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https://www.readbyqxmd.com/read/29912944/increasing-success-and-evolving-barriers-in-the-hepatitis-c-cascade-of-care-during-the-direct-acting-antiviral-era
#1
Autumn Zuckerman, Andrew Douglas, Sam Nwosu, Leena Choi, Cody Chastain
Barriers remain in the hepatitis C virus (HCV) cascade of care (CoC), limiting the overall impact of direct acting antivirals. This study examines movement between the stages of the HCV CoC and identifies reasons why patients and specific patient populations fail to advance through care in a real world population. We performed a single-center, ambispective cohort study of patients receiving care in an outpatient infectious diseases clinic between October 2015 and September 2016. Patients were followed from treatment referral through sustained virologic response...
2018: PloS One
https://www.readbyqxmd.com/read/29912062/uptake-of-hcv-treatment-in-hiv-hcv-coinfected-patients-across-europe-in-the-era-of-direct-acting-antivirals
#2
Lars Peters, Kamilla Laut, Chiara Resnati, Santos Del Campo, Clifford Leen, Karolin Falconer, Tatyana Trofimova, Dzmitry Paduta, Jose Gatell, Andri Rauch, Karine Lacombe, Pere Domingo, Nikoloz Chkhartishvili, Robert Zangerle, Raimonda Matulionyte, Viktar Mitsura, Thomas Benfield, Kai Zilmer, Irina Khromova, Jens Lundgren, Jürgen Rockstroh, Amanda Mocroft
BACKGROUND AND AIMS: To investigate the uptake of HCV therapy among HIV/HCV coinfected patients in the pan-European EuroSIDA study between 2011-2016. METHODS: All HCV-RNA+ patients were included. Baseline was defined as latest of anti-HCV+, January 2011 or enrolment in EuroSIDA. The incidence of starting first IFN-free direct-acting antiviral (DAA) therapy was calculated. Factors associated with starting IFN-free DAA were determined by Poisson regression. RESULTS: Among 4308 HCV-RNA+ patients (1255, 970, 663, 633, 787 from South, West, North, Central East and East Europe, respectively) with 11863 person years of follow up (PYFU), 1113 (25...
June 14, 2018: AIDS
https://www.readbyqxmd.com/read/29912046/changes-in-utilization-and-discard-of-hcv-antibody-positive-deceased-donor-kidneys-in-the-era-of-direct-acting-antiviral-therapy
#3
Mary G Bowring, Lauren M Kucirka, Allan B Massie, Tanveen Ishaque, Sunjae Bae, Ashton A Shaffer, Jacqueline Garonzik Wang, Mark Sulkowski, Niraj Desai, Dorry L Segev, Christine M Durand
BACKGROUND: The availability of direct-acting antiviral (DAA) therapy might have impacted use of HCV-infected (HCV+) deceased-donor kidneys for transplantation. METHODS: We used 2005-2018 SRTR data to identify 18 936 candidates willing to accept HCV+ kidneys and 3348 HCV+ recipients of HCV+ kidneys. We compared willingness to accept, utilization, discard, and posttransplant outcomes associated with HCV+ kidneys between 2 treatment eras (Interferon [IFN] era: 1/1/2005-12/5/2013 versus DAA era: 12/6/2013-8/2/2018)...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29911076/decreased-hepatocellular-carcinoma-tumor-burden-with-the-achievement-of-hepatitis-c-virus-sustained-virologic-response-unlocking-the-potential-of-t-cell-mediated-immunosurveillance
#4
Anna S Griffith, Paul H Hayashi, Lauren Mb Burke, Autumn J McRee
We describe two cases of patients with hepatitis C virus (HCV) treated with direct-acting antiviral (DAA) therapy who had dramatic improvement in hepatocellular carcinoma (HCC) tumor burden with DAA therapy alone. Both patients were diagnosed with HCC on screening magnetic resonance imaging shortly after beginning DAA therapy. Both patients achieved sustained virologic response (SVR) with dramatic improvement in HCC tumor burden on follow-up imaging without HCC treatment. Patients with multifocal or advanced HCC are infrequently treated with antiviral therapy for HCV...
2018: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/29909874/state-medicaid-reimbursement-for-medications-for-chronic-hepatitis-c-infection-from-2012-through-2015
#5
Christine Y Lu, Fang Zhang, Nicole Golonski, Caitlin Lupton, Paul Jeffrey, Anita K Wagner
BACKGROUND: New direct-acting antivirals (DAAs) can cure chronic hepatitis C virus (HCV) infection. High DAA prices combined with a large number of patients needing treatment may pose substantial economic burden on health systems. OBJECTIVES: To examine Medicaid reimbursement for medications for HCV infection before and after the availability of new DAAs overall and by state and to also assess the impact of Medicaid expansion on reimbursement for DAAs. METHODS: We calculated Medicaid reimbursements for medications for HCV infection between 2012 and 2015 in all 50 states and the District of Columbia...
June 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29909549/pharmacokinetics-of-ombitasvir-paritaprevir-ritonavir-and-dasabuvir-in-healthy-chinese-subjects-and-hcv-gt1b-infected-chinese-south-korean-and-taiwanese-patients
#6
Jiuhong Zha, Bifeng Ding, Haoyu Wang, Weihan Zhao, Chen Yu, Katia Alves, Niloufar Mobashery, Yan Luo, Rajeev M Menon
BACKGROUND/PURPOSE: The 3 direct-acting antiviral (3D) regimen of ombitasvir/paritaprevir/ritonavir plus dasabuvir has recently been approved in several Asian geographic regions for the treatment of hepatitis C virus (HCV) genotype (GT) 1 infection. The pharmacokinetics of the components of the 3D regimen with or without ribavirin were evaluated in healthy Chinese subjects and HCV GT1b-infected Chinese, South Korean, and Taiwanese patients, with or without cirrhosis, to determine how the drug exposures in Asian populations compare with historical data in Western populations...
June 16, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29903795/hepatitis-c-virus-infection-and-hospital-related-outcomes-a-systematic-review-protocol
#7
Lianping Ti, Michelle Ng, Lindila Awendila, Patrizia Maria Carrieri
INTRODUCTION: People living with hepatitis C virus (HCV) infection are disproportionately over-represented in the healthcare system due to various individual and contextual circumstances, including comorbidities and socioeconomic marginalisation. With growing trends in morbidity and mortality related to HCV infection, HCV is becoming a significant health and financial burden on the healthcare system, particularly in acute hospital settings. It is noteworthy that with the advent of direct-acting antiviral therapy the increasing number of patients who are cured of HCV could potentially result in different patterns of hospital-related outcomes over time...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29902392/a-surveillance-based-hepatitis-c-care-cascade-new-york-city-2017
#8
Miranda S Moore, Angelica Bocour, Fabienne Laraque, Ann Winters
OBJECTIVES: The care cascade, a method for tracking population-level progression from diagnosis to cure, is an important tool in addressing and monitoring the hepatitis C virus (HCV) epidemic. However, little agreement exists on appropriate care cascade steps or how best to measure them. The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) sought to construct a care cascade by using laboratory surveillance data with clinically relevant categories that can be readily updated over time...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29900836/-risk-of-hepatocellular-carcinoma-after-hepatitis-c-virus-cure-with-direct-acting-antivirals-the-next-challenges
#9
Nourdine Hamdane, Thomas F Baumert, Mirjam B Zeisel
No abstract text is available yet for this article.
May 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29899985/effectiveness-and-safety-of-sofosbuvir-ledipasvir-%C3%A2-ribavirin-treatment-in-liver-and-or-renal-transplant-patients-with-chronic-hepatitis-c-a-single-center-experience
#10
Mete Akin, Osman Cagin Buldukoglu, Haydar Adanir, Inci Suleymanlar, Dinc Dincer, Bulent Yildirim
Objective: Successful treatment is possible with novel direct-acting oral antiviral agents in solid organ transplant patients with hepatitis C. In this study, the effectiveness and safety of sofosbuvir/ledipasvir ± ribavirin treatment in liver and/or renal transplant patients with chronic hepatitis C were evaluated. Materials and methods: A total of 23 liver and/or renal transplant patients who received sofosbuvir/ledipasvir ± ribavirin for chronic hepatitis C over 12 or 24 weeks were enrolled in the study...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29893709/svr-24-achievement-two-weeks-after-a-tripled-dose-of-daclatasvir-in-an-hcv-genotype-3-patient
#11
Sara Lo Menzo, Enrico Biagi, Mariachiara Di Nuzzo, Anastasio Grilli, Carlo Contini
Directly-acting antivirals (DAA) have changed the chronic hepatitis C virus (HCV) infection therapeutic scenario allowing virus eradication in more than 95% of patients, independently from the genotype, with 12 to 24-week treatment regimens. We describe a 51-year-old Pakistani man with a chronic HCV-genotype 3 (GT3a) infection with moderate liver fibrosis, who achieved sustained virological response (SVR) 24 after a tripled dose of Daclatasvir (DCV) taken erroneously associated to Sofosbuvir (SOF). The patient had a concomitant intestinal TB infection whose treatment had been delayed in order to firstly eradicate HCV to reduce the liver toxicity of anti-mycobacterial drugs...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893462/viral-eradication-is-required-for-sustained-improvement-of-patient-reported-outcomes-in-patients-with-hepatitis-c
#12
Zobair M Younossi, Maria Stepanova, K Rajender Reddy, Michael P Manns, Marc Bourliere, Stuart C Gordon, Eugene Schiff, Tram Tran, Issah Younossi, Andrei Racila
BACKGROUND: Clearance of chronic HCV infection improves quality of life and other patient-reported outcomes (PROs). Lack of placebo-controlled data led to concerns about the extent of contribution of viral eradication to PRO improvement. AIM: To assess PRO changes in HCV patients initially randomized to placebo treatment who received SOF/VEL/VOX in a deferred treatment sub-study. METHODS: HCV-infected direct-acting antivirals-experienced patients who received placebo treatment in POLARIS-1 subsequently received SOF/VEL/VOX (400mg/100mg/100mg) daily for 12 weeks...
June 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29892184/hepatitis-c-virus-infection-and-vaccine-development
#13
REVIEW
Xuan Guo, Jin-Yi Zhong, Jun-Wen Li
In the twenty-seven years since the discovery of hepatitis C virus (HCV) the majority of individuals exposed to HCV establish a persistent infection, which is a leading cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In developed nations, the cure rates of HCV infection could be over 90% with direct-acting antiviral (DAA) regimens, which has made the great progress in global eradication. However, the cost of these treatments is so expensive that the patients in developing nations, where the disease burden is the most severe, could not afford it, which highly restricted its access...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29888827/real-world-outcomes-of-unrestricted-direct-acting-antiviral-treatment-for-hepatitis-c-in-australia-the-south-australian-statewide-experience
#14
James Haridy, Alan Wigg, Kate Muller, Jeyamani Ramachandran, Emma Tilley, Victoria Waddell, David Gordon, David Shaw, Dep Huynh, Jeffrey Stewart, Renjy Nelson, Morgyn Warner, Mark Boyd, Mohamed A Chinnaratha, Damian Harding, Lucy Ralton, Anton Colman, Danny Liew, Guru Iyngkaran, Edmund Tse
In March 2016, the Australian government offered unrestricted access to direct-acting antiviral (DAA) therapy for chronic hepatitis C (HCV) to the entire population. This included prescription by any medical practitioner in consultation with specialists until sufficient experience was attained. We sought to determine the outcomes and experience over the first twelve-months for the entire state of South Australia. We performed a prospective, observational study following outcomes of all treatments associated with the state's four main tertiary centres...
June 11, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29888208/risk-of-de-novo-hepatocellular-carcinoma-after-hcv-treatment-with-direct-acting-antivirals
#15
Fabian Finkelmeier, Georg Dultz, Kai-Henrik Peiffer, Bernd Kronenberger, Franziska Krauss, Stefan Zeuzem, Christoph Sarrazin, Johannes Vermehren, Oliver Waidmann
Background and Aims: The aim of the study was to evaluate the risk of hepatocellular carcinoma (HCC) development after treatment with direct-acting antivirals (DAAs) and to compare HCC occurrence in these patients with that among patients treated with interferon (IFN)-based therapies. Methods: We analyzed a large cohort with chronic hepatitis C virus patients for the onset of new HCC after DAA treatment. A historical IFN-treated cohort was investigated for comparison...
May 2018: Liver Cancer
https://www.readbyqxmd.com/read/29886373/a-near-full-length-open-reading-frame-next-generation-sequencing-assay-for-genotyping-and-identification-of-resistance-associated-variants-in-hepatitis-c-virus
#16
M S Pedersen, U Fahnøe, T A Hansen, A G Pedersen, H Jenssen, J Bukh, K Schønning
BACKGROUND: The current treatment options for hepatitis C virus (HCV), based on direct acting antivirals (DAA), are dependent on virus genotype and previous treatment experience. Treatment failures have been associated with detection of resistance-associated substitutions (RASs) in the DAA targets of HCV, the NS3, NS5A and NS5 B proteins. OBJECTIVE: To develop a next generation sequencing based method that provides genotype and detection of HCV NS3, NS5A, and NS5 B RASs without prior knowledge of sample genotype...
June 1, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29880964/nash-leading-cause-of-liver-transplant-in-women-updated-analysis-of-indications-for-liver-transplant-and-ethnic-and-gender-variances
#17
Mazen Noureddin, Aarshi Vipani, Catherine Bresee, Tsuyoshi Todo, Irene K Kim, Naim Alkhouri, Veronica Wendy Setiawan, Tram Tran, Walid S Ayoub, Shelly C Lu, Andrew S Klein, Vinay Sundaram, Nicholas N Nissen
OBJECTIVES: Chronic infection with hepatitis C virus (HCV) was previously the leading indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-acting antivirals (DAAs) has decreased the chronic HCV burden, while the prevalence of nonalcoholic steatohepatitis (NASH) has risen substantially through the last decade. Both gender and ethnic disparities in indications for LT have been shown in the past but no data on this have been reported since the implementation of DAAs...
June 8, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29880625/ombitasvir-paritaprevir-ritonavir-plus-dasabuvir-regimen-may-be-used-safely-in-combination-with-sirolimus-for-the-treatment-of-chronic-hepatitis-c
#18
Grace Elizabeth Dolman, Paul Selby, William T Gelson
The era of direct acting antivirals has revolutionised the management of chronic hepatitis C infection and improved patient outcomes. The optimal management of patients who require liver transplantation remains a matter of ongoing discussion. Treatment in the post-transplantation setting may be complicated by significant drug-drug interactions between antiviral agents and standard immune suppressive treatment regimens. We describe what we believe to be the first reported case of a patient successfully treated for CHC with ombitasvir/paritaprevir/ritonavir plus dasabuvir, while taking sirolimus following liver transplantation...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29880368/safety-of-direct-acting-antiviral-therapy-regarding-renal-function-in-post-liver-transplant-patients-infected-with-hepatitis-c-virus-and-a-100-12-week-sustained-virologic-response-a-single-center-study
#19
G Peschel, L Moleda, L Baier, M Selgrad, S Schmid, M N Scherer, M Müller, K Weigand
BACKGROUND: Patients after liver transplantation (LT) with hepatitis C virus (HCV) infection often suffer from renal or hepatic impairment. Treating patients after LT with direct-acting antivirals (DAA) might result in decreasing renal function due to interaction of DAA and immunosuppressive therapy. In this single-center study we analyzed clinical parameters of 18 HCV-infected patients treated with DAA therapy after LT. METHODS: The primary end points were change of renal function (glomerular filtration rate) and sustained virologic response 12 weeks after therapy (SVR12)...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29878644/very-late-relapse-of-hepatitis-c-virus-infection-immediately-after-liver-transplantation
#20
Domitille Erard-Poinsot, Caroline Scholtès, Claire Billoud, Fabien Zoulim, Jérôme Dumortier
Late relapse of hepatitis C virus infection is very rare in the era of modern direct acting antiviral therapy. We report here the first case of a late relapse, after direct acting antiviral therapy, occurring immediately after liver transplantation (LT), with 93 weeks of sustained virological response before LT. HCV-RNA in serum and in liver biopsy was negative the day of LT and relapse was diagnosed eleven days after LT. HCV NS5A sequencing was performed on samples before and after LT with 99% of homology demonstrating a true late relapse rather than a reinfection...
June 7, 2018: American Journal of Transplantation
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