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TnT hs Shock

Guy Furniss, Bijia Shi, Alejandro Jimenez, Scott A Harding, Peter D Larsen
AIMS: Previous studies have reported the defibrillation testing during implantable cardioverter defibrillator (ICD) implantation is associated with elevated cardiac biomarkers and ST-segment electrocardiogram (ECG) changes suggesting that shocks during testing may cause harm. However, the effects of testing have not been isolated from the implant procedure itself, where lead deployment may cause myocardial damage. This prospective study examined high sensitivity troponin T (hs-TnT) levels and ECG changes during ICD implanting alone, ICD implantation with testing and device testing as a stand-alone procedure...
February 2015: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Tom Kai Ming Wang, Timothy A C Snow, Yang Chen, Hussam Rostom, Jonathon M White, James T Stewart, Mark W I Webster, Peter N Ruygrok, Timothy Watson, Harvey D White
BACKGROUND: Cardiac troponins are the preferred biomarkers for diagnosing myocardial infarction (MI). High-sensitivity troponin T (hs-TnT) assays have increased sensitivity and enable more rapid diagnosis of infarction. We assessed the prognostic utility of admission hs-TnT to detect outcomes after primary angioplasty for ST-elevation/new left bundle branch block myocardial infarction (STEMI). METHODS: Patients admitted to Auckland City Hospital for acute coronary catheterization with a diagnosis of STEMI between October 2010 and September 2011 were identified, and included if hs-TnT levels were measured at admission...
June 2014: European Heart Journal. Acute Cardiovascular Care
Jan P Roesner, Peter Petzelbauer, Alexander Koch, Nguyen Tran, Thomas Iber, Dierk A Vagts, Thomas W L Scheeren, Brigitte Vollmar, Gabriele E F Nöldge-Schomburg, Kai Zacharowski
OBJECTIVE: The fibrin-derived peptide Bbeta15-42 (also called FX06) has been shown to reduce myocardial infarct size following ischemia/reperfusion. Hemorrhagic shock (HS) followed by volume resuscitation represents a similar scenario, whereby a whole organism is vulnerable to reperfusion injury. DESIGN: We subjected male farm-bred landrace pigs ( approximately 30 kg) to HS by withdrawing blood to a mean arterial pressure of 40 mm Hg for 60 minutes. Pigs were then resuscitated with shed blood and crystalloids for 60 minutes, and at this time, FX06 (2...
February 2009: Critical Care Medicine
Luigi M Biasucci, Giovanna Liuzzo, Alessandra Ciervo, Andrea Petrucca, Maddalena Piro, Dominick J Angiolillo, Filippo Crea, Antonio Cassone, Attilio Maseri
BACKGROUND: Heat shock proteins (HSPs) are a family of proteins with immunogenic and proinflammatory properties. Human and Chlamydia pneumoniae (Cp) HSP60 were found in patients with stable coronary disease. METHODS AND RESULTS: We measured the levels of anti-Cp-HSP60 and anti-Cp immunoglobulin G (IgG) in 179 patients with unstable angina, 40 with acute myocardial infarction, and 40 with stable angina (SA), as well as 100 control subjects. Forty-one patients with acute coronary syndromes (ACS) were also studied at follow-up...
June 24, 2003: Circulation
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