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https://www.readbyqxmd.com/read/29341485/development-of-a-chemiluminescence-immunoassay-using-recombinant-non-structural-epitope-based-proteins-to-accurately-differentiate-foot-and-mouth-disease-virus-infected-and-vaccinated-bovines
#1
Z-Z Liu, F-R Zhao, S-D Gao, J-J Shao, Y-G Zhang, H-Y Chang
The contamination of inactivated vaccine with non-structural proteins (NSPs) leads to a high false-positive rate, which is a substantial barrier to accurately differentiate foot-and-mouth disease virus (FMDV)-infected animals from vaccinated animals. To address this problem, a new chemiluminescence immunoassay (CLIA) method was developed to detect antibodies targeting the two recombinant epitope-based proteins located in 3A and 3B. The 3Aepitp-3Bepitp CLIA exhibited a diagnostic sensitivity of 94.0% and a diagnostic specificity of 97...
January 16, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29341067/vitamin-e-for-antipsychotic-induced-tardive-dyskinesia
#2
REVIEW
Karla Soares-Weiser, Nicola Maayan, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. Vitamin E has been proposed as a treatment to prevent or decrease TD. OBJECTIVES: The primary objective was to determine the clinical effects of vitamin E in people with schizophrenia or other chronic mental illness who had developed antipsychotic-induced TD...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29340500/respiratory-evaluation-through-volumetric-capnography-among-grade-iii-obese-and-eutrophic-individuals-a-comparative-study
#3
Débora Aparecida Oliveira Modena, Marcos Mello Moreira, Ilma Aparecida Paschoal, Mônica Corso Pereira, Luiz Cláudio Martins, Everton Cazzo, Elinton Adami Chaim
BACKGROUND: Excess trunk body fat in obese individuals influences respiratory physiological function. The aims of this study were to compare volumetric capnography findings (VCap) between severely obese patients and normal-weight subjects and to assess whether there is any association between neck circumference (NC), waist-hip ratio (WHR) and VCap among grade III obese individuals. DESIGN AND SETTING: Analytical observational case-matched cross-sectional study, University of Campinas...
January 15, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29339332/human-perturbation-increases-the-fluxes-of-dissolved-molybdenum-from-land-to-ocean-the-case-of-the-jiulong-river-in-china
#4
Deli Wang, Shuimiao Lu, Nengwang Chen, Minhan Dai, Céline Guéguen
Rivers contribute a substantial amount of trace metals including molybdenum (Mo) into the oceans. The driving forces controlling the riverine fluxes of dissolved metals still remain not fully understood. Our study then investigated the spatial variations of dissolved metals including molybdenum in a typically human perturbed river, the Jiulong River (JR), China. The aim of the study is to elucidate the relevance of anthropogenic perturbation on the fluxes of dissolved metals such as molybdenum from land to ocean...
January 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29338309/oral-microbiota-reduce-wound-healing-capacity-of-epithelial-monolayers-irrespective-of-the-presence-of-5-fluorouracil
#5
Eline Vanlancker, Barbara Vanhoecke, Tom Sieprath, Janie Bourgeois, Annelore Beterams, Barbara De Moerloose, Winnok H De Vos, Tom Van de Wiele
Oral mucositis is still one of the most painful side effects of chemotherapeutic treatment and a mounting body of evidence suggests a key role for the oral microbiome in mucositis development. However, the underlying mechanisms remain elusive. In this work, we have investigated the interactions between the host, the microbiome, and chemotherapeutic treatments in more detail. The effect of 5-fluorouracil, commonly inducing mucositis, was assessed on a co-culture model that consists of an epithelial cell layer and a biofilm derived from oral microbiota from different types of samples (saliva, buccal swabs and tongue swabs) and donors (healthy individuals and patients suffering from mucositis)...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29338080/phase-1-trial-evaluating-cisplatin-gemcitabine-and-veliparib-in-2-patient-cohorts-germline-brca-mutation-carriers-and-wild-type-brca-pancreatic-ductal-adenocarcinoma
#6
Eileen M O'Reilly, Jonathan W Lee, Maeve A Lowery, Marinela Capanu, Zsofia K Stadler, Malcolm J Moore, Neesha Dhani, Hedy L Kindler, Hayley Estrella, Hannah Maynard, Talia Golan, Amiel Segal, Erin E Salo-Mullen, Kenneth H Yu, Andrew S Epstein, Michal Segal, Robin Brenner, Richard K Do, Alice P Chen, Laura H Tang, David P Kelsen
BACKGROUND: A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine the safety, dose-limiting toxicities (DLTs), maximum tolerated dose, and recommended phase 2 dose (RP2D) of veliparib combined with cisplatin and gemcitabine and to assess the antitumor efficacy (Response Evaluation Criteria in Solid Tumors, version 1...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337392/oral-health-related-concerns-behavior-and-communication-with-health-care-providers-of-patients-with-breast-cancer-impact-of-different-treatments
#7
L Susan Taichman, Catherine H Van Poznak, Marita R Inglehart
AIM: The objectives are to compare responses of breast cancer (BCa) treatment groups (chemotherapy, tamoxifen, and aromatase inhibitors (AIs) to each other and a control regarding (a) subjective oral health, (b) oral health-related behaviors, (c) oral health-related concerns, and (d) communication with health care providers. METHODS: Survey data were collected from 140 postmenopausal BCa patients and 41 healthy postmenopausal control respondents. RESULTS: BCa patients reported on average more frequent mouth sores/mucositis (5-point scale with 1 = never: 1...
January 16, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29336286/oral-allergy-syndrome
#8
Nuray Bayar Muluk, Cemal Cingi
OBJECTIVES: To review oral allergy syndrome (OAS). METHODS: We searched several medical literature data bases with the following key words: "oral allergy syndrome," "OAS," "pollen-food allergy syndrome," "PFAS," "allergy," "diagnosis," "treatment." RESULTS: Oral allergy syndrome (OAS), also called "pollen-food allergy syndrome," is a type of food allergy brought about by flavors, nuts, raw fruit, and vegetables. The most well-known symptoms are mouth and throat itching, which starts rapidly after a food is placed in the mouth, and that, as a rule, continues for just a couple of minutes after the food has been swallowed...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29335398/massive-post-obstructive-diuresis
#9
Stewart W Shankel
BACKGROUND The purpose of presenting this case is to demonstrate the degree to which the kidney is capable of selectively excreting a massive load of sodium and water when challenged with both of these, without altering the plasma levels of other ions. CASE REPORT An 8-year-old boy was admitted in severe renal failure. Workup demonstrated a high grade obstruction of a single kidney. Following dialysis, the patient underwent surgery to correct the obstruction and he developed post-obstructive diuresis. Within one week he was receiving 34 liters of essentially 1/2 Na by IV and by mouth and was excreting 70% of his filtered load of water and 50% of his filtered load of sodium...
January 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29335165/dioxins-furans-and-dioxin-like-pcbs-in-sediment-samples-and-suspended-particulate-matter-from-the-scheldt-estuary-and-the-north-sea-coast-comparison-of-calux-concentration-levels-in-historical-and-recent-samples
#10
T Vandermarken, Y Gao, W Baeyens, M S Denison, K Croes
BACKGROUND: The Scheldt estuary is historically a highly polluted river system. While several studies have focused on contamination with metals, pesticides, Polycyclic Aromatic Hydrocarbons (PAHs) and marker PolyChlorinated Biphenyls (PCBs), no data are available concerning past contamination by dioxin-like compounds. OBJECTIVES: The objective of this study is to determine spatial and time trends of PolyChlorinated Dibenzo-p-Dioxins and DibenzoFurans (PCDD/Fs) and dioxin-like PCBs (dl-PCBs) in sediment samples and Suspended Particulate Matter (SPM) from the Scheldt River basin and the North Sea Coast...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29335053/facial-nerve-paresis-case-report-of-blunt-facial-nerve-injury
#11
John M Kim, Michael J Ryhn, Thomas R Stark
Facial nerve paresis is an uncommon but concerning condition in the pediatric population. The function and anatomy of the facial nerve is complex, and injuries to this structure may be associated with devastating physiological and psychological implications for the affected child and family. The purpose of this paper was to report a case involving a six-year-old Caucasian female who suffered a blunt traumatic injury to the orofacial region resulting in partial paralysis of the seventh cranial nerve. Following the injury, the child was unable to fully elevate the corner of her mouth...
November 1, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29335051/effectiveness-of-a-preventive-recall-strategy-for-children-after-dental-rehabilitation-with-general-anesthesia
#12
Elizabeth J Berry, Tegwyn H Brickhouse, Amanda K Kerns, Katherine A Nordeen, Al M Best
PURPOSE: To test a more frequent preventive recall strategy following full-mouth dental rehabilitation (FMDR) in children with early childhood caries (ECC). METHODS: Patients were randomized into two groups: controls, who were scheduled to return at six-month intervals (6-MR); and the intervention group, who were scheduled to return at three-month intervals (3-MR and 6-MR). At baseline and at each recall, a caries risk assessment (CRA) and dental exam were completed...
November 1, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29334948/molecular-identification-and-investigations-of-contagious-ecthyma-orf-virus-in-small-ruminants-north-west-ethiopia
#13
Mebrahtu Tedla, Nega Berhan, Wassie Molla, Wudu Temesgen, Sefinew Alemu
BACKGROUND: Orf virus, the prototype of parapoxvirus, is the main causative agent of contagious ecthyma. Little is known about the status of the disease in Ethiopia and this study was aimed at determining its status using PCR as a confirmatory tool. METHODS: a total of 400 randomly selected sheep and goat was screened for the identification of the virus using amplification of B2L gene and transfection of mammalian cells (VERO cells). RESULTS: Out of 400 animals screened for infection of the virus, 48 animals were found positive to PCR and revealed an overall incidence of 12%...
January 15, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29334821/development-and-validation-of-a-facial-expression-database-based-on-the-dimensional-and-categorical-model-of-emotions
#14
Tomomi Fujimura, Hiroyuki Umemura
The present study describes the development and validation of a facial expression database comprising five different horizontal face angles in dynamic and static presentations. The database includes twelve expression types portrayed by eight Japanese models. This database was inspired by the dimensional and categorical model of emotions: surprise, fear, sadness, anger with open mouth, anger with closed mouth, disgust with open mouth, disgust with closed mouth, excitement, happiness, relaxation, sleepiness, and neutral (static only)...
January 15, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29334582/carbohydrate-mouth-rinsing-does-not-prevent-the-decline-in-maximal-strength-following-fatiguing-exercise
#15
Christopher D Black, Daniel J Schubert, Marcin K Szczyglowski, Joshua D Wren
Carbohydrate (CHO) rinsing has been shown to attenuate the decline of maximal voluntary contractions (MVC) following fatiguing exercise-perhaps via a central mechanism. This study sought to determine the effect of a CHO rinse on MVC, voluntary activation, and contractile properties following fatiguing exercise. Thirteen adults participated in a double-blind, cross-over study. MVC of the dominant knee extensors was assessed and voluntary activation (%VA) was determined using twitch-interpolation. Participants then held 50% of MVC until volitional fatigue followed by a 20s rinse with a solution of 8% maltodextrin (CHO) or placebo (PLA)...
January 12, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29334435/comparative-antiplaque-effect-of-two-antimicrobial-dentifrices-laboratory-and-clinical-evaluations
#16
Lynn R Friesen, C R Goyal, Jimmy G Qaqish, Tao He, Rachelle Eusebio, Marianne Zsiska, Teresa Farmer, Eva Schneiderman
OBJECTIVES: To compare the effect of a stannous fluoride dentifrice versus a triclosan-containing dentifrice on the reduction of plaque using in vitro and clinical models. METHODS: Both investigations evaluated a novel 0.454% stabilized stannous fluoride dentifrice (Crest® Pro-Health™ smooth formula) versus a sodium fluoride/triclosan positive control dentifrice (Colgate® Total®). The in vitro evaluation utilized the Plaque Glycolysis and Regrowth Model (PGRM), wherein the metabolic effects (acid production/glycolysis inhibition) of the dentifrices were assessed on plaque biofilms grown on glass rods after three days growth and a single dentifrice treatment...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29333582/outpatient-erbium-yag-2940%C3%A2-nm-laser-treatment-for-snoring-a-prospective-study-on-40-patients
#17
Isabelle Fini Storchi, Steven Parker, Francesca Bovis, Stefano Benedicenti, Andrea Amaroli
Snoring is a sleep phenomenon due to the partial upper airway obstruction during sleep which causes vibration of the tissues of the rhino-oro-hypopharynx and less frequently the larynx. This study evaluated the use and effectiveness of the erbium:YAG 2940-nm laser as an adjunctive in providing treatment for patients suffering from chronic snoring-related sleep disorders. A prospective study of 40 consecutive patients with snoring and sleep disorders was performed, assessing data before and after three Er:YAG laser treatment sessions...
January 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29332554/evaluating-the-dose-dependent-mechanism-of-action-of-trazodone-by-estimation-of-occupancies-for-different-brain-neurotransmitter-targets
#18
Luca Settimo, David Taylor
Trazodone is a drug that was introduced in the clinic almost 40 years ago. It is licensed to treat depression, but it is also commonly used off-label to treat insomnia. A recent study shows that it could be promising in preventing neurodegeneration in mice, and clinical trials to assess its possible beneficial effects on dementia and Alzheimer's disease are expected to start soon in humans. In this study, we describe the dose-dependent pharmacology of trazodone by carrying out pharmacokinetic simulations aiming to predict the brain concentrations of trazodone for different drug-dosing regimens and calculating occupancy for 28 different targets for which published trazodone-binding data are available...
January 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29332208/localised-aggressive-periodontitis-in-a-3-year-old-boy
#19
E Mass, F Hershkovitz, U Zilberman
BACKGROUND: Localised aggressive periodontitis (LAgP), characterised by rapid attachment and bone loss, which may occur in children and adolescents, without clinical evidence of systemic disease. CASE REPORT: Three-year-old boy was referred with excessive mobility of 83 and exfoliation of 73. Clinical examination revealed acceptable oral hygiene. Blood tests were performed to evaluate PMNs activity and the parents were advised to apply 0.2% chlorhexidine twice a day...
January 13, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29332113/changes-in-the-temporomandibular-joint-disc-and-temporal-and-masseter-muscles-secondary-to-bruxism-in-turkish-patients
#20
Hasan Garip, Sukran Tufekcioglu, Emre Kaya
To analyze the relationships between temporalis and masseter muscle hypertrophy and temporomandibular joint (TMJ) disc displacement in patients with severe bruxism using magnetic resonance imaging (MRI). Methods: This retrospective study included 100 patients with severe bruxism, referred to the Department of Oral and Maxillofacial Surgery, University of Marmara and Istanbul Medipol University, Istanbul, Turkey, between January 2015 and December 2016. Patients underwent TMJ MRI with a 1.5-T system in open and closed mouth positions...
January 2018: Saudi Medical Journal
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