Brigida E Annicchiarico, Concetta Santonocito, Massimo Siciliano, Margherita Scapaticci, Donatella Guarino, Carmine Di Stasi, Maria E Riccioni, Enrico Di Stasio, Ettore Capoluongo, Antonio Gasbarrini
BACKGROUND: In liver cirrhosis, the renin-angiotensin-aldosterone system is involved in the pathogenesis of portal hypertension. Its effector, angiotensin II, is generated by angiotensin-converting enzyme (ACE). Serum ACE levels are affected by I/D polymorphism of its gene, with alleles I and D being associated, respectively, with lesser and greater activity of the enzyme. In cirrhotic patients carrying the ACE I allele, an increased risk for gastro-oesophageal varices was observed. AIM: The aim of our study was to evaluate whether ACE I/D polymorphism influenced portal pressure...
August 28, 2018: Digestive and Liver Disease