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https://www.readbyqxmd.com/read/28645623/identification-of-a-coumarin-based-antihistamine-as-an-anti-filoviral-entry-inhibitor
#1
Han Cheng, Adam Schafer, Veronica Soloveva, Dima Gharaibeh, Tara Kenny, Cary Retterer, Rouzbeh Zamani, Sina Bavari, Norton P Peet, Lijun Rong
Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filovirus infection in humans. The recent 2013-2015 West African Ebola epidemic underscores the urgency to develop antiviral therapeutics against these infectious diseases. Our previous study showed that GPCR antagonists, particularly histamine receptor antagonists (antihistamines) inhibit Ebola and Marburg virus entry...
June 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28644755/a-contemporary-examination-of-first-and-second-permanent-molar-emergence
#2
B T Pahel, W F Vann, K Divaris, R G Rozier
The emergence of first permanent molars (FPMs) and second permanent molars (SPMs) is an important developmental milestone influencing caries risk and the timing of sealant placement. Emergence times have been shown to vary by sex and race/ethnicity, while recent reports suggest a positive association with adiposity. Amid the changing demographics of the US population and the rising rates of pediatric overweight/obesity, we sought to examine the association of body mass index (BMI) with FPM/SPM emergence in a representative sample of US children and adolescents...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28643822/-preventive-dentistry-6-prevention-of-caries-in-frail-older-people
#3
C D van der Maarel-Wierink, C de Baat
Many older people have a bad oral health, with (root) caries a prevalent cause. Alarming results of research projects raise the question whether sufficient preventive measures are being taken to prevent the development and progress of (root) caries in frail older people. A review of the recent literature revealed that in frail older people and physically or cognitively impaired adults, daily use of a 5,000 ppm fluoride toothpaste and quarterly application of chlorhexidine or sodium fluoride can decrease by half the risk of root caries...
June 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28643162/dental-caries-a-disease-which-needs-attention
#4
Vijay Prakash Mathur, Jatinder Kaur Dhillon
Dental caries is one of the most prevalent disease (about 50%) in children across the globe. If not treated in time, it can affect not only the mastication function but also the speech, smile and psychosocial environment and the quality of life of the child and the family. The treatment of dental diseases is very expensive in all countries and prevention is very simple and effective. The caries in children below 6 y is called early childhood caries (ECC). It is most commonly caused by milk bottle or mother's feed during night...
June 23, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28642533/book-review-understanding-dental-caries-from-pathogenesis-to-prevention-and-therapy
#5
Devesh Shelat
No abstract text is available yet for this article.
June 23, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28642519/comment-on-the-paper-entitled-arginine-and-caries-prevention-a-systematic-review
#6
(no author information available yet)
'The Colgate-Palmolive Company is extremely proud of the clinical program ... addition of 1.5% arginine to fluoride toothpaste.'
June 23, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28642057/novel-multifunctional-dental-cement-to-prevent-enamel-demineralization-near-orthodontic-brackets
#7
Yansong Ma, Ning Zhang, Michael D Weir, Yuxing Bai, Hockin H K Xu
OBJECTIVES: White spot lesions due to biofilm acid-induced enamel demineralization are prevalent in orthodontic treatments. The aim of this study was to develop a novel bioactive multifunctional cement with protein-repellent, antibacterial and remineralizing capabilities, and investigate the effects on enamel hardness and lesion depth in vitro for the first time. MATERIALS AND METHODS: 2-Methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM), and nanoparticles of amorphous calcium phosphate (NACP) were incorporated into a resin-modified glass ionomer (RMGI)...
June 19, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28637986/the-logic-behind-the-use-of-fissure-sealant-retention-as-a-proxy-outcome-measure-for-dental-caries-prevention
#8
Steffen Mickenautsch
Fissure sealant retention is traditionally considered as a proxy measure for caries prevention. This study investigated the logic behind this proposition, and its validity. A logical framework of the proposition was established. The mechanism of caries development was transferred into a Directed acyclic graph, and this was used to investigate the logical framework. The sensitivity and specificity of full sealant retention in the prediction of dental carious lesion development and the number of false positive/false negative prediction rates were computed...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28634492/effectiveness-of-different-preventive-programs-in-cariogram-parameters-of-young-adults-at-high-caries-risk
#9
Said Karabekiroğlu, Nimet Ünlü
OBJECTIVE: To evaluate the effectiveness of different preventive programs in young adults at high caries risk using Cariogram software. METHODS: Sixty-six young adults with high caries risk were evaluated. Dental caries risk for all subjects was determined according to WHO criteria. Subjects were divided into three different preventive groups (control: OH, fluoride varnish: FV, and chlorhexidine varnish: CV). They were followed for 12 weeks (baseline: T0, 1 week: T1, 4 weeks: T2, and 12 weeks: T3)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28633647/meeting-the-oral-health-needs-of-12-year-olds-in-china-human-resources-for-oral-health
#10
Xiangyu Sun, Eduardo Bernabé, Xuenan Liu, Shuguo Zheng, Jennifer E Gallagher
BACKGROUND: An appropriate level of human resources for oral health [HROH] is required to meet the oral health needs of population, and enable maximum improvement in health outcomes. The aim of this study was to estimate the required HROH to meet the oral health needs of the World Health Organization [WHO] reference group of 12-year-olds in China and consider the implications for education, practice, policy and HROH nationally. METHODS: We estimated the need of HROH to meet the needs of 12-year-olds based on secondary analysis of the epidemiological and questionnaire data from the 3rd Chinese National Oral Health Survey, including caries experience and periodontal factors (calculus), dentally-related behaviour (frequency of toothbrushing and sugar intake), and social factors (parental education)...
June 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28630645/the-use-of-laparoscopy-in-managing-penetrating-thoracoabdominal-injuries-in-africa-83-cases-reviewed
#11
Zach M Koto, Fusi Mosai, Oleh Y Matsevych
BACKGROUND: The use of laparoscopy in managing haemodynamically stable patients with penetrating thoracoabdominal injuries in developed countries is wildly practiced, but in Africa, the use of laparoscopy is still in its infancy stage. We reviewed a single centre experience in using laparoscopy in Africa for management of patients with both isolated diaphragmatic injuries as well as diaphragmatic injuries associated with intra-abdominal injuries requiring intervention. METHODS: A retrospective analysis of prospectively collected data of patients presenting with penetrating thoracoabdominal injuries was done...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28628586/building-a-pediatric-oral-health-training-curriculum-for-community-health-workers
#12
Molly Martin, William Frese, Christie Lumsden, Anna Sandoval
OBJECTIVES: Community health workers (CHWs) are a promising approach to oral health promotion in high-risk populations. This article describes the process of creating a pediatric oral health CHW training curriculum. DESIGN: Existing curricula were identified through outreach efforts to experts in the oral health and CHW fields, as well as PubMed and Google searches. After coding basic information, curricula were mapped to define oral health domains. Then group discussion was employed to determine final curriculum contents...
June 16, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28624838/dental-management-of-pediatric-patients-affected-by-pulmonary-atresia-with-ventricular-septal-defect-a-scoping-review
#13
A Garrocho-Rangel, A-C Echavarría-García, M-A Rosales-Bérber, J Flores-Velázquez, A Pozos-Guillén
BACKGROUND: Congenital Heart Diseases (CHD) involves a wide range of pathological conditions, such as Pulmonary Atresia with Ventricle Septal Defect (PA/VSD). This disorder leads to the systemic circulation of oxygen-poor blood (cyanosis), with associated features and consequences in the oral cavity. MATERIAL AND METHODS: Using scoping review methodology for screening and article selection, the primary objectives of this paper were as follows: first, to pose a research question; second, to identify relevant studies in order to answer the research question; third, to select and retrieve the studies; fourth, to chart the critical data, and finally, to collate, summarize, and report the results from the most important articles on the dental management of children affected with PA/VSD...
June 18, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28621818/healthy-futures-engaging-the-oral-health-community-in-childhood-obesity-prevention-conference-summary-and-recommendations
#14
Raul I Garcia, Dushanka Kleinman, Katrina Holt, Ann Battrell, Paul Casamassimo, Jane Grover, Norman Tinanoff
Childhood obesity is a major public health problem. An association between obesity and dental caries, the most prevalent disease of childhood, has been identified. One explanation for the association is that consumption of sugar-sweetened beverages and frequent snacking on carbohydrate-rich foods are common risk factors for development of both obesity and caries. The Robert Wood Johnson Foundation (RWJF) has been at the forefront of national efforts to promote healthy weight in children. As part of these efforts, RWJF sponsored the Healthy Futures: Engaging the Oral Health Community in Childhood Obesity Prevention National Conference, held on November 3-4, 2016, at Georgetown University in Washington, DC...
June 16, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28621280/utility-of-dermatoglyphic-pattern-in-prediction-of-caries-in-children-of-telangana-region-india
#15
Shaik M Asif, Dara Bg Babu, Shaik Naheeda
INTRODUCTION: Dermatoglyphics is an extremely useful tool as a preliminary investigation method for diagnosing suspected genetic disorders. Caries being a multifactorial disease with the influence of genetic pattern, early identification of caries risk children with dermatoglyphics can help in using effective and efficient caries preventive measures. AIMS AND OBJECTIVES: The study was undertaken to record and know the frequency of occurrence of fingerprint patterns among children with caries and in children without caries...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28620634/dental-caries-and-associated-factors-in-children-aged-2-4-years-old-in-mbeya-city-tanzania
#16
Hery Mwakayoka, Joyce Rose Masalu, Emil Namakuka Kikwilu
STATEMENT OF THE PROBLEM: Dental caries in infants and young children is prevalent worldwide; its magnitude and associated factors vary between communities because of cultural and social economic differences. No such information was available for pre-school children in Mbeya city. PURPOSE: To determine dental caries status and associated factors in 2 to 4-year-old children in Mbeya city. MATERIALS AND METHOD: A cross sectional study was conducted among 525 children aged 2-4 years and their parents/caregivers...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28618424/preventive-and-therapeutic-proximal-sealing-a-3-5-year-randomized-controlled-clinical-trial-follow-up
#17
Cristian P Basili, Claes Göran Emilson, Gonzalo C Corvalan, Maria Paz Moran, Carlos Torres, Mariela D Quiroz, Santiago Sergio Gomez
OBJECTIVE: The aim of this split-mouth, randomized controlled clinical trial was to evaluate the efficacy of proximal sealing for avoiding the development of new caries lesions or arresting incipient caries lesions on the mesial surface of first permanent molars (6m) abutting lesions on the distal surface of second primary molars (05d) in children at high caries risk. METHODS: A total of 61 children 8-10 years old were selected based on the caries status of the proximal sites of 05d and 6m...
June 16, 2017: Caries Research
https://www.readbyqxmd.com/read/28613154/seal-or-varnish-a-randomised-controlled-trial-to-determine-the-relative-cost-and-effectiveness-of-pit-and-fissure-sealant-and-fluoride-varnish-in-preventing-dental-decay
#18
Ivor Gordon Chestnutt, Simon Hutchings, Rebecca Playle, Sarah Morgan-Trimmer, Deborah Fitzsimmons, Nadine Aawar, Lianna Angel, Sharron Derrick, Cheney Drew, Ceri Hoddell, Kerenza Hood, Ioan Humphreys, Nigel Kirby, Tin Man Mandy Lau, Catherine Lisles, Maria Zeta Morgan, Simon Murphy, Jacqueline Nuttall, Kateryna Onishchenko, Ceri Phillips, Timothy Pickles, Charlotte Scoble, Julia Townson, Beverley Withers, Barbara Lesley Chadwick
BACKGROUND: Fissure sealant (FS) and fluoride varnish (FV) have been shown to be effective in preventing dental caries when tested against a no-treatment control. However, the relative clinical effectiveness and cost-effectiveness of these interventions is unknown. OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of FS and FV in preventing dental caries in first permanent molars (FPMs) in 6- and 7-year-olds and to determine their acceptability...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28613022/parental-attitudes-towards-oral-health-and-caries-risk-in-their-children
#19
J H Vermaire, Nja van Exel
OBJECTIVES: The aim of this study was to investigate whether parents can be matched with attitudes towards oral health by means of a short vignette sheet, developed based on the results of an earlier Q-methodological study. Furthermore, this study aims to explore how the attitudes associate with diet and oral hygiene habits and with clinical outcomes in children. METHODS: A total of 170 parents of 6- to 9-year-old children completed a questionnaire including the vignette sheet and clinical scores (oral hygiene, caries) were retrieved from the follow-up measurement of a RCT on caries-preventive measures...
June 14, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28608827/associations-of-community-water-fluoridation-with-caries-prevalence-and-oral-health-inequality-in-children
#20
Han-Na Kim, Jeong-Hee Kim, Se-Yeon Kim, Jin-Bom Kim
This study aimed to confirm the association between the community water fluoridation (CWF) programme and dental caries prevention on permanent teeth, comparing to a control area, neighbouring population without the programme, and verifying whether the programme can reduce the socio-economic inequality related to the oral health of children in Korea. Evaluation surveys were conducted among 6-, 8-, and 11-year-old children living in Okcheon (CWF) and neighbouring Yeongdong (non-CWF, control area) towns in South Korea...
June 13, 2017: International Journal of Environmental Research and Public Health
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