keyword
https://read.qxmd.com/read/38524644/complete-reduction-surgery-of-a-huge-recurrent-adult-granulosa-cell-tumor-after-neoadjuvant-chemotherapy
#1
JOURNAL ARTICLE
Hiroha Tokui, Hideaki Yahata, Yasuhiro Okabe, Naomi Magarifuchi, Shoji Maenohara, Kazuhisa Hachisuga, Hiroshi Tomonobe, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Yoshinao Oda, Masafumi Nakamura, Kiyoko Kato
Adult granulosa cell tumors are rare, accounting for only 3-5% of all ovarian tumors. Adult granulosa cell tumors have late recurrences, for which complete resection is an effective option. We report a patient who underwent complete resection of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy. A 72-year-old woman underwent primary surgery for an adult granulosa cell tumor 19 years earlier. A huge recurrent tumor, 11 × 10 cm in size, was noted to elevate the hepatic hilum, inferior vena cava, and right renal vein...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38479177/the-double-roles-of-t-cell-mediated-immune-response-in-the-progression-of-masld
#2
REVIEW
Zigan Li, Shujun Wang, Qinchen Xu, Xin Su, Yunshan Wang, Lina Wang, Yong Zhang
Metabolic dysfunction-associated steatotic liver disease(MASLD), formerly known as non-alcoholic fatty liver disease(NAFLD), has become a major cause of chronic liver disease and a significant risk factor for hepatocellular carcinoma, which poses a huge burden on global public health and economy. MASLD includes steatotic liver disease, steatohepatitis, and cirrhosis, and the latter two cause great harm to human health and life, even complicated with liver cancer. Immunologic mechanism plays a major role in promoting its development into hepatitis and cirrhosis...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37979758/nanocomposites-of-iron-oxide-sodium-alginate-and-eugenol-induce-apoptosis-via-pi3k-akt-mtor-signaling-in-hep3-cells-and-in-vivo-hepatotoxicity-in-the-zebrafish-model
#3
JOURNAL ARTICLE
Abozer Y Elderdery, Nasser A N Alzerwi, Badr Alzahrani, Abdullah Alsrhani, Afnan Alsultan, Musaed Rayzah, Bandar Idrees, Fares Rayzah, Yaser Baksh, Ahmed M Alzahrani, Abdulrahim A Alabdulsalam, A Mohamedain, Suresh S Kumarj, Pooi Ling Mok
Hepatic cancer is among the most recurrently detected malignancies worldwide and one of the main contributors to cancer-associated mortality. With few available therapeutic choices, there is an instant necessity to explore suitable options. In this aspect, Nanotechnology has been employed to explore prospective chemotherapeutic approaches, especially for cancer treatment. Nanotechnology is concerned with the biological and physical properties of nanoparticles in the therapeutic use of drugs. In the current work, formulation, and characterization of α-Fe2O3-Sodium Alginate-Eugenol nanocomposites (FSE NCs) using several approaches like SEM and TEM, UV-visible, FTIR, and PL spectroscopy, XRD, EDAX, and DLS studies have been performed...
November 16, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37928536/case-report-successful-conversion-and-salvage-resection-of-huge-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-and-intrahepatic-metastasis-via-sequential-hepatic-arterial-infusion-chemotherapy-lenvatinib-plus-pd-1-antibody-followed-by-simultaneous
#4
Xin Luo, Rui-Zhi Chang, Dong Kuang, Mingming Yuan, Gan-Xun Li, Bixiang Zhang, Yan-Jun Wang, Wan-Guang Zhang, Ze-Yang Ding
BACKGROUND: Advanced hepatocellular carcinoma (HCC) shows poor prognosis. Combined hepatic artery infusion chemotherapy (HAIC) and lenvatinib and PD-1 antibody therapy show promising effects in treating advanced HCC, and salvage hepatectomy further promotes the overall survival in patients who were successfully converted after combined therapy. However, salvage major hepatectomy is not always amenable due to insufficient future liver remnant volume (FLV). CASE PRESENTATION: We report the case of a 59-year-old man with a huge HCC as well as multiple intrahepatic foci and portal vein tumor thrombosis at his right hemi-liver...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37787333/clear-cell-sarcoma-of-kidney-a-mimicker-of-wilms-tumor
#5
Gupta Aviral, C Mishra Sarvesh, Jaiswal Sushila, M S Ansari
The differential diagnosis for an abdominal mass in a 2-year-old child is broad and includes lesions of renal, hepatic, gastrointestinal, adrenal, and lymphatic origins. Of these, Wilms' tumor and neuroblastoma are the most common tumors, where Wilms' tumor represents about 92% of renal masses in children. Non-Wilms' renal tumors, rhabdoid tumors, and clear cell sarcoma of the kidney (CCSK) are uncommon. CCSK constitutes approximately 3% of all malignant renal tumors in childhood. In this report, we present a child presenting with a huge renal mass consistent with Wilms' tumor on computed tomography and initial biopsy...
2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/37438780/vegfr2-targeted-microbubble-based-ultrasound-molecular-imaging-improving-the-diagnostic-sensitivity-of-microinvasive-cervical-cancer
#6
JOURNAL ARTICLE
Junlin Zhong, Manting Su, Ye Jiang, Licong Huang, Ying Chen, Zhuoshan Huang, Xinling Zhang
BACKGROUND: The current diagnostic methods of microinvasive cervical cancer lesions are imaging diagnosis and pathological evaluation. Pathological evaluation is invasive and imaging approaches are of extremely low diagnostic performance. There is a paucity of effective and noninvasive imaging approaches for these extremely early cervical cancer during clinical practice. In recent years, ultrasound molecular imaging (USMI) with vascular endothelial growth factor receptor type 2 (VEGFR2) targeted microbubble (MBVEGFR2 ) has been reported to improve the early diagnosis rates of breast cancer (including ductal carcinoma in situ), pancreatic cancer and hepatic micrometastases...
July 12, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/37434955/anabolic-androgenic-anabolic-steroids-as-a-probable-risk-factor-for-hepatoblastoma-in-infants
#7
Armen Malekiantaghi, Hosein Shabani-Mirzaee, MohammadAli Ehsani, Kambiz Eftekhari
KEY CLINICAL MESSAGE: The etiology of hepatoblastoma (HB) is still unknown; several risk factors have been identified. The only risk factor for the development of HB in presented case was the child's father using anabolic androgenic steroids. It may be a risk factor for developing HB in their children. ABSTRACT: HB is the most common primary liver cancer in children. Its etiology is still unclear. The patient's father's use of androgenic anabolic steroids could be a risk factor for developing HB in his child...
July 2023: Clinical Case Reports
https://read.qxmd.com/read/37285097/robot-assisted-laparoscopy-combined-with-thoracoscopy-in-the-treatment-of-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus
#8
JOURNAL ARTICLE
Chao Song, Mingyu Chen, Ziyi Zhu, Jiang Chen, Ren'an Jin, Yewei Zhang, Linghan Gong, Zaibo Yang, Xiao Liang
BACKGROUND: Facing the 0.7-22% incidence rate of hepatocellular carcinoma (HCC) with inferior vena cava tumor thrombus (IVCTT), there are usually no obvious symptoms and signs when the tumor thrombus completely blocks the IVCTT in the early stage.1.J Gastroenterol. 29:41-46;2.Hepatogastroenterology. 41:154-157;3.Clin Cardiol. 19:211-213; Once diagnosed, it is the end-stage manifestation without unified treatment for HCC with IVCTT, bringing poor prognosis. Without active treatment, the median survival time is only 3 months...
September 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37275865/the-role-of-regulatory-t-cells-and-follicular-t-helper-cells-in-hbv-infection
#9
REVIEW
Nengqi Lin, Wei Yin, Heather Miller, Maria G Byazrova, Andrés A Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu
Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer. However, treatment for hepatitis B is limited when considering the huge base of infected people. The immune response against hepatitis B is mediated mainly by CD8+ T cells, which are key to fighting invading viruses, while regulatory T cells prevent overreaction of the immune response process. Additionally, follicular T helper cells play a key role in B-cell activation, proliferation, differentiation, and formation of germinal centers...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36807189/-a-case-of-obstructive-rectal-cancer-with-huge-liver-metastases-resected-by-the-liver-first-approach-after-chemotherapy
#10
JOURNAL ARTICLE
Kenji Kawai, Taishi Hata, Masayuki Hiraki, Ryo Ikeshima, Shinsuke Katsuyama, Go Shinke, Yoshiteru Katsura, Yoshiaki Ohmura, Keijiro Sugimura, Toru Masuzawa, Yutaka Takeda, Kohei Murata
The patient was a 68-year-old woman without history of surgery. She presented with abdominal pain and leg edema. Ultrasound scan revealed hepatic masses. Colonoscopy and abdominal CT scan revealed unresectable rectal carcinoma with massive multiple liver metastases suspected of invasion of the inferior vena cava. After a transverse colon bi-pore colostomy, 10 courses of FOLFOX plus panitumumab therapy were administered, and the liver tumor was markedly reduced in size and determined to be PR by CT. Considering the possibility of unresectability due to the liver metastases re-growth, surgery was planned with liver-first approach(LFA)...
February 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/36196724/role-of-trans-arterial-chemoembolization-tace-in-patients-with-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
A-A Meshari
OBJECTIVE: One of the most frequent types of primary liver cancer is hepatocellular carcinoma (HCC). Due to the high incidence of hepatitis B infection, HCC accounts for about 5% of all cancers. HCC is indeed one of the largest leading causes of cancer deaths in the world and the third biggest cause of cancer-related death. The purpose of our research was to see how effective TACE (Trans-Arterial Chemoembolization) therapy was in those who had hepatocellular cancer. MATERIALS AND METHODS: The Preferred Reporting Items for Systematic Reviews (PRISMA) statement was used to conduct the systemic review...
September 2022: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36037915/mitoq-demonstrates-connexin-and-p53-mediated-cancer-chemoprevention-in-n-nitrosodiethylamine-induced-hepatocarcinogenesis-rodent-model
#12
JOURNAL ARTICLE
H S Qsee, Prasad Kisan Tambe, Shounak De, Sanjay Bharati
Cancer chemoprevention is an approach that offers huge potential for preventing/retarding carcinogenesis. MitoQ is well-known and extensively studied mitochondria-targeted antioxidants for its applications in diseases linked with oxidative stress. In the present study chemopreventive potential of mitoQ was studied with a focus on the role of gap-junctions and p53 at an advanced stage of HCC. BALB/c mice model of hepatocarcinogenesis was established using N-nitrosodiethylamine as a carcinogen (200 mg/kg b. w...
August 28, 2022: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/35903496/huge-colonic-granuloma-of-schistosomiasis-mimicked-cancer-in-a-10-years-old-child-a-case-report
#13
Qasem Alyhari, Faisal Ahmed, Hani Al Shaibani, Mohammed Al Kubati, Assad Alhadi
Introduction: Schistosomiasis is a trematodes infection more prevalent in tropical and subtropical areas such as Yemen. Giant colonic polyp manifestations of intestinal bilharziasis are uncommon, difficult to differentiate from other colonic polyps, and can mimic cancer. Case Report: A 10-year-old child presented with chronic abdominal pain that started ten months ago. The patient had a family history of lymphoma in his brother. The computed tomography scan showed a sigmoid luminal mass measuring 10×3 cm with significant lumen narrowing and diffuse circumferential wall thickening of the sigmoid colon, hepatomegaly, and multiple perilesional, para-hepatic, and pulmonary lymph nodes enlargements...
2022: International Medical Case Reports Journal
https://read.qxmd.com/read/35615096/recent-trends-of-microbiota-based-microbial-metabolites-metabolism-in-liver-disease
#14
REVIEW
Raja Ganesan, Jin-Ju Jeong, Dong Joon Kim, Ki Tae Suk
The gut microbiome and microbial metabolomic influences on liver diseases and their diagnosis, prognosis, and treatment are still controversial. Research studies have provocatively claimed that the gut microbiome, metabolomics understanding, and microbial metabolite screening are key approaches to understanding liver cancer and liver diseases. An advance of logical innovations in metabolomics profiling, the metabolome inclusion, challenges, and the reproducibility of the investigations at every stage are devoted to this domain to link the common molecules across multiple liver diseases, such as fatty liver, hepatitis, and cirrhosis...
2022: Frontiers in Medicine
https://read.qxmd.com/read/34904416/aqueous-extracts-from-tenebrio-molitor-larval-and-pupal-stages-inhibit-early-hepatocarcinogenesis-in-vivo
#15
JOURNAL ARTICLE
Armando Zepeda-Bastida, Juan Ocampo-López, Brisa Rodope Alarcón-Sánchez, Osiris Germán Idelfonso-García, Sandra Rosas-Madrigal, Diana Ivette Aparicio-Bautista, Julio Isael Pérez-Carreón, Saúl Villa-Treviño, Jaime Arellanes-Robledo
Hepatocellular carcinoma (HCC), which is the most frequent primary liver malignancy, is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide, with its incidence expected to continue rising. One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective. The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins, such as in hepatitis virus infection, alcohol consumption, aflatoxin from contaminated foods, metabolic factors, and exposure to chemical carcinogens from tobacco smoke (Forner et al...
December 15, 2021: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/34858889/drug-eluting-bead-transarterial-chemoembolization-combined-with-folfox-based-hepatic-arterial-infusion-chemotherapy-for-large-or-huge-hepatocellular-carcinoma
#16
JOURNAL ARTICLE
Jingjun Huang, Wensou Huang, Meixiao Zhan, Yongjian Guo, Licong Liang, Mingyue Cai, Liteng Lin, Mingji He, Hui Lian, Ligong Lu, Kangshun Zhu
Purpose: To evaluate the safety and efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with oxaliplatin plus fluorouracil and leucovorin (FOLFOX)-based hepatic arterial infusion chemotherapy (D-TACE-HAIC) for unresectable large (5.1-10 cm) or huge (>10 cm) hepatocellular carcinoma (HCC). Methods: This retrospective study evaluated consecutive patients with unresectable large or huge HCC who underwent D-TACE-HAIC (D-TACE-HAIC group) or DEB-TACE (DEB-TACE group) from January 2017 to December 2020...
2021: Journal of Hepatocellular Carcinoma
https://read.qxmd.com/read/34253511/extremely-high-alpha-fetoprotein-producing-adrenal-hepatoid-adenocarcinoma
#17
JOURNAL ARTICLE
Tawasapon Thambamroong, Naiyarat Prasongsook, Kantang Satayasoontorn, Siriwimon Saichaemchan
Hepatoid adenocarcinoma (HAC) is a rare tumour that produces an alpha-fetoprotein (AFP) mimicking hepatocellular carcinoma (HCC). Adrenal HAC is exceedingly rare. Here we report extremely high AFP-producing adrenal HAC, the first case in Thailand. A 47-year-old man presented with left flank pain and weight loss for 2 months. A palpably huge left flank mass was observed on physical examination. CT revealed a 7 cm enhanced mass involving the left adrenal gland and multiple contrast-enhanced hypodense masses in both liver lobes...
July 12, 2021: BMJ Case Reports
https://read.qxmd.com/read/34228433/lipopeptides-for-vaccine-development
#18
JOURNAL ARTICLE
Ian W Hamley
The development of lipopeptides (lipidated peptides) for vaccines is discussed, including their role as antigens and/or adjuvants. Distinct classes of lipopeptide architectures are covered including simple linear and ligated constructs and lipid core peptides. The design, synthesis, and immunological responses of the important class of glycerol-based Toll-like receptor agonist lipopeptides such as Pam3 CSK4 , which contains three palmitoyl chains and a CSK4 hexapeptide sequence, and many derivatives of this model immunogenic compound are also reviewed...
July 6, 2021: Bioconjugate Chemistry
https://read.qxmd.com/read/34193808/elevation-of-ca-19-9-in-mirizzi-syndrome-in-the-absence-of-malignancy-a-case-report
#19
JOURNAL ARTICLE
Leena H Moshref, Rasha Abdulaziz Mandili, Murouj Almaghrabi, Rahaf Abdulrashid Abdulwahab, Rawan A Alosaimy, Jameel Miro
BACKGROUND Mirizzi syndrome (MS) is relatively a rare condition; incidence rates may increment with age. It is characterized as an obstruction of the common hepatic duct (CHD) auxiliary to outward compression of an infected stone in the cystic duct. Carbohydrate antigen (CA) 19-9 is a tumor marker that is usually related to upper-gastrointestinal malignancies. However, a few case reports have shown high levels of CA19-9 in the absence of malignancy. In this case, we report a case of a patient with MS, elevated CA19-9, and radiological findings suggesting gallbladder cancer, which shows the challenges of diagnosis and therapeutic procedures...
July 1, 2021: American Journal of Case Reports
https://read.qxmd.com/read/34082094/near-infrared-light-controllable-mxene-hydrogel-for-tunable-on-demand-release-of-therapeutic-proteins
#20
JOURNAL ARTICLE
Song Wang, Zhenhua Zhang, Shaohua Wei, Fang He, Zhu Li, Hong-Hui Wang, Yan Huang, Zhou Nie
Precise delivery of therapeutic protein drugs that specifically modulate desired cellular responses is critical in clinical practice. However, the spatiotemporal regulation of protein drugs release to manipulate the target cell population in vivo remains a huge challenge. Herein, we have rationally developed an injectable and Near-infrared (NIR) light-responsive MXene-hydrogel composed of Ti3 C2 , agarose, and protein that enables flexibly and precisely control the release profile of protein drugs to modulate cellular behaviors with high spatiotemporal precision remotely...
August 2021: Acta Biomaterialia
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