Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan
BACKGROUND: The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients. An increasing body of literature suggests that circular RNAs (circRNAs) are important regulators for HCC. However, few circRNAs involved in the Warburg effect of HCC have hitherto been investigated. Herein, we aimed to explore the contribution of circFOXK2 to glucose metabolism reprogramming in HCC. METHODS: In the present study, different primers were designed to identify 14 circRNAs originating from the FOXK2 gene, and their differential expression between HCC and adjacent liver tissues was screened...
March 15, 2023: Journal of Experimental & Clinical Cancer Research: CR