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https://www.readbyqxmd.com/read/29149817/high-density-lipoprotein-hdl-dysfunction-and-future-of-hdl
#1
Sibel Ertek
Although high density lipoprotein cholesterol (HDL-C) levels are inversely proportional to cardiovascular risk in many studies, recent pharmacological interventional studies with HDL-C raising strategies did not show a benefit in terms of vascular events. The HDL particle is heterogenous with anti-atherogenic functions and non-vascular effects. Many factors affect HDL components and may either cause compositional changes, post-translational modifications of proteins, or alter lipids and other cargo molecules; generally these factors cause more than one of these changes, resulting in functional differences...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29149664/copper-phospholipid-interaction-at-cell-membrane-model-hydrophobic-surfaces
#2
Marina Mlakar, Vlado Cuculić, Sanja Frka, Blaženka Gašparović
Detailed investigation of Cu (II) binding with natural lipid phosphatidylglycerol (PG) in aqueous solution was carried out by voltammetric measurements at the mercury drop electrode, complemented by monolayer studies in a Langmuir trough and electrophoretic measurements, all used as models for hydrophobic cell membranes. Penetration of copper ions into the PG layer was facilitated by the formation of hydrophilic Cu-Phenanthroline (Phen) complex in the subphase, followed by the mixed ligand Cu-Phen-PG complex formation at the hydrophobic interface...
November 11, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29149234/calcium-dependent-hydrolysis-of-supported-planar-lipids-was-triggered-by-honey-bee-venom-phospholipase-a2-with-the-right-orientation-at-the-interface
#3
Siqi Kai, Xu Li, Bolin Li, Xiaofeng Han, Xiaolin Lu
Hydrolysis of planar phospholipids catalyzed by honey bee venom phospholipase A2 (bvPLA2) was studied. Experiments demonstrated that Ca(2+) ions mediated between the lipids and bvPLA2, induced reorientation of bvPLA2, and activated hydrolysis. One of the hydrolysis products, fatty acids, was desorbed, and the other one, lysophospholipids, self-organized at the interface.
November 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29148780/a-spectroscopic-study-of-the-interaction-of-carboxyl-modified-gold-nanoparticles-with-liposomes-of-different-chain-lengths-and-controlled-drug-release-by-layer-by-layer-technology
#4
Nishu Kanwa, Soumya Kanti Dey, Chandan Adhikari, Anjan Chakraborty
In this manuscript, we investigate the interactions of carboxyl modified gold nanoparticles (AuC) with zwitterionic phospholipid liposomes of different chain lengths using a well-known membrane probe PRODAN by steady state and time resolved spectroscopy. We used three zwitterionic lipids, namely, dipalmitoylphosphatidylcholine (DPPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC); which are widely different in their phase transition temperatures to form liposome-AuC assemblies...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29148584/metabolic-effects-of-p-p-dde-on-atlantic-salmon-hepatocytes
#5
Pål A Olsvik, Liv Søfteland
Decades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p'-DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects. This study aimed at examining the impact of p,p'-DDE on Atlantic salmon. Primary hepatocytes were exposed to four concentrations of p,p'-DDE (0.1, 1, 10, 100 μm) for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcription and metabolomics profiling (100 μm)...
November 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29148364/salibacterium-lacus-sp-nov-a-halophilic-non-spore-forming-bacterium-isolated-from-sediment-of-a-saline-lake
#6
Yue-Qiang Wang, Xiao-Ming Liu, Jia Tang, Gui-Qin Yang, Zhen Yu
A novel halophilic bacterium, strain GSS13(T), capable of growing at salinities of 8-28 % (w/v) NaCl (optimally at 24 %, w/v) was isolated from Yuncheng Saline Lake in China. GSS13(T) was Gram-stain-positive, strictly aerobic, rod-shaped, motile and a non-spore-former. Growth occurred at pH 5.5-8.5 (optimum pH 7.0) and at 10-45 °C (optimum 30 °C). On the basis of the results of 16S rRNA gene sequences phylogenetic analyses, GSS13(T) represents a member of the genus Salibacterium and is closely related to Salibacterium halotolerans S7(T), Salibacterium qingdaonense CM1(T) and Salibacterium halochares MSS4(T), with 16S rRNA gene sequence similarities of 98...
November 17, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29148359/albirhodobacter-confluentis-sp-nov-isolated-from-an-estuary
#7
Hye Su Jung, Jaegeun Lee, Jong Woo Hyeon, Seogang Hyun, Che Ok Jeon
A Gram-stain-negative and strictly aerobic, moderately halophilic bacterium, designated strain S1-47(T), was isolated from estuary sediment in South Korea. Cells were non-motile rods showing oxidase- and catalase-positive activities. Growth was observed at 10-30 °C (optimum, 25 °C), at pH 5.0-8.0 (optimum, pH 6.0-7.0) and in the presence of 0-6.0 % (w/v) NaCl (optimum, 2.0 %). Strain S1-47(T) contained summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c), summed feature 8 (comprising C18 : 1ω7c and/or C18 : 1ω6c) and C16 : 0 as major cellular fatty acids and ubiquinone-10 as the sole isoprenoid quinone...
November 17, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29148063/studies-on-the-curcumin-phospholipid-complex-solidified-with-soluplus-%C3%A2
#8
Jianan Wang, Lulu Wang, Lan Zhang, Dandan He, Jianming Ju, Weiguang Li
OBJECTIVES: With the purpose of developing a curcumin phospholipid complex (CPC) formulation with high performance, the CPC was prepared and solidified with Soluplus(®) in this study. METHODS: Soluplus(®) was used as a carrier to solidify CPC. The structures of the CPC and curcumin phospholipid complex - Soluplus(®) solidified powder (CSP) - were also characterized by differential scanning electron microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray diffractometer, and flowability, in-vitro dissolution and oral bioavailability were also investigated...
November 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29147983/dynamics-of-microbial-biomass-and-community-composition-after-short-term-water-status-change-in-chinese-paddy-soils
#9
Hongkai Liao, Stephen James Chapman, Yaying Li, Huaiying Yao
Paddy soil experiences repeated anaerobic and aerobic changes during rice growth, the dramatic dynamics of soil water status accompanied by changes in redox condition and O2 availability. However, the effect of rapid water status change on soil microbial biomass and community composition is not well explored. Here, we present a comprehensive study focusing on the short-term water status change in 13 Chinese paddy soils. In order to gain a reliable way to determine soil microbial biomass carbon (MBC) in flooded or water-saturated soils, we also evaluated two different procedures (nitrogen bubbled and 100 °C water bath) to remove chloroform in extracts during the fumigation process...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29147969/effect-of-dietary-phospholipid-levels-on-growth-lipid-metabolism-and-antioxidative-status-of-juvenile-hybrid-snakehead-channa-argus%C3%A3-channa-maculata
#10
Shi-Mei Lin, Fa-Jian Li, Bundit Yuangsoi, Sompong Doolgindachbaporn
The study was conducted to evaluate the effect of dietary phospholipids (PLs) on growth, lipid metabolism, and antioxidative status of hybrid snakehead (Channa argus × Channa maculata). Five isonitrogenous and isolipidic diets with graded levels of PLs (8.5, 19.3, 30.7, 41.5, and 50.8 g kg(-1)) were fed to triplicate groups of juveniles (initial body weight 12.6 ± 0.23 g) for 8 weeks. Results showed that dietary PL supplementation significantly improved growth of juveniles. The final body weight (FBW) and specific growth rate (SGR) significantly increased with dietary PLs increasing from 8...
November 16, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29147686/lipoprotein-a-associated-molecules-are-prominent-components-in-plasma-and-valve-leaflets-in-calcific-aortic-valve-stenosis
#11
Michael Torzewski, Amir Ravandi, Calvin Yeang, Andrea Edel, Rahul Bhindi, Stefan Kath, Laura Twardowski, Jens Schmid, Xiaohong Yang, Ulrich F W Franke, Joseph L Witztum, Sotirios Tsimikas
The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets were categorized pathologically from Both ATX-apoB and ATX-apo(a) were measureable in plasma. Lp(a), autotaxin, OxPL and MDA epitopes progressively increased in immunostaining (p<0.001 for all). Six species of OxPL and LysoPA were identified following extraction from valve leaflets...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29146531/specific-oxygenation-of-plasma-membrane-phospholipids-by-pseudomonas-aeruginosa-lipoxygenase-induces-structural-and-functional-alterations-in-mammalian-cells
#12
Maceler Aldrovandi, Swathi Banthiya, Sven Meckelmann, You Zhou, Dagmar Heydeck, Valerie B O'Donnell, Hartmut Kuhn
Pseudomonas aeruginosa is a gram-negative pathogen, which causes life-threatening infections in immunocompromized patients. These bacteria express a secreted lipoxygenase (PA-LOX), which oxygenates free arachidonic acid to 15S-hydro(pero)xyeicosatetraenoic acid. It binds phospholipids at its active site and physically interacts with lipid vesicles. When incubated with red blood cells membrane lipids are oxidized and hemolysis is induced but the structures of the oxygenated membrane lipids have not been determined...
November 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29146344/lipid-profiles-in-different-parts-of-two-species-of-scallops-chlamys-farreri-and-patinopecten-yessoensis
#13
Xiao-Pei Hu, Qing-Da An, Da-Yong Zhou, Ting Lu, Fa-Wen Yin, Liang Song, Qi Zhao, Jiang-Hua Zhang, Lei Qin, Bei-Wei Zhu, Fereidoon Shahidi
Different classes of lipids and phospholipids (PL) as well as fatty acid (FA) compositions, and glycerophospholipid (GP) molecular species in edible parts (adductor muscles) and by-products (gonads and mantles) of scallops Patinopecten yessoensis and Chlamys farreri were characterized. The lipids contained high levels of polyunsaturated FA (PUFA) (20.44-58.81% of total FAs) and PL (54.99-78.26% of total lipids). Among PL, phosphatidylcholine (41.39-51.86 mol%) was dominant. More than 230 GP species belonging to glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine, lysoglycerophosphoethanolamine and lysoglycerophosphoinositol were characterized...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146248/phosphatidylcholine-absence-affects-the-secretion-of-lipodepsipeptide-phytoxins-in-pseudomonas-syringae-pv-syringae-van-hall-cfcc-1336
#14
Fang Cao, Min Xiong, Shunyi Li, Huawan Cai, Yufang Sun, Sheng Yang, Xin Liu, Rong Zhu, Xuejing Yu, Xingguo Wang
Pseudomonas syringae pv. syringae van Hall CFCC 1336 (Pss 1336) is the causal agent of bacterial disease of stone fruit trees, and also able to elicit hypersensitive response (HR) in non-host tobacco. It is known that this pathogen uses PCS-pathway to synthesize phosphatidylcholine (PC), and mutation of the pcs gene abolishes bacterial PC synthesis. Previous study also found that the 1336 pcs(-) mutant lacking PC in its membrane phospholipids was unable to secrete HrpZ harpin and elicit HR in non-host plants...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29146138/development-of-kidney-transplant-fibrosis-is-inversely-associated-with-plasma-marine-fatty-acid-level
#15
Ivar A Eide, Christina Dörje, My Svensson, Trond Jenssen, Clara Hammarstrøm, Helge Scott, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, Anders Hartmann, Anders Åsberg, Anna V Reisæter, Finn P Reinholt
OBJECTIVE(S): We assessed associations between plasma levels of polyunsaturated fatty acids (PUFAs) and degree of inflammation and interstitial fibrosis in transplanted kidneys. DESIGN: The design of the study was single center cohort study. SUBJECTS: A study population of 156 patients who received a kidney transplant at Oslo University Hospital during 2010. MAIN OUTCOME MEASURE: Kidney transplant biopsies were obtained at 2 months and 1 year after transplantation...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29145892/association-between-plasma-phospholipid-saturated-fatty-acids-and-metabolic-markers-of-lipid-hepatic-inflammation-and-glycaemic-pathways-in-eight-european-countries-a-cross-sectional-analysis-in-the-epic-interact-study
#16
Ju-Sheng Zheng, Stephen J Sharp, Fumiaki Imamura, Albert Koulman, Matthias B Schulze, Zheng Ye, Jules Griffin, Marcela Guevara, José María Huerta, Janine Kröger, Ivonne Sluijs, Antonio Agudo, Aurelio Barricarte, Heiner Boeing, Sandra Colorado-Yohar, Courtney Dow, Miren Dorronsoro, Pia T Dinesen, Guy Fagherazzi, Paul W Franks, Edith J M Feskens, Tilman Kühn, Verena Andrea Katzke, Timothy J Key, Kay-Tee Khaw, Maria Santucci de Magistris, Francesca Romana Mancini, Elena Molina-Portillo, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Jose Ramón Quirós, Olov Rolandsson, Fulvio Ricceri, Annemieke M W Spijkerman, Nadia Slimani, Giovanna Tagliabue, Anne Tjonneland, Rosario Tumino, Yvonne T van der Schouw, Claudia Langenberg, Elio Riboli, Nita G Forouhi, Nicholas J Wareham
BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. METHODS: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries...
November 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29145001/in-vitro-and-in-vivo-evaluation-of-10-hydroxycamptothecin-loaded-poly-n-butyl-cyanoacrylate-nanoparticles-prepared-by-miniemulsion-polymerization
#17
Xin Jin, Sajid Asghar, Xieting Zhu, Zhipeng Chen, Cihui Tian, Lining Yin, Qineng Ping, Yanyu Xiao
In this paper, 10-hydroxycamptothecin (HCPT)-loaded poly (n-butyl cyanoacrylate) nanoparticles (HCPT-PBCA-NPs) co-modified with polysorbate 80, soybean phospholipids, and polyethylene glycol (100) monostearate were successfully prepared via miniemulsion polymerization, and were characterized for particle size, morphology, zeta potential, encapsulation efficiency (EE) and drug loading capacity (DL). The chemical structure of HCPT-PBCA-NPs and the state of HCPT in the PBCA-NPs were investigated by DSC, FTIR and (1)H NMR...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29144410/evaluation-of-different-single-walled-carbon-nanotube-surface-coatings-for-single-particle-tracking-applications-in-biological-environments
#18
Zhenghong Gao, Noémie Danné, Antoine Guillaume Godin, Brahim Lounis, Laurent Cognet
Fluorescence imaging of biological systems down to the single-molecule level has generated many advances in cellular biology. For applications within intact tissue, single-walled carbon nanotubes (SWCNTs) are emerging as distinctive single-molecule nanoprobes, due to their near-infrared photoluminescence properties. For this, SWCNT surfaces must be coated using adequate molecular moieties. Yet, the choice of the suspension agent is critical since it influences both the chemical and emission properties of the SWCNTs within their environment...
November 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29143729/thalassotalea-coralli-sp-nov-isolated-from-the-torch-coral-euphyllia-glabrescens
#19
Der-Shyan Sheu, Shih-Yi Sheu, Pei-Bei Xie, Sen-Lin Tang, Wen-Ming Chen
Strain Eup a-8(T), isolated from a torch coral Euphyllia glabrescens, was characterized using a polyphasic taxonomy approach. Cells of strain Eup a-8(T) were Gram-staining-negative, aerobic, motile by means of a single polar flagellum, poly-β-hydroxybutyrate-containing, rod-shaped and formed white colonies. Optimal growth occurred at 25-30 °C, pH 7-8, and in the presence of 2 % NaCl. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain Eup a-8(T) belonged to the genus Thalassotalea and showed the highest levels of sequence similarity with respect to Thalassotalea ganghwensis JC2041(T) (97...
November 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29143357/influence-of-phosphatidylserine-and-phosphatidylethanolamine-on-farnesol-tolerance-in-candida-albicans
#20
Sahar Hasim, Elyse N Vaughn, Dallas Donohoe, Donna M Gordon, Susan Pfiffner, Todd B Reynolds
Candida albicans is the most common human fungal pathogen. The ability to undergo the morphological transition from yeast to hyphal growth is critical for its pathogenesis. Farnesol, a precursor in the isoprenoid/sterol pathway, is a quorum-sensing molecule produced by C. albicans that inhibits hyphal growth in this polymorphic fungus. Interestingly, C. albicans can tolerate farnesol concentrations that are toxic to other fungi. We hypothesized that changes in phospholipid composition are one of the factors contributing to farnesol tolerance in C...
November 16, 2017: Yeast
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