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Ted R Mikuls, Clay Walker, Fang Qiu, Fang Yu, Geoffrey M Thiele, Barnett Alfant, Eric C Li, Lisa Y Zhao, Gary P Wang, Susmita Datta, Jeffrey B Payne
Objectives: To profile and compare the subgingival microbiome of RA patients with OA controls. Methods: RA (n = 260) and OA (n = 296) patients underwent full-mouth examination and subgingival samples were collected. Bacterial DNA was profiled using 16 S rRNA Illumina sequencing. Following data filtering and normalization, hierarchical clustering analysis was used to group samples. Multivariable regression was used to examine associations of patient factors with membership in the two largest clusters...
March 19, 2018: Rheumatology
Isabela Moda, Hilton Marcos Alves Ricz, Lilian Neto Aguiar-Ricz, Roberto Oliveira Dantas
BACKGROUND: Dysphagia is described as a complaint in 32% of patients with laryngitis. OBJECTIVE: The objective of this investigation was to evaluate oral and pharyngeal transit of patients with laryngitis, with the hypothesis that alteration in oral-pharyngeal bolus transit may be involved with dysphagia. METHODS: Videofluoroscopic evaluation of the swallowing of liquid, paste and solid boluses was performed in 21 patients with laryngitis, 10 of them with dysphagia, and 21 normal volunteers of the same age and sex...
January 2018: Arquivos de Gastroenterologia
Jovana de Moura Milanesi, Luana Cristina Berwig, Mariana Marquezan, Luiz Henrique Schuch, Anaelena Bragança de Moraes, Ana Maria Toniolo da Silva, Eliane Castilhos Rodrigues Corrêa
PURPOSE: : This study was conducted to identify variables associated with mouth breathing diagnosis in children, based on multidisciplinary domains. METHODS: 119 children, six to 12 years old, underwent anamnesis, speech therapy (orofacial structures and stomatognathic functions), otorhinolaryngologic (OTRL) with clinical and endoscopic examinations, dental (occlusion) and physiotherapy (body posture and nasal patency) assessments. Nasal patency was evaluated using Peak Nasal Inspiratory Flow (PNIF) and the Nasal Obstruction Symptom Evaluation (NOSE) scale...
March 19, 2018: CoDAS
W C Chen, Y T Chang, S F Chen, W C Lin, Y Y Su, S D Luo
BACKGROUND: Dysregulation of the autonomic system can affect sinonasal physiological function and may exacerbate the symptom burden associated with rhinosinusitis. However, the association between autonomic dysfunction and chronic rhinosinusitis (CRS) has seldom been studied. Here, we investigated the relationship between autonomic dysfunction and CRS. METHODS: Patients with CRS who failed medical treatment were prospectively enrolled. All patients underwent pre-operative examinations and completed questionnaires, including the reflux symptom index (RSI) and the Sino-nasal Outcome Test-22 (SNOT-22)...
March 21, 2018: Rhinology
Andrew D Engell, Na Yeon Kim, Gregory McCarthy
Perception of faces has been shown to engage a domain-specific set of brain regions, including the occipital face area (OFA) and the fusiform face area (FFA). It is commonly held that the OFA is responsible for the detection of faces in the environment, whereas the FFA is responsible for processing the identity of the face. However, an alternative model posits that the FFA is responsible for face detection and subsequently recruits the OFA to analyze the face parts in the service of identification. An essential prediction of the former model is that the OFA is not sensitive to the arrangement of internal face parts...
March 21, 2018: Journal of Cognitive Neuroscience
Pierre H M Pechon, Rhys Pullin, Mark J Eaton, Stephan A Jones, Sam Evans
During uncemented hip arthroplasty the femoral prosthesis can be fitted too tightly into the femoral canal, causing a hoop-stress fracture of the proximal femur. The research undertaken evaluated Acoustic Emission (AE) technology as a potential method of detecting a fracture forming in this manner, in an attempt to assess whether this technology may be used as a means of early warning of impending fracture during surgery. Deer femora were prepared in a manner similar to surgery and uncemented hip arthroplasty broaches were inserted until fracture occurred...
March 21, 2018: Journal of Medical Engineering & Technology
Mei-Jun Deng, Chun-Yan Liu, Yu Xie, Jie-Bin Zhu, Zhen-Hua Xu
OBJECTIVE: To summarize the regularity of application of Lianquan (CV 23) in clinical practice in Chinese ancient times through analysis of ancient traditional Chinese medical (TCM) literature. METHODS: A total of 60 books involving CV 23 from the 1 156 ancient TCM books listed in the fifth edition of Encyclopedia of Traditional Chinese Medicine were collected by using CV 23 as the main keyword and "Sheben" "Benchi", and "Jieben" (the other names of CV 23 in TCM)as the supplementary keywords and analyzed systematically...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Vito Crincoli, Mariasevera Di Comite, Mariateresa Guerrieri, Rossana Patricia Rotolo, Luisa Limongelli, Angela Tempesta, Florenzo Iannone, Angela Rinaldi, Giovanni Lapadula, Gianfranco Favia
AIMS : Sjӧgren Syndrome is a disorder involving oral tissues, with xerostomia, dysgeusia, dysphagia, tooth decay, gingivitis, angular cheilitis and glossitis. Temporomandibular disorders are a generic term referred to clinical conditions involving the jaw muscles and temporomandibular joint. The aim of this study was to investigate the prevalence of oral manifestations and temporomandibular disorders (TMD) in Sjӧgren Syndrome (SS) patients compared with healthy people. METHODS : The study group included 72 SS patients (2 men, 70 women) diagnosed according to the American-European Consensus Group (AECG) Criteria...
2018: International Journal of Medical Sciences
Jeonghyun Kim, Hyung-Mi Cho, Guebuem Kim
Fluorescent dissolved organic matter (FDOM) is important for marine organisms and the global carbon cycle contributing to the optical properties of surface seawater and organic carbon budgets. Rivers are known to be the main source of FDOM in coastal oceans and marginal seas. In this study, however, we show that the contribution of FDOM produced from organic sediments of the northwestern Pacific continental shelf is similar to that from the Changjiang River. FDOM showed relatively higher concentrations at stations off the Changjiang River mouth and in the central Yellow Sea...
March 20, 2018: Scientific Reports
Jingjing Li, Hao Pan, Xiangshi Wang, Qirong Zhu, Yanling Ge, Jiehao Cai, Yuefang Li, Aimei Xia, Jiayu Hu, Mei Zeng
Hand, foot, and mouth disease (HFMD) is mainly epidemic in China and Southeast Asian countries. A novel enterovirus 71 vaccine has been available in China for preventing severe HFMD since 2016. Knowledge of the dynamic epidemiology of HFMD in different regions is necessary for appropriate intervention strategies. This study focused on the citywide surveillance data on the epidemiology and etiology of HFMD in Shanghai during 2014-2016. In these 3 years, the total numbers of reported HFMD cases were 65,018, 39,702, and 57,548, respectively; the numbers of severe cases (case-severity ratios) were 248 (0...
March 21, 2018: Emerging Microbes & Infections
Manuel Bratos, Jumping M Bergin, Jeffrey E Rubenstein, John A Sorensen
STATEMENT OF PROBLEM: Conventional impression techniques to obtain a definitive cast for a complete-arch implant-supported prosthesis are technique-sensitive and time-consuming. Direct optical recording with a camera could offer an alternative to conventional impression making. PURPOSE: The purpose of this in vitro study was to test a novel intraoral image capture protocol to obtain 3-dimensional (3D) implant spatial measurement data under simulated oral conditions of vertical opening and lip retraction...
March 17, 2018: Journal of Prosthetic Dentistry
Tobias M R Houlton, Caroline Wilkinson
Shrunken heads are a mummification phenomenon unique to South America. Ceremonial tsantsa are ritually reduced heads from enemy victims of the Shuar, Achuar, Awajún (Aguaruna), Wampís (Huambisa), and Candoshi-Shapra cultures. Commercial shrunken heads are comparatively modern and fraudulently produced for the curio-market, often using stolen bodies from hospital mortuaries and graves. To achieve shrinkage and desiccation, heads undergo skinning, simmering (in water) and drying. Considering the intensive treatments applied, this research aims to identify how the facial structure can alter and impact identification using post-mortem depiction...
March 6, 2018: Forensic Science International
Scott A Dee, Fernando V Bauermann, Megan C Niederwerder, Aaron Singrey, Travis Clement, Marcelo de Lima, Craig Long, Gilbert Patterson, Maureen A Sheahan, Ana M M Stoian, Vlad Petrovan, Cassandra K Jones, Jon De Jong, Ju Ji, Gordon D Spronk, Luke Minion, Jane Christopher-Hennings, Jeff J Zimmerman, Raymond R R Rowland, Eric Nelson, Paul Sundberg, Diego G Diel
The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV)...
2018: PloS One
Magdalena Ewa Król
We investigated the effect of auditory noise added to speech on patterns of looking at faces in 40 toddlers. We hypothesised that noise would increase the difficulty of processing speech, making children allocate more attention to the mouth of the speaker to gain visual speech cues from mouth movements. We also hypothesised that this shift would cause a decrease in fixation time to the eyes, potentially decreasing the ability to monitor gaze. We found that adding noise increased the number of fixations to the mouth area, at the price of a decreased number of fixations to the eyes...
2018: PloS One
Katherine E Queck, Angela Chapman, Leslie J Herzog, Tamara Shell-Martin, Anthony Burgess-Cassler, George David McClure
Periodontal disease in dogs is highly prevalent but can only be accurately diagnosed by performing an anesthetized oral examination with periodontal probing and dental radiography. In this study, 114 dogs had a visual awake examination of the oral cavity and were administered an oral-fluid thiol-detection test prior to undergoing a a full-mouth anesthetized oral examination and digital dental radiographs. The results show the visual awake examination underestimated the presence and severity of active periodontal disease...
March 20, 2018: Journal of the American Animal Hospital Association
Marco Esposito, Daniele Cardaropoli, Luca Gobbato, Fabio Scutellà, Andrea Fabianelli, Saverio Mascellani, Gianluca Delli Ficorelli, Fabio Mazzocco, Luca Sbricoli, Anna Trullenque-Eriksson
PURPOSE: To evaluate whether there are aesthetic and clinical benefits to using a newly designed abutment (Curvomax), over a conventional control abutment (GingiHue). MATERIALS AND METHODS: A total of 49 patients, who required at least two implants, had two sites randomised according to a split-mouth design to receive one abutment of each type at seven different centres. The time of loading (immediate, early or delayed) and of prosthesis (provisional crowns of fixed prosthesis) was decided by the clinicians, but they had to restore both implants in a similar way...
2018: European Journal of Oral Implantology
Janet Baack Kukreja, Qiuling Shi, Courtney M Chang, Mohamed A Seif, Brandon M Sterling, Ting-Yu Chen, Kelly M Creel, Ashish M Kamat, Colin P Dinney, Neema Navai, Jay B Shah, Xin Shelley Wang
BACKGROUND: Bladder cancer is a disease of the elderly that is associated with high morbidity in those treated with radical cystectomy. In this observational study of patients with bladder cancer undergoing radical cystectomy, we analyzed and compared patient-reported outcomes from those treated with Enhanced Recovery After Surgery (ERAS) methods versus those who received traditional perioperative care. METHODS: We enrolled patients who underwent radical cystectomy at a high-volume tertiary care referral center from November 2013 to December 2016, when the ERAS concept was being introduced into postoperative care at our institution...
March 1, 2018: Surgical Innovation
Shih Han Lin, Tom M Y Lin
The choice of medical services affects an individual's treatment and health. However, few studies have focused on medical electronic word-of-mouth (eWOM), which has the greatest impact on such choices. This study was performed to explore the need for and general public's attitude toward medical eWOM and provide a reference for government, media, and medical practitioners. In this study, 84% of the respondents had experience using online evaluation platforms to search for eWOM, and those who were satisfied with the online evaluation platforms substantially outnumbered those who were dissatisfied...
January 1, 2018: Journal of International Medical Research
Tim L Wigal, Jeffrey H Newcorn, Nelson Handal, Sharon B Wigal, Ioulietta Mulligan, Virginia Schmith, Eric Konofal
BACKGROUND: Mazindol is under investigation for the treatment of attention-deficit/hyperactivity disorder (ADHD) because of its alertness-enhancing properties. A novel controlled-release (CR) formulation of mazindol was developed to allow once-daily dosing. OBJECTIVE: The aim of this study was to evaluate the efficacy of mazindol CR in adults with ADHD. DESIGN: We conducted a randomized, double-blind, placebo-controlled 6-week trial. METHODS: Subjects diagnosed with ADHD using the Mini-International Neuropsychiatric Structured Interview (MINI) and with an ADHD Rating Scale, Diagnostic and Statistical Manual of Mental Disorders 5th Edition (ADHD-RS-DSM5) score ≥ 28 were randomized to receive placebo or 1-3 mg/day of mazindol for 6 weeks...
March 19, 2018: CNS Drugs
Hsiao-Ling Chen, Tun-Chieh Chen, Hsiu-Mei Chang, Yung-Shun Juan, Wei-Hsuan Huang, Hung-Fang Pan, Yong-Chieh Chang, Chiou-Mei Wu, Ya-Ling Wang, Hsiang Ying Lee
PURPOSE: Mirabegron, a β3-adrenoceptor agonist, was approved for overactive bladder (OAB), but worsened hypertension was a potential risk based on its mechanism of action. Besides, head to head comparisons were limited between mirabegron and antimuscarinic agents, the prior first-line pharmacotherapy of OAB. In this regard, we performed a systematic review and meta-analysis to compare their efficacy as well as safety, especially in blood pressure changes. MATERIALS AND METHODS: Literature search was conducted in PubMed, Medline and seven randomized clinical trial (RCT) register databases of WHO, EU, USA, Taiwan, China, Japan and Cochrane...
March 19, 2018: World Journal of Urology
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