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Gordian knot

Sen Hee Tay, Anselm Mak
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events...
October 15, 2016: Rheumatology
Hao Fang, William Wang
No abstract text is available yet for this article.
September 10, 2016: Cell Biology and Toxicology
David B Hershenson
The one thing on which essentially all retirement scholars agree is that there is no generally accepted definition of the term "retirement." Hence, it is not surprising that a plethora of competing models of the stages of retirement has been generated. To cut this Gordian knot, this paper proposes that the concept of statuses, which are not necessarily mutually exclusive or sequential, replace the idea of stages. Statuses better reflect observed human behavior and are more open to multicultural application, thus facilitating retirement research and clinical practice...
August 2016: Journal of Aging Studies
Nikolaos Perakakis, Christos S Mantzoros
No abstract text is available yet for this article.
September 2016: Metabolism: Clinical and Experimental
Felicia Goodrum
Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus (CMV), the prototypical betaherpesvirus, is particularly complex in the host organism. Depending on host physiology and the cell types infected, CMV persistence comprises latent, chronic, and productive states that may occur concurrently. Viral latency is a central strategy by which herpesviruses ensure their lifelong persistence. Although much remains to be defined about the virus-host interactions important to CMV latency, it is clear that checkpoints composed of viral and cellular factors exist to either maintain a latent state or initiate productive replication in response to host cues...
September 29, 2016: Annual Review of Virology
Nancy Luo, Robert J Mentz
No abstract text is available yet for this article.
July 2016: European Journal of Heart Failure
Andrew M Chanen, Michael Berk, Katherine Thompson
Borderline personality disorder (BPD) has been demonstrated to be a reliable and valid construct in young people (adolescents and young adults). Both borderline- and mood-related psychopathology become clinically apparent from puberty through to young adulthood, frequently co-occur, can reinforce one another, and can be difficult to differentiate clinically. This Gordian knot of overlapping clinical features, common risk factors, and precursors to both BPD and mood disorders complicates clinical assessment, prevention, and treatment...
September 2016: Harvard Review of Psychiatry
Tae Ho Kim, Dae Young Cheung
No abstract text is available yet for this article.
May 23, 2016: Gut and Liver
Mayan Amiezer, Tri Giang Phan
T follicular regulatory (Tfr) cells are a subpopulation of Treg cells that have adopted the T follicular helper cell program to localize to the B-cell follicle. Because of the difficulties in generating mouse models in which Tfr cells are selectively affected, determining where and how Tfr cells regulate the germinal center response remains to be resolved. In this issue of the European Journal of Immunology, Dent and colleagues [Eur. J. Immunol. 2016. 46: 1152-1161] describe a simple, elegant mouse model to conditionally delete Tfr cells without impacting on the Treg- and Tfh-cell populations...
May 2016: European Journal of Immunology
Shih-Chi Lou, Svava Wetzel, Hongyu Zhang, Elizabeth W Crone, Yun-Tzai Lee, Sophie E Jackson, Shang-Te Danny Hsu
The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant neuronal deubiquitinase that is associated with Parkinson's disease. It contains a complex Gordian knot topology formed by the polypeptide chain alone. Using a combination of fluorescence-based kinetic measurements, we show that UCH-L1 has two distinct kinetic folding intermediates that are transiently populated on parallel pathways between the denatured and native states. NMR hydrogen-deuterium exchange (HDX) experiments indicate the presence of partially unfolded forms (PUFs) of UCH-L1 under native conditions...
June 5, 2016: Journal of Molecular Biology
Antonino Naro, Placido Bramanti, Antonino Leo, Margherita Russo, Rocco Salvatore Calabrò
Unresponsive wakefulness syndrome (UWS) is a chronic disorder of consciousness (DOC) characterized by a lack of awareness and purposeful motor behaviors, owing to an extensive brain connectivity impairment. Nevertheless, some UWS patients may retain residual brain connectivity patterns, which may sustain a covert awareness, namely functional locked-in syndrome (fLIS). We evaluated the possibility of bringing to light such residual neural networks using a non-invasive neurostimulation protocol. To this end, we enrolled 15 healthy individuals and 26 DOC patients (minimally conscious state-MCS- and UWS), who underwent a γ-band transcranial alternating current stimulation (tACS) over the right dorsolateral prefrontal cortex...
July 2016: Brain Topography
Eugene Z Oddone, L Ebony Boulware
Primary care is the cornerstone of effective and efficient healthcare systems. Patients prefer a trusted primary care provider to serve as the first contact for all of their healthcare questions, to help them make important health decisions, to help guide them through an expanding amount of medical information and to help coordinate their care with all other providers. Patients also prefer to establish an ongoing, continuous relationship with their primary care provider. However, fewer and fewer physicians are choosing primary care as a career, threatening the foundation of the health system...
January 2016: American Journal of the Medical Sciences
Patrick McEvoy
No abstract text is available yet for this article.
December 2015: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Evangeli S Lampri, Georgios Chondrogiannis, Elli Ioachim, Anna Varouktsi, Antigoni Mitselou, Aggeliki Galani, Evangelos Briassoulis, Panagiotis Kanavaros, Vasiliki Galani
Head and neck tumors comprise a wide spectrum of heterogeneous neoplasms for which biomarkers are needed to aid in earlier diagnosis, risk assessment and therapy response. Personalized medicine based on predictive markers linked to drug response, it is hoped, will lead to improvements in outcomes and avoidance of unnecessary treatment in carcinoma of the head and neck. Because of the heterogeneity of head and neck tumors, the integration of multiple selected markers in association with the histopathologic features is advocated for risk assessment...
2015: International Journal of Clinical and Experimental Medicine
Jannick Kappelmann, Wolfgang Wiechert, Stephan Noack
Corynebacterium glutamicum is the major workhorse for the microbial production of several amino and organic acids. As long as these derive from tricarboxylic acid cycle intermediates, the activity of anaplerotic reactions is pivotal for a high biosynthetic yield. To determine single anaplerotic activities (13) C-Metabolic Flux Analysis ((13) C-MFA) has been extensively used for C. glutamicum, however with different network topologies, inconsistent or poorly determined anaplerotic reaction rates. Therefore, in this study we set out to investigate whether a focused isotopomer model of the anaplerotic node can at all admit a unique solution for all fluxes...
March 2016: Biotechnology and Bioengineering
Jörg Tomeczkowski, Ansgar Lange, Andreas Güntert, Pushpike Thilakarathne, Joris Diels, Liang Xiu, Peter De Porre, Christoph Tapprich
INTRODUCTION: Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen(®) (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment choice (TC): at primary analysis the hazard ratio (HR) was 0.85 (95% confidence interval 0.69-1.04; stratified log-rank P = 0.108). With two interim analyses, two-sided alpha was adjusted to 0.0462. With 1-year additional follow-up the HR reached 0.82 (nominal P = 0.0373)...
September 2015: Advances in Therapy
Ralph R Turner, Christopher Landon
No abstract text is available yet for this article.
September 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Olga Ponomarova, Kiran Raosaheb Patil
Metabolic exchanges are ubiquitous in microbial communities. However, detecting metabolite cross-feedings is difficult due to their intrinsically dynamic nature and the complexity of communities. Thus, while exhaustive description of metabolic networks operating in natural systems is a task for the future, the battle of today is divided between detailed characterizations of small, reduced complexity microbial consortia, and focusing on particular metabolic aspects of natural ecosystems. Detecting metabolic interactions requires methodological blend able to capture species identity, dependencies and the nature of exchanged metabolites...
October 2015: Current Opinion in Microbiology
Yao-Jun Zhang, Dao-Rong Pan, Si Pang, Wen Wu, Bo Xu
No abstract text is available yet for this article.
July 2015: EuroIntervention
George Giannakoulas, Maria Boutsikou
No abstract text is available yet for this article.
October 2015: Heart: Official Journal of the British Cardiac Society
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