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https://www.readbyqxmd.com/read/28187697/towards-employment-what-research-says-about-support-to-work-in-relation-to-psychiatric-and-intellectual-disabilities
#1
Veronica Lövgren, Urban Markström, Lennart Sauer
This article presents an overview of research about support-to-work in relation to psychiatric and intellectual disabilities. The overview shows that support-to-work services are multifaceted, and that work can be seen as a tool for individual rehabilitation or as a set of goals to achieve. Providers are presented with specific components, which are characterized by systematic, targeted, and individualized interventions. The overview illustrates a need for long-term engagement and cooperation of and between welfare services and agents within the labor market to dissolve the Gordian knot that the transition from welfare interventions to employment seems to be...
January 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/28066631/serum-uric-acid-levels-and-cardiovascular-disease-the-gordian-knot
#2
COMMENT
Efrén Martínez-Quintana, Antonio Tugores, Fayna Rodríguez-González
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27981189/untangling-the-gordian-knot-of-hiv-stress-and-cognitive-impairment
#3
REVIEW
Arielle N Valdez, Leah H Rubin, Gretchen N Neigh
As individuals live longer with HIV, this "graying of the HIV epidemic" has introduced a new set of challenges including a growing number of age and inflammation-related diseases such as cardiovascular disease, type II diabetes, cancer, and dementia. The biological underpinnings of these complex and co-morbid diseases are not fully understood and become very difficult to disentangle in the context of HIV and aging. In the current review we examine the contributions and interactions of HIV, stress, and cognitive impairment and query the extent to which inflammation is the linchpin in these dynamic interactions...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27903936/operationalising-cognitive-fatigability-in-multiple-sclerosis-a-gordian-knot-that-can-be-cut
#4
Anthony Mark Harrison, Roshan das Nair, Rona Moss-Morris
BACKGROUND: Researchers have attempted to operationalise objective measures of cognitive fatigability in multiple sclerosis (MS) to overcome the perceived subjectivity of patient-reported outcomes of fatigue (PROs). Measures of cognitive fatigability examine decrements in performance during sustained neurocognitive tasks. OBJECTIVE: This personal viewpoint briefly summarises available evidence for measures of cognitive fatigability in MS and considers their overall utility...
November 30, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27894950/untying-the-gordian-knot-of-pericardial-diseases-a-pragmatic-approach
#5
REVIEW
George Lazaros, Massimo Imazio, Antonio Brucato, Dimitrios Tousoulis
Pericardial disorders constitute a relatively common cause of heart disease. Although acute pericarditis, especially the idiopathic forms that are the most prevalent, is considered a benign disease overall, its short- and long-term complications, namely, recurrent pericarditis, cardiac tamponade and constrictive pericarditis, constitute a matter of concern in the medical community. In recent years, several clinical trials contributed to redefining our traditional approach to pericardial diseases. In this review, we provide the most recent evidence concerning diagnosis, treatment modalities and short- and long-term prognosis of the most common pericardial disorders...
November 25, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27744358/diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#6
REVIEW
Sen Hee Tay, Anselm Mak
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events...
October 15, 2016: Rheumatology
https://www.readbyqxmd.com/read/27614448/could-crispr-be-the-solution-for-gene-editing-s-gordian-knot
#7
Hao Fang, William Wang
No abstract text is available yet for this article.
September 10, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27531447/reconceptualizing-retirement-a-status-based-approach
#8
David B Hershenson
The one thing on which essentially all retirement scholars agree is that there is no generally accepted definition of the term "retirement." Hence, it is not surprising that a plethora of competing models of the stages of retirement has been generated. To cut this Gordian knot, this paper proposes that the concept of statuses, which are not necessarily mutually exclusive or sequential, replace the idea of stages. Statuses better reflect observed human behavior and are more open to multicultural application, thus facilitating retirement research and clinical practice...
August 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27506735/immune-therapy-in-type-1-diabetes-mellitus-attempts-to-untie-the-gordian-knot
#9
EDITORIAL
Nikolaos Perakakis, Christos S Mantzoros
No abstract text is available yet for this article.
September 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27501258/human-cytomegalovirus-latency-approaching-the-gordian-knot
#10
Felicia Goodrum
Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus (CMV), the prototypical betaherpesvirus, is particularly complex in the host organism. Depending on host physiology and the cell types infected, CMV persistence comprises latent, chronic, and productive states that may occur concurrently. Viral latency is a central strategy by which herpesviruses ensure their lifelong persistence. Although much remains to be defined about the virus-host interactions important to CMV latency, it is clear that checkpoints composed of viral and cellular factors exist to either maintain a latent state or initiate productive replication in response to host cues...
September 29, 2016: Annual Review of Virology
https://www.readbyqxmd.com/read/27373232/a-gordian-knot-disentangling-comorbidities-in-heart-failure
#11
EDITORIAL
Nancy Luo, Robert J Mentz
No abstract text is available yet for this article.
July 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27144298/integrating-early-intervention-for-borderline-personality-disorder-and-mood-disorders
#12
Andrew M Chanen, Michael Berk, Katherine Thompson
Borderline personality disorder (BPD) has been demonstrated to be a reliable and valid construct in young people (adolescents and young adults). Both borderline- and mood-related psychopathology become clinically apparent from puberty through to young adulthood, frequently co-occur, can reinforce one another, and can be difficult to differentiate clinically. This Gordian knot of overlapping clinical features, common risk factors, and precursors to both BPD and mood disorders complicates clinical assessment, prevention, and treatment...
September 2016: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/27114429/helicobacter-pylori-eradication-a-gordian-knot-for-idiopathic-thrombocytopenic-purpura
#13
EDITORIAL
Tae Ho Kim, Dae Young Cheung
No abstract text is available yet for this article.
May 23, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27109022/disentangling-tfr-cells-from-treg-cells-and-tfh-cells-how-to-untie-the-gordian-knot
#14
Mayan Amiezer, Tri Giang Phan
T follicular regulatory (Tfr) cells are a subpopulation of Treg cells that have adopted the T follicular helper cell program to localize to the B-cell follicle. Because of the difficulties in generating mouse models in which Tfr cells are selectively affected, determining where and how Tfr cells regulate the germinal center response remains to be resolved. In this issue of the European Journal of Immunology, Dent and colleagues [Eur. J. Immunol. 2016. 46: 1152-1161] describe a simple, elegant mouse model to conditionally delete Tfr cells without impacting on the Treg- and Tfh-cell populations...
May 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27067109/the-knotted-protein-uch-l1-exhibits-partially-unfolded-forms-under-native-conditions-that-share-common-structural-features-with-its-kinetic-folding-intermediates
#15
Shih-Chi Lou, Svava Wetzel, Hongyu Zhang, Elizabeth W Crone, Yun-Tzai Lee, Sophie E Jackson, Shang-Te Danny Hsu
The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant neuronal deubiquitinase that is associated with Parkinson's disease. It contains a complex Gordian knot topology formed by the polypeptide chain alone. Using a combination of fluorescence-based kinetic measurements, we show that UCH-L1 has two distinct kinetic folding intermediates that are transiently populated on parallel pathways between the denatured and native states. NMR hydrogen-deuterium exchange (HDX) experiments indicate the presence of partially unfolded forms (PUFs) of UCH-L1 under native conditions...
June 5, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27062669/transcranial-alternating-current-stimulation-in-patients-with-chronic-disorder-of-consciousness-a-possible-way-to-cut-the-diagnostic-gordian-knot
#16
Antonino Naro, Placido Bramanti, Antonino Leo, Margherita Russo, Rocco Salvatore Calabrò
Unresponsive wakefulness syndrome (UWS) is a chronic disorder of consciousness (DOC) characterized by a lack of awareness and purposeful motor behaviors, owing to an extensive brain connectivity impairment. Nevertheless, some UWS patients may retain residual brain connectivity patterns, which may sustain a covert awareness, namely functional locked-in syndrome (fLIS). We evaluated the possibility of bringing to light such residual neural networks using a non-invasive neurostimulation protocol. To this end, we enrolled 15 healthy individuals and 26 DOC patients (minimally conscious state-MCS- and UWS), who underwent a γ-band transcranial alternating current stimulation (tACS) over the right dorsolateral prefrontal cortex...
July 2016: Brain Topography
https://www.readbyqxmd.com/read/26802754/primary-care-medicine-s-gordian-knot
#17
Eugene Z Oddone, L Ebony Boulware
Primary care is the cornerstone of effective and efficient healthcare systems. Patients prefer a trusted primary care provider to serve as the first contact for all of their healthcare questions, to help them make important health decisions, to help guide them through an expanding amount of medical information and to help coordinate their care with all other providers. Patients also prefer to establish an ongoing, continuous relationship with their primary care provider. However, fewer and fewer physicians are choosing primary care as a career, threatening the foundation of the health system...
January 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/26622011/euthanasia-ethics-and-the-gordian-knot-is-the-hippocratic-code-obsolete
#18
EDITORIAL
Patrick McEvoy
No abstract text is available yet for this article.
December 2015: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/26379825/biomarkers-of-head-and-neck-cancer-tools-or-a-gordian-knot
#19
REVIEW
Evangeli S Lampri, Georgios Chondrogiannis, Elli Ioachim, Anna Varouktsi, Antigoni Mitselou, Aggeliki Galani, Evangelos Briassoulis, Panagiotis Kanavaros, Vasiliki Galani
Head and neck tumors comprise a wide spectrum of heterogeneous neoplasms for which biomarkers are needed to aid in earlier diagnosis, risk assessment and therapy response. Personalized medicine based on predictive markers linked to drug response, it is hoped, will lead to improvements in outcomes and avoidance of unnecessary treatment in carcinoma of the head and neck. Because of the heterogeneity of head and neck tumors, the integration of multiple selected markers in association with the histopathologic features is advocated for risk assessment...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26375179/cutting-the-gordian-knot-identifiability-of-anaplerotic-reactions-in-corynebacterium-glutamicum-by-means-of-13-c-metabolic-flux-analysis
#20
Jannick Kappelmann, Wolfgang Wiechert, Stephan Noack
Corynebacterium glutamicum is the major workhorse for the microbial production of several amino and organic acids. As long as these derive from tricarboxylic acid cycle intermediates, the activity of anaplerotic reactions is pivotal for a high biosynthetic yield. To determine single anaplerotic activities (13) C-Metabolic Flux Analysis ((13) C-MFA) has been extensively used for C. glutamicum, however with different network topologies, inconsistent or poorly determined anaplerotic reaction rates. Therefore, in this study we set out to investigate whether a focused isotopomer model of the anaplerotic node can at all admit a unique solution for all fluxes...
March 2016: Biotechnology and Bioengineering
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