keyword
https://read.qxmd.com/read/38528641/low-expression-of-mir-182-caused-by-dna-hypermethylation-accelerates-acute-lymphocyte-leukemia-development-by-targeting-pbx3-and-bcl2-mir-182-promoter-methylation-is-a-predictive-marker-for-hypomethylation-agents%C3%A2-%C3%A2-bcl2-inhibitor-venetoclax
#21
JOURNAL ARTICLE
Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou, Shenmeng Gao
BACKGROUND: miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells have high miR-182 promoter methylation has not been determined. METHODS: To assess the methylation status of the miR-182 promoter, methylation and unmethylation-specific PCR analysis, bisulfite-sequencing analysis, and MethylTarget™ assays were performed to measure the frequency of methylation at the miR-182 promoter...
March 26, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38527944/major-low-energy-trauma-results-in-non-specific-immunoglobulin-generation-without-evidence-for-specific-autoantibody-production-a-prospective-cohort-study
#22
JOURNAL ARTICLE
Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova
Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control...
March 25, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38527908/status-of-b-lymphocyte-subsets-and-their-homing-markers-in-patients-with-post-kala-azar-dermal-leishmaniasis
#23
JOURNAL ARTICLE
Shilpa Sengupta, Deep Goswami, Bidhan Chakraborty, Surya Jyati Chaudhuri, Manab K Ghosh, Mitali Chatterjee
In visceral leishmaniasis, the Type II helper T cell predominance results in B cell modulation and enhancement of anti-leishmanial IgG. However, information regarding its dermal sequel, post-kala-azar dermal leishmaniasis (PKDL), remains limited. Accordingly, this study aimed to elucidate the B cell-mediated antibody-dependent/independent immune profiles of PKDL patients. In the peripheral blood of PKDL patients, immunophenotyping of B cell subsets was performed by flow cytometry and by immunohistochemistry at lesional sites...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38527692/hexavalent-chromium-exposure-activates-the-non-canonical-nuclear-factor-kappa-b-pathway-to-promote-immune-checkpoint-protein-programmed-death-ligand-1-expression-and-lung-carcinogenesis
#24
JOURNAL ARTICLE
Po-Shun Wang, Zulong Liu, Osama Sweef, Abdullah Farhan Saeed, Thomas Kluz, Max Costa, Kenneth R Shroyer, Kazuya Kondo, Zhishan Wang, Chengfeng Yang
Lung cancer is the leading cause of cancer-related death worldwide; however, the mechanism of lung carcinogenesis has not been clearly defined. Chronic exposure to hexavalent chromium [Cr(VI)], a common environmental and occupational pollutant, causes lung cancer, representing an important lung cancer etiology factor. The mechanism of how chronic Cr(VI) exposure causes lung cancer remains largely unknown. By using cell culture and mouse models and bioinformatics analyses of human lung cancer gene expression profiles, this study investigated the mechanism of Cr(VI)-induced lung carcinogenesis...
March 23, 2024: Cancer Letters
https://read.qxmd.com/read/38527267/investigational-approaches-for-treatment-of-melanoma-patients-progressing-after-standard-of-care
#25
JOURNAL ARTICLE
Kylie A Fletcher, Douglas B Johnson
The advent of effective immunotherapy, specifically cytotoxic T-lymphocyte associated protein 4 and programmed cell death 1 inhibitors, as well as targeted therapy including BRAF/MEK inhibitors, has dramatically changed the prognosis for metastatic melanoma patients. Up to 50% of patients may experience long-term survival currently. Despite these advances in melanoma treatment, many patients still progress and die of their disease. As such, there are many studies aimed at providing new treatment options for this population...
March 2024: Cancer Journal
https://read.qxmd.com/read/38527265/tumor-infiltrating-lymphocyte-and-other-cell-therapies-for-metastatic-melanoma
#26
JOURNAL ARTICLE
Christy Los, Sebastian Klobuch, John B A G Haanen
Major progress in prolonging survival of patients with advanced melanoma has been made in the past decade because of the development and approval of immune checkpoint inhibitor and targeted therapies. However, for nonresponding or relapsing patients, their prognosis is still dismal. Based on clinical trial data, treatment with adoptive cell therapies holds great promise. In patients with metastatic melanoma progressing on or nonresponsive to single-agent anti-programmed cell death 1, infusion of tumor-infiltrating lymphocytes can produce responses in up to half of patients, with durable complete responses in up to 20%...
March 2024: Cancer Journal
https://read.qxmd.com/read/38526792/discovery-of-live-cell-selective-fluorescent-probes-and-elucidation-of-their-mechanisms-case-study-of-b-cell-selective-probe-cdgb
#27
JOURNAL ARTICLE
Haw-Young Kwon, Young-Tae Chang, Nam-Young Kang
The development of small-molecule fluorescent probes for specific immune cell identification offers an economical alternative to expensive antibodies. Moreover, it enables the identification of live target cells and provides insights into the distinct properties of cells, leveraging their specific staining mechanisms. This chapter presents a comprehensive elucidation of the methodology employed for screening fluorescent compounds using flow cytometry measurements. A novel analytical approach is proposed to distinguish a fluorescent compound with a specific carbon length for B lymphocytes, involving an assessment of the staining index and the predominant ratio of immune cells...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38526216/the-aryl-hydrocarbon-receptor-differentially-modulates-the-expression-profile-of-antibody-isotypes-in-a-human-b-cell-line
#28
JOURNAL ARTICLE
Mili S Bhakta-Yadav, Kaulini Burra, Nasser Alhamdan, Clayton P Allex-Buckner, Courtney E W Sulentic
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant and high affinity ligand for the aryl hydrocarbon receptor (AhR). In animal models, AhR activation by TCDD generally inhibits antibody secretion. However, it is less clear if this translates to human antibody production. Using a human Burkitt lymphoma B-cell line (CL-01) that can be stimulated to secrete Ig and undergo class switch recombination to other Ig isotypes, the current study evaluated the effects of AhR activation or antagonism on the human Ig isotypic expression profile with CD40L+IL-4 stimulation...
March 25, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38525813/abcs-begin-with-zeb2
#29
JOURNAL ARTICLE
James J Knox, Michael P Cancro
Age-associated B cells (ABCs) are a stable subset of memory B lymphocytes that develop during microbial infections and in autoimmune diseases. Despite growing appreciation of their phenotypic and functional characteristics, the transcriptional networks involved in ABC fate commitment and maintenance have remained elusive. In their recent publication, Dai et al. tackle this problem, leveraging both mouse models and human diseases to reveal zinc finger E-box-binding homeobox 2 (ZEB2) as a key transcriptional regulator of ABC lineage specification...
March 25, 2024: Immunology and Cell Biology
https://read.qxmd.com/read/38525442/impacts-of-cryopreservation-on-phenotype-and-functionality-of-mononuclear-cells-in-peripheral-blood-and-ascites
#30
JOURNAL ARTICLE
Jie Zhang, Zhongnan Yin, Zhaoyuan Liang, Yang Bai, Ting Zhang, Jianling Yang, Xianlong Li, Lixiang Xue
BACKGROUND: Mononuclear cells in peripheral blood and ascites are important clinical resources commonly used in translational and basic research. However, the impact of different cryopreservation durations and extra freeze-thaw cycles on the number and function of mononuclear cells is unknown. METHODS: Peripheral blood samples ( n = 21) and ascites samples ( n = 8) were collected from healthy volunteers and ovarian cancer patients. Mononuclear cells were isolated, frozen, and thawed at 6 and 12 months...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38525129/pathological-changes-in-various-organs-in-hla-b-57-01-transgenic-mice-with-abacavir-induced-skin-eruption
#31
JOURNAL ARTICLE
Akira Kazaoka, Kazuyoshi Kumagai, Junya Matsushita, Tetsuo Aida, Saki Kuwahara, Shigeki Aoki, Kousei Ito
UNLABELLED: Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a few patients resulting in death due to multiorgan failure. Understanding the sequential changes in various organs in patients with cutaneous eruption following drug administration will help understand disease onset and progression, aiding the development of prevention strategies and interventions. Therefore, we aimed to understand the effects of abacavir (ABC) on various organs in patients with ABC-induced eruptions by evaluating its effects in a mouse model...
April 2024: Toxicological Research
https://read.qxmd.com/read/38525109/b-cell-pathway-dual-inhibition-for-systemic-lupus-erythematosus-a-prospective-single-arm-cohort-study-of-telitacicept
#32
JOURNAL ARTICLE
Lanlan Ji, Yan Geng, Xiaohui Zhang, Xuerong Deng, Zhibo Song, Meng Tan, Ying Tan, Chenxue Qu, Zhuoli Zhang
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with B-cell hyperactivity. Telitacicept is a transmembrane activator, calcium modulator, and cyclophilin ligand interactor-Fc fusion protein, which can neutralize both B-cell lymphocyte stimulator and a proliferation-inducing ligand. Patients with active SLE who received telitacicept were prospectively followed at month 1, 3, 6, 9, and 12 after telitacicept initiation. Thirty-seven participants were involved and followed for 6...
April 2024: MedComm
https://read.qxmd.com/read/38524775/cold-tumour-phenotype-explained-through-whole-genome-sequencing-in-clinical-nasopharyngeal-cancer-a-preliminary-study
#33
JOURNAL ARTICLE
Handoko, Marlinda Adham, Lisnawati Rachmadi, Heri Wibowo, Soehartati A Gondhowiardjo
INTRODUCTION: Nasopharyngeal cancer (NPC) is a complex cancer due to its unique genomic features and association with the Epstein-Barr virus (EBV). Despite therapeutic advancements, NPC prognosis remains poor, necessitating a deeper understanding of its genomics. Here, we present a comprehensive whole genome sequencing (WGS) view of NPC genomics and its correlation with the phenotype. METHODS: This study involved WGS of a clinical NPC biopsy specimen. Sequencing was carried out using a long read sequencer from Oxford Nanopore...
2024: ImmunoTargets and Therapy
https://read.qxmd.com/read/38524502/causal-role-of-immune-cells-in-obstructive-sleep-apnea-hypopnea-syndrome-mendelian-randomization-study
#34
JOURNAL ARTICLE
Huang-Hong Zhao, Zhen Ma, Dong-Sheng Guan
BACKGROUND: Despite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies (GWAS) and genotyping techniques using high-density genetic markers ( e.g. , SNP or CNVs). But this tactic hasn't yet been applied to OSAHS...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523528/patterns-of-b-cell-lymphocyte-expression-changes-in-pre-and-post-malignant-prostate-tissue-are-associated-with-prostate-cancer-progression
#35
JOURNAL ARTICLE
Sudha M Sadasivan, Ian M Loveless, Yalei Chen, Nilesh S Gupta, Ryan Sanii, Kevin R Bobbitt, Dhananjay A Chitale, Sean R Williamson, Andrew G Rundle, Benjamin A Rybicki
BACKROUND: Inflammation characterized by the presence of T and B cells is often observed in prostate cancer, but it is unclear how T- and B-cell levels change during carcinogenesis and whether such changes influence disease progression. METHODS: The study used a retrospective sample of 73 prostate cancer cases (45 whites and 28 African Americans) that underwent surgery as their primary treatment and had a benign prostate biopsy at least 1 year before diagnosis. CD3+, CD4+, and CD20+ lymphocytes were quantified by immunohistochemistry in paired pre- and post-diagnostic benign prostate biopsy and tumor surgical specimens, respectively...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38523340/lymphocytic-myocarditis-with-increased-left-ventricular-thickness-a-rare-presentation-mimicking-cardiac-amyloidosis
#36
JOURNAL ARTICLE
Xueting Duan, Liangzhen Qu, Han Chen
BACKGROUND Lymphocytic myocarditis is an inflammatory condition of the heart that may present with a wide spectrum of symptoms and signs, ranging from asymptomatic to life-threatening cardiogenic shock and ventricular arrhythmia. Lymphocytic myocarditis usually presents as chamber dilation. However, increased left ventricular thickness is relatively rare. We present a case of lymphocytic myocarditis with increased left ventricular thickness which mimics the presentation of cardiac amyloidosis. CASE REPORT An 80-year-old Chinese man presented to the emergency room due to recurrent chest tightness...
March 25, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38523032/bcl-2-inhibition-in-haematological-malignancies-clinical-application-and-complications
#37
REVIEW
Dominic J Fowler-Shorten, Charlotte Hellmich, Matthew Markham, Kristian M Bowles, Stuart A Rushworth
B-cell lymphoma-2 (BCL-2) family proteins are fundamental regulators of the intrinsic apoptotic pathway which modulate cellular fate. In many haematological malignancies, overexpression of anti-apoptotic factors (BCL-2, BCL-XL and MCL-1) circumvent apoptosis. To address this cancer hallmark, a concerted effort has been made to induce apoptosis by inhibiting BCL-2 family proteins. A series of highly selective BCL-2 homology 3 (BH3) domain mimetics are in clinical use and in ongoing clinical trials for acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL), and multiple myeloma (MM)...
March 21, 2024: Blood Reviews
https://read.qxmd.com/read/38522856/severe-liver-dysfunction-after-donor-lymphocyte-infusion-for-relapsed-multiple-myeloma
#38
Tae-Hoon No, Nae-Yun Heo, Seung Ha Park, Joon Hyuk Choi, Junghwan Lee, Sung Nam Lim, Seon Yang Park
Donor lymphocyte infusion (DLI) is performed to augment an anti-tumor immune response or ensure donor stem cells remain engrafted following allogeneic stem cell transplantation but may induce graft-versus-host disease (GVHD) involving skin, intestine, and liver. Although hepatic involvement of GVHD can manifest as mild to severe hepatitis, few reports have mentioned acute severe liver dysfunction with encephalopathy. We experienced a case of acute severe liver dysfunction with semicoma after DLI in a patient with relapsed multiple myeloma following allogeneic stem cell transplantation, in whom chronic viral hepatitis B had been suppressed by antiviral treatment...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38522565/astragalus-polysaccharides-ameliorates-experimental-colitis-by-regulating-memory-b-cells-metabolism
#39
JOURNAL ARTICLE
Yifei Deng, Lizhao Song, Jiaqi Huang, Wen Zhou, Yali Liu, Xiuyun Lu, Haimei Zhao, Duanyong Liu
It is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regulate MBCs to alleviate experimental colitis...
March 22, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38522010/b-cell-responses-and-antibody-based-therapeutic-perspectives-in-human-cancers
#40
REVIEW
Gunjan Mandal, Suchismita Pradhan
BACKGROUND: Immuno-oncology has been focused on T cell-centric approaches until the field recently started appreciating the importance of tumor-reactive antibody production by tumor-infiltrating plasma B cells, and the necessity of developing novel therapeutic antibodies for the treatment of different cancers. RECENT FINDINGS: B lymphocytes often infiltrate solid tumors and the extent of B cell infiltration normally correlates with stronger T cell responses while generating humoral responses against malignant progression by producing tumor antigens-reactive antibodies that bind and coat the tumor cells and promote cytotoxic effector mechanisms, reiterating the fact that the adaptive immune system works by coordinated humoral and cellular immune responses...
March 2024: Cancer reports
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