keyword
MENU ▼
Read by QxMD icon Read
search

bullous disease

keyword
https://www.readbyqxmd.com/read/29457514/relapse-of-bullous-pemphigoid-an-update-on-this-stubborn-clinical-problem
#1
Yiman Wang, Xuming Mao, Yanhong Wang, Yueping Zeng, Yidi Liu, Hongzhong Jin, Li Li
Bullous Pemphigoid (BP) is a chronic autoimmune blistering disorder that has a predilection for the elderly. It is characterized by a poor prognosis due to its high mortality rate and the tendency to relapse. The relapse rate of BP ranges from 27.87% to 53% after disease remission, while the majority of relapses occur early (within 6 months) during remission. Clinical interventions aimed to prevent early relapses could reduce potential complications from first-line treatment and make follow-up care easier for clinicians in practice, thus improving the prognosis of BP and the quality of patients' lives...
February 19, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29450379/pseudophakic-bullous-keratopathy
#2
REVIEW
Stefan Pricopie, Sanziana Istrate, Liliana Voinea, Costin Leasu, Vanessa Paun, Ciuluvica Radu
Pseudophakic bullous keratopathy is characterized by corneal stromal edema with epithelial and subepithelial bullae due to cell loss and endothelial decompensation through trauma during cataract surgery. Patients present decreased vision, tearing, and pain caused by ruptured epithelial bullae. Cataract affects approximately 20 million people worldwide, and this complication can occur in 1 to 2% of the cataract surgeries. This study reviewed the bullous keratopathy etiopathogenesis and the clinical and surgical treatment available for this corneal disease...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29447655/epidermolysis-bullosa-acquisita
#3
Gabriela Cobos, Euphemia Mu, Jeffrey Cohen, Jenna Beasley, Nooshin Brinster, Alisa Femia
Epidermolysis bullosa acquisita (EBA) is a rare, acquired subepidermal blistering disease. EBA is characterized by autoantibodies to collagen VII,which serves to link the epidermis to the dermis. The two most common presentations of EBA are classical noninflammatory EBA and bullous pemphigoid-like EBA. Diagnosis of EBA can be challenging as it sharesclinical and histopathologic features with other blistering diseases. Treatment is often recalcitrant and will often necessitate multiple therapies. We presenta case of a thirty-six-year-old Chinese man with EBA and review the literature...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447641/flame-figures-in-linear-iga-bullous-dermatosis-a-novel-histopathologic-finding
#4
E Fulton, F Jan, M J Zimarowski
BACKGROUND: Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease usually with a neutrophil rich inflammatory infiltrate, and characterized by linear IgA deposition at the basement membrane zone (BMZ), and neutrophil predominant dermal inflammation. We report a case of LABD with numerous eosinophils and flame figure formation, a unique histopathologic finding not previously reported. A 69-year-old woman presented with a rapidly progressive, intensely pruritic rash over forearms, breasts, axillae, hips, and thighs...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447635/sublamina-densa-type-linear-iga-bullous-dermatosis-with-iga-autoantibodies-specific-for-type-vii-collagen-a-case-report-and-clinicopathological-review-of-32-cases
#5
Natsuko Utsunomiya, Takenao Chino, Noritaka Oyama, Akira Utsunomiya, Yuka Yamaguchi, Wataru Takashima, Atsushi Tokuriki, Minoru Hasegawa
Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disorder characterized by linear deposits of IgA at the basement membrane zone(BMZ) and/or by circulating IgA anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents a heterogeneous disease entitywith diversity of pathogenic IgA autoantibodies to different hemidesmosomal antigens and an association with malignancies and occasional drug use. We herein present an 82-year-old Japanese man with LABD, whose indirect immunofluorescence using 1M NaCl-split skin showed positive staining for IgA at the dermal side alone...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29441293/mucocutaneous-manifestations-in-patients-with-chronic-kidney-disease-a-cross-sectional-study
#6
Rattan S Rashpa, Vikram K Mahajan, Pankaj Kumar, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat, Vikas Sharma
Background: Chronic kidney disease (CKD)-associated mucocutaneous manifestations significantly impair the quality of life but often remain understudied. They may also vary across regions, socioeconomic and nutritional status, and racial differences. Objectives: To study the patterns of mucocutaneous disorders and their prevalence in CKD patients irrespective of clinical stage or dialysis status. Materials and Methods: 122 (M:F = 77:45) patients aged 21‒85 (Mean ± SD = 57...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29440740/boston-keratoprosthesis-type-1-outcomes-of-the-first-38-cases-performed-at-moorfields-eye-hospital
#7
Chameen Samarawickrama, Nicholas Strouthidis, Mark R Wilkins
PURPOSE: To evaluate outcomes of Boston keratoprosthesis type 1 (K-Pro) surgery in a cohort of high-risk patients at Moorfields Eye Hospital. Our patients were referred to us at the end-point of their ocular disease. METHODS: A retrospective review of all K-Pro surgery performed between March 2011 and July 2015 with a minimum follow-up of 12 months. RESULTS: 39 eyes of 38 patients were included. Mean follow-up was 28.4 months (range: 12-56)...
February 14, 2018: Eye
https://www.readbyqxmd.com/read/29438767/diagnosis-and-management-of-pemphigus-recommendations-by-an-international-panel-of-experts
#8
Dedee F Murrell, Sandra Peña, Pascal Joly, Branka Marinovic, Takashi Hashimoto, Luis A Diaz, Animesh A Sinha, Aimee S Payne, Maryam Daneshpazhooh, Rüdiger Eming, Marcel F Jonkman, Daniel Mimouni, Luca Borradori, Soo-Chan Kim, Jun Yamagami, Julia S Lehman, Marwah Adly Saleh, Donna A Culton, Annette Czernik, John J Zone, David Fivenson, Hideyuki Ujiie, Katarzyna Wozniak, Ayşe Akman-Karakaş, Philippe Bernard, Neil J Korman, Frédéric Caux, Kossara Drenovska, Catherine Prost-Squarcioni, Snejina Vassileva, Ron J Feldman, Adela Rambi Cardones, Johann Bauer, Dimitrios Ioannides, Hana Jedlickova, Francis Palisson, Aikaterini Patsatsi, Soner Uzun, Savas Yayli, Detlef Zillikens, Masayuki Amagai, Michael Hertl, Enno Schmidt, Valeria Aoki, Sergei A Grando, Hiroshi Shimizu, Sharon Baum, Guiseppe Cianchini, Claudio Feliciani, Pilar Iranzo, Jose M Mascaró, Cezary Kowalewski, Russell Hall, Richard Groves, Karen E Harman, M Peter Marinkovich, Emanual Maverakis, Victoria P Werth
BACKGROUND: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations. METHODS: A preliminary survey, based on the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV) guidelines, was sent to a panel of international experts to determine the level of consensus...
February 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29429551/dermatology-and-immunoglobulin-therapy-who-to-treat-and-how-to-administer-immunoglobulins
#9
F J Navarro-Triviño, I Pérez-López, R Ruíz-Villaverde
Intravenous immunoglobulin (IVIG) replacement therapy has been used in immune deficiency diseases for more than 50 years. The indications for this treatment have evolved, however, and IVIG therapy is now used in various diseases in which the immune system plays a prominent role. IVIG therapy has carved out a niche in dermatology for the treatment of such conditions as dermatomyositis, autoimmune bullous diseases, and toxic epidermal necrolysis. Special attention has been paid to this therapy in recent years...
February 8, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29423547/bpdai-and-absis-correlate-with-serum-anti-bp180-nc16a-igg-but-not-with-anti-bp230-igg-in-patients-with-bullous-pemphigoid
#10
Maryam Daneshpazhooh, Maryam Ghiasi, Vahideh Lajevardi, Nafise Nasiri, Kamran Balighi, Amir Teimourpour, Hasan Khosravi, Vahide Saeidi, Hamidreza Mahmoudi, Cheyda Chams-Davatchi
Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by autoantibody production against BP180 and BP230. Two scoring systems have been validated for BP including: Bullous Pemphigoid Disease Area Index (BPDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). In this study, we investigated correlations between both scoring systems and either anti-BP180 NC16A or anti-BP230 values. BPDAI and ABSIS were used to measure disease activity in 95 BP patients at Razi Hospital in Tehran, Iran...
February 8, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29422810/a-case-of-pemphigus-vulgaris-associated-with-ulcerative-colitis
#11
Joo Wan Seo, Jongha Park, Jin Lee, Mi Young Kim, Hyun Ju Choi, Heui Jeong Jeong, Ji Woon Lee, So Young Jung, Woo Kyeong Kim
Pemphigus vulgaris is an autoimmune bullous disorder characterized by the production of autoantibodies against the intercellular space of the epithelium. It has rarely been reported in association with inflammatory bowel disease. Ulcerative colitis is one of the forms of inflammatory bowel disease. A 62-year-old woman who had been treated for ulcerative colitis for 16 years developed pruritic bullae on the skin of her face and body. Histological findings and direct immunofluorescence examination of the skin showed pemphigus vulgaris...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29411416/decrease-in-eosinophils-infiltrating-into-the-skin-of-patients-with-dipeptidyl-peptidase-4-inhibitor-related-bullous-pemphigoid
#12
Chika Chijiwa, Shintaro Takeoka, Masahiro Kamata, Mihoko Tateishi, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Shinichi Watanabe, Yayoi Tada
Bullous pemphigoid (BP) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP180 or BP230 are produced. Dipeptidyl peptidase (DPP)-4 inhibitors have become commonly used to treat diabetes. As DPP-4 inhibitors are more commonly prescribed for diabetes, BP related to DPP-4 inhibitors has been reported and has attracted attention. Therefore, we retrospectively investigated patients who were diagnosed with BP in order to examine characteristics of DPP-4 inhibitor-related BP (nine patients; median age, 85 years) in comparison with non-DPP-4 inhibitor-related BP (21; median age, 85 years)...
February 6, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29410297/trends-in-corneal-transplantation-from-2001-to-2016-in-germany-a-report-of-the-dog-section-cornea-and-its-keratoplasty-registry
#13
E Flockerzi, P Maier, D Böhringer, H Reinshagen, F Kruse, C Cursiefen, T Reinhard, G Geerling, N Torun, B Seitz
PURPOSE: The purpose of this retrospective panel study was to provide an overview of absolute numbers, trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016. METHODS: A questionnaire about absolute numbers, types of transplantation and indications was sent to 111 ophthalmological departments in Germany out of which 94 (85%) provided their data. RESULTS: Since the year 2001, the number of corneal transplantations has increased by 1...
February 1, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29410066/vancomycin-mediates-iga-autoreactivity-in-drug-induced-linear-iga-bullous-dermatosis
#14
Jun Yamagami, Yoshio Nakamura, Keisuke Nagao, Takeru Funakoshi, Hayato Takahashi, Akiko Tanikawa, Takahisa Hachiya, Toshiyuki Yamamoto, Akemi Ishida-Yamamoto, Toshihiro Tanaka, Noriki Fujimoto, Chikako Nishigori, Tetsuya Yoshida, Norito Ishii, Takashi Hashimoto, Masayuki Amagai
Vancomycin (VCM) is known to induce linear IgA bullous dermatosis (LAD). However, in contrast to conventional LAD, in which circulating IgA autoantibodies against basement membrane proteins are commonly detected, patient sera from VCM-induced LAD (vLAD) yields negative results in indirect immunofluorescence microscopy, and the targeted autoantigen remains undetermined. By utilizing sera from a typical case of vLAD, we identified that co-incubation of sera with VCM resulted in linear IgA deposition at the basement membrane zone (BMZ) by indirect immunofluorescence...
January 31, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29407691/detection-of-%C3%AE-defensin-in-blister-fluids-as-potential-biomarkers-for-bullous-pemphigoid-patients-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#15
Ching-Ying Wu, Li-Hua Lo, Hung Su, Jentaie Shiea
BACKGROUND: Bullous pemphigoid (BP) is a chronic blistering disease that manifests as multiple tense bullae on the limbs and body. Detecting biomarkers present in skin fluids may assist in the early diagnosis and treatment of BP. In this study, a modern mass spectrometric method was developed for screening biomarkers in blister fluids collected from patients. METHODS: Blister fluids collected from BP patients and physically injured patients were analyzed and compared using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)...
January 29, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29392636/dry-eye-and-meibomian-gland-dysfunction-in-pseudophakic-bullous-keratopathy
#16
Melis Palamar, Pelin Kiyat, Ayse Yagci
PURPOSE: To evaluate dry eye tests and meibography of patients with pseudophakic bullous keratopathy (PBK). MATERIALS AND METHODS: Thirty-seven patients with PBK were included. The eyes with PBK were compared with the normal pseudophakic fellow eyes. All patients had undergone a detailed ophthalmic examination including corneal and conjunctival fluorescein staining and Oxford scoring, tear film breakup time, Schirmer 1 test, Ocular Surface Disease Index (OSDI) score assessment, lid margin abnormalities, upper and lower eyelid Meibomian gland evaluation using infrared captures of a biomicroscope...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29392620/treatment-of-autoimmune-bullous-disorders-in-pregnancy
#17
REVIEW
Carolyn J Kushner, Josef Symon S Concha, Victoria P Werth
Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations...
February 2, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29391715/immunofluorescence-in-oral-lesions
#18
REVIEW
S J Nithya, R Sankarnarayanan, V T Hemalatha, T Sarumathi
Immunofluorescence is an immunohistochemical method used to demonstrate the presence of antigen and antibodies in the tissues or serum. It is an auxiliary diagnostic tool for the autoimmune bullous and inflammatory disorders. It detects the in situ and circulating immune deposits that are involved in the pathogenesis of immunobullous diseases.
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29391250/intravenous-immunoglobulin-reduces-pathogenic-autoantibodies-serum-il-6-levels-and-disease-severity-in-experimental-bullous-pemphigoid-models
#19
Tetsumasa Sasaoka, Hideyuki Ujiie, Wataru Nishie, Hiroaki Iwata, Makoto Ishikawa, Hiroshi Higashino, Ken Natsuga, Satoru Shinkuma, Hiroshi Shimizu
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies to type XVII collagen (COL17). Currently, systemic corticosteroids are used as first-line treatments for BP; alternatively, intravenous administration of high-dose IgG (IVIG) has been shown to be effective for patients with steroid-resistant BP in clinical practice. However, the effect of IVIG on BP has not fully been investigated. To examine the effects and mechanisms of action of IVIG against BP we performed IVIG experiments using two experimental BP mouse models...
January 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29386827/mortality-and-comorbidity-profiles-of-patients-with-bullous-pemphigoid-in-korea
#20
Hyeon Woo Jeon, Sook Jung Yun, Seung-Chul Lee, Young Ho Won, Jee-Bum Lee
Background: Bullous pemphigoid (BP) is a common autoimmune-mediated blistering skin disease that is significantly associated with mortality and morbidity. However, few studies regarding the mortality and comorbidity profiles of BP have been reported in Korea. Objective: To evaluate and compare the mortality, comorbidity profiles, and risk factors between patients with BP who visited our clinic and an age-matched general population of Korea. Methods: We retrospectively evaluated 103 patients diagnosed with BP between 2006 and 2013 at Chonnam National University Hospital in Gwangju, Korea...
February 2018: Annals of Dermatology
keyword
keyword
70568
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"