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https://www.readbyqxmd.com/read/27905606/a-qm-mm-study-of-the-reaction-mechanism-of-human-%C3%AE-ketoacyl-reductase
#1
Fabiola E Medina, Rui P P Neves, Maria J Ramos, Pedro A Fernandes
Human fatty acid synthase (hFAS) is a multifunctional enzyme involved in a wide diversity of biological functions. For instance, it is a precursor of phospholipids and other complex processes such as the de novo synthesis of long chain fatty acid. Human FAS is also a component of biological membranes and it is implicated in the overexpression of several types of cancers. In this work, we describe the catalytic mechanism of β-ketoreductase (KR), which is a catalytic domain of the hFAS enzyme that catalyzes the reduction of β-ketoacyl to β-hydroxyacyl with the concomitant oxidation of the NADPH cofactor...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905555/the-complex-nature-of-calcium-cation-interactions-with-phospholipid-bilayers
#2
Adéla Melcrová, Sarka Pokorna, Saranya Pullanchery, Miriam Kohagen, Piotr Jurkiewicz, Martin Hof, Pavel Jungwirth, Paul S Cremer, Lukasz Cwiklik
Understanding interactions of calcium with lipid membranes at the molecular level is of great importance in light of their involvement in calcium signaling, association of proteins with cellular membranes, and membrane fusion. We quantify these interactions in detail by employing a combination of spectroscopic methods with atomistic molecular dynamics simulations. Namely, time-resolved fluorescent spectroscopy of lipid vesicles and vibrational sum frequency spectroscopy of lipid monolayers are used to characterize local binding sites of calcium in zwitterionic and anionic model lipid assemblies, while dynamic light scattering and zeta potential measurements are employed for macroscopic characterization of lipid vesicles in calcium-containing environments...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905210/erythrocyte-fatty-acid-composition-does-not-influence-levels-of-free-bioavailable-and-total-25-hydroxy-vitamin-d
#3
Martin Carlsson, Ingela Nilsson, Lars Brudin, Siv-Ping Von, Pär Wanby
In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 ± 2.0 years) total 25(OH)D was measured by LC-MS/MS (n = 78), free 25(OH)D with ELISA (n = 64 of 78), and bioavailable 25(OH)D was calculated...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27905068/inhibition-of-mevalonate-pathway-and-synthesis-of-the-storage-lipids-in-human-liver-derived-and-non-liver-cell-lines-by-lippia-alba-essential-oils
#4
Sandra Montero-Villegas, Mónica Polo, Marianela Galle, Boris Rodenak-Kladniew, María Castro, Ana Ves-Losada, Rosana Crespo, Margarita García de Bravo
The essential oils (EOs) of Lippia alba, an herb extensively used as a folk medicine in Latin America, are today promoted as an effective means of eliminating problems caused by hyperlipemia. We hypothesized that L.alba EOs inhibited cholesterol and triacylglycerols synthesis and decreased the intracellular depots of those lipids (lipid droplets), mechanisms involving the induction of a hypolipidemic response. Our aim was, therefore, to evaluate the hypolipogenic capability of the EOs of four L. alba chemotypes on liver-derived (HepG2) and non-liver (A549) human cell lines and to identify the potential biochemical targets of those chemotypes, particularly within the mevalonate pathway (MP)...
November 30, 2016: Lipids
https://www.readbyqxmd.com/read/27903801/inhibition-of-an-aquatic-rhabdovirus-demonstrates-promise-of-a-broad-spectrum-antiviral-for-use-in-aquaculture
#5
Bethany F Balmer, Rachel L Powers, Ting-Hu Zhang, Jihye Lee, Frederic Vigant, Benhur Lee, Michael E Jung, Maureen K Purcell, Kevin Snekvik, Hector C Aguilar
: Many enveloped viruses cause devastating disease in aquaculture, resulting in significant economic impact. LJ001 is a broad-spectrum antiviral compound that inhibits enveloped viral infections by specifically targeting phospholipids in the lipid bilayer via production of singlet oxygen ((1)O2). This stabilizes positive curvature and decreases membrane fluidity, which inhibits viral-cell membrane fusion during viral entry. Based on previous mammalian studies and the requirement of light for activation of LJ001, we hypothesized that LJ001 may be useful as a preventative and/or therapeutic agent for enveloped viral infections in aquaculture...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27903654/carbon-and-acyl-chain-flux-during-stress-induced-triglyceride-accumulation-by-stable-isotopic-labeling-of-the-polar-microalga-coccomyxa-subellipsoidea-c169
#6
James W Allen, Concetta C DiRusso, Paul N Black
Deriving biofuels and other lipoid products from algae is a promising future technology directly addressing global issues of atmospheric CO2 balance. To better understand the metabolism of triglyceride synthesis in algae, we examined their metabolic origins in the model species, Coccomyxa subellipsoidea C169, using stable isotopic labeling. Labeling patterns arising from (13)C-U-glucose, (13)CO2, or D2O supplementation were analyzed by GC-MS and/or LC-MS over time courses during nitrogen (N) starvation to address the roles of catabolic carbon (C) recycling, acyl chain redistribution, and de novo fatty acid (FA) synthesis during the expansion of the lipid bodies...
November 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27902352/cohnella-lubricantis-sp-nov-isolated-from-a-coolant-lubricant-solution
#7
Peter Kämpfer, Stefanie P Glaeser, Hans-Jürgen Busse
A Gram-staining-positive, aerobic, non-endospore forming organism, isolated from a coolant lubricant solution was studied for its taxonomic position. On the basis of 16S rRNA gene sequence similarity comparisons, strain KSS-154-50T was grouped into the genus Cohnella, most closely related to Cohnella formosensis ALFALFA-35T (97.3 %), Cohnella rhizosphaerae CSE-5610T (97.1 %) and Cohnella nanjingensis D-45T (97.0%). The 16S rRNA gene sequence similarity to other Cohnella species was < 97.0 %. The fatty acid profile from whole cell hydrolysates was very similar to those reported for other Cohnella species supported the allocation to the genus Cohnella...
November 9, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902335/defluviitalea-raffinosedens-sp-nov-a-novel-thermophilic-anaerobic-saccharolytic-bacterium-isolated-from-an-anaerobic-batch-digester-treating-animal-manure-and-rice-straw
#8
Shichun Ma, Yan Huang, Cong Wang, Hui Fan, Lirong Dai, Zheng Zhou, Xing Liu, Yu Deng
A thermophilic, anaerobic, fermentative bacterium, strain A6T, was obtained from an anaerobic batch digester treating animal manure and rice straw. The strain was Gram-positive, slightly curved rods with a size of 0.6-1 μm × 2.5-8.2 μm, non-motile, and produced terminal spores. The temperature, pH, and NaCl concentration ranges for growth were 40°C-60°C, 6.5-8.0, and 0-15.0 g/L, with optimum growth noted at 50°C-55°C, pH 7.5, and in the absence of NaCl, respectively. Yeast extract was required for growth...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902327/microbaculum-marinum-gen-nov-sp-nov-isolated-from-deep-seawater
#9
Yue Su, Shuaibo Han, Ruijun Wang, Xiaoyun Yu, Geyi Fu, Can Chen, Chongya Zhang, Yu Li, Cong Sun, Min Wu
A Gram-stain-negative, aerobic, rod-shaped and non-motile bacterium, designated HSF11T, was isolated from deep seawater of the South China Sea. Growth was observed at 20-40 °C (optimum, 35 °C), pH 5.0-8.5 (optimum, 7.0-7.5) and with 0-7 % NaCl (optimum, 2 %). Bacteriochlorophyll a and poly-β-hydroxybutyrate (PHB) granules were not detected. Nitrate could be reduced to nitrite. The major fatty acids (≥5 %) of strain HSF11T were C19:0 cyclo ω8c, C18:0 and C16:0. The isoprenoid quinone was Q-10. The total lipids were diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), two unknown phospholipids (PL1, PL2), one unknown aminolipid (AL1) and three unknown lipids (L1, L3, L4)...
November 8, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902326/caenimicrobium-hargitense-gen-nov-sp-nov-a-new-member-of-the-family-alcaligenaceae-betaproteobacteria-isolated-from-activated-sludge
#10
Tamas Felfoldi, Peter Schumann, Anikó Mentes, Zsuzsa Kéki, István Máthé, Erika Tóth
A new betaproteobacterium, CGII-59m2T, was isolated from an activated sludge bioreactor which treated landfill leachate. The 16S rRNA gene sequence analysis revealed that strain CGII-59m2T belonged to the family Alcaligenaceae and shared the highest pairwise similarity values with Parapusillimonas granuli LMG 24012T (97.7%), various Bordetella species (97.3-97.0%) and Candidimonas nitroreducens LMG 24812T (97.0%). Strain CGII-59m2T was rod-shaped, non-motile, oxidase and catalase positive. The predominant fatty acids were C16:1ω7c, C16:0, cycloC17:0 and C18:1ω7c, the major respiratory quinone was Q-8, and the main polar lipids were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol and an unknown phospholipid...
November 17, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902318/streptomyces-capparidis-sp-nov-a-novel-endophytic-actinobacterium-isolated-from-fruits-of-capparis-spinosa-l
#11
Hong-Fei Wang, Qiu-Li Li, Min Xiao, Yong-Guang Zhang, Xing-Kui Zhou, Manik Prabhu Narsing Rao, Yan-Qing Duan, Wen-Jun Li
A novel endophytic actinobactrium strain, designated EGI 6500195T, was isolated from Capparis spinosa. Growth occurred at 10-45 °C (optimum 30 °C), pH 6-8 (optimum pH 7) and in the presence of 0-1% NaCl (w/v). The strain EGI 6500195T shared the highest 16S rRNA gene sequence similarity (97.74 %) with Streptomyces vitaminophilus DSM 41686T and less than 97% sequence similarities with other members of the genus Streptomyces. The diagnostic amino acid in the peptidoglycan was LL-diaminopimelic acid. Whole-cell hydrolysates contained glucose, ribose,fructose and mannose...
October 18, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902316/echinicola-strongylocentroti-sp-nov-isolated-from-a-sea-urchin-strongylocentrotus-intermedius
#12
You-Jung Jung, Sung Hyun Yang, Kae Kyung Kwon, Seung Seob Bae
A yellowish-orange-pigmented marine bacterium, designated MEBiC08714T was isolated from a sea urchin Strongylocentrotus intermedius collected at the west edge of the East Sea of Korea. Phylogenetic analysis based on the 16S rRNA gene sequences indicated that strain MEBiC08714T was affiliated with the genus Echinicola and showed that the strain was most closely related to Echinicola vietnamensis KCTC 12713T (96.9%) and followed by 'E. shivajiensis' JCM 17847T (96.3%), E. jeungdonensis KCTC 23122T (96.1%), and E...
November 24, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902315/nocardioides-cavernae-sp-nov-a-novel-actinobacterium-isolated-from-a-karst-cave
#13
Ming-Xian Han, Bao-Zhu Fang, Ye Tian, Wan-Qin Zhang, Jian-Yu Jiao, Lan Liu, Zi-Tong Zhang, Min Xiao, Da-Qiao Wei, Wen-Jun Li
A novel actinobacterial strain, designated YIM A1136T, was isolated from a soil sample collected from a karst cave in Xingyi county, Guizhou province, south-western China. Taxonomic position of the strain was investigated using a polyphasic approach. Cells of the strain were aerobic, Gram-staining-positive and rod-shaped. Colonies of strain were circular, convex, opaque and yellowish white in colour. On the basis of 16S rRNA gene sequence analysis, strain YIM A1136T is most closely related to the type strains of Nocardioides ganghwensis JC2055T (98...
November 21, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902310/paenibacillus-silvae-sp-nov-isolated-from-tropical-rainforest-soil
#14
Huiqin Huang, Fute Zhang, Min Liu, Ying Cui, Qianguang Sun, Jun Zhu, Xiaoxiao Zou, Shixiang Bao
Two Gram-stain-positive, facultatively aerobic, endospore-forming and rod-shaped bacteria, designated DB13031T and DB13311, were isolated from soil of Jiaxi Nature Reserve in Hainan, China. 16S rRNA gene analysis of the strains DB13031T and DB13311 showed that they were within the Paenibacillus cluster, with the highest similarities of Paenibacillus cucumis AP-115T (98.4 % and 98.3 %, respectively), Paenibacillus barcinonensis BP-23T (98.3 % and 98.2 %, respectively) and Paenibacillus oceanisediminis L10T (97...
October 25, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902309/flexivirga-oryzae-sp-nov-isolated-from-soil-of-a-rice-paddy-and-emended-description-of-the-genus-flexivirga-anzai-et-al-2012
#15
Jong Woo Hyeon, Hye Rim Kim, Hyo Jung Lee, Sang Eun Jeong, Sang Ho Choi, Che Ok Jeon
A Gram-staining-positive, strictly aerobic bacterium, designated R1T, was isolated from a rice paddy in South Korea. Cells were non-motile cocci showing oxidase-negative and catalase-positive activities. Growth of strain R1T was observed at 10-37 °C (optimum, 30 C) and pH 5.0-9.0 (optimum, pH 7.0). Strain R1T contained iso-C16 : 0, summed feature 9 (comprising iso-C17 : 1 ω9c/C16 : 0 10-methyl) , anteiso-C17 : 0, iso-C17 : 0 and anteiso-C17 : 1 ω9c as the major fatty acids and MK-8 (H4) and MK-8 (H6) as the isoprenoid quinones...
November 11, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902308/altererythrobacter-soli-sp-nov-isolated-from-desert-sand-sample
#16
Qi Zhao, Hui-Ru Li, Qing-Qing Han, Ao-Lei He, Cong-Yuan Nie, Suo-Min Wang, Jin-Lin Zhang
An alkaliphilic strain designed MN-1T was isolated from a desert sand sample collected from Tengger desert, north-western China. To delineate its taxonomic position, the Gram-staining-negative, rod-shaped, strictly aerobic bacterium, strain MN-1T was subjected to polyphasic taxonomic studies. Growth was observed at temperatures from 4 to 37 ºC (optimum 30 ºC and 32 ºC), at salinities from 0 to 2 % (optimum 1%) and at pH from 6.5 to 12.0 (optimum 7.0-9.0). Phylogenetic analysis based on 16S rRNA gene sequencing showed that the strain MN-1T was a member of the genus Altererythrobacter and distinguished from the recognized species of this genus...
November 9, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902300/kibdelosporangium-metalli-sp-nov-isolated-from-rare-earth-mine-of-bayan-obo-in-china
#17
Yan-Ru Cao, Wen-Qing Yang, Ya Dao, Bin Hu, Zhong-Kan He, Lian-Ming Liang
A Gram-positive, sporangium-like globular bodies forming, oxidase-negative, catalase-positive isolate from the rare earth mine of Bayan Obo in China, designated strain KC 266T, was subjected to a comprehensive taxonomic study. Comparative 16S rRNA gene sequence analysis revealed that strain KC 266T represented a novel lineage within the genus Kibdelosporangium and showed highest 16S rRNA gene similarities to K. philippinense (98.5%), K. aridum subsp. largum (98.2%), K. aridum subsp. aridum (98.2%) and K. phytohabitans (98...
October 17, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902296/allostreptomyces-psammosilenae-gen-nov-sp-nov-an-endophytic-actinobacterium-isolated-from-the-roots-of-psammosilene-tunicoides-and-emended-description-of-the-family-streptomycetaceae-waksman-and-henrici-1943-al-emend-rainey-et-al-1997-emend-kim-et-al-2003-emend
#18
Mei-Juan Huang, Manik Prabhu Narsing Rao, Nimaichand Salam, Min Xiao, Hai-Quan Huang, Wen-Jun Li
A Gram-staining positive actinobacterium, designated strain YIM DR4008T was isolated from the root sample of Psammosilene tunicoides collected from Lijiang, Yunnan, China. Strain YIM DR4008T could grow at temperature ranging from 10 to 50 °C (optimum at 28-30 °C), pH 5.0-11.0 (optimum pH 7.0) and in the presence of up to 4 % (w/v) NaCl. Sequence analysis of the 16S ribosomal RNA gene revealed that strain YIM DR4008T shared highest similarity (95.0 %) with Streptomyces griseoplanus NBRC 12779T and < 95 % similarity with other known members of the genera Streptomyces, Kitasatospora and Streptacidiphilus...
October 27, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902295/kribbella-deserti-sp-nov-isolated-from-rhizosphere-soil-of-ammopiptanthus-mongolicus
#19
Ji-Quan Sun, Lian Xu, Yan Guo, Wei-Le Li, Zhong-Qiu Shao, Yuan-Liang Yang, Xiao-Lei Wu
A Gram-staining-positive, aerobic bacterial strain, designated SL15-1T was isolated from desert soil which sampled from the rhizosphere of Ammopiptanthus mongolicus, Hangjin Banner, Inner Mongolia, northern China. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain SL15-1T was clustered with Kribbella strains, sharing the highest similarity of 16S rRNA gene (96.97%) to Kribbella sandramycini DSM 15626T. Strain SL15-1T contained diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylcholine (PC), an unknown phospholipid (PL), an unknown lipid (L) and two unknown aminophospholipids (APL) as the major polar lipids...
November 25, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902289/polymorphobacter-glacialis-sp-nov-isolated-from-ice-core%C3%AF-china
#20
Tingting Xing, Yongqin Liu, Baiqing Xu, Ninglian Wang, Keshao Liu, Liang Shen, Zhengquan Gu, Bixi Guo, Hongcan Liu, Yuguang Zhou
A Gram-stain-negative, non-spore-forming, rod-shaped bacterium, B555-2T was isolated from an ice core drilled from Muztagh Glacier on the Tibetan Plateau, China. According to phylogenetic analysis with 16S rRNA ribosomal gene sequences, the novel strain was most closely related to Polymorphobacter fuscus D40PT and Polymorphobacter multimanifer 262-7T with 98.4% and 96.9% similarity, respectively. It grew optimally at pH 7 and 15 °C with 0.6% NaCl (m/v). Carotenoid was detected from the cells. Major polar lipids were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, sphingoglycolipid, phophatidylmonomethy lethanolamine, phophatidulcholine, unidentified phospholipid and 5 unidentified lipids...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
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