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https://www.readbyqxmd.com/read/29792911/prolonged-drug-release-properties-for-orodispersible-films-by-combining-hot-melt-extrusion-and-solvent-casting-methods
#1
Isabell Speer, Maren Preis, Jörg Breitkreutz
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the ease of administration without water and suitability for patients with swallowing problems. However, this promising dosage form has been limited to immediate release formulations so far. The aim of this study was to develop a thin film produced by solvent casting, which is rapidly disintegrating when placed in the mouth, but which provides prolonged drug release characteristics by incorporating drug-loaded matrix particles (MPs)...
May 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29792910/perception-of-children-with-visible-untreated-and-treated-caries
#2
Claudia Tschammler, David Zimmermann, Sarah Batschkus, Annette Wiegand, Kristian Folta-Schoofs
OBJECTIVES: This study aimed to analyse if children with untreated or treated caries (restorations/missing teeth) are perceived differently compared to children with healthy teeth and to explore possible differences in the perception by laypersons and dental experts. METHODS: Eye movements of female experts (n = 20) and laypersons (n = 18) were recorded by eye-tracking while paired images (neutral expression/teeth not visible; emotional expression/smiling, teeth visible) of children with healthy teeth, with visible untreated or treated caries (restorations/missing teeth as a consequence of caries treatment), each n = 13, were presented...
May 21, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29792172/oral-health-and-orofacial-pain-in-people-with-dementia-admitted-to-acute-hospital-wards-observational-cohort-study
#3
Liza J M van de Rijt, Roxane A F Weijenberg, Alexandra R Feast, Victoria Vickerstaff, Frank Lobbezoo, Elizabeth L Sampson
BACKGROUND: Orofacial pain in people with dementia is difficult to detect, and often under-treated. Our aim was to investigate the prevalence of orofacial pain in people with dementia in acute hospitals in the UK. Secondary aims were to examine oral health status and explore associations between orofacial pain and oral health factors. METHODS: This cross-sectional observational study was carried out in two UK hospitals. Using the Orofacial Pain Scale in Non-Verbal Individuals (OPS-NVI) to identify orofacial pain, 101 participants with dementia, admitted to acute medical wards, were observed for at least 3 min during rest and chewing...
May 23, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29791486/involvement-of-the-renin-angiotensin-system-in-the-progression-of-severe-hand-foot-and-mouth-disease
#4
Chao Zhang, Shuaiyin Chen, Guangyuan Zhou, Yuefei Jin, Rongguang Zhang, Haiyan Yang, Yuanlin Xi, Jingchao Ren, Guangcai Duan
BACKGROUND: Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD...
2018: PloS One
https://www.readbyqxmd.com/read/29789506/design-and-efficacy-of-nanogels-formulations-for-intranasal-administration
#5
REVIEW
Blessing A Aderibigbe, Tobeka Naki
Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease...
May 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29787978/persistence-of-bacterial-pathogens-antibiotic-resistance-genes-and-enterococci-in-tidal-creek-tributaries
#6
Chance E Jones, Anthony Maddox, Dorset Hurley, Andrei L Barkovskii
Intertidal creeks form the primary hydrologic link between estuaries and land-based activities on barrier islands. Fecal indicators Enterococcus spp. (Entero1), pathogens Shigella spp. (ipaH), Salmonella spp. (invA), E. coli of EHEC/EPEC groups (eaeA), E. coli of EAEC, EIEC, and UPEC groups (set1B), E. coli of STEC group (stx1); and tetracycline resistance genes (tet(B), tet(C), tet(D), tet(E), tet(K), tet(Q), tet(W), and tet(X); TRG) were detected in the headwater of Oakdale Creek (Sapelo Island, GA) receiving runoffs from Hog Hammock village...
May 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29786957/statistical-approaches-to-adjusting-weights-for-dependent-arms-in-network-meta-analysis
#7
Yu-Xuan Su, Yu-Kang Tu
Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only one treatment. However, some trials use within person designs such as split-body, split-mouth and cross-over designs, where each patient may receive more than one treatment. Data from treatment arms within these trials are no longer independent, so the correlations between dependent arms need to be accounted for within the statistical analyses...
May 22, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29786702/color-stability-psychosocial-impact-and-effect-on-self-perception-of-esthetics-of-tooth-whitening-using-low-concentration-6-hydrogen-peroxide
#8
Pablo Angel, Cristian Bersezio, Juan Estay, Andrea Werner, Hector Retamal, Constanza Araya, Javier Martin, Eduardo Fernández
OBJECTIVE: The aim of this study was to assess the bleaching efficacy and impact on psychosocial and esthetics self-perception of a low-concentration (6%) hydrogen peroxide (H2O2) gel compared with a conventional (37.5%) H2O2 gel when used as an in-office treatment. METHOD AND MATERIALS: In total, 35 participants received two sessions of three 12-minute applications of treatment with 37.5% H2O2 on one side of the mouth and 6% H2O2 on the other. Color changes were measured objectively using total variation in color (ΔE) and subjectively using Vita Classical scale (ΔSGU)...
May 17, 2018: Quintessence International
https://www.readbyqxmd.com/read/29786519/effect-of-vaccination-on-cattle-subclinically-infected-with-foot-and-mouth-disease-virus-in-cameroon
#9
Miranda R Bertram, Amy Delgado, Steven J Pauszek, George R Smoliga, Barbara Brito, Carolina Stenfeldt, Ethan J Hartwig, Simon Dickmu Jumbo, Mamoudou Abdoulmoumini, Amba Abona Oliva Marie, Robert Salhine, Luis L Rodriguez, Rebecca Garabed, Jonathan Arzt
Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786501/strategies-to-increase-filipino-american-participation-in-cardiovascular-health-promotion-a-systematic-review
#10
Jermy-Leigh B Domingo, Gretchenjan Gavero, Kathryn L Braun
INTRODUCTION: Cultural tailoring of interventions can be effective in reducing health disparities by attracting underserved populations to health promotion programs and improving their outcomes. The purpose of this systematic review was to assess what is known about increasing access to and participation in cardiovascular disease (CVD) prevention and control programs among Filipino Americans. METHODS: PubMed MEDLINE, CINAHL, and Sociologic Abstracts were searched for peer-reviewed studies and dissertations conducted in the United States from 2004 through 2016...
May 17, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29786046/effect-of-double-balloon-enteroscopy-on-diagnosis-and-treatment-of-small-bowel-diseases
#11
Li Tang, Liu-Ye Huang, Jun Cui, Cheng-Rong Wu
Background: The diagnosis and treatment of small-bowel diseases is clinically difficult. The purpose of this study was to evaluate the diagnostic and therapeutic value of double-balloon enteroscopy in small-bowel diseases. Methods: The history and outcomes of 2806 patients who underwent double-balloon enteroscopy from July 2004 to April 2017 were reviewed, which included 562 patients with obscure digestive tract bleeding, 457 patients with obscure diarrhea, 930 patients with obscure abdominal pain, 795 patients with obscure weight loss, and 62 patients with obscure intestinal obstruction...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785893/evaluating-vaccination-strategies-to-control-foot-and-mouth-disease-a-country-comparison-study
#12
T G Rawdon, M G Garner, R L Sanson, M A Stevenson, C Cook, C Birch, S E Roche, K A Patyk, K N Forde-Folle, C Dubé, T Smylie, Z D Yu
Vaccination is increasingly being recognised as a potential tool to supplement 'stamping out' for controlling foot-and-mouth disease (FMD) outbreaks in non-endemic countries. Infectious disease simulation models provide the opportunity to determine how vaccination might be used in the face of an FMD outbreak. Previously, consistent relative benefits of specific vaccination strategies across different FMD simulation modelling platforms have been demonstrated, using a UK FMD outbreak scenario. We extended this work to assess the relative effectiveness of selected vaccination strategies in five countries: Australia, New Zealand, the USA, the UK and Canada...
May 22, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29785679/drooling-in-parkinson-s-disease-evidence-of-a-role-for-divided-attention
#13
Hannah Reynolds, Nick Miller, Richard Walker
Drooling is a frequently reported symptom in Parkinson's Disease (PD) with significant psychosocial impact and negative health consequences including silent aspiration of saliva with the associated risk of respiratory infections. It is suggested that in PD drooling is associated with inefficient oropharyngeal swallowing which reduces the effective clearance of saliva rather than hyper-salivation. This is compounded by unintended mouth opening and flexed posture increasing anterior loss of saliva. It is reported to occur most frequently during cognitively distracting concurrent tasks suggesting an impact from divided attention in a dual-task situation...
May 21, 2018: Dysphagia
https://www.readbyqxmd.com/read/29785345/greenland-shark-somniosus-microcephalus-feeding-behavior-on-static-fishing-gear-effect-of-smart-selective-magnetic-and-repellent-treated-hook-deterrent-technology-and-factors-influencing-entanglement-in-bottom-longlines
#14
Scott M Grant, Rennie Sullivan, Kevin J Hedges
The Greenland Shark ( Somniosus microcephalus ) is the most common bycatch in the Greenland halibut ( Reinhardtius hippoglossoides ) bottom longline fishery in Cumberland Sound, Canada. Historically, this inshore fishery has been prosecuted through the ice during winter but winter storms and unpredictable landfast ice conditions since the mid-1990s have led to interest in developing a summer fishery during the ice-free season. However, bycatch of Greenland shark was found to increase substantially with 570 sharks captured during an experimental Greenland halibut summer fishery (i...
2018: PeerJ
https://www.readbyqxmd.com/read/29785258/intra-articular-biomaterials-assisted-delivery-to-treat-temporomandibular-joint-disorders
#15
Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim
The temporomandibular joint disorder, also known as myofascial pain syndrome, is considered one of the prevalent chronic pain diseases caused by muscle inflammation and cartilage degradation in head and neck, and thus influences even biopsychosocial conditions in a lifetime. There are several current treatment methodologies relieving inflammation and preventing degradation of the joint complex. One of the promising non-surgical treatment methods is an intra-articular injection of drugs such as corticosteroids, analgesics, and anti-depressants...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29785159/assessment-of-the-quality-of-life-and-performance-status-in-patients-with-oral-submucous-fibrosis-in-central-india
#16
Revant H Chole, Ranjitkumar Patil
Background and aims: Measuring quality of life in patients with oral submucous fibrosis is of utmost importance in assessing treatment outcomes. This study examined the impact of oral submucous fibrosis and its treatment on the quality of life and performance status of persons with oral submucous fibrosis. Methods: Quality of life was measured in patients with oral submucous fibrosis using the European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire (EORTC QLQ-C35); performance status was measured by Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), at four points in time: baseline, one month, two months and three months after start of treatment...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29785145/linking-product-design-to-consumer-behavior-the-moderating-role-of-consumption-experience
#17
Naeem Gul Gilal, Jing Zhang, Faheem Gul Gilal
Background: Previous investigations of product design broadly link aesthetic, functional, and symbolic designs to sales growth, high turnover, and market share. However, the effect of product design dimensions on consumer willingness-to-buy (WTB) and word-of-mouth (WOM) is virtually ignored by consumer researchers. Similarly, whether the consumption experience can differentiate the effect of the three product design dimensions on WTB and WOM is completely unknown. Using categorization theory as a lens, our study aims to explore the effect of product design dimensions on consumer WTB and WOM directly and indirectly through the moderation of the consumption experience...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29784306/enzymatic-hydrolysis-of-flaxseed-linum-usitatissimum-l-protein-and-sensory-characterization-of-maillard-reaction-products
#18
Chao-Kun Wei, Kiran Thakur, Dun-Hua Liu, Jian-Guo Zhang, Zhao-Jun Wei
We aimed to simplify the enzymolysis process for flaxseed protein hydrolysates production as Maillard reaction products (MRPs) to generate different flavor characteristics. More than 50% activity of immobilized enzymes (Alcalase and Flavourzyme) was retained after repeated use. Subsequently, after five weeks, the activities of the immobilized enzymes were also observed to be higher after storage at 4 °C. The optimum conditions for production of flaxseed protein hydrolysates using sequential enzymatic hydrolysis were as follow: 3,000 U/g of Alcalase at 60 °C and pH 8...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29784008/socio-demographic-factors-dental-status-and-health-related-behaviors-associated-with-geriatric-oral-health-related-quality-of-life-in-southwestern-china
#19
Rui Shao, Tao Hu, Yi-Si Zhong, Xue Li, Yi-Bo Gao, Yi-Fan Wang, Wei Yin
BACKGROUND: The aging of Chinese society has increased interest in improving the health-related quality of life (HRQoL) of the elderly, including their oral health-related quality of life (OHRQoL). This study aims to evaluate the OHRQoL of elders living in Sichuan Province (China) and to explore the explanatory factors of their OHRQoL. METHODS: A cross-sectional study conducted in 2016 in the Sichuan Province analyzed data from 744 elders, aged 65 to 74 years (mean age 69...
May 21, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29783814/-epidemiology-and-management-development-of-hand-foot-and-mouth-disease-in-chinese-mainland-a-ten-year-review
#20
S Y Qian, X W Li
No abstract text is available yet for this article.
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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