, Mattia Pedotti, Thiam-Seng Ng, Siro Bianchi, Luca Simonelli, Elisa X Y Lim, Mathilde Foglierini, Fabrizia Zatta, Stefano Jaconi, Martina Beltramello, Elisabetta Cameroni, Guntur Fibriansah, Jian Shi, Taylor Barca, Isabel Pagani, Alicia Rubio, Vania Broccoli, Elisa Vicenzi, Victoria Graham, Steven Pullan, Stuart Dowall, Roger Hewson, Simon Jurt, Oliver Zerbe, Karin Stettler, Antonio Lanzavecchia, Federica Sallusto, Andrea Cavalli, Eva Harris, Shee-Mei Lok, Luca Varani, Davide Corti
Zika virus (ZIKV), a mosquito-borne flavivirus, causes devastating congenital birth defects. We isolated a human monoclonal antibody (mAb), ZKA190, that potently cross-neutralizes multi-lineage ZIKV strains. ZKA190 is highly effective in vivo in preventing morbidity and mortality of ZIKV-infected mice. NMR and cryo-electron microscopy show its binding to an exposed epitope on DIII of the E protein. ZKA190 Fab binds all 180 E protein copies, altering the virus quaternary arrangement and surface curvature...
September 21, 2017: Cell
https://www.readbyqxmd.com/read/28937149/neuro-oncology-a-new-role-for-zika-virus-in-glioblastoma-therapy
#2
Heather Wood
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28934970/isolation-and-identification-of-xenorhabdus-and-photorhabdus-bacteria-associated-with-entomopathogenic-nematodes-and-their-larvicidal-activity-against-aedes-aegypti
#3
Chamaiporn Fukruksa, Thatcha Yimthin, Manawat Suwannaroj, Paramaporn Muangpat, Sarunporn Tandhavanant, Aunchalee Thanwisai, Apichat Vitta
BACKGROUND: Aedes aegypti is a potential vector of West Nile, Japanese encephalitis, chikungunya, dengue and Zika viruses. Alternative control measurements of the vector are needed to overcome the problems of environmental contamination and chemical resistance. Xenorhabdus and Photorhabdus are symbionts in the intestine of entomopathogenic nematodes (EPNs) Steinernema spp. and Heterorhabditis spp. These bacteria are able to produce a broad range of bioactive compounds including antimicrobial, antiparasitic, cytotoxic and insecticidal compounds...
September 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28934431/genetic-profiling-and-comorbidities-of-zika-infection
#4
Mohammad Ali Moni, Pietro Lio'
Background: The difficulty in distinguishing infection by Zika virus (ZIKV) from other flaviviruses is a global health concern, particularly given the high risk of neurologic complications (including Guillain-Barré syndrome [GBS]) with ZIKV infection. Methods: We developed quantitative frameworks to compare and explore infectome, diseasome, and comorbidity of ZIKV infections. We analyzed gene expression microarray and RNA-Seq data from ZIKV, West Nile fever (WNF), chikungunya, dengue, yellow fever, Japanese encephalitis virus, GBS, and control datasets...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934370/the-risk-of-sustained-sexual-transmission-of-zika-is-underestimated
#5
Antoine Allard, Benjamin M Althouse, Laurent Hébert-Dufresne, Samuel V Scarpino
Pathogens often follow more than one transmission route during outbreaks-from needle sharing plus sexual transmission of HIV to small droplet aerosol plus fomite transmission of influenza. Thus, controlling an infectious disease outbreak often requires characterizing the risk associated with multiple mechanisms of transmission. For example, during the Ebola virus outbreak in West Africa, weighing the relative importance of funeral versus health care worker transmission was essential to stopping disease spread...
September 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28934352/global-reaction-to-the-recent-outbreaks-of-zika-virus-insights-from-a-big-data-analysis
#6
Nicola Luigi Bragazzi, Cristiano Alicino, Cecilia Trucchi, Chiara Paganino, Ilaria Barberis, Mariano Martini, Laura Sticchi, Eugen Trinka, Francesco Brigo, Filippo Ansaldi, Giancarlo Icardi, Andrea Orsi
OBJECTIVE: The recent spreading of Zika virus represents an emerging global health threat. As such, it is attracting public interest worldwide, generating a great amount of related Internet searches and social media interactions. The aim of this research was to understand Zika-related digital behavior throughout the epidemic spreading and to assess its consistence with real-world epidemiological data, using a behavioral informatics and analytics approach. METHODS: In this study, the global web-interest and reaction to the recently occurred outbreaks of the Zika Virus were analyzed in terms of tweets and Google Trends (GT), Google News, YouTube, and Wikipedia search queries...
2017: PloS One
https://www.readbyqxmd.com/read/28934211/differential-virulence-between-asian-and-african-lineages-of-zika-virus
#7
Yannick Simonin, Debby van Riel, Philippe Van de Perre, Barry Rockx, Sara Salinas
No abstract text is available yet for this article.
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28933344/first-outbreak-of-zika-virus-in-the-continental-united-states-a-modelling-analysis
#8
Giovanni Marini, Giorgio Guzzetta, Roberto Rosà, Stefano Merler
Since 2015, Zika virus (ZIKV) has spread throughout Latin and Central America. This emerging infectious disease has been causing considerable public health concern because of severe neurological complications, especially in newborns after congenital infections. In July 2016, the first outbreak in the continental United States was identified in the Wynwood neighbourhood of Miami-Dade County, Florida. In this work, we investigated transmission dynamics using a mathematical model calibrated to observed data on mosquito abundance and symptomatic human infections...
September 14, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28932814/the-gut-commensal-microbiome-of-drosophila-melanogaster-is-modified-by-the-endosymbiont-wolbachia
#9
Rama K Simhadri, Eva M Fast, Rong Guo, Michaela J Schultz, Natalie Vaisman, Luis Ortiz, Joanna Bybee, Barton E Slatko, Horacio M Frydman
Endosymbiotic Wolbachia bacteria and the gut microbiome have independently been shown to affect several aspects of insect biology, including reproduction, development, life span, stem cell activity, and resistance to human pathogens, in insect vectors. This work shows that Wolbachia bacteria, which reside mainly in the fly germline, affect the microbial species present in the fly gut in a lab-reared strain. Drosophila melanogaster hosts two main genera of commensal bacteria-Acetobacter and Lactobacillus. Wolbachia-infected flies have significantly reduced titers of Acetobacter...
September 2017: MSphere
https://www.readbyqxmd.com/read/28932709/trehalose-may-decrease-the-transmission-of-zika-virus-to-the-fetus-by-activating-degradative-autophagy
#10
Shu Yuan, Zhong-Wei Zhang, Zi-Lin Li
No abstract text is available yet for this article.
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28932235/zika-virus-congenital-syndrome-experimental-models-and-clinical-aspects
#11
REVIEW
Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui, Jean Pierre Schatzmann Peron
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28931684/zika-virus-encoding-non-glycosylated-envelope-protein-is-attenuated-and-defective-in-neuroinvasion
#12
Arun S Annamalai, Aryamav Pattnaik, Bikash R Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep L X Vu, Gustavo Delhon, Fernando A Osorio, Thomas M Petro, Shi-Hua Xiang, Asit K Pattnaik
Zika virus (ZIKV), a mosquito-transmitted flavivirus, responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, re-emerged in the last decade causing serious human diseases including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently outstanding. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic, being absent in many of the African isolates while present in all isolates from the recent outbreaks...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28931227/enhancement-of-zika-infection-by-dengue-specific-antibodies-does-not-alter-the-production-of-interleukin-6-in-fc%C3%AE-rii-expressing-k562-cells
#13
Priscila M S Castanha, Eduardo J M Nascimento, Cynthia Braga, Marli T Cordeiro, Otávio V de Carvalho, Leila R de Mendonça, Elisa A N Azevedo, Rafael F O França, Rafael Dhalia, Ernesto T A Marques
No abstract text is available yet for this article.
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931226/enhancement-of-zika-infection-by-dengue-virus-specific-antibody-is-associated-with-low-levels-of-antiviral-factors
#14
Linda Hueston, Ruben Ramirez, Suresh Mahalingam
No abstract text is available yet for this article.
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28930015/zika-virus-persistence-and-higher-viral-loads-in-cutaneous-capillaries-than-in-venous-blood
#15
Séverine Matheus, Franck de Laval, David Moua, Christophe N'Guyen, Enguerrane Martinez, Dominique Rousset, Sébastien Briolant
We collected venous and capillary serum samples from 21 Zika virus‒infected patients on multiple days after symptom onset and found RNA load was higher and median duration of virus detection significantly longer in capillary than in venous blood. These findings raise questions about the role of the capillary compartment in virus transmission dynamics.
November 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28929534/emerging-arboviruses-in-rio-grande-do-sul-brazil-chikungunya-and-zika-outbreaks-2014-2016
#16
Tatiana Schäffer Gregianini, Tani Ranieri, Cátia Favreto, Zenaida Marion Alves Nunes, Gabriela Luchiari Tumioto Giannini, Nara Druck Sanberg, Marilda Tereza Mar da Rosa, Ana Beatriz Gorini da Veiga
QUESTIONS INVESTIGATED: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures. DESIGN: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016...
September 20, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28928720/potential-risk-areas-of-aedes-albopictus-in-south-eastern-iran-a-vector-of-dengue-fever-zika-and-chikungunya
#17
Jalil Nejati, Rubén Bueno-Marí, Francisco Collantes, Ahmad A Hanafi-Bojd, Hassan Vatandoost, Zabihollah Charrahy, Seyed M Tabatabaei, Mohammad R Yaghoobi-Ershadi, Abdolghafar Hasanzehi, Mohammad R Shirzadi, Seyed H Moosa-Kazemi, Mohammad M Sedaghat
The possibility of the rapid and global spread of Zika, chikungunya, yellow fever, and dengue fever by Aedes albopictus is well documented and may be facilitated by changes in climate. To avert and manage health risks, climatic and topographic information can be used to model and forecast which areas may be most prone to the establishment of Ae. albopictus. We aimed to weigh and prioritize the predictive value of various meteorological and climatic variables on distributions of Ae. albopictus in south-eastern Iran using the Analytical Hierarchy Process...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928416/zika-virus-infection-confers-protection-against-west-nile-virus-challenge-in-mice
#18
Ángela Vázquez-Calvo, Ana-Belén Blázquez, Estela Escribano-Romero, Teresa Merino-Ramos, Juan-Carlos Saiz, Miguel A Martín-Acebes, Nereida Jiménez de Oya
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. Zika virus (ZIKV), which was initially reported to cause a mild disease, recently spread in the Americas, infecting millions of people. During this recent epidemic, ZIKV infection has been linked to serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome (GBS) and microcephaly. Because information about ZIKV immunity remains scarce, we assessed the humoral response of immunocompetent mice to infection with three viral strains of diverse geographical origin (Africa, Asia and America)...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28928377/viral-outbreaks-involve-destabilized-evolutionary-networks-evidence-from-ebola-influenza-and-zika
#19
Stéphane Aris-Brosou, Neke Ibeh, Jessica Noël
Recent history has provided us with one pandemic (Influenza A/H1N1) and two severe viral outbreaks (Ebola and Zika). In all three cases, post-hoc analyses have given us deep insights into what triggered these outbreaks, their timing, evolutionary dynamics, and phylogeography, but the genomic characteristics of outbreak viruses are still unclear. To address this outstanding question, we searched for a common denominator between these recent outbreaks, positing that the genome of outbreak viruses is in an unstable evolutionary state, while that of non-outbreak viruses is stabilized by a network of correlated substitutions...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927874/zika-detection-comparison-of-methodologies
#20
Tatiana Elias Colombo, Ana Carolina Bernardes Terzian, João Pessoa Araújo Júnior, Ricardo Parreira, Eliana Márcia Sotello Cabrera, Izalco Nuremberg Penha Dos Santos, Andréia Francesli Negri Reis, Fabiana Rodrigues Costa, Lilian Elisa Arão Antônio Cruz, Patrícia Lopes Rombola, Maurício Lacerda Nogueira
Many countries in the Americas have detected local transmission of multiple arboviruses that cause febrile illnesses. Therefore, laboratory testing has become an important tool for confirming the etiology of these diseases. The present study aimed to compare the sensitivity and specificity of three different Zika virus detection assays. One hundred serum samples from patients presenting with acute febrile symptoms were tested using a previously reported TaqMan(®) RT-qPCR assay. We used a SYBR(®) Green RT-qPCR and a conventional PCR methodologies to compare the results...
August 30, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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