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risk evaluation in coronary syndrome

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https://www.readbyqxmd.com/read/28927187/impact-of-co-morbid-burden-on-mortality-in-patients-with-coronary-heart-disease-heart-failure-and-cerebrovascular-accident-a-systematic-review-and-meta-analysis
#1
Muhammad Rashid, Chun Shing Kwok, Chris P Gale, Patrick Doherty, Ivan Olier, Matthew Sperrin, Evangelos Kontopantelis, George Peat, Mamas A Mamas
Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson Co-morbidity Index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods and results: We searched MEDLINE and EMBASE to identify studies that evaluated the impact of CCI on mortality in patients with cardiovascular disease. A random-effects meta-analysis was undertaken to evaluate the impact of CCI on mortality in patients with coronary heart disease (CHD), heart failure (HF), and cerebrovascular accident (CVA)...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28927185/the-contribution-of-the-composite-of-clinical-process-indicators-as-a-measure-of-hospital-performance-in-the-management-of-acute-coronary-syndromes-insights-from-the-concordance-registry
#2
Bernadette Aliprandi-Costa, James Sockler, Leonard Kritharides, Lucy Morgan, Lan-Chi Snell, Janice Gullick, David Brieger, Isuru Ranasinghe
Aims: Acute coronary syndrome (ACS) is a costly condition for health service provision yet variation in the delivery of care between hospitals persists. A composite measure of adherence with evidence-based clinical-process indicators (CPIs) could better inform hospital performance reporting and clinical outcomes in the management of ACS. Methods: Data on 7444 ACS patients from 39 Australian hospitals were used to derive a hospital-specific composite quality score by calculating mean adherence to 14 evidence-based CPIs...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28923712/il-15-polymorphisms-are-associated-with-subclinical-atherosclerosis-and-cardiovascular-risk-factors-the-genetics-of-atherosclerosis-disease-gea-mexican-study
#3
Javier Angeles-Martínez, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Eyerahi Bravo-Flores, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Interleukin IL-15 (IL-15) has been implicated in the development of coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-15 gene polymorphisms as susceptibility markers for development of subclinical atherosclerosis (SA) and cardiovascular risk factors in Mexican population. Four IL-15 gene polymorphisms (rs4956403, rs3806798, rs1057972 and rs10833) were analyzed in a group of 397 individuals with SA and 1120 controls. Under different inheritance models adjusted by traditional risk factors, the rs10833T allele was associated with increased risk of developing SA [OR=1...
September 15, 2017: Cytokine
https://www.readbyqxmd.com/read/28923628/role-of-coronary-angiography-in-pre-liver-transplantation-cardiac-evaluation-experience-from-an-asian-transplant-institution
#4
N Q Pang, W C A Kow, J H Law, L T T Pan, B L K Lim, C C R Wong, K Y S Chang, I S Ganpathi, K Madhavan
BACKGROUND: Liver transplant (LT) patients with significant coronary artery disease (CAD) have poorer outcomes. Pre-LT coronary angiography (CA) is associated with significant complications in cirrhotic patients. METHODS: This study aimed to identify predictors of abnormal CA in pre-LT cardiac assessment and to develop a predictive model to reduce unnecessary CA. From January 2006 to June 2013, 122 patients underwent CA based on the current institutional protocol...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28920703/prognostic-usefulness-of-an-age-adapted-equation-for-renal-function-assessment-in-older-patients-with-acute-coronary-syndrome
#5
Lucía Rioboo Lestón, Emad Abu-Assi, Sergio Raposeiras-Roubin, Rafael Cobas-Paz, Berenice Caneiro-Queija, Jose Manuel Rodríguez-Rodríguez, Andres Íñiguez-Romo
BACKGROUND: Renal dysfunction negatively impacts survival in acute coronary syndrome patients. The Berlin Initiative Study creatinine-based (BIScrea) equation has recently been proposed for renal function assessment in older persons. However, up to now it is unknown if the superiority of the new BIScrea equation, with respect to the most recommended chronic kidney disease epidemiology collaboration creatinine-based (CKD-EPIcrea) formula, would translate into better risk prediction of adverse events in older patients with acute coronary syndrome...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28916600/white-blood-cell-count-and-major-adverse-cardiovascular-events-after-percutaneous-coronary-intervention-in-the-contemporary-era-insights-from-the-paris-study-patterns-of-non-adherence-to-anti-platelet-regimens-in-stented-patients-registry
#6
Binita Shah, Usman Baber, Stuart J Pocock, Mitchell W Krucoff, Cono Ariti, C Michael Gibson, Philippe Gabriel Steg, Giora Weisz, Bernhard Witzenbichler, Timothy D Henry, Annapoorna S Kini, Thomas Stuckey, David J Cohen, Ioannis Iakovou, George Dangas, Melissa B Aquino, Samantha Sartori, Alaide Chieffo, David J Moliterno, Antonio Colombo, Roxana Mehran
BACKGROUND: Elevated white blood cell (WBC) count is associated with increased major adverse cardiovascular events (MACE) in the setting of acute coronary syndrome. The aim of this study was to evaluate whether similar associations persist in an all-comers population of patients undergoing percutaneous coronary intervention in the contemporary era. METHODS AND RESULTS: In the multicenter, prospective, observational PARIS study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients who underwent percutaneous coronary intervention in the United States and Europe between July 1, 2009, and December 2, 2010, were evaluated...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28902642/the-association-between-apelin-gene-polymorphism-and-coronary-artery-disease-in-young-patients-with-acute-obstructive-coronary-syndrome
#7
Ramazan Güven, Kamil Can Akyol, Nermin Bayar, Mustafa Keşaplı, Muhammed İkbal Şaşmaz, Asım Arı, Şakir Arslan
OBJECTIVE: The purpose of this study was to evaluate the association between V103V, 6140AG, TGA-Stop-TAA Stop, and 6016CA polymorphisms of the apelin (APLN) gene detected for the first time among young patients with acute coronary syndrome (ACS) and coronary artery disease (CAD). METHODS: This was a prospective cross-sectional study. The study population was divided into 2 groups. The first group included 132 patients who were found to have critical lesions in their coronary arteries, while the control group consisted of 41 patients who were found to have normal coronary arteries or non-critical atherosclerotic lesions...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28893450/emergency-medicine-evaluation-and-management-of-the-end-stage-renal-disease-patient
#8
REVIEW
Brit Long, Alex Koyfman, Courtney M Lee
BACKGROUND: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. These patients may experience significant complications associated with loss of renal function and dialysis. OBJECTIVE: This review evaluates complications of ESRD including cardiopulmonary, neurologic, infectious disease, vascular, and access site complications, as well as medication use in this population...
September 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28892959/prevalence-of-conventional-risk-factors-and-evaluation-of-baseline-indices-among-young-and-elderly-patients-with-coronary-artery-disease
#9
Arsalan Majeed Adam, Aiman Rehan, Nageen Waseem, Unzela Iqbal, Hira Saleem, Muhammad Armughan Ali, Ali Tariq Shaikh, Ansab Godil
INTRODUCTION: Coronary Artery Disease (CAD) is a leading cause of morbidity and mortality worldwide, manifesting in a variety of clinical spectrums such as an asymptomatic disease or acute coronary syndrome. It has become highly prevalent in Southeast Asia, including Pakistan. There has been little work done on the prevalence of traditional risk factors in different age groups and genders and there is a dire need to gauge the importance of baseline indices in CAD patients. AIM: To determine the prevalence of conventional risk factors and evaluate the variations in lipid profiles, electrolyte levels and haematological indices among patients with CAD in different age groups and gender...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28889793/hemorheological-dysfunction-in-cardiac-syndrome-x
#10
Emine Kilic-Toprak, Olga Yaylali, Yalin Tolga Yaylali, Yasin Ozdemir, Dogangun Yuksel, Hande Senol, Tarık Sengoz, Melek Bor-Kucukatay
BACKGROUND: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity - PV) in patients with CSX. METHODS: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56...
September 11, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28885323/pik3cg-single-nucleotide-polymorphisms-are-associated-with-poor-responsiveness-to-clopidogrel-and-increased-risk-of-ischemia-in-patients-with-coronary-heart-disease
#11
Ke-Cheng Li, Shu-Hong Yu, Bao-Zhong Zhuge
BACKGROUND: This study explores the associations between PIK3CG single nucleotide polymorphisms (SNPs, rs1129293 and rs17398575) and patient responsiveness to clopidogrel to evaluate the risks of ischemia in patients with coronary heart disease (CHD). METHODS: The study consisted of 513 CHD patients who received clopidogrel as part of antiplatelet therapy, after percutaneous coronary intervention. According to the patient responsiveness to clopidogrel, the subjects were assigned to either clopidogrel-resistant (CR) or clopidogrel-sensitive (CS) groups...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28875970/-evaluation-of-selected-vascular-active-factors-in-patients-after-myocardial-infarction-subjected-to-cardiac-rehabilitation
#12
Joanna Kapusta, Anna Mejer-Barczewska, Edward Kowalczyk, Robert Irzmański, Jan Kowalski
Atherosclerosis is an inflammatory process that develops in the coronary arteries. Clinically active agents such as proinflammatory interleukins, TNF-α, tissue inhibitors of metalloproteinases (including TIMP-1), and vascular endothelial growth factor (VEGF), are important factors in the development of acute coronary syndromes. AIM: The aim of the study was to evaluate the effect of cardiac rehabilitation (stage II) on the concentration of selected vascular active factors (IL- 1, IL-6, TIMP-1, VEGF)...
August 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28875506/medications-recommended-for-secondary-prevention-after-first-acute-coronary-syndrome-effectiveness-of-treatment-combinations-in-real-life-setting
#13
Julien Bezin, Olaf H Klungel, Régis Lassalle, Caroline Dureau-Pournin, Nicholas Moore, Antoine Pariente
Long-term effectiveness of Evidence-Based Cardiovascular Medications (EBCMs) indicated after Acute Coronary Syndrome (ACS) needs to be assessed considering the combination effects for these drugs recommended in association. Using a nationwide database, we conducted a cohort study to evaluate the effectiveness of all possible incomplete EBCMs-based combinations as compared to that associating the four recommended EBCMs over up to five years of follow-up. Among the 31,668 patients included, 22.9% had ACS recurrence or died during follow-up...
September 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28868074/update-on-pharmacological-treatment-of-acute-coronary-syndrome-without-persistent-st-segment-elevation-myocardial-infarction-in-the-elderly
#14
REVIEW
Coşkun Usta, Aslı Bedel
The increase in cardiovascular disease prevalence with ageing has been attributed to several age-related changes such as changes in the vascular wall elasticity, the coagulation and haemostatic system and endothelial dysfunction, among other causes. There is a 50% increased mortality risk per 10-year increase in age starting at 65 years old. Here, we aimed to discuss pharmacological treatment in acute coronary syndrome (ACS) without persistent ST segment elevation myocardial infarction in the elderly. The main aim of ACS treatment in elderly people is at preventing ischemia, myocardial damage and complications...
July 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28868073/antithrombotic-treatment-tailoring-and-risk-score-evaluation-in-elderly-patients-diagnosed-with-an-acute-coronary-syndrome
#15
REVIEW
Alexandru Nicolae Mischie, Catalina Liliana Andrei, Crina Sinescu, Gani Bajraktari, Eugen Ivan, Georgios Nikolaos Chatziathanasiou, Michele Schiariti
Age is an important prognostic factor in the outcome of acute coronary syndromes (ACS). A substantial percentage of patients who experience ACS is more than 75 years old, and they represent the fastest-growing segment of the population treated in this setting. These patients present different patterns of responses to pharmacotherapy, namely, a higher ischemic and bleeding risk than do patients under 75 years of age. Our aim was to identify whether the currently available ACS ischemic and bleeding risk scores, which has been validated for the general population, may also apply to the elderly population...
July 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28867682/surgical-outcomes-of-isolated-coronary-artery-bypass-grafting-for-acute-coronary-syndrome%C3%A3-based-on-the-japan-adult-cardiovascular-surgery-database
#16
Shunsuke Kawamoto, Hiroaki Miyata, Noboru Motomura, Kazuo Tanemoto, Shinichi Takamoto, Yoshikatsu Saiki
BACKGROUND: The present study aimed to clarify the current use and outcomes of coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS) based on the Japan Adult Cardiovascular Surgery Database (JACVSD) in stratified risk categories, and also to provide guidance on selection of optimal surgical strategies for ACS.Methods and Results:From January 2008 through December 2012, 7,867 isolated CABG procedures for ACS were identifiedfrom the JACVSD. Patients were stratified into 3 subgroups (<2%, 2-9...
September 1, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28867023/machine-learning-for-prediction-of-30-day-mortality-after-st-elevation-myocardial-infraction-an-acute-coronary-syndrome-israeli-survey-data-mining-study
#17
Roni Shouval, Amir Hadanny, Nir Shlomo, Zaza Iakobishvili, Ron Unger, Doron Zahger, Ronny Alcalai, Shaul Atar, Shmuel Gottlieb, Shlomi Matetzky, Ilan Goldenberg, Roy Beigel
BACKGROUND: Risk scores for prediction of mortality 30-days following a ST-segment elevation myocardial infarction (STEMI) have been developed using a conventional statistical approach. OBJECTIVE: To evaluate an array of machine learning (ML) algorithms for prediction of mortality at 30-days in STEMI patients and to compare these to the conventional validated risk scores. METHODS: This was a retrospective, supervised learning, data mining study...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28862961/sudden-cardiac-death-in-women-with-suspected-ischemic-heart-disease-preserved-ejection-fraction-and-no-obstructive-coronary-artery-disease-a-report-from-the-women-s-ischemia-syndrome-evaluation-study
#18
Puja K Mehta, B Delia Johnson, Tanya S Kenkre, Wafia Eteiba, Barry Sharaf, Carl J Pepine, Steven E Reis, William J Rogers, Sheryl F Kelsey, Diane V Thompson, Vera Bittner, George Sopko, Leslee J Shaw, C Noel Bairey Merz
BACKGROUND: Sudden cardiac death (SCD) is often the first presentation of ischemic heart disease; however, there is limited information on SCD among women with and without obstructive coronary artery disease (CAD). We evaluated SCD incidence in the WISE (Women's Ischemia Syndrome Evaluation) study. METHODS AND RESULTS: Overall, 904 women with suspected ischemic heart disease with preserved ejection fraction and core laboratory coronary angiography were followed for outcomes...
August 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28855770/dual-antiplatelet-therapy-and-the-severity-risk-of-lower-intestinal-bleeding
#19
Neal Carlin, Fady Asslo, Raymund Sison, Hamid Shaaban, Walid Baddoura, Faiza Manji, Joseph Depasquale
BACKGROUND: Dual antiplatelet (Plt) therapy with aspirin and clopidogrel is recommended for up to 1 year following acute coronary syndrome. Many of these cardiac patients are also on anithrombotic therapy like warfarin. Lower gastrointestinal bleeding (LGIB) is the main adverse event of this treatment. AIMS: The main purpose of this study was to analyze the relationship of dual anti-Plt therapy and the risk of LGIB. METHODS: Patients' electronic charts were reviewed to include a total of 19 variables, which included age, sex, ethnicity, daily use aspirin of any dose, daily use of clopidogrel, use of nonsteroidal anti-inflammatory drugs (NSAIDs) at least twice in the last week prior to admission and the daily use of anticoagulants (warfarin, heparin), and were obtained from history and physical examination reports, lab transcripts and procedural reports...
July 2017: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/28854264/oral-glucose-tolerance-test-predicts-increased-carotid-plaque-burden-in-patients-with-acute-coronary-syndrome
#20
Thorarinn A Bjarnason, Steinar O Hafthorsson, Linda B Kristinsdottir, Erna S Oskarsdottir, Thor Aspelund, Sigurdur Sigurdsson, Vilmundur Gudnason, Karl Andersen
BACKGROUND: Type 2 diabetes and prediabetes are established risk factors for atherosclerosis. The aim of this study was to evaluate the atherosclerotic plaque burden in the carotid arteries of patients with acute coronary syndrome according to their glycemic status. METHODS: Patients with acute coronary syndrome and no previous history of type 2 diabetes were consecutively included in the study. Glucose metabolism was evaluated with fasting glucose in plasma, HbA1c and a standard two-hour oral glucose tolerance test...
2017: PloS One
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