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Gordian knot

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https://www.readbyqxmd.com/read/29607105/unpicking-the-gordian-knot-a-systems-approach-to-traumatic-brain-injury-care-in-low-income-and-middle-income-countries
#1
Tom Bashford, P John Clarkson, David K Menon, Peter J A Hutchinson
No abstract text is available yet for this article.
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29507888/a-cation-anion-regulation-synergistic-anode-host-for-dendrite-free-lithium-metal-batteries
#2
Weidong Zhang, Houlong L Zhuang, Lei Fan, Lina Gao, Yingying Lu
Dendritic Li deposition has been "a Gordian knot" for almost half a century, which significantly hinders the practical use of high-energy lithium metal batteries (LMBs). The underlying mechanisms of this dendrite formation are related to the preferential lithium deposition on the tips of the protuberances of the anode surface and also associated with the concentration gradient or even depletion of anions during cycling. Therefore, a synergistic regulation of cations and anions at the interface is vital to promoting dendrite-free Li anodes...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29475136/unloosing-the-gordian-knot-of-peroxisome-formation
#3
REVIEW
Joseph L Costello, Michael Schrader
Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells...
February 20, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29452420/gut-microbiomics-a-solution-to-unloose-the-gordian-knot-of-biological-effects-of-ionizing-radiation
#4
Amy Zhang, Tomoko Y Steen
The Chernobyl and Fukushima nuclear accidents have called forth a growing body of research on their biological aftermaths. A variety of wild organisms, including primates, birds, fish, insects, and worms are being studied in the affected areas, with emerging morphological, physiological, and genetic aberrations ascribed to ionizing radiation. Despite the effort in surveying Chernobyl and Fukushima wildlife, little is known about the microorganisms associated with these radiation-contaminated animals. The microbiota, especially the gut commensal, plays an important role in shaping the metabolic reservoir and immune system of the host, and is sensitive to a wide array of environmental factors, including ionizing radiation...
February 14, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29431297/lyme-disease-surveillance-in-the-united-states-looking-for-ways-to-cut-the-gordian-knot
#5
M L Cartter, R Lynfield, K A Feldman, S A Hook, A F Hinckley
Current surveillance methods have been useful to document geographic expansion of Lyme disease in the United States and to monitor the increasing incidence of this major public health problem. Nevertheless, these approaches are resource-intensive, generate results that are difficult to compare across jurisdictions, and measure less than the total burden of disease. By adopting more efficient methods, resources could be diverted instead to education of at-risk populations and new approaches to prevention. In this special issue of Zoonoses and Public Health, seven articles are presented that either evaluate traditional Lyme disease surveillance methods or explore alternatives that have the potential to be less costly, more reliable, and sustainable...
March 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29290471/resolving-the-gordian-knot-srs2-strips-intermediates-formed-during-homologous-recombination
#6
Harshad Ghodke, Jacob S Lewis, Antoine M van Oijen
Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular steps involved. De Tullio et al. and Kaniecki et al. watch individual Srs2 helicase molecules disrupt repair intermediates formed by RPA, Rad51, and Rad52 on DNA during homologous recombination.
March 2018: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28498066/atrial-fibrillation-in-pregnancy-a-growing-challenge
#7
Vasiliki Katsi, Georgios Georgiopoulos, Maria Marketou, Dimitrios Oikonomou, Fragiskos Parthenakis, Thomas Makris, Petros Nihoyannopoulos, P Vardas, Dimitris Tousoulis
BACKGROUND: Atrial fibrillation (AF) constitutes a relatively infrequent pregnancy complication, which may be a therapeutic Gordian knot. Indeed, sparse data exist regarding the prevalence, prognosis, and management of AF during pregnancy. In general, AF occurs as a benign, self-limited arrhythmia, but occasionally may have severe hemodynamic consequences in pregnant patients suffering from heart failure, congenital heart disease, or other comorbidities. Extra-cardiac causes of AF should always be meticulously excluded...
August 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28478841/somatic-mutation-a-cause-of-biliary-atresia-a-hypothesis
#8
Alexandre Fabre, Céline Roman, Bertrand Roquelaure
Despite many years of research, the causes of biliary atresia still remain elusive. Infection, immune disorder, toxins or maternal microchimerism have been cited as potential triggers of biliary atresia. This is a rare disease with a stable incidence over the years although with sizeable ethnic variations. This stability suggests that environmental factors have in fact only a slight influence. During the search for etiologies, twin studies have often helped disentangle the genetic from the environmental. For this condition, twin studies have mainly demonstrated a lack of concordance between twins (either monozygotic or dizygotic), ruling out Mendelian, infectious or toxic causes...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28437286/cut-the-gordian-knot
#9
Guenter Kirste
No abstract text is available yet for this article.
April 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28435426/measuring-integrated-care-the-quest-for-disentangling-a-gordian-knot
#10
EDITORIAL
Roberto Nuño Solinís, K Viktoria Stein
No abstract text is available yet for this article.
October 17, 2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28340020/comment-on-diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot-reply
#11
Sen Hee Tay, Anselm Mak
No abstract text is available yet for this article.
May 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339930/comment-on-diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#12
Alessandra Bortoluzzi, Carlo A Scirè, Marcello Govoni
No abstract text is available yet for this article.
May 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28263169/unraveling-the-gordian-knot-red-blood-cell-storage-lesion-and-transfusion-outcomes
#13
REVIEW
Vassilis L Tzounakas, Anastasios G Kriebardis, Jerard Seghatchian, Issidora S Papassideri, Marianna H Antonelou
What is following the impressive progress that has been made? During the last couple of years several tremors have shaken the field of Transfusion Medicine. The epicentres of those tremors were located on novel insights into the RBC storage lesion, on emerging connections between storage lesion and post-transfusion performance and effects, and on acknowledging that storage time is only one (rather than the most prominent) of the parameters which contribute to the progression of storage lesion in any given unit of blood...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28187697/towards-employment-what-research-says-about-support-to-work-in-relation-to-psychiatric-and-intellectual-disabilities
#14
REVIEW
Veronica Lövgren, Urban Markström, Lennart Sauer
This article presents an overview of research about support-to-work in relation to psychiatric and intellectual disabilities. The overview shows that support-to-work services are multifaceted, and that work can be seen as a tool for individual rehabilitation or as a set of goals to achieve. Providers are presented with specific components, which are characterized by systematic, targeted, and individualized interventions. The overview illustrates a need for long-term engagement and cooperation of and between welfare services and agents within the labor market to dissolve the Gordian knot that the transition from welfare interventions to employment seems to be...
January 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/28066631/serum-uric-acid-levels-and-cardiovascular-disease-the-gordian-knot
#15
COMMENT
Efrén Martínez-Quintana, Antonio Tugores, Fayna Rodríguez-González
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27981189/untangling-the-gordian-knot-of-hiv-stress-and-cognitive-impairment
#16
REVIEW
Arielle N Valdez, Leah H Rubin, Gretchen N Neigh
As individuals live longer with HIV, this "graying of the HIV epidemic" has introduced a new set of challenges including a growing number of age and inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia. The biological underpinnings of these complex and co-morbid diseases are not fully understood and become very difficult to disentangle in the context of HIV and aging. In the current review we examine the contributions and interactions of HIV, stress, and cognitive impairment and query the extent to which inflammation is the linchpin in these dynamic interactions...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27903936/operationalising-cognitive-fatigability-in-multiple-sclerosis-a-gordian-knot-that-can-be-cut
#17
Anthony Mark Harrison, Roshan das Nair, Rona Moss-Morris
BACKGROUND: Researchers have attempted to operationalise objective measures of cognitive fatigability in multiple sclerosis (MS) to overcome the perceived subjectivity of patient-reported outcomes of fatigue (PROs). Measures of cognitive fatigability examine decrements in performance during sustained neurocognitive tasks. OBJECTIVE: This personal viewpoint briefly summarises available evidence for measures of cognitive fatigability in MS and considers their overall utility...
November 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27894950/untying-the-gordian-knot-of-pericardial-diseases-a-pragmatic-approach
#18
REVIEW
George Lazaros, Massimo Imazio, Antonio Brucato, Dimitrios Tousoulis
Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, especially the idiopathic forms that are the most prevalent, is considered a benign disease overall, its short- and long-term complications, namely, recurrent pericarditis, cardiac tamponade and constrictive pericarditis, constitute a matter of concern in the medical community. In recent years, several clinical trials contributed to redefining our traditional approach to pericardial diseases. In this review, we provide the most recent evidence concerning diagnosis, treatment modalities and short- and long-term prognosis of the most common pericardial disorders...
September 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27744358/diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#19
REVIEW
Sen Hee Tay, Anselm Mak
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events...
April 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27614448/could-crispr-be-the-solution-for-gene-editing-s-gordian-knot
#20
Hao Fang, William Wang
No abstract text is available yet for this article.
September 10, 2016: Cell Biology and Toxicology
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