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Gordian knot

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https://www.readbyqxmd.com/read/28498066/atrial-fibrillation-in-pregnancy-a-growing-challenge
#1
Vasiliki Katsi, Georgios Georgiopoulos, Maria Marketou, Dimitrios Oikonomou, Fragiskos Parthenakis, Thomas Makris, Petros Nihoyannopoulos, P Vardas, Dimitris Tousoulis
Atrial fibrillation (AF) constitutes a relatively infrequent pregnancy complication, which may be a therapeutic Gordian knot. Indeed, sparse data exist regarding the prevalence, prognosis and management of AF during pregnancy. In general, AF occurs as a benign, self-limited arrhythmia but occasionally may have severe hemodynamic consequences in pregnant patients suffering from heart failure, congenital heart disease, or other comorbidities. Extra-cardiac causes of AF should always be meticulously excluded. Treatment decisions are difficult, since medications may cross placental barrier and potentially affect fetal growth and organogenesis or even result in fetal bradyarrhythmias...
May 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28478841/somatic-mutation-a-cause-of-biliary-atresia-a-hypothesis
#2
Alexandre Fabre, Céline Roman, Bertrand Roquelaure
Despite many years of research, the causes of biliary atresia still remain elusive. Infection, immune disorder, toxins or maternal microchimerism have been cited as potential triggers of biliary atresia. This is a rare disease with a stable incidence over the years although with sizeable ethnic variations. This stability suggests that environmental factors have in fact only a slight influence. During the search for etiologies, twin studies have often helped disentangle the genetic from the environmental. For this condition, twin studies have mainly demonstrated a lack of concordance between twins (either monozygotic or dizygotic), ruling out Mendelian, infectious or toxic causes...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28437286/cut-the-gordian-knot
#3
Guenter Kirste
No abstract text is available yet for this article.
April 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28435426/measuring-integrated-care-the-quest-for-disentangling-a-gordian-knot
#4
EDITORIAL
Roberto Nuño Solinís, K Viktoria Stein
No abstract text is available yet for this article.
October 17, 2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28340020/comment-on-diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot-reply
#5
Sen Hee Tay, Anselm Mak
No abstract text is available yet for this article.
March 2, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339930/comment-on-diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#6
Alessandra Bortoluzzi, Carlo A Scirè, Marcello Govoni
No abstract text is available yet for this article.
March 2, 2017: Rheumatology
https://www.readbyqxmd.com/read/28263169/unraveling-the-gordian-knot-red-blood-cell-storage-lesion-and-transfusion-outcomes
#7
REVIEW
Vassilis L Tzounakas, Anastasios G Kriebardis, Jerard Seghatchian, Issidora S Papassideri, Marianna H Antonelou
What is following the impressive progress that has been made? During the last couple of years several tremors have shaken the field of Transfusion Medicine. The epicentres of those tremors were located on novel insights into the RBC storage lesion, on emerging connections between storage lesion and post-transfusion performance and effects, and on acknowledging that storage time is only one (rather than the most prominent) of the parameters which contribute to the progression of storage lesion in any given unit of blood...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28187697/towards-employment-what-research-says-about-support-to-work-in-relation-to-psychiatric-and-intellectual-disabilities
#8
Veronica Lövgren, Urban Markström, Lennart Sauer
This article presents an overview of research about support-to-work in relation to psychiatric and intellectual disabilities. The overview shows that support-to-work services are multifaceted, and that work can be seen as a tool for individual rehabilitation or as a set of goals to achieve. Providers are presented with specific components, which are characterized by systematic, targeted, and individualized interventions. The overview illustrates a need for long-term engagement and cooperation of and between welfare services and agents within the labor market to dissolve the Gordian knot that the transition from welfare interventions to employment seems to be...
January 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/28066631/serum-uric-acid-levels-and-cardiovascular-disease-the-gordian-knot
#9
COMMENT
Efrén Martínez-Quintana, Antonio Tugores, Fayna Rodríguez-González
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27981189/untangling-the-gordian-knot-of-hiv-stress-and-cognitive-impairment
#10
REVIEW
Arielle N Valdez, Leah H Rubin, Gretchen N Neigh
As individuals live longer with HIV, this "graying of the HIV epidemic" has introduced a new set of challenges including a growing number of age and inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia. The biological underpinnings of these complex and co-morbid diseases are not fully understood and become very difficult to disentangle in the context of HIV and aging. In the current review we examine the contributions and interactions of HIV, stress, and cognitive impairment and query the extent to which inflammation is the linchpin in these dynamic interactions...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27903936/operationalising-cognitive-fatigability-in-multiple-sclerosis-a-gordian-knot-that-can-be-cut
#11
Anthony Mark Harrison, Roshan das Nair, Rona Moss-Morris
BACKGROUND: Researchers have attempted to operationalise objective measures of cognitive fatigability in multiple sclerosis (MS) to overcome the perceived subjectivity of patient-reported outcomes of fatigue (PROs). Measures of cognitive fatigability examine decrements in performance during sustained neurocognitive tasks. OBJECTIVE: This personal viewpoint briefly summarises available evidence for measures of cognitive fatigability in MS and considers their overall utility...
November 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27894950/untying-the-gordian-knot-of-pericardial-diseases-a-pragmatic-approach
#12
REVIEW
George Lazaros, Massimo Imazio, Antonio Brucato, Dimitrios Tousoulis
Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, especially the idiopathic forms that are the most prevalent, is considered a benign disease overall, its short- and long-term complications, namely, recurrent pericarditis, cardiac tamponade and constrictive pericarditis, constitute a matter of concern in the medical community. In recent years, several clinical trials contributed to redefining our traditional approach to pericardial diseases. In this review, we provide the most recent evidence concerning diagnosis, treatment modalities and short- and long-term prognosis of the most common pericardial disorders...
September 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27744358/diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#13
Sen Hee Tay, Anselm Mak
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events...
April 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27614448/could-crispr-be-the-solution-for-gene-editing-s-gordian-knot
#14
Hao Fang, William Wang
No abstract text is available yet for this article.
September 10, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27531447/reconceptualizing-retirement-a-status-based-approach
#15
David B Hershenson
The one thing on which essentially all retirement scholars agree is that there is no generally accepted definition of the term "retirement." Hence, it is not surprising that a plethora of competing models of the stages of retirement has been generated. To cut this Gordian knot, this paper proposes that the concept of statuses, which are not necessarily mutually exclusive or sequential, replace the idea of stages. Statuses better reflect observed human behavior and are more open to multicultural application, thus facilitating retirement research and clinical practice...
August 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27506735/immune-therapy-in-type-1-diabetes-mellitus-attempts-to-untie-the-gordian-knot
#16
EDITORIAL
Nikolaos Perakakis, Christos S Mantzoros
No abstract text is available yet for this article.
September 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27501258/human-cytomegalovirus-latency-approaching-the-gordian-knot
#17
Felicia Goodrum
Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus (CMV), the prototypical betaherpesvirus, is particularly complex in the host organism. Depending on host physiology and the cell types infected, CMV persistence comprises latent, chronic, and productive states that may occur concurrently. Viral latency is a central strategy by which herpesviruses ensure their lifelong persistence. Although much remains to be defined about the virus-host interactions important to CMV latency, it is clear that checkpoints composed of viral and cellular factors exist to either maintain a latent state or initiate productive replication in response to host cues...
September 29, 2016: Annual Review of Virology
https://www.readbyqxmd.com/read/27373232/a-gordian-knot-disentangling-comorbidities-in-heart-failure
#18
EDITORIAL
Nancy Luo, Robert J Mentz
No abstract text is available yet for this article.
July 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27144298/integrating-early-intervention-for-borderline-personality-disorder-and-mood-disorders
#19
Andrew M Chanen, Michael Berk, Katherine Thompson
Borderline personality disorder (BPD) has been demonstrated to be a reliable and valid construct in young people (adolescents and young adults). Both borderline- and mood-related psychopathology become clinically apparent from puberty through to young adulthood, frequently co-occur, can reinforce one another, and can be difficult to differentiate clinically. This Gordian knot of overlapping clinical features, common risk factors, and precursors to both BPD and mood disorders complicates clinical assessment, prevention, and treatment...
September 2016: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/27114429/helicobacter-pylori-eradication-a-gordian-knot-for-idiopathic-thrombocytopenic-purpura
#20
EDITORIAL
Tae Ho Kim, Dae Young Cheung
No abstract text is available yet for this article.
May 23, 2016: Gut and Liver
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