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Gordian knot

Xiaoyu Xia, Yi Yang, Yongkun Guo, Yang Bai, Yuanyuan Dang, Ruxiang Xu, Jianghong He
Treatment for disorders of consciousness (DOCs) is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and non-invasive brain stimulation is discussed...
June 18, 2018: Neuroscience Bulletin
Barbara F Brandt, Simon Kitto, Ronald M Cervero
The National Collaborative for Improving the Clinical Learning Environment (NCICLE) is a growing group of over 40 organizations representing a variety of health professions. NCICLE is beginning a discussion of issues related to culture in health care, specifically how the current culture inhibits optimal outcomes, and the discordance between current early interprofessional education (IPE) curricula in health professions schools and traditional practice models in health care. In October 2017, the Accreditation Council for Graduate Medical Education and the Josiah Macy Jr...
June 12, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Kimberly S Vasquez, Anthony L Shiver, Kerwyn Casey Huang
The gut microbiota plays a central role in human health. Studies by Tramontano et al. (2018) and Maier et al. (2018) improve our understanding of the metabolism and pharmaceutical impact of human gut bacteria through high-throughput screening of growth in the presence of different nutrients and drugs, respectively.
June 7, 2018: Molecular Cell
Susan E Barbour
Candidates frequently accept one or multiple low-fee cases as part of their training experience. Although the practical and unconscious meanings of the formerly taboo topic of money have recently been discussed in the literature, the candidate's experience in regard to the fee is rarely discussed. The author argues that the candidate is positioned to face a Gordian knot of personal, training, and clinical intensity in the duration of training that impacts casework. This paper discusses two prototypical characterological constellations related to the fee...
June 2018: Psychoanalytic Review
Konstantinos Toutouzas, Georgios Benetos, Dimitris Tousoulis
No abstract text is available yet for this article.
January 1, 2018: Angiology
Bhawana Bissa, Vojo Deretic
Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.
April 23, 2018: Current Biology: CB
Tom Bashford, P John Clarkson, David K Menon, Peter J A Hutchinson
No abstract text is available yet for this article.
2018: BMJ Global Health
Weidong Zhang, Houlong L Zhuang, Lei Fan, Lina Gao, Yingying Lu
Dendritic Li deposition has been "a Gordian knot" for almost half a century, which significantly hinders the practical use of high-energy lithium metal batteries (LMBs). The underlying mechanisms of this dendrite formation are related to the preferential lithium deposition on the tips of the protuberances of the anode surface and also associated with the concentration gradient or even depletion of anions during cycling. Therefore, a synergistic regulation of cations and anions at the interface is vital to promoting dendrite-free Li anodes...
February 2018: Science Advances
Joseph L Costello, Michael Schrader
Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells...
February 2018: Current Opinion in Cell Biology
Amy Zhang, Tomoko Y Steen
The Chernobyl and Fukushima nuclear accidents have called forth a growing body of research on their biological aftermaths. A variety of wild organisms, including primates, birds, fish, insects, and worms are being studied in the affected areas, with emerging morphological, physiological, and genetic aberrations ascribed to ionizing radiation. Despite the effort in surveying Chernobyl and Fukushima wildlife, little is known about the microorganisms associated with these radiation-contaminated animals. The microbiota, especially the gut commensal, plays an important role in shaping the metabolic reservoir and immune system of the host, and is sensitive to a wide array of environmental factors, including ionizing radiation...
February 14, 2018: Journal of Heredity
M L Cartter, R Lynfield, K A Feldman, S A Hook, A F Hinckley
Current surveillance methods have been useful to document geographic expansion of Lyme disease in the United States and to monitor the increasing incidence of this major public health problem. Nevertheless, these approaches are resource-intensive, generate results that are difficult to compare across jurisdictions, and measure less than the total burden of disease. By adopting more efficient methods, resources could be diverted instead to education of at-risk populations and new approaches to prevention. In this special issue of Zoonoses and Public Health, seven articles are presented that either evaluate traditional Lyme disease surveillance methods or explore alternatives that have the potential to be less costly, more reliable, and sustainable...
March 2018: Zoonoses and Public Health
Harshad Ghodke, Jacob S Lewis, Antoine M van Oijen
Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.
March 2018: Trends in Biochemical Sciences
Vasiliki Katsi, Georgios Georgiopoulos, Maria Marketou, Dimitrios Oikonomou, Fragiskos Parthenakis, Thomas Makris, Petros Nihoyannopoulos, P Vardas, Dimitris Tousoulis
BACKGROUND: Atrial fibrillation (AF) constitutes a relatively infrequent pregnancy complication, which may be a therapeutic Gordian knot. Indeed, sparse data exist regarding the prevalence, prognosis, and management of AF during pregnancy. In general, AF occurs as a benign, self-limited arrhythmia, but occasionally may have severe hemodynamic consequences in pregnant patients suffering from heart failure, congenital heart disease, or other comorbidities. Extra-cardiac causes of AF should always be meticulously excluded...
August 2017: Current Medical Research and Opinion
Alexandre Fabre, Céline Roman, Bertrand Roquelaure
Despite many years of research, the causes of biliary atresia still remain elusive. Infection, immune disorder, toxins or maternal microchimerism have been cited as potential triggers of biliary atresia. This is a rare disease with a stable incidence over the years although with sizeable ethnic variations. This stability suggests that environmental factors have in fact only a slight influence. During the search for etiologies, twin studies have often helped disentangle the genetic from the environmental. For this condition, twin studies have mainly demonstrated a lack of concordance between twins (either monozygotic or dizygotic), ruling out Mendelian, infectious or toxic causes...
May 2017: Medical Hypotheses
Günter Kirste
No abstract text is available yet for this article.
August 2017: Transplantation
Roberto Nuño Solinís, K Viktoria Stein
No abstract text is available yet for this article.
October 17, 2016: International Journal of Integrated Care
Sen Hee Tay, Anselm Mak
No abstract text is available yet for this article.
May 1, 2017: Rheumatology
Alessandra Bortoluzzi, Carlo A Scirè, Marcello Govoni
No abstract text is available yet for this article.
May 1, 2017: Rheumatology
Vassilis L Tzounakas, Anastasios G Kriebardis, Jerard Seghatchian, Issidora S Papassideri, Marianna H Antonelou
What is following the impressive progress that has been made? During the last couple of years several tremors have shaken the field of Transfusion Medicine. The epicentres of those tremors were located on novel insights into the RBC storage lesion, on emerging connections between storage lesion and post-transfusion performance and effects, and on acknowledging that storage time is only one (rather than the most prominent) of the parameters which contribute to the progression of storage lesion in any given unit of blood...
March 2017: Blood Transfusion, Trasfusione del Sangue
Veronica Lövgren, Urban Markström, Lennart Sauer
This article presents an overview of research about support-to-work in relation to psychiatric and intellectual disabilities. The overview shows that support-to-work services are multifaceted, and that work can be seen as a tool for individual rehabilitation or as a set of goals to achieve. Providers are presented with specific components, which are characterized by systematic, targeted, and individualized interventions. The overview illustrates a need for long-term engagement and cooperation of and between welfare services and agents within the labor market to dissolve the Gordian knot that the transition from welfare interventions to employment seems to be...
January 2017: Journal of Social Work in Disability & Rehabilitation
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