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https://www.readbyqxmd.com/read/29352441/utility-of-tumor-burden-score-to-stratify-prognosis-of-patients-with-hepatocellular-cancer-results-of-4759-cases-from-ita-li-ca-study-group
#1
Alessandro Vitale, Quirino Lai, Fabio Farinati, Laura Bucci, Edoardo G Giannini, Lucia Napoli, Francesca Ciccarese, Gian Lodovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Giuseppe Cabibbo, Roberto Virdone, Fabio Marra, Martina Felder, Filomena Morisco, Luisa Benvegnù, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Antonio Colecchia, Mauro Bernardi, Franco Trevisani, Timothy M Pawlik
BACKGROUND: Dichotomous models like Milan Criteria represent the routinely used tools for predicting the outcome of patients with hepatocellular carcinoma (HCC). However, a paradigm shift from a dichotomous to continuous prognostic stratification should represent a good strategy for improving the prediction process. Recently, the tumor burden score (TBS) has been proposed for selecting patients with colorectal liver metastases. To date, TBS has not been validated in a large HCC population...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352111/hepatic-smarca4-predicts-hcc-recurrence-and-promotes-tumour-cell-proliferation-by-regulating-smad6-expression
#2
Zhiao Chen, Xinyuan Lu, Deshui Jia, Ying Jing, Di Chen, Qifeng Wang, Fangyu Zhao, Jinjun Li, Ming Yao, Wenming Cong, Xianghuo He
Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is typically diagnosed at advanced stages. Identification and characterisation of genes within amplified and deleted chromosomal loci can provide new insights into the pathogenesis of cancer and lead to new approaches for diagnosis and therapy. In our previous study, we found a recurrent region of copy number amplification at 19p13.2 in hepatocellular carcinoma (HCC). In the present study, we performed integrated copy number analysis and expression profiling at this locus and a putative cancer gene, SMARCA4/BRG1, was uncovered in this region...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29350774/hepatitis-b-virus-surface-gene-pre-s2-mutant-as-a-high-risk-serum-marker-for-hepatoma-recurrence-after-curative-hepatic-resection
#3
Chia-Jui Yen, Yu-Lin Ai, Hung-Wen Tsai, Shih-Huang Chan, Chia-Sheng Yen, Kuang-Hsiung Cheng, Yun-Ping Lee, Chia-Wei Kao, Yu-Chun Wang, Yi-Lin Chen, Cheng-Han Lin, Tsunglin Liu, Huey-Pin Tsai, Jen-Ren Wang, Ih-Jen Su, Wenya Huang
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S2 mutant large HBV surface antigen (LHBS) is highly associated with HCC. This study aimed to analyze the expression of the large form of surface protein in tumors and to evaluate the LHBS with mutations within the pre-S2 region as a high-risk recurrence marker in HCC patients after curative hepatic resection. By the analyses of immunohistochemical staining (N = 12) and Western Blotting (N = 22), the HBV surface protein, which is mainly comprised of the major form of HBS, was greatly diminished in the tumors...
January 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29340726/prognostic-prediction-models-for-resection-of-large-hepatocellular-carcinoma-a-korean-multicenter-study
#4
Shin Hwang, Jae-Won Joh, Hee Jung Wang, Dong Goo Kim, Kyung Sik Kim, Kyung-Suk Suh, Seong Hoon Kim, Hee Chul Yu, Chol Kyoon Cho, Young-Joo Lee, Ki-Hun Kim, Jong Man Kim, Bong-Wan Kim, Sung-Gyu Lee
BACKGROUND: We developed a prognostic prediction model (PPM) using 4 factors for hepatic resection (HR) of large hepatic cellular carcinoma (HCC). Multiplication of α-fetoprotein (AFP), des-γ-carboxy prothrombin, and tumor volume (TV) (ADV score) is a surrogate marker for post-resection prognosis. This study intended to validate the predictive power of 4-factor PPM and to develop new ADV score-based PPM. METHODS: A total of 526 patients who underwent HR for solitary HCC ≥ 8 cm were selected from 9 Korean institutions between 2008 and 2014...
January 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29340126/hepatosplenic-gamma-delta-t-cell-lymphoma-hsgdtcl-two-rare-case-reports-from-western-india
#5
Irappa Madabhavi, Gaurang Modi, Harsha Panchal, Apurva Patel, Swaroop Revannasiddaiah, Asha Anand, Sonia Parikh, Kshitij Joshi, Malay Sarkar
Peripheral T cell lymphomas are a heterogeneous group of post-thymic, mature lymphoid malignancies, accounting for approximately 10-15% of all non-Hodgkin's lymphomas. Hepatosplenic T-cell lymphoma (HSGDTCL) is a rare entity, which is characterized by primary extra nodal disease with typical sinusoidal or sinusal infiltration of the liver and the spleen, respectively by expression of the T-cell receptor γδ chain, and by a number of other frequent clinicopathologic features, including aggressive course of disease...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29339926/using-a-chronic-hepatitis-b-registry-to-support-population-level-liver-cancer-prevention-in-sydney-australia
#6
Monica C Robotin, Ximena Masgoret, Mamta Porwal, David Goldsbury, Chee Khoo, Jacob George
Background: Approximately 1% of Australians have chronic hepatitis B (CHB), which disproportionately affects people born in hepatitis B-endemic countries. Currently, approximately half of the people affected remain undiagnosed and antiviral treatment uptake is suboptimal (~5%). This increases the likelihood of developing end-stage disease complications, particularly hepatocellular cancer (HCC), and largely accounts for the significant increases in HCC incidence and mortality in Australia over the last decades...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29339804/ephb6-and-testosterone-in-concert-regulate-epinephrine-release-by-adrenal-gland-chromaffin-cells
#7
Yujia Wang, Wei Shi, Alexandre Blanchette, Junzheng Peng, Shijie Qi, Hongyu Luo, Jonathan Ledoux, Jiangping Wu
Erythropoietin-producing human hepatocellular receptor (EPH) B6 (EPHB6) is a member of the receptor tyrosine kinase family. We previously demonstrated that EPHB6 knockout reduces catecholamine secretion in male but not female mice, and castration reverses this phenotype. We showed here that male EPHB6 knockout adrenal gland chromaffin cells presented reduced acetylcholine-triggered Ca2+ influx. Such reduction depended on the non-genomic effect of testosterone. Increased large conductance calcium-activated potassium channel current densities were recorded in adrenal gland chromaffin cells from male EPHB6 knockout mice but not from castrated knockout or female knockout mice...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335433/conformational-landscape-of-the-prkaca-dnajb1-chimeric-kinase-the-driver-for-fibrolamellar-hepatocellular-carcinoma
#8
Michael D Tomasini, Yingjie Wang, Adak Karamafrooz, Geoffrey Li, Thijs Beuming, Jiali Gao, Susan S Taylor, Gianluigi Veglia, Sanford M Simon
In fibrolamellar hepatocellular carcinoma a single genetic deletion results in the fusion of the first exon of the heat shock protein 40, DNAJB1, which encodes the J domain, with exons 2-10 of the catalytic subunit of protein kinase A, PRKACA. This produces an enzymatically active chimeric protein J-PKAcα. We used molecular dynamics simulations and NMR to analyze the conformational landscape of native and chimeric kinase, and found an ensemble of conformations. These ranged from having the J-domain tucked under the large lobe of the kinase, similar to what was reported in the crystal structure, to others where the J-domain was dislodged from the core of the kinase and swinging free in solution...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335425/sparc-expression-is-associated-with-hepatic-injury-in-rodents-and-humans-with-non-alcoholic-fatty-liver-disease
#9
Guillermo Mazzolini, Catalina Atorrasagasti, Agostina Onorato, Estanislao Peixoto, Martin Schlattjan, Jan-Peter Sowa, Svenja Sydor, Guido Gerken, Ali Canbay
Mechanisms that control progression from simple steatosis to steato-hepatitis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are unknown. SPARC, a secreted matricellular protein, is over-expressed in the liver under chronic injury. Contribution of SPARC accumulation to disease severity is largely unknown in NAFLD. We assessed the hypothesis that SPARC is increased in livers with more necrosis and inflammation and could be associated with more fibrosis. qrt-PCR, immunohistochemistry, and ELISA were employed to localize and quantify changes in SPARC in 62 morbidly obese patients with NAFLD/NASH and in a mouse model of diet-induced-NASH...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333101/variations-in-the-aurka-gene-biomarkers-for-the-development-and-progression-of-hepatocellular-carcinoma
#10
Bin Wang, Chin-Jung Hsu, Chia-Hsuan Chou, Hsiang-Lin Lee, Whei-Ling Chiang, Chen-Ming Su, Hsiao-Chi Tsai, Shun-Fa Yang, Chih-Hsin Tang
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29331759/astragaloside-iv-inhibits-cell-migration-and-viability-of-hepatocellular-carcinoma-cells-via-suppressing-long-noncoding-rna-atb
#11
Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29329986/prospects-in-non-invasive-assessment-of-liver-fibrosis-liquid-biopsy-as-the-future-gold-standard
#12
REVIEW
Joeri Lambrecht, Stefaan Verhulst, Inge Mannaerts, Hendrik Reynaert, Leo A van Grunsven
Liver fibrosis is the result of persistent liver injury, and is characterized by sustained scar formation and disruption of the normal liver architecture. The extent of fibrosis is considered as an important prognostic factor for the patient outcome, as an absence of (early) treatment can lead to the development of liver cirrhosis and hepatocellular carcinoma. Till date, the most sensitive and specific way for the diagnosis and staging of liver fibrosis remains liver biopsy, an invasive diagnostic tool, which is associated with high costs and discomfort for the patient...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29327594/liver-resection-and-surgical-strategies-for-management-of-primary-liver-cancer
#13
Sonia T Orcutt, Daniel A Anaya
Primary liver cancer-including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)-incidence is increasing and is an important source of cancer-related mortality worldwide. Management of these cancers, even when localized, is challenging due to the association with underlying liver disease and the complex anatomy of the liver. Although for ICC, surgical resection provides the only potential cure, for HCC, the risks and benefits of the multiple curative intent options must be considered to individualize treatment based upon tumor factors, baseline liver function, and the functional status of the patient...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29321958/diagnostic-value-of-strand-specific-mirna-101-3p-and-mirna-101-5p-for-hepatocellular-carcinoma-and-a-bioinformatic-analysis-of-their-possible-mechanism-of-action
#14
Xia Yang, Yu-Yan Pang, Rong-Quan He, Peng Lin, Jie-Mei Cen, Hong Yang, Jie Ma, Gang Chen
There is accumulating evidence that miRNA might serve as potential diagnostic and prognostic markers for various types of cancer. Hepatocellular carcinoma (HCC) is the most common type of malignant lesion but the significance of miRNAs in HCC remains largely unknown. The present study aimed to establish the diagnostic value of miR-101-3p/5p in HCC and then further investigate the prospective molecular mechanism via a bioinformatic analysis. First, the miR-101 expression profiles and parallel clinical parameters from 362 HCC patients and 50 adjacent non-HCC tissue samples were downloaded from The Cancer Genome Atlas (TCGA)...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29319199/histopathological-frequency-of-feline-hepatobiliary-disease-in-the-uk
#15
W A Bayton, C Westgarth, T Scase, D J Price, N H Bexfield
OBJECTIVES: To determine the histopathological frequency of feline hepatobiliary diseases in the UK and to identify breed, age and gender predispositions to developing individual diseases. METHODS: Histopathology results from 1452 feline liver biopsies were assessed. A control population of microchipped cats was used for breed comparison. Data were retrospectively categorised into hepatobiliary diseases according to World Small Animal Veterinary Association standards...
January 10, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29318558/cancer-susceptibility-models-in-protease-deficient-mice
#16
Alicia R Folgueras, Sandra Freitas-Rodríguez, Yaiza Español, Gloria Velasco
For decades, proteases have been associated with cancer progression due to the ability of some members of this large group of enzymes to degrade tumor cell surroundings, thereby facilitating cancer invasion and dissemination. However, the generation of mouse models deficient in proteases has revealed the existence of a great variety of functions among proteolytic enzymes in cancer biology, including important tumor-suppressive roles. Therefore, in this chapter, we describe methods to chemically induce different types of cancer (lung adenocarcinoma, hepatocellular carcinoma, oral and esophageal carcinoma, colorectal carcinoma, skin cancer, and fibrosarcoma) in genetically modified mouse models to efficiently evaluate the specific pro- or antitumoral function of proteases in cancer...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29317776/non-coding-rnas-in-hepatocellular-carcinoma-molecular-functions-and-pathological-implications
#17
REVIEW
Chun-Ming Wong, Felice Ho-Ching Tsang, Irene Oi-Lin Ng
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression...
January 10, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29316827/downregulation-of-mage-family-member-h1-enhances-hepatocellular-carcinoma-progression-and-serves-as-a-biomarker-for-patient-prognosis
#18
Peng-Cheng Wang, Zhi-Qiang Hu, Shao-Lai Zhou, Hao Zhan, Zheng-Jun Zhou, Chu-Bin Luo, Xiao-Wu Huang
AIM: The MAGE family member H1 (MAGEH1) belongs to melanoma-associated antigen (MAGE) superfamily. The role of MAGEH1 in hepatocellular carcinoma (HCC) is largely undefined. MATERIALS & METHODS: We used quantitative reverse transcription PCR and immunohistochemistry to detect MAGEH1 expression in HCC tissues. CCK-8 assay, wound healing migration assay and Transwell Matrigel invasion assay were used to measure HCC cell proliferation, migration and invasion ability...
January 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29314290/oncogene-rna-helicase-ddx6-promotes-the-process-of-c-myc-expression-in-gastric-cancer-cells
#19
Kohei Taniguchi, Ayako Iwatsuki, Nobuhiko Sugito, Haruka Shinohara, Yuki Kuranaga, Yuki Oshikawa, Toshihiro Tajirika, Manabu Futamura, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we examined the functions of DDX6 in clinical gastric cancer (GC) samples and GC cells. DDX6 protein expression levels of cancer samples were higher than those of the adjacent normal tissues in 25 clinical GC samples (median value: 1...
January 4, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29311391/cultural-validation-of-the-transplanted-organ-questionnaire-toq-for-the-brazilian-population
#20
Renata Medeiros, Rita Mattiello, Emmanuelle Corruble, Edgar E Sarria, Cibele Molski, Ajacio Brandão
BACKGROUND AND RATIONALE: The Transplanted Organ Questionnaire (TOQ), developed in France, is a disease-targeted instrument designed to evaluate what the transplanted organ represents to the recipient in patients who have undergone liver transplantation. The present study sought to validate a version of the TOQ for use in the Brazilian population. Translation and cross-cultural adaptation were carried out in accordance with international standard practices. Convergent validity was measured by correlations between TOQ domains and the Beck Depression Inventory (BDI), while reliability was assessed by measurement of internal consistency (Cronbach's alpha coefficient), reproducibility (intraclass correlation coefficient), sensitivity to change (effect size), and floor and ceiling effects...
December 27, 2017: Annals of Hepatology
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