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https://www.readbyqxmd.com/read/29779197/cardiac-versus-non-cardiac-related-mortality-following-percutaneous-coronary-intervention-in-patients-with-insulin-treated-type-2-diabetes-mellitus-a-meta-analysis
#1
Qiang Wang, Hao Liu, Jiawang Ding
INTRODUCTION: Cardiovascular mortality is a major concern for patients with type 2 diabetes mellitus (T2DM). Insulin therapy significantly contributes to a high rate of death in these patients. We have performed a meta-analysis comparing cardiac and non-cardiac-related mortality following percutaneous coronary intervention (PCI) in a sample of patients with insulin-treated type 2 diabetes mellitus (ITDM). METHODS: Studies were included in the meta-analysis if: (1) they were trials or cohort studies involving patients with T2DM post-PCI; (2) the outcomes in ITDM were separately reported; and (3) they reported cardiac death and non-cardiac death among their clinical endpoints...
May 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29779196/retrospective-analysis-of-an-insulin-to-liraglutide-switch-in-patients-with-type-2-diabetes-mellitus
#2
Eveline Bruinstroop, Laura Meyer, Catherine B Brouwer, Diana E van Rooijen, P Sytze van Dam
INTRODUCTION: Insulin and the GLP-1 receptor agonist liraglutide are both effective in reaching glycemic targets. The efficacy of an insulin-to-liraglutide switch in an obese population with concurrent use of sulfonylurea and metformin is unknown. We assessed the efficacy and determinants of success of an insulin-to-liraglutide switch in these patients. METHODS: In a retrospective study we analyzed all patients that underwent an insulin-to-liraglutide switch during routine medical care (January 2009-February 2015)...
May 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29779195/efficacy-and-safety-of-alirocumab-in-individuals-with-diabetes-mellitus-pooled-analyses-from-five-placebo-controlled-phase-3-studies
#3
Henry N Ginsberg, Michel Farnier, Jennifer G Robinson, Christopher P Cannon, Naveed Sattar, Marie T Baccara-Dinet, Alexia Letierce, Maja Bujas-Bobanovic, Michael J Louie, Helen M Colhoun
INTRODUCTION: Diabetes mellitus (DM) carries an elevated risk for cardiovascular disease. Here, we assessed alirocumab efficacy and safety in people with/without DM from five placebo-controlled phase 3 studies. METHODS: Data from up to 78 weeks were analyzed in individuals on maximally tolerated background statin. In three studies, alirocumab 75 mg every 2 weeks (Q2W) was increased to 150 mg Q2W at week 12 if week 8 low-density lipoprotein cholesterol (LDL-C) was ≥ 70 mg/dL; two studies used alirocumab 150 mg Q2W throughout...
May 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29779142/arousal-index-as-a-marker-of-carotid-artery-atherosclerosis-in-patients-with-obstructive-sleep-apnea-syndrome
#4
Mayumi Suzuki, Ken Shimamoto, Haruki Sekiguchi, Takamitsu Harada, Natsumi Satoya, Yuji Inoue, Kazuhiro Yamaguchi, Masatoshi Kawana
PURPOSE: It was shown in a previous cohort study that men with internal carotid artery (ICA) plaque, defined as focal wall thickness of ≥ 1.5 mm, had a threefold higher risk of stroke than those without plaque. We examined the relationship between arousal indices and sleep stages in patients with obstructive sleep apnea syndrome (OSAS) and carotid atherosclerosis. METHODS: Carotid atherosclerosis severity was evaluated using the maximal carotid wall intima-media thickness of the ICA (ICA-maxIMT) and plaque in 83 patients with OSAS...
May 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29779026/uromodulin-mrna-from-urinary-extracellular-vesicles-correlate-to-kidney-function-decline-in-type-2-diabetes-mellitus
#5
Cindy M Yamamoto, Taku Murakami, Melanie L Oakes, Masato Mitsuhashi, Colleen Kelly, Robert R Henry, Kumar Sharma
BACKGROUND: Extracellular vesicles (EVs) enclose mRNA derived from their cell of origin and are considered a source of potential biomarkers. We examined urinary EV mRNA from individuals with diabetic kidney disease (DKD), chronic kidney disease, type 2 diabetes (T2DM), and obese and healthy controls to determine if such biomarkers had the potential to classify kidney disease and predict patients at higher risk of renal function decline. METHODS: A total of 242 participants enrolled in this study...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778909/n-acetylcysteine-protects-against-diabetic-nephropathy-through-control-of-oxidative-and-nitrosative-stress-by-recovery-of-nitric-oxide-in-rats
#6
Guilherme B Nogueira, Giovana R Punaro, Clemerson S Oliveira, Fabiane R Maciel, Thamires O Fernandes, Deyse Y Lima, Adelson M Rodrigues, Margaret G Mouro, Sergio R R Araujo, Elisa M S Higa
The diabetes mellitus (DM) induces several changes, with substantial increase of reactive oxygen species (ROS). The ROS cause damage to systemic and renal microvasculature, which could be one of the mechanisms involved in the development of diabetic nephropathy (DN). The ROS modulate other substances like the nitric oxide (NO), a vasodilator with important role in the renal function. N-acetylcysteine (NAC) is an antioxidant that acts replenishing intracellular cysteine levels, which is essential for glutathione formation...
May 17, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29778859/diagnosis-of-nonischemic-stage-b-heart-failure-in-type-2-diabetes-mellitus-optimal-parameters-for-prediction-of-heart-failure
#7
Ying Wang, Hong Yang, Quan Huynh, Mark Nolan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to identify whether impaired global longitudinal strain (GLS), diastolic dysfunction (DD), or left atrial enlargement (LAE) should be added to stage B heart failure (SBHF) criteria in asymptomatic patients with type 2 diabetes mellitus. BACKGROUND: SBHF is a precursor to clinical heart failure (HF), and its recognition justifies initiation of cardioprotective therapy. However, original definitions of SBHF were based on LV hypertrophy and impaired ejection fraction...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778853/natural-history-of-diabetic-coronary-atherosclerosis-by-quantitative-measurement-of-serial-coronary-computed-tomographic-angiography-results-of-the-paradigm-study-progression-of-atherosclerotic-plaque-determined-by-computed-tomographic-angiography-imaging
#8
Ung Kim, Jonathon A Leipsic, Stephanie L Sellers, Michael Shao, Philipp Blanke, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min, Hyuk-Jae Chang
OBJECTIVES: This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM). BACKGROUND: The natural history of coronary PP in patients with DM is not well established. METHODS: A total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and analyzed from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778668/thinking-about-brain-insulin-resistance
#9
REVIEW
Reem M Al Haj Ahmad, Hayder A Al-Domi
INTRODUCTION: Dementia and type 2 diabetes mellitus (T2DM) are two of the epidemics of our time; in which insulin resistance (IR) is playing the central role. Epidemiological studies found that different types of dementia development may be promoted by the presence of T2DM. OBJECTIVES: We aimed in this review to highlight the role of insulin and the IR in the brain as a pathophysiological factor of dementia development and also to expand our understanding of T2DM as a mediator of IR in the brain and to review the possible mechanisms of action that may explain the association...
May 6, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29778664/gestational-diabetes-mellitus-modulates-cholesterol-homeostasis-in-human-fetoplacental-endothelium
#10
Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck
Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may affect placental vascular function. Cholesterol homeostasis is crucial for maintaining fetoplacental endothelial function. We aimed to investigate whether and how GDM affects cholesterol metabolism in human fetoplacental endothelial cells (HPEC). HPEC were isolated from fetal term placental arterial vessels of GDM or control subjects. Cellular reactive oxygen species (ROS) were detected by H2 DCFDA fluorescent dye. Oxysterols were quantified by gas chromatography-mass spectrometry analysis...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29778663/glp-1-receptor-agonists-and-reduction-of-cardiometabolic-risk-potential-underlying-mechanisms
#11
REVIEW
Manfredi Rizzo, Dragana Nikolic, Angelo Maria Patti, Carlo Mannina, Giuseppe Montalto, Brooke S McAdams, Ali A Rizvi, Francesco Cosentino
Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM - incretin-based therapies (IBTs), including glucagon-like peptide 1 (GLP-1) receptor agonists, have become popular and more widely used in recent years. The available scientific data from clinical studies and clinical practice highlights their beyond glucose-lowering effects, which is achieved without any increase in hypoglycaemia. The former effects include reduction in body weight, lipids, blood pressure, inflammatory markers, oxidative stress, endothelial dysfunction, and subclinical atherosclerosis, thus reducing and potentially preventing CV events...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29778548/risk-factors-of-the-peptic-ulcer-bleeding-in-aging-uremia-patients-under-regular-hemodialysis
#12
Xi-Hsuan Lin, Chung-Chi Lin, Yuan-Jen Wang, Jiing-Chyuan Luo, Shih-Hao Young, Ping-Hsien Chen, Ming-Chih Hou, Fa-Yauh Lee
BACKGROUND: Previous studies have shown that uremia patients under hemodialysis (HD) have a significantly higher occurrence of peptic ulcer bleeding (PUB) than healthy controls and that elderly patients remain at high risk of peptic ulcer disease (PUD) and PUB. Here we aimed to identify the risk factors for PUB in aging (≥65-years-old) uremic patients under regular HD. METHODS: Using data from the National Health Insurance Research Database of Taiwan, we compared 18,252 aging regular HD patients and 17,883 age-, gender-, and medication-matched patients without kidney disease (control group)...
May 16, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29778128/the-relationship-between-glycaemic-control-and-non-alcoholic-fatty-liver-disease-in-nigerian-type-2-diabetic-patients
#13
Babalola Ishmael Afolabi, Bolanle Olubunmi Ibitoye, Rosemary Temidayo Ikem, Adeleye Dorcas Omisore, Bukunmi Michael Idowu, David Olubukunmi Soyoye
BACKGROUND: Metabolic risk factors associated with non-alcoholic fatty liver disease (NAFLD) include Type 2 diabetes mellitus (T2DM), obesity and dyslipidaemia. Prevention or management of these risk factors with glycaemic control, weight reduction and low serum lipid levels respectively have been reported to reduce the risk of NAFLD or slow its progression. Since ultrasound (USS) is a safe and reliable method of identifying fatty changes in the liver, this study was done to determine the relationship between glycaemic control and ultrasound diagnosed NAFLD in T2DM...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778021/the-homing-of-human-umbilical-cord-derived-mesenchymal-stem-cells-and-the-subsequent-modulation-of-macrophage-polarization-in-type-2-diabetic-mice
#14
Yaqi Yin, Haojie Hao, Yu Cheng, Jieqing Gao, Jiejie Liu, Zongyan Xie, Qi Zhang, Li Zang, Weidong Han, Yiming Mu
Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are associated with increased M2 macrophages, but no systemic evaluation of M2 macrophages has been performed in T2DM individuals...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29777874/asymmetric-dimethylarginine-contributes-to-retinal-neovascularization-of-diabetic-retinopathy-through-ephrinb2-pathway
#15
Mei-Rong Du, Li Yan, Nian-Sheng Li, Yu-Jie Wang, Ting Zhou, Jun-Lin Jiang
Diabetic retinopathy (DR) is a leading cause of vision loss with retinal neovascularization. This study aims to investigate whether Asymmetric dimethylarginine (ADMA) impacts the pathogenesis of DR via focusing on promoting retinal neovascularization and its underlying molecular mechanisms. Diabetic rats were induced by a single intraperitoneal injection of streptozotocin (STZ) for 20 weeks. ADMA levels in aqueous and the influence of hypoxia on ADMA and angiogenesis in RF/6A cells were examined. The effects and underlying molecular mechanisms of ADMA on neovascularization of RF/6A cells were further evaluated by administration of ADMA, DDAH siRNA or ephrinB2 siRNA...
May 16, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29777841/acute-ischemic-pancreatitis-secondary-to-aortic-dissection
#16
Rong Wang, Jun-Ming Zhu, Rui-Dong Qi, Yong-Min Liu, Jun Zheng, Nan Zhang, Li-Zhong Sun
OBJECTIVE: Acute ischemic pancreatitis secondary to aortic dissection is very rare with an unclarified mechanism. We retrospectively reviewed six such cases in our center and present their outcomes herein. MATERIAL AND METHODS: Between February 2009 and April 2017, six patients (male=2, female=4; mean age, 58 ± 8, range 47-70) years) with acute aortic dissection associated with pancreatitis were admitted to our center. There were three type A and three type B dissections...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777831/microcystis-bloom-containing-microcystin-lr-induces-type-2-diabetes-mellitus
#17
Qiong Zhang, Wendi Qin, Liuyan Yang, Jing An, Xuxiang Zhang, Hao Hong, Lizhi Xu, Yaping Wang
Epidemiological data from Lake Taihu showed significantly higher incidences of type 2 diabetes mellitus (T2DM) than in other areas of China. This may be related to the occurrence of a Microcystis bloom in Lake Taihu in the summer and autumn every year. The objective of this study is to investigate whether the contaminated water from the Microcystis bloom and the derivative pollutant microcystin-LR (MC-LR) can explain the higher incidences of T2DM. Healthy male mice were fed with water from different regions of Lake Taihu, and were either acutely or chronically exposed to MC-LR through oral administration or intraperitoneal injection...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29777621/serum-high-density-lipoprotein-cholesterol-is-a-protective-predictor-of-executive-function-in-older-patients-with-diabetes-mellitus
#18
Yue Sun, Jenny Lee, Ronald C Ma, Timothy Kwok
INTRODUCTION: Older people with diabetes mellitus (DM) are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with DM were elucidated. METHODS: This was a secondary analysis of a vitamin B12 intervention trial in older people with DM. 271 non-demented subjects were followed up at nine months interval for 27 months. We explored the association between baseline clinical features with changes in cognitive measures (clinical dementia rating scale, neuropsychological test battery including executive function z scores, psychomotor speed z scores and memory z scores)...
May 19, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29777569/improving-metabolic-stability-with-deuterium-the-discovery-of-hwl-066-a-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#19
Chunxia Liu, Zheng Li, Wei Shi, Huilan Li, Nasi Wang, Yuxuan Dai, Chen Liao, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancing of glucose-stimulated insulin secretion. The FFA1 agonist GW9508 has great potential for the treatment of type 2 diabetes mellitus, but it has been suffering from high plasma clearance probably because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available analog without influence on the unique pharmacological mechanism of GW9508, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid affording compound 4 (HWL-066)...
May 18, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29777549/frailty-risk-in-hospitalized-older-adults-with-and-without-diabetes-mellitus
#20
Deborah A Lekan, Thomas P McCoy
BACKGROUND: Research indicates that diabetes mellitus (DM) may be a risk factor for frailty and individuals with DM are more likely to be frail than individuals without DM, however, there is limited research in hospitalized older adults. OBJECTIVES: To determine the extent of frailty in hospitalized older adults with and without DM using a 16-item Frailty Risk Score (FRS) and assess the role of frailty in predicting 30-day rehospitalization, discharge to an institution, and in-hospital mortality...
May 18, 2018: Journal of Clinical Nursing
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