keyword
https://read.qxmd.com/read/38699454/novel-missense-variants-in-brain-morphogenic-genes-associated-with-depression-and-schizophrenia
#21
JOURNAL ARTICLE
Maxim Karagyaur, Alexandra Primak, Kirill Bozov, Dmitriy Sheleg, Mikhail Arbatsky, Stalik Dzhauari, Maria Illarionova, Ekaterina Semina, Larisa Samokhodskaya, Polina Klimovich, Arkadiy Velichko, Mikhail Drach, Ekaterina Sotskaya, Vladimir Popov, Kseniya Rubina, Mariia Parfenenko, Julia Makus, Boris Tsygankov, Vsevolod Tkachuk, Elena Neyfeld
INTRODUCTION: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). Identification of such genes (genes of neurotrophic factors and guidance molecules among them) and their deleterious genetic variants serves as a key to diagnosis, prevention, and possibly treatment of such disorders. In this study, we have examined the prevalence of genomic variants in brain morphogenic genes in individuals with SCZ and MDD within a Russian population...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38699304/contribution-of-autosomal-rare-and-de-novo-variants-to-sex-differences-in-autism
#22
Mahmoud Koko, F Kyle Satterstrom, Varun Warrier, Hilary Martin
Autism is four times more prevalent in males than females. To study whether this reflects a difference in genetic predisposition attributed to autosomal rare variants, we evaluated the sex differences in effect size of damaging protein-truncating and missense variants on autism predisposition in 47,061 autistic individuals, then compared effect sizes between individuals with and without cognitive impairment or motor delay. Although these variants mediated differential likelihood of autism with versus without motor or cognitive impairment, their effect sizes on the liability scale did not differ significantly by sex exome-wide or in genes sex-differentially expressed in the cortex...
April 16, 2024: medRxiv
https://read.qxmd.com/read/38697041/motoric-cognitive-risk-syndrome-as-a-predictor-of-adverse-health-outcomes-a-systematic-review-and-meta-analysis
#23
Cheng Huang, Bei Wu, Chen Zhang, Zhuqin Wei, Liming Su, Junwei Zhang, Lina Wang
INTRODUCTION: Motoric cognitive risk syndrome (MCR) is a newly proposed pre-dementia syndrome characterized by subjective cognitive complaints (SCC) and slow gait (SG). Increasing evidence links MCR to several adverse health outcomes, but the specific relationship between MCR and the risk of frailty, Alzheimer's disease (AD) and vascular dementia (VaD) remains unclear. Additionally, literature lacks analysis of MCR's components and associated health outcomes, complicating risk identification...
May 2, 2024: Gerontology
https://read.qxmd.com/read/38695811/state-anticipation-and-task-serialization-attenuate-embodied-decision-biases-when-deciding-while-moving
#24
JOURNAL ARTICLE
Philipp Raßbach, Eric Grießbach, Rouwen Cañal-Bruland, Oliver Herbort
We examined whether and how embodied decision biases-related to motor costs (MC) as well as cognitive crosstalk (CC) due to the body state-are influenced by extended deliberation time. Participants performed a tracking task while concurrently making reward-based decisions, with rewards being presented with varying preview time. In Experiment 1 ( N = 58), we observed a reduced CC bias with extended preview time. Partially, this was due to participants slightly adapting tracking to serialize it in relation to decision making...
May 2, 2024: Journal of Experimental Psychology. Human Perception and Performance
https://read.qxmd.com/read/38695025/the-impact-of-spiritual-care-on-the-psychological-health-and-quality-of-life-of-adults-with-heart-failure-a-systematic-review-of-randomized-trials
#25
Guangwei Zhang, Qiyu Zhang, Fan Li
BACKGROUND: Heart failure (HF) brings not only physical pain but also psychological distress. This systematic review investigated the influence of spiritual care on the psychological well-being and quality of life in adults with HF. METHODS: We conducted a systematic literature review following PRISMA guidelines, searching seven electronic databases for relevant randomized controlled studies without language or temporal restrictions. The studies were assessed for quality using the Cochrane Bias Risk tool...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38694439/developing-trustworthy-artificial-intelligence-insights-from-research-on-interpersonal-human-automation-and-human-ai-trust
#26
REVIEW
Yugang Li, Baizhou Wu, Yuqi Huang, Shenghua Luan
The rapid advancement of artificial intelligence (AI) has impacted society in many aspects. Alongside this progress, concerns such as privacy violation, discriminatory bias, and safety risks have also surfaced, highlighting the need for the development of ethical, responsible, and socially beneficial AI. In response, the concept of trustworthy AI has gained prominence, and several guidelines for developing trustworthy AI have been proposed. Against this background, we demonstrate the significance of psychological research in identifying factors that contribute to the formation of trust in AI...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38694114/opportunity-abandonment-why-are-entrepreneurs-vulnerable-to-type-i-and-ii-errors
#27
JOURNAL ARTICLE
Tahseen Anwer Arshi, Venkoba Rao, Atif Saleem Butt
Opportunity actualization is a critical competency attributed to entrepreneurs, which has received widespread attention in the entrepreneurship literature. However, the knowledge of Entrepreneurial Opportunity Abandonment (EOA) decisions is limited. We, therefore, explore the relatively under-studied EOA, analyzing why entrepreneurs commit decision errors, abandon potentially viable opportunities (type I error) or pursue non-opportunity spaces (type II error), and ultimately forsake them later. Through a scoping literature review, we highlight more profound psychological variables that shape entrepreneurial opportunity behavior triggering EOA decisions...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38693727/probability-cost-and-interpretation-biases-relationships-with-depressive-and-anxious-symptom-severity-differential-mediation-by-worry-and-repetitive-negative-thinking
#28
JOURNAL ARTICLE
Robert W Booth, Bundy Mackintosh, Servet Hasşerbetçi
People high in depressive or anxious symptom severity show repetitive negative thinking, including worry and rumination. They also show various cognitive phenomena, including probability, cost, and interpretation biases. Since there is conceptual overlap between these cognitive biases and repetitive negative thinking - all involve thinking about potential threats and misfortunes - we wondered whether repetitive negative thinking could account for (mediate) these cognitive biases' associations with depressive and anxious symptom severity...
May 1, 2024: Cognition & Emotion
https://read.qxmd.com/read/38693547/an-acute-phase-reaction-from-zoledronate-mimicking-symptoms-seen-in-opioid-withdrawal-a-case-report
#29
JOURNAL ARTICLE
Pankti P Acharya, Crystal Joseph
BACKGROUND: Zoledronate, a bisphosphonate, is a potent first-line treatment for osteoporosis. It is also a preferred treatment for hypercalcemia especially when unresponsive to intravenous fluids. Bisphosphonates can cause acute phase reactions that mimic opioid withdrawal symptoms, which can confound provider decision-making. Our case highlights cognitive bias involving a patient with opioid use disorder who received zoledronate for hypercalcemia secondary to immobilization and significant bone infection...
May 1, 2024: Addiction Science & Clinical Practice
https://read.qxmd.com/read/38692414/title-systematic-review-and-meta-analysis-on-the-effectiveness-of-multidisciplinary-interventions-to-address-polypharmacy-in-community-dwelling-older-adults
#30
REVIEW
Victoria Roncal-Belzunce, Marta Gutierrez-Valencia, Leire Leache, Luis Carlos Saiz, J Simon Bell, Juan Erviti, Nicolás Martínez-Velilla
Interventions to address polypharmacy in community-dwelling older adults often focus on medication-related outcomes. The aim was to explore the impact of multidisciplinary interventions to manage polypharmacy on clinical outcomes for community-dwelling older adults. This systematic review and meta-analysis included randomized controlled trials (RCTs) on interventions by at least a pharmacist and a physician, indexed in MEDLINE, EMBASE or CENTRAL up to January 2023. Evidence certainty was assessed using the GRADE approach...
April 29, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38692156/what-exercise-strategies-are-best-for-people-with-cognitive-impairment-and-dementia-a-systematic-review-and-meta-analysis
#31
REVIEW
Zecheng Li, Hongpeng Guo, Xuebin Liu
OBJECTIVE: Explore the types of exercise that are appropriate for people with dementia, as well as the intensity and frequency of exercise training that is appropriate for older patients to carry out. METHODS: Cochrane Library, PubMed, Embase, Web of Science, Scopus databases were searched by computer to collect RCT studies that met the inclusion criteria of this article. The search time limit was until January 2024. Two reviewers independently screened literature, extracted data, and assessed the quality and risk of bias of the included studies...
April 21, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38691938/treatment-with-inhaled-argon-a-systematic-review-of-pre-clinical-and-clinical-studies-with-meta-analysis-on-neuroprotective-effect
#32
JOURNAL ARTICLE
Giulia Merigo, Gaetano Florio, Fabiana Madotto, Aurora Magliocca, Ivan Silvestri, Francesca Fumagalli, Marianna Cerrato, Francesca Motta, Daria De Giorgio, Mauro Panigada, Alberto Zanella, Giacomo Grasselli, Giuseppe Ristagno
BACKGROUND: Argon (Ar) has been proposed as a potential therapeutic agent in multiple clinical conditions, specifically in organ protection. However, conflicting data on pre-clinical models, together with a great variability in Ar administration protocols and outcome assessments, have been reported. The aim of this study was to review evidence on treatment with Ar, with an extensive investigation on its neuroprotective effect, and to summarise all tested administration protocols. METHODS: Using the PubMed database, all existing pre-clinical and clinical studies on the treatment with Ar were systematically reviewed (registration: https://doi...
April 30, 2024: EBioMedicine
https://read.qxmd.com/read/38691540/is-there-a-bilingual-advantage-in-auditory-attention-among-children-a-systematic-review-and-meta-analysis-of-standardized-auditory-attention-tests
#33
JOURNAL ARTICLE
Wenfu Bao, Claude Alain, Michael Thaut, Monika Molnar
A wealth of research has investigated the associations between bilingualism and cognition, especially in regards to executive function. Some developmental studies reveal different cognitive profiles between monolinguals and bilinguals in visual or audio-visual attention tasks, which might stem from their attention allocation differences. Yet, whether such distinction exists in the auditory domain alone is unknown. In this study, we compared differences in auditory attention, measured by standardized tests, between monolingual and bilingual children...
2024: PloS One
https://read.qxmd.com/read/38690176/efficacy-and-safety-of-the-ayurvedic-herbal-preparation-maharishi-amrit-kalash-a-systematic-review-of-randomized-controlled-trials
#34
Anna K Koch, Manish Patel, Shivenarain Gupta, Ricarda Wullenkord, Michael Jeitler, Christian S Kessler
BACKGROUND: Maharishi Amrit Kalash (MAK) 4 and 5 are Ayurvedic herbal nutritional supplements that are believed to have beneficial effects on overall health and wellbeing. This study aimed to systematically review all available randomized controlled trials (RCTs) investigating the clinical effects and safety of MAK. METHODS: We included RCTs on therapy, health promotion, and prevention for patients and healthy volunteers of all ages. We systematically searched MEDLINE (via PubMed), EMBASE (via Ovid), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), DHARA, Clinicaltrials...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38688821/not-just-emotion-regulation-but-cognition-an-experience-sampling-study-testing-the-relations-of-ecological-interpretation-biases-and-use-of-emotion-regulation-strategies-with-momentary-affective-states-during-daily-life-functioning
#35
JOURNAL ARTICLE
Teresa Boemo, Oscar Martín-Garcia, Ana Mar Pacheco-Romero, Ivan Blanco, Ginette Lafit, Inez Myin-Germeys, Alvaro Sanchez-Lopez
BACKGROUND: Current research is moving from studying cognitive biases and maladaptive emotion regulation (ER) as relatively stable phenomena contributing to affective disturbances, adopting ecological methodologies, such as Experience Sampling Methods (ESM). However, there is still limited ESM evidence on the interactions between stress and ER strategies' use, and negative interpretation biases, regarding their relations with momentary affective states. In this study, we used a new ESM design to disentangle the contextual, regulatory and cognitive processes implicated in daily affective experiences...
April 25, 2024: Behaviour Research and Therapy
https://read.qxmd.com/read/38688669/effect-of-visual-impairment-on-subjective-cognitive-decline-in-older-adults-a-cross-sectional-study-in-china
#36
JOURNAL ARTICLE
Liyan Luo, Ning Jiang, Xiaolei Zheng, Ping Wang, Jianzhong Bi, Feng Xu, Zhaohong Xie, Liping Yang
OBJECTIVE: People with visual impairment have more functional limitations associated with subjective cognitive decline (SCD), and those with SCD are extremely susceptible to transitioning to irreversible cognitive impairment. This study aimed to explore if visual impairment is a significant predictor of SCD compared with other socioeconomic and health factors associated with SCD. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: The investigation aimed to assess the factors influencing SCD among 428 participants aged 60 and above in Zhaoyuan, China...
April 30, 2024: BMJ Open
https://read.qxmd.com/read/38686721/-process-approach-in-memory-assessment-of-patients-with-alzheimer-s-disease-and-mild-cognitive-impairment-a-review
#37
REVIEW
Wen-Hao Zhu, Zhon-Gwu Sun
The process approach,a set of analytical methods used in neuropsychology,quantifies the word-list learning tests and conventional analytical methods and fully reflects the memory profile of the subject.Therefore,it is widely used in the memory assessment of patients with Alzheimer's disease(AD)and mild cognitive impairment(MCI).The common indices of process approach,such as learning slope,semantic clustering,serial position effects,discriminability,and response bias,are key components of memory assessment.This article reviews the application of common indices of process approach in memory assessment of AD and MCI patients and discusses the shortcomings and future research directions of process approach...
April 2024: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://read.qxmd.com/read/38686327/effects-of-movement-training-based-on-rhythmic-auditory-stimulation-in-cognitive-impairment-a-meta-analysis-of-randomized-controlled-clinical-trial
#38
REVIEW
Ya Nan Wang, Xiao Ni Wen, Yu Chen, Nuo Xu, Jing Han Zhang, Xue Hou, Jing Ping Liu, Ping Li, Jia Yu Chen, Jun Hao Wang, Xin Yue Sun
OBJECTIVE: According to the World Alzheimer's Disease Report in 2015,there were 9.9 million new cases of dementia in the world every year. At present, the number of patients suffering from dementia in China has exceeded 8 million, and it may exceed 26 million by 2040.Mild cognitive impairment (MCI) refers to the pathological state of pre-dementia with the manifestation of the progressive decline of memory or other cognitive functions but without decline of activities of daily life. It is particularly important to prevent or prolong the development of MCI into dementia...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38686120/comparison-of-changes-in-stress-coping-strategies-between-cognitive-behavioral-therapy-and-pharmacotherapy
#39
JOURNAL ARTICLE
Sakae Ihara, Nariko Katayama, Waka Nogami, Mizuki Amano, Sachiko Noda, Chika Kurata, Yuki Kobayashi, Yohei Sasaki, Dai Mitsuda, Mire Ozawa, Jun Matsuoka, Ryo Takemura, Hiroyuki Uchida, Atsuo Nakagawa
BACKGROUND: Coping refers to conscious responses to negative circumstances, with the intention of ameliorating these situations. Few studies have compared the differences between psychotherapy and medication treatment for coping strategies for depression. In this study, we investigated the differences in coping strategies between cognitive behavioral therapy (CBT) combined with medication (CBT group) and medication alone (pharmacotherapy group) among outpatients with depression. METHODS: A prospective observational study was conducted among 50 patients with major depression (24 and 26 in the CBT and pharmacotherapy groups, respectively)...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38685952/role-of-serum-neuron-specific-enolase-levels-in-the-early-diagnosis-and-prognosis-of-sepsis-associated-encephalopathy-a-systematic-review-and-meta-analysis
#40
MengQin Pei, YuShen Yang, ChunYan Zhang, QiaoMei Huang, YuMing Fang, LiMing Xu, Shu Lin, HeFan He
BACKGROUND: Sepsis-associated encephalopathy (SAE) is one of the most ubiquitous complications of sepsis and is characterized by cognitive impairment, poor prognosis, and a lack of uniform clinical diagnostic criteria. Therefore, this study investigated the early diagnostic and prognostic value of serum neuron-specific enolase (NSE) in SAE. METHODS: This systematic review and meta-analysis systematically searched for clinical trials with serum NSE information in patients with sepsis in the PubMed, Web of Science, Embase, and Cochrane databases from their inception to April 10, 2023...
2024: Frontiers in Neurology
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