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huge hepatic cancer

Andrea Szentesi, Emese Tóth, Emese Bálint, Júlia Fanczal, Tamara Madácsy, Dorottya Laczkó, Imre Ignáth, Anita Balázs, Petra Pallagi, József Maléth, Zoltán Rakonczay, Balázs Kui, Dóra Illés, Katalin Márta, Ágnes Blaskó, Alexandra Demcsák, Andrea Párniczky, Gabriella Pár, Szilárd Gódi, Dóra Mosztbacher, Ákos Szücs, Adrienn Halász, Ferenc Izbéki, Nelli Farkas, Péter Hegyi
OBJECTIVE: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas. METHODS: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period. Overall, 1,554,325 articles were analyzed...
2016: PloS One
Xin Long, Jian Wang, Jian-Ping Zhao, Hui-Fang Liang, Peng Zhu, Qi Cheng, Qian Chen, Yan-Hui Wu, Zhan-Guo Zhang, Bi-Xiang Zhang, Xiao-Ping Chen
The function of the spleen in tumor development has been investigated for years. The relationship of the spleen with hepatocellular carcinoma (HCC), a huge health burden worldwide, however, remains unknown. The present study aimed to examine the effect of splenectomy on the development of HCC and the possible mechanism. Mouse hepatic carcinoma lines H22 and Hepa1-6 as well as BALB/c and C57 mice were used to establish orthotopic and metastatic mouse models of liver cancer. Mice were divided into four groups, including control group, splenectomy control group (S group), tumor group (T group) and tumor plus splenectomy group (T+S group)...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Atsuyuki Ikeda, Yumiko Yasuhara, Daizen Hirata, Mari Teramura, Takeharu Nakamura, Yoko Oiwa, Osamu Araki, Hidemasa Azechi, Ryuta Nishitai, Hiroyuki Kokuryu
We report a case of resected hepatocellular carcinomas (HCCs) after drug-eluting bead transarterial chemoembolization (DEB-TACE). A 67-year-old man with alcoholic liver disease was diagnosed with HCCs. Serological markers for hepatitis B and C viruses were negative. Among tumor markers, alpha-fetoprotein was 2.7ng/mL, and protein induced by vitamin K absence II was 868mAU/mL. Two HCCs were detected using dynamic computed tomography: one was 9cm in diameter in S8 and the other was 2cm in diameter in S4. We performed DEB-TACE using HepaSphere(®) and epirubicin...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Satoru Kikuchi, Masahiko Nishizaki, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara
BACKGROUND: Bochdalek hernia (BH) is generally congenital, presenting with respiratory distress. However, this pathology is rarely detected in adults. Some adult cases of BH present with symptoms attributed to the hernia, but incidental detection of BH is increasing among asymptomatic adults due to advances in imaging modalities. This report presents the management of incidental BH patients detected in the preoperative period of gastric cancer. CASE PRESENTATION: An asymptomatic 76-year-old woman was diagnosed with advanced gastric cancer during follow-up after radiotherapy for uterine cervical cancer...
June 1, 2016: BMC Surgery
L Benhaim, C Honoré, D Goéré, J-B Delhorme, D Elias
BACKGROUND: Complete cytoreductive surgery (CCRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is the best-known treatment for pseudomyxoma peritonei (PMP). In 30% of the cases, PMP realize a widespread involvement of the peritoneal cavity. In these extreme situations, we developed, devoted strategies to optimize the feasibility and safety of CCRS. This study describes the surgical resections required for CCRS and the consequent approaches that we propose to achieve CCRS. MATERIALS AND METHODS: We defined "huge PMP" by a peritoneal cancer index (PCI) ≥ 28...
April 2016: European Journal of Surgical Oncology
Tivadar Bara, Simona Gurzu, Ioan Jung, Mircea Muresan, Janos Szederjesi, Tivadar Bara
Hemangiomas are the most common benign tumors of the liver, considered giant when they exceed 50-100 mm in diameter. In the present report, we present a case of a 5.2-kg hemangioma of the right hepatic lobe, with hemangiomatous foci in the left lobe, which was incidentally diagnosed in a 53-year-old obese female hospitalized for uterine bleeding. The computed tomographic scan and physical examination revealed a giant abdominal tumor and hepatic hemangioma of the right hepatic lobe was suspected. Right hepatectomy and total hysterectomy with bilateral ovariectomy was performed...
February 2016: Anticancer Research
Yasunori Hasuike, Ichirou Higuchi, Akira Ishikawa, Yosuke Akiyama, Takahiko Tanigawa, Atsuya Okada, Taisuke Toyomasu
We report a patient who experienced a weight loss, general fatigue, and appetite loss and had huge hepatic metastases of colon cancer after right lobectomy for hepatic stone. After 2 courses of treatment with high-dose hepatic arterial infusion of 5-FU (HDHAI; 5-FU 6 g/week), the appetite loss decreased, and low anterior resection was performed. Unfortunately, the other symptoms continued, and she received 5 additional courses of HDHAI during about 6 months. Finally, all of the symptoms disappeared, and she could receive systemic chemotherapy and HAI...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kennosuke Ohashi, Takeshi Hayashi, Masaya Sakamoto, Hiroyuki Iuchi, Hirofumi Suzuki, Takanori Ebisawa, Katsuyoshi Tojo, Hironobu Sasano, Kazunori Utsunomiya
BACKGROUND: Aldosterone-producing adrenocortical carcinoma is a rare malignancy, which is usually diagnosed by histopathological examination of the excised tumor. In inoperable cases, aldosterone-producing ACC diagnosed by immunohistochemical staining of the metastatic tumor for Cytochrome P450 (CYP) 11β has not previously been reported and even in that case staining for adrenocortical-specific adrenal 4 binding protein/steroidogenic factor1 (Ad4BP/SF1) and steroidogenic enzymes has not been reported...
2016: BMC Endocrine Disorders
Eun Ha Seo, Chung-Sung Lee, Kun Na
Nanoparticles with "smart" stimuli-responsive materials and multiple therapeutic strategies in a single delivery platform have emerged for highly efficient cancer therapy. Here, photomediated reactive oxygen species (ROS)-generable nanoparticles are designed that can trigger drug release and endo/lysosomal escape upon attenuated single light irradiation, simultaneously, for synergistic chemo-photodynamic ablation. In this study, the self-ROS-generable nanoparticles (SRNs) are prepared from the polymer based on polysaccharide, chlorin e6 as ROS generator and lipoic acid as ROS scavenger covalently conjugated pullulan with anticancer drug (doxorubicin, DOX) through self-assembly, and can disassemble via the ROS-mediated reduction of lipoyl group in response to low level exogenous single light switch...
December 30, 2015: Advanced Healthcare Materials
Sumiya Ishigami, Takaaki Arigami, Keishi Okubo, Ken Sasaki, Hiroshi Kurahara, Yoshikazu Uenosono, Hiroshi Okumura, Tetsuhiro Owaki, Yuko Kijima, Shinichi Ueno, Shoji Natsugoe
Gastric cancers with portal tumor thrombosis (GCPTs) are a rare entity, often concomitant with hematogenous metastases, and chemotherapy is mainly used to treat them. However, the outcome of GCPT is reported to be dismal. We experienced a case of GCPT with splenic metastases. A 53-year-old man was admitted for anorexia. Upper gastrointestinal scope revealed type 3 gastric cancer of the stomach. Abdominal computed tomography showed a huge tumor thrombus in the splenic vein extending to the hepatic hilus and multiple metastases to the spleen...
June 2012: Clinical Journal of Gastroenterology
R J Kuo, W C Cheng, W C Lien, T J Yang
Taiwan is an area where chronic hepatitis is endemic. Liver cancer is so common that it has been ranked first among cancer mortality rates since the early 1980s in Taiwan. Besides, liver cirrhosis and chronic liver diseases are the sixth or seventh in the causes of death. Therefore, as shown by the active research on hepatitis, it is not only a health threat, but also a huge medical cost for the government. The estimated total number of hepatitis B carriers in the general population aged more than 20 years old is 3,067,307...
October 2015: Computer Methods and Programs in Biomedicine
Mei-Hwei Chang, Ding-Shinn Chen
Hepatitis B virus (HBV) causes life-threatening liver disease. It is transmitted through a horizontal route or a mother-to-infant route, and the latter is the major route in endemic areas. Prevention of HBV infection by immunization is the best way to eliminate HBV-related diseases. The HBV vaccine is the first human vaccine using a viral antigen from infected persons, which is safe and effective. Either passive immunization by hepatitis B immunoglobulin (HBIG) or active immunization by HBV vaccine is effective, and a combination of both yields the best efficacy in preventing HBV infection...
March 2, 2015: Cold Spring Harbor Perspectives in Medicine
Tongchun Xue, Fan Le, Rongxin Chen, Xiaoying Xie, Lan Zhang, Ningling Ge, Yi Chen, Yanhong Wang, Boheng Zhang, Shenglong Ye, Zhenggang Ren
Patients with huge hepatocellular carcinoma >10 cm in diameter represent a special subgroup for treatment. To date, there are few data and little consensus on treatment strategies for huge hepatocellular carcinoma. In this study, we summarized the effects and safety of transarterial chemoembolization for huge hepatocellular carcinoma. A retrospective study was performed based on a large cohort of patients (n = 511) with huge hepatocellular carcinoma who underwent serial transarterial chemoembolization between January 2008 to December 2011 and were followed up until March 2013...
March 2015: Medical Oncology
Shigetomi Nakao, Bunzo Nakata, Masashige Tendo, Kenji Kuroda, Takeshi Hori, Mayumi Inaba, Kosei Hirakawa, Tetsuro Ishikawa
BACKGROUND: Patient with α-Fetoprotein (AFP)-producing gastric cancer usually has a short survival time due to frequent hepatic and lymph node metastases. Gastric cancer with portal vein tumor thrombus (PVTT) is rare and has an extremely poor prognosis. CASE PRESENTATION: A 63-year-old man was found to have a huge Type 3 gastric cancer with a PVTT and a highly elevated serum AFP level. Chemotherapy with S-1 plus cisplatin was given to this patient with unresectable gastric cancer for 4 months...
January 16, 2015: BMC Surgery
Chengyuan Peng, Franck Chiappini, Slávka Kaščáková, Mélanie Danulot, Christophe Sandt, Didier Samuel, Paul Dumas, Catherine Guettier, François Le Naour
Non-alcoholic fatty liver disease (NAFLD) is a frequent lesion associated with obesity, diabetes and the metabolic syndrome. The hallmark feature of fatty liver disease is steatosis, which is the intra-cellular accumulation of lipids resulting in the formation of vesicles in hepatocytes. Steatosis is a precursor of steatohepatitis, a condition that may progress to hepatic fibrosis, cirrhosis and primary liver cancer. We addressed the potential of Fourier transform-infrared (FTIR) microspectroscopy for grading steatosis on frozen tissue sections...
February 21, 2015: Analyst
Hyun Goo Woo, Soon Sun Kim, Hyunwoo Cho, So Mee Kwon, Hyo Jung Cho, Seun Joo Ahn, Eun Sung Park, Ju-Seog Lee, Sung Won Cho, Jae Youn Cheong
Recent advances in sequencing technology have allowed us to profile genome-wide mutations of various cancer types, revealing huge heterogeneity of cancer genome variations. However, its heterogeneous landscape of somatic mutations according to liver cancer progression is not fully understood. Here, we profiled the mutations and gene expressions of early and advanced hepatocellular carcinoma (HCC) related with Hepatitis B-viral infection. Integrative analysis was performed with whole-exome sequencing and gene expression profiles of the 12 cases of early and advanced HCCs and paired non-tumoral adjacent liver tissues...
2014: PloS One
Zhi-Ming Zhang, Yu-Mei Zhang, Sheng Gao, Wei-Ping Yuan, Yin-Nong Zhao, Bang-De Xiang, Fei-Xiang Wu, Guo-Bin Wu, Jian-Yong Liu
OBJECTIVE: To explore the most appropriate treatment for patients with hepatocellular cancer (HCC)>10 cm by using the Barcelona Clinic Liver Cancer (BCLC) classification. MATERIALS AND METHODS: A total of 124 HCC patients undergoing surgery were selected. Disease-free survival (DFS), overall survival (OS) and prognostic factors were respectively assessed. RESULTS: This study showed that the cumulative 1-, 3-, 5-year survival rates were 79...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
A S Luca, Carmen Dorobăţ, Ramona Gabriela Ursu, Mihaela Cătălina Luca, A Vâţă, Luminiţa Smaranda Iancu
UNLABELLED: HBV virus infection is an important public health problem because of its huge transmission potential, and severe evolution to cirrhosis or liver cancer. AIM: Analysis of the epidemiological and laboratory features of chronic hepatitis B virus infection. MATERIAL AND METHODS: The patients with chronic hepatitis B admitted to the "Sf. Parascheva" University Hospital for Infectious Diseases in the interval: January 1st, 2010 - December 31st were analyzed...
April 2014: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
B Gaborit, I Abdesselam, F Kober, A Jacquier, O Ronsin, O Emungania, N Lesavre, M-C Alessi, J C Martin, M Bernard, A Dutour
OBJECTIVES: Recent literature suggests that ectopic fat deposition in the pancreas may contribute to endocrine and exocrine organ dysfunction, such as type 2 diabetes (T2D), pancreatitis or pancreatic cancer. The aim of this study was to determine factors associated with pancreatic triglyceride content (PTGC), and to investigate the impact of bariatric surgery on ectopic fat pads, pancreatic fat (PTGC) and hepatic fat (HTGC). SUBJECTS: In all, 45 subjects (13 lean, 13 obese nondiabetics and 19 T2D, matched for age and gender) underwent 1H-magnetic resonance spectroscopy, computed tomography of the visceral abdominal fat, metabolic and lipidomic analysis, including insulin-resistance homeostasis model assessment (HOMA-IR), insulin-secretion homeostasis model assessment (HOMA-B) and plasma fatty-acid composition...
March 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Yun-Wen Zheng, Tomonori Tsuchida, Taiki Shimao, Bin Li, Takanori Takebe, Ran-Ran Zhang, Yu Sakurai, Yasuharu Ueno, Keisuke Sekine, Naoto Ishibashi, Makiko Imajima, Takuji Tanaka, Hideki Taniguchi
Hepatocellular carcinoma (HCC) is a malignant tumor associated with a generally poor prognosis and a high rate of recurrence. HCC usually develops in the context of chronic liver diseases, and long-lasting premalignant conditions precede cancer development. A promising therapeutic approach is to eliminate precancerous cells, which are considered as the precursors of cancer stem cells, to prevent further malignant transformation. In this study, we identified a subpopulation of precancerous cells in a rat liver carcinogenesis model, which were enriched in CD133(+)CD44(+)CD45(-)HIS49(-) cells that formed part of the hepatic oval cells fraction...
September 15, 2014: Stem Cells and Development
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